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Your search keyword '"Komatsu, Shoko"' showing total 27 results
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27 results on '"Komatsu, Shoko"'

6. Investigation of a Legionella pneumophila Outbreak at a Bath Facility in Japan Using Whole-Genome Sequencing of Isolates from Clinical and Environmental Samples.

Author

Nakanishi, Noriko, Komatsu, Shoko, Tanaka, Shinobu, Mukai, Kengo, and Nomoto, Ryohei

Subjects
LEGIONELLA pneumophila, LEGIONNAIRES' disease, ENVIRONMENTAL sampling, NUCLEOTIDE sequencing
Abstract

Exposure to aerosols containing Legionella from artificially made water systems has been established as a primary cause of Legionnaires' disease. In this study, we investigated an outbreak of L. pneumophila serogroup 1 sequence type 138 which occurred at a bath facility in 2022. The whole-genome sequencing of isolates revealed that the colonization of L. pneumophila at the bath facility had occurred before 2013, and the patients had been exposed to multiple genetic lineages of the strain. Our study demonstrates the importance of performing a careful comparative genetic analysis of clinical and environmental isolates from LD outbreaks in order to effectively investigate and prevent future LD outbreaks. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Long-term consumption of non-fermented and fermented dairy products and risk of breast cancer by estrogen receptor status - Population-based prospective cohort study.

Author

Kaluza, Joanna, Komatsu, Shoko, Lauriola, Mara, Harris, Holly R, Bergkvist, Leif, Michaëlsson, Karl, Wolk, Alicja, Kaluza, Joanna, Komatsu, Shoko, Lauriola, Mara, Harris, Holly R, Bergkvist, Leif, Michaëlsson, Karl, and Wolk, Alicja

Abstract

BACKGROUND & AIMS: The impact of dairy consumption on breast cancer development is unclear. We sought to examine associations between long-term consumption of milk and fermented dairy products and risk of breast cancer by estrogen (ER) and progesterone receptor (PR) status and assess whether these associations varied by body weight. METHODS: The population-based Swedish Mammography Cohort included 33,780 women (88.2% postmenopausal), with no history of cancer or diabetes at baseline (1997). Long-term consumption of dairy products was assessed using a self-administered food-frequency questionnaire in 1987 and 1997. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: During 16.6 years of follow-up (559,286 person-years), 1870 total breast cancer cases were diagnosed (1162 ER+/PR+; 195 ER-/PR-). High long-term non-fermented milk consumption was associated with increased ER+/PR+ breast cancer incidence, HR = 1.30, 95%CI:1.02-1.65 for the average of 1987 and 1997 intake ≥2 vs. 0 servings/day and this increased risk was limited to women with BMI<25 kg/m2 HR = 1.55, 95%CI:1.08-2.21, while no significant associations with milk consumption were observed with ER-/PR- breast cancer. In contrast, consumption of fermented dairy products was inversely associated with ER-/PR- breast cancer (for consistently high intake ≥3 vs. <1 servings/day HR = 0.28, 95%CI:0.10-0.78), but not clear association was observed for ER+/PR+ (HR = 0.89, 95%CI:0.69-1.14). CONCLUSIONS: In this cohort of mainly postmenopausal women, high long-term consumption of milk was associated with increased risk of ER+/PR+ breast cancer. In contrast, high long-term consumption of fermented dairy products was associated with decreased risk of ER-/PR- breast cancer.

Published
2020
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11. Green tea and the risk of gastric cancer in Japan

Author

Tsubono, Yoshitaka, Nishino, Yoshikazu, Komatsu, Shoko, Hsieh, Chung-Cheng, Kanemura, Seiki, Tsuji, Ichiro, Nakatsuka, Haruo, Fukao, Akira, Satoh, Hiroshi, and Hisamichi, Shigeru

Subjects
Tea -- Health aspects, Stomach cancer -- Prevention, Japanese -- Diseases
Abstract

The consumption of green tea does not protect against stomach cancer nor does it increase the risk of stomach cancer. This was the conclusion of Japanese researchers who followed 26,311 people for nine years.

Published
2001

15. Genome- and Mass Spectrometry-Guided Discovery of Ralstoamides A and B from Ralstonia solanacearumSpecies Complex

Author

Komatsu, Shoko, Tsumori, Chiaki, Ohnishi, Kouhei, and Kai, Kenji

Abstract

Strains of Ralstonia solanacearumspecies complex (RSSC) are devastating plant pathogens distributed globally with a wide host range and genetic diversity. Many RSSC strains harbor the polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) hybrid gene rmyA/rmyBfor ralstonin production. We report that ralstoamides A (1) and B (2), which are ralstonin-like but shorter lipopeptides, were discovered from the Japanese strains using accumulated RSSC genome data and LC/MS-based metabolite analysis. Their structures, including absolute configurations, were elucidated by spectroscopic analysis and chemical techniques. ramA, a PKS-NRPS gene for ralstoamide production, was identified from the producer strains by genome sequencing and gene-deletion experiments. Based on the analysis of biosynthetic genes of ralstoamides and ralstonins, we suggest the occurrence of NRPS-module reduction of rmyA/rmyBgenes in some RSSC strains. This possible molecular evolution changed not only the structures, but also the biological activity of RSSC lipopeptides.

