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Morphological structure of bone tissue was studied in various types of congenital deformations of the jaws. Morphological changes in the bone with deformations and the severity of these disorders depended not so much on the type on the deformation, but mainly on its severity, which can be explained by a drastic increase of functional exercise because of impaired occlusion and impossibility of proper chewing. Decelerated weak restructuring of bone tissue and imperfect osteogenesis in deformed bone, similar in various types of deformations, were demonstrated on morphological material. These changes can affect the regenerative potential of the bone in operated zones.

Periodontal reactions and the apexification process in the teeth with open apex of the root in response to different filling materials and the relationship between these processes and the quality of filling of the root channels were studied in experiments. Zinc-eugenol paste, intradont, itradont-D and intradont with lysozyme were used to fill the root channels in puppies aged 6-7 months. Filling of the root channel up to the apex was found to be the optimal variant, preventing the development of necrosis and promoting periodontal tissue regeneration.

Infectious toxic shock, acute renal and acute hepatorenal insufficiency are the principal morphoclinical syndromes in malignant forms of icterohemorrhagic leptospirosis. The major complications of acute renal and hepatorenal failure are pyoseptic involvements of the lungs, heart, and pancreas. Direct or indirect signs of the DIC syndrome and intravascular platelet aggregation are characteristic of all the principal clinical syndromes of malignant forms of leptospirosis.