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1. Contents Vol. 152, 2010

Author

Hasan Yuksel, En-Chih Liao, Marc A. Riedl, Hirokazu Mizoguchi, Daniel Teschner, Riccardo Asero, Ajax Mercês Atta, Ulrike Körmöczi, Gen Tamura, Yuichi Ohkawara, Alberto Tedeschi, A. Martínez, Kaoru Kusama, Isao Ohno, Kyoko Futamura, Nozomu Ogihara, Massimo Cugno, Peter Steinberger, Erina Lin, İsmail Reisli, Akira Fukumoto, Winfried F. Pickl, Shuhei Fukuda, Yasushi Tomita, Motoaki Takayanagi, Esther von Stebut, Konosuke Omori, Arno Rottal, Kana Wada, Tomoko Nagai, Hirohisa Saito, I. Ibarrola, Shinobu Sakurada, Susetta Finotto, Manabu Nonaka, Manuel Sanchez-Solis, Fernanda Garcia Guerra, Mariana Menezes Pereira, Kaori Okuyama, Kenji Matsumoto, Chiharu Tabata, Mittermayer Barreto Santiago, Klaus G. Schmetterer, Fulya Tahan, Joachim H. Maxeiner, Ahmet Akcay, Yakup Canitez, Ozge Yilmaz, Toshiaki Yagi, Ömer Cevit, Fazil Orhan, Atsuko Sakanushi, Hironori Sagara, J.A. Asturias, Luis Garcia-Marcos, Hiroshi Komatsu, Kanami Orihara, M.C. Arilla, Ruby Pawankar, Sebastian Reuter, Chau-Mei Ho, Markus G. Seidel, Virginia Pérez-Fernández, Rie Tabata, Stephanie Dinges, Ichiro Sora, Maria Sanchez-Bahillo, Noriko Hashimoto, Hideaki Morita, Aysen Bingol Boz, Peri Caucig, Antonia Elena Martinez-Torres, Susanne Matthes-Martin, Nevin Uzuner, Martin D. Chapman, S. Brena, Andrew Saxon, Klaus Schwarz, Christian Taube, Semanur Kuyucu, Maria Luiza B. Sousa Atta, Chrystelle Colas, Demet Can, Jaw-Ji Tsai, and Akio Matsuda

Subjects
Immunology, Immunology and Allergy, General Medicine, Biology
Published
2010

3. Disappearing myelodysplastic syndrome-associated hemolytic anemia in leukemic transformation

Author

Chiharu Tabata, Rie Tabata, Tomoko Nagai, and Konosuke Omori

Subjects
Hemolytic anemia, Male, Myeloid, Reticulocytes, Anemia, Immunology, Autoimmunity, Cell Count, medicine.disease_cause, Methylprednisolone, hemic and lymphatic diseases, Immunopathology, medicine, Immunology and Allergy, Humans, Granulocyte Precursor Cells, Glucocorticoids, Aged, Cell Proliferation, business.industry, Myeloid leukemia, Cancer, General Medicine, medicine.disease, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Cell Transformation, Neoplastic, Myelodysplastic Syndromes, Anemia, Hemolytic, Autoimmune, business
Abstract

Background: Here we report 2 rare cases of acute myeloid leukemia (AML) complicated with hemolytic anemia limited to the myelodysplastic syndrome (MDS) stage, and disappearing in leukemic transformation. Methods/Results: A 66-year-old man with MDS-RAEB-2 was admitted to hospital for severe anemia with increased reticulocyte counts. Hemolytic anemia was suspected, and it was ameliorated by methylprednisolone pulse therapy. Although anemia grew worse when steroids were tapered off, later improvement coincided with an increase in myeloblasts in the peripheral blood, i.e. with leukemic transformation. In another case, a 68-year-old man was admitted to hospital when laboratory findings showed a white blood cell count of 24,800/µl with increased myeloblasts (62.5%), leading to the diagnosis of AML with multilineage dysplasia. Following a decrease in blasts due to anti-cancer drugs, supporting the MDS-RAEB-2 status, severe anemia with increased reticulocytes and positive direct antiglobulin test was diagnosed, suggesting the existence of autoimmune hemolytic anemia, which was then ameliorated by steroid therapy. Conclusions: The simultaneous loss of autoimmunity and leukemic cell expansion observed in our cases may possibly suggest a common underlying mechanism.

