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2. Intravenous tirofiban following successful reperfusion in intracranial large artery atherosclerotic stroke: A secondary analysis of a randomized clinical trial.

Author

Huang, Jiacheng, Kong, Weilin, Liu, Chang, Song, Jiaxing, Yang, Jie, Yue, Chengsong, Li, Linyu, Hu, Jinrong, Tian, Yan, Peng, Zhouzhou, Guo, Changwei, Yang, Dahong, Liu, Xiang, Miao, Jian, Zhang, Xiao, Li, Fengli, Saver, Jeffrey, and Zi, Wenjie

Subjects
Humans, Tirofiban, Fibrinolytic Agents, Brain Ischemia, Treatment Outcome, Stroke, Intracranial Hemorrhages, Arteries, Reperfusion
Abstract

OBJECTIVE: This study aimed to investigate whether treatment with adjunct intravenous tirofiban is associated with improved outcomes following successful reperfusion in patients with intracranial atherosclerotic stroke. METHODS: Patients with intracranial large artery atherosclerotic (LAA) stroke and an expanded Treatment in Cerebral Ischemia angiographic score of 2b50 to 3 from the Effect of Intravenous Tirofiban versus Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke (RESCUE BT) trial were included. The primary outcome was the difference in proportion of independent functional outcome (modified Rankin score of 0-2 at 90 days). Safety outcomes included the rates of symptomatic intracranial hemorrhage (sICH) and 90-day mortality. RESULTS: Among the 382 patients with intracranial LAA stroke and successful reperfusion, 175 patients (45.8%) were treated with intravenous tirofiban and 207 (54.2%) with placebo. The proportion of patients with independent functional outcome at 90 days was 54.3% (95 out of 175) with tirofiban and 44.0% (91 out of 207) with placebo (adjusted odds ratio [aOR], 1.58; 95% CI, 1.02-2.44; p = 0.04). Intravenous tirofiban was not significantly associated with an increased risk of sICH (12/175 [6.9%] vs. 11/207 [5.3%]; aOR, 1.41; 95% CI, 0.59-3.34; p = 0.44) or 90-day mortality (21/175 [12.0%] vs. 34/207 [16.4%]; aOR, 0.71; 95% CI, 0.38-1.31; p = 0.27). INTERPRETATION: Among patients with acute intracranial LAA stroke and successful reperfusion following endovascular thrombectomy, adjunct intravenous tirofiban was associated with a higher rate of independent functional outcome, without higher rates of sICH or mortality. Confirmatory randomized trials in these patients are desirable.

Published
2023

10. Effect of Imaging Selection Paradigms on Endovascular Thrombectomy Outcomes in Patients With Acute Ischemic Stroke

Author

Miao, Jian, Sang, Hongfei, Li, Fengli, Saver, Jeffrey L., Lei, Bo, Li, Jinglun, Nogueira, Raul Gomes, Song, Bo, Liu, Shudong, Nguyen, Thanh N., Jin, Zhenglong, Zeng, Hongliang, Wen, Changming, Yuan, Guangxiong, Kong, Weilin, Luo, Weidong, Liu, Shuai, Xie, Dongjing, Huang, Jiacheng, Liu, Chang, Yang, Jie, Hu, Jinrong, Song, Jiaxing, Yue, Chengsong, Li, Linyu, Tian, Yan, Zhang, Xiao, Feng, Dan, Gao, Yani, Fu, Huiying, Zi, Wenjie, Yang, Qingwu, Qiu, Zhongming, and Wang, Shaojun

Published
2023
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11. Association of functional outcomes between intravenous tirofiban and endovascular thrombectomy in imaging-screened patients with large vessel occlusion stroke: a secondary analysis of randomized clinical trial

Author

Wang, Li, primary, Huang, Jiacheng, additional, Song, Jiaxing, additional, Yang, Jie, additional, Li, Linyu, additional, Guo, Changwei, additional, Yang, Qingwu, additional, Zi, Wenjie, additional, Li, Fengli, additional, and Kong, Weilin, additional

Published
2024
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12. Endovascular treatment versus standard medical treatment in patients with established large infarct: a cohort study

