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4. Neuropsychologie in der Kinder- und Jugendpsychiatrie

Author

Konrad, Kerstin, Döpfner, Manfred, Section editor, Fegert, Jörg M., Section editor, Legenbauer, Tanja, Section editor, Resch, Franz, Section editor, Kaess, Michael, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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5. Neurobiologische Forschungsmethoden in der Kinder- und Jugendpsychiatrie und -psychotherapie

Author

Konrad, Kerstin, Reindl, Vanessa, Döpfner, Manfred, Section editor, Fegert, Jörg M., Section editor, Legenbauer, Tanja, Section editor, Resch, Franz, Section editor, Kaess, Michael, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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6. Adverse Childhood Experiences (ACE) – belastende Kindheitserlebnisse

Author

Fegert, Jörg M., Sachser, Cedric, Witt, Andreas, Konrad, Kerstin, Section editor, Resch, Franz, Section editor, Legenbauer, Tanja, Section editor, Kaess, Michael, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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7. Migration und Flucht – Auswirkungen auf Kinder und Jugendliche

Author

Fragner, Laura, Schiffler, Tobias, Plener, Paul L., Konrad, Kerstin, Section editor, Resch, Franz, Section editor, Fegert, Jörg M., Section editor, Legenbauer, Tanja, Section editor, Kaess, Michael, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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8. Mobbing als Risikofaktor im Kindes- und Jugendalter

Author

Kaess, Michael, Jantzer, Vanessa, Konrad, Kerstin, Section editor, Resch, Franz, Section editor, Fegert, Jörg M., Section editor, Legenbauer, Tanja, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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9. Armut als Risikofaktor in Kindheit und Jugendalter

Author

Hähnle, Sarah, Weilemann, Mitja, Fegert, Jörg M., Konrad, Kerstin, Section editor, Resch, Franz, Section editor, Legenbauer, Tanja, Section editor, Kaess, Michael, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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10. Resilienz bei Kindern und Jugendlichen

Author

Witt, Andreas, Konrad, Kerstin, Section editor, Resch, Franz, Section editor, Fegert, Jörg M., Section editor, Legenbauer, Tanja, Section editor, Kaess, Michael, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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12. Tourette- und Tic-Störungen in Kindheit und Jugend

Author

Döpfner, Manfred, Roessner, Veit, Konrad, Kerstin, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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13. Intelligenzminderung im Kindes- und Jugendalter

Author

Sarimski, Klaus, Häßler, Frank, Konrad, Kerstin, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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15. Rechenstörungen im Kindes- und Jugendalter

Author

von Aster, Michael, Kaufmann, Liane, McCaskey, Ursina, Kucian, Karin, Konrad, Kerstin, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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17. Die Rolle der Schule in der kindlichen und jugendlichen Entwicklung

Author

Hanisch, Charlotte, Thomas, Hennemann, Fegert, Jörg M., Section editor, Resch, Franz, Section editor, Konrad, Kerstin, Section editor, Plener, Paul L., Section editor, Döpfner, Manfred, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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18. Transitionsphasen in der Entwicklung von Kindern und Jugendlichen

Author

Fegert, Jörg M., Karow, Anne, Schulze, Ulrike, Resch, Franz, Section editor, Konrad, Kerstin, Section editor, Plener, Paul L., Section editor, Döpfner, Manfred, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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19. Entwicklungspsychopathologie im Kindes- und Jugendalter

Author

Resch, Franz, Fegert, Jörg M., Section editor, Konrad, Kerstin, Section editor, Plener, Paul L., Section editor, Döpfner, Manfred, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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20. Unterstützung für Kinder, Jugendliche und junge Erwachsene in und nach gesellschaftlichen Krisen : Die Rolle der Kinder- und Jugendpsychiatrie und -psychotherapie

