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1. Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial

Author

Basso, AC, Bonvehi, P, Cerana, S, Dictar, MO, Campbell, P, Playford, G, Sasadeusz, J, Maertens, J, Poire, X, Sellesag, D, Schots, R, Theunissen, K, Willems, E, Alves, RS, Camargo, JFC, Castro, NS, Maria Fogliatto, L, Rodrigo, O, Courture, F, McGeer, A, Miller, M, Combariza, JF, Sossa, CL, Velez, JD, Nemet, D, Ostojic Kolonic, S, Jebavy, L, Mayer, J, Novak, J, Pohlreich, D, Maldonado, B, Gastinne, T, Karlin, L, Launay, O, Cornely, OA, Duerk, HA, Haenel, M, Heinz, W, Kaufmann, M, Panse, J, Teschner, D, Verbeek, M, Wulf, G, Aviv, F, Grisariu, S, Nagler, A, Yeshurun, M, Bosi, A, Corradini, P, Martinelli, G, Onida, F, Rambaldi, A, Velardi, A, Trociukas, I, Gomez, AD, Wondergem, MJ, Ypma, PF, Fanilla, E, Moreno Larrea, MDC, Abecasis, MM, Ferreira, RB, Geraldes, C, Castro, J, Afanasyev, BV, Kruchkova, IV, Zaritskiy, AY, Cheong, JW, Kim, SJ, Lee, DG, Yoon, SS, Aguado Bueno, B, Jarque Ramos, I, Solano Vercet, C, Cherif, H, Ljungman, P, Vaht, K, Cook, G, Kanfer, E, Milligan, DW, Parker, A, Akard, L, Bachier, C, Ball, ED, Betts, FR, Braunschweig, I, Brown, JM, Carroll, MP, Chandrasekar, PH, Collins, R, Cooper, B, Craig, M, D'Cunha, N, Donato, ML, Essell, J, Flomenberg, P, Freifeld, A, Freytes, C, Guarino, MJ, Hall, MC, Heimenz, JW, High, KP, Isola, LM, Kaminer, L, Klein, LM, Janakiraman, N, Kane, K, Komanduri, K, Krijanovski, OI, Lawrence, SJ, Leis, JF, Lill, M, Longo, WL, Lynch, JP, Mattar, BI, Mehta, J, Mullane, KM, Nathan, S, Papanicolaou, GA, Pergam, SA, Roy, V, Rybka, W, Safah, H, Saltzman, D, Segal, GM, Selby, GB, Schuster, MW, Shoham, S, Sloan, JM, Strasfeld, LM, Styler, M, Sullivan, K, Tse, W, Vance, EA, Winston, DJ, Yanovich, S, Winston, Drew J, Mullane, Kathleen M, Cornely, Oliver A, Boeckh, Michael J, Brown, Janice Wes, Pergam, Steven A, Trociukas, Igoris, Žák, Pavel, Craig, Michael D, Papanicolaou, Genovefa A, Velez, Juan D, Panse, Jens, Hurtado, Kimberly, Fernsler, Doreen A, Stek, Jon E, Pang, Lei, Su, Shu-Chih, Zhao, Yanli, Chan, Ivan S F, Kaplan, Susan S, Parrino, Janie, Lee, Ingi, Popmihajlov, Zoran, Annunziato, Paula W, and Arvin, Ann

Published
2018
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11. Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial

Author

Winston, Drew J, primary, Mullane, Kathleen M, additional, Cornely, Oliver A, additional, Boeckh, Michael J, additional, Brown, Janice Wes, additional, Pergam, Steven A, additional, Trociukas, Igoris, additional, Žák, Pavel, additional, Craig, Michael D, additional, Papanicolaou, Genovefa A, additional, Velez, Juan D, additional, Panse, Jens, additional, Hurtado, Kimberly, additional, Fernsler, Doreen A, additional, Stek, Jon E, additional, Pang, Lei, additional, Su, Shu-Chih, additional, Zhao, Yanli, additional, Chan, Ivan S F, additional, Kaplan, Susan S, additional, Parrino, Janie, additional, Lee, Ingi, additional, Popmihajlov, Zoran, additional, Annunziato, Paula W, additional, Arvin, Ann, additional, Basso, AC, additional, Bonvehi, P, additional, Cerana, S, additional, Dictar, MO, additional, Campbell, P, additional, Playford, G, additional, Sasadeusz, J, additional, Maertens, J, additional, Poire, X, additional, Sellesag, D, additional, Schots, R, additional, Theunissen, K, additional, Willems, E, additional, Alves, RS, additional, Camargo, JFC, additional, Castro, NS, additional, Maria Fogliatto, L, additional, Rodrigo, O, additional, Courture, F, additional, McGeer, A, additional, Miller, M, additional, Combariza, JF, additional, Sossa, CL, additional, Velez, JD, additional, Nemet, D, additional, Ostojic Kolonic, S, additional, Jebavy, L, additional, Mayer, J, additional, Novak, J, additional, Pohlreich, D, additional, Maldonado, B, additional, Gastinne, T, additional, Karlin, L, additional, Launay, O, additional, Cornely, OA, additional, Duerk, HA, additional, Haenel, M, additional, Heinz, W, additional, Kaufmann, M, additional, Panse, J, additional, Teschner, D, additional, Verbeek, M, additional, Wulf, G, additional, Aviv, F, additional, Grisariu, S, additional, Nagler, A, additional, Yeshurun, M, additional, Bosi, A, additional, Corradini, P, additional, Martinelli, G, additional, Onida, F, additional, Rambaldi, A, additional, Velardi, A, additional, Trociukas, I, additional, Gomez, AD, additional, Wondergem, MJ, additional, Ypma, PF, additional, Fanilla, E, additional, Moreno Larrea, MDC, additional, Abecasis, MM, additional, Ferreira, RB, additional, Geraldes, C, additional, Castro, J, additional, Afanasyev, BV, additional, Kruchkova, IV, additional, Zaritskiy, AY, additional, Cheong, JW, additional, Kim, SJ, additional, Lee, DG, additional, Yoon, SS, additional, Aguado Bueno, B, additional, Jarque Ramos, I, additional, Solano Vercet, C, additional, Cherif, H, additional, Ljungman, P, additional, Vaht, K, additional, Cook, G, additional, Kanfer, E, additional, Milligan, DW, additional, Parker, A, additional, Akard, L, additional, Bachier, C, additional, Ball, ED, additional, Betts, FR, additional, Braunschweig, I, additional, Brown, JM, additional, Carroll, MP, additional, Chandrasekar, PH, additional, Collins, R, additional, Cooper, B, additional, Craig, M, additional, D'Cunha, N, additional, Donato, ML, additional, Essell, J, additional, Flomenberg, P, additional, Freifeld, A, additional, Freytes, C, additional, Guarino, MJ, additional, Hall, MC, additional, Heimenz, JW, additional, High, KP, additional, Isola, LM, additional, Kaminer, L, additional, Klein, LM, additional, Janakiraman, N, additional, Kane, K, additional, Komanduri, K, additional, Krijanovski, OI, additional, Lawrence, SJ, additional, Leis, JF, additional, Lill, M, additional, Longo, WL, additional, Lynch, JP, additional, Mattar, BI, additional, Mehta, J, additional, Mullane, KM, additional, Nathan, S, additional, Papanicolaou, GA, additional, Pergam, SA, additional, Roy, V, additional, Rybka, W, additional, Safah, H, additional, Saltzman, D, additional, Segal, GM, additional, Selby, GB, additional, Schuster, MW, additional, Shoham, S, additional, Sloan, JM, additional, Strasfeld, LM, additional, Styler, M, additional, Sullivan, K, additional, Tse, W, additional, Vance, EA, additional, Winston, DJ, additional, and Yanovich, S, additional

Published
2018
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12. PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies

Author

Qazilbash, M H, primary, Wieder, E, additional, Thall, P F, additional, Wang, X, additional, Rios, R, additional, Lu, S, additional, Kanodia, S, additional, Ruisaard, K E, additional, Giralt, S A, additional, Estey, E H, additional, Cortes, J, additional, Komanduri, K V, additional, Clise-Dwyer, K, additional, Alatrash, G, additional, Ma, Q, additional, Champlin, R E, additional, and Molldrem, J J, additional

Published
2016
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16. Double Cord Blood Transplantation (CBT) With Ex-Vivo Expansion (EXP) of One Unit Utilizing A Mesenchymal Stromal Cell (MSC) Platform

Author

de Lima, M., primary, McNiece, I., additional, McMannis, J., additional, Hosing, C., additional, Kebraei, P., additional, Komanduri, K., additional, Worth, L., additional, Staba, S., additional, Cooper, L., additional, Petropolous, D., additional, Lee, D., additional, Jones, R., additional, Nieto, Y., additional, Andersson, B., additional, Korbling, M., additional, Alousi, A., additional, Qazilbash, M., additional, Popat, U., additional, Khouri, I., additional, Bollard, C., additional, Leen, A., additional, Rondon, G., additional, Molldrem, J., additional, Champlin, R., additional, Simmons, P., additional, and Shpall, E., additional

Published
2009
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19. A Dose and Schedule Finding Study of Maintenance Therapy with Low-Dose 5-Azacitidine (AZA) after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for High-Risk AML or MDS.

Author

de Lima, Marcos, primary, Padua, L., additional, Giralt, S., additional, Hosing, C., additional, Komanduri, K., additional, Qazilbash, M., additional, Shpall, E.J., additional, Thall, P., additional, Qureshi, S., additional, McCormick, G., additional, Tong, W., additional, Popat, U., additional, Soriano, A., additional, Champlin, R., additional, and Garcia-Manero, G., additional

Published
2007
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20. Randomized Study of Double Cord Blood Transplantation (CBT) with Versus without Ex-Vivo Expansion (EXP).

Author

de Lima, Marcos, primary, McMannis, J., primary, Komanduri, K., primary, Worth, L., primary, Karandish, S., primary, Jones, R., primary, Giralt, S., primary, Cooper, L., primary, Padua, L., primary, Patah, P., primary, Petropoulos, D., primary, Thall, P., primary, Zhang, W., primary, Qiao, W., primary, Robinson, S., primary, Qureshi, S., primary, Khouri, I., primary, Hosing, C., primary, Alousi, A., primary, Rondon, G., primary, Andersson, B.S., primary, Champlin, R., primary, and Shpall, E.J., primary

Published
2007
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24. PR1 peptide vaccination for patients with myeloid leukemias

Author

Qazilbash, M. H., primary, Thall, P. F., additional, Wang, X., additional, Wieder, E., additional, Rios, R., additional, Kant, S., additional, Estey, E. H., additional, Cortes, J. E., additional, Komanduri, K., additional, Champlin, R. E., additional, and Molldrem, J. J., additional

Published
2007
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36. Transplantation of Cord Blood Expanded Ex Vivo with Copper Chelator.

Author

Shpall, E., primary, de Lima, M., additional, Chan, K., additional, Champlin, R., additional, Gee, A., additional, Thall, P., additional, Komanduri, K., additional, Couriel, D., additional, Andersson, B., additional, Hosing, C., additional, Giralt, S., additional, Karandish, S. Safa, additional, Sadeghi, T. Tara, additional, Muriera, B., additional, Peled, T., additional, Grynspan, F., additional, Nagler, A., additional, and McMannis, J., additional

Published
2004
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39. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study.

