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1. Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Author

Akinyemi, Rufus O., Tiwari, Hemant K., Srinivasasainagendra, Vinodh, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Mamaeva, Olga A., Halloran, Brian A., Akinyemi, Joshua, Lackland, Daniel, Obiabo, Olugbo Y., Sunmonu, Taofik, Chukwuonye, Innocent I., Arulogun, Oyedunni, Jenkins, Carolyn, Adeoye, Abiodun, Agunloye, Atinuke, Ogah, Okechukwu S., Ogbole, Godwin, Fakunle, Adekunle, Uvere, Ezinne, Coker, Motunrayo M., Okekunle, Akinkunmi, Asowata, Osahon, Diala, Samuel, Ogunronbi, Mayowa, Adeleye, Osi, Laryea, Ruth, Tagge, Raelle, Adeniyi, Sunday, Adusei, Nathaniel, Oguike, Wisdom, Olowoyo, Paul, Adebajo, Olayinka, Olalere, Abimbola, Oladele, Olayinka, Yaria, Joseph, Fawale, Bimbo, Ibinaye, Philip, Oyinloye, Olalekan, Mensah, Yaw, Oladimeji, Omotola, Akpalu, Josephine, Calys-Tagoe, Benedict, Dambatta, Hamisu A., Ogunniyi, Adesola, Kalaria, Rajesh, Arnett, Donna, Rotimi, Charles, Ovbiagele, Bruce, and Owolabi, Mayowa O.

Published
2024
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2. A Simulation Study of Functional Electrical Stimulation for An Upper Limb Rehabilitation Robot using Iterative Learning Control (ILC) and Linear models

Author

Faremi, Boluwatife E., Ayodele, Kayode P., Jubril, Abimbola M., Fakunle, Afeez A., Olaogun, Mathew O. B., Fawale, Micheal B., and Komolafe, Morenikeji A.

Subjects
Computer Science - Robotics, Electrical Engineering and Systems Science - Systems and Control, I.2.6, I.2.9, I.6.3, J.7
Abstract

A proportional iterative learning control (P-ILC) for linear models of an existing hybrid stroke rehabilitation scheme is implemented for elbow extension/flexion during a rehabilitative task. Owing to transient error growth problem of P-ILC, a learning derivative constraint controller was included to ensure that the controlled system does not exceed a predefined velocity limit at every trial. To achieve this, linear transfer function models of the robot end-effector interaction with a stroke subject (plant) and muscle response to stimulation controllers were developed. A straight-line point-point trajectory of 0 - 0.3 m range served as the reference task space trajectory for the plant, feedforward, and feedback stimulation controllers. At each trial, a SAT-based bounded error derivative ILC algorithm served as the learning constraint controller. Three control configurations were developed and simulated. The system performance was evaluated using the root means square error (RMSE) and normalized RMSE. At different ILC gains over 16 iterations, a displacement error of 0.0060 m was obtained when control configurations were combined., Comment: 15 pages, 16 Figures

Published
2022
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3. Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study

Author

Okubadejo, Njideka, Ojo, Oluwadamilola, Abiodun, Oladunni, Achoru, Charles, Agabi, Osigwe, Agulanna, Uchechi, Akinyemi, Rufus, Ali, Mohammed, Ani-Osheku, Ifeyinwa, Arigbodi, Ohwotemu, Bello, Abiodun, Erameh, Cyril, Farombi, Temitope, Fawale, Michael, Imarhiagbe, Frank, Iwuozo, Emmanuel, Komolafe, Morenikeji, Nwani, Paul, Nwazor, Ernest, Nyandaiti, Yakub, Obiabo, Yahaya, Odeniyi, Olanike, Odiase, Francis, Ojini, Francis, Onwuegbuzie, Gerald, Osaigbovo, Godwin, Osemwegie, Nosakhare, Oshinaike, Olajumoke, Otubogun, Folajimi, Oyakhire, Shyngle, Ozomma, Simon, Samuel, Sarah, Taiwo, Funmilola, Wahab, Kolawole, Zubair, Yusuf, Gams Massi, Daniel, Gueumekane Bila lamou, Eric, Njamnshi Nfor, Leonard, Magnerou, Mélanie Annick, Fogang Fogoum, Yannick, Shalash, Ali, El-FawaI, Hassan, Khedr, Eman, Fawi, Gharib, A. Eltantawi, Mohamed, Salama, Mohamed, El-Jaafary, Shaimaa, Hamed, Sharifa, Tafesse Mengesha, Abenet, Alemayehu Ayele, Biniyam, Melka Oda, Dereje, Zenebe Zewde, Yared, Debebe Gelan, Yohanesse, AkpaIu, Albert, Charway-Felli, Augustina, Stephen Sarfo, Fred, Adjei, Patrick, Obese, Vida, Bocoum, Abdoulaye, Koita, Abdou, Oumar Guinto, Cheick, Coulibaly, Toumany, Maiga, Youssoufa, Kone, Zaynab, Bell, Abiodun, Adebowale, Akintunde A., Akpekpe, John, lyagba, Alagoma, Wulgo, Ali Mohammed, Arabambi, Babawale, Agu, Christian, Dike, Franklin, Ishola, Ismail, Abiodun, Kehinde, Ekenze, Oluchi, Agabi Osigwe, Paul, Balarabe, Salisu, Abubakar, Sani, Williams, Uduak, Fall, Maouly, Mamadou Diop, Alassane, Hilaire Dominique, Ewodo Touna, Mochan, Andre, Modi, Girish, Dindayal, Saiesha, Ali Awadelkareem, Eman, Elsayed, Inas, Dahawi, Maha, Awadelkareem, Mosab Ali, Misbah, Sarah, Mushengez, Brighton, Kimambo, Henrika, Msango, Leonard, Adebayo, Philip, OKeng, Kigocha, Diekker, Marieke, URassa, Sarah, Gouider, Riadh, Ben Djebara, Mouna, Gargouri, Amina, Kacem, Imen, Nasri, Amina, Mrabet, Saloua, Sghaier, Ikram, Mkada, Imen, Atadzhanov, Masharip, Chishimba, Lorraine, Rizig, Mie, Jama, Fatumah, Okunoye, Olaitan, Hardy, John, Houlden, Henry, Singleton, Andrew, Nalls, Mike, Shamim, Ejaz, Jonas, Cabell, Williamson, Jared, Hall, Deborah A., Rosenbaum, Marc, Davis, Staci, Dean, Marissa, Cromer, Candace, Smith, Jenna, Ruffrage, Lauren, Richardson, Joseph, Sipma, Rebeka, Xie, Tao, Padmanaban, Manesh, Warren, Natalie, Mercado, Tomas, Disbrow, Elizabeth, Chauppeta, Brian, Thomas-Dean, Fermine, Toms, Jamie, Lofton, Katelyn, Rawls, Ashley, Rizer, Kyle, Black, Nieci, Solle, Justin, O'Grady, Alyssa, Sherer, Todd, Fiske, Brian, Başak, A. Nazlı, Tan, Ai Huey, Noyce, Alastair, Akpalu, Albert, Espay, Alberto, Martínez-Carrasco, Alejandro, Medina, Alex, Zimprich, Alexander, Brice, Alexis, Karimova, Altynay, Hernandez, Alvaro, Illarionova, Anastasia, Quattrone, Andrea, Singleton, Andrew B, Sobering, Andrew K., Vinuela, Angel, Sanyaolu, Arinola, Schumacher-Schuh, Artur F., Kishore, Asha, Ahmad-Annuar, Azlina, Al Mubarak, Bashayer, Tang, Beisha, Pizarro Galleguillos, Benjamin, Jeon, Beomseok, Siddiqi, Bernadette, Casey, Bradford, Mollenhauer, Brit, Carroll, Camille, Rieder, Carlos, Pantazis, Caroline B., Comart, Charisse, Lin, Chin-Hsien, Klein, Christine, Bale, Claire, Shepherd, Claire E, Wegel, Claire, Blauwendraat, Cornelis, Vitale, Dan, Martinez-Ramirez, Daniel, Hall, Deborah, Hernandez, Dena, KP, Divya, Nguyen, Duan, Fon, Edward A., Dadiotis, Efthymios, Riley, Ekemini, Iakovenko, Elena, Stafford, Ellie, Gatto, Emilia M, Valente, Enza Maria, Vollstedt, Eva-Juliane, Faghri, Faraz, Genc, Gencer, Xiromerisiou, Georgia, Hadjigorgiou, Georgios, Hiu-Fai Chan, Germaine, Arboleda, Gonzalo, Kaishibayeva, Gulnaz, Höglinger, Günter, Leonard, Hampton, Madoev, Harutyun, Iwaki, Hirotaka, Chen, Honglei, Wu, Hsiu-Chuan, Shang, Huifang, Morris, Huw R, F. Mata, Ignacio, Keller Sarmiento, Ignacio Juan, Dagklis, Ioannis, Tarnanas, Ioannis, Aasly, Jan O., Hoenicka, Janet, Corvol, Jean-Christophe, Foo, Jia Nee, Guo, Jifeng, Junker, Johanna, Carr, Jonathan, Kim, Jonggeol Jeff, Orozco, Jorge, Jankovic, Joseph, Shulman, Joshua, Hunter, Julie, Solle, Justin C., Murphy, Kaileigh, Nuytemans, Karen, Kieburtz, Karl, Lohmann, Katja, Marek, Kenneth, Mok, Kin Ying, Kumar, Kishore, Levine, Kristin, Chahine, Lana M., Lange, Lara M., Pihlstrøm, Lasse, Screven, Laurel, Stefanis, Leonidas, Shulman, Lisa, Marsili, Luca, Parnetti, Lucilla, Kuhl, Maggie, Funayama, Manabu, Sharma, Manu, Tan, Manuela, Kauffman, Marcelo, Miranda, Marcelo, Bustamante, Maria Leonor, Stamelou, Maria, Periñan Tocino, Maria Teresa, Cornejo-Olivas, Mario, Jimenez del Rio, Marlene, Makarious, Mary B, Koretsky, Mathew, Rodriguez-Violante, Mayela, Ellis, Melina, Avenali, Micol, Rentería, Miguel E., Inca-Martines, Miguel z, Nalls, Mike A., Ibrahim Norlinah, Mohamed, Umair, Muhammad, Ip, Nancy, Louie, Naomi, Cheung, Nelson Yuk-Fai, Mencacci, Niccolò Emanuele, Wood, Nicholas, Williams, Nigel, Hattori, Nobutaka, Abdul Murad, Nor Azian, Ibrahim, Norlinah Mohamed, Monchi, Oury, Öztop Çakmak, Özgür, Öztop Çakmak, Patricio Öztop Çakmak, Lewis, Patrick Alfryn, Pastor, Pau, Reyes-Pérez, Paula, Saffie Awad, Paula, Chana, Pedro, Chan, Phillip, Kung, Pin-Jui, Chan, Piu, Pal, Pramod, Lingappa Kukkle, Prashanth, Ojha, Rajeev, Kaiyrzhanov, Rauan, Krüger, Rejko, Amouri, Rim, Weil, Rimona, Rajan, Roopa, Alcalay, Roy, Wu, Ruey-Meei, Borgohain, Rupam, Sassi, Samia Ben, Khachatryan, Samson, Bandres-Ciga, Sara, El-Sadig, Sarah, Wu, Serena, Groppa, Sergio, Azmin, Shahrul, Lim, Shen-Yang, Ur-Rehman, Shoaib, Ertan, Sibel, Stott, Simon, Jasaitye, Simona, Chowdhury, Sohini, Dumanis, Sonya, Bardien, Soraya, Lubbe, Steven, Koks, Sulev, Dey, Sumit, Foroud, Tatiana, Fon, Ted, Beach, Thomas, Gasser, Thomas, Anderson, Tim, Nguyen, Toan, Schirinzi, Tommaso, Shiraishi, Tomotaka, Pitcher, Toni, Tumas, Vitor, Mohamed, Wael, Kamel, Walaa A., Luo, Wei, Zhou, Xiaopu, Zewde, Yared Z., Song, Yeajin, Wen, Yi, Wu, Yihru, Joong Kim, Yun, Tavadyan, Zaruhi, Fang, Zih-Hua, Ojo, Oluwadamilola Omolara, Crea, Peter Wild, Abiodun, Oladunni Victoria, Levine, Kristin S, Abubakar, Sani Atta, Achoru, Charles Obiora, Adeniji, Olaleye Akinmola, Agabi, Osigwe Paul, Koretsky, Mathew J, Hall, Deborah A, Akinyemi, Rufus Olusola, Ali, Mohammed Wulgo, Shamim, Ejaz A, Padmanaban, Mahesh, Arigbodi, Ohwotemu Michael, Standaert, David G, Bello, Abiodun Hamzat, Dean, Marissa N, Erameh, Cyril Oshomah, Farombi, Temitope Hannah, Fawale, Michael Bimbola, Billingsley, Kimberley J, Imarhiagbe, Frank Aiwansoba, Jerez, Pilar Alvarez, Iwuozo, Emmanuel Uzodinma, Baker, Breeana, Komolafe, Morenikeji Adeyoyin, Malik, Laksh, Nwani, Paul Osemeke, Daida, Kensuke, Nwazor, Ernest Okwundu, Miano-Burkhardt, Abigail, Nyandaiti, Yakub Wilberforce, Obiabo, Yahaya Olugbo, Kluss, Jillian H, Odeniyi, Olanike Adedoyin, Hernandez, Dena G, Odiase, Francis Ehidiamen, Tayebi, Nahid, Ojini, Francis Ibe, Sidranksy, Ellen, Onwuegbuzie, Gerald Awele, D'Souza, Andrea M, Osaigbovo, Godwin Osawaru, Berhe, Bahafta, Reed, Xylena, Oshinaike, Olajumoke Olufemi, Leonard, Hampton L, Otubogun, Folajimi Morenikeji, Alvarado, Chelsea X, Oyakhire, Shyngle Imiewan, Ozomma, Simon Izuchukwu, Samuel, Sarah Chabiri, Taiwo, Funmilola Tolulope, Wahab, Kolawole Wasiu, Zubair, Yusuf Agboola, Kim, Jonggeol Jeffrey, Nalls, Mike A, Heilbron, Karl, Norcliffe-Kaufmann, Lucy, and Okubadejo, Njideka Ulunma

