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1. Supplementary Figure S1. FGFR1 protein expression and FGFR1 gene copy-numbers in HPV-positive and HPV-negative head and neck squamous cell carcinoma. from FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Author

Koole, Koos, primary, Brunen, Diede, primary, van Kempen, Pauline M.W., primary, Noorlag, Rob, primary, de Bree, Remco, primary, Lieftink, Cor, primary, van Es, Robert J.J., primary, Bernards, René, primary, and Willems, Stefan M., primary

Published
2023
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2. Supplementary Table S1. Results of FGFR1 protein expression and FGFR1 gene copy-numbers in HPV-positive and HPV-negative head and neck squamous cell carcinoma. from FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Author

Koole, Koos, primary, Brunen, Diede, primary, van Kempen, Pauline M.W., primary, Noorlag, Rob, primary, de Bree, Remco, primary, Lieftink, Cor, primary, van Es, Robert J.J., primary, Bernards, René, primary, and Willems, Stefan M., primary

Published
2023
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6. Bent-housing turbodrills improve hard-formation directional drilling

Author

Koot, Leo, Koole, Koos, and Gaynor, Tom

Subjects
Gas well drilling, Gas industry -- Methods, Drilling and boring machinery -- Design and construction, Business, Petroleum, energy and mining industries
Abstract

Shell U K Exploration & Production uses a newly designed downhole motor to power its directional gas well exploration in hard formations such as the dolomite of the southern North Sea. A steerable turbine-driven motor developed by Neyrfor-Weir Ltd includes bent-housing in conjunction with high-speed flexible coupling, thrust-balancing drums and bearings lubricated by mud. Testing and operation of the equipment are described., Improvements in the design of turbine-powered downhole motors allowed steerable drilling in a hard formation at a high rate of penetration (ROP). Drilling in this dolomite formation with the rotary [...]

Published
1993

8. Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma

Author

Koole, Koos, van Kempen, Pauline M W, Swartz, Justin E, Peeters, Ton, van Diest, Paul J, Koole, Ron, van Es, Robert J. J., and Willems, Stefan M

Subjects
oropharyngeal cancer, Research Support, Non-U.S. Gov't, fibroblast growth factor receptor 3, Journal Article, therapeutic target, oral cancer
Abstract

Fibroblast growth factor receptor 3 (FGFR3) is a member of the fibroblast growth factor receptor tyrosine kinase family. It has been identified as a promising therapeutic target in multiple types of cancer. We have investigated FGFR3 protein expression and FGFR3 gene copy-numbers in a single well-documented cohort of oral and oropharyngeal squamous cell carcinoma. Tissue microarray sets containing 452 formalin-fixed paraffin-embedded tissues were immunohistochemically stained with an anti-FGFR3 antibody and hybridized with a FGFR3 fluorescence in situ hybridization probe. FGFR3 protein expression was correlated with clinicopathological and survival data, which were retrieved from electronic medical records. FGFR3 mRNA data of 522 head and neck squamous cell carcinoma (HNSCC) were retrieved from The Cancer Genome Atlas (TCGA). Fibroblast growth factor receptor 3 (FGFR3) protein was overexpressed in 48% (89/185) of oral and 59% (124/211) of oropharyngeal squamous cell carcinoma. Overexpression of FGFR3 protein was not related to overall survival or disease-free survival in oral (HR[hazard ratio]: 0.94; 95% CI: 0.64-1.39; P = 0.77, HR: 0.94; 95% CI: 0.65-1.36; P = 0.75) and oropharyngeal squamous cell carcinoma (HR: 1.21; 95% CI: 0.81-1.80; P = 0.36, HR: 0.42; 95% CI: 0.79-1.77; P = 0.42). FGFR3 mRNA was upregulated in 3% (18/522) of HNSCC from the TCGA. The FGFR3 gene was gained in 0.6% (1/179) of oral squamous cell carcinoma but no amplification was found in oral and oropharyngeal squamous cell carcinoma. In conclusion, FGFR3 protein is frequently overexpressed in oral and oropharyngeal squamous cell carcinoma. Therefore, it may serve as a potential therapeutic target for FGFR3-directed therapies in oral and oropharyngeal squamous cell carcinoma.

