Search

Your search keyword '"Kong, Moonkyoo"' showing total 193 results
Start Over Author "Kong, Moonkyoo"
193 results on '"Kong, Moonkyoo"'

1. Clinically conserved genomic subtypes of gastric adenocarcinoma

Author

Jeong, Yun Seong, Eun, Young-Gyu, Lee, Sung Hwan, Kang, Sang-Hee, Yim, Sun Young, Kim, Eui Hyun, Noh, Joo Kyung, Sohn, Bo Hwa, Woo, Seon Rang, Kong, Moonkyoo, Nam, Deok Hwa, Jang, Hee-Jin, Lee, Hyun-Sung, Song, Shumei, Oh, Sang Cheul, Lee, Jeeyun, Ajani, Jaffer A., and Lee, Ju-Seog

Published
2023
Full Text
View/download PDF

9. A Survey Study on the Perception for Development of Integrated Medical Service Model and Its Application in Clinical Field - A Survey study with Doctors and Korean Medicine Doctors -

Author

Seo, Sangwoo, primary, Kim, Hyungsuk, additional, Lee, Seung Hyeun, additional, Kong, Moonkyoo, additional, Lee, Beom-Joon, additional, Heo, Sung Hyuk, additional, Kwon, Seung-won, additional, Park, Bong Jin, additional, Yun, Dong Hwan, additional, Lee, Euiju, additional, Oh, Hyunjoo, additional, Kim, Sung-Bum, additional, Choi, Hye-Sook, additional, Kim, Kwan-Il, additional, and Chung, Won-Seok, additional

Published
2023
Full Text
View/download PDF

12. Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma

Author

LEE, MIN KYEONG, NOH, JOO KYUNG, WOO, SEON RANG, KONG, MOONKYOO, LEE, YOUNG CHAN, LEE, JUNG WOO, KO, SEONG-GYU, and EUN, YOUNG-GYU

Subjects
Cancer Research, Carcinogenesis, Squamous Cell Carcinoma of Head and Neck, Ubiquitin-Protein Ligases, Prognosis, Biochemistry, Baculoviral IAP Repeat-Containing 3 Protein, Inhibitor of Apoptosis Proteins, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Biomarkers, Tumor, Genetics, Humans, Molecular Biology, Research Article, Signal Transduction
Abstract

Background/Aim: Head and neck squamous cell carcinoma (HNSCC) has poor prognosis, with survival rates that have not significantly improved over the past several decades. Therefore, prediction of HNSCC prognosis is of clinical importance. Baculoviral IAP Repeat containing 2 (BIRC2) and Baculoviral IAP Repeat containing 3 (BIRC3) are involved in oncogenic activity by modulating cell proliferation, apoptosis and invasion in HNSCC. This study aimed to develop and validate a predictive gene signature for BIRC2 and BIRC3. Materials and Methods: The genomic copy number and gene expression for BIRC2 and BIRC3 were systematically explored in patients with HNSCC to investigate the clinical relevance of BIRC2 and BIRC3 activation. A prognostic signature was developed based on correlations associated with BIRC2 and BIRC3 mRNA expression and copy number alterations. Hierarchical clustering was used to classify the clusters (Clusters 1 and 2). Moreover, independent validation of the BIRC2-BIRC3 gene signature was performed using the Leipzig, MDACC, FHCRC, and KHU datasets. To explore the biological functions of the BIRC2-BIRC3 gene signature, string analysis and pathway annotation were also performed. Results: BIRC2-BIRC3 gene signature-derived cluster 2 patients exhibited significantly poor survival. This signature also predicted survival in three independent cohorts. Interestingly, the BIRC2-BIRC3 gene signature additionally permitted the identification of survival in advanced tumor stages with excellent accuracy in all three cohorts. Multivariate Cox regression analysis identified that the BIRC2-BIRC3 signature was an independent predictor associated with the survival of patients with HNSCC. Moreover, Inhibition of BIRC2 modulated the NF-ĸB signaling pathway via upregulation of CBR1 expression. Conclusion: The BIRC2-BIRC3 gene signature was found to be associated with the prognosis of HNSCC. Thus, BIRC2 and BIRC3 could be potential targets for improving HNSCC prognosis.

Published
2022

16. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: role in apoptosis induction and radiosensitization in head and neck tumor cells

Author

Baek, Seung Ho, Ko, Jeong-Hyeon, Lee, Hanwool, Jung, Jinhong, Kong, Moonkyoo, Lee, Jung-woo, Lee, Junhee, Chinnathambi, Arunachalam, Zayed, M.E., Alharbi, Sulaiman Ali, Lee, Seok-Geun, Shim, Bum Sang, Sethi, Gautam, Kim, Sung-Hoon, Yang, Woong Mo, Um, Jae-Young, and Ahn, Kwang Seok

Subjects
Squamous cell carcinoma -- Genetic aspects -- Care and treatment -- Research, Cellular signal transduction -- Physiological aspects -- Genetic aspects -- Research, Resveratrol -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health, Science and technology
Abstract

ABSTRACT Background: Signal transducer and activator of transcription 3 (STAT3) is persistently activated in squamous cell carcinoma of the head and neck (SCCHN) and can cause uncontrolled cellular proliferation and [...]