Author

Guo, Changwei, primary, Li, Linyu, additional, Huang, Jiandi, additional, Yang, Jie, additional, Song, Jiaxing, additional, Huang, Jiacheng, additional, Peng, Zhouzhou, additional, Yu, Nizhen, additional, Liu, Chang, additional, Kong, Weilin, additional, Hu, Jinrong, additional, Chen, Li, additional, Guo, Meng, additional, Yue, Chengsong, additional, Yang, Dahong, additional, Liu, Xiang, additional, Miao, Jian, additional, Wang, Mengmeng, additional, Luo, Xiangyun, additional, Tang, Zhaoyin, additional, Bai, Xiubing, additional, Wang, Duolao, additional, Li, Fengli, additional, Yang, Qingwu, additional, and Zi, Wenjie, additional

Published
2024
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14. Association of Renal Impairment with Clinical Outcomes Following Endovascular Therapy in Acute Basilar Artery Occlusion

Author

Cheng,Xiangping, Chen,Boyu, Chen,Xiaoyan, Song,Zhi, Li,Jie, Huang,Jiacheng, Kong,Weilin, Li,Jinglun, Cheng,Xiangping, Chen,Boyu, Chen,Xiaoyan, Song,Zhi, Li,Jie, Huang,Jiacheng, Kong,Weilin, and Li,Jinglun

Abstract

Xiangping Cheng,1,2,* Boyu Chen,3,* Xiaoyan Chen,4,* Zhi Song,2 Jie Li,2 Jiacheng Huang,4 Weilin Kong,4 Jinglun Li1 1Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China; 2Department of Neurology, The Gulin People’s Hospital, Luzhou, Sichuan Province, People’s Republic of China; 3Department of Cerebrovascular Diseases, Qujing No. 1 Hospital, Qujing, Yunnan, People’s Republic of China; 4Department of Neurology, Xinqiao Hospital and the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinglun Li, Department of Neurology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province, 646000, People’s Republic of China, Email ljl031611@163.com Weilin Kong, Department of Neurology, Xinqiao Hospital and the Second Affiliated Hospital, Army Medical University (Third Military Medical University), No. 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email kongweilin96@whu.edu.cnPurpose: Renal impairment (RI) is associated with unfavourable outcome after acute ischaemic stroke with anterior circulation large vessel occlusion. We assessed the association of RI with clinical outcomes in patients with acute basilar artery occlusion (ABAO), and the impact of RI on the effects of endovascular therapy (EVT) versus standard medical treatment (SMT).Patients and Methods: We used data from the BASILAR registry, an observational, prospective, nationwide study of patients with ABAO in routine clinical practice in China. Baseline estimated glomerular filtration rate (eGFR) was recorded at admission. The primary outcome was the modified Rankin Scale (mRS) score at 90 days. Secondary outcomes included favourable outcom

Published
2024

15. Protocol of the Fit-For-Fertility study: a multicentre randomised controlled trial assessing a lifestyle programme targeting women with obesity and infertility

Author

Stephanie-May Ruchat, B Taylor, Kristi Adamo, N Chaillet, Jean-Patrice Baillargeon, W Fraser, Kim Lavoie, Frances Gallagher, Matea Belan, Myriam Gélinas, Belina Carranza-Mamane, Marie-France Langlois, Anne-Sophie Morisset, Thomas Poder, Marie-Hélène Pesant, Farrah Jean-Denis, R Bouzayen, F Gallagher, A Godbout, E Greenblatt, C Kamga-Ngande, Kong Weilin, S Laredo, and M Sagle