Author

Fegert, Jörg M., Erlewein, Katrin, Gossmann, Emily, Resch, Franz, Section editor, Konrad, Kerstin, Section editor, Plener, Paul L., Section editor, Döpfner, Manfred, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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21. Wachstum und neurobiologische Entwicklung im Kindes- und Jugendalter

Author

Thyen, Ute, Konrad, Kerstin, Fegert, Jörg M., Section editor, Resch, Franz, Section editor, Plener, Paul L., Section editor, Döpfner, Manfred, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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22. Kognitive und sozioemotionale Entwicklung

Author

Döpfner, Manfred, Fegert, Jörg M., Section editor, Resch, Franz, Section editor, Konrad, Kerstin, Section editor, Plener, Paul L., Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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23. Bindung im Kindes- und Jugendalter

Author

Ziegenhain, Ute, Fegert, Jörg, Section editor, Resch, Franz, Section editor, Konrad, Kerstin, Section editor, Plener, Paul, Section editor, Döpfner, Manfred, Section editor, Fegert, Jörg M., editor, Resch, Franz, editor, Kaess, Michael, editor, Döpfner, Manfred, editor, Konrad, Kerstin, editor, Legenbauer, Tanja, editor, and Plener, Paul, editor

Published
2024
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26. Emotion processing in maltreated boys and girls: Evidence for latent vulnerability

Author

Diaconu, Bianca, Kohls, Gregor, Rogers, Jack C., Pauli, Ruth, Cornwell, Harriet, Bernhard, Anka, Martinelli, Anne, Ackermann, Katharina, Fann, Nikola, Fernandez-Rivas, Aranzazu, Gonzalez-Torres, Miguel Angel, Gonzalez de Artaza-Lavesa, Maider, Hervas, Amaia, Stadler, Christina, Konrad, Kerstin, Freitag, Christine M., Fairchild, Graeme, Rotshtein, Pia, and De Brito, Stephane A.

Published
2023
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27. Autism spectrum disorder classification based on interpersonal neural synchrony: Can classification be improved by dyadic neural biomarkers using unsupervised graph representation learning?

Author

Gerloff, Christian, Konrad, Kerstin, Kruppa, Jana, Schulte-Rüther, Martin, and Reindl, Vanessa

Subjects
Computer Science - Machine Learning, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Research in machine learning for autism spectrum disorder (ASD) classification bears the promise to improve clinical diagnoses. However, recent studies in clinical imaging have shown the limited generalization of biomarkers across and beyond benchmark datasets. Despite increasing model complexity and sample size in neuroimaging, the classification performance of ASD remains far away from clinical application. This raises the question of how we can overcome these barriers to develop early biomarkers for ASD. One approach might be to rethink how we operationalize the theoretical basis of this disease in machine learning models. Here we introduced unsupervised graph representations that explicitly map the neural mechanisms of a core aspect of ASD, deficits in dyadic social interaction, as assessed by dual brain recordings, termed hyperscanning, and evaluated their predictive performance. The proposed method differs from existing approaches in that it is more suitable to capture social interaction deficits on a neural level and is applicable to young children and infants. First results from functional near-infrared spectroscopy data indicate potential predictive capacities of a task-agnostic, interpretable graph representation. This first effort to leverage interaction-related deficits on neural level to classify ASD may stimulate new approaches and methods to enhance existing models to achieve developmental ASD biomarkers in the future., Comment: Accepted in Medical Image Computing and Computer Assisted Intervention - MICCAI 2022: The 5th International Workshop on Machine Learning in Clinical Neuroimaging

Published
2022

32. Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable

Author

Pauli, Ruth, Brazil, Inti A., Kohls, Gregor, Klein-Flügge, Miriam C., Rogers, Jack C., Dikeos, Dimitris, Dochnal, Roberta, Fairchild, Graeme, Fernández-Rivas, Aranzazu, Herpertz-Dahlmann, Beate, Hervas, Amaia, Konrad, Kerstin, Popma, Arne, Stadler, Christina, Freitag, Christine M., De Brito, Stephane A., and Lockwood, Patricia L.