Published
2016
Full Text
View/download PDF

22. Additional file 2 of Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

Author

Kim, Su Il, Woo, Seon Rang, Noh, Joo Kyung, Lee, Min Kyeong, Lee, Young Chan, Lee, Jung Woo, Kong, Moonkyoo, Ko, Seong-Gyu, and Eun, Young-Gyu

Abstract

Additional file 2: Supplementary Figure 2. Construction of the prediction model. (a) Venn diagram showing CSC gene expression signatures correlated with the four CSC genes – CD44, MET, ALDH1A1, and BMI1. (b) Schematic overview of the strategy used for constructing the prediction models and evaluating the predicted outcomes based on the CSC gene expression signatures.

Published
2022
Full Text
View/download PDF

23. Additional file 3 of Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

Author

Kim, Su Il, Woo, Seon Rang, Noh, Joo Kyung, Lee, Min Kyeong, Lee, Young Chan, Lee, Jung Woo, Kong, Moonkyoo, Ko, Seong-Gyu, and Eun, Young-Gyu

Abstract

Additional file 3: Supplementary Figure 3. Kaplan–Meier and ROC analyses for OS of all patients in the five independent cohorts. All patients were classified into CSC-HR and CSC-LR subgroups using the 81 CSC gene expression signatures. (a) Kaplan–Meier plots showing significant difference in the OS rates between the two groups (p

Published
2022
Full Text
View/download PDF

24. Additional file 1 of Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

Author

Kim, Su Il, Woo, Seon Rang, Noh, Joo Kyung, Lee, Min Kyeong, Lee, Young Chan, Lee, Jung Woo, Kong, Moonkyoo, Ko, Seong-Gyu, and Eun, Young-Gyu

Abstract

Additional file 1: Supplementary Figure 1. The prognosis according to the mRNA expression of each CSC gene in TCGA cohort. Cut-off values for continuous mRNA expression values were selected while referring to the ROC curve analysis. Kaplan–Meier plots showing the 5-year OS or RFS rates between the two subgroups based on the cut-off values of each CSC gene in TCGA cohort were depicted. Log-rank test was used to compare the prognosis of the two subgroups for each gene, and the plots with the lower p-value between plots depicting the 5-year OS and RFS for each gene were then selected. (a-d) CD44, MET, ALDH1A1, and BMI1 showed significant differences in the OS or RFS rates between the two subgroups classified according to the mRNA expression in TCGA cohort (p=0.0069, 0.0051, 0.028, and 0.021, respectively). (e-g) There were no significant differences in the OS or RFS rates between the two subgroups classified according to the mRNA expression of PROM1, SOX2, and POU5F1 in TCGA cohort (p=0.11, 0.097, and 0.12, respectively). *p

Published
2022
Full Text
View/download PDF

25. Additional file 4 of Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

Author

Kim, Su Il, Woo, Seon Rang, Noh, Joo Kyung, Lee, Min Kyeong, Lee, Young Chan, Lee, Jung Woo, Kong, Moonkyoo, Ko, Seong-Gyu, and Eun, Young-Gyu

Abstract

Additional file 4: Supplementary Table 1. Eighty-one CSC gene expression signatures in TCGA HNSCC cohort. Supplementary Table 2. Univariate and multivariate analyses of the characteristics associated with overall survival in patients with non-oropharyngeal cases in the four independent HNSCC cohorts (n=816). Supplementary Table 3. A total of 8 significant KEGG pathways associated with CSC gene expression signatures.

Published
2022
Full Text
View/download PDF

26. Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation.

