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435 results on '"Kolossváry, Márton"'

2. Biological and Clinical Implications of the Vascular Endothelial Growth Factor Coreceptor Neuropilin-1 in Human Immunodeficiency Virus

Author

Schnittman, Samuel R, Kolossváry, Márton, Beck-Engeser, Gabriele, Fitch, Kathleen V, Ambayec, Gabrielle C, Nance, Robin M, Zanni, Markella V, Diggs, Marissa, Chan, Fay, McCallum, Sara, Toribio, Mabel, Bamford, Laura, Fichtenbaum, Carl J, Eron, Joseph J, Jacobson, Jeffrey M, Mayer, Kenneth H, Malvestutto, Carlos, Bloomfield, Gerald S, Moore, Richard D, Umbleja, Triin, Saag, Michael S, Aberg, Judith A, Currier, Judith S, Delaney, Joseph AC, Martin, Jeffrey N, Lu, Michael T, Douglas, Pamela S, Ribaudo, Heather J, Crane, Heidi M, Hunt, Peter W, and Grinspoon, Steven K

Subjects
Biomedical and Clinical Sciences, Immunology, Heart Disease, HIV/AIDS, Infectious Diseases, Aging, Sexually Transmitted Infections, Heart Disease - Coronary Heart Disease, Prevention, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Cancer, Good Health and Well Being, cancer, cardiovascular disease, HIV, neuropilin-1, VEGF, Clinical sciences, Medical microbiology
Abstract

Plasma vascular endothelial growth factor (VEGF) coreceptor neuropilin-1 (NRP-1) had the largest association with coronary plaque in the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) proteomics analysis. With little known about NRP-1 in people with human immunodeficiency virus (PWH), we explored its relation to other proteins in REPRIEVE and validated our findings through a Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) case-cohort study by assessing its relation to host factors and incident cardiovascular disease and cancer. Within REPRIEVE, NRP-1 was associated with proteins involved in angiogenesis, signal transduction, immunoregulation, and cell migration/adhesion. Within CNICS, NRP-1 was associated with key host factors, including older age and male sex. NRP-1 was associated with an increased hazard of multiple cancers but a decreased prostate cancer risk. Finally, NRP-1 was most strongly associated with mortality and type 2 myocardial infarction. These data suggest that NRP-1 is part of a clinically relevant immunoregulatory pathway related to multiple comorbidities in PWH. Clinical Trials Registration. NCT02344290.

