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1. Joint density for the local times of continuous-time Markov chains: Extended version

Author

Brydges, D., van der Hofstad, R., and Konig, W.

Subjects
Mathematics - Probability, 60J27, 60J55, 15A75
Abstract

We investigate the local times of a continuous-time Markov chain on an arbitrary discrete state space. For fixed finite range of the Markov chain, we derive an explicit formula for the joint density of all local times on the range, at any fixed time. We use standard tools from the theory of stochastic processes and finite-dimensional complex calculus. We apply this formula in the following directions: (1) we derive large deviation upper estimates for the normalized local times beyond the exponential scale, (2) we derive the upper bound in Varadhan's \chwk{l}emma for any measurable functional of the local times, \ch{and} (3) we derive large deviation upper bounds for continuous-time simple random walk on large subboxes of $\Z^d$ tending to $\Z^d$ as time diverges. We finally discuss the relation of our density formula to the Ray-Knight theorem for continuous-time simple random walk on $\Z$, which is analogous to the well-known Ray-Knight description of Brownian local times. In this extended version, we prove that the Ray-Knight theorem follows from our density formula., Comment: 22 pages

Published
2005

3. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe

Author

Hageman, S., Pennells, L., Ojeda, F., Kaptoge, S., Kuulasmaa, K., Vries, T. de, Xu, Z., Kee, F., Chung, R., Wood, A., McEvoy, J.W., Veronesi, G., Bolton, T., Dendale, P., Ference, B.A., Halle, M., Timmis, A., Vardas, P., Danesh, J., Graham, I., Salomaa, V., Visseren, F., Bacquer, D. de, Blankenberg, S., Dorresteijn, J., Angelantonio, E. di, Achenbach, S., Aleksandrova, K., Amiano, P., Amouyel, P., Andersson, J., Bakker, S.J.L., Costa, R.B.D., Beulens, J.W.J., Blaha, M., Bobak, M., Boer, J.M.A., Bonet, C., Bonnet, F., Boutron-Ruault, M.C., Braaten, T., Brenner, H., Brunner, F., Brunner, E.J., Brunstrom, M., Buring, J., Butterworth, A.S., Capkova, N., Cesana, G., Chrysohoou, C., Colorado-Yohar, S., Cook, N.R., Cooper, C., Dahm, C.C., Davidson, K., Dennison, E., Castelnuovo, A. di, Donfrancesco, C., Dorr, M., Dorynska, A., Eliasson, M., Engstrom, G., Ferrari, P., Ferrario, M., Ford, I., Fu, M., Gansevoort, R.T., Giampaoli, S., Gillum, R.F., Camara, A.G. de la, Grassi, G., Hansson, P.O., Huculeci, R., Hveem, K., Iacoviello, L., Ikram, M.K., Jorgensen, T., Joseph, B., Jousilahti, P., Jukema, J.W., Kaaks, R., Katzke, V., Kavousi, M., Kiechl, S., Klotsche, J., Konig, W., Kronmal, R.A., Kubinova, R., Kucharska-Newton, A., Lall, K., Lehmann, N., Leistner, D., Linneberg, A., Pablos, D.L., Lorenz, T., Lu, W.T., Luksiene, D., Lyngbakken, M., Magnussen, C., Malyutina, S., Ibanez, A.M., Masala, G., Mathiesen, E.B., Matsushita, K., Meade, T.W., Melander, O., Meyer, H.E., Moons, K.G.M., Moreno-Iribas, C., Muller, D., Munzel, T., Nikitin, Y., Nordestgaard, B.G., Omland, T., Onland, C., Overvad, K., Packard, C., Pajak, A., Palmieri, L., Panagiotakos, D., Panico, S., Perez-Cornago, A., Peters, A., Pietila, A., Pikhart, H., Psaty, B.M., Quarti-Trevano, F., Garcia, J.R.Q., Riboli, E., Ridker, P.M., Rodriguez, B., Rodriguez-Barranco, M., Rosengren, A., Roussel, R., Sacerdote, C., Sans, S., Sattar, N., Schiborn, C., Schmidt, B., Schottker, B., Schulze, M., Schwartz, J.E., Selmer, R.M., Shea, S., Shipley, M.J., Sieri, S., Soderberg, S., Sofat, R., Tamosiunas, A., Thorand, B., Tillmann, T., Tjonneland, A., Tong, T.Y.N., Trichopoulou, A., Tumino, R., Tunstall-Pedoe, H., Tybjaerg-Hansen, A., Tzoulaki, J., Heijden, A. van