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2. Electrodiagnostic subtyping in Guillain–Barré syndrome patients in the International Guillain–Barré Outcome Study

Author

Arends, S, Drenthen, J, de Koning, L, van den Bergh, P, Hadden, R, Kuwabara, S, Reisin, R, Shahrizaila, N, Ajroud-Driss, S, Antonini, G, Attarian, S, Balducci, C, Bertorini, T, Brannagan, T, Cavaletti, G, Chao, C, Chavada, G, Dillmann, K, Dimachkie, M, Galassi, G, Gutierrez-Gutierrez, G, Harbo, T, Islam, B, Islam, Z, Katzberg, H, Kusunoki, S, Manganelli, F, Miller, J, Pardo, J, Pereon, Y, Rajabally, Y, Sindrup, S, Stettner, M, Uncini, A, Verhamme, C, Vytopil, M, Waheed, W, Jacobs, B, Cornblath, D, Addington, J, Badrising, U, Barroso, F, Bateman, K, Bella, I, Benedetti, L, van den Berg, B, Bhavaraju-Sanka, R, Briani, C, Buermann, J, Busby, M, Butterworth, S, Casasnovas, C, Chen, S, Claeys, K, Conti, E, Cosgrove, J, Dalakas, M, van Damme, P, Dardiotis, E, Davidson, A, Doets, A, van Doorn, P, Echaniz-Laguna, A, Eftimov, F, Faber, K, Fazio, R, Feasby, T, Fehmi, J, Fokke, C, Fujioka, T, Fulgenzi, E, Garssen, M, Gijsbers, C, Gilchrist, J, Gilhuis, J, Goldstein, J, Gorson, K, Goyal, N, Granit, V, Gutmann, L, Hartung, H, Holt, J, Hsieh, S, Htut, M, Hughes, R, Jerico-Pascual, I, Kaida, K, Karafiath, S, Khoshnoodi, M, Kiers, L, Kleiweg, R, Kokubun, N, Kolb, N, van Koningsveld, R, van der Kooi, A, Kramers, H, Kuitwaard, K, Kwan, J, Ladha, S, Lassen, L, Lawson, V, Lehmann, H, Cejas, L, Leonhard, S, Luijten, L, Lunn, M, Manji, H, Marfia, G, Infante, C, Martin-Aguilar, L, Martinez-Hernandez, E, Mataluni, G, Mattiazzi, M, Mcdermott, C, Meekins, G, Mohammad, Q, Monges, S, de la Tassa, G, Nascimbene, C, Nobile-Orazio, E, Nowak, R, Osei-Bonsu, M, Pelouto, F, Pulley, M, Gutierrez, L, Reddel, S, van der Ree, T, Rinaldi, S, Ripellino, P, Roberts, R, Rojas-Marcos, I, Roodbol, J, Rudnicki, S, Sachs, G, Samijn, J, Santoro, L, Schenone, A, Tous, M, Sheikh, K, Silvestri, N, Sundrup, S, Sommer, C, Stein, B, Stino, A, Thomma, R, Twydell, P, Varrato, J, Vermeij, F, Verschuuren, J, Visser, L, Walgaard, C, Wang, Y, Willison, H, Wirtz, P, van Woerkom, M, Zivkovic, S, Arends S., Drenthen J., de Koning L., van den Bergh P., Hadden R. D. M., Kuwabara S., Reisin R. C., Shahrizaila N., Ajroud-Driss S., Antonini G., Attarian S., Balducci C., Bertorini T., Brannagan T. H., Cavaletti G., Chao C. -C., Chavada G., Dillmann K. -U., Dimachkie M. M., Galassi G., Gutierrez-Gutierrez G., Harbo T., Islam B., Islam Z., Katzberg H., Kusunoki S., Manganelli F., Miller J. A. L., Pardo J., Pereon Y., Rajabally Y. A., Sindrup S., Stettner M., Uncini A., Verhamme C., Vytopil M., Waheed W., Jacobs B. C., Cornblath D. R., Addington J. M., Badrising U. A., Barroso F. A., Bateman K., Bella I., Benedetti L., van den Berg B., Bhavaraju-Sanka R., Briani C., Buermann J., Busby M., Butterworth S., Casasnovas C., Chen S., Claeys K., Conti E., Cosgrove J. S., Dalakas M., van Damme P., Dardiotis E., Davidson A., Doets A., van Doorn P., Echaniz-Laguna A., Eftimov F., Faber K. G., Fazio R., Feasby T. E., Fehmi J., Fokke C., Fujioka T., Fulgenzi E., Garssen M. P. J., Gijsbers C. J., Gilchrist J. M., Gilhuis J., Goldstein J. M., Gorson K. C., Goyal N., Granit V., Gutmann L., Hartung H. -P., Holt J. K. L., Hsieh S. -T., Htut M., Hughes R. A. C., Jerico-Pascual I., Kaida K., Karafiath S., Khoshnoodi M. A., Kiers L., Kleiweg R. P., Kokubun N., Kolb N. A., van Koningsveld R., van der Kooi A. J., Kramers H., Kuitwaard K., Kwan J. Y., Ladha S. S., Lassen L. L., Lawson V. H., Lehmann H., Cejas L. L., Leonhard S. E., Luijten L., Lunn M. P. T., Manji H., Marfia G. A., Infante C. M., Martin-Aguilar L., Martinez-Hernandez E., Mataluni G., Mattiazzi M., McDermott C., Meekins G., Mohammad Q. D., Monges S., de la Tassa G. M., Nascimbene C., Nobile-Orazio E., Nowak R. J., Osei-Bonsu M., Pelouto F., Pulley M. T., Gutierrez L. Q., Reddel S. W., van der Ree T., Rinaldi S., Ripellino P., Roberts R. C., Rojas-Marcos I., Roodbol J., Rudnicki S. A., Sachs G. M., Samijn J. P. A., Santoro L., Schenone A., Tous M. J. S., Sheikh K. A., Silvestri N. J., Sundrup S. H., Sommer C., Stein B., Stino A. M., Thomma R. C. M., Twydell P., Varrato J. D., Vermeij F. H., Verschuuren J., Visser L. H., Walgaard C., Wang Y., Willison H. J., Wirtz P. W., van Woerkom M., Zivkovic S. A., Arends, S, Drenthen, J, de Koning, L, van den Bergh, P, Hadden, R, Kuwabara, S, Reisin, R, Shahrizaila, N, Ajroud-Driss, S, Antonini, G, Attarian, S, Balducci, C, Bertorini, T, Brannagan, T, Cavaletti, G, Chao, C, Chavada, G, Dillmann, K, Dimachkie, M, Galassi, G, Gutierrez-Gutierrez, G, Harbo, T, Islam, B, Islam, Z, Katzberg, H, Kusunoki, S, Manganelli, F, Miller, J, Pardo, J, Pereon, Y, Rajabally, Y, Sindrup, S, Stettner, M, Uncini, A, Verhamme, C, Vytopil, M, Waheed, W, Jacobs, B, Cornblath, D, Addington, J, Badrising, U, Barroso, F, Bateman, K, Bella, I, Benedetti, L, van den Berg, B, Bhavaraju-Sanka, R, Briani, C, Buermann, J, Busby, M, Butterworth, S, Casasnovas, C, Chen, S, Claeys, K, Conti, E, Cosgrove, J, Dalakas, M, van Damme, P, Dardiotis, E, Davidson, A, Doets, A, van Doorn, P, Echaniz-Laguna, A, Eftimov, F, Faber, K, Fazio, R, Feasby, T, Fehmi, J, Fokke, C, Fujioka, T, Fulgenzi, E, Garssen, M, Gijsbers, C, Gilchrist, J, Gilhuis, J, Goldstein, J, Gorson, K, Goyal, N, Granit, V, Gutmann, L, Hartung, H, Holt, J, Hsieh, S, Htut, M, Hughes, R, Jerico-Pascual, I, Kaida, K, Karafiath, S, Khoshnoodi, M, Kiers, L, Kleiweg, R, Kokubun, N, Kolb, N, van Koningsveld, R, van der Kooi, A, Kramers, H, Kuitwaard, K, Kwan, J, Ladha, S, Lassen, L, Lawson, V, Lehmann, H, Cejas, L, Leonhard, S, Luijten, L, Lunn, M, Manji, H, Marfia, G, Infante, C, Martin-Aguilar, L, Martinez-Hernandez, E, Mataluni, G, Mattiazzi, M, Mcdermott, C, Meekins, G, Mohammad, Q, Monges, S, de la Tassa, G, Nascimbene, C, Nobile-Orazio, E, Nowak, R, Osei-Bonsu, M, Pelouto, F, Pulley, M, Gutierrez, L, Reddel, S, van der Ree, T, Rinaldi, S, Ripellino, P, Roberts, R, Rojas-Marcos, I, Roodbol, J, Rudnicki, S, Sachs, G, Samijn, J, Santoro, L, Schenone, A, Tous, M, Sheikh, K, Silvestri, N, Sundrup, S, Sommer, C, Stein, B, Stino, A, Thomma, R, Twydell, P, Varrato, J, Vermeij, F, Verschuuren, J, Visser, L, Walgaard, C, Wang, Y, Willison, H, Wirtz, P, van Woerkom, M, Zivkovic, S, Arends S., Drenthen J., de Koning L., van den Bergh P., Hadden R. D. M., Kuwabara S., Reisin R. C., Shahrizaila N., Ajroud-Driss S., Antonini G., Attarian S., Balducci C., Bertorini T., Brannagan T. H., Cavaletti G., Chao C. -C., Chavada G., Dillmann K. -U., Dimachkie M. M., Galassi G., Gutierrez-Gutierrez G., Harbo T., Islam B., Islam Z., Katzberg H., Kusunoki S., Manganelli F., Miller J. A. L., Pardo J., Pereon Y., Rajabally Y. A., Sindrup S., Stettner M., Uncini A., Verhamme C., Vytopil M., Waheed W., Jacobs B. C., Cornblath D. R., Addington J. M., Badrising U. A., Barroso F. A., Bateman K., Bella I., Benedetti L., van den Berg B., Bhavaraju-Sanka R., Briani C., Buermann J., Busby M., Butterworth S., Casasnovas C., Chen S., Claeys K., Conti E., Cosgrove J. S., Dalakas M., van Damme P., Dardiotis E., Davidson A., Doets A., van Doorn P., Echaniz-Laguna A., Eftimov F., Faber K. G., Fazio R., Feasby T. E., Fehmi J., Fokke C., Fujioka T., Fulgenzi E., Garssen M. P. J., Gijsbers C. J., Gilchrist J. M., Gilhuis J., Goldstein J. M., Gorson K. C., Goyal N., Granit V., Gutmann L., Hartung H. -P., Holt J. K. L., Hsieh S. -T., Htut M., Hughes R. A. C., Jerico-Pascual I., Kaida K., Karafiath S., Khoshnoodi M. A., Kiers L., Kleiweg R. P., Kokubun N., Kolb N. A., van Koningsveld R., van der Kooi A. J., Kramers H., Kuitwaard K., Kwan J. Y., Ladha S. S., Lassen L. L., Lawson V. H., Lehmann H., Cejas L. L., Leonhard S. E., Luijten L., Lunn M. P. T., Manji H., Marfia G. A., Infante C. M., Martin-Aguilar L., Martinez-Hernandez E., Mataluni G., Mattiazzi M., McDermott C., Meekins G., Mohammad Q. D., Monges S., de la Tassa G. M., Nascimbene C., Nobile-Orazio E., Nowak R. J., Osei-Bonsu M., Pelouto F., Pulley M. T., Gutierrez L. Q., Reddel S. W., van der Ree T., Rinaldi S., Ripellino P., Roberts R. C., Rojas-Marcos I., Roodbol J., Rudnicki S. A., Sachs G. M., Samijn J. P. A., Santoro L., Schenone A., Tous M. J. S., Sheikh K. A., Silvestri N. J., Sundrup S. H., Sommer C., Stein B., Stino A. M., Thomma R. C. M., Twydell P., Varrato J. D., Vermeij F. H., Verschuuren J., Visser L. H., Walgaard C., Wang Y., Willison H. J., Wirtz P. W., van Woerkom M., and Zivkovic S. A.