Published
2023

3. Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV

Author

Kolossváry, Márton, deFilippi, Chris, McCallum, Sara, Fitch, Kathleen V, Diggs, Marissa R, Fulda, Evelynne S, Ribaudo, Heather J, Fichtenbaum, Carl J, Aberg, Judith A, Malvestutto, Carlos D, Currier, Judith S, Casado, Jose L, Gutiérrez, Félix, Sereti, Irini, Douglas, Pamela S, Zanni, Markella V, and Grinspoon, Steven K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Infectious Diseases, Prevention, HIV/AIDS, Clinical Research, Clinical Trials and Supportive Activities, Infection, Good Health and Well Being, Male, Humans, Middle Aged, Female, COVID-19, SARS-CoV-2, Pandemics, Proteomics, Blood Proteins, Antibodies, Viral, Anti-Retroviral Agents, Human immunodeficiency virus, Granzyme, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundMechanisms contributing to COVID-19 severity in people with HIV (PWH) are poorly understood. We evaluated temporal changes in plasma proteins following SARS-CoV-2 infection and identified pre-infection proteomic markers associated with future COVID-19.MethodsWe leveraged data from the global Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE). Antiretroviral therapy (ART)-treated PWH with clinical, antibody-confirmed COVID-19 as of September 2021 were matched on geographic region, age, and sample timing to antibody negative controls. For cases and controls, pre COVID-19 pandemic specimens were obtained prior to January 2020 to assess change over time and relationship to COVID-19 severity, using false-discovery adjusted mixed effects modeling.FindingsWe compared 257 unique plasma proteins in 94 COVID-19 antibody-confirmed clinical cases and 113 matched antibody-negative controls, excluding COVID-19 vaccinated participants (age 50 years, 73% male). 40% of cases were characterized as mild; 60% moderate to severe. Median time from COVID-19 infection to follow-up sampling was 4 months. Temporal patterns of protein changes differed based on COVID-19 disease severity. Among those experiencing moderate to severe disease vs. controls, NOS3 increased whereas ANG, CASP-8, CD5, GZMH, GZMB, ITGB2, and KLRD1 decreased. Higher pre-pandemic levels of granzymes A, B and H (GZMA, GZMB and GZMH) were associated with the future development of moderate-severe COVID-19 and were related to immune function.InterpretationWe identified temporal changes in proteins closely linked to inflammatory, immune, and fibrotic pathways which may relate to COVID-19-related morbidity among ART-treated PWH. Further we identified key granzyme proteins associated with future COVID-19 in PWH.FundingThis study is supported through NIH grants U01HL123336, U01HL123336-06 and 3U01HL12336-06S3, to the clinical coordinating center, and U01HL123339, to the data coordinating center as well as funding from Kowa Pharmaceuticals, Gilead Sciences, and a grant award through ViiV Healthcare. The NIAID supported this study through grants UM1 AI068636, which supports the AIDS Clinical Trials Group (ACTG) Leadership and Operations Center, and UM1 AI106701, which supports the ACTG Laboratory Center. This work was also supported by NIAID through grant K24AI157882 to MZ. The work of IS was supported by the intramural research program of NIAID/NIH.

Published
2023

5. Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy

Author

Kolossváry, Márton, deFilippi, Chris, Lu, Michael T, Zanni, Markella V, Fulda, Evelynne S, Foldyna, Borek, Ribaudo, Heather, Mayrhofer, Thomas, Collier, Ann C, Bloomfield, Gerald S, Fichtenbaum, Carl, Overton, Edgar T, Aberg, Judith A, Currier, Judith, Fitch, Kathleen V, Douglas, Pamela S, and Grinspoon, Steven K

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Cardiovascular, Heart Disease, Prevention, Atherosclerosis, Clinical Research, Heart Disease - Coronary Heart Disease, Detection, screening and diagnosis, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, Aetiology, Good Health and Well Being, Humans, Coronary Artery Disease, Cardiovascular Diseases, Proteomics, Plaque, Atherosclerotic, Risk Factors, HIV Infections, Risk Assessment, proteomics, HIV, coronary artery disease, plaque, CTA, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundPeople with HIV (PWH) have subclinical coronary artery disease (CAD) despite low traditional atherosclerotic cardiovascular disease (ASCVD) risk scores. Coronary plaque in PWH presents as a unique phenotype, but little is known about the contributions of specific inflammatory pathways to plaque phenotypes in PWH.MethodsThe REPRIEVE Mechanistic Substudy enrolled PWH on ART without known cardiovascular disease. We used a targeted discovery proteomics approach to evaluate 246 unique proteins representing cardiovascular, inflammatory, and immune pathways. Proteomic signatures were determined for presence of coronary artery calcium (CAC > 0) and presence of coronary plaque.ResultsData were available for 662 participants (aged 51 [SD 6] years, ASCVD risk score 4.9% [SD 3.1%]). Among 12 proteins associated with both CAC and presence of coronary plaque, independent of ASCVD risk score, the odds ratios were highest for NRP1: 5.1 (95% confidence interval [CI], 2.3-11.4) for CAC and 2.9 (95% CI, 1.4-6.1) for presence of plaque. Proteins uniquely related to presence of plaque were CST3, LTBR, MEPE, PLC, SERPINA5, and TNFSF13B; in contrast, DCN, IL-6RA, OSMR, ST2, and VCAM1 were only related to CAC.ConclusionsDistinct immune and inflammatory pathways are differentially associated with subclinical CAD phenotypes among PWH. This comprehensive set of targets should be further investigated to reduce atherosclerosis and ASCVD in PWH.Clinical trials registrationNCT02344290.