Subjects
Medicine
Abstract

Introduction Women with obesity are at a higher risk of infertility as well as gestational and neonatal complications. Lifestyle changes are universally recommended for women with obesity seeking fertility treatments, but such intervention has only been assessed in very few robust studies. This study’s objectives are therefore to assess the clinical outcomes and cost-effectiveness of an interdisciplinary lifestyle intervention (the Fit-For-Fertility Programme; FFFP) targeting women with obesity and subfertility in a diverse population.Methods and analysis This pragmatic multicentre randomised controlled trial (RCT) will include 616 women with obesity (body mass index ≥30 kg/m2 or ≥27 kg/m2 with polycystic ovary syndrome or at-risk ethnicities) who are evaluated at a Canadian fertility clinic for subfertility. Women will be randomised either to (1) the FFFP (experimental arm) alone for 6 months, and then in combination with usual care for infertility if not pregnant; or (2) directly to usual fertility care (control arm). Women in the intervention group benefit from the programme up to 18 months or, if pregnant, up to 24 months or the end of the pregnancy (whichever comes first). Women from both groups are evaluated every 6 months for a maximum of 18 months. The primary outcome is live birth rate at 24 months. Secondary outcomes include fertility, pregnancy and neonatal outcomes; lifestyle and anthropometric measures; and cost-effectiveness. Qualitative data collected from focus groups of participants and professionals will also be analysed.Ethics and dissemination This research study has been approved by the Research Ethics Board (REB) of Centre intégré universtaire de santé et des services sociaux de l’Estrie—CHUS (research coordinating centre) on 10 December 2018 and has been or will be approved successively by each participating centres’ REB. This pragmatic RCT will inform decision-makers on improving care trajectories and policies regarding fertility treatments for women with obesity and subfertility.Trial registration number NCT03908099.Protocol version: 1.1, 13 April 2019

Published
2022
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18. Methylprednisolone as Adjunctive Therapy for Large Vessel Occlusion (MARVEL): a Randomized Double-blind, Placebo-controlled Trial in Patients undergoing Endovascular therapy: Study Rationale and Design

Author

Yang, Qing-Wu, primary, Guo, Changwei, additional, Yue, Chengsong, additional, Yang, Jie, additional, Li, Linyu, additional, Peng, Zhouzhou, additional, Hu, Jinrong, additional, Huang, Jiandi, additional, Song, Jiaxing, additional, Huang, Jiacheng, additional, Kong, Weilin, additional, Yu, Nizhen, additional, Yang, Dahong, additional, Liu, Xiang, additional, Wang, Duolao, additional, Nogueira, Raul G., additional, Li, Fengli, additional, Nguyen, Thanh N., additional, and Zi, Wenjie, additional

Published
2023
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21. Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

Author

Zi, Wenjie, primary, Song, Jiaxing, additional, Kong, Weilin, additional, Huang, Jiacheng, additional, Guo, Changwei, additional, He, Wencheng, additional, Yu, Yinquan, additional, Zhang, Bo, additional, Geng, Wanjie, additional, Tan, Xiaolin, additional, Tian, Yaoyu, additional, Liu, Zongtao, additional, Cao, Minghua, additional, Cheng, Daoyou, additional, Li, Bo, additional, Huang, Wenguo, additional, Liu, Junsheng, additional, Wang, Pengfei, additional, Yu, Zhou, additional, Liang, Hao, additional, Yang, Shuang, additional, Tang, Mingshan, additional, Liu, Wenhua, additional, Huang, Xianjun, additional, Liu, Shugai, additional, Tang, Yufeng, additional, Wu, Youlin, additional, Yao, Li, additional, Shi, Zhu, additional, He, Pengcheng, additional, Zhao, Haojin, additional, Chen, Zhuo, additional, Luo, Jun, additional, Wan, Yue, additional, Shi, Qiang, additional, Wang, Maorong, additional, Yang, De, additional, Chen, Xianglin, additional, Huang, Fang, additional, Mu, Jinlin, additional, Li, Hao, additional, Li, Zhimin, additional, Zheng, Jingbang, additional, Xie, Shunli, additional, Cai, Tieying, additional, Peng, Yuqi, additional, Xie, Weihua, additional, Qiu, Zhongming, additional, Liu, Chang, additional, Yue, Chengsong, additional, Li, Linyu, additional, Tian, Yan, additional, Yang, Dahong, additional, Miao, Jian, additional, Yang, Jie, additional, Hu, Jinrong, additional, Nogueira, Raul G., additional, Wang, Duolao, additional, Saver, Jeffrey L., additional, Li, Fengli, additional, and Yang, Qingwu, additional