Author

de Lima M, Giralt S, Thall PF, de Padua Silva L, Jones RB, Komanduri K, Braun TM, Nguyen HQ, Champlin R, Garcia-Manero G, de Lima, Marcos, Giralt, Sergio, Thall, Peter F, de Padua Silva, Leandro, Jones, Roy B, Komanduri, Krishna, Braun, Thomas M, Nguyen, Hoang Q, Champlin, Richard, and Garcia-Manero, Guillermo

Abstract

Background: Recurrence is a major cause of treatment failure after allogeneic transplantation for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), and treatment options are very limited. Azacitidine is a DNA methyltransferase inhibitor with activity in myeloid disease. The authors hypothesized that low-dose azacitidine administered after transplant would reduce recurrence rates, and conducted a study to determine a safe dose/schedule combination.Methods: Forty-five high-risk patients were treated. Median age was 60 years; median number of comorbidities was 3; 67% were not in remission. By using a Bayesian adaptive method to determine the best dose/schedule combination based on time to toxicity, the authors investigated combinations of 5 daily azacitidine doses, 8, 16, 24, 32, and 40 mg/m2, and 4 schedules: 1, 2, 3, or 4 cycles, each with 5 days of drug and 25 days of rest. Cycle 1 started on Day +40.Results: Reversible thrombocytopenia was the dose-limiting toxicity. The optimal combination was 32 mg/m2 given for 4 cycles. Median follow-up was 20.5 months. One-year event-free and overall survival were 58% and 77%, justifying further studies to estimate long-term clinical benefit. No dose significantly affected DNA global methylation.Conclusions: Azacitidine at 32 mg/m2 given for 5 days is safe and can be administered after allogeneic transplant for at least 4 cycles to heavily pretreated AML/MDS patients. The trial also suggested that this treatment may prolong event-free and overall survival, and that more cycles may be associated with greater benefit. [ABSTRACT FROM AUTHOR]

Published
2010
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40. AML-loaded DC generate Th1-type cellular immune responses in vitro.

Author

Xing, D., Decker, W. K., Li, S., Robinson, S. N., Yang, H., Segal, H., O'Connor, S., Yao, X., Komanduri, K. V., McMannis, J. D., Jones, R. B., de Lima, M., Champlin, R. E., and Shpall, E. J.

Subjects
IMMUNE response, CELLULAR immunity, IMMUNITY, ACUTE myeloid leukemia, T cells, LYMPHOCYTES
Abstract

Background The generation of AML-specific T-lymphocyte responses by leukemia-derived DC has been documented by multiple investigators and is being pursued clinically. An obstacle to widespread use of this strategy is that it has not been possible to generate leukemic DC from all patients, and an alternative approach is needed if the majority of leukemia patients are to receive therapeutic vaccination in conjunction with other treatment protocols. Methods In the present study, we generated DC from CD14-selected monocytes isolated from healthy donor PBPC and loaded them with a total cell lysate from AML patient blasts. Results Immature in vitro -derived DC exhibited robust phagocytic activity, and mature DC demonstrated high expression of CD80, CD83, CD86 and the chemokine receptor CCR7, important for DC migration to local lymph nodes. Mature, Ag-loaded DC were used as APC for leukemia-specific cytotoxic T-lymphocyte (CTL) induction and demonstrated cytotoxic activity against leukemic targets. CTL lysis was Ag-specific, with killing of both allogeneic leukemic blasts and autologous DC loaded with allogeneic AML lysate. HLA-matched controls were not lysed in our system. Discussion These data support further research into the use of this strategy as an alternative approach to leukemia-derived DC vaccination. [ABSTRACT FROM AUTHOR]

Published
2006
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42. The Role of Transverse Axial Tomography in Three-Dimensional Treatment Planning

Author

Anam Sudarsanam, Pavel V. Houdek, Herbert Turnier, Komanduri K. Charyulu, and Fredie P. Gargano

Subjects
medicine.medical_specialty, Radiotherapy, Computers, Tomography, X-Ray, business.industry, Computation, Radiotherapy Dosage, Dose distribution, Patient Care Planning, Transverse plane, Axial tomography, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Radiation treatment planning
Abstract

The authors discuss the use of transverse axial tomography in target localization, treatment simulation, and computation of dose distribution, including three-dimensional display. This technique facilitates accurate and rapid treatment planning for the individual patient. Limitations encountered during the application of this method over a period of two years are described.

