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15 results on '"Koo, Se Jun"'

3. Association of hair cortisol concentration with brain‐derived neurotrophic factor gene methylation: The role of sex as a moderator.

Author

Li, Zhenxu, Kong, Wanji, Park, Hye Yoon, Koo, Se Jun, Bang, Minji, Park, Jung Tak, Lee, Eun, and An, Suk Kyoon

Subjects
RESEARCH funding, HYDROCORTISONE, GENE expression, DNA methylation, BRAIN-derived neurotrophic factor, SEX (Biology), HYPOTHALAMIC-pituitary-adrenal axis, HAIR, GENOTYPES
Abstract

Hair cortisol concentration (HCC) reflects the long‐term activity of the hypothalamus‐pituitary‐adrenal (HPA) axis in response to stress. Brain‐derived neurotrophic factor DNA methylation (BDNF DNAM) may affect HCC, and sex and Val66Met may contribute to this association. Thus, the aim of this study was to investigate the associations between HCC and Brain‐derived neurotrophic factor (BDNF) DNAM, and the moderating effects of Val66Met and sex. We recruited 191 healthy young participants (96 women, mean age 23.0 ± 2.6 years) and collected body samples to evaluate HCC, and to determine BDNF DNAM and Val66Met genotypes. We analyzed the effects of BDNF DNAM, sex, and Val66Met on HCC. We also evaluated the associations between BDNF DNAM and HCC in groups separated by sex and genotypes. We found a marked association of BDNF DNAM with HCC across men and women. After dividing the data by sex, a positive correlation of HCC with BDNF DNAM was found only in women. There was no substantial moderation effect of Val66Met genotypes on the association between BDNF DNAM and HCC. Therefore, BDNF DNAM was found to have positive association with HCC only in healthy young women, indicating that sex moderates the association of BDNF DNAM with long‐term HPA axis activity. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Empathy and Theory of Mind in Ultra-High Risk for Psychosis: Relations With Schizotypy and Executive Function

Author

Kong, Wanji, Koo, Se Jun, Seo, Eunchong, Park, Hye Yoon, Lee, Eun, and An, Suk Kyoon

Subjects
Anhedonia, media_common.quotation_subject, Schizotypy, Empathy, Affect (psychology), Executive functions, Social cognition, Psychiatry and Mental health, Self-other boundary, Wisconsin Card Sorting Test, Theory of mind, Magical ideation, Interpersonal Reactivity Index, medicine, Original Article, sense organs, medicine.symptom, Psychology, Biological Psychiatry, Empathic concern, media_common, Clinical psychology
Abstract

Objective While recent studies have found deficits in theory of mind (ToM) skills in individuals at ultra-high risk (UHR) for psychosis, empathic tendencies in these subjects remain unclear. The presence of high schizotypy and compromised executive functions, which are found in UHR individuals, would affect ToM skills and empathic tendencies. We investigated the ToM skills and empathic tendencies of UHR individuals and examined their relationship with schizotypy and executive function.Methods This study included 28 UHR individuals and 28 age- and sex-matched healthy controls. All participants completed a self-reported empathic scale (Interpersonal Reactivity Index) and the Wisconsin Schizotypy Scales. Additionally, the ToM Picture Stories Task and Wisconsin Card Sorting Test were conducted.Results UHR individuals showed a trend toward lower self-reported empathic tendencies; however, there were no differences in ToM skills between the two groups. Of the four subscales of the IRI, only empathic concern showed a significant difference between the two groups. Empathic concern was inversely associated with negative schizotypy.Conclusion Our findings suggest that UHR individuals show relatively preserved cognitive empathy but compromised emotional empathy. Furthermore, in UHR individuals, the empathic concern subscale of the IRI was associated with negative schizotypy, while ToM skills were related to positive schizotypy and executive function.

Published
2021

8. Online_Supplementary_Material – Supplemental material for Reduced activation of the ventromedial prefrontal cortex during self-referential processing in individuals at ultra-high risk for psychosis

Author

Park, Hye Yoon, Kyoungri Park, Eunchong Seo, Koo, Se Jun, Minji Bang, Park, Jin Young, Kang, Jee In, Lee, Eun, Seung-Koo Lee, and An, Suk Kyoon

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, Online_Supplementary_Material for Reduced activation of the ventromedial prefrontal cortex during self-referential processing in individuals at ultra-high risk for psychosis by Hye Yoon Park, Kyoungri Park, Eunchong Seo, Se Jun Koo, Minji Bang, Jin Young Park, Jee In Kang, Eun Lee, Seung-Koo Lee and Suk Kyoon An in Australian & New Zealand Journal of Psychiatry

Published
2020
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15. Association of hair cortisol concentration with brain-derived neurotrophic factor gene methylation: The role of sex as a moderator.

Author

Li Z, Kong W, Park HY, Koo SJ, Bang M, Park JT, Lee E, and An SK

Subjects
Humans, Female, Male, Adult, Young Adult, Sex Factors, Genotype, Brain-Derived Neurotrophic Factor metabolism, Brain-Derived Neurotrophic Factor genetics, Hydrocortisone metabolism, Hair chemistry, Hair metabolism, DNA Methylation
Abstract

Hair cortisol concentration (HCC) reflects the long-term activity of the hypothalamus-pituitary-adrenal (HPA) axis in response to stress. Brain-derived neurotrophic factor DNA methylation (BDNF DNA M ) may affect HCC, and sex and Val66Met may contribute to this association. Thus, the aim of this study was to investigate the associations between HCC and Brain-derived neurotrophic factor (BDNF) DNA M , and the moderating effects of Val66Met and sex. We recruited 191 healthy young participants (96 women, mean age 23.0 ± 2.6 years) and collected body samples to evaluate HCC, and to determine BDNF DNA M and Val66Met genotypes. We analyzed the effects of BDNF DNA M , sex, and Val66Met on HCC. We also evaluated the associations between BDNF DNA M and HCC in groups separated by sex and genotypes. We found a marked association of BDNF DNA M with HCC across men and women. After dividing the data by sex, a positive correlation of HCC with BDNF DNA M was found only in women. There was no substantial moderation effect of Val66Met genotypes on the association between BDNF DNA M and HCC. Therefore, BDNF DNA M was found to have positive association with HCC only in healthy young women, indicating that sex moderates the association of BDNF DNA M with long-term HPA axis activity., (© 2024 The Authors. Stress and Health published by John Wiley & Sons Ltd.)

Published
2024
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