Search

Your search keyword '"Kong, Pengzhou"' showing total 154 results
Start Over Author "Kong, Pengzhou"
154 results on '"Kong, Pengzhou"'

3. Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma

Author

Liu, Zhihua, Zhao, Yahui, Kong, Pengzhou, Liu, Yuhao, Huang, Jing, Xu, Enwei, Wei, Wenqing, Li, Guangyu, Cheng, Xiaolong, Xue, Liyan, Li, Yi, Chen, Hongyan, Wei, Shuqing, Sun, Ruifang, Cui, Heyang, Meng, Yongsheng, Liu, Meilin, Li, Yang, Feng, Riyue, Yu, Xiao, Zhu, Rui, Wu, Yenan, Li, Lei, Yang, Bin, Ma, Yanchun, Wang, Jiawei, Zhu, Wenjie, Deng, Dongjie, Xi, Yanfeng, Wang, Fang, Li, Hongyi, Guo, Shiping, Zhuang, Xiaofei, Wang, Xiaoyue, Jiao, Yuchen, Cui, Yongping, and Zhan, Qimin

Published
2023
Full Text
View/download PDF

4. KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5‐Mediated Tryptophan Metabolism.

Author

Chai, Bao, Zhang, Anhong, Liu, Yang, Zhang, Xi, Kong, Pengzhou, Zhang, Zhuowei, and Guo, Yarong

Subjects
CELL migration, HEPATOCELLULAR carcinoma, CELL proliferation, SEROTONIN, ONCOGENES
Abstract

Krüppel‐like factor 7 is a transcriptional activator and acts as an oncogene in human cancers, including hepatocellular carcinoma (HCC). Tryptophan metabolism is important for HCC cell proliferation, metastasis, and invasion. It is unclear whether KLF7 could regulate Trp metabolism in HCC. In this study, we found that Trp metabolism was suppressed in HCC cells with KLF7 knockdown. The mRNA and protein levels of SLC1A5, SLC7A5, and TPH1, as well as the content of Trp and serotonin, were reduced after KLF7 knockdown, and were potentiated following KLF7 overexpression. Increasing the content of serotonin could restore the malignancy of tumour cells in vitro and tumour growth in vivo. Conversely, decreasing the content of serotonin suppressed HCC cell proliferation. The binding activity of KLF7 was on the promoter of SLC1A5, and KLF7 positively regulated the expression of SLC1A5. KLF7 contributed to the proliferation and migration of HCC cells by up‐regulation of SLC1A5. Collectively, KLF7 promotes the progression of HCC through regulating Trp metabolism. The newly identified axis of KLF7/ SLC1A5 in HCC could represent a potential target for HCC therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

Author

Cui, Yongping, Chen, Hongyan, Xi, Ruibin, Cui, Heyang, Zhao, Yahui, Xu, Enwei, Yan, Ting, Lu, Xiaomei, Huang, Furong, Kong, Pengzhou, Li, Yang, Zhu, Xiaolin, Wang, Jiawei, Zhu, Wenjie, Wang, Jie, Ma, Yanchun, Zhou, Yong, Guo, Shiping, Zhang, Ling, Liu, Yiqian, Wang, Bin, Xi, Yanfeng, Sun, Ruifang, Yu, Xiao, Zhai, Yuanfang, Wang, Fang, Yang, Jian, Yang, Bin, Cheng, Caixia, Liu, Jing, Song, Bin, Li, Hongyi, Wang, Yi, Zhang, Yingchun, Cheng, Xiaolong, Zhan, Qimin, Li, Yanhong, and Liu, Zhihua

Published
2020
Full Text
View/download PDF

8. Author Correction: Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

Author

Cui, Yongping, Chen, Hongyan, Xi, Ruibin, Cui, Heyang, Zhao, Yahui, Xu, Enwei, Yan, Ting, Lu, Xiaomei, Huang, Furong, Kong, Pengzhou, Li, Yang, Zhu, Xiaolin, Wang, Jiawei, Zhu, Wenjie, Wang, Jie, Ma, Yanchun, Zhou, Yong, Guo, Shiping, Zhang, Ling, Liu, Yiqian, Wang, Bin, Xi, Yanfeng, Sun, Ruifang, Yu, Xiao, Zhai, Yuanfang, Wang, Fang, Yang, Jian, Yang, Bin, Cheng, Caixia, Liu, Jing, Song, Bin, Li, Hongyi, Wang, Yi, Zhang, Yingchun, Cheng, Xiaolong, Zhan, Qimin, Li, Yanhong, and Liu, Zhihua

