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3. The J bs-5YP peptide can alleviate dementia in senile mice by restoring the transcription of Slc40a1 to secrete the excessive iron from brain

Author

Zou, Zhenyou, Wu, Fengyao, Chen, Liguan, Yao, Hua, Wang, Zengxian, Chen, Yongfeng, Qi, Ming, Jiang, Yang, Tang, Longhua, Gan, Xinying, Kong, Lingjia, Yang, Zhicheng, Huang, Xiaolan, Shu, Wei, Li, Bixue, Tan, Xinyu, Huang, Liwen, Bai, Shi, Wu, Lijuan, Mo, Jinping, Hu, Huilin, Liu, Huihua, Zou, Ruyi, and Wei, Yuhua

Published
2024
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12. The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer’s disease

Author

Zou, Zhenyou, Shen, Qiqiong, Pang, Yanxia, Li, Xin, Chen, Yongfeng, Wang, Xinjuan, Luo, Xinhua, Wu, Zhongmin, Bao, Zhaosheng, Zhang, Juanli, Liang, Jiawei, Kong, Lingjia, Yan, Lunan, Xiong, Lijun, Zhu, Tianjun, Yuan, Shuaibin, Wang, Miaoyang, Cai, Kewei, Yao, Yinning, Wu, Jianchao, Jiang, Yuding, Liu, Heng, Liu, Jing, Zhou, Yan, Dong, Qianqian, Wang, Wei, Zhu, Kangjie, Li, Li, Lou, Yingjie, Wang, Hongdian, Li, Yizi, and Lin, Hong

Published
2019
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13. Study of the Repellent Activity of 60 Essential Oils and Their Main Constituents against Aedes albopictus, and Nano-Formulation Development

Author

Wu, Weifeng, primary, Yang, Yu, additional, Feng, Yingmiao, additional, Ren, Xiaofei, additional, Li, Yuling, additional, Li, Wenjiao, additional, Huang, Jietong, additional, Kong, Lingjia, additional, Chen, Xiaole, additional, Lin, Zhongze, additional, Hou, Xiaohui, additional, Zhang, Longlai, additional, Chen, Yajie, additional, Sheng, Zhaojun, additional, and Hong, Weiqian, additional

Published
2022
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16. Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults

Author

Chou, Chih‐Hung, primary, Mohanty, Subhasis, additional, Kang, Heather A., additional, Kong, Lingjia, additional, Avila‐Pacheco, Julian, additional, Joshi, Samit R., additional, Ueda, Ikuyo, additional, Devine, Lesley, additional, Raddassi, Khadir, additional, Pierce, Kerry, additional, Jeanfavre, Sarah, additional, Bullock, Kevin, additional, Meng, Hailong, additional, Clish, Clary, additional, Santori, Fabio R., additional, Shaw, Albert C., additional, and Xavier, Ramnik J., additional

Published
2022
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18. Larvicidal Activity of Two Rutaceae Plant Essential Oils and Their Constituents Against Aedes albopictus (Diptera: Culicidae) in Multiple Formulations

Author

Jian, Rongchao, primary, Lin, Yuan, additional, Li, Yuling, additional, Wu, Weifeng, additional, Ren, Xiaofei, additional, Liang, Zhanyuan, additional, Kong, Lingjia, additional, Cai, Jinglin, additional, Lao, Canyao, additional, Wu, Min, additional, Chen, Wenhua, additional, Chen, Jing, additional, Hong, Weiqian David, additional, and Sheng, Zhaojun, additional

Published
2022
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20. Larvicidal Activity of Two RutaceaePlant Essential Oils and Their Constituents Against Aedes albopictus(Diptera: Culicidae) in Multiple Formulations

Author

Jian, Rongchao, Lin, Yuan, Li, Yuling, Wu, Weifeng, Ren, Xiaofei, Liang, Zhanyuan, Kong, Lingjia, Cai, Jinglin, Lao, Canyao, Wu, Min, Chen, Wenhua, Chen, Jing, Hong, Weiqian David, and Sheng, Zhaojun