Published
2022

11. Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT)

Author

Williams, Michelle C., Weir-McCall, Jonathan R., Baldassarre, Lauren A., De Cecco, Carlo N., Choi, Andrew D., Dey, Damini, Dweck, Marc R., Isgum, Ivana, Kolossvary, Márton, Leipsic, Jonathon, Lin, Andrew, Lu, Michael T., Motwani, Manish, Nieman, Koen, Shaw, Leslee, van Assen, Marly, and Nicol, Edward

Published
2024
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12. Photon-counting detector CT reduces the rate of referrals to invasive coronary angiography as compared to CT with whole heart coverage energy-integrating detector

Author

Simon, Judit, Hrenkó, Áron, Kerkovits, Nóra Melinda, Nagy, Kristóf, Vértes, Miklós, Balogh, Hanna, Nagy, Norbert, Munkácsi, Tamás, Emrich, Tilman, Varga-Szemes, Akos, Boussoussou, Melinda, Vattay, Borbála, Vecsey-Nagy, Milán, Kolossváry, Márton, Szilveszter, Bálint, Merkely, Béla, and Maurovich-Horvat, Pál

Published
2024
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14. Microstructural alterations measured by diffusion tensor imaging following transcatheter aortic valve replacement and their association with cerebral ischemic injury and cognitive function — a prospective study

Author

Varga, Andrea, Gyebnár, Gyula, Suhai, Ferenc Imre, Nagy, Anikó Ilona, Kozák, Lajos Rudolf, Póka, Csenge Ágnes, Turáni, Mirjam Franciska, Borzsák, Sarolta, Apor, Astrid, Bartykowszki, Andrea, Szilveszter, Bálint, Kolossváry, Márton, Maurovich-Horvat, Pál, and Merkely, Béla

Published
2022
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16. Coronary CT-based FFR in patients with acute myocardial infarction might predict follow-up invasive FFR: The XPECT-MI study

Author

Boussoussou, Melinda, Édes, István F., Nowotta, Fanni, Vattay, Borbála, Vecsey-Nagy, Milán, Drobni, Zsófia, Simon, Judit, Kolossváry, Márton, Németh, Balázs, Jermendy, Ádám L., Becker, Dávid, Leipsic, Jonathon, Rogers, Campbell, Collinsworth, Amy, Maurovich-Horvat, Pál, Merkely, Béla, and Szilveszter, Bálint

Published
2023
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18. Radiomics in Cardiac CT

Author

Kolossváry, Márton, Maurovich-Horvat, Pál, Schoepf, U. Joseph, Series Editor, De Cecco, Carlo N., editor, van Assen, Marly, editor, and Leiner, Tim, editor

Published
2022
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31. Comparative analysis of late gadolinium enhancement assessment techniques for monitoring fibrotic changes in myocarditis follow-up

Author

Károlyi, Mihály; https://orcid.org/0000-0002-3847-3124, Polacin, Malgorzata; https://orcid.org/0000-0002-0425-5479, Kolossváry, Márton, Sokolska, Justyna M; https://orcid.org/0000-0002-4759-5879, Matziris, Ioannis, Weber, Lucas, Alkadhi, Hatem; https://orcid.org/0000-0002-2581-2166, Manka, Robert; https://orcid.org/0000-0002-3383-4998, Károlyi, Mihály; https://orcid.org/0000-0002-3847-3124, Polacin, Malgorzata; https://orcid.org/0000-0002-0425-5479, Kolossváry, Márton, Sokolska, Justyna M; https://orcid.org/0000-0002-4759-5879, Matziris, Ioannis, Weber, Lucas, Alkadhi, Hatem; https://orcid.org/0000-0002-2581-2166, and Manka, Robert; https://orcid.org/0000-0002-3383-4998