Abstract

Background and purpose: Various electrodiagnostic criteria have been developed in Guillain–Barré syndrome (GBS). Their performance in a broad representation of GBS patients has not been evaluated. Motor conduction data from the International GBS Outcome Study (IGOS) cohort were used to compare two widely used criterion sets and relate these to diagnostic amyotrophic lateral sclerosis criteria. Methods: From the first 1500 patients in IGOS, nerve conduction studies from 1137 (75.8%) were available for the current study. These patients were classified according to nerve conduction studies criteria proposed by Hadden and Rajabally. Results: Of the 1137 studies, 68.3% (N = 777) were classified identically according to criteria by Hadden and Rajabally: 111 (9.8%) axonal, 366 (32.2%) demyelinating, 195 (17.2%) equivocal, 35 (3.1%) inexcitable and 70 (6.2%) normal. Thus, 360 studies (31.7%) were classified differently. The areas of differences were as follows: 155 studies (13.6%) classified as demyelinating by Hadden and axonal by Rajabally; 122 studies (10.7%) classified as demyelinating by Hadden and equivocal by Rajabally; and 75 studies (6.6%) classified as equivocal by Hadden and axonal by Rajabally. Due to more strictly defined cutoffs fewer patients fulfilled demyelinating criteria by Rajabally than by Hadden, making more patients eligible for axonal or equivocal classification by Rajabally. In 234 (68.6%) axonal studies by Rajabally the revised El Escorial (amyotrophic lateral sclerosis) criteria were fulfilled; in axonal cases by Hadden this was 1.8%. Conclusions and discussion: This study shows that electrodiagnosis in GBS is dependent on the criterion set utilized, both of which are based on expert opinion. Reappraisal of electrodiagnostic subtyping in GBS is warranted.

Published
2024

4. The effect of ribwort plantain (Plantago lanceolata) on enteric methane emission during grazing

Author

Koning, L., Holshof, G., Klop, A., Klootwijk, C.W., Koning, L., Holshof, G., Klop, A., and Klootwijk, C.W.

Abstract

Herb-rich grasslands are of increasing interest due to their potential properties for reducing enteric methane (CH4) emission and increasing biodiversity. The objective of this study was to compare enteric CH4 emission of cows grazing on perennial ryegrass (Lolium perenne, LP) pastures with and without ribwort plantain (Plantago lanceolata, PL). Thirty-two dairy cows were blocked and assigned to one of the treatments: LP and LP with PL (LP-PL) in Duplo on adjacent pastures that received the same grassland management. Cows were continuously grazing for four weeks per period: two weeks of adaptation and two weeks of measurement period. The trial was repeated three times in 2022: May-Jun (period 1), Jul-Aug (period 2) and Sept-Oct (period 3). Enteric CH4 emission was measured using GreenFeed. A restricted maximum likelihood (REML) analysis was done with pasture and botanical composition (LP / LP-PL) as fixed effects and block as random effect. The CH4 production and yield was significantly higher for LP-PL compared to LP (P<0.001 and P=0.046, respectively). This study did not show a CH4 reduction potential of PL, but that may be due to the low proportion of PL in the pasture and the possibility for cows to select while grazing.

Published
2024

5. Minimum number of spot measurements required for quantifying enteric methane production in dairy cattle

Author

Koning, L., van Gastelen, S., Burgers, E.E.A., Klootwijk, C.W., Bannink, A., Dijkstra, J., Koning, L., van Gastelen, S., Burgers, E.E.A., Klootwijk, C.W., Bannink, A., and Dijkstra, J.

Abstract

The GreenFeed system (GF; C-Lock) has been developed as a static short-term measurement device for enteric methane (CH 4) emission from individual animals. The objective of this study was to define the minimum number of GF spot measurements required to obtain reliable CH 4 production measurements in dairy cattle in three different systems: fresh grass outdoors (G), fresh grass indoors (ZG) and grass silage indoors (GS). Simple random sampling without replacement was used to analyse 9426 CH4 spot measurements obtained from 138 measurement units (100 dairy cows). For each cow with more than 30 spot measurements per two-week measurement period, 100 replicates of 1 to 30 spot measurements were randomly selected to calculate the mean absolute percentage error (MAPE) for each combination of replicate and spot measurement count. A minimum of 17, 10 and 11 spot measurements is needed for G, ZG and GS, respectively, to prevent a MAPE larger than 4%. In conclusion, a larger number of spot measurements with the GF is needed for grazing studies compared to studies indoors to attain reliable enteric CH4 production measurements in dairy cattle.

Published
2024

6. Fresh grass diets supplemented with essential oils for dairy cows: effects on milk and urea

Author

Burgers, E.E.A., Klop, A., Koning, L., Holshof, G., Klootwijk, C.W., Burgers, E.E.A., Klop, A., Koning, L., Holshof, G., and Klootwijk, C.W.

