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1,410 results on '"Kondo, Tadashi"'

9. Experimentally shock-induced melt veins in basalt: Improving the shock classification of eucrites

Author

Ono, Haruka, Kurosawa, Kosuke, Niihara, Takafumi, Mikouchi, Takashi, Tomioka, Naotaka, Isa, Junko, Kagi, Hiroyuki, Matsuzaki, Takuya, Sakuma, Hiroshi, Genda, Hidenori, Sakaiya, Tatsuhiro, Kondo, Tadashi, Kayama, Masahiro, Koike, Mizuho, Sano, Yuji, Murayama, Masafumi, Satake, Wataru, and Matsui, Takafumi

Subjects
Astrophysics - Earth and Planetary Astrophysics, Physics - Geophysics
Abstract

Basaltic rocks occur widely on the terrestrial planets and differentiated asteroids, including the asteroid 4 Vesta. We conducted a shock recovery experiment with decaying compressive pulses on a terrestrial basalt at Chiba Institute of Technology, Japan. The sample recorded a range of pressures, and shock physics modeling was conducted to add a pressure scale to the observed shock features. The shocked sample was examined by optical and electron microscopy, electron back-scattered diffractometry, and Raman spectroscopy. We found that localized melting occurs at a lower pressure (~10 GPa) than previously thought (>20 GPa). The shocked basalt near the epicenter represents shock degree C of a recently proposed classification scheme for basaltic eucrites and, as such, our results provide a pressure scale for the classification scheme. Finally, we estimated the total fraction of the basaltic eucrites classified as shock degree C to be ~15% by assuming the impact velocity distribution onto Vesta., Comment: 17 pages, 4 figures, 1 table, 1 supplementary Information, accepted for publication in Geophysical Research Letters

Published
2022
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11. Shock recovery with decaying compressive pulses: Shock effects in calcite (CaCO$_3$) around the Hugoniot elastic limit

Author

Kurosawa, Kosuke, Ono, Haruka, Niihara, Takafumi, Sakaiya, Tatsuhiro, Kondo, Tadashi, Tomioka, Naotaka, Mikouchi, Takashi, Genda, Hidenori, Matsuzaki, Takuya, Kayama, Masahiro, Koike, Mizuho, Sano, Yuji, Murayama, Masafumi, Satake, Wataru, and Matsui, Takafumi

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Geophysics
Abstract

Shock metamorphism of minerals in meteorites provides insights into the ancient Solar System. Calcite is an abundant aqueous alteration mineral in carbonaceous chondrites. Return samples from the asteroids Ryugu and Bennu are expected to contain calcite-group minerals. Although shock metamorphism in silicates has been well studied, such data for aqueous alteration minerals are limited. Here, we investigated the shock effects in calcite with marble using impact experiments at the Planetary Exploration Research Center of Chiba Institute of Technology. We produced decaying compressive pulses with a smaller projectile than the target. A metal container facilitates recovery of a sample that retains its pre-impact stratigraphy. We estimated the peak pressure distributions in the samples with the iSALE shock physics code. The capability of this method to produce shocked grains that have experienced different degrees of metamorphism from a single experiment is an advantage over conventional uniaxial shock recovery experiments. The shocked samples were investigated by polarizing microscopy and X-ray diffraction analysis. We found that more than half of calcite grains exhibit undulatory extinction when peak pressure exceeds 3 GPa. This shock pressure is one order of magnitude higher than the Hugoniot elastic limit (HEL) of marble, but it is close to the HEL of a calcite crystal, suggesting that the undulatory extinction records dislocation-induced plastic deformation in the crystal. Finally, we propose a strategy to re-construct the maximum depth of calcite grains in a meteorite parent body, if shocked calcite grains are identified in chondrites and/or return samples from Ryugu and Bennu., Comment: 25 pages, 9 figures, 1 table, 1 supporting information, accepted for publication in Journal of Geophysical Research Planets

Published
2022
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15. Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma

Author

Rasmussen, Samuel V., Wozniak, Agnieszka, Lathara, Melvin, Goldenberg, Joshua M., Samudio, Benjamin M., Bickford, Lissett R., Nagamori, Kiyo, Wright, Hollis, Woods, Andrew D., Chauhan, Shefali, Lee, Che-Jui, Rudzinski, Erin R., Swift, Michael K., Kondo, Tadashi, Fisher, David E., Imyanitov, Evgeny, Machado, Isidro, Llombart-Bosch, Antonio, Andrulis, Irene L., Gokgoz, Nalan, Wunder, Jay, Mirotaki, Hiroshi, Nakamura, Takuro, Srinivasa, Ganapati, Thway, Khin, Jones, Robin L., Huang, Paul H., Berlow, Noah E., Schöffski, Patrick, and Keller, Charles

Published
2023
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27. CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs

Author

Okimoto, Ross A, Wu, Wei, Nanjo, Shigeki, Olivas, Victor, Lin, Yone K, Ponce, Rovingaile Kriska, Oyama, Rieko, Kondo, Tadashi, and Bivona, Trever G

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biotechnology, Rare Diseases, Orphan Drug, Pediatric Research Initiative, Infectious Diseases, Genetics, Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Carcinogenesis, Cell Line, Tumor, Cyclin E, Cyclin-Dependent Kinase 2, Female, Humans, Mice, Mice, SCID, Neoplasm Metastasis, Neoplasms, Experimental, Oncogene Proteins, Oncogene Proteins, Fusion, Proto-Oncogene Proteins c-ets, Sarcoma, Transcription, Genetic, Molecular genetics, Oncology, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Transcription factor fusion genes create oncoproteins that drive oncogenesis and represent challenging therapeutic targets. Understanding the molecular targets by which such fusion oncoproteins promote malignancy offers an approach to develop rational treatment strategies to improve clinical outcomes. Capicua-double homeobox 4 (CIC-DUX4) is a transcription factor fusion oncoprotein that defines certain undifferentiated round cell sarcomas with high metastatic propensity and poor clinical outcomes. The molecular targets regulated by the CIC-DUX4 oncoprotein that promote this aggressive malignancy remain largely unknown. We demonstrated that increased expression of ETS variant 4 (ETV4) and cyclin E1 (CCNE1) occurs via neomorphic, direct effects of CIC-DUX4 and drives tumor metastasis and survival, respectively. We uncovered a molecular dependence on the CCNE-CDK2 cell cycle complex that renders CIC-DUX4-expressing tumors sensitive to inhibition of the CCNE-CDK2 complex, suggesting a therapeutic strategy for CIC-DUX4-expressing tumors. Our findings highlight a paradigm of functional diversification of transcriptional repertoires controlled by a genetically aberrant transcriptional regulator, with therapeutic implications.

Published
2019

39. Recovery of entire shocked samples in a range of pressure from ~100 GPa to Hugoniot Elastic Limit

Author

Nagaki, Keita, Kadono, Toshihiko, Sakaiya, Tatsuhiro, Kondo, Tadashi, Kurosawa, Kosuke, Hironaka, Yoichiro, Shigemori, Keisuke, and Arakawa, Masahiko

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We carried out laser shock experiments and wholly recovered shocked olivine and quartz samples. We investigated the petrographic features based on optical micrographs of sliced samples and found that each recovered sample comprises three regions, I (optically dark), II (opaque) and III (transparent). Scanning electron microscopy combined with electron back-scattered diffraction shows that there are no crystal features in the region I; the materials in the region I have once melted. Moreover, numerical calculations performed with the iSALE shock physics code suggest that the boundary between regions II and III corresponds to Hugoniot Elastic Limit (HEL). Thus, we succeeded in the recovery of the entire shocked samples experienced over a wide range of pressures from HEL (~ 10 GPa) to melting pressure (~ 100 GPa) in a hierarchical order., Comment: 53 pages, 11 figures, 4 tables, accepted for publication in Meteoritics and Planetary Science

Published
2016
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