Published
2022
Full Text
View/download PDF

9. FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer

Author

Hu, Xiaoling, Zhai, Yuanfang, Kong, Pengzhou, Cui, Heyang, Yan, Ting, Yang, Jian, Qian, Yu, Ma, Yanchun, Wang, Fang, Li, Hongyi, Cheng, Caixia, Zhang, Ling, Jia, Zhiwu, Li, Yaoping, Yang, Bin, Xu, Enwei, Wang, Juan, Yang, Jie, Bi, Yanghui, Chang, Lu, Wang, Yi, Zhang, Yingchun, Song, Bin, Li, Guodong, Shi, Ruyi, Liu, Jing, Zhang, Mingsheng, Cheng, Xiaolong, and Cui, Yongping

Published
2017
Full Text
View/download PDF

10. Author Correction: Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Author

Yan, Ting, Cui, Heyang, Zhou, Yong, Yang, Bin, Kong, Pengzhou, Zhang, Yingchun, Liu, Yiqian, Wang, Bin, Cheng, Yikun, Li, Jiayi, Guo, Shixing, Xu, Enwei, Liu, Huijuan, Cheng, Caixia, Zhang, Ling, Chen, Ling, Zhuang, Xiaofei, Qian, Yu, Yang, Jian, Ma, Yanchun, Li, Hongyi, Wang, Fang, Liu, Jing, Liu, Xuefeng, Su, Dan, Wang, Yan, Sun, Ruifang, Guo, Shiping, Li, Yaoping, Cheng, Xiaolong, Liu, Zhihua, Zhan, Qimin, and Cui, Yongping

Published
2020
Full Text
View/download PDF

13. Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma

Author

Bi, Yanghui, Guo, Shixing, Xu, Xiaoqin, Kong, Pengzhou, Cui, Heyang, Yan, Ting, Ma, Yanchun, Cheng, Yikun, Chen, Yunqing, Liu, Xue, Zhang, Ling, Cheng, Caixia, Xu, Enwei, Qian, Yu, Yang, Jian, Song, Bin, Li, Hongyi, Wang, Fang, Hu, Xiaoling, Liu, Xiangchen, Niu, Xia, Zhai, Yuanfang, Liu, Jing, Li, Yaoping, Cheng, Xiaolong, and Cui, Yongping

Published
2020
Full Text
View/download PDF

15. Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma

Author

Cheng, Caixia, Zhou, Yong, Li, Hongyi, Xiong, Teng, Li, Shuaicheng, Bi, Yanghui, Kong, Pengzhou, Wang, Fang, Cui, Heyang, Li, Yaoping, Fang, Xiaodong, Yan, Ting, Li, Yike, Wang, Juan, Yang, Bin, Zhang, Ling, Jia, Zhiwu, Song, Bin, Hu, Xiaoling, Yang, Jie, Qiu, Haile, Zhang, Gehong, Liu, Jing, Xu, Enwei, Shi, Ruyi, Zhang, Yanyan, Liu, Haiyan, He, Chanting, Zhao, Zhenxiang, Qian, Yu, Rong, Ruizhou, Han, Zhiwei, Zhang, Yanlin, Luo, Wen, Wang, Jiaqian, Peng, Shaoliang, Yang, Xukui, Li, Xiangchun, Li, Lin, Fang, Hu, Liu, Xingmin, Ma, Li, Chen, Yunqing, Guo, Shiping, Chen, Xing, Xi, Yanfeng, Li, Guodong, Liang, Jianfang, Yang, Xiaofeng, Guo, Jiansheng, Jia, JunMei, Li, Qingshan, Cheng, Xiaolong, Zhan, Qimin, and Cui, Yongping

Published
2016
Full Text
View/download PDF

16. Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Author

Yan, Ting, Cui, Heyang, Zhou, Yong, Yang, Bin, Kong, Pengzhou, Zhang, Yingchun, Liu, Yiqian, Wang, Bin, Cheng, Yikun, Li, Jiayi, Guo, Shixing, Xu, Enwei, Liu, Huijuan, Cheng, Caixia, Zhang, Ling, Chen, Ling, Zhuang, Xiaofei, Qian, Yu, Yang, Jian, Ma, Yanchun, Li, Hongyi, Wang, Fang, Liu, Jing, Liu, Xuefeng, Su, Dan, Wang, Yan, Sun, Ruifang, Guo, Shiping, Li, Yaoping, Cheng, Xiaolong, Liu, Zhihua, Zhan, Qimin, and Cui, Yongping