der, Schouw, Y.T. van der, Verschuren, W.M.M., Volzke, H., Waldeyer, C., Wareham, N.J., Weiderpass, E., Weidinger, F., Wild, P., Willeit, J., Willeit, P., Wilsgaard, T., Woodward, M., Zeller, T., Zhang, D.D., Zhou, B., SCORE2 Working Grp, ESC Cardiovasc Risk Collaboration, collaboration, SCORE2 working group and ESC Cardiovascular risk, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Epidemiology, Neurology, Achenbach, S, Aleksandrova, K, Amiano, P, San Sebastian, D, Amouyel, P, Andersson, J, Bakker, S, Da Providencia Costa, R, Beulens, J, Blaha, M, Bobak, M, Boer, J, Bonet, C, Bonnet, F, Boutron-Ruault, M, Braaten, T, Brenner, H, Brunner, F, Brunner, E, Brunström, M, Buring, J, Butterworth, A, Capkova, N, Cesana, G, Chrysohoou, C, Colorado-Yohar, S, Cook, N, Cooper, C, Dahm, C, Davidson, K, Dennison, E, Di Castelnuovo, A, Donfrancesco, C, Dörr, M, Doryńska, A, Eliasson, M, Engström, G, Ferrari, P, Ferrario, M, Ford, I, Fu, M, Gansevoort, R, Giampaoli, S, Gillum, R, Gómez de la Cámara, A, Grassi, G, Hansson, P, Huculeci, R, Hveem, K, Iacoviello, L, Ikram, M, Jørgensen, T, Joseph, B, Jousilahti, P, Wouter Jukema, J, Kaaks, R, Katzke, V, Kavousi, M, Kiechl, S, Klotsche, J, König, W, Kronmal, R, Kubinova, R, Kucharska-Newton, A, Läll, K, Lehmann, N, Leistner, D, Linneberg, A, Pablos, D, Lorenz, T, Lu, W, Luksiene, D, Lyngbakken, M, Magnussen, C, Malyutina, S, Ibañez, A, Masala, G, Mathiesen, E, Matsushita, K, Meade, T, Melander, O, Meyer, H, Moons, K, Moreno-Iribas, C, Muller, D, Münzel, T, Nikitin, Y, Nordestgaard, B, Omland, T, Onland, C, Overvad, K, Packard, C, Pająk, A, Palmieri, L, Panagiotakos, D, Panico, S, Perez-Cornago, A, Peters, A, Pietilä, A, Pikhart, H, Psaty, B, Quarti-Trevano, F, Garcia, J, Riboli, E, Ridker, P, Rodriguez, B, Rodriguez-Barranco, M, Rosengren, A, Roussel, R, Sacerdote, C, S, S, Sattar, N, Schiborn, C, Schmidt, B, Schöttker, B, Schulze, M, Schwartz, J, Selmer, R, Shea, S, Shipley, M, Sieri, S, Söderberg, S, Sofat, R, Tamosiunas, A, Thorand, B, Tillmann, T, Tjønneland, A, Tong, T, Trichopoulou, A, Tumino, R, Tunstall-Pedoe, H, Tybjaerg-Hansen, A, Tzoulaki, J, van der Heijden, A, van der Schouw, Y, Verschuren, W, Völzke, H, Waldeyer, C, Wareham, N, Weiderpass, E, Weidinger, F, Wild, P, Willeit, J, Willeit, P, Wilsgaard, T, Woodward, M, Zeller, T, Zhang, D, Zhou, B, and Apollo - University of Cambridge Repository

Subjects
Male, Cardiology, RATIONALE, Blood Pressure, Disease, 030204 cardiovascular system & hematology, PROFILE, ACUTE CORONARY EVENTS, VALIDATION, Europe/epidemiology, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, DESIGN, Clinical Research, Risk Factors, Diabetes mellitus, medicine, PARTICIPANTS, Humans, 030212 general & internal medicine, Risk factor, Aged, Primary prevention, business.industry, 10-year CVD risk, Incidence (epidemiology), Cardiovascular Diseases/epidemiology, Risk Prediction, Cardiovascular Disease, Primary Prevention, 10-year Cvd Risk, External validation, PRIMARY-CARE, Middle Aged, medicine.disease, Cardiovascular disease, Risk prediction, 3. Good health, Europe, Prediction algorithms, Blood pressure, Cardiovascular Diseases, Smoking status, Female, Cardiology and Cardiovascular Medicine, business, Algorithms, Demography
Abstract

Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe.Methods and results We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking status, systolic blood pressure, and total- and HDL-cholesterol. We defined four risk regions in Europe according to country-specific CVD mortality, recalibrating models to each region using expected incidences and risk factor distributions. Region-specific incidence was estimated using CVD mortality and incidence data on 10 776 466 individuals. For external validation, we analysed data from 25 additional cohorts in 15 European countries (1 133 181 individuals, 43 492 CVD events). After applying the derived risk prediction models to external validation cohorts, C-indices ranged from 0.67 (0.65-0.68) to 0.81 (0.76-0.86). Predicted CVD risk varied several-fold across European regions. For example, the estimated 10-year CVD risk for a 50-year-old smoker, with a systolic blood pressure of 140 mmHg, total cholesterol of 5.5 mmol/L, and HDL-cholesterol of 1.3 mmol/L, ranged from 5.9% for men in low- risk countries to 14.0% for men in very high-risk countries, and from 4.2% for women in low-risk countries to 13.7% for women in very high-risk countries.Conclusion SCORE2-a new algorithm derived, calibrated, and validated to predict 10-year risk of first-onset CVD in European populations-enhances the identification of individuals at higher risk of developing CVD across Europe. Acknowledgements We thank investigators and participants of the several studies that contributed data to the Emerging Risk Factors Collaboration (ERFC). This research has been conducted using the UK Biobank Resource under Application Number 26865. Data from the Clinical Practice Research Datalink (CPRD) were obtained under licence from the UK Medicines and Healthcare products Regulatory Agency (protocol 162RMn2). CPRD uses data provided by patients and collected by the NHS as part of their care and support. We thank all EPIC participants and staff for their contribution to the study, the laboratory teams at the Medical Research Council Epidemiology Unit for sample management and Cambridge Genomic Services for genotyping, Sarah Spackman for data management and the team at the EPIC-CVD Coordinating Centre for study co-ordination and administration. Funding The ERFC co-ordinating centre was underpinned by programme grants from the British Heart Foundation (SP/09/002; RG/13/13/30194; RG/18/13/33946), BHF Centre of Research Excellence (RE/18/1/34212), the UK Medical Research Council (MR/L003120/1), and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (BRC1215-20014), with project-specific support received from the UK NIHR [*], British United Provident Association UK Foundation and an unrestricted educational grant from GlaxoSmithKline. A variety of funding sources have supported recruitment, follow-up, and laboratory measurements in the studies contributing data to the ERFC, which are listed on the ERFC website (www.phpc.cam.ac.uk/ceu/erfc/list-of-studies). *The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and Wellcome. The MORGAM Project has received funding from EU projects MORGAM (Biomed BMH4-CT98-3183), GenomEUtwin (FP5, QLG2-CT-2002-01254), ENGAGE (FP7, HEALTH-F4-2007-201413),CHANCES (FP7, HEALTH-F3-2010-242244), BiomarCaRE (FP7,HEALTH-F2-2011-278913), euCanSHare (Horizon 2020, No. 825903) and AFFECT-EU (Horizon 2020, No. 847770); and Medical Research Council, London (G0601463, No. 80983: Biomarkers in the MORGAM Populations). This has supported central coordination, workshops and part of the activities of the MORGAM Data Centre, the MORGAM Laboratories and the MORGAM Participating Centres EPIC-CVD was funded by the European Research Council (268834), and the European Commission Framework Programme 7 (HEALTH-F2-2012-279233). This work was supported by the Estonian Research Council grant PUTs (PRG687, PUT1660, PUT1665, PRG184), by European Union through the European Regional Development Fund project no. MOBERA5 (Norface Network project no 462.16.107), by the Green ICT programme under Norway Grants 2014 – 2021 (grant number EU53928), by the European Union through Horizon 2020 grant no. 810645 and through the European Regional Development Fund (Project No. 2014-2020.4.01.16-0125) and by the PRECISE4Q consortium. PRECISE4Q project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant agreement 777107. This work was partly funded through the CoMorMent project. CoMorMent has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant agreement 847776. The KORA study was initiated and financed by the Helmholtz Zentrum Mu¨nchen—German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. The KORA study was supported by a research grant from the Virtual Institute of Diabetes Research (Helmholtz Zentrum Mu¨nchen), the Clinical Cooperation Group Diabetes between Ludwig-Maximilians-Universita¨t Mu¨nchen and Helmholtz Zentrum Mu¨nchen, and by the German Diabetes Center (DDZ). The HAPIEE project, Institute, was supported by grants from the Wellcome Trust (064947/Z/01/Z; WT081081) and US National Institute on Aging (1R01 and AG23522). The co-ordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Ge´ne´rale de l’Education Nationale, Institut National de la Sante´ et de la Recherche Me´dicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch 2448 SCORE2 working group and ESC Cardiovascular Risk Collaboration Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucı´a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Ska˚ne and Va¨sterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom)

Published
2021
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4. Influenza B Pneumonia with Staphylococcus aureus Superinfection Associated with Parvovirus B19 and Concomitant Agranulocytosis

Author

Krell, S., Adams, I., Arnold, U., Kalinski, T., Aumann, V., Konig, W., and Konig, B.