Published
2016

10. FGFR Family Members Protein Expression as Prognostic Markers in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

Author

Pathologie, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), MS KNO, MS Mondziekten/Kaakchirurgie, Circulatory Health, Pathologie Laboratorium diagnostiek, Cancer, Koole, Koos, Clausen, Martijn J A M, van Es, Robert J J, van Kempen, Pauline M W, Melchers, Lieuwe J., Koole, Ron, Langendijk, Johannes A., van Diest, Paul J., Roodenburg, Jan L N, Schuuring, Ed, Willems, Stefan M., Pathologie, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), MS KNO, MS Mondziekten/Kaakchirurgie, Circulatory Health, Pathologie Laboratorium diagnostiek, Cancer, Koole, Koos, Clausen, Martijn J A M, van Es, Robert J J, van Kempen, Pauline M W, Melchers, Lieuwe J., Koole, Ron, Langendijk, Johannes A., van Diest, Paul J., Roodenburg, Jan L N, Schuuring, Ed, and Willems, Stefan M.

Published
2016

11. FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer

Author

Theelen, Willemijn Sme, Mittempergher, Lorenza, Willems, Stefan M, Bosma, Astrid J, Peters, Dennis Dgc, van der Noort, Vincent, Japenga, Eva J, Peeters, Ton, Koole, Koos, Šuštić, Tonći, Blaauwgeers, J L, van Noesel, Carel J, Bernards, René, van den Heuvel, Michel M, Theelen, Willemijn Sme, Mittempergher, Lorenza, Willems, Stefan M, Bosma, Astrid J, Peters, Dennis Dgc, van der Noort, Vincent, Japenga, Eva J, Peeters, Ton, Koole, Koos, Šuštić, Tonći, Blaauwgeers, J L, van Noesel, Carel J, Bernards, René, and van den Heuvel, Michel M

Published
2016

13. FGFR1 is a potential prognostic biomarker and therapeutic target in head and neck squamous cell carcinoma

Author

Pathologie patiënten zorg, UMC Utrecht, Verpleegafdeling Mondz/Kaakchir. D5 Oost, Other research (not in main researchprogram), MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Cancer, CMM Sectie Molecular Cancer Research, Koole, Koos, Brunen, Diede, Van Kempen, Pauline M W, Noorlag, Rob, De Bree, Remco, Lieftink, Cor, Van Es, Robert J J, Bernards, Rene, Willems, Stefan M., Pathologie patiënten zorg, UMC Utrecht, Verpleegafdeling Mondz/Kaakchir. D5 Oost, Other research (not in main researchprogram), MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Cancer, CMM Sectie Molecular Cancer Research, Koole, Koos, Brunen, Diede, Van Kempen, Pauline M W, Noorlag, Rob, De Bree, Remco, Lieftink, Cor, Van Es, Robert J J, Bernards, Rene, and Willems, Stefan M.

Published
2016

14. RET protein is overexpressed in oral squamous cell carcinoma

Author

Pathologie patiënten zorg, UMC Utrecht, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), Cancer, Koole, Koos, Peeters, Ton, van Hengel, Oscar R J, Brinkhuis, Anja, van Es, Robert J J, Willems, Stefan M., Pathologie patiënten zorg, UMC Utrecht, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), Cancer, Koole, Koos, Peeters, Ton, van Hengel, Oscar R J, Brinkhuis, Anja, van Es, Robert J J, and Willems, Stefan M.

Published
2016

15. FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer

Author

Pathologie Pathologen staf, Cancer, Pathologie, CMM Sectie Molecular Cancer Research, Theelen, Willemijn Sme, Mittempergher, Lorenza, Willems, Stefan M, Bosma, Astrid J, Peters, Dennis Dgc, van der Noort, Vincent, Japenga, Eva J, Peeters, Ton, Koole, Koos, Šuštić, Tonći, Blaauwgeers, J L, van Noesel, Carel J, Bernards, René, van den Heuvel, Michel M, Pathologie Pathologen staf, Cancer, Pathologie, CMM Sectie Molecular Cancer Research, Theelen, Willemijn Sme, Mittempergher, Lorenza, Willems, Stefan M, Bosma, Astrid J, Peters, Dennis Dgc, van der Noort, Vincent, Japenga, Eva J, Peeters, Ton, Koole, Koos, Šuštić, Tonći, Blaauwgeers, J L, van Noesel, Carel J, Bernards, René, and van den Heuvel, Michel M