Abstract

Aedes albopictus(Skuse) is a vector of several arboviruses, such as dengue, chikungunya, West Nile, and Zika viruses. At present, the use of synthetic insecticides is the main vector control strategy. However, the widespread and long-term use of insecticides has aroused several problems, including insecticide resistance, environmental pollution, and non-target species effects, thereby encouraging researchers to search for new alternatives derived from natural products. In recent decades, essential oils (EOs) as natural alternatives to control mosquitoes have received increasing attention. In the initial larvicidal activity screen, two Rutaceaeplants (Citrus aurantiumand Citrus paradisi) EOs were selected and evaluated for killing Ae. albopictuslarvae. The LC50values of C. aurantiumand C. paradisiEOs against Ae. albopictuswere 91.7 and 100.9 ppm, respectively. The main components of C. aurantiumEO include diethyl o-phthalate (37.32%), limonene (10.04%), and methyl dihydrojasmonate (6.48%). The main components of C. paradisiEO include limonene (60.51%), diethyl o-phthalate (11.75%), linalool (7.90%), and styralyl acetate (6.28%). Among these main components of the two EOs, limonene showed potent larvicidal activity, with the LC50value of 39.7 ppm. The nanoemulsions of limonene were prepared and characterized. The duration of larvicidal activity was greater in the limonene nanoemulsions than when limonene was applied in solvent. This study demonstrates that EOs of plants in family Rutaceaeare a potential resource to develop new larvicides, and nanoemulsification is an effective method for improving the physicochemical properties and efficacy of natural products as larvicides.

Published
2022
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23. The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer’s disease

Author

Zou, Zhenyou, primary, Shen, Qiqiong, additional, Pang, Yanxia, additional, Li, Xin, additional, Chen, Yongfeng, additional, Wang, Xinjuan, additional, Luo, Xinhua, additional, Wu, Zhongmin, additional, Bao, Zhaosheng, additional, Zhang, Juanli, additional, Liang, Jiawei, additional, Kong, Lingjia, additional, Yan, Lunan, additional, Xiong, Lijun, additional, Zhu, Tianjun, additional, Yuan, Shuaibin, additional, Wang, Miaoyang, additional, Cai, Kewei, additional, Yao, Yinning, additional, Wu, Jianchao, additional, Jiang, Yuding, additional, Liu, Heng, additional, Liu, Jing, additional, Zhou, Yan, additional, Dong, Qianqian, additional, Wang, Wei, additional, Zhu, Kangjie, additional, Li, Li, additional, Lou, Yingjie, additional, Wang, Hongdian, additional, Li, Yizi, additional, and Lin, Hong, additional

Published
2018
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24. An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets

Author

Domsgen, Erna, Lind, Katharina, Kong, Lingjia, Hühn, Michael H, Rasool, Omid, van Kuppeveld, Frank, Korsgren, Olle, Lahesmaa, Riitta, Flodström-Tullberg, Malin, dI&I I&I-1, Infection & Immunity, dI&I I&I-1, Infection & Immunity, BioMediTech - BioMediTech, and University of Tampere

Subjects
0301 basic medicine, Adult, Male, Risk, Interferon-Induced Helicase, IFIH1, Genotype, endocrine system diseases, Biolääketieteet - Biomedicine, Coxsackievirus Infections, Autoimmunity, Coxsackievirus, medicine.disease_cause, ta3111, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Islets of Langerhans, 0302 clinical medicine, Interferon, medicine, Humans, Genetic Predisposition to Disease, Alleles, Aged, Autoimmune disease, Multidisciplinary, biology, Effector, Pancreatic islets, ta1184, Immunology in the medical area, MDA5, Middle Aged, medicine.disease, biology.organism_classification, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Immunologi inom det medicinska området, 030220 oncology & carcinogenesis, Immunology, Female, Interferons, medicine.drug, Interferon Regulatory Factor-1
Abstract

The IFIH1 gene encodes the pattern recognition receptor MDA5. A common polymorphism in IFIH1 (rs1990760, A946T) confers increased risk for autoimmune disease, including type 1-diabetes (T1D). Coxsackievirus infections are linked to T1D and cause beta-cell damage in vitro. Here we demonstrate that the rs1990760 polymorphism regulates the interferon (IFN) signature expressed by human pancreatic islets following Coxsackievirus infection. A strong IFN signature was associated with high expression of IFNλ1 and IFNλ2, linking rs1990760 to the expression of type III IFNs. In the high-responding genotype, IRF-1 expression correlated with that of type III IFN, suggesting a positive-feedback on type III IFN transcription. In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D. It also highlights a previously unrecognized connection between the rs1990760 polymorphism and the expression level of type III IFNs.