Published
2019
Full Text
View/download PDF

17. PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells

Author

Zhao,Yujing, Wu,Juan, Guan,Shuai, Xue,Ting, Wei,Xiaolei, Cao,Dawei, Kong,Pengzhou, Zhang,Xinri, Zhao,Yujing, Wu,Juan, Guan,Shuai, Xue,Ting, Wei,Xiaolei, Cao,Dawei, Kong,Pengzhou, and Zhang,Xinri

Abstract

Yujing Zhao,1– 4 Juan Wu,2– 4 Shuai Guan,5 Ting Xue,2– 4 Xiaolei Wei,1– 4 Dawei Cao,2– 4 Pengzhou Kong,6 Xinri Zhang2– 4 1Department of the First Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of NHC Key Laboratory of Pneumoconiosis, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 3Department of Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 5Department of Pediatric Infectious Diseases, The First People’s Hospital of Datong, Datong, Shanxi, People’s Republic of China; 6Department of Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Pengzhou Kong, Department of Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email kongpengzhou@sxmu.edu.cn Xinri Zhang, Department of Pulmonary and Critical Care Medicine, NHC Key Laboratory of Pneumoconiosis; Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email ykdzxr61@163.comPurpose: Pulmonary artery hypertension (PAH) is a common complication of chronic obstructive pulmonary disease and obstructive sleep apnea/hypopnea syndrome worldwide. Pulmonary vascular alterations associated with PAH have multifactorial causes, in which endothelial cells play an important role. Autophagy is closely related to endothelial cell injury and the development of PAH. PIF1 is a multifunctional helicase crucial for cell survival. The present study investigated the effect of PIF1 on autophagy and apoptosis in human pulmonary artery endothelial cells (HPAECs) u

Published
2023

19. Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma

Author

Zhang, Ling, Zhou, Yong, Cheng, Caixia, Cui, Heyang, Cheng, Le, Kong, Pengzhou, Wang, Jiaqian, Li, Yin, Chen, Wenliang, Song, Bin, Wang, Fang, Jia, Zhiwu, Li, Lin, Li, Yaoping, Yang, Bin, Liu, Jing, Shi, Ruyi, Bi, Yanghui, Zhang, Yanyan, Wang, Juan, Zhao, Zhenxiang, Hu, Xiaoling, Yang, Jie, Li, Hongyi, Gao, Zhibo, Chen, Gang, Huang, Xuanlin, Yang, Xukui, Wan, Shengqing, Chen, Chao, Li, Bin, Tan, Yongkai, Chen, Longyun, He, Minghui, Xie, Sha, Li, Xiangchun, Zhuang, Xuehan, Wang, Mengyao, Xia, Zhi, Luo, Longhai, Ma, Jie, Dong, Bing, Zhao, Jiuzhou, Song, Yongmei, Ou, Yunwei, Li, Enming, Xu, Liyan, Wang, Jinfen, Xi, Yanfeng, Li, Guodong, Xu, Enwei, Liang, Jianfang, Yang, Xiaofeng, Guo, Jiansheng, Chen, Xing, Zhang, Yanbo, Li, Qingshan, Liu, Lixin, Li, Yingrui, Zhang, Xiuqing, Yang, Huanming, Lin, Dongxin, Cheng, Xiaolong, Guo, Yongjun, Wang, Jun, Zhan, Qimin, and Cui, Yongping

Published
2015
Full Text
View/download PDF

23. Integrative Genomic Analyses of 1,145 Patient Samples Reveal New Biomarkers in Esophageal Squamous Cell Carcinoma

Author

Zou, Binbin, Guo, Dinghe, Kong, Pengzhou, Wang, Yangqiang, Cheng, Xiaolong, Cui, Yongping, Zou, Binbin, Guo, Dinghe, Kong, Pengzhou, Wang, Yangqiang, Cheng, Xiaolong, and Cui, Yongping

Abstract

Due to the lack of effective diagnostic markers and therapeutic targets, esophageal squamous cell carcinoma (ESCC) shows a poor 5 years survival rate of less than 30%. To explore the potential therapeutic targets of ESCC, we integrated and reanalyzed the mutation data of WGS (whole genome sequencing) or WES (whole exome sequencing) from a total of 1,145 samples in 7 large ESCC cohorts, including 270 ESCC gene expression data. Two new mutation signatures and 20 driver genes were identified in our study. Among them, AP3S1, MUC16, and RPS15 were reported for the first time. We also discovered that the KMT2D was associated with the multiple clinical characteristics of ESCC, and KMT2D knockdown cells showed enhanced cell migration and cell invasion. Furthermore, a few neoantigens were shared between ESCC patients. For ESCC, compared to TMB, neoantigen might be treated as a better immunotherapy biomarker. Our research expands the understanding of ESCC mutations and helps the identification of ESCC biomarkers, especially for immunotherapy biomarkers. Copyright © 2022 Zou, Guo, Kong, Wang, Cheng and Cui.