Published
1974
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43. Randomized study of local control and survival following radical surgery or radiation therapy in oral and laryngeal carcinomas

Author

Brace Hintz, Carlos Garciga, James R. Chandler, Anam Sudarsanam, and Komanduri K. Charyulu

Subjects
medicine.medical_specialty, Voice Quality, medicine.medical_treatment, Laryngectomy, law.invention, Radiotherapy, High-Energy, Randomized controlled trial, Swallowing, law, otorhinolaryngologic diseases, Humans, Medicine, Prospective Studies, Radical surgery, Prospective cohort study, Laryngeal Neoplasms, Mouth neoplasm, business.industry, General Medicine, Laryngeal Neoplasm, Deglutition, Surgery, Radiation therapy, Oncology, Carcinoma, Squamous Cell, Mouth Neoplasms, business, Follow-Up Studies
Abstract

From 1971 to 1975, 100 patients with glottic, supraglottic, and oral cavity lesions were prospectively randomized between primary radiation treatment and primary surgery. Local control and survival were similar with either treatment for lesions of the oral cavity or supraglottic larynx. Comparison between radiation alone and surgery alone for T1 and T2 glottic laryngeal lesions showed local control rates of 76% and 100% (P=0.32); after secondary salvage attempts, local control rates were 82% and 100%, respectively (P= 0.52). Neither result approached statistical significance. Successful radiation for early glottic larynx lesions resulted in superior deglutition and equivalent voice function compared to successful primary treatment with conservation laryngectomy. For oral cavity lesions, swallowing was impaired in the same percentage of radiated and operated patients, but fewer primary radiation patients had articulation difficulties. Among the patients with supraglottic larynx lesions, aspiration was not a problem with either radiation or surgery, but successful radiation perhaps maintained a slightly better voice quality.

Published
1979
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46. Metabolic control and compartmentation in single living cells

Author

Cahide Kohen, Alain W. Wouters, Komanduri K. N. Charyulu, Bo Thorell, Joseph G. Hirschberg, Hans V. Westerhoff, and Elli Kohen

Subjects
Clinical Biochemistry, Malates, Glucose-6-Phosphate, Biochemistry, Redox, Cofactor, Oxidative Phosphorylation, Cell Line, chemistry.chemical_compound, Mice, Adenosine Triphosphate, Flavins, Animals, Glycolysis, Cells, Cultured, Nicotinamide, biology, Glucosephosphates, Cell Biology, General Medicine, Metabolism, NAD, Cell Compartmentation, Mitochondria, Rats, Citric acid cycle, Adenosine Diphosphate, Spectrometry, Fluorescence, chemistry, biology.protein, Calcium, NAD+ kinase, Oxidation-Reduction, Intracellular, Mathematics, NADP
Abstract

Microspectrofluorometry of cell coenzymes (NAD(P)H, flavins) in conjunction with sequential microinjections into the same cell of metabolites and modifiers, reveals aspects of the regulatory mechanisms of transient redox changes of mitochondrial and extramitochondrial nicotinamide adenine dinucleotides. The injection of ADP in the course of an NAD(P)H transient produced by glycolytic (e.g. glucose 6-phosphate, G6P) or mitochondrial (e.g. malate) substrate leads to sharp reoxidation (state III, Chance and Williams, 1955), followed by a spontaneous state III to IV transition, and an ultimate return to original redox steady state. The response to ADP alone is biphasic, i.e. a small oxidation-reduction transient followed by a larger reverse transient. Similarities between responses to injected ATP and ADP suggest possible intracellular inter-conversions. Sequential injections of glycolytic and Krebs cycle substrates into the same cell, produce a two-step NAD(P) response, possibly revealing the intracellular compartmentation of this coenzyme. A two-step NAD(P)H response to sequentially injected fructose 1,6-diphosphate and G6P indicates the dynamic or even structural compartmentation of glycolytic phosphate esters in separate intracellular pools. The intracellular regulation and compartmentation of bioenergetic pathways and cell-to-cell metabolic inhomogeneities provide the basis on which the quantitative biochemistry of the intact living cell may be reconciled with these in situ findings.