Published
2023
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23. Association of Procedure Time With Clinical and Procedural Outcome in Patients With Basilar Occlusion Undergoing Embolectomy

Author

Guo, Changwei, primary, Song, Jiaxing, additional, Li, Linyu, additional, Yang, Jie, additional, Huang, Jiacheng, additional, Xie, Dongjing, additional, Yue, Chengsong, additional, Kong, Weilin, additional, Luo, Weidong, additional, Liu, Shuai, additional, Wang, Xiaoman, additional, Peng, Zhouzhou, additional, Fan, Shitao, additional, Xie, Yuqian, additional, Alawieh, Ali Mostafa, additional, Spiotta, Alejandro M, additional, Li, Fengli, additional, and Zi, Wenjie, additional

Published
2023
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26. Association between stress hyperglycemia and outcomes in patients with acute ischemic stroke due to large vessel occlusion

Author

Peng, Zhouzhou, primary, Song, Jiaxing, additional, Li, Linyu, additional, Guo, Changwei, additional, Yang, Jie, additional, Kong, Weilin, additional, Huang, Jiacheng, additional, Hu, Jinrong, additional, Liu, Shuai, additional, Tian, Yan, additional, Yang, Dahong, additional, Li, Fengli, additional, Zi, Wenjie, additional, Xie, Dongjing, additional, and Yang, Qingwu, additional

Published
2023
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27. First-pass effect in patients with acute basilar artery occlusions undergoing stent retriever thrombectomy

Author

Zhao, Chenhao, primary, Hu, Ting, additional, Kong, Weilin, additional, Yang, De, additional, Wan, Junfang, additional, Lv, Kefeng, additional, Liao, Jiasheng, additional, Chen, Zhao, additional, Jiang, He, additional, Wu, Deping, additional, Yang, Ping, additional, Zi, Wenjie, additional, Li, Fengli, additional, and Yang, Qingwu, additional

Published
2023
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29. Thrombectomy alone versus intravenous thrombolysis before thrombectomy for acute basilar artery occlusion

Author

Guo, Meng, Yue, Chengsong, Yang, Jie, Hu, Jinrong, Guo, Changwei, Peng, Zhouzhou, Xu, Rui, Yang, Dahong, Kong, Weilin, Liu, Xiang, Huang, Jiacheng, Tian, Yan, Li, Fengli, and Li, Chang-Qing

Abstract

BackgroundEndovascular treatment (EVT) is a well-established approach for acute ischemic stroke. Whether bridging intravenous thrombolysis (IVT) before EVT confers any benefits remains uncertain. The objective of the study was to compare the efficacy and safety of direct EVT with or without bridging IVT in patients with acute basilar artery occlusion (BAO).MethodsThis multicenter cohort study enrolled 647 patients with acute BAO who underwent either bridging IVT before EVT or direct EVT from the BASILAR registry. The primary outcome was an independent functional outcome measured by the modified Rankin Scale (mRS) score of 0–2. Secondary outcomes included excellent functional outcome (mRS 0–1), favorable functional outcome (mRS 0–3), and mortality rate at 90 days, as well as symptomatic intracranial hemorrhage (sICH), and successful reperfusion between the two treatment groups.ResultsDirect EVT and bridging IVT before EVT exhibited similar primary outcomes (27.3% vs 27.7%, respectively) and distributions of mRS scores at 90 days. Moreover, rates of sICH and 90-day mortality were not significantly different between the two groups (7.3% vs 6.0%, adjusted OR (aOR) 0.79, 95% CI 0.34 to 1.86, P=0.84 for sICH; 46.8% vs 43.7%, aOR 0.86, 95% CI 0.54 to 1.38, P=0.53 for mortality).ConclusionsAmong patients with acute BAO, functional outcomes were similar between those treated with bridging IVT before EVT and those treated with direct EVT, and there was no difference between the two groups in terms of sICH and mortality rates.

