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122 results on '"Koneracka, Martina"'

2. Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use

Author

Mirković, Marija, Milanović, Zorana, Perić, Marko, Vranješ-Đurić, Sanja, Ognjanović, Miloš, Antić, Bratislav, Kuraica, Milorad, Krstić, Ivan, Kubovcikova, Martina, Antal, Iryna, Sobotova, Radka, Zavisova, Vlasta, Jurikova, Alena, Fabian, Martin, and Koneracka, Martina

Published
2022
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6. Low magnetic field induced capacitance changes in ferronematics

Author

Tomašovičová, Natália, Timko, Milan, Mitróová, Zuzana, Koneracká, Martina, Rajňak, Michal, Éber, Nándor, Tóth-Katona, Tibor, Chaud, Xavier, Jadzyn, Jan, and Kopčanský, Peter

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science
Abstract

The response in capacitance to low external magnetic fields (up to 0.1 T) of suspensions of spherical magnetic nanoparticles, single-wall carbon nanotubes (SWCNT), SWCNT functionalized with carboxyl group (SWCNT-COOH) and SWCNT functionalized with Fe$_3$O$_4$ nanoparticles in a nematic liquid crystal has been studied experimentally. The volume concentration of nanoparticles was $\phi_1$ = 10$^{-4}$ and $\phi_2$ = 10$^{-3}$. Independent of the type and the volume concentration of the nanoparticles, a linear response to low magnetic fields (far below the magnetic Fr\'eederiksz transition threshold) has been observed, which is not present in the undoped nematic.

Published
2014
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7. Magnetic Fluids and Their Complex Systems

Author

Kopcansky, Peter, Timko, Milan, Koneracka, Martina, Zavisova, Vlasta, Kubovcikova, Martina, Molcan, Matus, Balejcikova, Lucia, Tomasovicova, Natalia, Rajnak, Michal, Gdovinova, Veronika, Bulavin, Leonid A., editor, and Chalyi, Alexander V., editor

Published
2018
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8. Radiation stability of biocompatibile magnetic fluid

Author

Tomasovicova, Natalia, Haysak, Ivan, Koneracka, Martina, Kovac, Jozef, Timko, Milan, Zavisova, Vlasta, Okunev, Alexander, Parlag, Alexander, Fradkin, Alexey, and Kopcansky, Peter

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

The radiation stability of biocompatibile magnetic fluid used in nanomedicine after electron irradiation was studied. Two types of the water-based magnetic fluids were prepared. The first one was based on the magnetite nanoparticles stabilized by one surfactant natrium oleate. The second one was biocompatibile magnetic fluid stabilized with two surfactants, natrium oleate as a first surfactant and Poly(ethylene glycol) (PEG) as a second surfactant. The magnetization measurements showed that electron irradiation up to 1000Gy caused 50% reduction of saturation magnetization in the case of the first sample with only one surfactant while in the case of the second biocompatibile magnetic fluid, only 25% reduction of saturation magnetization was observed. In the first magnetic fluid the radiation caused the higher sedimentation of the magnetic particles than in the second case, when magnetic particles are covered also with PEG. The obtained results show that PEG behave as a protective element., Comment: 15 pages, 8 figures

Published
2010

9. N-Acetylcysteine-Loaded Magnetic Nanoparticles for Magnetic Resonance Imaging

Author

Kubovcikova, Martina, primary, Sobotova, Radka, additional, Zavisova, Vlasta, additional, Antal, Iryna, additional, Khmara, Iryna, additional, Lisnichuk, Maksym, additional, Bednarikova, Zuzana, additional, Jurikova, Alena, additional, Strbak, Oliver, additional, Vojtova, Jana, additional, Mikolka, Pavol, additional, Gombos, Jan, additional, Lokajova, Alica, additional, Gazova, Zuzana, additional, and Koneracka, Martina, additional

Published
2023
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11. Magnetic Fluids and Their Complex Systems