Published
2022

28. CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC.

Author

Li, Hongyi, Wang, Shaojie, Li, Xiubo, Weng, Yongjia, Guo, Dinghe, Kong, Pengzhou, Cheng, Caixia, Wang, Yanqiang, Zhang, Ling, Cheng, Xiaolong, and Cui, Yongping

Abstract

Cell division cycle associated 7 (CDCA7) is a copy number amplification gene that contributes to the metastasis and invasion of tumors, including esophageal squamous cell carcinoma (ESCC). This present study aimed at clarifying whether high expression of CDCA7 promotes the metastasis and invasion of ESCC cell lines and exploring the underlying mechanisms implicated in epithelial–mesenchymal transition (EMT) of ESCC. The role of CDCA7 in the regulation of ESCC metastasis and invasion was evaluated using ESCC cell lines. Expression of EMT‐related markers including E‐cadherin, N‐cadherin, Vimentin, Snail, and Slug, transforming growth factor β (TGF‐β) signaling pathway including Smad2/3, p‐Smad2/3, Smad4, and Smad7 were detected in CDCA7 knockdown and overexpressed cell lines. Dual‐luciferase reporter assay and rescue assay were used to explore the underlying mechanisms that CDCA7 contributed to the metastasis and invasion of ESCC. High CDCA7 expression significantly promoted the metastasis and invasion of ESCC cell lines both in vivo and in vitro. Additionally, the expression of CDCA7 positively correlated with the expression of N‐cadherin, Vimentin, Snail, Slug, TGF‐β signaling pathway and negatively correlated with the expression of E‐cadherin. Furthermore, CDCA7 transcriptionally regulated the expression of Smad4 and Smad7. Knockdown of CDCA7 inhibited the TGF‐β signaling pathway and therefore inhibited EMT. Our data indicated that CDCA7 was heavily involved in EMT by regulating the expression of Smad4 and Smad7 in TGF‐β signaling pathway. CDCA7 might be a new therapeutic target in the suppression of metastasis and invasion of ESCC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

29. CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma

Author

Li, Hongyi, primary, Weng, Yongjia, additional, Wang, Shaojie, additional, Wang, Fang, additional, Wang, Yanqiang, additional, Kong, Pengzhou, additional, Zhang, Ling, additional, Cheng, Caixia, additional, Cui, Heyang, additional, Xu, Enwei, additional, Wei, Shuqing, additional, Guo, Dinghe, additional, Chen, Fei, additional, Bi, Yanghui, additional, Meng, Yongsheng, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2021
Full Text
View/download PDF

32. Corrigendum to “FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer” [Canc. Lett. 397 (2017) 83–93]

Author

Hu, Xiaoling, primary, Zhai, Yuanfang, additional, Kong, Pengzhou, additional, Cui, Heyang, additional, Yan, Ting, additional, Yang, Jian, additional, Qian, Yu, additional, Ma, Yanchun, additional, Wang, Fang, additional, Li, Hongyi, additional, Cheng, Caixia, additional, Zhang, Ling, additional, Jia, Zhiwu, additional, Li, Yaoping, additional, Yang, Bin, additional, Xu, Enwei, additional, Wang, Juan, additional, Yang, Jie, additional, Bi, Yanghui, additional, Chang, Lu, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Song, Bin, additional, Li, Guodong, additional, Shi, Ruyi, additional, Liu, Jing, additional, Zhang, Mingsheng, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2020
Full Text
View/download PDF

33. Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma

Author

Zhang, Ling, primary, Zhou, Yong, additional, Cheng, Caixia, additional, Cui, Heyang, additional, Cheng, Le, additional, Kong, Pengzhou, additional, Wang, Jiaqian, additional, Li, Yin, additional, Chen, Wenliang, additional, Song, Bin, additional, Wang, Fang, additional, Jia, Zhiwu, additional, Li, Lin, additional, Li, Yaoping, additional, Yang, Bin, additional, Liu, Jing, additional, Shi, Ruyi, additional, Bi, Yanghui, additional, Zhang, Yanyan, additional, Wang, Juan, additional, Zhao, Zhenxiang, additional, Hu, Xiaoling, additional, Yang, Jie, additional, Li, Hongyi, additional, Gao, Zhibo, additional, Chen, Gang, additional, Huang, Xuanlin, additional, Yang, Xukui, additional, Wan, Shengqing, additional, Chen, Chao, additional, Li, Bin, additional, Tan, Yongkai, additional, Chen, Longyun, additional, He, Minghui, additional, Xie, Sha, additional, Li, Xiangchun, additional, Zhuang, Xuehan, additional, Wang, Mengyao, additional, Xia, Zhi, additional, Luo, Longhai, additional, Ma, Jie, additional, Dong, Bing, additional, Zhao, Jiuzhou, additional, Song, Yongmei, additional, Ou, Yunwei, additional, Li, Enming, additional, Xu, Liyan, additional, Wang, Jinfen, additional, Xi, Yanfeng, additional, Li, Guodong, additional, Xu, Enwei, additional, Liang, Jianfang, additional, Yang, Xiaofeng, additional, Guo, Jiansheng, additional, Chen, Xing, additional, Zhang, Yanbo, additional, Li, Qingshan, additional, Liu, Lixin, additional, Li, Yingrui, additional, Zhang, Xiuqing, additional, Yang, Huanming, additional, Lin, Dongxin, additional, Cheng, Xiaolong, additional, Guo, Yongjun, additional, Wang, Jun, additional, Zhan, Qimin, additional, and Cui, Yongping, additional

Published
2020
Full Text
View/download PDF

34. TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2

Author

Zhang, Ling, primary, Gao, Yingzhen, additional, Zhang, Xiaojuan, additional, Guo, Min, additional, Yang, Jie, additional, Cui, Heyang, additional, Kong, Pengzhou, additional, Niu, Xia, additional, Bi, Yanghui, additional, Xu, Jing, additional, Yan, Ting, additional, Ma, Yanchun, additional, Yang, Jian, additional, Qian, Yu, additional, Wang, Fang, additional, Li, Hongyi, additional, Liu, Feng, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2020
Full Text
View/download PDF

36. Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC

Author

Kong, Pengzhou, primary, Xu, Enwei, additional, Bi, Yanghui, additional, Xu, Xiaoqin, additional, Liu, Xue, additional, Song, Bin, additional, Zhang, Ling, additional, Cheng, Caixia, additional, Yan, Ting, additional, Qian, Yu, additional, Yang, Jian, additional, Ma, Yanchun, additional, Cui, Heyang, additional, Zhai, Yuanfang, additional, Zou, Binbin, additional, Liu, Xiangchen, additional, Cheng, Yikun, additional, Guo, Shiping, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2020
Full Text
View/download PDF

37. Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway

Author

Kong Pengzhou, Wang Lu, Cui Yong-ping, Yan Ting, Cheng Xiao-long, Li Hongyi, Ma Yanchun, Yang Jian, Qian Yu, Wang Fang, and Wang Yi

Subjects
0301 basic medicine, MAPK/ERK pathway, Cell cycle checkpoint, Esophageal Neoplasms, MAP Kinase Signaling System, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, Animals, Humans, Neoplasm Metastasis, Extracellular Signal-Regulated MAP Kinases, neoplasms, Cyclin, Cell Proliferation, Pharmacology, Kinase, Cell growth, Cell Cycle Checkpoints, Triptolide, Phenanthrenes, Xenograft Model Antitumor Assays, digestive system diseases, 030104 developmental biology, chemistry, Apoptosis, Cancer research, Epoxy Compounds, Esophageal Squamous Cell Carcinoma, Signal transduction, Diterpenes, Mitogen-Activated Protein Kinases, 030217 neurology & neurosurgery
Abstract

Triptolide, the component of traditional Chinese herb, has been used as an inflammatory medicine and reported to be anti-tumor for various cancers recently. However, the effect of triptolide on Esophageal Squamous Cell Cancer (ESCC) has not yet been elucidated. In the study, we found that triptolide significantly inhibited cell proliferation, invasion, migration and survivability of ESCC cells. Moreover, we observed that triptolide induced ESCC cell cycle arrest at the G1/S phase and apoptosis through cyclin D1-CDK4/6 regulation and caspases activation. In addition, we revealed that triptolide regulates cell apoptosis and metastasis by p53 and mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway, respectively. Meanwhile, the inhibitory effect of triptolide on ESCC was validated in mouse xenograft model. So, we propose that triptolide may be a candidate drug for ESCC.