Abstract

This study evaluated the effect of essential oils (EO) on fat-and-protein corrected milk (FPCM) andmilk urea of 42 cows in 3 systems: (1) fresh grass outdoors (day and night grazing, n=14); (2) fresh grass outdoors during the day, grass silage indoors at night (daytime grazing, n=14); and (3) fresh grass indoors during the day, grass silage indoors at night (daytime zero grazing, n=14). In every system, half of the number of cows were fed a concentrate with EO, the other half was fed a concentrate without EO. The study consisted of 2 periods in the growing season, both with 2 weeks acclimatisation and 2 weeks measurements. The concentrate with or without EO was fed during both complete periods and the 2 weeks measurements were analysed. For cows receiving EO, the FPCM was 30.9 kg day –1 and milk urea was 19.5 mg dL, compared with 30.4 kg day–1 (P=0.42) and 19.7 mg dl–1 (P=0.75) for cows not receiving EO. Feeding EO did not affect FPCM and milk urea in different grazing systems between April and July, although numerically FPCM was a bit higher and milk urea was a bit lower.

Published
2024

8. Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war

Author

Agulnik, A, Kizyma, R, Salek, M, Wlodarski, M, Pogorelyy, M, Oszer, A, Yakimkova, T, Nogovitsyna, Y, Dutkiewicz, M, Dalle, J, Dirksen, U, Eggert, A, Fernandez-Teijeiro, A, Greiner, J, Kraal, K, Mueller, A, Sramkova, L, Zecca, M, Wise, P, Mlynarski, W, Avula, M, Adyrov, M, Berlanga, P, Blackwood, C, Bouffet, E, Czauderna, P, de Koning, L, dos Reis Farinha, N, Foster, W, Graetz, D, Gupta, S, Holter, W, Hough, R, Kliuchkivska, K, Kolenova, A, Kolodrubiec, J, Moreira, D, Mukkada, S, Mykychak, I, Raciborska, A, Salman, Z, Sopilnyak, A, Tyupa, S, Vinitsky, A, Wobst, N, Miller, B, Rasul, S, Rodriguez-Galindo, C, Alanbousi, I, Alexander, S, Apel, A, Bal, W, Balwierz, W, Basset-Salom, L, Bastardo Blanco, D, Bauer, K, Bayazitov, I, Bhakta, N, Bien, E, Bieniek, K, Blair, S, Bodak, K, Bordeianu, I, Braganca, J, Bucurenci, M, Budny, E, Budzyn, A, Bumgardner, C, Burditt, R, Burnside Clapp, V, Bykov, V, Canete, A, Carnelli, M, Cela, E, Cepowska, Z, Chaber, R, Cherner-Drieux, A, Chubata, M, Clough, H, Czernicka - Siwecka, J, Czyzewski, K, Dashchakovska, O, Dembowska-Baginska, B, Derwich, K, Dommett, R, Dorosh, O, Drabko, K, Dragomir, M, Dworzak, M, Dyma, S, Earl, J, English, M, Evseev, D, Farren, B, Fedyk, N, Ferneza, S, Fox Irwin, L, Galazkowski, R, Ganieva, G, Garanzha, V, Gelman, M, Godzinski, J, Goeres, A, Golban, R, Griksaitis, M, Hampel, M, Hastings, S, Heenen, D, Hill, M, Holiuk, I, Hutnik, L, Irga-Jaworska, N, Istomin, O, Janczar, S, Kacharian, A, Kalwak, K, Karolczyk, G, Karpenko, N, Katsubo, H, Kaznowska, B, Kentsis, A, Ketteler, P, Kienesberger, A, Kiselev, R, Kizyma, Z, Klymniuk, H, Kostiuk, Y, Kowalik, T, Kozlova, O, Kozubenko, V, Kramar, T, Krawczuk-Rybak, M, Kulemzina, I, Kurkowska, P, Kuzyk, A, Ladenstein, R, Laguna, P, Lassaletta, A, Lehmberg, K, Leontieva, O, Liashenko, S, Loizou, L, Lucchetta, S, Lupo, M, Lysytsia, L, Lysytsia, O, Machnik, K, Mainland, J, Matczak, K, Matysiak, M, Mayeur, P, Minervina, A, Mishkova, V, Mizia-Malarz, A, Morales La Madrid, A, Moreno, L, Moskvin, V, Muszynska-Roslan, K, Nelson, A, Ociepa, T, Oltolini, S, Onipko, N, Pappas, A, Patel, A, Patrahau, A, Pauley, J, Pavlenko, Y, Pavlovych, A, Peregud-Pogorzelski, J, Perek-Polnik, M, Perez, V, Perez-Martinez, A, Pikman, Y, Pitozzi, G, Portugal, R, Posternak, V, Prete, A, Pritchard-Jones, K, Radaelli, A, Reeves, T, Reinhardt, D, Reshetnyak, A, Rider, A, Rizzari, C, Rizzi, D, Rodriguez Hermosillo, K, Ronenko, O, Rostowska, A, Rudko, L, Sakaan, F, Sakhar, N, Savva, N, Scaccaglia, D, Schaeffer, E, Schneider, C, Scobie, N, Semeniuk, O, Shevchyk, R, Shuler, A, Shvets, S, Skoczen, S, Smeal, W, Sokolowski, I, Sonkin, A, Stepanjuk, A, Spota, A, Sterba, J, Styczynski, J, Svintsova, O, Synyuta, A, Szczepanski, T, Szczucinski, P, Szmyd, B, Tasso Cereceda, M, Teliuk, A, Tomanek, I, Topping, P, Torrent, M, Trelinska, J, Troyanovska, O, Trubnikova, E, Tsurkan, L, Tsymbalyuk-Voloshyn, I, Urasinski, T, Urbanek-Dadela, A, Vasilieva, N, Vasilyeva, A, Verdu-Amoros, J, Vilcu-Bajurean, N, Vinitsky, L, Volpe, G, Vorobel, O, Wachowiak, J, Wasiak, M, Wiedower, L, Wuenschel, L, Wysocki, M, Yurieva, M, Zagurska, A, Zakharenko, S, Zakharenko, A, Zapotochna, K, Zawitkowska, J, Agulnik A., Kizyma R., Salek M., Wlodarski M. W., Pogorelyy M., Oszer A., Yakimkova T., Nogovitsyna Y., Dutkiewicz M., Dalle J. -H., Dirksen U., Eggert A., Fernandez-Teijeiro A., Greiner J., Kraal K., Mueller A., Sramkova L., Zecca M., Wise P. H., Mlynarski W., Avula M., Adyrov M. V., Berlanga P., Blackwood C. A., Bouffet E., Czauderna P. S., de Koning L. A., dos Reis Farinha N. J., Foster W. B., Graetz D. E., Gupta S., Holter W., Hough R. E., Kliuchkivska K., Kolenova A., Kolodrubiec J., Moreira D. C., Mukkada S. T., Mykychak I., Raciborska A., Salman Z. S., Sopilnyak A., Tyupa S., Vinitsky A., Wobst N. M., Miller B. A., Rasul S. S., Rodriguez-Galindo C., Alanbousi I., Alexander S. W., Apel A., Bal W. A., Balwierz W. A., Basset-Salom L., Bastardo Blanco D., Bauer K. J., Bayazitov I. T., Bhakta N. H., Bien E. I., Bieniek K. A., Blair S. J., Bodak K. I., Bordeianu I. M., Braganca J. M., Bucurenci M. S., Budny E. B., Budzyn A., Bumgardner C. C., Burditt R. N., Burnside Clapp V. G., Bykov V., Canete A., Carnelli M., Cela E., Cepowska Z. P., Chaber R., Cherner-Drieux A., Chubata M., Clough H. M., Czernicka - Siwecka J., Czyzewski K., Dashchakovska O., Dembowska-Baginska B. M., Derwich K., Dommett R., Dorosh O., Drabko K. A., Dragomir M. D., Dworzak M., Dyma S., Earl J. D., English M. W., Evseev D. A., Farren B. S., Fedyk N., Ferneza S., Fox Irwin L. E., Galazkowski R. M., Ganieva G., Garanzha V., Gelman M. S., Godzinski J. K., Goeres A. F., Golban R., Griksaitis M. J., Hampel M. A., Hastings S. G., Heenen D. L., Hill M. C., Holiuk I., Hutnik L. M., Irga-Jaworska N., Istomin O., Janczar S. L., Kacharian A., Kalwak K., Karolczyk G. M., Karpenko N. M., Katsubo H., Kaznowska B. J., Kentsis A., Ketteler P., Kienesberger A., Kiselev R., Kizyma Z., Klymniuk H., Kostiuk Y., Kowalik T., Kozlova O., Kozubenko V., Kramar T., Krawczuk-Rybak M., Kulemzina I., Kurkowska P., Kuzyk A. S., Ladenstein R. L., Laguna P. J., Lassaletta A., Lehmberg K., Leontieva O., Liashenko S., Loizou L. G., Lucchetta S. A., Lupo M. W., Lysytsia L., Lysytsia O., Machnik K. A., Mainland J. A., Matczak K. E., Matysiak M. J., Mayeur P., Minervina A. A., Mishkova V., Mizia-Malarz A. J., Morales La Madrid A., Moreno L., Moskvin V. P., Muszynska-Roslan K. M., Nelson A. J., Ociepa T., Oltolini S., Onipko N., Pappas A., Patel A. B., Patrahau A., Pauley J. L., Pavlenko Y., Pavlovych A., Peregud-Pogorzelski J., Perek-Polnik M., Perez V., Perez-Martinez A., Pikman Y., Pitozzi G., Portugal R. G., Posternak V. V., Prete A., Pritchard-Jones K., Radaelli A., Reeves T., Reinhardt D., Reshetnyak A. V., Rider A. J., Rizzari C., Rizzi D., Rodriguez Hermosillo K. G., Ronenko O., Rostowska A. O., Rudko L., Sakaan F. M., Sakhar N., Savva N. N., Scaccaglia D., Schaeffer E. H., Schneider C. U., Scobie N., Semeniuk O., Shevchyk R., Shuler A. I., Shvets S., Skoczen S. P., Smeal W. J., Sokolowski I., Sonkin