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4. Innervation der subperitonealen Beckenetage: Möglichkeiten zur Optimierung der Rektumchirurgie

Author

Clausen, N., Wolloscheck, T., Kneist, W., Paolucci, V., Konerding, M. A., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
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6. Some Problems of Trial Design for Anti-Angiogenic Agents in Cancer Therapy

Author

Arnold, Frank, Brem, H., Tamavokopulis, G., Tsakayannis, D., Gresser, I., Budson, A., Folkman, J., Cohen, Tzafra, Gitay-Goren, Hela, Neufeld, Gera, Levi, Ben Zion, Cherry, George, Eichman, Anne, Marcelle, Christophe, Bréant, Christiane, LeDouarin, Nicole M., Tran, Nam D., Wong, Vicky L. Y., Bready, James, Berliner, Judith, Fisher, Mark, Hadjiconti, O., Papaioannou, S., Haralabopoulos, G. C., Demopoulos, I., Maragoudakis, M. E., Haralabopoulos, George C., Tsopanoglou, Nikos E., Pipili-Synetos, Eva, Keshet, E., Shweiki, D., Bacharach, E., Itin, A., Banai, S., Konerding, M. A., van Ackern, C., Klapthor, B., Steinberg, F., Lehmann, M., Koolwijk, P., de Vree, W. J. A., Zurcher, C., van Hinsbergh, V. W. M., Krupinski, Jerzy, Kaluza, Jozef, Missirli, E., Bastaki, M., Karakiulakis, G., Morales, D. E., Grant, D. S., Maheshwari, S., Bhartiya, D., Cid, M. C., Kleinman, H. K., Schnaper, W. H., Papadimitriou, E., Unsworth, B. R., Lelkes, P. I., Rooney, P., Smith, I., Kumar, S., Stevens, Cliff, Harley, Suzanne, Marok, Rajdip, Sahinoglu, Tulin, Abbot, Stewart, Blake, David, Dougher-Vermazen, Maureen, Gospodarowicz, Denis, Terman, Bruce I., Maragoudakis, Michael E., editor, Gullino, Pietro M., editor, and Lelkes, Peter I., editor

Published
1994
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16. Verbesserte Nervenregeneration bei autologer Nerventransplantation durch VEGF-Gentherapie

Author

Giunta, R. E., Holzbach, T., Milojcic, R., Anton, M., Brill, T., Konerding, M. A., Gänsbacher, B., Machens, H. G., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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17. Magnetofektion von akustisch aktiven 'magnetic microspheres' (Magnetobubbles) — Induktion von Angiogenese durch non-virale Transfektion von VEGF

Author

Holzbach, T., Neshkova, I., Vlaskou, D., Konerding, M. A., Gänsbacher, B., Plank, C., Machens, H. G., Giunta, R. E., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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39. Sensitivität und Spezifität der Untersuchung spinale Traumen mittels Sonographie

Author

Meinig, H, Döffert, J, Gercek, E, Konerding, M, Ostrowski, G, and Pitzen, T

Subjects
Wirbelfrakturen Ultraschall Diagnostik Schockraummanagment, ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Die Indikation zur operative Versorgung von Verletzungen der Wirbelsäule ist abhängig von dem Ausmaß ihrer Zerstörung. Wesentlich dabei ist, ob neben einer ventralen Verletzung zusätzlich der dorsale Bandapparat zerstört ist. Dies ist beweisend für eine[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2012)

Published
2012
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40. Alternative Drittventrikulostomie durch endoskopische transventrikuläre Fensterung der Lamina terminalis

Author

Vulcu, S, Schroeder, H, Konerding, M, Gaab, MR, Wagner, W, and Oertel, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: In der Therapie des okklusiven Hydrozephalus ist die endoskopische Drittventrikulostomie zu den basalen Zisternen ein etabliertes Verfahren. In einigen Fällen ist die Fensterung des Bodens aufgrund von Verwachsungen, Membranen oder großen Blutgefäßen nicht möglich.[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
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41. Buchbesprechungen

Author

Henche, H. -R., Holder, J., Stuhler, T., Fiege, A., Rakofsky, M., Konerding, M. A., Hohenberger, W., Sattlar, H., Harland, U., Starche, D., Pfeil, E., Cotta, H., Braun, A., and Endo-Klinik Hamburg

Published
1989
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43. Impact of fibroblast growth factor-2 on tumor microvascular architecture. A tridimensional morphometric study

Author

Konerding, M. A., Fait, E., Dimitropoulou, C., Malkusch, W., Ferri, C., Giavazzi, R., Coltrini, D., and Marco PRESTA

Subjects
Microcirculation, Mice, Nude, Adenocarcinoma, Corrosion Casting, Transfection, Endometrial Neoplasms, Specific Pathogen-Free Organisms, Mice, Tumor Cells, Cultured, Animals, Humans, Female, Fibroblast Growth Factor 2, Neoplasm Transplantation, Research Article
Abstract