Published
2023
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5. Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage

Author

Komolafe, Morenikeji A., Sunmonu, Taofiki, Akinyemi, Joshua, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Owolabi, Lukman, Osaigbovo, Godwin O., Ogbole, Godwin, Tiwari, Hemant K., Jenkins, Carolyn, Lackland, Daniel T., Fakunle, Adekunle G., Uvere, Ezinne, Akpa, Onoja, Dambatta, Hamisu A., Akpalu, Josephine, Onasanya, Akinola, Olaleye, Adeniji, Ogah, Okechukwu S., Isah, Sulaiman Y., Fawale, Micheal B., Adebowale, Akintunde, Okekunle, Akinkunmi P., Arnett, Donna, Adeoye, Abiodun M., Agunloye, Atinuke M., Bello, Abiodun H., Aderibigbe, Adeniyi S., Idowu, Ahmed O., Sanusi, Ahmad A., Ogunmodede, Adebimpe, Balogun, Simon A., Egberongbe, Adedeji A., Rotimi, Folorunso T., Fredrick, Adeyemi, Akinnuoye, Andrew O., Adeniyi, Folu A., Calys-Tagoe, Benedict, Adebayo, Philip, Arulogun, Oyedunni, Agbogu-Ike, Obiageli U., Yaria, Joseph, Appiah, Lambert, Ibinaiye, Philip, Singh, Arti, Adeniyi, Sunday, Olalusi, Oladotun, Mande, Aliyu, Balogun, Olayemi, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa

Published
2024
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6. Current Practice of Sleep Medicine in Nigeria

Author

Komolafe, Morenikeji Adeyoyin, primary, Olorunmoteni, Oluwatosin Eunice, additional, Kolawole, Kikelomo Adebanke, additional, Ogundipe, Olufemi K., additional, Fawale, Michael Bimbola, additional, Adebowale, Akintunde Adeolu, additional, Idowu, Ahmed Omokayode, additional, Sanusi, Ahmad Abefe, additional, Eziyi, Josephine Eniola A., additional, and Mosaku, Kolawole Samuel, additional

Published
2023
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8. Patient-level and system-level determinants of stroke fatality across 16 large hospitals in Ghana and Nigeria: a prospective cohort study

Author

Sarfo, Fred S, Akpa, Onoja M, Ovbiagele, Bruce, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Ogbole, Godwin, Fakunle, Adekunle, Okekunle, Akinkunmi Paul, Asowata, Osahon J, Calys-Tagoe, Benedict, Uvere, Ezinne O, Sanni, Taofeek, Olowookere, Samuel, Ibinaiye, Philip, Akinyemi, Joshua O, Arulogun, Oyedunni, Jenkins, Carolyn, Lackland, Daniel T, Tiwari, Hemant K, Isah, Suleiman Y, Abubakar, Sani A, Oladimeji, Adebayo, Adebayo, Philip, Akpalu, Josephine, Onyeonoro, Ugochukwu, Ogunmodede, James A, Akisanya, Cynthia, Mensah, Yaw, Oyinloye, Olalekan I, Appiah, Lambert, Agunloye, Atinuke M, Osaigbovo, Godwin O, Adeoye, Abiodun M, Adeleye, Osimhiarherhuo Ohifemen, Laryea, Ruth Y, Olunuga, Taiwo, Ogah, Okechukwu S, Oguike, Wisdom, Ogunronbi, Mayowa, Adeniyi, Wasiu, Olugbo, Obiabo Y, Bello, Abiodun H, Ogunjimi, Luqman, Diala, Samuel, Dambatta, Hamisu A, Singh, Arti, Adamu, Sheila, Obese, Vida, Adusei, Nathaniel, Owusu, Dorcas, Ampofo, Michael, Tagge, Raelle, Fawale, Bimbo, Yaria, Joseph, Akinyemi, Rufus O, and Owolabi, Mayowa O

Published
2023
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9. Are there differences in perceptions, preferences and attitudes towards disclosure of genetic testing for Stroke? A qualitative study among stroke-free SIREN-SIBS genomics study participants

Author

Arulogun, Oyedunni, Nichols, Michelle, Jenkins, Carolyn, Fakunle, Adekunle Gregory, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Okekunle, Akinkunmi Paul, Akinyemi, Joshua, Ogbole, Godwin, Calys-Tagoe, Benedict, Adeleye, Adeniji, Mensah, Yaw, Asowata, Osahon Jeffery, Adeoye, Abiodun M., Appiah, Lambert, Singh, Arti, Adebayo, Philip, Arnett, Donna, Tiwari, Hemant K., Lackland, Daniel, Ibinaiye, Philip, Oguike, Wisdom, Melikam, Chimdinma, Sunday, Adeniyi, Bello, Abiodun, Ogah, Okechukwu, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa

Published
2023
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10. Differential associations between pre-diabetes, diabetes and stroke occurrence among West Africans