Published
1983

47. Transverse axial tomography of the cervical spine

Author

Fredie P. Gargano, Pavel V. Houdek, John D. Meyer, and Komanduri K. Charyulu

Subjects
musculoskeletal diseases, medicine.medical_specialty, Radiography, Posture, Lumbar vertebrae, Radiation Dosage, Axial tomography, medicine, Humans, Radiology, Nuclear Medicine and imaging, Spinal canal, Lumbar Vertebrae, Spinal Neoplasms, business.industry, Tomography, X-Ray, musculoskeletal system, Foreign Bodies, respiratory tract diseases, Cross section (geometry), Transverse plane, medicine.anatomical_structure, Cervical Vertebrae, Spinal Diseases, Tomography, Radiology, business, Nuclear medicine, Meningioma, Spinal Canal, Cervical vertebrae
Abstract

Transverse axial tomography of the spine is a radiographic technique in which one can portray any level of the spine in cross section in the living patient. The examination provides a nondistorted magnified axial view of a preselected area of the spine and is a valuable adjunct to standard radiographic techniques.

Published
1974

48. Randomized study of control of the primary tumor and survival using preoperative radiation, radiation alone, or surgery alone in head and neck carcinomas

Author

Brace Hintz, Anam Sudarsanam, James R. Chandler, Carlos Garciga, and Komanduri K. Charyulu

Subjects
medicine.medical_specialty, medicine.medical_treatment, Laryngectomy, law.invention, Radiotherapy, High-Energy, Postoperative Complications, Randomized controlled trial, Preoperative radiation, law, medicine, Humans, In patient, Prospective Studies, Head and neck, Survival analysis, business.industry, Treatment regimen, Glossectomy, General Medicine, medicine.disease, Primary tumor, Surgery, Radiation therapy, Oncology, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Neck Dissection, business
Abstract

Fifty-five selected patients with previously untreated squamous cell carcinoma of the head and neck regions were studied in a randomized, prospective manner. The three treatment categories were primary radiation (Gp R), primary surgery (Gp S), and preoperative radiation of 4000 rads in four weeks (Gp R/S). The local control rates for the 44 evaluable patients with a two-year minimum followup were 24%, 39%, and 43%, respectively. Further treatment attempts in patients failing initial therapy yielded local control rates of 35%, 39%, and 43% for Gp R, Gp S, and Gp R/S, respectively. None of the local control rates nor the corresponding survival curves were significantly different at P < 0.10. However, the group sizes were sufficiently small that true differences might not have been detected. Postoperative complications were higher in the primary radiation failures subsequently operated upon compared to the primary surgery group (P = 0.07). A table is included in which the types of postoperative complications are listed and enumerated according to treatment regime.

Published
1979

49. Electron and x-ray beam characteristics of the linac LMR-13

Author

Anam Sudarsanam, Komanduri K. Charyulu, Pavel V. Houdek, and Ananda Rao

Subjects
Physics, Scattering, Electrons, Radiotherapy Dosage, Electron, Penetration (firestop), X ray beam, Radiation Dosage, Linear particle accelerator, Flattening, Radiotherapy, High-Energy, Physics::Accelerator Physics, Scattering, Radiation, Radiology, Nuclear Medicine and imaging, Atomic physics, Depth dose, Beam (structure)
Abstract

Electron beams of nominal energies 4, 8, 10 and 12 MeV were investigated. The effect of Ni and Pb scattering foils on beam penetration and field flatness is discussed and optimal combinations of beam energies and scattering foils are suggested. Depth doses are expressed as percentiles. A study of the 10 MV x-ray beam shows a need for two flattening filters for clinical ranges of field sizes. Flatness and depth dose data variations for two lead flattening filters of the same maximum thickness and central axis percentage depth doses are given.

Published
1974

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