Published
2023
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33. Towards a youth mental health paradigm: a perspective and roadmap

Author

Uhlhaas, Peter J., Davey, Christopher G., Mehta, Urvakhsh Meherwan, Shah, Jai, Torous, John, Allen, Nicholas B., Avenevoli, Shelli, Bella-Awusah, Tolulope, Chanen, Andrew, Chen, Eric Y. H., Correll, Christoph U., Do, Kim Q., Fisher, Helen L., Frangou, Sophia, Hickie, Ian B., Keshavan, Matcheri S., Konrad, Kerstin, Lee, Francis S., Liu, Cindy H., Luna, Beatriz, McGorry, Patrick D., Meyer-Lindenberg, Andreas, Nordentoft, Merete, Öngür, Dost, Patton, George C., Paus, Tomáš, Reininghaus, Ulrich, Sawa, Akira, Schoenbaum, Michael, Schumann, Gunter, Srihari, Vinod H., Susser, Ezra, Verma, Swapna K., Woo, T. Wilson, Yang, Lawrence H., Yung, Alison R., and Wood, Stephen J.

Published
2023
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36. Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Author

Postema, Merel C, Hoogman, Martine, Ambrosino, Sara, Asherson, Philip, Banaschewski, Tobias, Bandeira, Cibele E, Baranov, Alexandr, Bau, Claiton HD, Baumeister, Sarah, Baur‐Streubel, Ramona, Bellgrove, Mark A, Biederman, Joseph, Bralten, Janita, Brandeis, Daniel, Brem, Silvia, Buitelaar, Jan K, Busatto, Geraldo F, Castellanos, Francisco X, Cercignani, Mara, Chaim‐Avancini, Tiffany M, Chantiluke, Kaylita C, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Cupertino, Renata B, de Zeeuw, Patrick, Doyle, Alysa E, Durston, Sarah, Earl, Eric A, Epstein, Jeffery N, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas J, Faraone, Stephen V, Frodl, Thomas, Gabel, Matt C, Gogberashvili, Tinatin, Grevet, Eugenio H, Haavik, Jan, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hoekstra, Pieter J, Hohmann, Sarah, Høvik, Marie F, Jernigan, Terry L, Kardatzki, Bernd, Karkashadze, Georgii, Kelly, Clare, Kohls, Gregor, Konrad, Kerstin, Kuntsi, Jonna, Lazaro, Luisa, Lera‐Miguel, Sara, Lesch, Klaus‐Peter, Louza, Mario R, Lundervold, Astri J, Malpas, Charles B, Mattos, Paulo, McCarthy, Hazel, Namazova‐Baranova, Leyla, Nicolau, Rosa, Nigg, Joel T, Novotny, Stephanie E, Weiss, Eileen Oberwelland, Tuura, Ruth L O'Gorman, Oosterlaan, Jaap, Oranje, Bob, Paloyelis, Yannis, Pauli, Paul, Picon, Felipe A, Plessen, Kerstin J, Ramos‐Quiroga, J Antoni, Reif, Andreas, Reneman, Liesbeth, Rosa, Pedro GP, Rubia, Katya, Schrantee, Anouk, Schweren, Lizanne JS, Seitz, Jochen, Shaw, Philip, Silk, Tim J, Skokauskas, Norbert, Vila, Juan C Soliva, Stevens, Michael C, Sudre, Gustavo, Tamm, Leanne, Tovar‐Moll, Fernanda, van Erp, Theo GM, Vance, Alasdair, Vilarroya, Oscar, Vives‐Gilabert, Yolanda, von Polier, Georg G, Walitza, Susanne, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, Glahn, David C, and Jahanshad, Neda

Subjects
Biological Psychology, Psychology, Pediatric, Brain Disorders, Mental Health, Neurosciences, Attention Deficit Hyperactivity Disorder (ADHD), Pediatric Research Initiative, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Brain, Caudate Nucleus, Child, Humans, Magnetic Resonance Imaging, Attention&#8208, deficit, hyperactivity disorder, brain asymmetry, brain laterality, structural MRI, large&#8208, scale data, ENIGMA ADHD Working Group, Attention-deficit, large-scale data, Clinical Sciences, Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Applied and developmental psychology, Clinical and health psychology
Abstract

ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.