Author

Sarfo, Fred Stephen, Ovbiagele, Bruce, Akinyemi, Joshua, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Ogbole, Godwin, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin, Jenkins, Carolyn, Fakunle, Adekunle, Adeoye, Abiodun, Lackland, Dan, Arnett, Donna, Tiwari, Hemant K., Olunuga, Taiwo, Uvere, Ezinne, Fawale, Bimbo, Ogah, Okechukwu, Agunloye, Atinuke, Faniyan, Moyinoluwalogo, Diala, Samuel, Yinka, Oladele, Laryea, Ruth, Osimhiarherhuo, Adeleye, Akinsanya, Cynthia, Abdulwasiu, Adeniyi, Akpalu, Josephine, Arulogun, Oyedunni, Appiah, Lambert, Dambatta, Hamisu, Olayemi, Balogun, Onasanya, Akinola, Isah, Sulaiman, Akinyemi, Rufus, and Owolabi, Mayowa

Published
2022
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11. Determinants of metabolic syndrome and its prognostic implications among stroke patients in Africa: Findings from the Stroke Investigative Research and Educational Network (SIREN) study

Author

Adeoye, Abiodun M., Akintunde, Adeseye A., Akinyemi, Joshua, Fakunle, Adekunle G., Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Akpa, Onoja, Arulogun, Oyedunni, Okekunle, Akinkunmi P., Ogah, Okechukwu S., Jenkins, Carolyn, Ogbole, Godwin, Tiwari, Hemant K., Asowata, Osahon J., Ibinaiye, Philip, Appiah, Lambert, Agunloye, Atinuke M., Yaria, Joseph, Calys-Tagoe, Benedict, Agbogu-Ike, Obiageli U., Adeniyi, Sunday, Adebayo, Philip, Balogun, Olayemi, Aderonmu, Olajumoke, Adeegbe, Oluwayemisi T., Adebayo, Oladimeji, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa

Published
2022
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13. APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s disease

Author

Okubadejo, Njideka U., Okunoye, Olaitan, Ojo, Oluwadamilola O., Arabambi, Babawale, Akinyemi, Rufus O., Osaigbovo, Godwin O., Abubakar, Sani A., Iwuozo, Emmanuel U., Wahab, Kolawole W., Agabi, Osigwe P., Agulanna, Uchechi, Imarhiagbe, Frank A., Abiodun, Oladunni V., Achoru, Charles O., Adebowale, Akintunde A., Adeniji, Olaleye, Akpekpe, John E., Ali, Mohammed W., Ani-Osheku, Ifeyinwa, Arigbodi, Ohwotemu, Balarabe, Salisu A., Bello, Abiodun H., Ekenze, Oluchi S., Erameh, Cyril O., Farombi, Temitope H., Fawale, Michael B., Komolafe, Morenikeji A., Nwani, Paul O., Nwazor, Ernest O., Nyandaiti, Yakub, Obehighe, Emmanuel E., Obiabo, Yahaya O., Odeniyi, Olanike A., Odiase, Francis E., Ojini, Francis I., Onwuegbuzie, Gerald A., Osemwegie, Nosakhare, Oshinaike, Olajumoke O., Otubogun, Folajimi M., Oyakhire, Shyngle I., Taiwo, Funlola T., Williams, Uduak E., Ozomma, Simon, Zubair, Yusuf, Hernandez, Dena, Bandres-Ciga, Sara, Blauwendraat, Cornelis, Singleton, Andrew, Houlden, Henry, Hardy, John, and Rizig, Mie

Published
2022
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15. A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study

Author

Akpa, Onoja, Sarfo, Fred S., Owolabi, Mayowa, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Ogbole, Godwin, Tiwari, Hemant K., Jenkins, Carolyn, Fakunle, Adekunle G., Olowookere, Samuel, Uvere, Ezinne O., Akinyemi, Joshua, Arulogun, Oyedunni, Akpalu, Josephine, Tito-Ilori, Moyinoluwalogo M., Asowata, Osahon J., Ibinaiye, Philip, Akisanya, Cynthia, Oyinloye, Olalekan I., Appiah, Lambert, Sunmonu, Taofik, Olowoyo, Paul, Agunloye, Atinuke M., Adeoye, Abiodun M., Yaria, Joseph, Lackland, Daniel T., Arnett, Donna, Laryea, Ruth Y., Adigun, Taiwo O., Okekunle, Akinkunmi P., Calys-Tagoe, Benedict, Ogah, Okechukwu S., Ogunronbi, Mayowa, Obiabo, Olugbo Y., Isah, Suleiman Y., Dambatta, Hamisu A., Tagge, Raelle, Ogenyi, Obande, Fawale, Bimbo, Melikam, Chimdinma L., Onasanya, Akinola, Adeniyi, Sunday, Akinyemi, Rufus, and Ovbiagele, Bruce

Published
2021
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16. Influence of age on links between major modifiable risk factors and stroke occurrence in West Africa

Author

Sarfo, Fred S., Akpa, Onoja, Ovbiagele, Bruce, Akpalu, Albert, Wahab, Kolawole, Komolafe, Morenikeji, Obiako, Reginald, Owolabi, Lukman, Osaigbovo, Godwin O., Jenkins, Carolyn, Ogbole, Godwin, Fakunle, Adekunle, Tiwari, Hemant K., Arulogun, Oyedunni, Arnett, Donna K., Asowata, Osahon, Ogah, Okechukwu, Akinyemi, Rufus O., and Owolabi, Mayowa O.

Published
2021
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19. Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study.

Author

Fakunle, Adekunle Gregory, Okekunle, Akinkunmi Paul, Asowata, Osahon Jeffery, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O, Adeoye, Abiodun M, Tiwari, Hemant K, Uvere, Ezinne O, Akinyemi, Joshua, Jenkins, Carolyn, Arulogun, Oyedunni, Ibinaiye, Philip, Appiah, Lambert T, and Bello, Temilade

Subjects
TOBACCO use, MAGNETIC resonance imaging, COMPUTED tomography, SYMPTOMS, STROKE
Abstract

Introduction Non-cigarette tobacco (NCT) represents a form of tobacco use with a misperceived significance in chronic disease events. Whether NCT use is sufficient to promote stroke events, especially among Africans, is yet to be understood. This study assessed the relationship between NCT use and stroke among indigenous Africans. Methods A total of 7617 respondents (NCT users: 41 vs. non-NCT: 7576) from the Stroke Investigative Research and Educational Network (SIREN) study were included in the current analysis. NCT use was defined as self-reported use of smoked (cigars or piper) or smokeless (snuff or chewed) tobacco in the past year preceding stroke events. Stroke was defined based on clinical presentation and confirmed with a cranial computed tomography/magnetic resonance imaging. Multivariable-adjusted logistic regression was applied to estimate the odds ratio (OR) and 95% confidence interval (CI) for the relationship of NCT with stroke at a two-sided p <.05. Results Out of the 41 (0.54%) who reported NCT use, 27 (65.9%) reported using smokeless NCT. NCT users were older than non-NCT users (62.8 ± 15.7 vs. 57.7 ± 14.8 years). Overall, NCT use was associated with first-ever stroke (OR: 2.08; 95% CI: 1.02, 4.23) in the entire sample. Notably, smokeless NCT use was independently associated with higher odds of stroke (OR: 2.74; 95% CI: 1.15, 6.54), but smoked NCT use (OR: 0.16; 95% CI: 0.02, 1.63) presented a statistically insignificant association after adjusting for hypertension and other covariates. Conclusions NCT use was associated with higher odds of stroke, and public health interventions targeting NCT use might be promising in reducing the burden of stroke among indigenous Africans. Implications A detailed understanding of the relationship between NCT use and stroke will likely inform well-articulated policy guidance and evidence-based recommendations for public health prevention and management of stroke on the African continent. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Dietary patterns associated with hypertension among stroke-free indigenous Africans: insights from the Stroke Investigative Research and Educational Network study.

Author

Okekunle, Akinkunmi Paul, Asowata, Osahon Jeffery, Akpa, Onoja Matthew, Fakunle, Adekunle Gregory, Bodunde, Ifeoluwa, Komolafe, Morenikeji, Arulogun, Oyedunni, Sarfo, Fred Stephen, Obiako, Reginald, Osaigbovo, Godwin, Ogbole, Godwin, Bello, Abiodun, Adeniyi, Sunday, Calys-Tagoe, Benedict, Appiah, Lambert, Jenkins, Carolyn, Oyinloye, Olalekan, Dambatta, Hamisu, Balogun, Olayemi, and Singh, Arti

Published
2024
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22. Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study

