Search

Shigekazu Kitamura,1 Noboru Imai,2 Yuka Tanji,3 Akichika Ozeki,3 Mika Komori3 1Department of Neurology, Konan Kakogawa Hospital, Hyogo, Japan; 2Department of Neurology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan; 3Japan Drug Development and Medical Affairs, Eli Lilly Japan K.K., Kobe, JapanCorrespondence: Mika Komori, Japan Drug Development and Medical Affairs, Eli Lilly Japan K.K., 5-1-28, Isogamidori, Chuo-Ku, Kobe-Shi, 651-0086, Japan, Tel +81-78-242-8391, Fax +81-78-242-9939, Email komori_mika@lilly.comBackground: Migraine is often comorbid with other disorders. People with migraine may be prescribed one or more concomitant medications. This post hoc analysis assessed the safety and efficacy of lasmiditan in Japanese people with migraine comorbidities or using concomitant medications.Patients and Methods: The MONONOFU study was a Phase 2, randomized, placebo-controlled, multicenter study of lasmiditan for acute migraine treatment in Japanese adults. Patients reported comorbidities (pre-existing or coexisting conditions) during screening. Concomitant medications (any drugs taken ± 48 hours of the study drug) and treatment-emergent adverse events (TEAEs) were recorded in a paper diary. Study drug efficacy (pain freedom 2 hours after administration of study drug) was reported in an eDiary. Logistic regression models were used for subgroup analyses of safety (incidence of TEAEs) and efficacy (pain freedom at 2 hours post dose) of lasmiditan in relation to presence/absence of comorbidities, and safety in relation to concomitant medications.Results: Common comorbidities (occurring in ≥ 10% of any lasmiditan dose group) were seasonal allergies, allergic rhinitis, tension-type headache, cervicobrachial syndrome, dysmenorrhea, nasopharyngitis, musculoskeletal stiffness, chronic gastritis, constipation, and insomnia. There was no significant interaction of treatment with comorbidity for safety or efficacy. There was also no significant interaction between treatment and concomitant medication groups of special interest (acetaminophen/nonsteroidal anti-inflammatory drugs, triptans, antiemetics, central nervous system depressant medications, serotonergic medications, antiepileptics, antihypertensive medications, Chinese herbal medicines, and contraceptives) for incidence of TEAEs.Conclusion: In Japanese people with migraine, the safety of lasmiditan appeared to be independent of common comorbidities and concomitant medications; efficacy appeared to be independent of comorbid conditions.Clinical Trials Registration: NCT03962738 (ClinicalTrials.gov).Keywords: comorbidity, drug therapy, headache, Japan, migraine disorders, safety

Introduction: We hypothesized that perioperative fibrinogen level, platelet count, and rotational thromboelastometry (ROTEM) data values decrease in proportion to cardiopulmonary bypass (CPB) time, particularly in patients who underwent deep hypothermic circulatory arrest (DHCA). Methods: A total of 160 patients were enrolled and divided into the following three groups depending on CPB time: <2-h, 2– 3-h, and >3-h groups. Blood samples were obtained during CPB weaning. Platelet count, ROTEM data, fibrinogen level, and antithrombin level were determined. For propensity matching, we selected 15 patients who underwent DHCA and 15 patients who did not undergo DHCA and used propensity scores to match CPB time and other characteristics. Results: The <2-h, 2–3-h, and >3-h groups included 74, 63, and 23 patients, respectively. No significant differences in platelet count and fibrinogen level were observed between the groups. Antithrombin level and amplitude of clot firmness at 10 min in the EXTEM and FIBTEM tests were lowest in the >3-h group. Similarly, blood loss volume and transfusion volume were highest in the >3-h group. Significant differences in platelet count, ROTEM data, lowest esophageal and bladder temperatures, and transfusion volume were observed between patients who underwent DHCA and patients who did not undergo DHCA. Conclusions: The longer the CPB time, the greater the perioperative blood loss volume and transfusion volume, particularly if CPB time is greater than 3 hours. Sub-group analysis revealed that DHCA affects perioperative platelet count and function as well as blood loss volume. [ABSTRACT FROM AUTHOR]

Clopidogrel is a widely prescribed prodrug with antithrombotic activity that functions by irreversibly inhibiting the P2Y12 receptors on platelets; nevertheless, drug-induced eosinophilia from this drug is rarely reported. An 81-year-old man was diagnosed with cerebral infarction 2 months earlier and was admitted to our hospital with rash, fever, wheezing, and stomach discomfort after being initiated with clopidogrel treatment. Based on his medical history, chest CT, and gastroscopy, we diagnosed him with clopidogrel-induced hypereosinophilic syndrome. After discontinuation of clopidogrel, the eosinophilia and symptoms improved. In cases of drug-induced eosinophilia, it is important to obtain a detailed medical history.

The use of a high Tc superconductor to improve a magnetically levitated stepping motor is reported.

Research describing a miniature flywheel energy storage system is presented. In particular the dynamics of hybrid magnetic bearings with H-infinity control methods are investigated.

Research describing the dynamics of passive superconducting magnetic bearings is presented. In particular the repulsive force and bearing stiffness in relation to the horizontal motion of a permanent magnet is investigated.

The static, dynamic and rotational performance of magnetic bearing systems consisting of two high-temperature superconducting bearings and a rotor were investigated. Specifically, three systems containing three different rotors were subjected to stability, rotation and spin-down tests of the rotors. The results, which showed the bearings' applicability as radial and thrust bearings, revealed that the first and second rotors remains stable when rotating at speeds up to 50,000 rpm.

Most patients with early SjS are asymptomatic or have non-specific symptoms such as fatigue, often taking considerable time to achieve a diagnosis of SjS with typical sicca symptoms. Learning Point for CliniciansSjögren's syndrome (SjS)-induced bronchus-associated lymphoid tissue (BALT) may be the cause of anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis and BALT lymphoma. Therefore, we speculate that SjS preceded the induction of BALT, led to the development of RA through ACPA production, and simultaneously progressed to BALT lymphoma. [Extracted from the article]