Published
2009

4. Autoimmune pancreatitis associated with myelodysplastic syndrome

Author

Makoto Terada, Konosuke Omori, Chiharu Tabata, Tomoko Nagai, Rie Tabata, and Tomoko Okamoto

Subjects
Male, Pancreatic disease, Pancytopenia, Prednisolone, Immunology, medicine.disease_cause, Autoimmunity, Autoimmune Diseases, Bone Marrow, Immunopathology, Azathioprine, medicine, Immunology and Allergy, Humans, Pancreas, Autoimmune pancreatitis, Aged, Autoantibodies, Pancreatic duct, Blood Cells, business.industry, Platelet Count, Autoantibody, Pancreatic Ducts, Bilirubin, General Medicine, Jaundice, medicine.disease, medicine.anatomical_structure, Pancreatitis, Myelodysplastic Syndromes, Amylases, Bile Ducts, medicine.symptom, business
Abstract

A 65-year-old man with myelodysplastic syndrome (MDS) was admitted for progressive jaundice. Diffuse pancreatic swelling and stricture of the main pancreatic duct were observed with elevated serum levels of direct bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, γGTP and amylase, and impaired glucose tolerance. Serum IgG and IgG4 levels were highly elevated, and both the direct antiglobulin test and platelet-associated IgG were positive. He was diagnosed with autoimmune pancreatitis associated with MDS, and biliary drainage followed by immunosuppressive therapy ameliorated the jaundice and laboratory findings. In addition to diffuse pancreatic FDG accumulation, fine incorporations of FDG to the lachrymal and submandibular glands were demonstrated, suggesting the recently proposed IgG4+ multiorgan lymphoproliferative syndrome (MOLPS). The etiology of IgG4+ MOLPS is still unknown; however, autoantibodies to blood cells in this case suggested that the autoimmune mechanism, which is caused by abnormal immune functions in MDS patients, might be involved in the pathogenesis of IgG4+ MOLPS.

Published
2009

5. Subject Index Vol. 152, 2010

Author

Hasan Yuksel, Atsuko Sakanushi, Erina Lin, Yakup Canitez, Ozge Yilmaz, Hirokazu Mizoguchi, Hiroshi Komatsu, Nevin Uzuner, Isao Ohno, Aysen Bingol Boz, Chiharu Tabata, Virginia Pérez-Fernández, Rie Tabata, Hironori Sagara, J.A. Asturias, Shuhei Fukuda, Peri Caucig, Demet Can, Motoaki Takayanagi, Jaw-Ji Tsai, Toshiaki Yagi, Hirohisa Saito, Maria Sanchez-Bahillo, Antonia Elena Martinez-Torres, Nozomu Ogihara, Manuel Sanchez-Solis, Mittermayer Barreto Santiago, Shinobu Sakurada, Kaoru Kusama, Akio Matsuda, Hideaki Morita, Chau-Mei Ho, Marc A. Riedl, Susanne Matthes-Martin, Akira Fukumoto, Yuichi Ohkawara, Stephanie Dinges, A. Martínez, Kyoko Futamura, En-Chih Liao, Ichiro Sora, Ajax Mercês Atta, Martin D. Chapman, S. Brena, Noriko Hashimoto, Kanami Orihara, Ahmet Akcay, M.C. Arilla, Peter Steinberger, Andrew Saxon, Winfried F. Pickl, Alberto Tedeschi, Tomoko Nagai, Klaus Schwarz, Fazil Orhan, I. Ibarrola, Mariana Menezes Pereira, Fernanda Garcia Guerra, Daniel Teschner, Susetta Finotto, Christian Taube, Massimo Cugno, Semanur Kuyucu, Klaus G. Schmetterer, Kaori Okuyama, Fulya Tahan, Ulrike Körmöczi, Ömer Cevit, Ruby Pawankar, İsmail Reisli, Markus G. Seidel, Maria Luiza B. Sousa Atta, Chrystelle Colas, Konosuke Omori, Kana Wada, Joachim H. Maxeiner, Esther von Stebut, Manabu Nonaka, Sebastian Reuter, Riccardo Asero, Kenji Matsumoto, Gen Tamura, Luis Garcia-Marcos, Yasushi Tomita, and Arno Rottal

Subjects
Index (economics), Immunology, Statistics, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2010

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