Author

Kopcansky, Peter, primary, Timko, Milan, additional, Koneracka, Martina, additional, Zavisova, Vlasta, additional, Kubovcikova, Martina, additional, Molcan, Matus, additional, Balejcikova, Lucia, additional, Tomasovicova, Natalia, additional, Rajnak, Michal, additional, and Gdovinova, Veronika, additional

Published
2017
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13. Numerical Modeling of Nanoparticles Tracking in the Blood Stream

Author

Val’ová, Lucia, Jadlovský, Ján, Streltsova, Oxana, Kopčanský, Peter, Timko, Milan, Kubovčíková, Martina, Koneracká, Martina, Závišová, Vlasta, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Adam, Gheorghe, editor, Buša, Ján, editor, and Hnatič, Michal, editor

Published
2012
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14. Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use

Author

Mirković, Marija D., Milanović, Zorana, Perić, Marko R., Vranješ-Đurić, Sanja, Ognjanović, Miloš, Antić, Bratislav, Kuraica, Milorad, Krstić, Ivan, Kubovcikova, Martina, Antal, Iryna, Sobotova, Radka, Zavisova, Vlasta, Jurikova, Alena, Fabian, Martin, Koneracka, Martina, Mirković, Marija D., Milanović, Zorana, Perić, Marko R., Vranješ-Đurić, Sanja, Ognjanović, Miloš, Antić, Bratislav, Kuraica, Milorad, Krstić, Ivan, Kubovcikova, Martina, Antal, Iryna, Sobotova, Radka, Zavisova, Vlasta, Jurikova, Alena, Fabian, Martin, and Koneracka, Martina

Abstract

Surface modification of magnetic nanoparticles with poly-L-lysine, proline, and tryptophan was used to design potential theranostic agents for the application in cancer diagnosis and radionuclide-hyperthermia therapy. Characterization of bare and functionalized magnetic nanoparticles was performed in detail. The transparency of the examined magnetic nanoparticles was measured in the non-alternating magnetic field for a complete and better understanding of hyperthermia. For the first time amino acid-functionalized magnetic nanoparticles were labeled with theranostic radionuclides 131I and 177Lu. The specific absorption rate (SAR) procured for poly-L-lysine functionalized magnetic nanoparticles (SAR values of 99.7 W/g at H0 = 15.9 kA/m and resonant frequency of 252 kHz) demonstrated their possible application in magnetic hyperthermia. Poly-L-lysine functionalized magnetic nanoparticles labeled with 177Lu showed the highest radiochemical purity (>99.00 %) and in vitro stability in saline and serum (>98.00 % up to 96 h). The in vivo analysis performed after their intravenous administration in healthy Wistar rats presented good in vivo stability for several days. Encouraging results as well as magnetic and radiochemical properties of 177Lu–PLL-MNPs (80 °C) justify their further testing toward the potential use as theranostic agents for diagnostic and combined radionuclide-hyperthermia therapeutic applications.

Published
2022

16. Design and Preparation of Proline, Tryptophan and Poly-L-Lysine Functionalized Magnetic Nanoparticles and Their Radiolabeling with 131i and 177lu for Potential Theranostic Use

Author

Mirković, Marija, primary, Milanović, Zorana, additional, Perić, Marko, additional, Vranješ-Đurić, Sanja, additional, Ognjanović, Miloš, additional, Antić, Bratislav, additional, Krstić, Ivan, additional, Kuraica, Milorad, additional, Kubovcikova, Martina, additional, Antal, Iryna, additional, Sobotova, Radka, additional, Zavisova, Vlasta, additional, Jurikova, Alena, additional, Fabian, Martin, additional, and Koneracka, Martina, additional

Published
2022
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17. Combined Therapy with Simvastatin- and Coenzyme-Q10-Loaded Nanoparticles Upregulates the Akt-eNOS Pathway in Experimental Metabolic Syndrome.

