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10 results on '"Konishi, Aki"'

2. B cell‐intrinsic MyD88 signaling controls IFN‐γ‐mediated early IgG2c class switching in mice in response to a particulate adjuvant

Author

Lee, Michelle Sue Jann, primary, Natsume‐Kitatani, Yayoi, additional, Temizoz, Burcu, additional, Fujita, Yukiko, additional, Konishi, Aki, additional, Matsuda, Kyoko, additional, Igari, Yoshikatsu, additional, Tsukui, Toshihiro, additional, Kobiyama, Kouji, additional, Kuroda, Etsushi, additional, Onishi, Motoyasu, additional, Marichal, Thomas, additional, Ise, Wataru, additional, Inoue, Takeshi, additional, Kurosaki, Tomohiro, additional, Mizuguchi, Kenji, additional, Akira, Shizuo, additional, Ishii, Ken J, additional, and Coban, Cevayir, additional

Published
2019
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3. Plasmodium products persist in the bone marrow and promote chronic bone loss

Author

Lee, Michelle S. J., primary, Maruyama, Kenta, additional, Fujita, Yukiko, additional, Konishi, Aki, additional, Lelliott, Patrick M., additional, Itagaki, Sawako, additional, Horii, Toshihiro, additional, Lin, Jing-wen, additional, Khan, Shahid M., additional, Kuroda, Etsushi, additional, Akira, Shizuo, additional, Ishii, Ken J., additional, and Coban, Cevayir, additional

Published
2017
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5. Plasmodium products persist in the bone marrow and promote chronic bone loss.

Author

J. Lee, Michelle S., Kenta Maruyama, Yukiko Fujita, Konishi, Aki, Lelliott, Patrick M., Sawako Itagaki, Toshihiro Horii, Jing-wen Lin, Khan, Shahid M., Etsushi Kuroda, Shizuo Akira, Ishii, Ken J., and Coban, Cevayir

Subjects
PLASMODIUM, BONE marrow, BONE diseases, MALARIA prevention, MALARIA immunology, DWARFISM, DISEASE risk factors
Abstract

Although malaria is a life-threatening disease with severe complications, most people develop partial immunity and suffer from mild symptoms. However, incomplete recovery from infection causes chronic illness, and little is known of the potential outcomes of this chronicity. We found that malaria causes bone loss and growth retardation as a result of chronic bone inflammation induced by Plasmodium products. Acute malaria infection severely suppresses bone homeostasis, but sustained accumulation of Plasmodium products in the bone marrow niche induces MyD88-dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression and overstimulation of osteoclastogenesis, favoring bone resorption. Infection with a mutant parasite with impaired hemoglobin digestion that produces little hemozoin, a major Plasmodium by-product, did not cause bone loss. Supplementation of alfacalcidol, a vitamin D3 analog, could prevent the bone loss. These results highlight the risk of bone loss in malaria-infected patients and the potential benefits of coupling bone therapy with antimalarial treatment. [ABSTRACT FROM AUTHOR]

Published
2017
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6. Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria

Author

Zhao, Hong, primary, Aoshi, Taiki, additional, Kawai, Satoru, additional, Mori, Yuki, additional, Konishi, Aki, additional, Ozkan, Muge, additional, Fujita, Yukiko, additional, Haseda, Yasunari, additional, Shimizu, Mikiko, additional, Kohyama, Masako, additional, Kobiyama, Kouji, additional, Eto, Kei, additional, Nabekura, Junichi, additional, Horii, Toshihiro, additional, Ishino, Tomoko, additional, Yuda, Masao, additional, Hemmi, Hiroaki, additional, Kaisho, Tsuneyasu, additional, Akira, Shizuo, additional, Kinoshita, Manabu, additional, Tohyama, Koujiro, additional, Yoshioka, Yoshichika, additional, Ishii, Ken J., additional, and Coban, Cevayir, additional

Published
2014
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8. Lipocalin 2 Bolsters Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection by Reinforcing Host Iron Metabolism

Author

Zhao, Hong, primary, Konishi, Aki, additional, Fujita, Yukiko, additional, Yagi, Masanori, additional, Ohata, Keiichi, additional, Aoshi, Taiki, additional, Itagaki, Sawako, additional, Sato, Shintaro, additional, Narita, Hirotaka, additional, Abdelgelil, Noha H., additional, Inoue, Megumi, additional, Culleton, Richard, additional, Kaneko, Osamu, additional, Nakagawa, Atsushi, additional, Horii, Toshihiro, additional, Akira, Shizuo, additional, Ishii, Ken J., additional, and Coban, Cevayir, additional

Published
2012
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9. A New System for the Analysis of Thermal Judgments: Multipoint Measurements of Skin Temperatures and Temperature-Related Sensations and Their Joint Visualization

Author

Nakamura, Mayumi, primary, Esaki, Hidenori, additional, Yoda, Tamae, additional, Yasuhara, Saki, additional, Kobayashi, Akiko, additional, Konishi, Aki, additional, Osawa, Naoki, additional, Nagashima, Kei, additional, Crawshaw, Larry I., additional, and Kanosue, Kazuyuki, additional

Published
2006
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