Published
2018

39. Whole Genome Sequencing of 508 Patients Identified Key Molecular Features Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma

Author

Cui, Yongping, primary, Chen, Hongyan, additional, Xi, Ruibin, additional, Cui, Heyang, additional, Zhao, Yahui, additional, Yan, Ting, additional, Xu, Enwei, additional, Lu, Xiaomei, additional, Huang, Furong, additional, Kong, Pengzhou, additional, Li, Yang, additional, Zhu, Xiaolin, additional, Wang, Jiawei, additional, Zhu, Wenjie, additional, Wang, Jie, additional, Ma, Yanchun, additional, Zhou, Yong, additional, Guo, Shiping, additional, Zhang, Ling, additional, Liu, Yiqian, additional, Wang, Bin, additional, Xi, Yanfeng, additional, Sun, Ruifang, additional, Yu, Xiao, additional, Zhai, Yuanfang, additional, Wang, Fang, additional, Yang, Jian, additional, Yang, Bin, additional, Cheng, Caixia, additional, Liu, Jing, additional, Song, Bin, additional, Li, Hongyi, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Cheng, Xiaolong, additional, Li, Yanhong, additional, Liu, Zhihua, additional, and Zhan, Qimin, additional

Published
2019
Full Text
View/download PDF

40. EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma

Author

Bi, Yanghui, primary, Kong, Pengzhou, additional, Zhang, Ling, additional, Cui, Heyang, additional, Xu, Xiaoqin, additional, Chang, Feiyun, additional, Yan, Ting, additional, Li, Jiayi, additional, Cheng, Caixia, additional, Song, Bin, additional, Niu, Xia, additional, Liu, Xiangchen, additional, Liu, Xue, additional, Xu, Enwei, additional, Hu, Xiaoling, additional, Qian, Yu, additional, Wang, Fang, additional, Li, Hongyi, additional, Ma, Yanchun, additional, Yang, Jian, additional, Liu, Yiqian, additional, Zhai, Yuanfang, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Liu, Haiyan, additional, Liu, Jing, additional, Wang, Jintao, additional, Cui, Yongping, additional, and Cheng, Xiaolong, additional

Published
2019
Full Text
View/download PDF

41. Mps1 is associated with the BRAFV600E mutation but does not rely on the classic RAS/RAF/MEK/ERK signaling pathway in thyroid carcinoma

Author

Li, Yike, primary, Zhang, Yanyan, additional, Xiao, Shuaishuai, additional, Kong, Pengzhou, additional, Cheng, Caixia, additional, Shi, Ruyi, additional, Wang, Fang, additional, Zhang, Ling, additional, Wang, Juan, additional, Jia, Zhiwu, additional, Wu, Shuai, additional, Liu, Yun, additional, Guo, Jiansheng, additional, Cheng, Xiaolong, additional, Cui, Yongping, additional, and Liu, Jing, additional

Published
2018
Full Text
View/download PDF

42. FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma

Author

Hu, Xiaoling, primary, Zhai, Yuanfang, additional, Shi, Ruyi, additional, Qian, Yu, additional, Cui, Heyang, additional, Yang, Jie, additional, Bi, Yanghui, additional, Yan, Ting, additional, Yang, Jian, additional, Ma, Yanchun, additional, Zhang, Ling, additional, Liu, Yiqian, additional, Li, Guodong, additional, Zhang, Mingsheng, additional, Cui, Yongping, additional, Kong, Pengzhou, additional, and Cheng, Xiaolong, additional

Published
2018
Full Text
View/download PDF

43. WITHDRAWN: Potential therapeutic targets screening for esophageal squamous cell carcinoma via combined analysis of genomic sequencing data and target pharmacophore database

Author

Zhang, Ling, primary, Liu, Feng, additional, Bi, Yanghui, additional, Cui, Heyang, additional, Kong, Pengzhou, additional, Li, Jiayi, additional, Song, Bin, additional, Zou, Binbin, additional, Cheng, Caixia, additional, Yan, Ting, additional, Yang, Jian, additional, Qian, Yu, additional, Ma, Yanchun, additional, Wang, Fang, additional, Li, Hongyi, additional, Jia, Zhiwu, additional, Hu, Xiaoling, additional, Yang, Bin, additional, Xu, Enwei, additional, Li, Yaoping, additional, Wang, Juan, additional, Yang, Jie, additional, Zhai, Yuanfang, additional, Liu, Yiqian, additional, Chang, Lu, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Shi, Ruyi, additional, Jia, Junmei, additional, Liu, Jing, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2018
Full Text
View/download PDF