A. A., Stepanjuk A. I., Spota A., Sterba J., Styczynski J., Svintsova O., Synyuta A. V., Szczepanski T., Szczucinski P. K., Szmyd B. M., Tasso Cereceda M., Teliuk A., Tomanek I., Topping P., Torrent M., Trelinska J., Troyanovska O., Trubnikova E., Tsurkan L. G., Tsymbalyuk-Voloshyn I., Urasinski T. F., Urbanek-Dadela A., Vasilieva N., Vasilyeva A., Verdu-Amoros J., Vilcu-Bajurean N., Vinitsky L., Volpe G., Vorobel O., Wachowiak J. T., Wasiak M. S., Wiedower L. A., Wuenschel L. I., Wysocki M. S., Yurieva M., Zagurska A., Zakharenko S. S., Zakharenko A. V., Zapotochna K., Zawitkowska J. E., Agulnik, A, Kizyma, R, Salek, M, Wlodarski, M, Pogorelyy, M, Oszer, A, Yakimkova, T, Nogovitsyna, Y, Dutkiewicz, M, Dalle, J, Dirksen, U, Eggert, A, Fernandez-Teijeiro, A, Greiner, J, Kraal, K, Mueller, A, Sramkova, L, Zecca, M, Wise, P, Mlynarski, W, Avula, M, Adyrov, M, Berlanga, P, Blackwood, C, Bouffet, E, Czauderna, P, de Koning, L, dos Reis Farinha, N, Foster, W, Graetz, D, Gupta, S, Holter, W, Hough, R, Kliuchkivska, K, Kolenova, A, Kolodrubiec, J, Moreira, D, Mukkada, S, Mykychak, I, Raciborska, A, Salman, Z, Sopilnyak, A, Tyupa, S, Vinitsky, A, Wobst, N, Miller, B, Rasul, S, Rodriguez-Galindo, C, Alanbousi, I, Alexander, S, Apel, A, Bal, W, Balwierz, W, Basset-Salom, L, Bastardo Blanco, D, Bauer, K, Bayazitov, I, Bhakta, N, Bien, E, Bieniek, K, Blair, S, Bodak, K, Bordeianu, I, Braganca, J, Bucurenci, M, Budny, E, Budzyn, A, Bumgardner, C, Burditt, R, Burnside Clapp, V, Bykov, V, Canete, A, Carnelli, M, Cela, E, Cepowska, Z, Chaber, R, Cherner-Drieux, A, Chubata, M, Clough, H, Czernicka - Siwecka, J, Czyzewski, K, Dashchakovska, O, Dembowska-Baginska, B, Derwich, K, Dommett, R, Dorosh, O, Drabko, K, Dragomir, M, Dworzak, M, Dyma, S, Earl, J, English, M, Evseev, D, Farren, B, Fedyk, N, Ferneza, S, Fox Irwin, L, Galazkowski, R, Ganieva, G, Garanzha, V, Gelman, M, Godzinski, J, Goeres, A, Golban, R, Griksaitis, M, Hampel, M, Hastings, S, Heenen, D, Hill, M, Holiuk, I, Hutnik, L, Irga-Jaworska, N, Istomin, O, Janczar, S, Kacharian, A, Kalwak, K, Karolczyk, G, Karpenko, N, Katsubo, H, Kaznowska, B, Kentsis, A, Ketteler, P, Kienesberger, A, Kiselev, R, Kizyma, Z, Klymniuk, H, Kostiuk, Y, Kowalik, T, Kozlova, O, Kozubenko, V, Kramar, T, Krawczuk-Rybak, M, Kulemzina, I, Kurkowska, P, Kuzyk, A, Ladenstein, R, Laguna, P, Lassaletta, A, Lehmberg, K, Leontieva, O, Liashenko, S, Loizou, L, Lucchetta, S, Lupo, M, Lysytsia, L, Lysytsia, O, Machnik, K, Mainland, J, Matczak, K, Matysiak, M, Mayeur, P, Minervina, A, Mishkova, V, Mizia-Malarz, A, Morales La Madrid, A, Moreno, L, Moskvin, V, Muszynska-Roslan, K, Nelson, A, Ociepa, T, Oltolini, S, Onipko, N, Pappas, A, Patel, A, Patrahau, A, Pauley, J, Pavlenko, Y, Pavlovych, A, Peregud-Pogorzelski, J, Perek-Polnik, M, Perez, V, Perez-Martinez, A, Pikman, Y, Pitozzi, G, Portugal, R, Posternak, V, Prete, A, Pritchard-Jones, K, Radaelli, A, Reeves, T, Reinhardt, D, Reshetnyak, A, Rider, A, Rizzari, C, Rizzi, D, Rodriguez Hermosillo, K, Ronenko, O, Rostowska, A, Rudko, L, Sakaan, F, Sakhar, N, Savva, N, Scaccaglia, D, Schaeffer, E, Schneider, C, Scobie, N, Semeniuk, O, Shevchyk, R, Shuler, A, Shvets, S, Skoczen, S, Smeal, W, Sokolowski, I, Sonkin, A, Stepanjuk, A, Spota, A, Sterba, J, Styczynski, J, Svintsova, O, Synyuta, A, Szczepanski, T, Szczucinski, P, Szmyd, B, Tasso Cereceda, M, Teliuk, A, Tomanek, I, Topping, P, Torrent, M, Trelinska, J, Troyanovska, O, Trubnikova, E, Tsurkan, L, Tsymbalyuk-Voloshyn, I, Urasinski, T, Urbanek-Dadela, A, Vasilieva, N, Vasilyeva, A, Verdu-Amoros, J, Vilcu-Bajurean, N, Vinitsky, L, Volpe, G, Vorobel, O, Wachowiak, J, Wasiak, M, Wiedower, L, Wuenschel, L, Wysocki, M, Yurieva, M, Zagurska, A, Zakharenko, S, Zakharenko, A, Zapotochna, K, Zawitkowska, J, Agulnik A., Kizyma R., Salek M., Wlodarski M. W., Pogorelyy M., Oszer A., Yakimkova T., Nogovitsyna Y., Dutkiewicz M., Dalle J. -H., Dirksen U., Eggert A., Fernandez-Teijeiro A., Greiner J., Kraal K., Mueller A., Sramkova L., Zecca M., Wise P. H., Mlynarski W., Avula M., Adyrov M. V., Berlanga P., Blackwood C. A., Bouffet E., Czauderna P. S., de Koning L. A., dos Reis Farinha N. J., Foster W. B., Graetz D. E., Gupta S., Holter W., Hough R. E., Kliuchkivska K., Kolenova A., Kolodrubiec J., Moreira D. C., Mukkada S. T., Mykychak I., Raciborska A., Salman Z. S., Sopilnyak A., Tyupa S., Vinitsky A., Wobst N. M., Miller B. A., Rasul S. S., Rodriguez-Galindo C., Alanbousi I., Alexander S. W., Apel A., Bal W. A., Balwierz W. A., Basset-Salom L., Bastardo Blanco D., Bauer K. J., Bayazitov I. T., Bhakta N. H., Bien E. I., Bieniek K. A., Blair S. J., Bodak K. I., Bordeianu I. M., Braganca J. M., Bucurenci M. S., Budny E. B., Budzyn A., Bumgardner C. C., Burditt R. N., Burnside Clapp V. G., Bykov V., Canete A., Carnelli M., Cela E., Cepowska Z. P., Chaber R., Cherner-Drieux A., Chubata M., Clough H. M., Czernicka - Siwecka J., Czyzewski K., Dashchakovska O., Dembowska-Baginska B. M., Derwich K., Dommett R., Dorosh O., Drabko K. A., Dragomir M. D., Dworzak M., Dyma S., Earl J. D., English M. W., Evseev D. A., Farren B. S., Fedyk N., Ferneza S., Fox Irwin L. E., Galazkowski R. M., Ganieva G., Garanzha V., Gelman M. S., Godzinski J. K., Goeres A. F., Golban R., Griksaitis M. J., Hampel M. A., Hastings S. G., Heenen D. L., Hill M. C., Holiuk I., Hutnik L. M., Irga-Jaworska N., Istomin O., Janczar S. L., Kacharian A., Kalwak K., Karolczyk G. M., Karpenko N. M., Katsubo H., Kaznowska B. J., Kentsis A., Ketteler P., Kienesberger A., Kiselev R., Kizyma Z., Klymniuk H., Kostiuk Y., Kowalik T., Kozlova O., Kozubenko V., Kramar T., Krawczuk-Rybak M., Kulemzina I., Kurkowska P., Kuzyk A. S., Ladenstein R. L., Laguna P. J., Lassaletta A., Lehmberg K., Leontieva O., Liashenko S., Loizou L. G., Lucchetta S. A., Lupo M. W., Lysytsia L., Lysytsia O., Machnik K. A., Mainland J. A., Matczak K. E., Matysiak M. J., Mayeur P., Minervina A. A., Mishkova V., Mizia-Malarz A. J., Morales La Madrid A., Moreno L., Moskvin V. P., Muszynska-Roslan K. M., Nelson A. J., Ociepa T., Oltolini S., Onipko N., Pappas A., Patel A. B., Patrahau A., Pauley J. L., Pavlenko Y., Pavlovych A., Peregud-Pogorzelski J., Perek-Polnik M., Perez V., Perez-Martinez A., Pikman Y., Pitozzi G., Portugal R. G., Posternak V. V., Prete A., Pritchard-Jones K., Radaelli A., Reeves T., Reinhardt D., Reshetnyak A. V., Rider A. J., Rizzari C., Rizzi D., Rodriguez Hermosillo K. G., Ronenko O., Rostowska A. O., Rudko L., Sakaan F. M., Sakhar N., Savva N. N., Scaccaglia D., Schaeffer E. H., Schneider C. U., Scobie N., Semeniuk O., Shevchyk R., Shuler A. I., Shvets S., Skoczen S. P., Smeal W. J., Sokolowski I., Sonkin A. A., Stepanjuk A. I., Spota A., Sterba J., Styczynski J., Svintsova O., Synyuta A. V., Szczepanski T., Szczucinski P. K., Szmyd B. M., Tasso Cereceda M., Teliuk A., Tomanek I., Topping P., Torrent M., Trelinska J., Troyanovska O., Trubnikova E., Tsurkan L. G., Tsymbalyuk-Voloshyn I., Urasinski T. F., Urbanek-Dadela A., Vasilieva N., Vasilyeva A., Verdu-Amoros J., Vilcu-Bajurean N., Vinitsky L., Volpe G., Vorobel O., Wachowiak J. T., Wasiak M. S., Wiedower L. A., Wuenschel L. I., Wysocki M. S., Yurieva M., Zagurska A., Zakharenko S. S., Zakharenko A. V., Zapotochna K., and Zawitkowska J. E.