Published
2024
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30. Development and validation of machine learning-based model for mortality prediction in patients with acute basilar artery occlusion receiving endovascular treatment: multicentric cohort analysis

Author

Liu, Chang, Huang, Jiacheng, Kong, Weilin, Chen, Liyuan, Song, Jiaxing, Yang, Jie, Li, Fengli, and Zi, Wenjie

Abstract

BackgroundPredicting mortality in stroke patients using information available before endovascular treatment (EVT) is an essential component for supporting clinical decision-making. Although the mortality rate of acute basilar artery occlusion (ABAO) after EVT has reached 40%, few studies have focused on predicting mortality in these individuals. Thus, we aimed to develop and validate a machine learning-based mortality prediction tool based on preoperative information for ABAO patients receiving EVT.MethodsThe derivation cohort comprised patients from southern provinces of China in the BASILAR registry. The model (POSITIVE: Predicting mOrtality of baSilar artery occlusion patIents Treated wIth EVT) was trained and optimized using a fivefold cross-validation method in which hyperparameters were selected and fine-tuned. This model was retrospectively tested in patients from the northern provinces of China from the BASILAR registry. A prospective test of POSITIVE was performed on consecutive patients from two hospitals between January 2020 and June 2022.ResultsExtreme gradient boosting was employed to construct the POSITIVE model, which achieved the best predictive performance among the eight machine learning algorithms and showed excellent discrimination (area under the curve (AUC) 0.83, 95% confidence interval (95% CI) 0.80 to 0.87) and calibration (Hosmer-Lemeshow test, P>0.05) in the development cohort. AUC yielded by the POSITIVE model for the retrospective test was 0.79 (95% CI 0.71 to 0.85), higher than that obtained by traditional models. Prospective comparisons showed that the POSITIVE model achieved the highest AUC (0.82, 95% CI 0.74 to 0.90) among all prediction models.ConclusionWe developed a machine learning algorithm and retrospective and prospective testing with multicentric cohorts, which exhibited a solid predictive performance and may act as a convenient reference to guide decision-making for ABAO patients. The POSITIVE model is presented online for user-friendly access.

Published
2024
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31. Abstract WP13: Value Of Stress Hyperglycemia Ratio In Predicting The Prognosis Of Patients With Acute Ischemic Stroke:a Subgroup Analysis Of The Rescue Bt Clinical Trial

Author

Peng, Zhouzhou, primary, Song, Jiaxing, additional, Li, Linyu, additional, Guo, Changwei, additional, Yang, Jie, additional, Kong, Weilin, additional, Huang, Jiacheng, additional, Yue, Chengsong, additional, Hu, Jinrong, additional, Liu, Shuai, additional, Tian, Yan, additional, Yang, Dahong, additional, Liu, Xiang, additional, Zi, Wenjie, additional, Li, Fengli, additional, and Yang, Qingwu, additional

Published
2023
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37. Clinical Predictors for Early Mortality of Patients with Acute Basilar Artery Occlusion

Author

Huang, Jiacheng, primary, Wang, Maolin, additional, Li, Fengli, additional, Kong, Weilin, additional, Liu, Da, additional, Li, Huagang, additional, Zhou, Peiyang, additional, Yan, Zhizhong, additional, Wang, Yan, additional, Song, Jiaxing, additional, Luo, Weidong, additional, Liu, Shuai, additional, Li, Linyu, additional, Hu, Jinrong, additional, Tian, Yan, additional, Qiu, Zhongming, additional, Xu, Rui, additional, Schonewille, Wouter J., additional, Zi, Wenjie, additional, and Yang, Qingwu, additional

Published
2022
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38. Effect of the anastomosis between the posterior inferior cerebellar artery and the superior cerebellar artery on outcomes of acute basilar artery occlusion after endovascular treatment

Author

Huang, Jiacheng, primary, Kong, Weilin, additional, Yang, Jie, additional, Wang, Maolin, additional, Huang, Xianjun, additional, Wang, Yan, additional, Luo, Jun, additional, Wu, Youlin, additional, Zeng, Guoyong, additional, Wan, Yue, additional, Song, Jiaxing, additional, Li, Linyu, additional, Hu, Jinrong, additional, Liu, Shuai, additional, Luo, Weidong, additional, Tian, Yan, additional, Sang, Hongfei, additional, Qiu, Zhongming, additional, Li, Fengli, additional, Schonewille, Wouter, additional, Liu, Chang, additional, and Zi, Wenjie, additional