Published
2016

25. An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets

Author

dI&I I&I-1, Infection & Immunity, Domsgen, Erna, Lind, Katharina, Kong, Lingjia, Hühn, Michael H, Rasool, Omid, van Kuppeveld, Frank, Korsgren, Olle, Lahesmaa, Riitta, Flodström-Tullberg, Malin, dI&I I&I-1, Infection & Immunity, Domsgen, Erna, Lind, Katharina, Kong, Lingjia, Hühn, Michael H, Rasool, Omid, van Kuppeveld, Frank, Korsgren, Olle, Lahesmaa, Riitta, and Flodström-Tullberg, Malin

Published
2016

27. Characterization of candidate genes in inflammatory bowel disease–associated risk loci

Author

Peloquin, Joanna M., primary, Goel, Gautam, additional, Kong, Lingjia, additional, Huang, Hailiang, additional, Haritunians, Talin, additional, Sartor, R. Balfour, additional, Daly, Mark J., additional, Newberry, Rodney D., additional, McGovern, Dermot P., additional, Yajnik, Vijay, additional, Lira, Sergio A., additional, and Xavier, Ramnik J., additional

Published
2016
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33. ESTOOLS Data@Hand: human stem cell gene expression resource

Author

Kong, Lingjia, primary, Aho, Kaisa-Leena, additional, Granberg, Kirsi, additional, Lund, Riikka, additional, Järvenpää, Laura, additional, Seppälä, Janne, additional, Gokhale, Paul, additional, Leinonen, Kalle, additional, Hahne, Lauri, additional, Mäkelä, Jarno, additional, Laurila, Kirsti, additional, Pukkila, Heidi, additional, Närvä, Elisa, additional, Yli-Harja, Olli, additional, Andrews, Peter W, additional, Nykter, Matti, additional, Lahesmaa, Riitta, additional, Roos, Christophe, additional, and Autio, Reija, additional

Published
2013
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36. High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Author

Närvä, Elisa, primary, Autio, Reija, additional, Rahkonen, Nelly, additional, Kong, Lingjia, additional, Harrison, Neil, additional, Kitsberg, Danny, additional, Borghese, Lodovica, additional, Itskovitz-Eldor, Joseph, additional, Rasool, Omid, additional, Dvorak, Petr, additional, Hovatta, Outi, additional, Otonkoski, Timo, additional, Tuuri, Timo, additional, Cui, Wei, additional, Brüstle, Oliver, additional, Baker, Duncan, additional, Maltby, Edna, additional, Moore, Harry D, additional, Benvenisty, Nissim, additional, Andrews, Peter W, additional, Yli-Harja, Olli, additional, and Lahesmaa, Riitta, additional

Published
2010
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37. Constitutively active autophagy dampens inflammation through metabolic and post-transcriptional regulation of macrophage cytokine production

Author

Xu, Jinjin, Kong, Lingjia, Oliver, Blayne A., Li, Bihua, Creasey, Elizabeth A., Guzman, Gaelen, Schenone, Monica, Carey, Kimberly L., Carr, Steven A., Graham, Daniel B., Deguine, Jacques, and Xavier, Ramnik J.

Abstract

Autophagy is an essential cellular process that is deeply integrated with innate immune signaling; however, studies that examine the impact of autophagic modulation in the context of inflammatory conditions are lacking. Here, using mice with a constitutively active variant of the autophagy gene Beclin1, we show that increased autophagy dampens cytokine production during a model of macrophage activation syndrome and in adherent-invasive Escherichia coli(AIEC) infection. Moreover, loss of functional autophagy through conditional deletion of Beclin1in myeloid cells significantly enhances innate immunity in these contexts. We further analyzed primary macrophages from these animals with a combination of transcriptomics and proteomics to identify mechanistic targets downstream of autophagy. Our study reveals glutamine/glutathione metabolism and the RNF128/TBK1 axis as independent regulators of inflammation. Altogether, our work highlights increased autophagic flux as a potential approach to reduce inflammation and defines independent mechanistic cascades involved in this control.