Author

Şaman, Ezgi, Cebova, Martina, Barta, Andrej, Koneracka, Martina, Zavisova, Vlasta, Eckstein-Andicsova, Anita, Danko, Martin, Mosnacek, Jaroslav, and Pechanova, Olga

Subjects
SIMVASTATIN, UBIQUINONES, NICOTINAMIDE adenine dinucleotide phosphate, METABOLIC syndrome, NITRIC-oxide synthases, LABORATORY rats, NADPH oxidase
Abstract

In addition to their LDL-cholesterol-lowering effect, statins have pleiotropic beneficial effects on the cardiovascular system. However, long-term treatment with statins may be associated with serious side effects. With the aim to make statin therapy more effective, we studied the effects of simvastatin- and coenzyme-Q10-loaded polymeric nanoparticles on the lipid profile and nitric oxide (NO)/reactive oxygen species (ROS) balance in the heart and aorta of adult male obese Zucker rats. The rats were divided into an untreated group, a group treated with empty nanoparticles, and groups treated with simvastatin-, coenzyme Q10 (CoQ10)-, or a combination of simvastatin- and CoQ10-loaded nanoparticles (SIMV+CoQ10). After 6 weeks, the lipid profile in the plasma and the concentration of conjugated dienes in the liver were determined. Nitric oxide synthase (NOS) activity, Akt, endothelial NOS (eNOS), phosphorylated eNOS (p-eNOS), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and nuclear factor kappaB (NF-kappaB) protein expressions were measured in the heart and aorta. All simvastatin, CoQ10, and SIMV+CoQ10 treatments decreased plasma LDL levels, but only the combined SIMV+CoQ10 treatment increased NOS activity and the expression of Akt, eNOS, and p-eNOS in both the heart and the aorta. Interestingly, NADPH oxidase in the heart and NF-kappaB protein expression in the aorta were decreased by all treatments, including nanoparticles alone. In conclusion, only combined therapy with SIMV- and CoQ10-loaded nanoparticles increased NOS activity and upregulated the Akt-eNOS pathway in obese Zucker rats, which may represent a promising tool for the treatment of cardiometabolic diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Targeting of carbonic anhydrase IX-positive cancer cells by glycine-coated superparamagnetic nanoparticles

Author

Antal, Iryna, primary, Koneracka, Martina, additional, Kubovcikova, Martina, additional, Zavisova, Vlasta, additional, Jurikova, Alena, additional, Khmara, Iryna, additional, Omastova, Maria, additional, Micusik, Matej, additional, Barathova, Monika, additional, Jelenska, Lenka, additional, Kajanova, Ivana, additional, Zatovicova, Miriam, additional, and Pastorekova, Silvia, additional

Published
2021
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25. Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

Author

Strbak, Oliver, primary, Antal, Iryna, additional, Khmara, Iryna, additional, Koneracka, Martina, additional, Kubovcikova, Martina, additional, Zavisova, Vlasta, additional, Molcan, Matus, additional, Jurikova, Alena, additional, Hnilicova, Petra, additional, Gombos, Jan, additional, Kadasova, Nina, additional, and Dobrota, Dusan, additional

Published
2020
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33. Effect of magnetic nanoparticles coating on cell proliferation and uptake

Author

Zavišova, Vlasta, Koneracka, Martina, Gabelova, Alena, Svitkova, Barbora, Ursinyova, Monika, Kubovčikova, Martina, Antal, Iryna, Khmara, Iryna, Jurikova, Alena, Molčan, Matuš, Ognjanović, Miloš, Antić, Bratislav, Kopčansky, Peter, Zavišova, Vlasta, Koneracka, Martina, Gabelova, Alena, Svitkova, Barbora, Ursinyova, Monika, Kubovčikova, Martina, Antal, Iryna, Khmara, Iryna, Jurikova, Alena, Molčan, Matuš, Ognjanović, Miloš, Antić, Bratislav, and Kopčansky, Peter