Published
2022
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39. Outcome of endovascular treatment in acute basilar artery occlusion with National Institutes of Health Stroke Scale score 10–19

Author

Huang, Jiacheng, primary, Kong, Weilin, additional, Qiu, Zhongming, additional, Liu, Da, additional, Li, Huagang, additional, Zhou, Peiyang, additional, Yan, Zhizhong, additional, Wang, Yan, additional, Dai, Weipeng, additional, Zheng, Chong, additional, Li, Rongzong, additional, Wang, Jian, additional, Song, Jiaxing, additional, Yuan, Junjie, additional, Luo, Weidong, additional, Liu, Shuai, additional, Li, Linyu, additional, Sang, Hongfei, additional, Li, Fengli, additional, Wu, Deping, additional, Yang, Qingwu, additional, and Zi, Wenjie, additional

Published
2022
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40. RESCUE BT 2, a multicenter, randomized, double-blind, double-dummy trial of intravenous tirofiban in acute ischemic stroke: Study rationale and design

Author

Zi, Wenjie, primary, Song, Jiaxing, additional, Qiu, Zhongming, additional, Kong, Weilin, additional, Huang, Jiacheng, additional, Luo, Weidong, additional, Liu, Shuai, additional, Sang, Hongfei, additional, Yang, Jie, additional, Li, Linyu, additional, Tian, Yan, additional, Hu, Jinrong, additional, Saver, Jeffrey L, additional, Nogueira, Raul G, additional, Li, Fengli, additional, and Yang, Qingwu, additional

Published
2022
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41. High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes

Author

Liao, Maofan, primary, Li, Fengli, additional, Hu, Jinrong, additional, Yang, Jie, additional, Wu, Deping, additional, Xie, Dongjing, additional, Song, Jiaxing, additional, Huang, Jiacheng, additional, Tian, Yan, additional, Luo, Weidong, additional, Yue, Chengsong, additional, Liu, Shuai, additional, Kong, Weilin, additional, Huang, Li, additional, Zi, Wenjie, additional, and Li, Fangfei, additional

Published
2022
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42. RESCUE BT 2, a multicenter, randomized, double-blind, double-dummy trial of intravenous tirofiban in acute ischemic stroke: Study rationale and design.

Author

Zi, Wenjie, Song, Jiaxing, Qiu, Zhongming, Kong, Weilin, Huang, Jiacheng, Luo, Weidong, Liu, Shuai, Sang, Hongfei, Yang, Jie, Li, Linyu, Tian, Yan, Hu, Jinrong, Saver, Jeffrey L, Nogueira, Raul G, Li, Fengli, and Yang, Qingwu

Subjects
ISCHEMIC stroke, THROMBOLYTIC therapy, TIROFIBAN, STROKE patients, ACUTE coronary syndrome, EXPERIMENTAL design, INTRACEREBRAL hematoma
Abstract

Background: Tirofiban is a glycoprotein IIb/IIIa receptor inhibitor that has been shown to be effective in the treatment of acute coronary syndromes. However, it remains unknown whether it improves outcomes in patients with acute ischemic stroke. Objective: This trial investigates the efficacy and safety of tirofiban compared with aspirin for acute ischemic stroke within 24 h after symptom onset. Methods and design: The Efficacy and Safety of Tirofiban Compared with Aspirin in the Treatment of Acute Ischemic Stroke (RESCUE BT 2) Trial is an investigator-initiated, prospective, randomized, double-blind, double-dummy, multicenter clinical trial. Up to 1158 eligible patients will be consecutively randomized to receive antiplatelet therapy with tirofiban or aspirin in 1:1 ratio across approximately 100 stroke centers in China. Outcomes: The primary endpoint is the proportion of patients with excellent functional outcomes defined as a modified Rankin scale score of 0 to 1 at 90 days after randomization. Lead safety endpoints include mortality at 90 days and symptomatic intracerebral hemorrhage within 48 h after treatment. Trial registry number: ChiCTR2000029502 (www.chictr.org.cn). [ABSTRACT FROM AUTHOR]