Subjects
Pneumonia in children -- Case studies, Health
Abstract

Byline: S. Krell (1), I. Adams (2), U. Arnold (1), T. Kalinski (3), V. Aumann (4), W. Konig (1), B. Konig (1) Abstract: Abstract. An 11-year-old patient with anamnestic fever for 3 days and signs of upper respiratory tract infection underwent fulminant Staphylococcus aureus pneumonia with concomitant agranulocytosis. From autopsia influenza B virus and parvovirus B19 were detected by nucleic acid amplification technique (NAT). Specific IgG but no IgM points to preexisting parvovirus B19 infection. Whether in this case agranulocytosis can be interpreted as early manifestation of reactivated parvovirus B19 infection is under discussion. Therefore, parvovirus B19 could have provoked a foudroyant course of influenza B pneumonia which was superinfected with S. aureus. Author Affiliation: (1) Institute of Medical Microbiology, Medical Faculty, Otto von Guericke University Magdeburg, Leipziger Str. 44, D-39120, Magdeburg, Germany (2) Dept. of Pediatrics, Division of General Pediatrics and Neonatology, Medical Faculty, Otto von Guericke University Magdeburg, Germany (3) Dept. of Pathology and Forensic Medicine, Institute of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Germany (4) Dept. of Pediatrics, Division of Pediatric Hematology and Oncology, Medical Faculty, Otto von Guericke University Magdeburg, Germany Article History: Received Date: 27/05/2002 Accepted Date: 19/12/2002

Published
2003

5. Prolonged Application of Closed In-Line Suction Catheters Increases Microbial Colonization of the Lower Respiratory Tract and Bacterial Growth on Catheter Surface

Author

Freytag, C. C., Thies, F. L., Konig, W., and Welte, T.

Subjects
Catheters -- Risk factors, Catheters -- Safety and security measures, Infection -- Prevention, Health
Abstract

Byline: C. C. Freytag (1), F. L. Thies (1), W. Konig (1), T. Welte (2) Abstract: Background: Microorganisms become attracted to polymer surfaces for a number of reasons including positive charge of biomaterial or concentration of nutrients on the biomaterial surface. Many bacteria aditionally possess specific receptors for the interaction with extracellular host protein components that adhere on the biomaterial surface. Several authors suggest that application of closed in-line polypropylene suction catheters (CISC) in intubated patients for more than 24 h is safe and can reduce the costs associated with mechanical ventilation. Therefore, we evaluated the possible role of prolonged application of CISC to cause enhanced colonization of both the biomaterial and the lower respiratory tract. Materials and Methods: The prospective, randomized study included 23 mechanically ventilated patients. The CISC tips, adjacent segments and tracheobronchial aspirates of each patient were examined for microbial growth. Results: Application for 72 h significantly enhanced the microbial growth on the CISC tips and on the adjacent catheter segment. Usage for 3 days led to a significant increase in colonization in the lower respiratory tract. Conclusion: Normal saline instillation in conjunction with endotracheal suctioning may lead to a dispersion of microorganisms into the lower respiratory tract. More effective self-cleaning mechanisms are necessary to decontaminate the CISC surface after suctioning. Author Affiliation: (1) Institute of Medical Microbiology, Otto-von-Guericke University, Leipzigerstr. 44, D-39120 Magdeburg, Germany. ccfreytag@t-online.de, DE (2) Division of Pulmology and Critical Care, Otto-von-Guericke University, Magdeburg, Germany, DE Article note: Received: April 23, 2002 * Revision accepted: October 5, 2002 C. C. Freytag (corresponding author)

Published
2003

6. Rapid Ribosequencing -- an Effective Diagnostic Tool for Detecting Microbial Infection

Author

Trotha, R., Hanck, T., Konig, W., and Konig, B.