Author

Rizig, Mie, primary, Bandres-Ciga, Sara, additional, Makarious, Mary B, additional, Ojo, Oluwadamilola Omolara, additional, Crea, Peter Wild, additional, Abiodun, Oladunni Victoria, additional, Levine, Kristin S, additional, Abubakar, Sani Atta, additional, Achoru, Charles Obiora, additional, Vitale, Dan, additional, Adeniji, Olaleye Akinmola, additional, Agabi, Osigwe Paul, additional, Koretsky, Mathew J, additional, Agulanna, Uchechi, additional, Hall, Deborah A, additional, Akinyemi, Rufus Olusola, additional, Xie, Tao, additional, Ali, Mohammed Wulgo, additional, Shamim, Ejaz A, additional, Ani-Osheku, Ifeyinwa, additional, Padmanaban, Mahesh, additional, Arigbodi, Ohwotemu Michael, additional, Standaert, David G, additional, Bello, Abiodun Hamzat, additional, Dean, Marissa N, additional, Erameh, Cyril Oshomah, additional, Elsayed, Inas, additional, Farombi, Temitope Hannah, additional, Okunoye, Olaitan, additional, Fawale, Michael Bimbola, additional, Billingsley, Kimberley J, additional, Imarhiagbe, Frank Aiwansoba, additional, Jerez, Pilar Alvarez, additional, Iwuozo, Emmanuel Uzodinma, additional, Baker, Breeana, additional, Komolafe, Morenikeji Adeyoyin, additional, Malik, Laksh, additional, Nwani, Paul Osemeke, additional, Daida, Kensuke, additional, Nwazor, Ernest Okwundu, additional, Miano-Burkhardt, Abigail, additional, Nyandaiti, Yakub Wilberforce, additional, Fang, Zih-Hua, additional, Obiabo, Yahaya Olugbo, additional, Kluss, Jillian H, additional, Odeniyi, Olanike Adedoyin, additional, Hernandez, Dena G, additional, Odiase, Francis Ehidiamen, additional, Tayebi, Nahid, additional, Ojini, Francis Ibe, additional, Sidranksy, Ellen, additional, Onwuegbuzie, Gerald Awele, additional, D'Souza, Andrea M, additional, Osaigbovo, Godwin Osawaru, additional, Berhe, Bahafta, additional, Osemwegie, Nosakhare, additional, Reed, Xylena, additional, Oshinaike, Olajumoke Olufemi, additional, Leonard, Hampton L, additional, Otubogun, Folajimi Morenikeji, additional, Alvarado, Chelsea X, additional, Oyakhire, Shyngle Imiewan, additional, Ozomma, Simon Izuchukwu, additional, Samuel, Sarah Chabiri, additional, Taiwo, Funmilola Tolulope, additional, Wahab, Kolawole Wasiu, additional, Zubair, Yusuf Agboola, additional, Iwaki, Hirotaka, additional, Kim, Jonggeol Jeffrey, additional, Morris, Huw R, additional, Hardy, John, additional, Nalls, Mike A, additional, Heilbron, Karl, additional, Norcliffe-Kaufmann, Lucy, additional, Blauwendraat, Cornelis, additional, Houlden, Henry, additional, Singleton, Andrew, additional, Okubadejo, Njideka Ulunma, additional, Okubadejo, Njideka, additional, Ojo, Oluwadamilola, additional, Abiodun, Oladunni, additional, Achoru, Charles, additional, Agabi, Osigwe, additional, Akinyemi, Rufus, additional, Ali, Mohammed, additional, Arigbodi, Ohwotemu, additional, Bello, Abiodun, additional, Erameh, Cyril, additional, Farombi, Temitope, additional, Fawale, Michael, additional, Imarhiagbe, Frank, additional, Iwuozo, Emmanuel, additional, Komolafe, Morenikeji, additional, Nwani, Paul, additional, Nwazor, Ernest, additional, Nyandaiti, Yakub, additional, Obiabo, Yahaya, additional, Odeniyi, Olanike, additional, Odiase, Francis, additional, Ojini, Francis, additional, Onwuegbuzie, Gerald, additional, Osaigbovo, Godwin, additional, Oshinaike, Olajumoke, additional, Otubogun, Folajimi, additional, Oyakhire, Shyngle, additional, Ozomma, Simon, additional, Samuel, Sarah, additional, Taiwo, Funmilola, additional, Wahab, Kolawole, additional, Zubair, Yusuf, additional, Gams Massi, Daniel, additional, Gueumekane Bila lamou, Eric, additional, Njamnshi Nfor, Leonard, additional, Magnerou, Mélanie Annick, additional, Fogang Fogoum, Yannick, additional, Shalash, Ali, additional, El-FawaI, Hassan, additional, Khedr, Eman, additional, Fawi, Gharib, additional, A. Eltantawi, Mohamed, additional, Salama, Mohamed, additional, El-Jaafary, Shaimaa, additional, Hamed, Sharifa, additional, Tafesse Mengesha, Abenet, additional, Alemayehu Ayele, Biniyam, additional, Melka Oda, Dereje, additional, Zenebe Zewde, Yared, additional, Debebe Gelan, Yohanesse, additional, AkpaIu, Albert, additional, Charway-Felli, Augustina, additional, Stephen Sarfo, Fred, additional, Adjei, Patrick, additional, Obese, Vida, additional, Bocoum, Abdoulaye, additional, Koita, Abdou, additional, Oumar Guinto, Cheick, additional, Coulibaly, Toumany, additional, Maiga, Youssoufa, additional, Kone, Zaynab, additional, Bell, Abiodun, additional, Adebowale, Akintunde A., additional, Akpekpe, John, additional, lyagba, Alagoma, additional, Wulgo, Ali Mohammed, additional, Arabambi, Babawale, additional, Agu, Christian, additional, Dike, Franklin, additional, Ishola, Ismail, additional, Abiodun, Kehinde, additional, Ekenze, Oluchi, additional, Agabi Osigwe, Paul, additional, Balarabe, Salisu, additional, Abubakar, Sani, additional, Williams, Uduak, additional, Fall, Maouly, additional, Mamadou Diop, Alassane, additional, Hilaire Dominique, Ewodo Touna, additional, Mochan, Andre, additional, Modi, Girish, additional, Dindayal, Saiesha, additional, Ali Awadelkareem, Eman, additional, Dahawi, Maha, additional, Awadelkareem, Mosab Ali, additional, Misbah, Sarah, additional, Mushengez, Brighton, additional, Kimambo, Henrika, additional, Msango, Leonard, additional, Adebayo, Philip, additional, OKeng, Kigocha, additional, Diekker, Marieke, additional, URassa, Sarah, additional, Gouider, Riadh, additional, Ben Djebara, Mouna, additional, Gargouri, Amina, additional, Kacem, Imen, additional, Nasri, Amina, additional, Mrabet, Saloua, additional, Sghaier, Ikram, additional, Mkada, Imen, additional, Atadzhanov, Masharip, additional, Chishimba, Lorraine, additional, Rizig, Mie, additional, Jama, Fatumah, additional, Nalls, Mike, additional, Shamim, Ejaz, additional, Jonas, Cabell, additional, Williamson, Jared, additional, Hall, Deborah A., additional, Rosenbaum, Marc, additional, Davis, Staci, additional, Dean, Marissa, additional, Cromer, Candace, additional, Smith, Jenna, additional, Ruffrage, Lauren, additional, Richardson, Joseph, additional, Sipma, Rebeka, additional, Padmanaban, Manesh, additional, Warren, Natalie, additional, Mercado, Tomas, additional, Disbrow, Elizabeth, additional, Chauppeta, Brian, additional, Thomas-Dean, Fermine, additional, Toms, Jamie, additional, Lofton, Katelyn, additional, Rawls, Ashley, additional, Rizer, Kyle, additional, Black, Nieci, additional, Solle, Justin, additional, O'Grady, Alyssa, additional, Sherer, Todd, additional, Fiske, Brian, additional, Başak, A. Nazlı, additional, Tan, Ai Huey, additional, Noyce, Alastair, additional, Akpalu, Albert, additional, Espay, Alberto, additional, Martínez-Carrasco, Alejandro, additional, Medina, Alex, additional, Zimprich, Alexander, additional, Brice, Alexis, additional, Karimova, Altynay, additional, Hernandez, Alvaro, additional, Illarionova, Anastasia, additional, Quattrone, Andrea, additional, Singleton, Andrew B, additional, Sobering, Andrew K., additional, Vinuela, Angel, additional, Sanyaolu, Arinola, additional, Schumacher-Schuh, Artur F., additional, Kishore, Asha, additional, Ahmad-Annuar, Azlina, additional, Al Mubarak, Bashayer, additional, Tang, Beisha, additional, Pizarro Galleguillos, Benjamin, additional, Jeon, Beomseok, additional, Siddiqi, Bernadette, additional, Casey, Bradford, additional, Mollenhauer, Brit, additional, Carroll, Camille, additional, Rieder, Carlos, additional, Pantazis, Caroline B., additional, Comart, Charisse, additional, Lin, Chin-Hsien, additional, Klein, Christine, additional, Bale, Claire, additional, Shepherd, Claire E, additional, Wegel, Claire, additional, Martinez-Ramirez, Daniel, additional, Hall, Deborah, additional, Hernandez, Dena, additional, KP, Divya, additional, Nguyen, Duan, additional, Fon, Edward A., additional, Dadiotis, Efthymios, additional, Riley, Ekemini, additional, Iakovenko, Elena, additional, Stafford, Ellie, additional, Gatto, Emilia M, additional, Valente, Enza Maria, additional, Vollstedt, Eva-Juliane, additional, Faghri, Faraz, additional, Genc, Gencer, additional, Xiromerisiou, Georgia, additional, Hadjigorgiou, Georgios, additional, Hiu-Fai Chan, Germaine, additional, Arboleda, Gonzalo, additional, Kaishibayeva, Gulnaz, additional, Höglinger, Günter, additional, Leonard, Hampton, additional, Madoev, Harutyun, additional, Chen, Honglei, additional, Wu, Hsiu-Chuan, additional, Shang, Huifang, additional, F. Mata, Ignacio, additional, Keller Sarmiento, Ignacio Juan, additional, Dagklis, Ioannis, additional, Tarnanas, Ioannis, additional, Aasly, Jan O., additional, Hoenicka, Janet, additional, Corvol, Jean-Christophe, additional, Foo, Jia Nee, additional, Guo, Jifeng, additional, Junker, Johanna, additional, Carr, Jonathan, additional, Kim, Jonggeol Jeff, additional, Orozco, Jorge, additional, Jankovic, Joseph, additional, Shulman, Joshua, additional, Hunter, Julie, additional, Solle, Justin C., additional, Murphy, Kaileigh, additional, Nuytemans, Karen, additional, Kieburtz, Karl, additional, Lohmann, Katja, additional, Marek, Kenneth, additional, Mok, Kin Ying, additional, Kumar, Kishore, additional, Levine, Kristin, additional, Chahine, Lana M., additional, Lange, Lara M., additional, Pihlstrøm, Lasse, additional, Screven, Laurel, additional, Stefanis, Leonidas, additional, Shulman, Lisa, additional, Marsili, Luca, additional, Parnetti, Lucilla, additional, Kuhl, Maggie, additional, Funayama, Manabu, additional, Sharma, Manu, additional, Tan, Manuela, additional, Kauffman, Marcelo, additional, Miranda, Marcelo, additional, Bustamante, Maria Leonor, additional, Stamelou, Maria, additional, Periñan Tocino, Maria Teresa, additional, Cornejo-Olivas, Mario, additional, Jimenez del Rio, Marlene, additional, Koretsky, Mathew, additional, Rodriguez-Violante, Mayela, additional, Ellis, Melina, additional, Avenali, Micol, additional, Rentería, Miguel E., additional, Inca-Martines, Miguel z, additional, Nalls, Mike A., additional, Ibrahim Norlinah, Mohamed, additional, Umair, Muhammad, additional, Ip, Nancy, additional, Louie, Naomi, additional, Cheung, Nelson Yuk-Fai, additional, Mencacci, Niccolò Emanuele, additional, Wood, Nicholas, additional, Williams, Nigel, additional, Hattori, Nobutaka, additional, Abdul Murad, Nor Azian, additional, Ibrahim, Norlinah Mohamed, additional, Monchi, Oury, additional, Öztop Çakmak, Özgür, additional, Öztop Çakmak, Patricio Öztop Çakmak, additional, Lewis, Patrick Alfryn, additional, Pastor, Pau, additional, Reyes-Pérez, Paula, additional, Saffie Awad, Paula, additional, Chana, Pedro, additional, Chan, Phillip, additional, Kung, Pin-Jui, additional, Chan, Piu, additional, Pal, Pramod, additional, Lingappa Kukkle, Prashanth, additional, Ojha, Rajeev, additional, Kaiyrzhanov, Rauan, additional, Krüger, Rejko, additional, Amouri, Rim, additional, Weil, Rimona, additional, Rajan, Roopa, additional, Alcalay, Roy, additional, Wu, Ruey-Meei, additional, Borgohain, Rupam, additional, Sassi, Samia Ben, additional, Khachatryan, Samson, additional, El-Sadig, Sarah, additional, Wu, Serena, additional, Groppa, Sergio, additional, Azmin, Shahrul, additional, Lim, Shen-Yang, additional, Ur-Rehman, Shoaib, additional, Ertan, Sibel, additional, Stott, Simon, additional, Jasaitye, Simona, additional, Chowdhury, Sohini, additional, Dumanis, Sonya, additional, Bardien, Soraya, additional, Lubbe, Steven, additional, Koks, Sulev, additional, Dey, Sumit, additional, Foroud, Tatiana, additional, Fon, Ted, additional, Beach, Thomas, additional, Gasser, Thomas, additional, Anderson, Tim, additional, Nguyen, Toan, additional, Schirinzi, Tommaso, additional, Shiraishi, Tomotaka, additional, Pitcher, Toni, additional, Tumas, Vitor, additional, Mohamed, Wael, additional, Kamel, Walaa A., additional, Luo, Wei, additional, Zhou, Xiaopu, additional, Zewde, Yared Z., additional, Song, Yeajin, additional, Wen, Yi, additional, Wu, Yihru, additional, Joong Kim, Yun, additional, and Tavadyan, Zaruhi, additional