Published
2023
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43. Locked-in syndrome responding to endovascular treatment

Author

Song, Jiaxing, primary, Huang, Jiacheng, additional, Li, Linyu, additional, Yang, Jie, additional, Yue, Chengsong, additional, Liu, Shuai, additional, Kong, Weilin, additional, Luo, Xiaojun, additional, Liao, Jiasheng, additional, Du, Jie, additional, Song, Bo, additional, Liu, Jiazuo, additional, Tian, Xiaolong, additional, Tan, Xiaolin, additional, Li, Fengli, additional, and Zi, Wenjie, additional

Published
2022
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44. Effect of atrial fibrillation on outcomes after mechanical thrombectomy and long-term ischemic recurrence in patients with acute basilar artery occlusion

Author

Zhao, Chenhao, primary, Luo, Weidong, additional, Liu, Xing, additional, Luo, Jun, additional, Song, Jiaxing, additional, Yuan, Junjie, additional, Liu, Shuai, additional, Huang, Jiacheng, additional, Kong, Weilin, additional, Hu, Jinrong, additional, Yang, Jie, additional, Sun, Ruidi, additional, Yue, Chengsong, additional, Xie, Dongjing, additional, Li, Linyu, additional, Sang, Hongfei, additional, Qiu, Zhongming, additional, Li, Fengli, additional, Wu, Deping, additional, Zi, Wenjie, additional, and Yang, Qingwu, additional

Published
2022
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45. Five-Year Outcomes After Endovascular Treatment for Large Vessel Occlusion Stroke

Author

Gong, Changxiong, primary, Huang, Jiacheng, additional, Kong, Weilin, additional, Li, Fengli, additional, Liu, Chang, additional, Yang, Jie, additional, Liu, Shuai, additional, Qiu, Zhongming, additional, Lin, Min, additional, Guo, Zhangbao, additional, Yan, Zhizhong, additional, Huang, Xianjun, additional, Zhang, Shuai, additional, Ling, Wentong, additional, Zhou, Peiyang, additional, Wang, Zhen, additional, Liu, Yong, additional, Xue, Dongzhang, additional, Zhong, Yaoyi, additional, Yang, Shu, additional, Wan, Yue, additional, Fang, Jiayang, additional, Huang, Wenguo, additional, Liu, Huihui, additional, Luo, Jun, additional, Li, Rongzhong, additional, Wen, Changming, additional, Fu, Xinmin, additional, Tu, Mingyi, additional, Wang, Li, additional, Tian, Xiguang, additional, Peng, Huiyuan, additional, Wu, Zhilin, additional, Zeng, Guoyong, additional, Zi, Wenjie, additional, and Yang, Qingwu, additional

Published
2022
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46. Low neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict favorable outcomes after endovascular treatment in acute basilar artery occlusion

Author

Yang, Jie, primary, Kong, Weilin, additional, Song, Jiaxing, additional, Huang, Jiacheng, additional, Guo, Changwei, additional, Xie, Dongjing, additional, Yue, Chengsong, additional, Hu, Jinrong, additional, Luo, Weidong, additional, Liu, Shuai, additional, Li, Fengli, additional, and Zi, Wenjie, additional

Published
2022
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49. First Application of Nitrogen-Doped Carbon Nanosheets Derived from Lotus Leaves as the Electrode Catalyst for Li-CO 2 /O 2 Battery.

