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11 results on '"Kolker, Daniel E."'

2. Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters

Author

Kolker, Daniel E., Olson, Susan Losee, Dutton-Boilek, Jeanette, Bennett, Katherine M., Wallen, Edward P., Horton, Teresa H., and Turek, Fred W.

Subjects
Melatonin -- Physiological aspects, Triazolam -- Research, Aging -- Physiological aspects, Circadian rhythms -- Research, Biological sciences
Abstract

Aging alters many aspects of circadian rhythmicity, including responsivity to phase-shifting stimuli and the amplitude of the rhythm of melatonin secretion. As melatonin is both an output from and an input to the circadian clock, we hypothesized that the decreased melatonin levels exhibited by old hamsters may adversely impact the circadian system as a whole. We enhanced the diurnal rhythm of melatonin by feeding melatonin to young and old hamsters. Animals of both age groups on the melatonin diet showed larger phase shifts than control-fed animals in response to an injection with the benzodiazepine triazolam at a circadian time known to induce phase advances in the activity rhythm of young animals. Thus melatonin treatment can increase the sensitivity of the circadian timing system of young animals to a nonphotic stimulus, and the ability to increase this sensitivity persists into old age, indicating exogenous melatonin might be useful in reversing at least some age-related changes in circadian clock function. aging; circadian

Published
2002

3. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease

Author

Penev, Plamen D., Kolker, Daniel E., Zee, Phyllis C., and Turek, Fred W.

Subjects
Hamsters -- Physiological aspects, Heart diseases -- Physiological aspects, Circadian rhythms -- Physiological aspects, Biological sciences
Abstract

A study was conducted to analyze the influence of induced circadian desynchronization and resynchronization in the light-dark cycle on the longevity of hamsters supporting progressive heart disease. Experimental results showed that repeated circadian desynchronization supported harmful effects on the survival of hamsters. In addition, the temporal synchronization had a significant impact on the course and result of chronic cardiovascular disease.

Published
1998

5. Contributors

Author

Abel, Ty W., primary, Aisen, Paul S., additional, Alexander, Gene E., additional, Allman, John M., additional, Anderson, Nicole D., additional, Armstrong, David M., additional, Avis, Nancy E., additional, Baxter, Mark G., additional, Beal, M. Flint, additional, Bouras, Constantin, additional, Browne, Susan E., additional, Buée, Luc, additional, Burkard, Robert, additional, Bussière, Thierry, additional, Cassel, Christine K., additional, Conley, Kevin E., additional, Copinschi, Georges, additional, Cotman, Carl W., additional, Cowen, Tim, additional, Cronin-Golomb, Alice, additional, De Kloet, E. Ron, additional, Delacourte, André, additional, Dhenain, Marc, additional, Dickson, Dennis W., additional, Ding, Dalian, additional, Doty, Richard L., additional, Duan, Huiling, additional, Eddins, Ann Clock, additional, Ek, Kirsten, additional, Erwin, Joseph M., additional, Eshuis, S.A., additional, Frisina, D. Robert, additional, Frisina, Robert D., additional, Furey, Maura L., additional, Gabaldón, A.M., additional, Gannon, Patrick J., additional, Gerhardt, Greg A., additional, Giannakopoulos, Panteleimon, additional, Gilissen, Emmanuel P., additional, Godschalk, Michael, additional, Gold, Gabriel, additional, Grady, Cheryl L., additional, Gruenewald, David A., additional, Guazzelli, Mario, additional, Hansen, Lawrence, additional, Harvey, Philip D., additional, Hays, Nicholas P., additional, Head, Elizabeth, additional, Hebert, Meleik A., additional, Henderson, Donald, additional, Hernandez, M. Rosario, additional, Herrmann, François R., additional, Hof, Patrick R., additional, Horwitz, B.A., additional, Ikonomovic, Milos, additional, Ingram, Donald K., additional, Ison, James R., additional, Joray, Sabine, additional, Joyce, Jeffrey N., additional, Jubrias, Sharon A., additional, Keck, B. Jane, additional, Kolker, Daniel E., additional, Kordower, Jeffrey H., additional, Kövari, Enikö, additional, Kuchel, George A., additional, Kuljis, Rodrigo O., additional, Kuno, Helen, additional, Lakoski, Joan M., additional, LaPolt, Philip S., additional, Leenders, K.L., additional, Leproult, Rachel, additional, Lu, John K.H., additional, Lucassen, Paul J., additional, Magistretti, Pierre J., additional, Marin, Deborah B., additional, Masliah, Eliezer, additional, Matsumoto, Alvin M., additional, Mattson, Mark P., additional, McCoy, Norma L., additional, McDonald, R.B., additional, McFadden, Sandra L., additional, McKeon-O'Malley, Catherine, additional, Michel, Jean-Pierre, additional, Milgram, Norton William, additional, Mishizen, Amanda, additional, Mobbs, Charles V., additional, Mohs, Richard C., additional, Mufson, Elliott J., additional, Mulligan, Thomas, additional, Neufeld, Arthur H., additional, Nimchinsky, Esther A., additional, Pasinetti, Giulio Maria, additional, Pellerin, Luc, additional, Perl, Daniel P., additional, Pietrini, Pietro, additional, Rance, Naomi E., additional, Riggs, Jack E., additional, Roberts, Susan B., additional, Rowe, John W., additional, Salvi, Richard J., additional, Sims, Donald G., additional, Smith, Matthew J., additional, Snell, Karen B., additional, Sonntag, William E., additional, Stanford, John A., additional, Tanzi, Rudolph, additional, Thornton, Phillip L., additional, Tsopelas, Nicholas D., additional, Turek, Fred W., additional, Vallet, Philippe G., additional, Van Cauter, Eve, additional, Vickers, James C., additional, Vogt, Brent A., additional, Vogt, Leslie J., additional, Walton, Joseph P., additional, Willott, James F., additional, and Wise, Phyllis M., additional

Published
2001
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9. Automated Measurement of Mouse Freezing Behavior and its Use for Quantitative Trait Locus Analysis of Contextual Fear Conditioning in (BALB/cJ × C57BL/6J)F2Mice

Author

Valentinuzzi, Verónica S., primary, Kolker, Daniel E., additional, Vitaterna, Martha Hotz, additional, Shimomura, Kazuhiro, additional, Whiteley, Andrew, additional, Low-Zeddies, Sharon, additional, Turek, Fred W., additional, Ferrari, Elenice A.M., additional, Paylor, Richard, additional, and Takahashi, Joseph S., additional

Published
1998
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10. Staffing for science

Author

Kolker, Daniel E.

Subjects
Research -- Employment -- Statistics, Biological sciences, Statistics, Employment
Abstract

The generous funding of US academic labs has helped dramatically advance our understanding of diseases and their underlying biology. But is the structure of the academic lab well-suited to optimize [...]

Published
2004

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