Published
2023
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38. Draft genome sequence of ectomycorrhizal edible mushroom Phlebopus portentosus strain YAF023.

Author

Yang M, Yuan X, Kong L, Gao Y, Liu C, and Wang Y

Abstract

Phlebopus portentosus is a favorite ectomycorrhizal edible mushroom in tropical China. Here, we present a draft genome sequence of P. portentosus strain YAF023. The genome resource will support subsequent research into the relationship between ectomycorrhizal fungi and trees., Competing Interests: The authors declare no conflict of interest.

Published
2024
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39. A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells.

Author

Ulezko Antonova A, Lonardi S, Monti M, Missale F, Fan C, Coates ML, Bugatti M, Jaeger N, Fernandes Rodrigues P, Brioschi S, Trsan T, Fachi JL, Nguyen KM, Nunley RM, Moratto D, Zini S, Kong L, Deguine J, Peeples ME, Xavier RJ, Clatworthy MR, Wang T, Cella M, Vermi W, and Colonna M

Subjects
Humans, Mice, Animals, Nuclear Receptor Subfamily 1, Group F, Member 3 metabolism, Inflammation metabolism, Dendritic Cells, Lymphocytes, Immunity, Innate
Abstract

Recent studies have characterized various mouse antigen-presenting cells (APCs) expressing the lymphoid-lineage transcription factor RORγt (Retinoid-related orphan receptor gamma t), which exhibit distinct phenotypic features and are implicated in the induction of peripheral regulatory T cells (Tregs) and immune tolerance to microbiota and self-antigens. These APCs encompass Janus cells and Thetis cell subsets, some of which express the AutoImmune REgulator (AIRE). RORγt + MHCII + type 3 innate lymphoid cells (ILC3) have also been implicated in the instruction of microbiota-specific Tregs. While RORγt + APCs have been actively investigated in mice, the identity and function of these cell subsets in humans remain elusive. Herein, we identify a rare subset of RORγt + cells with dendritic cell (DC) features through integrated single-cell RNA sequencing and single-cell ATAC sequencing. These cells, which we term RORγt + DC-like cells (R-DC-like), exhibit DC morphology, express the MHC class II machinery, and are distinct from all previously reported DC and ILC3 subsets, but share transcriptional and epigenetic similarities with DC2 and ILC3. We have developed procedures to isolate and expand them in vitro, enabling their functional characterization. R-DC-like cells proliferate in vitro, continue to express RORγt, and differentiate into CD1c + DC2-like cells. They stimulate the proliferation of allogeneic T cells. The identification of human R-DC-like cells with proliferative potential and plasticity toward CD1c + DC2-like cells will prompt further investigation into their impact on immune homeostasis, inflammation, and autoimmunity., Competing Interests: Competing interests statement:The authors declare no competing interest.

Published
2023
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40. An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Author

Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, Korsgren O, Lahesmaa R, and Flodström-Tullberg M

Subjects
Adult, Aged, Alleles, Diabetes Mellitus, Type 1 genetics, Diabetes Mellitus, Type 1 virology, Female, Genotype, Humans, Interferon Regulatory Factor-1 genetics, Interferons genetics, Male, Middle Aged, Risk, Autoimmunity genetics, Coxsackievirus Infections genetics, Genetic Predisposition to Disease genetics, Interferon-Induced Helicase, IFIH1 genetics, Islets of Langerhans metabolism, Polymorphism, Single Nucleotide genetics
Abstract

The IFIH1 gene encodes the pattern recognition receptor MDA5. A common polymorphism in IFIH1 (rs1990760, A946T) confers increased risk for autoimmune disease, including type 1-diabetes (T1D). Coxsackievirus infections are linked to T1D and cause beta-cell damage in vitro. Here we demonstrate that the rs1990760 polymorphism regulates the interferon (IFN) signature expressed by human pancreatic islets following Coxsackievirus infection. A strong IFN signature was associated with high expression of IFNλ1 and IFNλ2, linking rs1990760 to the expression of type III IFNs. In the high-responding genotype, IRF-1 expression correlated with that of type III IFN, suggesting a positive-feedback on type III IFN transcription. In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D. It also highlights a previously unrecognized connection between the rs1990760 polymorphism and the expression level of type III IFNs.

Published
2016
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