Abstract

OBJECTIVES To compare the repeatability and interrelation of various late gadolinium enhancement (LGE) assessment techniques for monitoring fibrotic changes in myocarditis follow-up. MATERIALS AND METHODS LGE extent change between baseline and 3-month cardiovascular magnetic resonance (CMR) was compared in patients with acute myocarditis using the full width at half maximum (FWHM), gray-scale thresholds at 5 and 6 standard deviations (SD5 and SD6), visual assessment with threshold (VAT) and full manual (FM) techniques. In addition, visual presence score (VPS), visual transmurality score (VTS), and a simplified visual change score (VCS) were assessed. Intraclass-correlation (ICC) was used to evaluate repeatability, and methods were compared using Spearman's correlation. RESULTS Forty-seven patients (38 male, median age: 27 [IQR: 21; 38] years) were included. LGE extent change differed among quantitative techniques (p < 0.01), with variability in the proportion of patients showing LGE change during follow-up (FWHM: 62%, SD5: 74%, SD6: 66%, VAT: 43%, FM: 60%, VPS: 53%, VTS: 77%, VCS: 89%). Repeatability was highest with FWHM (ICC: 0.97) and lowest with SD5 (ICC: 0.89). Semiquantitative scoring had slightly lower values (VPS ICC: 0.81; VTS ICC: 0.71). VCS repeatability was excellent (ICC: 0.93). VPS and VTS correlated with quantitative techniques, while VCS was positively associated with VPS, VTS, VAT, and FM, but not with FWHM, SD5, and SD6. CONCLUSION FWHM offers the least observer-dependent LGE follow-up after myocarditis. VPS, VTS, and VCS are practical alternatives, showing reliable correlations with quantitative methods. Classification of patients exhibiting either stable or changing LGE relies on the assessment technique. CLINICAL RELEVANCE STATEMENT This study shows that LGE monitoring in myocarditis is technique-dependent; the FWHM method yields the most consistent fibrotic tracking results, with scoring-based techniques as reliable alternatives. KEY POINTS Rec

Published
2024

33. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT

Author

Slart, Riemer H. J. A., Williams, Michelle C., Juarez-Orozco, Luis Eduardo, Rischpler, Christoph, Dweck, Marc R., Glaudemans, Andor W. J. M., Gimelli, Alessia, Georgoulias, Panagiotis, Gheysens, Olivier, Gaemperli, Oliver, Habib, Gilbert, Hustinx, Roland, Cosyns, Bernard, Verberne, Hein J., Hyafil, Fabien, Erba, Paola A., Lubberink, Mark, Slomka, Piotr, Išgum, Ivana, Visvikis, Dimitris, Kolossváry, Márton, and Saraste, Antti

Published
2021
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36. Photon-counting detector CT reduces the rate of referrals to invasive coronary angiography as compared to CT with whole heart coverage energy-integrating detector

Author

Simon, Judit, primary, Hrenkó, Áron, additional, Kerkovits, Nóra Melinda, additional, Nagy, Kristóf, additional, Vértes, Miklós, additional, Balogh, Hanna, additional, Nagy, Norbert, additional, Munkácsi, Tamás, additional, Emrich, Tilman, additional, Varga-Szemes, Akos, additional, Boussoussou, Melinda, additional, Vattay, Borbála, additional, Vecsey-Nagy, Milán, additional, Kolossváry, Márton, additional, Szilveszter, Bálint, additional, Merkely, Béla, additional, and Maurovich-Horvat, Pál, additional

Published
2023
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47. Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV

Author

Kolossváry, Márton, primary, deFilippi, Chris, additional, McCallum, Sara, additional, Fitch, Kathleen V., additional, Diggs, Marissa R., additional, Fulda, Evelynne S., additional, Ribaudo, Heather J., additional, Fichtenbaum, Carl J., additional, Aberg, Judith A., additional, Malvestutto, Carlos D., additional, Currier, Judith S., additional, Casado, Jose L., additional, Gutiérrez, Félix, additional, Sereti, Irini, additional, Douglas, Pamela S., additional, Zanni, Markella V., additional, and Grinspoon, Steven K., additional

Published
2023
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48. The journal of cardiovascular computed tomography: A year in review: 2022