44. High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC

Author

Yang, Jie, primary, Kong, Pengzhou, additional, Yang, Jian, additional, Jia, Zhiwu, additional, Hu, Xiaoling, additional, Wang, Zianyi, additional, Cui, Heyang, additional, Bi, Yanghui, additional, Qian, Yu, additional, Li, Hongyi, additional, Wang, Fang, additional, Yang, Bin, additional, Yan, Ting, additional, Ma, Yanchun, additional, Zhang, Ling, additional, Cheng, Caixia, additional, Song, Bin, additional, Li, Yaoping, additional, Xu, Enwei, additional, Liu, Haiyan, additional, Gao, Wei, additional, Wang, Juan, additional, Liu, Yiqian, additional, Zhai, Yuanfang, additional, Chang, Lu, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Shi, Ruyi, additional, Liu, Jing, additional, Wang, Qi, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2018
Full Text
View/download PDF

45. WITHDRAWN: EP300 promotes tumor development and correlates with poor prognosis in esophageal squamous carcinoma

Author

Bi, Yanghui, primary, Zhang, Ling, additional, Cui, Heyang, additional, Kong, Pengzhou, additional, Yan, Ting, additional, Li, Jiayi, additional, Wang, Zianyi, additional, Cheng, Caixia, additional, Song, Bin, additional, Yang, Bin, additional, Xu, Enwei, additional, Yang, Jie, additional, Hu, Xiaoling, additional, Shi, Ruyi, additional, Qian, Yu, additional, Wang, Fang, additional, Li, Hongyi, additional, Jia, Zhiwu, additional, Ma, Yanchun, additional, Yang, Jian, additional, Li, Yike, additional, Wang, Juan, additional, Liu, Yiqian, additional, Zhai, Yuanfang, additional, Chang, Lu, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Liu, Feng, additional, Liu, Haiyan, additional, Zhang, Yanyan, additional, Liu, Jing, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2017
Full Text
View/download PDF

46. The macro-evolutionary events in esophageal squamous cell carcinoma

Author

Yang, Bin, primary, Yan, Ting, additional, Cui, Heyang, additional, Xu, Enwei, additional, Ma, Yanchun, additional, Cheng, Caixia, additional, Zhang, Ling, additional, Kong, Pengzhou, additional, Wang, Fang, additional, Qian, Yu, additional, Yang, Jian, additional, Li, Yaoping, additional, Li, Hongyi, additional, Bi, Yanghui, additional, Hu, Xiaoling, additional, Wang, Juan, additional, Song, Bin, additional, Yang, Jie, additional, Gao, Wei, additional, Liu, Jing, additional, Zou, Binbin, additional, Shi, Ruyi, additional, Zhang, Yanyan, additional, Liu, Haiyan, additional, Liu, Yiqian, additional, Zhai, Yuanfang, additional, Chang, Lu, additional, Wang, Yi, additional, Zhang, Yingchun, additional, Jia, Zhiwu, additional, Chen, Xing, additional, Xi, Yanfeng, additional, Li, Guodong, additional, Liang, Jianfang, additional, Guo, Jiansheng, additional, Guo, Shiping, additional, Zhang, Rongsheng, additional, Cheng, Xiaolong, additional, and Cui, Yongping, additional

Published
2017
Full Text
View/download PDF

47. Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer.

Author

Zhang, Yanyan, Dong, Jinyao, Shi, Ruyi, Feng, Liguo, Li, Yike, Cheng, Caixia, Zhang, Ling, Song, Bin, Bi, Yanghui, Huang, He, Kong, Pengzhou, Guo, Jiansheng, and Liu, Jing

Subjects
COLORECTAL cancer, PROTEIN kinases, TUMOR classification, SURVIVAL analysis (Biometry), CANCER patients, MELANOMA, HEREDITARY nonpolyposis colorectal cancer
Abstract