Published
2023
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23. Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage

Author

Komolafe, Morenikeji A., primary, Sunmonu, Taofiki, additional, Akinyemi, Joshua, additional, Sarfo, Fred S., additional, Akpalu, Albert, additional, Wahab, Kolawole, additional, Obiako, Reginald, additional, Owolabi, Lukman, additional, Osaigbovo, Godwin O., additional, Ogbole, Godwin, additional, Tiwari, Hemant K., additional, Jenkins, Carolyn, additional, Lackland, Daniel T., additional, Fakunle, Adekunle G., additional, Uvere, Ezinne, additional, Akpa, Onoja, additional, Dambatta, Hamisu A., additional, Akpalu, Josephine, additional, Onasanya, Akinola, additional, Olaleye, Adeniji, additional, Ogah, Okechukwu S., additional, Isah, Sulaiman Y., additional, Fawale, Micheal B., additional, Adebowale, Akintunde, additional, Okekunle, Akinkunmi P., additional, Arnett, Donna, additional, Adeoye, Abiodun M., additional, Agunloye, Atinuke M., additional, Bello, Abiodun H., additional, Aderibigbe, Adeniyi S., additional, Idowu, Ahmed O., additional, Sanusi, Ahmad A., additional, Ogunmodede, Adebimpe, additional, Balogun, Simon A., additional, Egberongbe, Adedeji A., additional, Rotimi, Folorunso T., additional, Fredrick, Adeyemi, additional, Akinnuoye, Andrew O., additional, Adeniyi, Folu A., additional, Calys-Tagoe, Benedict, additional, Adebayo, Philip, additional, Arulogun, Oyedunni, additional, Agbogu-Ike, Obiageli U., additional, Yaria, Joseph, additional, Appiah, Lambert, additional, Ibinaiye, Philip, additional, Singh, Arti, additional, Adeniyi, Sunday, additional, Olalusi, Oladotun, additional, Mande, Aliyu, additional, Balogun, Olayemi, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional

Published
2023
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25. Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study

Author

Fakunle, Adekunle Gregory, primary, Okekunle, Akinkunmi Paul, additional, Asowata, Osahon Jeffery, additional, Akpa, Onoja, additional, Sarfo, Fred S, additional, Akpalu, Albert, additional, Wahab, Kolawole, additional, Obiako, Reginald, additional, Komolafe, Morenikeji, additional, Owolabi, Lukman, additional, Osaigbovo, Godwin O, additional, Adeoye, Abiodun M, additional, Tiwari, Hemant K, additional, Uvere, Ezinne O, additional, Akinyemi, Joshua, additional, Jenkins, Carolyn, additional, Arulogun, Oyedunni, additional, Ibinaiye, Philip, additional, Appiah, Lambert T, additional, Bello, Temilade, additional, Singh, Arti, additional, Yaria, Joseph, additional, Calys-Tagoe, Benedict, additional, Ogbole, Godwin, additional, Chukwuonye, Ijezie, additional, Melikam, Chidinma, additional, Adebayo, Philip, additional, Mensah, Yaw, additional, Adebayo, Oladimeji, additional, Adeniyi, Sunday, additional, Oguike, Wisdom, additional, Donna, Arnett, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional

Published
2023
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27. Risk Assessment Score and χ 2 Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study

Author

Asowata, Osahon, primary, Okekunle, Akinkunmi, additional, Akpa, Onoja, additional, Fakunle, Adekunle, additional, Akinyemi, Joshua, additional, Komolafe, Morenikeji, additional, Sarfo, Fred, additional, Akpalu, Albert, additional, Obiako, Reginald, additional, Wahab, Kolawole, additional, Osaigbovo, Godwin, additional, Owolabi, Lukman, additional, Jenkins, Carolyn, additional, Calys-Tagoe, Benedict, additional, Arulogun, Oyedunni, additional, Ogbole, Godwin, additional, Ogah, Okechukwu S., additional, Appiah, Lambert, additional, Ibinaiye, Philip, additional, Adebayo, Philip, additional, Singh, Arti, additional, Adeniyi, Sunday, additional, Mensah, Yaw, additional, Laryea, Ruth, additional, Balogun, Olayemi, additional, Chukwuonye, Ijezie, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional

Published
2023
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28. Risk Factor Characterization of Ischemic Stroke Subtypes Among West Africans

Author

Sarfo, Fred S., Ovbiagele, Bruce, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Ogbole, Godwin, Calys-Tagoe, Benedict, Fakunle, Adekunle, Sanni, Taofeek, Mulugeta, Gebregziabher, Abdul, Salaam, Akintunde, Adeseye A., Olowookere, Samuel, Uvere, Ezinne O., Ibinaiye, Philip, Akinyemi, Joshua, Uwanuruochi, Kelechukwu, Olayemi, Balogun, Odunlami, Olufemi A., Abunimye, Esther, Arulogun, Oyedunni, Isah, Suleiman Y., Abubakar, Sani A., Oladimeji, Adebayo, Adebayo, Philip, Shidali, Vincent, Chukwuonye, Innocent I., Akpalu, Josephine, Tito-Ilori, Moyinoluwalogo M., Asowata, Osahon J., Sanya, Emmanuel O., Amusa, Ganiyu, Onyeonoro, Ugochukwu, Ogunmodede, James A., Sule, Abdullateef G., Akisanya, Cynthia, Mensah, Yaw, Oyinloye, Olalekan I., Appiah, Lambert, Agunloye, Atinuke M., Osaigbovo, Godwin O., Olabinri, Eunice, Kolo, Philip M., Okeke, Obiora, Adeoye, Abiodun M., Ajose, Olabamiji, Jenkins, Carolyn, Lackland, Daniel T., Egberongbe, Adedeji A., Adeniji, Olaleye, Ohifemen Adeleye, Osimhiarherhuo, Tiwari, Hemant K., Arnett, Donna, Laryea, Ruth Y., Olunuga, Taiwo, Akinwande, Kazeem S., Imoh, Lucius, Ogah, Okechukwu S., Melikam, Ezinne S., Adebolaji, Adeyemo, Oguike, Wisdom, Ogunronbi, Olumayowa, Adeniyi, Wasiu, Olugbo, Obiabo Y., Bello, Abiodun H., Ohagwu, Kenneth A., Ogunjimi, Luqman, Agyekum, Francis, Iheonye, Henry, Adesina, Julius, Diala, Samuel, Dambatta, Hamisu A., Ikubor, Joyce, Singh, Arti, Adamu, Sheila, Obese, Vida, Adusei, Nathaniel, Owusu, Dorcas, Ampofo, Michael, Tagge, Raelle, Efidi, Richard, Fawale, Bimbo, Yaria, Joseph, Akinyemi, Rufus, and Owolabi, Mayowa

Published
2021
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31. Factors associated with frequency of fruit and vegetable consumption among selected sub-Saharan African populations: evidence from the Cardiovascular H3Africa Innovation Resource Project.