Published
2021

37. Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Author

Li, Ting, van Rooij, Daan, Mota, Nina Roth, Buitelaar, Jan K, Ambrosino, Sara, Banaschewski, Tobias, Bandeira, Cibele E, Bau, Claiton HD, Baumeister, Sarah, Baur‐Streubel, Ramona, Bellgrove, Mark A, Biederman, Joseph, Bralten, Janita, Bramati, Ivanei E, Brandeis, Daniel, Berm, Silvia, Busatto, Geraldo F, Calvo, Anna, Castellanos, Francisco X, Cercignani, Mara, Chantiluke, Kaylita C, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Cupertino, Renata B, de Zeeuw, Parick, Durston, Sarah, Earl, Eric A, Epstein, Jeffery N, Ethofer, Thomas, Fallgatter, Andreas J, Fair, Damien A, Faraone, Stephen V, Frodl, Thomas, Gabel, Matt C, Gogberashvili, Tinatin, Grevet, Eugenio H, Haavik, Jan, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hoekstra, Pieter J, Høvik, Marie F, Jahanshad, Neda, Kardatzki, Bernd, Karkashadze, Georgii, Kelly, Clare, Kohls, Gregor, Konrad, Kerstin, Kuntsi, Jonna, Lazaro, Luisa, Lera‐Miguel, Sara, Lesch, Klaus‐Peter, Louza, Mario R, Lundervold, Astri J, Malpas, Charles B, Mattos, Paulo, McCarthy, Hazel, Nicolau, Rosa, Nigg, Joel T, Tuura, Ruth L O'Gorman, Oosterlaan, Jaap, Oranje, Bob, Paloyelis, Yannis, Pauli, Paul, Picon, Felipe A, Plessen, Kerstin J, Ramos‐Quiroga, J Antoni, Reif, Andreas, Reneman, Liesbeth, Rosa, Pedro GP, Rubia, Katya, Schrantee, Anouk, Schweren, Lizanne JS, Seitz, Jochen, Shaw, Philip, Silk, Tim J, Skokauskas, Norbert, Vila, Juan Carlos Soliva, Soloveva, Anastasiia, Stevens, Michael C, Sudre, Gustavo, Tamm, Leanne, Thompson, Paul M, Tovar‐Moll, Fernanda, van Erp, Theo GM, Vance, Alasdair, Vilarroya, Oscar, Vives‐Gilabert, Yolanda, von Polier, Georg G, Walitza, Susanne, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, Anikin, Anatoly, Asherson, Philip, Baranov, Alexandr, Chaim‐Avanicini, Tiffany, and Dale, Anders M

Subjects
Biological Psychology, Psychology, Mental Health, Pediatric, Brain Disorders, Attention Deficit Hyperactivity Disorder (ADHD), Clinical Research, Neurosciences, Adult, Attention Deficit Disorder with Hyperactivity, Brain, Case-Control Studies, Female, Humans, Magnetic Resonance Imaging, Male, Thalamus, ADHD, subcortical volume, neuroanatomic heterogeneity, community detection, effect sizes, ENIGMA ADHD Working Group, Clinical Sciences, Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Applied and developmental psychology, Clinical and health psychology
Abstract

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes.MethodsUsing the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks.ResultsExploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men.ConclusionsOur results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.