Author

Noh, Joo Kyung, Woo, Seon Rang, Kong, Moonkyoo, Lee, Min Kyeong, Lee, Jung Woo, Lee, Young Chan, Ko, Seong‐Gyu, and Eun, Young‐Gyu

Abstract

Although numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these approaches has not been assessed clinically. Further, the mechanism underlying malignant behaviors in OSCC is poorly characterized. This study aimed to develop and verify accurate prognostic predictors for OSCC patients and assess the associated biology. We identified an OSCC‐recurrence‐related gene signature (ORGS) using a Cox regression analysis. Functional enrichment analysis was used to identify enriched pathways and biological processes to reveal the underlying mechanism of OSCC malignant behavior. The ORGS successfully divided OSCC patients into low‐ and high‐risk groups with significantly different overall survivals. Pathway analysis revealed oxidative phosphorylation (OXPHOS) as a signaling pathway associated with the ORGS in OSCC. Interestingly, high OXPHOS status was strongly associated with poor overall survival in OSCC patients. Mediator complex subunit 30 (MED30) was a predicted upstream regulator of OXPHOS, and knockdown of MED30 reduced histone acetylation. We identified that the ORGS was strongly correlated with OXPHOS regulatory processes, suggesting OXPHOS as a key mechanism leading to poor prognosis in OSCC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. Reactive Oxygen Species Modulator 1 is Associated with Poor Survival in Patients with Non-Small Cell Lung Cancer After Stereotactic Fractionated Radiosurgery: A Retrospective Pilot Study

Author

Kong,Moonkyoo, Sung,Ji-Youn, Lee,Seung Hyeun, Kong,Moonkyoo, Sung,Ji-Youn, and Lee,Seung Hyeun

Abstract

Moonkyoo Kong,1 Ji-Youn Sung,2 Seung Hyeun Lee3 1Division of Lung & Head and Neck Oncology, Department of Radiation Oncology, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea; 2Department of Pathology, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of KoreaCorrespondence: Seung Hyeun LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 23 Kyungheedae-Gil, Dongdaemoon-Gu, Seoul 02447, Republic of KoreaTel +82-2-958-8511Fax +82-2-958-2848Email humanmd04@daum.netPurpose: It has been reported that the overexpression of reactive oxygen species modulator 1 (Romo1) is significantly associated with poor survival outcomes in patients with lung cancer who received surgical resection, conventional fractionated radiotherapy, and chemotherapy. In this study, we investigated whether Romo1 expression is associated with survival outcomes in patients with early-stage lung cancer who were treated with radiosurgery.Methods: Romo1 protein expression was evaluated and scored in the tumor tissue specimens of 40 patients with non-small cell lung cancer by immunohistochemistry. An optimal cut-off for Romo1 expression was determined and used to allocate patients to low or high Romo1 expression groups. Survival outcomes were compared between the two groups.Results: Romo1 expression was significantly associated with distant metastasis-free survival. The 1- and 2-year distant metastasis-free survival rates were 96.4% and 92.6% in the low Romo1 expression group and 87.5% and 46.7% in the high Romo1 expression group (P=0.041), respectively. The overall, local recurrence-free, regional recurr

Published
2020

32. Characterization of compact alumina vacuum sealed x-ray tube for medical imaging: interpretation with simulation program

Author

Choi, Jinho, primary, Gupta, Amar P., additional, Jang, Jaekyu, additional, Yeo, Seung Jun, additional, Jung, Jaeik, additional, Chae, Moon Shik, additional, Yeon, Yeong Heum, additional, Lee, Byeong-No, additional, Oh, Kyungmin, additional, Ahn, Jeung Sun, additional, Kim, Seung Hoon, additional, Mok, Hyung-Soo, additional, Kong, Moonkyoo, additional, and Ryu, Jehwang, additional

Published
2021
Full Text
View/download PDF

36. Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer’s Disease

Author

Kim, Sujin, primary, Chung, Hyunju, additional, Ngoc Mai, Han, additional, Nam, Yunkwon, additional, Shin, Soo Jung, additional, Park, Yong Ho, additional, Chung, Mi Joo, additional, Lee, Jong Kil, additional, Rhee, Hak Young, additional, Jahng, Geon-Ho, additional, Kim, Youngkyong, additional, Lim, Yu Jin, additional, Kong, Moonkyoo, additional, Moon, Minho, additional, and Chung, Weon Kuu, additional

Published
2020
Full Text
View/download PDF

40. Reactive Oxygen Species Modulator 1 As An Adverse Prognostic Marker In Stage III Non-Small Cell Lung Cancer Treated With Radiotherapy: A Retrospective Pilot Study

Author

Kong,Moonkyoo, Sung,Ji-Youn, Lee,Seung Hyeun, Kong,Moonkyoo, Sung,Ji-Youn, and Lee,Seung Hyeun

