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34 results on '"Konishi, Noriaki"'

10. Systemic stress increases serum leptin level

Author

Konishi, Noriaki, Otaka, Michiro, Odashima, Masaru, Jin, Mario, Wada, Isao, Komatsu, Koga, Sato, Toshihiro, Kato, Sayuri, Matsuhashi, Tamotsu, and Watanabe, Sumio

Published
2006

19. Expression of a 72-kDa heat shock protein and protection in gastric mucosa of portal hypertensive rats

Author

Watanabe, Daisuke, primary, Mikami, Ken-Ichiro, additional, Yoneyama, Kazuo, additional, Goto, Takashi, additional, Miura, Kouichi, additional, Ohshima, Shigetoshi, additional, Lin, Jiun-Guey, additional, Segawa, Daisuke, additional, Kataoka, Ei, additional, Konishi, Noriaki, additional, Odashima, Masaru, additional, Sugawara, Masashiro, additional, Otaka, Michiro, additional, and Watanabe, Sumio, additional

Published
2003
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32. FR167653, a potent suppressant of interleukin-1 and tumor necrosis factor-α production, ameliorates colonic lesions in experimentally induced acute colitis1.

Author

Blandino, Ivan I Pacheco, Otaka, Michiro, Jin, Mario, Komatsu, Koga, Odashima, Masaru, Konishi, Noriaki, Sato, Toshihiro, Kato, Sayuri, and Watanabe, Sumio

Subjects
LARGE intestine diseases, INTERLEUKIN-1, TUMOR necrosis factors
Abstract

AbstractBackground: Interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) are believed to play a significant role in the pathogenesis of inflammatory bowel disease (IBD). Interleukin-1 and TNF-α possess overlapping and synergetic activities inducing the production in cascade of other cytokines, adhesion molecules, arachidonic acid metabolites, as well as activating immune and non-immune cells. FR167653 (C24H18FN5O2.H2SO4.H2O) is a newly synthesized organic compound with a potent inhibitory effect on IL-1β and TNF-α production. We hypothesized that the suppression of IL-1 and TNF-α induced by FR167653 could effectively attenuate experimentally induced colonic damage. Methods: Colonic lesions were induced in male Sprague–Dawley rats (250–300 g) by intrarectal instillation of 4% acetic acid. The effect of FR167653 administration at 1.0, 1.5, 2.5 mg/kg per 6 h subcutaneously on acetic acid-induced colonic damage was assessed. The lesion area, microscopic findings, colonic and serum levels of TNF-α and IL-1β were also evaluated. Results: Treatment with FR167653 at 1.5 and 2.5 mg/kg per 6 h was able to ameliorate the gross macroscopic appearance of colonic lesions significantly, as well as ameliorate the lesion area induced by acetic acid. Colonic mucosal TNF-α and IL-1β levels of rats treated with FR167653 showed significant decrease in a dose-dependent fashion compared with the control group. In the same manner, serum TNF-α of rats treated with FR167653 was significantly lower than that of respective controls. Conclusions: Subcutaneous administration of FR167653 was able to ameliorate the acute changes induced by acetic acid instillation in a dose-dependent manner. This is the first report to evaluate the dual inhibition of the production of IL-1 and TNF-α, offered by FR167653, in acute experimental colitis.... [ABSTRACT FROM AUTHOR]

Published
2001
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34. FR167653, a potent suppressant of interleukin-1 and tumor necrosis factor-α production, ameliorates colonic lesions in experimentally induced acute colitis1.

Author

Blandino, Ivan I Pacheco, Otaka, Michiro, Jin, Mario, Komatsu, Koga, Odashima, Masaru, Konishi, Noriaki, Sato, Toshihiro, Kato, Sayuri, and Watanabe, Sumio

Subjects
*LARGE intestine diseases, *INTERLEUKIN-1, *TUMOR necrosis factors
Abstract

AbstractBackground: Interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) are believed to play a significant role in the pathogenesis of inflammatory bowel disease (IBD). Interleukin-1 and TNF-α possess overlapping and synergetic activities inducing the production in cascade of other cytokines, adhesion molecules, arachidonic acid metabolites, as well as activating immune and non-immune cells. FR167653 (C24H18FN5O2.H2SO4.H2O) is a newly synthesized organic compound with a potent inhibitory effect on IL-1β and TNF-α production. We hypothesized that the suppression of IL-1 and TNF-α induced by FR167653 could effectively attenuate experimentally induced colonic damage. Methods: Colonic lesions were induced in male Sprague–Dawley rats (250–300 g) by intrarectal instillation of 4% acetic acid. The effect of FR167653 administration at 1.0, 1.5, 2.5 mg/kg per 6 h subcutaneously on acetic acid-induced colonic damage was assessed. The lesion area, microscopic findings, colonic and serum levels of TNF-α and IL-1β were also evaluated. Results: Treatment with FR167653 at 1.5 and 2.5 mg/kg per 6 h was able to ameliorate the gross macroscopic appearance of colonic lesions significantly, as well as ameliorate the lesion area induced by acetic acid. Colonic mucosal TNF-α and IL-1β levels of rats treated with FR167653 showed significant decrease in a dose-dependent fashion compared with the control group. In the same manner, serum TNF-α of rats treated with FR167653 was significantly lower than that of respective controls. Conclusions: Subcutaneous administration of FR167653 was able to ameliorate the acute changes induced by acetic acid instillation in a dose-dependent manner. This is the first report to evaluate the dual inhibition of the production of IL-1 and TNF-α, offered by FR167653, in acute experimental colitis.... [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
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