Subjects
Bacterial infections -- Diagnosis, Bacterial infections -- Care and treatment, Bacteria, Pathogenic -- Identification and classification, Bacteria, Pathogenic -- Research, Health
Abstract

Byline: R. Trotha (1), T. Hanck (2), W. Konig (1), B. Konig (1) Keywords: Key Words Rapid ribosequencing; Microorganisms; Tropheryma whippelii; Blastobacter denitrificans Abstract: Background: Rapid and reliable identification of microorganisms is a prerequisite for the diagnosis and subsequent treatment of infectious diseases. The identification of pathogenic bacteria is traditionally based on their isolation from clinical samples and propagation on culture medium in the routine laboratory. However, despite clinical signs of infection, culture of the pathogenic agent often fails. This may be due to a low number of microorganisms, prior antibiotic treatment, nonculturable microorganisms or specific culture requirements for presently unknown pathogens. Amplification and sequencing of the entire prokaryotic 16S-rRNA is time consuming, labor intensive and expensive. Materials and Methods: We describe here a procedure for the identification of a wide range of known and unknown clinically relevant microorganisms by sequencing a small, but highly informative region of the prokaryotic 16S-rRNA gene. This rapid ribosequencing method was evaluated with various reference strains and with clinical samples including eye anterior chamber fluid, cerebrospinal fluid (CSF) and blood cultures. Results: All sequences obtained from the reference strains corresponded to the sequences in databases. We correlated severe eye infection with the isolation of Pseudomonas putida, neurological disorder with Tropheryma whippelii and disseminated visceral abscesses in a child with Blastobacter denitrificans. Conclusion: We consider the rapid ribosequencing method as a promising new tool for the analysis of infectious agents in primarily sterile body fluids where conventional culturing of microorganisms fails. Author Affiliation: (1) Institute for Medical Microbiology, Otto-von-Guericke University Magdeburg, Leipzigerstr. 44, D-39120 Magdeburg, Germany Phone: (+49/391) 67-13353, Fax: -190023, e-mail: brigitte.koenig@medizin.uni-magdeburg.de, DE (2) Center for Biochemistry and Molecular Biology, Otto-von-Guericke University Magdeburg, D-39120 Magdeburg, Germany, DE Article note: Received: June 14, 2000 * Revision accepted: October 13, 2000

Published
2001

8. Arachidonic Acid Induces DNA-Fragmentation in Human Polymorphonuclear Neutrophil Granulocytes

Author

Koller, M., Wachtler, P., David, A., Muhr, G., and Konig, W.

Subjects
Arachidonic acid -- Physiological aspects, DNA damage -- Causes of, Neutrophils -- Physiological aspects, Cell research, Health
Abstract

Byline: M. Koller (1), P. Wachtler (2), A. David (1), G. Muhr (1), W. Konig (3) Abstract: We analyzed DNA-fragmentation in human polymorphonuclear neutrophil granulocytes (PMNs) from healthy donors after addition of exogenous arachidonic acid (AA) and eicosapentaenoic acid (EPA) by flow cytometry (propidium iodide staining of DNA and DNA strand break detection). The PMNs were incubated from 30 min up to 48 hours in RPMI 1640 which was supplemented with different concentrations of AA or EPA (5--40 uM). In contrast to EPA the addition of AA led to a significant increase in apoptosis up to 67.8% compared to the RPMI-control whereas the addition of EPA led to an inhibition of DNA-fragmentation. When the cells were incubated with MK 886 (1uM, inhibitor of leukotriene biosynthesis) an increase in DNA-fragmentation (up to 63.3%) was observed. Conversely, in the presence of indomethacin (1uM, inhibitor of prostanoid synthesis) an inhibition in DNA-fragmentation (up to 60.9%) occurred. Furthermore, preincubation of PMNs with pentoxifylline (1mM, phosphodiesterase inhibitor) reduced AA-stimulated DNA-fragmentation up to 43.4%. These data provide evidence for the involvement of AA and distinct AA metabolites in the regulation of apoptosis in human PMNs. Author Affiliation: (1) Department of Surgery, Surgical Research, BG Klinik Bergmannsheil, D-44789, Bochum, Germany (2) Med. Clinic I, Marienhospital, Herne, Germany (3) Inst. Med. Microbiology, Magdeburg, Germany Article History: Registration Date: 06/09/2004

Published
1997

11. Laser technology rejuvenates hot machining; laser-assisted turning of ceramics contributes to the expansion of the range of methods used to machine ceramic materials

Author

Konig, W. and Zaboklicki, A.K.

Subjects
Ceramic industry -- Innovations, Lasers -- Usage, Construction and materials industries, Engineering and manufacturing industries
Abstract

Hot machining technology is enjoying a renaissance thanks to progress in laser techniques. The flame-, friction- and resistance-heating media were used in this field at the beginning of the 20th [...]

