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Your search keyword '"Konopelski, Piotr"' showing total 16 results
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16 results on '"Konopelski, Piotr"'

3. Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1β and Up-Regulation of Keratins 16 and 17

Author

Konop, Marek, primary, Rybka, Mateusz, additional, Szudzik, Mateusz, additional, Mazurek, Łukasz, additional, Laskowska, Anna K., additional, Sulejczak, Dorota, additional, Ruszczak, Zbigniew, additional, Mazgaj, Rafał, additional, Cieślik, Bartłomiej, additional, Schwartz, Robert A., additional, Samborowska, Emilia, additional, Frankowski, Jakub, additional, Waszkowski, Adam, additional, Konopelski, Piotr, additional, and Czuwara, Joanna, additional

Published
2022
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7. Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1β and Up-Regulation of Keratins 16 and 17.

Author

Konop, Marek, Rybka, Mateusz, Szudzik, Mateusz, Mazurek, Łukasz, Laskowska, Anna K., Sulejczak, Dorota, Ruszczak, Zbigniew, Mazgaj, Rafał, Cieślik, Bartłomiej, Schwartz, Robert A., Samborowska, Emilia, Frankowski, Jakub, Waszkowski, Adam, Konopelski, Piotr, and Czuwara, Joanna

Subjects
KERATIN, HEALING, TIGHT junctions, SKIN regeneration, WOUND healing, TISSUE remodeling, GENE expression
Abstract

Copyright of Journal of Natural Fibers is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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8. Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

Author

Dawidowski, Maciej, primary, Król, Marek, additional, Szulczyk, Bartłomiej, additional, Chodkowski, Andrzej, additional, Podsadni, Piotr, additional, Konopelski, Piotr, additional, Ufnal, Marcin, additional, Szuberski, Piotr, additional, Wróbel, Martyna Zofia, additional, Zhang, Yihong, additional, El Harchi, Aziza, additional, Hancox, Jules C., additional, Jarkovska, Dagmar, additional, Mistrova, Eliska, additional, Sviglerova, Jitka, additional, Štengl, Milan, additional, Popowicz, Grzegorz M., additional, and Turło, Jadwiga, additional

Published
2020
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16. Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats.

Author

Konopelski P, Chabowski D, Aleksandrowicz M, Kozniewska E, Podsadni P, Szczepanska A, and Ufnal M

Subjects
Animals, Autonomic Nervous System drug effects, Autonomic Nervous System physiopathology, Bradycardia chemically induced, Bradycardia physiopathology, Cells, Cultured, Heart Rate drug effects, Humans, Hypertension physiopathology, Indoles administration & dosage, Indoles metabolism, Infusions, Intravenous, Male, Mesenteric Arteries physiopathology, Myocardial Contraction drug effects, Myocytes, Cardiac metabolism, Rats, Inbred WKY, Rats, Arterial Pressure drug effects, Bacteria metabolism, Energy Metabolism drug effects, Gastrointestinal Microbiome, Hypertension chemically induced, Indoles toxicity, Mesenteric Arteries drug effects, Myocytes, Cardiac drug effects
Abstract

Recent evidence suggests that gut bacteria-derived metabolites interact with the cardiovascular system and alter blood pressure (BP) in mammals. Here, we evaluated the effect of indole-3-propionic acid (IPA), a gut bacteria-derived metabolite of tryptophan, on the circulatory system. Arterial BP, electrocardiographic, and echocardiographic (ECHO) parameters were recorded in male, anesthetized, 12-wk-old Wistar-Kyoto rats at baseline and after intravenous administration of either IPA or vehicle. In additional experiments, rats were pretreated with prazosin or pentolinium to evaluate the involvement of the autonomic nervous system in cardiovascular responses to IPA. IPA's concentrations were measured using ultra-high performance liquid chromatography tandem mass spectrometry. The reactivity of endothelium-intact and -denuded mesenteric resistance arteries was tested. Cells' viability and lactate dehydrogenase (LDH) cytotoxicity assays were performed on cultured cardiomyocytes. IPA increased BP with a concomitant bradycardic response but no significant change in QTc interval. The pretreatment with prazosin and pentolinium reduced the hypertensive response. ECHO showed increased contractility of the heart after the administration of IPA. Ex vivo, IPA constricted predilated and endothelium-denuded mesenteric resistance arteries and increased metabolic activity of cardiomyocytes. IPA increases BP via cardiac and vascular mechanisms in rats. Furthermore, IPA increases cardiac contractility and metabolic activity of cardiomyocytes. Our study suggests that IPA may act as a mediator between gut microbiota and the circulatory system.

Published
2021
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