Published
2022

11. GreenFeed and sniffer standard operating procedure (SOP) in dairy and beef cattle

Author

Benzoni, L., Berry, D., Dressler, E., Hegarty, R., Koning, L., McDonnell, Clara, McNaughton, L., Ritchie, G., Finocchiaro, R., van Breukelen, A.E., Garcia-Rodriguez, A., Gonzalez Recio, O., Richardson, C., Villumsen, T.M., Gredler-Grandl, B., Benzoni, L., Berry, D., Dressler, E., Hegarty, R., Koning, L., McDonnell, Clara, McNaughton, L., Ritchie, G., Finocchiaro, R., van Breukelen, A.E., Garcia-Rodriguez, A., Gonzalez Recio, O., Richardson, C., Villumsen, T.M., and Gredler-Grandl, B.

Abstract

Enteric methane emissions from ruminants are a major contributor to atmospheric greenhouse gas accumulation. Accurate measurement of methane production in ruminants is crucial to not only develop reliable national greenhouse gas emission inventories, but also evaluate mitigation strategies for methane emissions. Measuring actual enteric emissions in livestock is complex, expensive and time consuming. Many different research and industry bodies globally are investigating the feasibility and accuracy of a range of different techniques for recording enteric methane emissions. Amongst the techniques available, GreenFeed (C-Lock Inc. Rapid City, SD, USA) and sniffer systems are the most common. The objective of this study is to describe standard operating procedures for GreenFeed and sniffers in measuring enteric methane emissions in dairy and beef cattle leveraging the expertise and experience of those operating the equipment in a range of different settings; the procedures were share and discussed through meetings organized by the ICAR Feed and Gas Working Group. Standard operating procedure items of interest include, amongst others, animal training protocols and adaption period length, number of animals per machine, equipment troubleshooting and upgrades. Experiences collected will be part of the ICAR Methane Emission Recording Guidelines update.

Published
2023

14. Heritability and genetic correlations of enteric methane emissions of dairy cows measured by sniffers and GreenFeed

Author

van Breukelen, A.E., Aldridge, M.N., Veerkamp, R.F., Koning, L., Sebek, L.B., de Haas, Y., van Breukelen, A.E., Aldridge, M.N., Veerkamp, R.F., Koning, L., Sebek, L.B., and de Haas, Y.

Abstract

Before methane (CH4 ) emission can be mitigated with animal breeding, breath measurements have to be recorded on a large number of cows. Our aim was to estimate heritabilities for, and a genetic correlation between, CH4 recorded by GreenFeed and sniffers. Repeated records were available for CH4 production(g/cow/day) by GreenFeed and for CH4 concentration (ppm) by sniffers. The data included 24,284 GreenFeed daily means from 822 cows, 172,948 sniffer daily means from 1,800 cows, and 1,787 daily means from both devices on the same day from 75 cows. Additionally, records were averaged per week. The datasets were analyzed using bivariate animal models. The results show that CH4 emissions recorded by either device has a moderate heritability (0.18-0.37). Furthermore, the genetic correlation between weekly mean CH4 recorded by GreenFeed or by sniffers was high (0.77). This suggest that the measurements can be used in the same genetic evaluations.

Published
2022

15. Effect of grazing method on grass quality change during a 24- hour period

Author

Holshof, G., Klootwijk, C.W., Koning, L., Klop, A., Holshof, G., Klootwijk, C.W., Koning, L., and Klop, A.

Abstract

Changes in grass quality during day and night can be relevant for both research and practice. In research a representative sample of the provided grass is essential for reliable results, and for practice it can affect management decisions. In a zero-grazing system, grass is brought to the barn two to three times a day and afterwards fed in small portions which might lead to a decay of grass quality. In a pasture, fresh grass quality can change during the day and night under the influence of sunlight and selection by the cows.In a grazing trial on the Dairy Campus, it was examined how grass quality was affected over time. In the zero-grazing system, a sample was taken on 7 occasions during a 24-h period to assess the quality. In the 24-h grazing system, fresh grass samples were taken from the same plot around 8 am and 6 pm. The samples were analysed on feed quality. It appeared that mowing fresh grass twice a day and providing it in small portions over the day did not result in a significant change in feed quality. During grazing, it was found that in the evening the sugar content was higher and the crude protein content lower. There was no significant difference in the other components. These results show that time of sampling fresh grass in pasture needs to be taken into account in grazing research.