Three cell clones originated by transfection of human endometrial adenocarcinoma HEC-1-B cells with fibroblast growth factor-2 (FGF-2) cDNA and characterized by a different capacity to produce and secrete the growth factor were transplanted subcutaneously in nude mice. Corrosion casting of the tumor microvasculature of xenografts produced by injection of 2 x 10(6) or 10 x 10(6) FGF-2-B9 cells (which produce and secrete significant amounts of FGF-2), 10 x 10(6) FGF-2-A8 cells (which produce comparable amounts of FGF-2 but do not secrete it), or 10 x 10(6) control FGF-2-B8 cells (which produce only trace amounts of FGF-2) was performed after 14 days of growth. Interbranching distances, intervascular distances, branching angles, and vessel diameters were then determined using tridimensional stereo pairs of the casted tumor vascularity. When transplanted at the same concentration, FGF-2-B9 cells grew faster in nude mice compared with FGF-2-A8 and FGF-2-B8 clones. The total amount of new vessel formation was far higher in FGF-2-B9 tumors than in FGF-2-B8 or FGF-2-A8 tumors. Also, vessel courses were more irregular and blind-ending vessels and evasates were more frequent in FGF-2-B9 tumors. Moreover, FGF-2-B9 tumor microvasculature was characterized by a wider average vascular diameter and by an extreme variability of the diameter of each individual vessel along its course between two ramifications. No statistical differences were observed when the distribution curves of the values of intervascular distances, interbranching distances, and branching angles of the microvessel network were compared among the different experimental groups. The distinctive features of the microvasculature of FGF-2-B9 tumors were retained, at least in part, in the smaller lesions produced by injection of a limited number of cells. The data indicate that FGF-2 production and release confer to FGF-2-B9 cells the ability to stimulate the formation of new blood vessels with distinctive architectural features. Neovascularization of FGF-2-B9 lesions parallels the faster rate of growth of the neoplastic parenchyma. This does not affect the overall architecture of the microvessel network that appears to be primed by characteristics of the HEC-1-B tumor cell line and/or by the microenvironment of the host. To our knowledge, this work represents the first attempt to define the influence of a single, defined growth factor on the tridimensional tumor vascular pattern.

Published
1998

44. LOP32

Author

Heit, Y. I., primary, Lancerotto, L., additional, Cortes, R., additional, Mesteri, I., additional, Ackermann, M., additional, Hollander, R., additional, Li, Q., additional, Konerding, M. A., additional, and Orgill, D. P., additional

Published
2013
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47. Impact of the Incubation Medium on the Endothelium of Autologous Vein Grafts: Damage Scoring by Scanning Electron Microscopy

Author

Konerding, M. A., Knocks, M., and Zerkowski, H. -R.

Subjects
cardioplegic solutions, Bretschneider’s HTK, coronary artery bypass grafting, Endothelium, Ringer’s solution, organ preservation, Biology, heparinized whole blood, scanning electron microscopy
Abstract

The aim of this study was to examine the influence of different incubation media on the morphology of the endothelium of great saphenous vein grafts and establish a suitable scoring system for the evaluation of damage caused by these media. Fifty specimens of saphenous veins from ten patients during elective aorto-coronary bypass surgery were used. Ten specimens served as controls; the others were assigned to test groups and exposed to heparinized whole blood, Bretschneider's HTK, human albumin or Ringer's solution. Specimens exposed to heparinized blood showed only slight morphological alterations, whereas the other three mediums caused severe damage. Thus, heparinized blood seems to be most suitable as a rinsing and incubation medium. A widely accepted scoring system for the quantification of endothelial damage caused by the incubation media did not adequately reflect the morphological alterations in the cytoskeleton and membrane topology. The proposed scoring system, which is based on endothelial cell separation, endothelial cell loss, amount of deposits, endothelial cell surface homogeneity, in addition to the frequency of spikes and blebs, seems to be suitable for characterizing differences in endothelial morphology.

Published
1996

48. Microvascular Corrosion Casting in the Study of Tumor Vascularity: A Review

Author

Konerding, M. A., Miodonski, A. J., and Lametschwandtner, A.

Subjects
experimental tumor, Microvascular corrosion casting, tumor vascularization, xenotransplantation, tumor angiogenesis, vascular architecture, sprout formation, neovascularization, Biology, network formation, scanning electron microscopy
Abstract

Tumor blood flow is dependent on the structure and three-dimensional (3-D) architecture of the vascular network. The latter can be best studied by scanning electron microscopy of microvascular corrosion casts. However, literature reviews show that nearly all studies using this technique render comparisons of different tumors more difficult since they are mainly based on descriptive terms that might lead to misunderstandings. Qualitative comparisons of 13 experimental and 3 human primary tumors of different origin show a high degree of similarity in the vasculature. Quantitative analysis of these casts reveals similar ranges of parameters such as diameters, intervascular and interbranching distances. Diameters of vessels with capillary wall structure range from 6 μm to 55 μm in the human primary tumors (renal clear cell carcinoma, basalioma), and from 5 μm to 80 μm in xenografted tumors (sarcomas, colon carcinoma). Intervascular distances in the human primary tumors range from 2 μm to 52 μm, and from 11 μm to 105 μm in the xenografts. Interbranching distances range from 34 μm to 258 μmin the former, and from 11 μm to 160 μmin the latter. Both qualitative and quantitative analyses of tumor microvascular corrosion casts enable pathophysiological conclusions to be drawn and contribute to a better understanding of tumor vascularity.

Published
1995

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