Published
2020
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18. A Cohort Study on the Relation of Lifestyle, Personality and Biologic Markers to Cancer in Miyagi, Japan : Study Design, Response Rate and Profiles of the Cohort Subjects

Author

Fukao, Akira, primary, Tsubono, Yoshitaka, additional, Komatsu, Shoko, additional, Tsuji, Ichiro, additional, Minami, Yuko, additional, Hisamichi, Shigeru, additional, Hosokawa, Toru, additional, Kawamura, Mieko, additional, Takano, Akira, additional, Sugahara, Nobuyuki, additional, Ikeda, Takashi, additional, and Nishikori, Mitsuaki, additional

Published
1995
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22. Comparison of Characteristics between Frequent Participants and Non-Participants in Screening Program for Stomach Cancer.

Author

FUKAO, AKIRA, primary, HISAMICHI, SHIGERU, additional, KOMATSU, SHOKO, additional, SHIMIZU, HIROYUKI, additional, SATOH, HIROSHI, additional, NAKATSUKA, HARUO, additional, WATANABE, TAKAO, additional, FUJISAKU, SUSUMU, additional, ICHINOWATARI, YOSHIMI, additional, KURODA, SATORU, additional, IDA, YASUO, additional, SUDA, SEIKI, additional, KATO, KUNIO, additional, and IKEDA, MASAYUKI, additional

Published
1992
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25. The Independent Association of Smoking and Drinking with Serum {beta}-Carotene Levels among Males in Miyagi, Japan

Author

FUKAO, AKIRA, TSUBONO, YOSHITAKA, KAWAMURA, MIEKO, IDO, TATSUO, AKAZAWA, NORIKO, TSUJI, ICHIRO, KOMATSU, SHOKO, MINAMI, YUKO, and HISAMICHI, SHIGERU

Abstract

Background Previous studies indicated that serum β-carotene levels were low among smokers and drinkers. However these findings may result from the strong relationship between smoking and drinking. Methods Data were collected from 1902 males randomly selected from participants of a cohort study. The effects of smoking on serum β-carotene levels were assessed according to drinking status (non-drinker, ex-drinker and current drinker), and those of drinking were assessed according to smoking status (non-smoker, ex-smoker and current smoker) using general linear model including other factors (age, intake of green-yellow vegetables, intake of carrot or pumpkin, body mass index, serum cholesterol levels). Results An inverse dose-response relationship between daily consumption of alcohol and β-carotene levels was observed regardless of smoking status, and also between number of cigarettes smoked per day and β-carotene levels regardless of drinking status. Conclusions These results suggest that cigarette smoking and alcohol drinking reduce β-carotene levels independently.

Published
1996
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26. Complete genome sequences of Escherichia coli KA0011 clinical isolate used as a quality control strain of carbapenem susceptibility testing in Japan.

Author

Nomoto R, Nakanishi N, Komatsu S, Matsui M, and Suzuki S

Abstract

Escherichia coli KA0011 had stable minimum inhibitory concentration values around the breakpoint range of meropenem and imipenem, making it suitable for use as a quality control strain for antimicrobial susceptibility testing. Here, we report the complete genomic sequence of KA0011., Competing Interests: The authors declare no conflict of interest.

Published
2024
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27. Prevalence and genetic distribution of Legionella spp. in public bath facilities in Kobe City, Japan.

Author

Komatsu S, Tanaka S, and Nakanishi N

Subjects
Humans, Japan epidemiology, Prevalence, Water Microbiology, Legionella pneumophila genetics, Legionella genetics, Legionellosis epidemiology
Abstract

Legionella is an important waterborne pathogen that causes legionellosis. Public baths are considered the primary cause of legionellosis infection in Japan. We investigated the prevalence and genetic distribution of 338 Legionella spp. isolates from 81 public bath facilities, including 35 hot springs and 46 other facilities, through annual periodic surveillance in Kobe, Japan, from 2016 to 2021. In addition, the genotypes of nine clinical strains of unknown infectious source from the same period were compared to those of bathwater isolates. We elucidated the differences in the distribution of Legionella species, serogroups, and genotypes between hot springs and other public baths. Legionella israelensis, L. londiniensis, and L. micdadei colonized hot springs along with L. pneumophila. The minimum spanning tree analysis based on multiple-locus variable number tandem repeat analysis (MLVA) also identified four major clonal complexes (CCs) in L. pneumophila SG1 and found that CC1 of the four CCs is a specific novel genotype with the lag-1 gene in hot springs. The same MLVA genotypes and sequence types as those of the clinical strains were not present among the strains isolated from bath water. Thus, our surveillance is useful for estimating the sources of legionellosis infection in Japan and developing prevention strategies.

Published
2023
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