Published
1993

15. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Author

Gorski, M, van der Most, PJ, Teumer, A, Chu, AY, Li, M, Mijatovic, V, Nolte, IM, Cocca, M, Taliun, D, Gomez, F, Li, Y, Tayo, B, Tin, A, Feitosa, MF, Aspelund, T, Attia, J, Biffar, R, Bochud, M, Boerwinkle, E, Borecki, I, Bottinger, EP, Chen, MH, Chouraki, V, Ciullo, M, Coresh, J, Cornelis, MC, Curhan, GC, d'Adamo, AP, Dehghan, A, Dengler, L, Ding, JZ (Jing Zhong), Eiriksdottir, G, Endlich, K, Enroth, S, Esko, T, Franco Duran, OH, Gasparini, P, Gieger, C, Girotto, G, Gottesman, O, Gudnason, V, Gyllensten, U, Hancock, S J, Harris, TB, Helmer, C, Hollerer, S, Hofer, E, Hofman, Bert, Holliday, EG, Homuth, G, Hu, FB, Huth, C, Hutri-Kahonen, N, Hwang, SJ, Imboden, M, Johansson, A, Kahonen, M, Konig, W, Kramer, H, Kramer, BK, Kumar, A, Kutalik, Z, Lambert, JC, Launer, LJ, Lehtimaki, T, Borst, Marja, Navis, G, Swertz, M, Liu, YM, Lohman, K, Loos, RJF, Lu, YC, Lyytikainen, LP, McEvoy, M A, Meisinger, C, Meitinger, T, Metspalu, A, Metzger, M, Mihailov, E, Mitchell, P, Nauck, M, Oldehinkel, AJ, Olden, M, Penninx, B, Pistis, G, Pramstaller, PP, Probst-Hensch, N, Raitakari, OT, Rettig, R, Ridker, PM, Rivadeneira, Fernando, Robino, A, Rosas, SE, Ruderfer, D, Ruggiero, D, Saba, Y, Sala, C, Schmidt, H, Schmidt, R, Scott, RJ, Sedaghat, Sanaz, Smith, AV, Sorice, R, Stengel, B, Stracke, S, Strauch, K, Toniolo, D, Uitterlinden, André, Ulivi, S, Viikari, JS, Volker, U, Vollenweider, P, Volzke, H, Vuckovic, D, Waldenberger, M, Wang, JJ, Yang, QO, Chasman, DI, Tromp, G, Snieder, H, Heid, IM, Fox, CS, Kottgen, A, Pattaro, C, Boger, CA, Fuchsberger, C, Gorski, M, van der Most, PJ, Teumer, A, Chu, AY, Li, M, Mijatovic, V, Nolte, IM, Cocca, M, Taliun, D, Gomez, F, Li, Y, Tayo, B, Tin, A, Feitosa, MF, Aspelund, T, Attia, J, Biffar, R, Bochud, M, Boerwinkle, E, Borecki, I, Bottinger, EP, Chen, MH, Chouraki, V, Ciullo, M, Coresh, J, Cornelis, MC, Curhan, GC, d'Adamo, AP, Dehghan, A, Dengler, L, Ding, JZ (Jing Zhong), Eiriksdottir, G, Endlich, K, Enroth, S, Esko, T, Franco Duran, OH, Gasparini, P, Gieger, C, Girotto, G, Gottesman, O, Gudnason, V, Gyllensten, U, Hancock, S J, Harris, TB, Helmer, C, Hollerer, S, Hofer, E, Hofman, Bert, Holliday, EG, Homuth, G, Hu, FB, Huth, C, Hutri-Kahonen, N, Hwang, SJ, Imboden, M, Johansson, A, Kahonen, M, Konig, W, Kramer, H, Kramer, BK, Kumar, A, Kutalik, Z, Lambert, JC, Launer, LJ, Lehtimaki, T, Borst, Marja, Navis, G, Swertz, M, Liu, YM, Lohman, K, Loos, RJF, Lu, YC, Lyytikainen, LP, McEvoy, M A, Meisinger, C, Meitinger, T, Metspalu, A, Metzger, M, Mihailov, E, Mitchell, P, Nauck, M, Oldehinkel, AJ, Olden, M, Penninx, B, Pistis, G, Pramstaller, PP, Probst-Hensch, N, Raitakari, OT, Rettig, R, Ridker, PM, Rivadeneira, Fernando, Robino, A, Rosas, SE, Ruderfer, D, Ruggiero, D, Saba, Y, Sala, C, Schmidt, H, Schmidt, R, Scott, RJ, Sedaghat, Sanaz, Smith, AV, Sorice, R, Stengel, B, Stracke, S, Strauch, K, Toniolo, D, Uitterlinden, André, Ulivi, S, Viikari, JS, Volker, U, Vollenweider, P, Volzke, H, Vuckovic, D, Waldenberger, M, Wang, JJ, Yang, QO, Chasman, DI, Tromp, G, Snieder, H, Heid, IM, Fox, CS, Kottgen, A, Pattaro, C, Boger, CA, and Fuchsberger, C

