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18 results on '"Konomos, Michael"'

3. Your Family Connects: A Theory-Based Intervention to Encourage Communication about Possible Inherited Cancer Risk among Ovarian Cancer Survivors and Close Relatives

Author

Zhao, Jingsong, primary, McBride, Colleen M., additional, Campbell, Gavin P., additional, Pentz, Rebecca D., additional, Escoffery, Cam, additional, Konomos, Michael, additional, Bellcross, Cecelia, additional, Ward, Kevin, additional, Shepperd, James R., additional, and Guan, Yue, additional

Published
2023
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14. iChoose Kidney

Author

Patzer, Rachel E., primary, Basu, Mohua, additional, Larsen, Christian P., additional, Pastan, Stephen O., additional, Mohan, Sumit, additional, Patzer, Michael, additional, Konomos, Michael, additional, McClellan, William M., additional, Lea, Janice, additional, Howard, David, additional, Gander, Jennifer, additional, and Arriola, Kimberly Jacob, additional

Published
2016
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15. Inhibition of CD8+ T cell derived CD40 signals is necessary but not sufficient for Foxp3+ iTreg induction in vivo

Author

Liu, Danya, Ferrer, Ivana R., Konomos, Michael, and Ford, Mandy L.

Subjects
CD4-Positive T-Lymphocytes, Antigen Presentation, Ovalbumin, CD40 Ligand, Epitopes, T-Lymphocyte, hemic and immune systems, Forkhead Transcription Factors, Dendritic Cells, Skin Transplantation, CD8-Positive T-Lymphocytes, Allografts, Lymphocyte Activation, Adoptive Transfer, Listeria monocytogenes, T-Lymphocytes, Regulatory, Article, Recombinant Proteins, Mice, Inbred C57BL, Mice, T-Lymphocyte Subsets, Animals, Listeriosis, Transplantation Tolerance, CD40 Antigens
Abstract

Current models of CD4(+) T cell help suggest a major role for CD154 binding to CD40 expressed on dendritic cells, with a lesser role for direct T:T interactions via CD40 expressed on CD8(+) T cells. However, the contribution of CD8(+) T cell-derived CD40 signals during the donor-reactive T cell response to a transplant has never been studied. In this study, we examined the graft-rejection kinetics and CD4(+) and CD8(+) donor-reactive T cell responses under conditions in which CD40 was genetically ablated only on APC, as well as under conditions in which CD40 was genetically ablated only on donor-reactive CD8(+) T cells. Our results revealed a significant role for CD8(+) T cell-expressed CD40 in the augmentation of donor-reactive CD8(+) T cell responses following transplantation and showed that CD40 expressed on CD8(+) T cells must be inhibited to allow conversion of CD4(+) T cells into induced regulatory T cells. Thus, this study identifies a major role for CD8(+) T cell-derived CD40 signals as a critical switch factor that both promotes optimal differentiation of cytokine-producing CD8(+) effector T cell responses and inhibits the differentiation of Ag-specific Foxp3(+) induced regulatory T cells in vivo.

Published
2013

18. Inhibition of CD8+ T Cell-Derived CD40 Signals Is Necessary but Not Sufficient for Foxp3+ Induced Regulatory T Cell Generation In Vivo.

Author

Liu, Danya, Ferrer, Ivana R., Konomos, Michael, and Ford, Mandy L.

Subjects
*CD8 antigen, *T cells, *CD40 antigen, *IMMUNE response, *DENDRITIC cells, *GRAFT rejection
Abstract

Current models of CD4+ T cell help suggest a major role for CD154 binding to CD40 expressed on dendritic cells, with a lesser role for direct T:T interactions via CD40 expressed on CD8+ T cells. However, the contribution of CD8+ T cell-derived CD40 signals during the donor-reactive T cell response to a transplant has never been studied. In this study, we examined the graft-rejection kinetics and CD4+ and CD8+ donor-reactive T cell responses under conditions in which CD40 was genetically ablated only on APC, as well as under conditions in which CD40 was genetically ablated only on donor-reactive CD8+ T cells. Our results revealed a significant role for CD8+ T cell-expressed CD40 in the augmentation of donor-reactive CD8+ T cell responses following transplantation and showed that CD40 expressed on CD8+ T cells must be inhibited to allow conversion of CD4+ T cells into induced regulatory T cells. Thus, this study identifies a major role for CD8+ T cell-derived CD40 signals as a critical switch factor that both promotes optimal differentiation of cytokine-producing CD8+ effector T cell responses and inhibits the differentiation of Ag-specific Foxp3+ induced regulatory T cells in vivo. [ABSTRACT FROM AUTHOR]

Published
2013
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