Abstract

Magnetic iron oxide nanoparticles (MNPs) are one of the most promising types of nanoparticles for biomedical applications, primarily in the context of nanomedicine-based diagnostics and therapy. They are used as contrast agents in magnetic resonance imaging and magnetite cell labelling. Furthermore, they are promising heating mediator in magnetic hyperthermia-based therapy, and can serve as nanocarriers in targeted gene and drug delivery as well. In biomedical applications, coating plays an important role in nanoparticle dispersion stability and biocompatibility. However, the impact of nanoparticle surface chemistry on cell uptake and proliferation has not been sufficiently investigated. The objective of this study is to prepare magnetic nanoparticles with inner magnetite core and hydrophilic outer shell of surfactant, protein and polymers that are commonly used in biomedical research. MNPs were characterized in-depth by various physicochemical methods. Magnetic hyperthermia, applied to find out the influence of MNPs coating on heating characteristics of the samples, did not show any correlation between layer thickness and specific adsorption rate. To evaluate the impact of surface chemistry on cell proliferation and internalization, the human lung adenocarcinoma epithelial (A549) cells were utilized. Substantial differences were determined in the amount of internalized MNPs and cell viability in dependence on surface coating. Our results indicate that the surface chemistry not only protects particles from agglomeration but also affect the interaction between cell and MNPs. © 2018 Elsevier B.V.

Published
2019

38. Effect of magnetic nanoparticles coating on cell proliferation and uptake

Author

Zavisova, Vlasta, primary, Koneracka, Martina, additional, Gabelova, Alena, additional, Svitkova, Barbora, additional, Ursinyova, Monika, additional, Kubovcikova, Martina, additional, Antal, Iryna, additional, Khmara, Iryna, additional, Jurikova, Alena, additional, Molcan, Matus, additional, Ognjanović, Miloš, additional, Antić, Bratislav, additional, and Kopcansky, Peter, additional

Published
2019
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40. d,l-lysine functionalized Fe3O4 nanoparticles for detection of cancer cells

Author

Antal, Iryna, primary, Koneracka, Martina, additional, Kubovcikova, Martina, additional, Zavisova, Vlasta, additional, Khmara, Iryna, additional, Lucanska, Dasa, additional, Jelenska, Lenka, additional, Vidlickova, Ivana, additional, Zatovicova, Miriam, additional, Pastorekova, Silvia, additional, Bugarova, Nikola, additional, Micusik, Matej, additional, Omastova, Maria, additional, and Kopcansky, Peter, additional

Published
2018
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42. Dielectric Spectroscopy of Ferronematics Based on 6CHBT Liquid Crystal

Author

Rajnak, Michal, primary, Kopcansky, Peter, additional, Gdovinova, Veronika, additional, Zavisova, Vlasta, additional, Antal, Iryna, additional, Kurimsky, Juraj, additional, Dolnik, Bystrik, additional, Jadzyn, Jan, additional, Tomasovicova, Natalia, additional, Koneracka, Martina, additional, and Timko, Milan, additional

Published
2015
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44. Magnetic poly(d,l-lactide) nanoparticles loaded with aliskiren: A promising tool for hypertension treatment

Author

Antal, Iryna, primary, Kubovcikova, Martina, additional, Zavisova, Vlasta, additional, Koneracka, Martina, additional, Pechanova, Olga, additional, Barta, Andrej, additional, Cebova, Martina, additional, Antal, Vitaliy, additional, Diko, Pavel, additional, Zduriencikova, Martina, additional, Pudlak, Michal, additional, and Kopcansky, Peter, additional

Published
2015
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50. Magnetic-Field Induced Isotropic to Nematic Phase Transition in Ferronematics

Author

Kopcansky, Peter, primary, Honkonen, Juha, additional, Beaugnon, Eric, additional, Chaud, Xavier, additional, Tomasovicova, Natália, additional, Koneracka, Martina, additional, Zavisova, Vlasta, additional, Timko, Milan, additional, Hnatic, Michal, additional, Eber, Nándor, additional, Toth-Katona, Tibor, additional, and Jadzyn, Jan, additional

Published
2011
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