Published
2017

16. Antibiotic Susceptibility Testing of H. pylori after Failed Eradication Therapy: Culture of H. pylori from a Gastric String is a reliable Alternative to Endoscopic Biopsy

Author

Leodolter, A., Wolle, K., Peitz, U., Konig, W, and Malfertheiner, P.

Subjects
Research, Gastrointestinal diseases -- Research
Abstract

A. Leodolter [1] K. Wolle, [1] U. Peitz [1] W Konig [2] P. Malfertheiner [1] [16/05] [*] Antibiotic Susceptibility Testing of H. pylori after Failed Eradication Therapy: Culture of H. [...]

Published
2001

17. Cytokine and Chemotaxin Receptor Expression from Gastric Carcinoma Cells is Dependent on Virulence Factors of H. pylori

Author

Wolle, K., Leodolter, A., Konig, W., and Malfertheiner, P.

Subjects
Research, Gastrointestinal diseases -- Research, Helicobacter pylori -- Research, Helicobacter infections -- Research
Abstract

K. Wolle [1] A. Leodolter [1] W. Konig [2] P. Malfertheiner [1] [4/16] Cytokine and Chemotaxin Receptor Expression from Gastric Carcinoma Cells is Dependent on Virulence Factors of H. pylori [...]

Published
2001

18. Analysis of Primary Resistance to Clarithromycin in H. pylori

Author

Wolle, K., Leodolter, A., Konig, W., and Malfertheiner, P.

Subjects
Drug therapy, Physiological aspects, Research, Microbial drug resistance -- Research -- Drug therapy, Clarithromycin -- Physiological aspects -- Research, Helicobacter pylori -- Research -- Physiological aspects, Helicobacter infections -- Drug therapy -- Research, Drug resistance in microorganisms -- Research -- Drug therapy
Abstract

K. Wolle [1] A. Leodolter [1] W. Konig [2] P. Malfertheiner [1] [1/17] Analysis of Primary Resistance to Clarithromycin in H. pylori Background: Several macrolides have been used in H. [...]

Published
2001

22. Central Limit Theorem for a Weakly Interacting Random Polymer

Author

Hofstad, R. van der, Hollander, F. den, and Konig, W.

Subjects
Domb-Joyce model, Stochastics and operational research, Knight's theorem for local times of simple random walk, central limit theorem, Wiskunde en Informatica, spectral analysis, time change and scaling
Abstract

The Domb-Joyce model in one dimension is a transformed path measure for simple random walk on Zin which an n-step path gets a penalty e for every self-intersection. Here n is the strength of repellence, which may depend on n. We prove a central limit theorem for the end-to-end distance of the path in the case where n ! 0 and n 3 2 n ! 1 as n ! 1. It turns out that the mean grows like b 1 3 n n and the standard deviation like cpn, where b and c are constants that can be identied in terms of a Sturm-Liouville problem. The asymptotic mean shows an interpolation between ballistic behavior (n ) and diusive behavior (n = n ). Strikingly, the asymptotic standard deviation is independent of n. Our result is closely related to the central limit theorem for the Edwards model (the continuous space-time analogue of the Domb-Joyce model based on Brownian motion on R), which is proved in a separate paper.

Published
1997

23. Directions in object-oriented systems development research

Author

van Hillegersberg, J, Kumar, K (Kuldeep), Welke, RJ, Dias Coelho, J., Jelassi, T., Konig, W., Krcmar, H., O'Callaghan, R., Saaksjarvi, M., Department of Technology and Operations Management, and Rotterdam School of Management

Published
1996

27. Far infrared characterization of samarium doped single crystal PbTe

Author

Nikolić, Pantelija M., Konig, W., Luković, Danijela, Savić, Slavica M., Vujatović, Stevan S., Radulović, Katarina, Blagojević, Vladimir, Nikolić, Pantelija M., Konig, W., Luković, Danijela, Savić, Slavica M., Vujatović, Stevan S., Radulović, Katarina, and Blagojević, Vladimir

Abstract

Single crystal samples of lead telluride doped with samarium were produced using the Bridgman method. Far infrared reflectivity spectra in the temperature range 10 K - 300 K are presented and numerically analyzed using a fitting procedure based on a modified plasmon phonon interaction model. The optical parameters were determined and three local modes of samarium were observed at about 167 cm-1, 227 cm-1 and 486 cm-1.

