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Your search keyword '"Kong, Xiao-Ling"' showing total 19 results
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19 results on '"Kong, Xiao-Ling"'

2. The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer

Author

Liu, Tong, Yang, Sheng, Cheng, Yan-ping, Kong, Xiao-ling, Du, Dan-dan, Wang, Xian, Bai, Yun-fei, Yin, Li-hong, Pu, Yue-pu, and Liang, Ge-yu

Subjects
YTHDF1, gastric cancer, RNA methylation, diagnostic signature, m6A, Original Research
Abstract

Purpose Gastric cancer (GC) is aggressive cancer with a high mortality rate worldwide. N6-methyladenosine (m6A) RNA methylation is related to tumorigenesis, which is dynamically regulated by m6A modulators (“writer,” “eraser,” and “reader”). We conducted a comprehensive analysis of the m6A genes of GC patients in TCGA datasets to identify the potential diagnostic biomarkers. Materials and Methods We analyzed the expression profile of m6A genes in the TCGA cohort and constructed a diagnostic-m6A-score (DMS) by the LASSO-logistic model. In addition, by consensus cluster analysis, we identified two different subgroups of GC risk individuals by the expression profile of m6A modulators, revealing that YTHDF1’s expression variation profile in GC diagnosis. We also performed RT-qPCR and WB verification in 17 pairs of GC specimens and paired adjacent non-tumor tissues and GC cell lines, and verified the expression trend of YTHDF1 in five GEO GC datasets. YTHDF1 expression and clinical features of GC patients were assessed by the UALCAN. Results The DMS with high specificity and sensitivity (AUC = 0.986) is proven to distinguish cancer from normal controls better. Moreover, we found that the expression profile variation of YTHDF1 was significantly associated with the high-risk subtype of GC patients. RT-qPCR and Western blot results are consistent with silicon analysis, revealing that YTHDF1’s potential oncogene role in GC tumor. Conclusion In conclusion, we developed the m6A gene-based diagnostic signature for GC and found that YTHDF1 was significantly correlated with the high-risk subtype of GC patients, suggesting that YTHDF1 might be a potential target in GC early diagnosis.

Published
2020

7. Numerical investigation of a silicon six-wafer microcombustor under the effect of heat loss through the outer walls

Author

Zhu, Lin, Jen, Tien-Chien, and Kong, Xiao-Ling

Subjects
Combustion chambers -- Thermal properties, Combustion chambers -- Mechanical properties, Combustion chambers -- Composition, Numerical analysis -- Research, Silicon -- Mechanical properties, Silicon -- Thermal properties, Engineering and manufacturing industries, Science and technology
Abstract

In this paper, the influences of low heat transfer condition at the outer walls on the microcombustor are investigated due to the fact that a sufficiently small heat transfer coefficient at the outer wall incurs the upstream burning in the recirculation jacket, results in the high wall temperature, and hence possibly damages the microcombustor. Numerical simulation approaches focused on the microcombustor with the flame burning in the recirculation jacket. Combustion characteristics of the combustor were first analyzed based on 2D computational fluid dynamics (CFD), and then the most dangerous locations on the combustor were predicted by means of the 3D finite element analysis method. The study demonstrates the effectiveness of CFD and stress modeling for the design and improvement of the microcombustors. [DOI: 10.1115/1.4002804]

Published
2010

10. Research and development of the software on computer-aided fixtures designing

Author

Kong Xiao-ling, Zhou Jie, Zhang Hua, Zhao Wenlong, Guo Chen, and Yangyi

Subjects
Engineering drawing, Engineering, business.product_category, Standardization, Process (engineering), business.industry, Software development, Fixture, Machine tool, Development (topology), Software, Systems engineering, Computer-aided, business
Abstract

The design of the machine tool fixture is very common in technical design. The purpose of the present research is to improve the efficiency of fixture design with the help of computer-aided fixture design. Examples of the fixture-design software development based on the AutoCAD platform are introduced. From the perspective of engineers, problems during the process of fixture design are discussed. The standardization of fixture design is also discussed.

Published
2009

17. Progress on Technologies and Facility of Dead Animal Treatment.

Author

HAO Feng-pei, KONG Xiao-ling, and SHANG Bin

Subjects
DEAD animals, ANIMAL culture, TRANSPORTATION of animals, INCINERATION, HYDROLYSIS
Abstract

Biosafety treatment of dead animals is the crucial avenue for non-hazardous and reutilization, to ensure the healthy development of animal husbandry. This paper briefly introduced the dead animal storage, transportation and related laws and regulations. This paper also reviewed the research status, characteristics of the main technologies and facility of dead animal treatment including burial, incineration, alkaline hydrolysis, rendering, composting, biodegradation under high temperature and anaerobic digestion, which might give references for choosing the reasonable technology of dead animal treatment. [ABSTRACT FROM AUTHOR]

Published
2014
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18. A Story of Soil Loss and Soil Degradation on the Loess Plateau In China

Author

Zhong-zi, Kong Xiao-ling, and Tang Keli

Subjects
Hydrology, Sediment yield, Soil loss, Soil retrogression and degradation, Environmental science, Sediment, Soil science, Loess plateau, Soil fertility, China
Abstract

The Loess Plateau lies in the middle reaches of the Huanghe or Yellow River. Grievous soil erosion has caused the Huanghe to transport an average annual sediment load of 1.6 billion tons. Of this, about 400 million tons are deposited in the riverbed of the lower reaches, and the rest, or about 1.2 billion tons, empty into the sea, along with the loss of much fertile soil.

Published
1989

19. [Technology of advanced glycation endproducts fluorescence measurement and precorrection].

Author

Xu LY, Liu Y, Zhang G, Zhu L, Wang YK, Kong XL, and Wu LS

Subjects
Case-Control Studies, Diabetes Mellitus, Fluorescence, Humans, Glycation End Products, Advanced chemistry, Skin chemistry, Spectrum Analysis
Abstract

The necessity to measure advanced glycation endproducts (AGE) was analyzed in the present paper, and the apparatus for measuring skin autofluorescence was also designed making use of the special excitation spectrum and emission spectrum. A portion of tissue at the volar side of the arm of individuals (11 diabetes and 19 control subjects) was illuminated with excitation light, i.e., monochromatic light around 370 nm, and the emission spectrum was detected on the skin of control subjects and diabetic patients respectively. All measurements were performed at room temperature in a semi-dark environment. It can be seen that different sites of an individual could lead to different results, and the color can also affect the results. The technology of fluorescence precorrection was applied in order to get rid of the influence of noise, different site of skin, the color of skin etc. The result indicates that the technology of precorrection is of avail and the repetitiveness is well.

Published
2010

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