Published
2022

19. Online computer or therapist-guided cognitive behavioral therapy in university students with anxiety and/or depression: study protocol of a randomised controlled trial

Author

Klein, Anke, primary, Wolters, N E, additional, Bol, E J M, additional, Koelen, J, additional, de Koning, L, additional, Roetink, S S M, additional, van Blom, J J, additional, Pronk, T, additional, van der Heijde, Claudia, additional, Salemink, Elske, additional, Bolinski, Felix, additional, Riper, Heleen, additional, Karyotaki, Eirini, additional, Cuijpers, Pim, additional, Schneider, S, additional, Rapee, Ronald M, additional, Vonk, Peter, additional, and Wiers, Reinout W, additional

Published
2021
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21. Praktijkimplementatie CH4 en NH3 reductie via voerspoor - praktijkrapport 2020 : Voerstrategieën om de methaan- en ammoniakemissie te reduceren in de melkveehouderij

Author

Koning, L., Evers, A.G., and Šebek, L.B.

Subjects
Animal Nutrition, Emissie & Mestverwaarding, Life Science, Emissions & Manure Valorisation, Diervoeding
Abstract

This report describes the first prototyping round of the implementation of feeding strategies to reduce methane emissions on five dairy farms. The project goal is to reduce both methane and ammonia emission with 30% compared to the reference year. Feeding strategies were developed, implemented and tested on efficiency on five commercial dairy farms. According to model calculations, 5-15% reduction was realized on all farms. On two farms this reduction was measured as well. To achieve a higher reduction potential changes in roughage quality are probably necessary. An integrated approach is essential to accomplish the project goals. One of the challenges is to make objective decisions when strategies are conflicting with other goals. The first prototyping round showed that it is possible to reduce methane emission up to 20% short-term. This study will continue to search for feeding strategies with long-term, annual reduction potentials of both methane and ammonia. Deze praktijkrapportage beschrijft een eerste prototyping ronde van het implementeren van voerstrategieën op vijf melkveebedrijven. De implementatie heeft als doel om uiteindelijk een reductie van 30% van zowel methaan als ammoniak te realiseren ten opzichte van het referentiejaar. Voerstrategieën zijn ontwikkeld, geïmplementeerd en onderzocht op effectiviteit en werkbaarheid op vijf melkveebedrijven. Volgens modelberekeningen werd er 5 tot 15% reductie gerealiseerd, op twee bedrijven werd deze reductie ook terug gemeten. Voor het realiseren van meer reductie zal het sturen van de ruwvoerkwaliteit naar een lagere emissiefactor vermoedelijk de grootste effecten gaan opleveren. Belangrijk hierin is de integrale aanpak en de grootste uitdaging is het kunnen maken van een objectieve afweging bij tegenstrijdige effecten op verschillende belangen. Deze eerste prototyping ronde liet zien dat tot 20% methaanreductie gedurende een korte periode werd gerealiseerd. Opschalen naar een jaarrond emissiereductie zal verdere ontwikkeling van de bedrijfsvoering vragen, wat in kaart wordt gebracht via het prototyping model.

Published
2021

23. Online computer or therapist-guided cognitive behavioral therapy in university students with anxiety and/or depression: study protocol of a randomised controlled trial

Author

Klein, A., Wolters, N.E., Bol, E.J.M., Koelen, J., de Koning, L., Roetink, S.S.M., van Blom, J.J., Pronk, T., van der Heijde, C., Salemink, E., Bolinski, F., Riper, H., Karyotaki, E., Cuijpers, P., Schneider, S, Rapee, R.M., Vonk, P., Wiers, R.W., Klein, A., Wolters, N.E., Bol, E.J.M., Koelen, J., de Koning, L., Roetink, S.S.M., van Blom, J.J., Pronk, T., van der Heijde, C., Salemink, E., Bolinski, F., Riper, H., Karyotaki, E., Cuijpers, P., Schneider, S, Rapee, R.M., Vonk, P., and Wiers, R.W.

Abstract

Introduction Emerging adulthood is a phase in life that is associated with an increased risk to develop a variety of mental health disorders including anxiety and depression. However, less than 25% of university students receive professional help for their mental health reports. Internet-based cognitive behavioural therapy (iCBT) may entail useful interventions in a format that is attractive for university students. The aim of this study protocol is to test the effectiveness of a therapist-guided versus a computer-guided transdiagnostic iCBT programme with a main focus on anxiety and depression. Methods and analysis University students with anxiety and/or depressive symptoms will be randomised to a (1) 7-week iCBT programme (excluding booster session) with therapist feedback, (2) the identical iCBT programme with computer feedback only or (3) care as usual. Participants in the care as usual condition are informed and referred to conventional care services and encouraged to seek the help they need. Primary outcome variables are self-reported levels of anxiety as measured with the General Anxiety Disorder-7 and self-reported levels of depression as measured with the Patient Health Questionnaire-9. Secondary outcomes include treatment adherence, client satisfaction, medical service use, substance use, quality of life and academic achievement. Assessments will take place at baseline (t1), midtreatment (t2), post-treatment (t3), at 6 months (t4) and 12 months (t5) postbaseline. Social anxiety and perfectionism are included as potentially important predictors of treatment outcome. Power calculations are based on a 3 (group) × 3 (measurement: pretreatment, midtreatment and post-treatment) interaction, resulting in an aimed sample of 276 participants. Data will be analysed based on intention-to-treat and per protocol samples using mixed linear models.

Published
2021

24. Online computer or therapist-guided cognitive behavioral therapy in university students with anxiety and/or depression: study protocol of a randomised controlled trial

Author

Experimental psychopathology, Leerstoel Engelhard, Klein, A., Wolters, N.E., Bol, E.J.M., Koelen, J., de Koning, L., Roetink, S.S.M., van Blom, J.J., Pronk, T., van der Heijde, C., Salemink, E., Bolinski, F., Riper, H., Karyotaki, E., Cuijpers, P., Schneider, S, Rapee, R.M., Vonk, P., Wiers, R.W., Experimental psychopathology, Leerstoel Engelhard, Klein, A., Wolters, N.E., Bol, E.J.M., Koelen, J., de Koning, L., Roetink, S.S.M., van Blom, J.J., Pronk, T., van der Heijde, C., Salemink, E., Bolinski, F., Riper, H., Karyotaki, E., Cuijpers, P., Schneider, S, Rapee, R.M., Vonk, P., and Wiers, R.W.

Published
2021

29. En toen.... was er een nieuwe canon

Author

de Koning, L., van Boxtel, C., and Domain specific Learning (RICDE, FMG)

Abstract

De Canon is vernieuwd, op 22 juni 2020 presenteerde de commissie ‘Herijking Canon van Nederland’ de vernieuwde Canon. Er zijn tien nieuwe vensters bijgekomen, vier vensters zijn gewijzigd en er zijn tien vensters verdwenen. Na zo’n herziening staan actualiteitenprogramma’s en kranten vol met experts en wetenschappers die hun reactie geven, positief en negatief. Louise Fresco miste aandacht voor natuurwetenschappen in de nieuwe canon, universitair docenten misten de Europese context en docenten geschiedenis in het voortgezet onderwijs maakten zich druk om de beperkte tijd voor het vak geschiedenis op het VMBO. Wat hebben onze leerlingen aan deze Canon?

Published
2020

30. Ondermijnende criminaliteit samen aanpakken

Author

Kerstholt, J., Vos, P., and Koning, L. de

Subjects
HOI - Human Behaviour & Organisational Innovations, Ketensamenwerking, Criminaliteit, Human & Operational Modelling, Politie
Abstract

Een succesvolle aanpak van ondermijnende criminaliteit vraagt om betrokkenheid van meer partijen dan alleen de politie en het OM. TNO onderzoekt met het Ondermijningslab hoe je die integrale samenwerking tussen verschillende ketenpartners zo effectief mogelijk kan lopen verlopen.

Published
2020

31. Genetic markers and phosphoprotein forms of beta-catenin p?-Cat552 and p?-Cat675 are prognostic biomarkers of cervical cancer

Author

Scholl, SM, Beal, J, Koning, L, Girard, E, Popovic, M, de la Rochefordière, A, Lecuru, F, Fourchotte, V, Ngo, C, Floquet, A, Berns, Els, Kenter, G, Gestraud, P, von der Leyen, H, Lecerf, C, Puard, V, Roman, SR, Latouche, A, Kereszt, A, Balint, B, Rouzier, R, Kamal, M, Scholl, SM, Beal, J, Koning, L, Girard, E, Popovic, M, de la Rochefordière, A, Lecuru, F, Fourchotte, V, Ngo, C, Floquet, A, Berns, Els, Kenter, G, Gestraud, P, von der Leyen, H, Lecerf, C, Puard, V, Roman, SR, Latouche, A, Kereszt, A, Balint, B, Rouzier, R, and Kamal, M

Published
2020

32. Jaarrondmeting enterisch methaan startpunt voor mogelijke reducties

Author

Koning, L. and Sebek, L.B.