Colorectal cancer (CRC) with the V600E mutation of B-Raf proto-oncogene serine/threonine kinase (BRAFV600E) mutation is insensitive to chemotherapy and is indicative of a poor patient prognosis. Although BRAF inhibitors have a marked effect on malignant melanoma harboring the BRAFV600E mutation, they have a limited effect on patients with CRC with the same BRAF mutation. A previous study identified a novel gene, monopolar spindle protein kinase 1 (Mps1), a downstream target of BRAFV600E only, rather than of wild-type BRAF as well, which contributes to tumorigenesis in melanoma. In the present study, the incidence of BRAFV600E in patients with CRC was identified and the correlation of Mps1, phospho-extracellular-signal-regulated kinase (p-ERK) and BRAFV600E was investigated. The results indicated that the mutation rate of BRAFV600E was 5.2% in CRC. Poorly differentiated tumors and mucinous tumors have a significantly higher incidence of BRAFV600E compared with well-differentiated tumors and non-mucinous tumors (P<0.05). Kaplan-Meier survival analysis indicated that the survival rate was markedly lower in patients with BRAFV600E compared with in patients with wild-type BRAF (BRAFWT). The expression of p-ERK and Mps1 in CRC with BRAFV600E was significantly higher compared with in CRC with BRAFWT (P<0.05), and their expression is associated with cancer classification, degree of differentiation and lymph node transfusion (P<0.05). In addition p-ERK expression was positively correlated with Mps1 expression, with a contingency coefficient of 0.679 (P=0.002). In conclusion, the results of the present study indicated that Mps1 was significantly associated with BRAFV600E/p-ERK and may serve a crucial function in the development of CRC. The results of the present study raise the possibility that targeting the oncogenic BRAF and Mps1, particularly when in conjunction, could provide promising therapeutic opportunities for the treatment of CRC. [ABSTRACT FROM AUTHOR]

Published
2019

49. Mps1 is associated with the BRAFV600E mutation but does not rely on the classic RAS/RAF/MEK/ERK signaling pathway in thyroid carcinoma.

Author

Li, Yike, Zhang, Yanyan, Xiao, Shuaishuai, Kong, PENgzhou, ChENg, Caixia, Shi, Ruyi, Wang, Fang, Zhang, Ling, Wang, Juan, Jia, Zhiwu, Wu, Shuai, Liu, Yun, Guo, JianshENg, ChENg, Xiaolong, Cui, Yongping, and Liu, Jing

Subjects
THYROID cancer, CARCINOMA, SERINE/THREONINE kinases, CHROMOSOMES, IMMUNOHISTOCHEMISTRY
Abstract

In previous studies, the B‑Raf proto‑oncogene, serine/threonine kinase (BRAF)V600E mutation has been identified in multiple malignant tumors. BRAFV600E has been revealed to contribute to tumorigenesis by the activation of phospho‑mitogen‑activated protein kinases (MAPKs) and their downstream Monopolar spindle 1 (Mps1), leading to chromosome euploidy and tumor development. In the present study, the presence of phospho‑MAPK and Mps1 in 161 thyroid carcinoma cases with complete clinical parameters was analyzed by immunohistochemistry, and the BRAF mutation was detected by polymerase chain reaction‑direct sequencing. It was revealed that BRAFV600E was present in ~34% of thyroid cancer cases and was associated with age, clinical tumor stage and lymph node stage. However, the association of BRAFV600E with overall survival was not statistically significant. The expression of Mps1 was significantly increased in tumor tissues with BRAFV600E, however, this did not affect the expression of phospho‑MAPK in thyroid carcinomas. Collectively, the results of the present study suggested that BRAFV600E may regulate the expression of Mps1 in MAP kinase independent ways in thyroid carcinoma. Therefore, Mps1 expression is associated with BRAFV600E while the upstream signaling of phospho‑MAPK has no relevance. The specific mechanisms of BRAFV600E and the unknown pathway associated with Mps1 exhibit potential for further study, and provide a theoretical basis for the molecular treatment of thyroid carcinoma. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

50. Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma

Author

Cheng, Caixia, primary, Cui, Heyang, additional, Zhang, Ling, additional, Jia, Zhiwu, additional, Song, Bin, additional, Wang, Fang, additional, Li, Yaoping, additional, Liu, Jing, additional, Kong, Pengzhou, additional, Shi, Ruyi, additional, Bi, Yanghui, additional, Yang, Bin, additional, Wang, Juan, additional, Zhao, Zhenxiang, additional, Zhang, Yanyan, additional, Hu, Xiaoling, additional, Yang, Jie, additional, He, Chanting, additional, Zhao, Zhiping, additional, Wang, Jinfen, additional, Xi, Yanfeng, additional, Xu, Enwei, additional, Li, Guodong, additional, Guo, Shiping, additional, Chen, Yunqing, additional, Yang, Xiaofeng, additional, Chen, Xing, additional, Liang, Jianfang, additional, Guo, Jiansheng, additional, Cheng, Xiaolong, additional, Wang, Chuangui, additional, Zhan, Qimin, additional, and Cui, Yongping, additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results