Author

Okekunle, Akinkunmi Paul, Asowata, Osahon Jeffery, Akpa, Onoja Matthew, Fakunle, Adekunle Gregory, Chikowore, Tinashe, Mohamed, Shukri F, Obiako, Reginald, Komolafe, Morenikeji, Osaigbovo, Godwin O, Ogbole, Godwin, Arulogun, Oyedunni, Sarfo, Fred Stephen, Wahab, Kolawole, Owolabi, Lukman, Akinyemi, Joshua, Akpalu, Albert, Uvere, Ezinne, Akinyemi, Rufus, Jenkins, Carolyn, and Arnett, Donna K

Subjects
SUB-Saharan Africans, VEGETABLES, FRUIT, DISEASE risk factors, FAMILY history (Medicine)
Abstract

Background Frequent fruit and vegetable consumption is considered a promising dietary behaviour that protects health. However, most existing studies about the factors associated with this phenomenon among Africans are based on single-country reports, apart from one meta-regression combining smaller studies. This study harmonized large datasets and assessed factors associated with the frequency of fruit and vegetable consumption in this population. Methods Individual-level data on sociodemographics, lifestyle and diet from 20 443 participants across five African countries (Burkina Faso, Ghana, Kenya, South Africa and Nigeria), from the Stroke Investigative Research and Educational Network (SIREN) and Africa Wits-INDEPTH partnership for Genomic Research (AWI-Gen) studies, were harmonized. Total frequency of fruit and vegetable consumption (in portions/week) was classified as 'low' (≤6), 'moderate' (7–14) and 'high' (≥15). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of factors associated with the total frequency of fruit and vegetable consumption (using 'low' consumption as the reference) were estimated using multinomial regression models. Results Mean age of participants was 54.3 ± 11.8 years, 10 641 (52.1%) were female, and the median (interquartile range) frequency of total fruit and vegetable consumption was 10.0 (4.0, 21.0) portions/week. Participants with a family history of cardiovascular disease [moderate (aOR, 0.92; 95% CI, 0.85, 1.00) and high (aOR, 0.85; 95% CI, 0.78, 0.92)], current smokers [moderate (aOR, 0.83; 95% CI, 0.74, 0.94) and high (aOR, 0.78; 95% CI, 0.69, 0.88)], current alcohol users [moderate (aOR, 0.92; 95% CI, 0.85, 1.00) and high (aOR, 0.82; 95% CI, 0.76, 0.89)] and physically inactive participants [moderate (aOR, 0.85; 95% CI, 0.75, 0.96) and high (aOR, 0.80; 95% CI, 0.70, 0.90)] were less likely to consume fruits and vegetables frequently. Conclusion Africans with lifestyle risk factors for cardiovascular disease were less likely to consume fruit and vegetables frequently. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Abstract P155: Low Vegetable Consumption Doubles The Risk Of Stroke Among Hypertensives In West Africa

Author

Asowata, Osahon J, primary, Bodunde, Ifeoluwa, additional, Danladi, David K, additional, Akpa, Onoja M, additional, Fakunle, Adekunle, additional, SARFO, FRED S, additional, Akpalu, Albert, additional, Obiako, Reginald, additional, Wahab, Kolawole W, additional, Osaigbovo, Godwin, additional, Ogbole, Godwin, additional, Akinyemi, Joshua, additional, Owolabi, Lukman, additional, Komolafe, Morenikeji, additional, Akinyemi, Rufus O, additional, Ovbiagele, Bruce, additional, Okekunle, Akinkunmi P, additional, and Owolabi, Mayowa, additional

Published
2023
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33. MAPT allele and haplotype frequencies in Nigerian Africans: Population distribution and association with Parkinson's disease risk and age at onset

Author

Okunoye, Olaitan, primary, Ojo, Oluwadamilola O., additional, Abiodun, Oladunni, additional, Abubakar, Sani, additional, Achoru, Charles, additional, Adeniji, Olaleye, additional, Agabi, Osigwe, additional, Agulanna, Uchechi, additional, Akinyemi, Rufus, additional, Ali, Mohammed, additional, Ani-Osheku, Ifeyinwa, additional, Arigbodi, Ohwotemu, additional, Bello, Abiodun, additional, Erameh, Cyril, additional, Farombi, Temitope, additional, Fawale, Michael, additional, Imarhiagbe, Frank, additional, Iwuozo, Emmanuel, additional, Komolafe, Morenikeji, additional, Nwani, Paul, additional, Nwazor, Ernest, additional, Nyandaiti, Yakub, additional, Obiabo, Yahaya, additional, Odeniyi, Olanike, additional, Odiase, Francis, additional, Ojini, Francis, additional, Onwuegbuzie, Gerald, additional, Osaigbovo, Godwin, additional, Osemwegie, Nosakhare, additional, Oshinaike, Olajumoke, additional, Otubogun, Folajimi, additional, Oyakhire, Shyngle, additional, Ozomma, Simon, additional, Samuel, Sarah, additional, Taiwo, Funmilola, additional, Wahab, Kolawole, additional, Zubair, Yusuf, additional, Hernandez, Dena, additional, Bandres-Ciga, Sara, additional, Blauwendraat, Cornelis, additional, Singleton, Andrew, additional, Houlden, Henry, additional, Hardy, John, additional, Rizig, Mie, additional, and Okubadejo, Njideka, additional

Published
2023
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34. Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study

Author

Owolabi, Mayowa Ojo, Sarfo, Fred Stephen, Akinyemi, Rufus, Gebregziabher, Mulugeta, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Owolabi, Lukman, Ovbiagele, Bruce, Tiwari, Hemant K, Arnett, Donna, Lackland, Daniel, Adeoye, Abiodun Moshood, Akin, Ojagbemi, Ogbole, Godwin, Jenkins, Carolyn, Arulogun, Oyedunni, Ryan, Irvin Marguerite, Armstrong, Kevin, Olowoyo, Paul, Komolafe, Morenikeji, Osaigbovo, Godwin, Obiabo, Olugbo, Chukwuonye, Innocent, Adebayo, Philip, Adebayo, Oladimeji, Omololu, Ayanfe, Otubogun, Folajimi, Olaleye, Adeniji, Durodola, Amina, Olunuga, Taiwo, Akinwande, Kazeem, Aridegbe, Mayowa, Fawale, Bimbo, Adeleye, Omisore, Kolo, Philip, Appiah, Lambert, Singh, Arti, Adamu, Sheila, Awuah, Dominic, Saulson, Raelle, Agyekum, Francis, Shidali, Vincent, Ogah, Okechukwu, Oguntade, Ayodipopo, Umanruochi, Kelechi, Iheonye, Henry, Imoh, Lucius, Afolaranmi, Tolulope, Calys-Tagoe, Benedict, Okeke, Obiora, Fakunle, Adekunle, Akinyemi, Joshua, Akpalu, Josephine, Ibinaiye, Philip, Agunloye, Atinuke, Sanni, Taofeeq, Bisi, Ayotunde, Efidi, Chika, Bock-Oruma, Andrew, Melikam, Sylvia, Olaniyan, Lanre, Yaria, Joseph, Odo, Chidi Joseph, Lakoh, Sulaiman, Ogunjimi, Luqman, Salaam, Abdul, Oyinloye, Lekan, Asaleye, Caroline, Sanya, Emmanuel, Olowookere, Samuel, Makanjuola, Akintomiwa, Oguntoye, Ayobami, Uvere, Ezinne, Faniyan, Moyinoluwalogo, Akintunde, Adeseye, Kehinde, Issa, Diala, Samuel, Adeleye, Osimhiarherhuo, Ajose, Olabanji A., Onyeonoro, Ugochukwu, Amusa, Adeniyi G., Owusu, Dorcas, Mensah, Yaw, Owolabi, Mayowa O, and Sarfo, Fred

Published
2018
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35. Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke

Author

Owolabi, Mayowa, Ogbole, Godwin, Akinyemi, Rufus, Salaam, Kehinde, Akpa, Onoja, Mongkolwat, Pattanasak, Omisore, Adeleye, Agunloye, Atinuke, Efidi, Richard, Odo, Joseph, Makanjuola, Akintomiwa, Akpalu, Albert, Sarfo, Fred, Owolabi, Lukman, Obiako, Reginald, Wahab, Kolawole, Sanya, Emmanuel, Adebayo, Philip, Komolafe, Morenikeji, Adeoye, Abiodun Moshood, Fawale, Michael B, Akinyemi, Joshua, Osaigbovo, Godwin, Sunmonu, Taofiki, Olowoyo, Paul, Chukwuonye, Innocent, Obiabo, Yahaya, Ibinaiye, Philip, Dambatta, Abdul, Mensah, Yaw, Abdul, Salaam, Olabinri, Eunice, Ikubor, Joyce, Oyinloye, Olalekan, Odunlami, Femi, Melikam, Ezinne, Saulson, Raelle, Kolo, Philip, Ogunniyi, Adesola, and Ovbiagele, Bruce

Published
2017
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36. Chapter 24 - Africa region: Nigeria

Author

Komolafe, Morenikeji A., Ayodele, Kayode P., Olaogun, Matthew O.B., Ogunbona, Philip O., Fawale, Michael B., Ogundele, Abiola O., Adebowale, Akintunde, Akinniyi, Oluwasegun T., Ayenowowan, Sunday O., Jubril, Abimbola M., Idowu, Ahmed O., Sanusi, Ahmad A., Bello, Abiodun H., and Ogunba, Kolawole S.