Subjects
Animal Nutrition, Diervoeding
Abstract

Begin oktober zijn op de Koeien & Kansen-bedrijven de jaarrondmetingen van enterisch methaan afgerond. Dit geeft een praktijkbeeld van de methaanemissie uit de bek van de melkkoeien op Nederlandse bedrijven en is de start van onderzoek naar relaties tussen de methaanemissie en dier- en bedrijfskenmerken. Op basis daarvan kunnen we ideeën ontwikkelen voor emissiereducties die we in een volgende fase van Koeien & Kansen kunnen toetsten en implementeren.

Published
2019

33. Werken aan de veerkracht van burger

Author

Steen, M.G.D., Koning, L. de, and Kerstholt, J.

Subjects
HOI - Human Behaviour & Organisational Innovations, Human & Operational Modelling, Burgers, Calamiteiten, Crisic
Abstract

Burgers zijn niet altijd even goed voorbereid op incidenten, zoals een overstroming of bosbrand. Een serie Community Workshops vanuit het Europese onderzoeksproject SOURCE hielp de veerkracht van burgers te vergroten. De inzichten uit deze workshops zijn ook relevant voor andere crisissituaties, zoals ondermijning en radicalisering.Burgers zijn niet altijd even goed voorbereid op incidenten, zoals een overstroming of bosbrand. Een serie Community Workshops vanuit het Europese onderzoeksproject SOURCE hielp de veerkracht van burgers te vergroten. De inzichten uit deze workshops zijn ook relevant voor andere crisissituaties, zoals ondermijning en radicalisering.

Published
2019

34. Impact of β-catenin phosphorylation patterns on tumour control/progression in a prospective cervical cancer study (RAIDs)

Author

Scholl, S., primary, Latouche, A., additional, De Koning, L., additional, Popovic, M., additional, de la Rochefordière, A., additional, Berns, E., additional, Gestraud, P., additional, Girard, E., additional, Lecerf, C., additional, von der Leyen, H., additional, Roman Roman, S., additional, Rouzier, R., additional, Kamal, M., additional, and Consortium, R., additional

Published
2019
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38. Molecular profiles as a function of treatment response/progression free survival in a prospective cervical cancer study (RAIDs)

Author

Scholl, S., primary, De Koning, L., additional, Popovic, M., additional, Anne, D.L.R., additional, Floquet, A., additional, Berns, E., additional, Kenter, G., additional, Kereszt, A., additional, Girard, E., additional, von der Leyen, H., additional, Dureau, S., additional, Fourchotte, V., additional, Rouzier, R., additional, Kamal, M., additional, and Consortium, R., additional

Published
2018
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40. Motivated cognition in negotiation

Author

Koning, L., van Dijk, E., Olekalns, M., Adair, W.L., and Sociale Psychologie (Psychologie, FMG)

Subjects
Interdependence, Surprise, Negotiation, media_common.quotation_subject, Psychological research, Political science, Scale (social sciences), Constructive, Outcome (game theory), Social psychology, Social relation, Law and economics, media_common
Abstract

As people live side by side in ever-growing societies, conflicts of interests seem almost inevitable. Conflicts may appear at a large scale involving many people (for example, a conflict between nations) or at a small scale involving just two people (for example, two partners bickering over the daily chores). Inherent to all conflicts is their potential to escalate. Conflicts between nations can escalate into wars and conflicts between partners can turn into fights. Such escalations are often costly to all parties involved. A war, for example, may result in a large loss of lives. It is clear that escalation of a conflict is something one wants to avoid. Negotiations offer a more constructive way to solve conflicts. Given the potential benefits, it should be no surprise that negotiations have been a focal topic in economic and psychological research. Negotiating can be described as a social interaction in which two or more parties in conflict seek a better outcome through joint action than they could realize independently (Lax and Sebenius, 1986). It is important to note that this definition stresses both a conflict of interests and interdependency.

Published
2013
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41. A tool to quickly increase knowledge for effective coordination in crises

Author

Koning, L. de, Dongen, C.J.G. van, Thönissen, F.H., Essens, P.J.M.D., and Vries, T. de

Subjects
Integrated understanding, Damage detection, Collaboration, Team knowledge, HOI - Human Behaviour & Organisational Innovations, Information management, Coordination, Preparation, Information systems, Human resource management, Human & Operational Modelling, ELSS - Earth, Life and Social Sciences, Coordination reactions
Abstract

In complex crises, coordination between organizations is challenging. Knowledge needed to coordinate, like responsibilities, capabilities and interdependencies between tasks are often not known or not communicated systematically. As a result, coordination develops gradually and causes confusion. In this paper we describe an approach and tool called 'Profiler', that focuses on quickly increasing knowledge and understanding about the participating organizations while preparing for, or at the beginning of a crisis. Profiler was evaluated during an exercise of 1 Civil Military Coordination Battalion (1CIMICbat). Teams consisting of functional specialists performed a damage and needs assessments after a flooding. The results show that participants that used Profiler increased their knowledge and integrated understanding, when this was initially lacking. Further, participants with improved knowledge and integrated understanding, coordinated more within and between teams, when they perceived to be interdependent. Our results point in the direction that coordination effectiveness and efficiency may be improved with our approach. et al.; Information Systems for Crisis Response and Management (ISCRAM); Iterop; KIMOCE; Safe Cluster; Vinovalie - Les Vignerons Dovalie

Published
2017

42. Human Factors in Cyber Incident Response : Needs, collaboration and The Reporter

Author

Huis in 't Veld, M.A.A., Kleij, R. van der, Kleinhuis, G., Koning, L. de, Kort, J., Meiler, P.P., Schendel, J.A. van, Schultz, S., and Young, H.J.

Subjects
HOI - Human Behaviour & Organisational Innovations, Human & Operational Modelling, ELSS - Earth, Life and Social Sciences
Abstract

1 Introduction 3 2 Needs assessment 6 2.1 Results 7 2.2 Discussion 14 3 Process of cyber incident management 16 3.1 Architecture 17 3.2 Organisational view 18 3.3 Role view 19 3.4 Process view 19 3.5 Connecting processes to decision support: Profiles 20 4 Collaborative Sensemaking 22 4.1 Approach 22 4.2 Needs of CSIRTs 22 4.3 Collaborative sensemaking 23 4.4 Collaborative sensemaking within CSIRTS 27 4.5 Supporting Collaborative sensemaking 27 5 The Reporter 30 5.1 Specifying the user and organizational requirements 31 5.2 Producing design solutions 32 5.3 Evaluating the design 34 6 Field experiences 35 6.1 Interviews 35 6.2 Exercise 36 6.3 Conclusions 38 7 Final workshop 39 7.1 Structure of the final workshop 39 7.2 Feedback on the Reporter and its different parts 39 7.3 Follow-up with workshop participants 42 8 Conclusions and future directions 43 9 References 44 Appendices A Research questions

Published
2017

43. Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation

Author

BULLÓ BONET, MÒNICA, Pérez-Martínez, P., Mikhailidis, DP., Athyros, VG., Couture, P., Covas, MI., de Koning, L., Delgado-Lista, J., Díaz-López, A., Drevon, CA., Estruch, R., Esposito, K., Fitó, M., Garaulet, M., Giugliano, D., García-Ríos, A., Katsiki, N., Kolovou, G., Lamarche, B., Maiorino, MI., Mena-Sánchez, G., Muñoz-Garach, A., Nikolic, D., Ordovás, JM., Pérez-Jiménez, F., Rizzo, M., SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili

Subjects
Ciències de la salut, 0029-6643, Health sciences, METABOLISME TRASTORNS, DIETOTERÀPIA, Dietary patterns, Lifestyle, Ciencias de la salud, metabolic syndrome
Abstract

The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the available scientific evidence on the associations between lifestyle changes and MetS and its components is reviewed to derive recommendations for MetS prevention and management. Weight loss through an energy-restricted diet together with increased energy expenditure through physical activity contribute to the prevention and treatment of MetS. A Mediterranean-type diet, with or without energy restriction, is an effective treatment component. This dietary pattern should be built upon an increased intake of unsaturated fat, primarily from olive oil, and emphasize the consumption of legumes, cereals (whole grains), fruits, vegetables, nuts, fish, and low-fat dairy products, as well as moderate consumption of alcohol. Other dietary patterns (Dietary Approaches to Stop Hypertension, new Nordic, and vegetarian diets) have also been proposed as alternatives for preventing MetS. Quitting smoking and reducing intake of sugar-sweetened beverages and meat and meat products are mandatory. Nevertheless, there are inconsistencies and gaps in the evidence, and additional research is needed to define the most appropriate therapies for MetS. In conclusion, a healthy lifestyle is critical to prevent or delay the onset of MetS in susceptible individuals and to prevent cardiovascular disease and type 2 diabetes in those with existing MetS. The recommendations provided in this article should help patients and clinicians understand and implement the most effective approaches for lifestyle change to prevent MetS and improve cardiometabolic health.