Published
2016

16. Fibroblast Growth Factor Receptor Family Members as Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma: A Systematic Review

Author

Pathologie, MS KNO, Other research (not in main researchprogram), MS Mondziekten/Kaakchirurgie, Circulatory Health, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Ipenburg, Norbertus A., Koole, Koos, Liem, K. Seng, van Kempen, Pauline M W, Koole, Ron, van Diest, Paul J., van Es, Robert J. J., Willems, Stefan M., Pathologie, MS KNO, Other research (not in main researchprogram), MS Mondziekten/Kaakchirurgie, Circulatory Health, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Ipenburg, Norbertus A., Koole, Koos, Liem, K. Seng, van Kempen, Pauline M W, Koole, Ron, van Diest, Paul J., van Es, Robert J. J., and Willems, Stefan M.

Published
2016

17. Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma

Author

Pathologie, MS KNO, Other research (not in main researchprogram), Brain, Cancer, MS Mondziekten/Kaakchirurgie, Circulatory Health, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Koole, Koos, van Kempen, Pauline M W, Swartz, Justin E, Peeters, Ton, van Diest, Paul J, Koole, Ron, van Es, Robert J. J., Willems, Stefan M, Pathologie, MS KNO, Other research (not in main researchprogram), Brain, Cancer, MS Mondziekten/Kaakchirurgie, Circulatory Health, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Koole, Koos, van Kempen, Pauline M W, Swartz, Justin E, Peeters, Ton, van Diest, Paul J, Koole, Ron, van Es, Robert J. J., and Willems, Stefan M

Published
2016

19. FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer

Author

Theelen, Willemijn SME, primary, Mittempergher, Lorenza, additional, Willems, Stefan M, additional, Bosma, Astrid J, additional, Peters, Dennis DGC, additional, van der Noort, Vincent, additional, Japenga, Eva J, additional, Peeters, Ton, additional, Koole, Koos, additional, Šuštić, Tonći, additional, Blaauwgeers, JL, additional, van Noesel, Carel J, additional, Bernards, René, additional, and van den Heuvel, Michel M, additional

Published
2016
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23. FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma

Author

Koole, Koos, van Kempen, Pauline M W, van Bockel, Liselotte W., Smets, Timo, van der Klooster, Zoë, Dutman, Annemiek C., Peeters, Ton, Koole, Ron, van Diest, Paul, van Es, Robert J. J., Willems, Stefan M., Koole, Koos, van Kempen, Pauline M W, van Bockel, Liselotte W., Smets, Timo, van der Klooster, Zoë, Dutman, Annemiek C., Peeters, Ton, Koole, Ron, van Diest, Paul, van Es, Robert J. J., and Willems, Stefan M.

Published
2015

24. Association of varicosities and concomitant deep venous thrombosis in patients with superficial venous thrombosis, a systematic review

Author

Pathologie, HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Baggen, Vivan J M, Chung, Kaman, Koole, Koos, Sarneel, Michelle H J, Rutten, Frans H, Hajer, Gideon R, Pathologie, HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Baggen, Vivan J M, Chung, Kaman, Koole, Koos, Sarneel, Michelle H J, Rutten, Frans H, and Hajer, Gideon R

Published
2015

25. FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma

Author

Pathologie, MS KNO, Other research (not in main researchprogram), MS Radiotherapie, Pathologie Opleiding, Cancer, MS Mondziekten/Kaakchirurgie, Circulatory Health, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Koole, Koos, van Kempen, Pauline M W, van Bockel, Liselotte W., Smets, Timo, van der Klooster, Zoë, Dutman, Annemiek C., Peeters, Ton, Koole, Ron, van Diest, Paul, van Es, Robert J. J., Willems, Stefan M., Pathologie, MS KNO, Other research (not in main researchprogram), MS Radiotherapie, Pathologie Opleiding, Cancer, MS Mondziekten/Kaakchirurgie, Circulatory Health, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Koole, Koos, van Kempen, Pauline M W, van Bockel, Liselotte W., Smets, Timo, van der Klooster, Zoë, Dutman, Annemiek C., Peeters, Ton, Koole, Ron, van Diest, Paul, van Es, Robert J. J., and Willems, Stefan M.

Published
2015

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