Published
2024
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38. Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson’s disease in Black South African and Nigerian patients

Author

Oluwole, Oluwafemi G., Kuivaniemi, Helena, Abrahams, Shameemah, Haylett, William L., Vorster, Alvera A., van Heerden, Carel J., Kenyon, Colin P., Tabb, David L., Fawale, Michael B., Sunmonu, Taofiki A., Ajose, Abiodun, Olaogun, Matthew O., Rossouw, Anastasia C., van Hillegondsberg, Ludo S., Carr, Jonathan, Ross, Owen A., Komolafe, Morenikeji A., Tromp, Gerard, and Bardien, Soraya

Published
2020
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39. Risk Assessment Score and Chi-Square Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study.

Author

Asowata, Osahon J., Okekunle, Akinkunmi Paul, Akpa, Onoja M., Fakunle, Adekunle Gregory, Akinyemi, Joshua O., Komolafe, Morenikeji Adeyoyin, Sarfo, Fred Stephen, Akpalu, Albert K., Obiako, Reginald, Wahab, Kolawole W., Osaigbovo(Osawaru), Godwin O., Owolabi, Lukman F., Jenkins, Carolyn M., Calys-Tagoe, Benedict Nii Laryea, Arulogun, Oyedunni Sola, Ogbole, Godwin I., Ogah, Okechukwu Samuel, Lambert, Appiah T., Ibinaiye, Philip Oluleke, and Adebayo, Philip B.

Abstract

BACKGROUND: This study aimed to develop a risk-scoring model for hypertension among Africans. METHODS: In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were applied to 13 risk factors. We randomly split the dataset into training and testing data at a ratio of 80:20. Constant and standardized weights were assigned to factors significantly associated with hypertension in the regression model to develop a probability risk score on a scale of 0 to 1 using a logistic regression model. The model accuracy was assessed to estimate the cutoff score for discriminating hypertensives. RESULTS: Mean age was 59.9±13.3 years, 56.0% were hypertensives, and 8 factors, including diabetes, age =65 years, higher waist circumference, (BMI) =30 kg/m², lack of formal education, living in urban residence, family history of cardiovascular diseases, and dyslipidemia use were associated with hypertension. Cohen κ was maximal at =0.28, and a total probability risk score of =0.60 was adopted for both statistical weighting for risk quantification of hypertension in both datasets. The probability risk score presented a good performance--receiver operating characteristic: 64% (95% CI, 61.0-68.0), a sensitivity of 55.1%, specificity of 71.5%, positive predicted value of 70.9%, and negative predicted value of 55.8%, in the test dataset. Similarly, decision tree had a predictive accuracy of 67.7% (95% CI, 66.1-69.3) for the training set and 64.6% (95% CI, 61.0-68.0) for the testing dataset. CONCLUSIONS: The novel risk-scoring model discriminated hypertensives with good accuracy and will be helpful in the early identification of community-based Africans vulnerable to hypertension for its primary prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans

Author

Sarfo, Fred S., Ovbiagele, Bruce, Gebregziabher, Mulugeta, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Ogbole, Godwin, Akinyemi, Rufus, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Lackland, Daniel, Arnett, Donna, Tiwari, Hemant, Markus, Hugh S., Akinyemi, Joshua, Oguntade, Ayodipupo, Fawale, Bimbo, Adeoye, Abiodun, Olugbo, Obiabo, Ogunjimi, Luqman, Osaigbovo, Godwin, Jenkins, Carolyn, Chukwuonye, Ijezie, Ajose, Olabamiji, Oyinloye, Lekan, Mutiso, Fedelis, Laryea, Ruth, Calys-Tagoe, Benedict, Salaam, Abdul, Amusa, Ganiyu, Olowookere, Samuel, Imoh, Chidiebere, Mande, Aliyu, Arulogun, Oyedunni, Adekunle, Fakunle, Appiah, Lambert, Balogun, Olayemi, Singh, Arti, Adeleye, Osi, Ogah, Okechukwu, Makanjuola, Akintomiwa, Owusu, Dorcas, Kolo, Philip, Adebayo, Oladimeji, Agunloye, Atinuke, Shidali, Vincent, Faniyan, Moyinoluwalogo, Lakoh, Sulaiman, Diala, Samuel, Iheonye, Henry, Efidi, Chika, Sanya, Emmanuel, Sunmonu, Taofiki, Akintunde, Adeseye, and Owolabi, Mayowa

Published
2020
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41. Genome-wide Association Identifies Novel Etiological Insights Associated with Parkinson’s Disease in African and African Admixed Populations

Author

Rizig, Mie, Bandres-Ciga, Sara, Makarious, Mary B, Ojo, Oluwadamilola, Crea, Peter Wild, Abiodun, Oladunni, Levine, Kristin S, Abubakar, Sani, Achoru, Charles, Vitale, Dan, Adeniji, Olaleye, Agabi, Osigwe, Koretsky, Mathew J, Agulanna, Uchechi, Hall, Deborah A., Akinyemi, Rufus, Xie, Tao, Ali, Mohammed, Shamim, Ejaz A., Ani-Osheku, Ifeyinwa, Padmanaban, Mahesh, Arigbodi, Owotemu, Standaert, David G, Bello, Abiodun, Dean, Marissa, Erameh, Cyril, Elsayed, Inas, Farombi, Temitope, Okunoye, Olaitan, Fawale, Michael, Billingsley, Kimberley J, Imarhiagbe, Frank, Jerez, Pilar Alvarez, Iwuozo, Emmanuel, Baker, Breeana, Komolafe, Morenikeji, Malik, Laksh, Nwani, Paul, Daida, Kensuke, Nwazor, Ernest, Miano-Burkhardt, Abigail, Nyandaiti, Yakub, Fang, Zih-Hua, Obiabo, Yahaya, Kluss, Jillian H., Odeniyi, Olanike, Hernandez, Dena, Odiase, Francis, Tayebi, Nahid, Ojini, Francis, Sidranksy, Ellen, Onwuegbuzie, Gerald, D’Souza, Andrea M., Osaigbovo, Godwin, Berhe, Bahafta, Osemwegie, Nosakhare, Reed, Xylena, Oshinaike, Olajumoke, Leonard, Hampton, Otubogun, Folajimi, Alvarado, Chelsea X, Oyakhire, Shyngle, Ozomma, Simon, Samuel, Sarah, Taiwo, Funmilola, Wahab, Kolawole, Zubair, Yusuf, Iwaki, Hirotaka, Kim, Jonggeol Jeffrey, Morris, Huw R, Hardy, John, Nalls, Mike, Heilbron, Karl, Norcliffe-Kaufmann, Lucy, Blauwendraat, Cornelis, Houlden, Henry, Singleton, Andrew, and Okubadejo, Njideka

Subjects
Article
Abstract

BACKGROUND: Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards the realization of the global application of precision medicine. The African and African admixed populations enable mapping of complex traits given their greater levels of genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. METHODS: Here we perform a comprehensive genome-wide assessment of Parkinson’s disease (PD) in 197,918 individuals (1,488 cases; 196,430 controls) of African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding and structural genetic variation and polygenic risk profiling. FINDINGS: We identified a novel common risk factor for PD and age at onset at the GBA1 locus (risk, rs3115534-G; OR=1.58, 95% CI = 1.37 – 1.80, P=2.397E-14; age at onset, BETA =−2.004, SE =0.57, P = 0.0005), that was found to be rare in non-African/African admixed populations. Downstream short- and long-read whole genome sequencing analyses did not reveal any coding or structural variant underlying the GWAS signal. However, we identified that this signal mediates PD risk via expression quantitative trait locus (eQTL) mechanisms. While previously identified GBA1 associated disease risk variants are coding mutations, here we suggest a novel functional mechanism consistent with a trend in decreasing glucocerebrosidase activity levels. Given the high population frequency of the underlying signal and the phenotypic characteristics of the homozygous carriers, we hypothesize that this variant may not cause Gaucher disease. Additionally, the prevalence of Gaucher’s disease in Africa is low. INTERPRETATION: The present study identifies a novel African-ancestry genetic risk factor in GBA1 as a major mechanistic basis of PD in the African and African admixed populations. This striking result contrasts to previous work in Northern European populations, both in terms of mechanism and attributable risk. This finding highlights the importance of understanding population-specific genetic risk in complex diseases, a particularly crucial point as the field moves toward precision medicine in PD clinical trials and while recognizing the need for equitable inclusion of ancestrally diverse groups in such trials. Given the distinctive genetics of these underrepresented populations, their inclusion represents a valuable step towards insights into novel genetic determinants underlying PD etiology. This opens new avenues towards RNA-based and other therapeutic strategies aimed at reducing lifetime risk.