Published
2017

44. Staat van netcentrisch samenwerken 2017 : Een eerste beeld van de netcentrische samenwerking tussen veiligheidsregio's, GHOR'en en waterschappen

Author

Koning, L. de, Brink, P.E. van den, Treurniet, W., and Suitela, V.

Subjects
Historisch materiaal TNO, HOI - Human Behaviour & Organisational Innovations NO - Networked Organisations, Human & Operational Modelling, ELSS - Earth, Life and Social Sciences
Abstract

Steeds meer organisaties in het veiligheidsdomein hanteren in het geval van grootschalig optreden de netcentrische werkwijze. De vijfentwintig veiligheidsregio’s passen deze werkwijze al een aantal jaren toe en, in opdracht van de Regiegroep Netcentrisch Werken, heeft TNO sinds de implementatie van de werkwijze ieder jaar de 'staat van netcentrisch werken' vastgesteld. Hieruit was af te leiden dat de veiligheidsregio’s de afgelopen jaren een grote ontwikkeling hebben doorgemaakt op het gebied van netcentrisch werken. Ook diverse crisispartners, zoals waterschappen, zien inmiddels de meerwaarde van netcentrisch werken in en implementeren deze werkwijze in hun eigen organisatie. Gezien de steeds nadrukkelijker focus van het Programma Netcentrisch Werken op de samenwerking met crisispartners heeft de Regiegroep Netcentrisch Werken besloten om in 2017 de focus van 'De staat van netcentrisch werken' te verschuiven naar de netcentrische samenwerking tussen de veiligheidsregio’s en crisispartners. Er is voor gekozen om dit jaar twee typen vitale partners die de netcentrische werkwijze geïmplementeerd hebben of gaan implementeren te betrekken bij de rapportage, namelijk de 22 waterschappen en een selectie van 10 GHOR’en. Doel van het onderzoek is daarmee het verkrijgen van een beeld van de netcentrische samenwerking tussen veiligheidsregio’s, waterschappen en GHOR’en. Het onderzoek richt zich op zowel sterke punten, als ontwikkelpunten en uitdagingen voor de deelnemende partijen en resulteert in algemene aanbevelingen en aanknopingspunten voor alle partijen om de netcentrische samenwerking door te ontwikkelen. In het kader van het onderzoek zijn op diverse plaatsen in het land 'regionale' workshops georganiseerd. Daarbij is ernaar gestreefd alle drie betrokken partijen (veiligheidsregio’s, GHOR’en en waterschappen) uit een bepaald deel van het land bij elkaar te brengen. De bevindingen zijn samen te vatten onder vier onderwerpen: • Vormgeving van de netcentrische samenwerking; • Beeldvorming; • Oordeels- en besluitvorming; • Continu risicobeeld. Samenvatting 2 1 Inleiding 6 1.1 Achtergrond 6 1.2 Vraag- en doelstelling 2017 6 1.3 Leeswijzer 7 2 Aanpak 8 2.1 Organisatie workshops 8 2.2 Opzet workshops 9 2.3 Aanpak analyse resultaten 10 3 Bevindingen netcentrische samenwerking 11 3.1 Vormgeven van de netcentrische samenwerking 11 3.2 Beeldvorming 14 3.3 Oordeelsvorming en besluitvorming 18 3.4 Continu risicobeeld 20 3.5 Overzicht werkvormen 24 4 Conclusie en aanbevelingen 26 4.1 Algemene aanbevelingen 26 4.2 Aanbevelingen inzake het vormgeven van de samenwerking 28 4.3 Aanbevelingen inzake beeldvorming 29 4.4 Aanbevelingen inzake oordeelsvorming en besluitvorming 30 4.5 Aanbevelingen inzake continu risicobeeld 32 4.6 Tot slot 33 5 Referentielijst 34 Bijlage(n) A Overzicht deelnemers workshops B Workshop Materiaal C Afkortingenlijst

Published
2017

45. Biomarkers of tenderness and intramuscular fat in five muscles from French PDO Maine-Anjou: I- Muscle type effect

Author

Picard, Brigitte, Al Jammas, M., Ellies, Marie-Pierre, GAGAOUA, Mohammed, Couvreur, S., Pecot, M., Aminot, G., de Koning, L., Valais, A., Bonnet, Muriel, Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Unité de Recherche sur les Systèmes d’Elevage (URSE), Université Bretagne Loire (UBL), Institut Curie [Paris], and Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)

Subjects
HSPs proteins, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], Meat quality, Muscle proteome, PDO Maine-Anjou cows, Pre-slaughter handling, [SHS]Humanities and Social Sciences
Abstract

International audience; This paper describes the difference in the relative abundance of 20 proteins in five muscles: Longissimus thoracis (LT), Rectus abdominis (RA), Semimembranosus (SM), Semitendinosus (ST) and Triceps brachii (TB) of cattle from the French Maine Anjou Protected Designation of Origin (PDO). These proteins are biomarkers of tenderness and intramuscular fat previously identified by proteomic analysis. The relative abundance of the proteins was evaluated by Reverse Phase Protein Array (RPPA) with specific antibodies. The main results showed a muscle effect on 16 of 20 biomarkers. The RA muscle was significantly different from other muscles by the lower abundance of 6 proteins and the higher abundance of 5 proteins. In the ST muscle, 4 proteins were less abundant and 4 others corresponding to fast glycolytic type, were more abundant. Clustering analysis revealed associations between proteins irrespective of muscle type and others were muscle dependent. The knowledge of these associations are important to understand the mechanism involved in these meat properties.

Published
2017
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48. Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation

Author

Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, BULLÓ BONET, MÒNICA; Pérez-Martínez, P.; Mikhailidis, DP.; Athyros, VG.; Couture, P.; Covas, MI.; de Koning, L.; Delgado-Lista, J.; Díaz-López, A.; Drevon, CA.; Estruch, R.; Esposito, K.; Fitó, M.; Garaulet, M.; Giugliano, D.; García-Ríos, A.; Katsiki, N.; Kolovou, G.; Lamarche, B.; Maiorino, MI.; Mena-Sánchez, G.; Muñoz-Garach, A.; Nikolic, D.; Ordovás, JM.; Pérez-Jiménez, F.; Rizzo, M.; SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and BULLÓ BONET, MÒNICA; Pérez-Martínez, P.; Mikhailidis, DP.; Athyros, VG.; Couture, P.; Covas, MI.; de Koning, L.; Delgado-Lista, J.; Díaz-López, A.; Drevon, CA.; Estruch, R.; Esposito, K.; Fitó, M.; Garaulet, M.; Giugliano, D.; García-Ríos, A.; Katsiki, N.; Kolovou, G.; Lamarche, B.; Maiorino, MI.; Mena-Sánchez, G.; Muñoz-Garach, A.; Nikolic, D.; Ordovás, JM.; Pérez-Jiménez, F.; Rizzo, M.; SALAS SALVADÓ, JORGE

Abstract

The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the available scientific evidence on the associations between lifestyle changes and MetS and its components is reviewed to derive recommendations for MetS prevention and management. Weight loss through an energy-restricted diet together with increased energy expenditure through physical activity contribute to the prevention and treatment of MetS. A Mediterranean-type diet, with or without energy restriction, is an effective treatment component. This dietary pattern should be built upon an increased intake of unsaturated fat, primarily from olive oil, and emphasize the consumption of legumes, cereals (whole grains), fruits, vegetables, nuts, fish, and low-fat dairy products, as well as moderate consumption of alcohol. Other dietary patterns (Dietary Approaches to Stop Hypertension, new Nordic, and vegetarian diets) have also been proposed as alternatives for preventing MetS. Quitting smoking and reducing intake of sugar-sweetened beverages and meat and meat products are mandatory. Nevertheless, there are inconsistencies and gaps in the evidence, and additional research is needed to define the most appropriate therapies for MetS. In conclusion, a healthy lifestyle is critical to prevent or delay the onset of MetS in susceptible individuals and to prevent cardiovascular disease and type 2 diabetes in those with existing MetS. The recommendations provided in this article should help patients and clinicians understand and implement the most effective approaches for lifestyle change to prevent MetS and improve cardiometabolic health.

Published
2017

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