Abstract

Moonkyoo Kong,1 Ji-Youn Sung,2 Seung Hyeun Lee3 1Division of Lung & Head and Neck Oncology, Department of Radiation Oncology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Republic of Korea; 2Department of Pathology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Republic of Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Republic of KoreaCorrespondence: Seung Hyeun LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University School of Medicine, Kyungheedae-ro 23, Dongdaemun-gu, Seoul 02447, Republic of KoreaTel +82 2 958 8511Fax +82 2 968 1848Email v3mann@naver.comPurpose: Reactive oxygen species modulator 1 (ROMO1) is a novel protein regulating intracellular reactive oxygen species production. Although increased ROMO1 expression has been associated with poor clinical outcomes in several human malignancies, the clinical implication of this protein in a radiotherapy setting has never been explored. The aim of this study was to investigate whether ROMO1 expression is associated with survival in lung cancer patients who received radiotherapy.Methods: ROMO1 protein expression was evaluated immunohistochemically using histologic score (H-score) in 49 tumor tissues from stage III non-small cell lung cancer (NSCLC) patients treated with definitive radiotherapy. We performed survival analyses according to various clinicopathological parameters including ROMO1 expression.Results: ROMO1 expression was not associated with any clinicopathological parameter of age, sex, smoking status, stage, or histological subtype. Multivariate analyses showed that high ROMO1 expression was independently associated with worse progression-free survival (hazard ratio [HR] = 1.87, 95% confidence interval [CI]: 1.02–4.23) and with w

Published
2019

44. PHYSICAL ACTIVITY CAN BOOST EMOTIONAL QUALITY OF LIFE IN BREAST CANCER SURVIVORS: SUB-SET ANALYSES OF KROG 14-09 NATIONWIDE QUESTIONNAIRE STUDY

Author

Sup Yoon, Won, primary, Ahn, Sung-Ja, primary, Hee Kim, Jin, primary, Chun, Mison, primary, Hong Rim, Chai, primary, Sik Yang, Dae, primary, Lee, Jong-Hoon, primary, Kong, Moonkyoo, primary, Kim, Suzy, primary, Kim, Juree, primary, Kim, Kyubo, primary, Ran Park, Kyung, primary, Shin, Young-Joo, primary, Young Ma, Sun, primary, Jeong, Bae-Kwon, primary, Ssan Kim, Su, primary, and Bae Kim, Yong, primary

Published
2019
Full Text
View/download PDF

46. Design and Fabrication of CNT-Based E-Gun Using Stripe-Patterned Alloy Substrate for X-Ray Applications.

Author

Lim, Jongmin, Gupta, Amar P., Yeo, Seung Jun, Kong, Moonkyoo, Cho, Chong-Gil, Kim, Seung Hoon, Ahn, Jeung Sun, Mativenga, Mallory, and Ryu, Jehwang

Subjects
X-rays, FIELD emission, ALLOYS, ELECTRON gun, X-ray imaging
Abstract

We report the enhancement of carbon nanotube (CNT) field emitters by growing them directly on stripe-patterned alloy substrates. For a gate voltage of 1300 V, CNT field emitters grown on full and stripe-patterned alloy substrates achieved respective emission currents of 0.22 and 2.32 mA, corresponding to tenfold performance enhancement. Performance enhancement is attributed to the reduced screening effect (as a result of the spacing between strips) during field emission and a damage-free patterning process. To verify the ability of the stripe-patterned CNT field emitters to generate X-rays, we designed and assembled an electron gun through brazing. With the open type X-ray system, an X-ray image of human teeth was successfully obtained, verifying the potential of the stipe-patterned CNT emitters in X-ray applications. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

47. Questionnaire study of the dietary habits of breast cancer survivors and their relationship to quality of life (KROG 14-09)

Author

Rim, Chai Hong, primary, Ahn, Sung-Ja, additional, Kim, Jin Hee, additional, Yoon, Won Sup, additional, Chun, Mison, additional, Yang, Dae Sik, additional, Lee, Jong-Hoon, additional, Kim, Kyubo, additional, Kong, Moonkyoo, additional, Kim, Suzy, additional, Kim, Juree, additional, Park, Kyung Ran, additional, Shin, Young-Joo, additional, Ma, Sun Young, additional, Jeong, Bae-Kwon, additional, Kim, Su Ssan, additional, Kim, Yong Bae, additional, Lee, Dong Soo, additional, and Cha, Jaehyung, additional

Published
2018
Full Text
View/download PDF

50. An assessment of quality of life for early phase after adjuvant radiotherapy in breast cancer survivors: a Korean multicenter survey (KROG 14–09)

Author

Rim, Chai Hong, primary, Ahn, Sung-Ja, additional, Kim, Jin Hee, additional, Yoon, Won Sup, additional, Chun, Mison, additional, Yang, Dae Sik, additional, Lee, Jong-Hoon, additional, Kim, Kyubo, additional, Kong, Moonkyoo, additional, Kim, Suzy, additional, Kim, Juree, additional, Park, Kyung Ran, additional, Shin, Young-Joo, additional, Ma, Sun Young, additional, Jeong, Bae-Kwon, additional, Kim, Su Ssan, additional, Kim, Yong Bae, additional, Lee, Dong Soo, additional, and Cha, Jaehyung, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results