Author

Pontone, Gianluca, primary, Mushtaq, Saima, additional, Al'Aref, Subhi J., additional, Andreini, Daniele, additional, Baggiano, Andrea, additional, Canan, Arzu, additional, Cavalcante, Joao L., additional, Chelliah, Anjali, additional, Chen, Marcus, additional, Choi, Andrew, additional, Damini, Dey, additional, De Cecco, Carlo Nicola, additional, Farooqi, Kanwal M., additional, Ferencik, Maros, additional, Feuchtner, Gudrun, additional, Hecht, Harvey, additional, Gransar, Heidi, additional, Kolossváry, Márton, additional, Leipsic, Jonathon, additional, Lu, Michael T., additional, Marwan, Mohamed, additional, Ng, Ming-Yen, additional, Maurovich-Horvat, Pál, additional, Nagpal, Prashant, additional, Nicol, Ed, additional, Weir-McCall, Jonathan, additional, Whelton, Seamus P., additional, Williams, Michelle C., additional, Reid, Anna, additional, Fairbairn, Timothy A., additional, Villines, Todd, additional, Vliegenthart, Rosemarie, additional, and Arbab-Zadeh, Armin, additional

Published
2023
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49. Biological and Clinical Implications of the Vascular Endothelial Growth Factor Coreceptor Neuropilin-1 in Human Immunodeficiency Virus.

Author

Fitch, Kathleen, Fitch, Kathleen, Ambayec, Gabrielle, Nance, Robin, Zanni, Markella, Diggs, Marissa, Chan, Fay, McCallum, Sara, Toribio, Mabel, Bamford, Laura, Fichtenbaum, Carl, Eron, Joseph, Jacobson, Jeffrey, Mayer, Kenneth, Malvestutto, Carlos, Bloomfield, Gerald, Moore, Richard, Umbleja, Triin, Saag, Michael, Aberg, Judith, Currier, Judith, Delaney, Joseph, Martin, Jeffrey, Lu, Michael, Douglas, Pamela, Ribaudo, Heather, Crane, Heidi, Hunt, Peter, Grinspoon, Steven, Schnittman, Samuel, Kolossváry, Márton, Beck-Engeser, Gabriele, Fitch, Kathleen, Fitch, Kathleen, Ambayec, Gabrielle, Nance, Robin, Zanni, Markella, Diggs, Marissa, Chan, Fay, McCallum, Sara, Toribio, Mabel, Bamford, Laura, Fichtenbaum, Carl, Eron, Joseph, Jacobson, Jeffrey, Mayer, Kenneth, Malvestutto, Carlos, Bloomfield, Gerald, Moore, Richard, Umbleja, Triin, Saag, Michael, Aberg, Judith, Currier, Judith, Delaney, Joseph, Martin, Jeffrey, Lu, Michael, Douglas, Pamela, Ribaudo, Heather, Crane, Heidi, Hunt, Peter, Grinspoon, Steven, Schnittman, Samuel, Kolossváry, Márton, and Beck-Engeser, Gabriele

Abstract

Plasma vascular endothelial growth factor (VEGF) coreceptor neuropilin-1 (NRP-1) had the largest association with coronary plaque in the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) proteomics analysis. With little known about NRP-1 in people with human immunodeficiency virus (PWH), we explored its relation to other proteins in REPRIEVE and validated our findings through a Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) case-cohort study by assessing its relation to host factors and incident cardiovascular disease and cancer. Within REPRIEVE, NRP-1 was associated with proteins involved in angiogenesis, signal transduction, immunoregulation, and cell migration/adhesion. Within CNICS, NRP-1 was associated with key host factors, including older age and male sex. NRP-1 was associated with an increased hazard of multiple cancers but a decreased prostate cancer risk. Finally, NRP-1 was most strongly associated with mortality and type 2 myocardial infarction. These data suggest that NRP-1 is part of a clinically relevant immunoregulatory pathway related to multiple comorbidities in PWH. Clinical Trials Registration. NCT02344290.

Published
2023

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