Author

Zou, Lu, Kong, Weilin, Peng, Linfeng, and Wang, Fang

Subjects
*ELECTRIC batteries, *DOPING agents (Chemistry), *NANOSTRUCTURED materials, *CATALYSTS, *CATALYTIC activity, *CARBON, *NITROGEN
Abstract

The development of Li-CO2/O2 battery with high energy density and long-term stability is urgently needed to fulfill the carbon neutralization and pollution-free environment targets. The biomass-derived heteroatom-doped carbon catalyst with the combination of high-efficiency catalytic activity and sustainable supply is a promising cathode catalyst in Li-CO2/O2 battery. Specifically, the unique morphology and mesopore structure can promote the transfer of CO2, O2, and Li+. Abundant channel pores can provide discharge products accommodation to the largest extent. Nitrogen dopant, the commonly recognized active sites in carbon, can improve the electron conductivity and accelerate the sluggish kinetic reaction. Therefore, utilizing the louts leaves as the precursor, we successfully prepare the cellular-like nitrogen-doped activated carbon nanosheets (N-CNs) through the appropriate pyrolysis carbonization method. The as-synthesized carbon nanosheets display a three-dimensional interconnecting pore structure and abundant N-dopant actives, which dramatically improve the electrochemical catalytic activity of N-CNs. The Li-CO2/O2 battery with the N-CNs cathode delivers a high discharge capacity of 9825 mAh g−1, low overpotential of 1.21 V, and stable cycling performance of 95 cycles. Thus, we carry out a facile method for N-doped carbon nanosheets preparation derived from the cheap natural biomass, which can be the effective cathode catalyst for environmental-friendly Li-CO2/O2 battery. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Clinical Predictors for Early Mortality of Patients with Acute Basilar Artery Occlusion.

Author

Huang, Jiacheng, Wang, Maolin, Li, Fengli, Kong, Weilin, Liu, Da, Li, Huagang, Zhou, Peiyang, Yan, Zhizhong, Wang, Yan, Song, Jiaxing, Luo, Weidong, Liu, Shuai, Li, Linyu, Hu, Jinrong, Tian, Yan, Qiu, Zhongming, Xu, Rui, Schonewille, Wouter J., Zi, Wenjie, and Yang, Qingwu

Subjects
BASILAR artery, ARTERIAL occlusions, ISCHEMIC stroke, MORTALITY risk factors, GASTROINTESTINAL hemorrhage
Abstract

Background: Acute ischemic stroke due to basilar artery occlusion (BAO) is associated with the highest mortality in patients with large vessel occlusion. This study aimed to identify modifiable risk factors of early mortality in patients with BAO. Methods and Results: This was a cohort study of consecutive patients with BAO admitted to 47 stroke centers in China between January 2014 and May 2019. The primary outcome was all-cause mortality within 7 days after hospitalization. Of 829 patients, 164 died (0–3 days: 115; 4–7 days: 49) within 7 days after hospitalization. Among pre- and periprocedural variables, higher admission National Institutes of Health Stroke Scale (NIHSS, adjusted OR, 1.06, 95% CI: 1.04–1.09; p < 0.001), lower admission posterior circulation-Alberta Stroke Program Early Computed Tomography Score (pc-ASPECTS, adjusted OR, 0.88, 95% CI: 0.79–0.98; p = 0.02), lower Basilar Artery on Computed Tomography Angiography score (BATMAN, adjusted OR, 0.84, 95% CI: 0.76–0.93; p = 0.001), and recanalization failure (adjusted OR, 2.99, 95% CI: 2.04–4.38; p < 0.001) were independently associated with a higher risk of early mortality. Herniation (adjusted OR, 2.84, 95% CI: 1.52–5.30; p = 0.001) is an independent postprocedural predictor of early mortality. In patients dying ≤3 days, higher NIHSS (p < 0.001), lower pc-ASPECTS (p = 0.01), lower BATMAN (p = 0.004), recanalization failure (p < 0.001), herniation (p = 0.001), gastrointestinal hemorrhage (p = 0.046), and absence of pneumonia (p < 0.001) were independent predictors of early mortality. Higher NIHSS (p = 0.01), recanalization failure (p < 0.001), and pneumonia (p = 0.03) were independently associated with early mortality between 4 and 7 days. Conclusions: Recanalization failure, herniation, gastrointestinal hemorrhage, and pneumonia are potentially modifiable risk factors for early mortality in basilar artery occlusion. [ABSTRACT FROM AUTHOR]

Published
2023
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