Published
2021

40. Machine learning classification of conduct disorder with high versus low levels of callous-unemotional traits based on facial emotion recognition abilities

Author

Pauli, Ruth, Kohls, Gregor, Tino, Peter, Rogers, Jack C., Baumann, Sarah, Ackermann, Katharina, Bernhard, Anka, Martinelli, Anne, Jansen, Lucres, Oldenhof, Helena, Gonzalez-Madruga, Karen, Smaragdi, Areti, Gonzalez-Torres, Miguel Angel, Kerexeta-Lizeaga, Iñaki, Boonmann, Cyril, Kersten, Linda, Bigorra, Aitana, Hervas, Amaia, Stadler, Christina, Fernandez-Rivas, Aranzazu, Popma, Arne, Konrad, Kerstin, Herpertz-Dahlmann, Beate, Fairchild, Graeme, Freitag, Christine M., Rotshtein, Pia, and De Brito, Stephane A.

Published
2023
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41. Testing the Ecophenotype Model: Cortical Structure Alterations in Conduct Disorder With Versus Without Childhood Maltreatment

Author

Staginnus, Marlene, Cornwell, Harriet, Toschi, Nicola, Oosterling, Maaike, Paradysz, Michal, Smaragdi, Areti, González-Madruga, Karen, Pauli, Ruth, Rogers, Jack C., Bernhard, Anka, Martinelli, Anne, Kohls, Gregor, Raschle, Nora Maria, Konrad, Kerstin, Stadler, Christina, Freitag, Christine M., De Brito, Stephane A., and Fairchild, Graeme

Published
2023
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42. Long-term safety of methylphenidate in children and adolescents with ADHD: 2-year outcomes of the Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) study

Author

Couper, Tessa, Masi, Gabriele, Gagliano, Antonella, Lamberti, Marco, Maschietto, Dino, Costantino, Antonella, Morosini, Paola, Fazzi, Maria Elisa, Oehler, Klaus-Ulrich, Pitzer, Martina, Fegert, Jörg, Häßler, Frank, Renner, Tobias, Härtling, Fabian, Romanos, Marcel, Alfred, Adam, Roessner, Veit, Wallitza, Susanne, Uebel-von Sandersleben, Henrik, Man, Kenneth K C, Häge, Alexander, Banaschewski, Tobias, Inglis, Sarah K, Buitelaar, Jan, Carucci, Sara, Danckaerts, Marina, Dittmann, Ralf W, Falissard, Bruno, Garas, Peter, Hollis, Chris, Konrad, Kerstin, Kovshoff, Hanna, Liddle, Elizabeth, McCarthy, Suzanne, Neubert, Antje, Nagy, Peter, Rosenthal, Eric, Sonuga-Barke, Edmund J S, Zuddas, Alessandro, Wong, Ian C K, and Coghill, David

Published
2023
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47. The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance

Author

Otten, Katharina Luisa, primary, Edgar, J. Christopher, additional, Green, Heather L., additional, Mol, Kylie, additional, McNamee, Marybeth, additional, Kuschner, Emily S., additional, Kim, Mina, additional, Liu, Song, additional, Huang, Hao, additional, Nordt, Marisa, additional, Konrad, Kerstin, additional, and Chen, Yuhan, additional

Published
2024
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48. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples

Author

Hoogman, Martine, Muetzel, Ryan, Guimaraes, Joao P, Shumskaya, Elena, Mennes, Maarten, Zwiers, Marcel P, Jahanshad, Neda, Sudre, Gustavo, Wolfers, Thomas, Earl, Eric A, Soliva Vila, Juan Carlos, Vives-Gilabert, Yolanda, Khadka, Sabin, Novotny, Stephanie E, Hartman, Catharina A, Heslenfeld, Dirk J, Schweren, Lizanne JS, Ambrosino, Sara, Oranje, Bob, de Zeeuw, Patrick, Chaim-Avancini, Tiffany M, Rosa, Pedro GP, Zanetti, Marcus V, Malpas, Charles B, Kohls, Gregor, von Polier, Georg G, Seitz, Jochen, Biederman, Joseph, Doyle, Alysa E, Dale, Anders M, van Erp, Theo GM, Epstein, Jeffery N, Jernigan, Terry L, Baur-Streubel, Ramona, Ziegler, Georg C, Zierhut, Kathrin C, Schrantee, Anouk, Høvik, Marie F, Lundervold, Astri J, Kelly, Clare, McCarthy, Hazel, Skokauskas, Norbert, O’Gorman Tuura, Ruth L, Calvo, Anna, Lera-Miguel, Sara, Nicolau, Rosa, Chantiluke, Kaylita C, Christakou, Anastasia, Vance, Alasdair, Cercignani, Mara, Gabel, Matt C, Asherson, Philip, Baumeister, Sarah, Brandeis, Daniel, Hohmann, Sarah, Bramati, Ivanei E, Tovar-Moll, Fernanda, Fallgatter, Andreas J, Kardatzki, Bernd, Schwarz, Lena, Anikin, Anatoly, Baranov, Alexandr, Gogberashvili, Tinatin, Kapilushniy, Dmitry, Solovieva, Anastasia, El Marroun, Hanan, White, Tonya, Karkashadze, Georgii, Namazova-Baranova, Leyla, Ethofer, Thomas, Mattos, Paulo, Banaschewski, Tobias, Coghill, David, Plessen, Kerstin J, Kuntsi, Jonna, Mehta, Mitul A, Paloyelis, Yannis, Harrison, Neil A, Bellgrove, Mark A, Silk, Tim J, Cubillo, Ana I, Rubia, Katya, Lazaro, Luisa, Brem, Silvia, Walitza, Susanne, Frodl, Thomas, Zentis, Mariam, Castellanos, Francisco X, Yoncheva, Yuliya N, Haavik, Jan, Reneman, Liesbeth, Conzelmann, Annette, Lesch, Klaus-Peter, Pauli, Paul, Reif, Andreas, Tamm, Leanne, Konrad, Kerstin, Oberwelland Weiss, Eileen, Busatto, Geraldo F, and Louza, Mario R

Subjects
Pediatric, Neurosciences, Mental Health, Attention Deficit Hyperactivity Disorder (ADHD), Behavioral and Social Science, Clinical Research, Brain Disorders, Pediatric Research Initiative, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Adult, Age Factors, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Cerebral Cortex, Child, Child, Preschool, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Psychiatric Status Rating Scales, Sex Factors, Young Adult, Attention Deficit Hyperactivity Disorder, Cortical Surface Area, Cortical Thickness, Imaging, Meta-Analysis, Neuroanatomy, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveNeuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies.MethodsCortical thickness and surface area (based on the Desikan-Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506) were compared. Associations of the attention scale from the Child Behavior Checklist with cortical measures were determined in a pediatric population sample (Generation-R, N=2,707).ResultsIn the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen's d=-0.21). Fusiform gyrus and temporal pole cortical thickness was also lower in children with ADHD. Neither surface area nor thickness differences were found in the adolescent or adult groups. Familial effects were seen for surface area in several regions. In an overlapping set of regions, surface area, but not thickness, was associated with attention problems in the Generation-R sample.ConclusionsSubtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis.

Published
2019

49. Long-term methylphenidate exposure and 24-hours blood pressure and left ventricular mass in adolescents and young adults with attention deficit hyperactivity disorder

Author

Häge, Alexander, Banaschewski, Tobias, Inglis, Sarah K., Carucci, Sara, Danckaerts, Marina, Dittmann, Ralf W., Falissard, Bruno, Garas, Peter, Hollis, Chris, Konrad, Kerstin, Kovshoff, Hanna, Liddle, Elizabeth, McCarthy, Suzanne, Neubert, Antje, Sonuga-Barke, Edmund J.S., Zuddas, Alessandro, Buitelaar, J.K., van de Loo-Neus, G.H.H., Hennissen, L., Greven, C.U., Hoekstra, P.J., Nagy, P., Ramos-Quiroga, A., Rosenthal, E., Kabir, S., Man, K.K.C., IC, Wong, and Coghill, D.

Published
2022
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