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Markerless motion capture offers several benefits over traditional marker-based systems by eliminating the need for physical markers, which are prone to misplacement and artifacts. Utilizing computer vision and deep learning algorithms, markerless systems can directly detect human body landmarks, reducing manual processing and errors associated with marker placement. These systems are adaptable, able to track user-defined features, and practical for real-world applications using consumer-grade devices such as smartphone cameras. This study compares the performance of OpenCap, a markerless motion capture system, with traditional marker-based systems in assessing cycling biomechanics. Ten healthy adults participated in experiments to capture sagittal hip, knee, and ankle kinematics and dynamics using both methods. OpenCap used videos from smartphones and integrated computer vision and musculoskeletal simulations to estimate 3D kinematics. Results showed high agreement between the two systems, with no significant differences in kinematic and kinetic measurements for the hip, knee, and ankle. The correlation coefficients exceeded 0.98, indicating very strong consistency. Errors were minimal, with kinematic errors under 4 degrees and kinetic errors below 5 Nm. This study concludes that OpenCap is a viable alternative to marker-based motion capture, offering comparable precision without extensive setup for hip (flexion/extension), knee (flexion/extension), and ankle (dorsiflexion/plantarflexion) joints. Future work should aim to enhance the accuracy of ankle joint measurements and extend analyses to 3D kinematics and kinetics for comprehensive biomechanical assessments.

Simulation studies, such as finite element (FE) modeling, offer insights into knee joint biomechanics, which may not be achieved through experimental methods without direct involvement of patients. While generic FE models have been used to predict tissue biomechanics, they overlook variations in population-specific geometry, loading, and material properties. In contrast, subject-specific models account for these factors, delivering enhanced predictive precision but requiring significant effort and time for development. This study aimed to facilitate subject-specific knee joint FE modeling by integrating an automated cartilage segmentation algorithm using a 3D Swin UNETR. This algorithm provided initial segmentation of knee cartilage, followed by automated geometry filtering to refine surface roughness and continuity. In addition to the standard metrics of image segmentation performance, such as Dice similarity coefficient (DSC) and Hausdorff distance, the method's effectiveness was also assessed in FE simulation. Nine pairs of knee cartilage FE models, using manual and automated segmentation methods, were developed to compare the predicted stress and strain responses during gait. The automated segmentation achieved high Dice similarity coefficients of 89.4% for femoral and 85.1% for tibial cartilage, with a Hausdorff distance of 2.3 mm between the automated and manual segmentation. Mechanical results including maximum principal stress and strain, fluid pressure, fibril strain, and contact area showed no significant differences between the manual and automated FE models. These findings demonstrate the effectiveness of the proposed automated segmentation method in creating accurate knee joint FE models., Comment: arXiv admin note: substantial text overlap with arXiv:2312.00169

Simulation studies like finite element (FE) modeling provide insight into knee joint mechanics without patient experimentation. Generic FE models represent biomechanical behavior of the tissue by overlooking variations in geometry, loading, and material properties of a population. On the other hand, subject-specific models include these specifics, resulting in enhanced predictive precision. However, creating such models is laborious and time-intensive. The present study aimed to enhance subject-specific knee joint FE modeling by incorporating a semi-automated segmentation algorithm. This segmentation was a 3D Swin UNETR for an initial segmentation of the femur and tibia, followed by a statistical shape model (SSM) adjustment to improve surface roughness and continuity. Five hundred and seven magnetic resonance images (MRIs) from the Osteoarthritis Initiative (OAI) database were used to build and validate the segmentation model. A semi-automated FE model was developed using this semi-automated segmentation. On the other hand, a manual FE model was developed through manual segmentation (i.e., the gold standard approach). Both FE models were subjected to gait loading. The predicted mechanical response of manual and semi-automated FE models were compared. In the result, our semi-automated segmentation achieved Dice similarity coefficient (DSC) over 98% for both femur and tibia. The mechanical results (max principal stress, max principal strain, fluid pressure, fibril strain, and contact area) showed no significant differences between the manual and semi-automated FE models, indicating the effectiveness of the proposed semi-automated segmentation in creating accurate knee joint FE models. ( https://data.mendeley.com/datasets/k5hdc9cz7w/1 ).

Purpose: Thoracic radiographs are commonly used to evaluate patients with confirmed or suspected thoracic pathology. Proper patient positioning is more challenging in canine and feline radiography than in humans due to less patient cooperation and body shape variation. Improper patient positioning during radiograph acquisition has the potential to lead to a misdiagnosis. Asymmetrical hemithoraces are one of the indications of obliquity for which we propose an automatic classification method. Approach: We propose a hemithoraces segmentation method based on Convolutional Neural Networks (CNNs) and active contours. We utilized the U-Net model to segment the ribs and spine and then utilized active contours to find left and right hemithoraces. We then extracted features from the left and right hemithoraces to train an ensemble classifier which includes Support Vector Machine, Gradient Boosting and Multi-Layer Perceptron. Five-fold cross-validation was used, thorax segmentation was evaluated by Intersection over Union (IoU), and symmetry classification was evaluated using Precision, Recall, Area under Curve and F1 score. Results: Classification of symmetry for 900 radiographs reported an F1 score of 82.8% . To test the robustness of the proposed thorax segmentation method to underexposure and overexposure, we synthetically corrupted properly exposed radiographs and evaluated results using IoU. The results showed that the models IoU for underexposure and overexposure dropped by 2.1% and 1.2%, respectively. Conclusions: Our results indicate that the proposed thorax segmentation method is robust to poor exposure radiographs. The proposed thorax segmentation method can be applied to human radiography with minimal changes., Comment: Submitted to SPIE Journal of Medical Imaging