Published
2004

28. (-)-germacrene D receptor neurones in three species of heliothine moths : structure-activity relationships

Author

Stranden, M., Liblikas, I., Konig, W. A., Almaas, T. J., Borg-Karlson, Anna-Karin, Mustaparta, H., Stranden, M., Liblikas, I., Konig, W. A., Almaas, T. J., Borg-Karlson, Anna-Karin, and Mustaparta, H.

Abstract

Specificity of olfactory receptor neurones plays an important role in food and host preferences of a species, and may have become conserved or changed in the evolution of polyphagy and oligophagy. We have identified a major type of plant odour receptor neurones responding to the sesquiterpene germacrene D in three species of heliothine moths, the polyphagous Heliothis virescens and Helicoverpa armigera and the oligophagous Helicoverpa assulta. The neurones respond with high sensitivity and selectivity to (-)-germacrene D, as demonstrated by screening via gas chromatography with numerous mixtures of plant volatiles. Germacrene D was present in both host and non-host plants, but only in half of the tested species. The specificity of the neurones was similar in the three species, as shown by the 'secondary' responses to a few other sesquiterpenes. The effect of (-)-germacrene D was about ten times stronger than that of the (+)-enantiomer, which again was about ten times stronger than that of (-)-alpha-ylangene. Weaker effects were obtained for (+)-beta-ylangene, (+)-alpha-copaene, beta-copaene and two unidentified sesquiterpenes. The structure-activity relationship shows that the important properties of (-)-germacrene D in activating the neurones are the ten-membered ring system and the three double bonds acting as electron-rich centres, in addition to the direction of the isopropyl-group responsible for the different effects of the germacrene D enantiomers., QC 20100525

Published
2003
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34. Far-infrared study of impurity local modes in gallium-doped PbTe

Author

Romčević, Nebojša Ž., Romčević, Maja J., Khokhlov, DR, Belogorokhov, AI, Ivanchik, II, Konig, W, Romčević, Nebojša Ž., Romčević, Maja J., Khokhlov, DR, Belogorokhov, AI, Ivanchik, II, and Konig, W

Abstract

We present far-infrared reflection spectra and results of galvanomagnetic measurements of PbTe single crystals doped with gallium between 10 and 300 K. The analysis of the far-infrared reflection spectra was made by a fitting procedure based on the model of coupled oscillators. Together with the strong plasmon-phonon coupling we obtain three local modes of gallium at about 122, 166 and 192 cm(-1). The position of these modes depends of impurity center charge, and their intensity depends of temperature and of gallium concentration. Persistent photoconductivity effect was registered in the sample with 0.4 at.% Ga by galvanomagnetic and far-infrared measurements. (C) 1999 Elsevier Science B.V. All rights reserved.

Published
1999

39. Central limit theorem for the Edwards model

Author

Hofstad, R. van der, Hollander, F. den, Konig, W., Hofstad, R. van der, Hollander, F. den, and Konig, W.

Abstract

Contains fulltext : 29205.pdf (publisher's version ) (Open Access)

Published
1997

43. Penetration Depth of Tl2Ba2Ca2Cu3Oy and Tl0:58Pb0:4Sr1:6Ba0:4Ca2Cu3Oy Bulk Superconductors.

Author

ZALECKI, R., WOCH, W. M., KOÝODZIEJCZYK, A., KONIG, W. T., and GRITZNER, G.

Subjects
MEISSNER effect, SUPERCONDUCTORS, SUPERCONDUCTIVITY, ELECTRONIC materials, TRANSITION temperature
Abstract

The penetration depths of bulk Tl2Ba2Ca2Cu3Oy and Tl0:58Pb0:4Sr1:6Ba0:4Ca2Cu3Oy superconductors with the critical temperatures 112 K and 114 K, respectively, were determined from the AC susceptibility measurements. When the samples are in the Meissner state, the dispersive components of AC susceptibility as well as their temperature dependences reflect the changes of the penetration depths at various temperatures. In these bulk ceramic superconductors the penetration depths are of the order of few μm and they are comparable to the grains sizes in the ceramics. [ABSTRACT FROM AUTHOR]

Published
2014
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