Published
2023

44. Carotid and Vertebral Atherosclerosis in West African Stroke Patients: Findings from the Stroke Investigative Research and Education Network

Author

Aridegbe, Mayowa, Fawale, Michael, Olowookere, Samuel, Imoh, Lucius, Adeleye, Osi, Efidi, Richard, Tiwari, Hemant, Mensah, Yaw, Calys-Tagoe, Benedict, Akintunde, Adeseye, Ogunjimi, Luqman, Olugbo, Obiabo, Egberongbe, Adedeji, Abdullahi, Muhammad, Sumonu, Taofiki, Sanni, Taofeek, Ogah, Okechukwu, Adeoye, Abiodun, Uvere, Ezinne, Ibinaiye, Philip, Akinyemi, Rufus, Ovbiagele, Bruce, Owolabi, Mayowa, Osaigbovo, Godwin, Ogbole, Godwin, Agunloye, Atinuke, Akinyemi, Joshua, Akpalu, Albert, Sarfo, Fred, Akpa, Onoja, Gebregziabher, Mulugeta, Arulogun, Oyedunni, Komolafe, Morenikeji, Wahab, Kolawole, Jenkins, Carolyn, Omisore, Adeleye, Obiako, Reginald, Owolab, Luqman, Fakunle, Adekunle, Ikubor, Joyce, Salaam, Abdul, Famurewa, Olusola, Adebayo, Oladimeji, Asaleye, Christianah, Akisanya, Cynthia, and Olabinri, Eunice

Subjects
Stroke, Carotid, Vertebral, Atherosclerosis, West Africa
Abstract

Background: We evaluated the characteristics of carotid and vertebral atherosclerosis in indigenous West Africans with stroke. Methodology: Of the 3778 stroke patients recruited between 01/2014 and 08/2017, 1070 (28.3%) received carotid and vertebral artery evaluation with B-mode Ultrasound. Carotid and vertebral intima-media thickness (IMT) using multiple site technique were measured bilaterally and plaque frequency was determined. Descriptive and comparative analyses between stroke types and vessels were carried out. Results: There were 809 (75.6%) patients with ischemic stroke. The prevalence of intima-media thickening in the study population was 84.0% (898/1070) [95% CI: 81.7-86.1], being higher in the ischemic stroke (688/809, 85.0%) [95% CI: 82.4-87.3] than in the hemorrhagic stroke group (211/261, 80.8%) [95% CI: 75.6-85.2]. Overall prevalence of plaques which was 26.1% [95% CI: 23.5-28.8], was found also to be higher in ischemic than hemorrhagic stroke (29.8% [95% CI: 26.7-33.0] vs. 14.6% [95% CI: 10.8-19.4], p < 0.05). The mean IMT (carotids: 2.01+1.33 mm; vertebrals: 0.96+0.54mm, p < 0.001) and prevalence of plaques (carotids: 8.8%; vertebrals: 1.7%, p < 0.001) were higher in carotid than vertebral arteries. Age, hypertension, level of formal education, history of smoking, average monthly income, and family histories of hypertension and stroke were associated with intima-media thickening in the carotids (all p < 0.05) in the ischemic stroke patients while family history of hypertension, diabetes mellitus, and level of formal education were independently associated with intima-media thickening in the carotids (all p < 0.05) in the hemorrhagic stroke patients. No CVRF showed an independent association with the presence of plaque in the carotid and vertebral arteries both stroke types. Conclusions: One of four stroke patients in our cohort had atherosclerotic plaques, with ischemic patients being twice as likely to have this burden compared to hemorrhagic patients, and carotid atherosclerosis being five times as frequent as vertebral atherosclerosis. &nbsp

Published
2023

45. Differential Impact of Risk Factors on Stroke Occurrence Among Men Versus Women in West Africa: The SIREN Study

Author

Akpalu, Albert, Gebregziabher, Mulugeta, Ovbiagele, Bruce, Sarfo, Fred, Iheonye, Henry, Akinyemi, Rufus, Akpa, Onoja, Tiwari, Hemant K., Arnett, Donna, Wahab, Kolawole, Lackland, Daniel, Abiodun, Adeoye, Ogbole, Godwin, Jenkins, Carolyn, Arulogun, Oyedunni, Akpalu, Josephine, Obiako, Reginald, Olowoyo, Paul, Fawale, Michael, Komolafe, Morenikeji, Osaigbovo, Godwin, Obiabo, Yahaya, Chukwuonye, Innocent, Owolabi, Lukman, Adebayo, Philip, Sunmonu, Taofiki, and Owolabi, Mayowa

Published
2019
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46. Intensive care management of sniper (organophosphate) poisoning secondary to deliberate self-harm: A case report.

Author

Ajayeoba, Olumuyiwa, Olateju, Simeon, Aaron, Olurotimi, Faponle, Aramide, Komolafe, Morenikeji, Adebowale, Akintunde, and Adesanmi, Akinsulore

Subjects
SUICIDE risk factors, INTENSIVE care units, ORGANOPHOSPHORUS compounds, INSECTICIDES, ATROPINE, AIRWAY (Anatomy), LOSS of consciousness, GLYCOPYRROLATE, PHENYTOIN, RISK assessment, VOMITING, ARTIFICIAL respiration, TREATMENT effectiveness, MEDICAL case management, RESPIRATORY distress syndrome, MIDAZOLAM, DISEASE complications, SELF-mutilation
Abstract

Sniper, an insecticide made of synthetic organophosphate, is a choice substance used for suicide in Nigeria among the youth due to its ready availability. The aim of this study was to describe the management of a case of organophosphate poisoning. A 24-year-old male medical student presented on account of loss of consciousness for 2 h, with vomiting, the passage of loose stool, and a preceding history of suicidal ideation. He was found in his room with an empty bottle of sniper. The patient was in obvious respiratory distress with excessive salivation. His baseline vital sign was as follows: pulse rate-124 bpm, blood pressure-150/80 mmHg, respiratory rate of 34 cpm, SpO2 86%, and temperature of 36.8°C. He was intubated, admitted into the intensive care unit, and placed on a mechanical ventilator. He was commenced on intravenous (IV) atropine 2 mg stat and IV glycopyrrolate 0.4 mg 8 hourly. On the 4th day, he was placed on IV atropine infusion 1 mg/h, while IV phenytoin 300 mg stat and then 150 mg nocte were commenced on account of provoked seizure. The patient had the IV atropine infusion for 10 days. He was placed on midazolam infusion for sedation and had potassium and magnesium correction. The patient was subsequently extubated, transferred to the ward, and discharged home after 10 days in the ward. Organophosphate poisoning management could be challenging and fatal. Early presentation, prompt and appropriate airway management, use of atropine infusion, prompt use of antibiotics, and other supportive care can improve survival. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Assessment of sleep knowledge among medical and dental students in a Nigerian tertiary institution: a cross-sectional study

Author

Olorunmoteni, Oluwatosin E., primary, Ogundipe, Olufemi K., additional, Sanusi, Ahmad Abefe, additional, Kolawole, Kikelomo Adebanke, additional, Fawale, Michael Bimbola, additional, Adebowale, Akintunde Adeolu, additional, Idowu, Ahmed Omokayode, additional, Eziyi, Josephine Eniola A., additional, Mosaku, Kolawole S., additional, Amusa, Yemisi Bola, additional, and Komolafe, Morenikeji Adeyoyin, additional

Published
2022
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49. Secondhand smoke exposure is independently associated with stroke among non-smoking adults in West Africa

Author

Okekunle, Akinkunmi Paul, primary, Asowata, Osahon Jeffery, additional, Fakunle, Adekunle G., additional, Akpa, Onoja Matthew, additional, Sarfo, Fred S., additional, Akpalu, Albert, additional, Wahab, Kolawole, additional, Obiako, Reginald, additional, Komolafe, Morenikeji, additional, Owolabi, Lukman, additional, Osaigbovo, Godwin O., additional, Tiwari, Hemant K., additional, Akinyemi, Joshua, additional, Jenkins, Carolyn, additional, Arulogun, Oyedunni, additional, Ibinaiye, Philip, additional, Appiah, Lambert, additional, Agunloye, Atinuke M., additional, Adeoye, Abiodun M., additional, Yaria, Joseph, additional, Calys-Tagoe, Benedict, additional, Uvere, Ezinne O., additional, Ogbole, Godwin, additional, Agyekum, Francis, additional, Sanni, Taofeek A., additional, Amusa, Ganiyu A., additional, Ogunronbi, Mayowa, additional, Olowookere, Samuel, additional, Balogun, Olayemi, additional, Ogunmodede, James A., additional, Olalusi, Oladotun V., additional, Samuel, Diala, additional, Mande, Aliyu, additional, Rabiu, Musbahu, additional, Adebayo, Philip, additional, Sunday, Adeniyi, additional, Imoh, Lucius Chidiebere, additional, Oguntade, Ayodipupo S., additional, Ajose, Abiodun, additional, Singh, Arti, additional, Adeegbe, Oluwayemisi T., additional, Mensah, Yaw, additional, Fawale, Michael B., additional, Abdul, Salaam, additional, Ikubor, Joyce, additional, Tolulope, Afolaranmi, additional, Yahaya, Isah S., additional, Akisanya, Cynthia, additional, Odo, Chidi J., additional, Efidi, Richard, additional, Chukwuonye, Innocent I., additional, Shidali, Vincent, additional, Adebowale, Akintunde, additional, Ohagwu, Kenneth A., additional, Adeleye, Osimhiarherhuo O., additional, Iheonye, Henry, additional, Akintunde, Adeseye, additional, Olabinri, Eunice, additional, Akpalu, Josephine, additional, Adesina, Julius, additional, Onyeonoro, Ugochukwu, additional, Onasanya, Akinola, additional, Arnett, Donna K., additional, Lackland, Daniel, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional

Published
2022
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50. PREVALENCE AND RISK FACTORS OF STROKE RECURRENCE IN GHANA AND NIGERIA

Author

Asowata, Osahon Jeffery, Sarfo, Fred Stephen, Akpa, Onoja Matthew, Akinyemi, Joshua, Okekunle, Akinkunmi Paul, Fakunle, Adekunle G., Ogbole, Godwin, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Osaigbovo, Godwin, Owolabi, Lukman, Akinyemi, Rufus, Owolabi, Mayowa, and Ovbiagele, Bruce

Published
2023
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