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21 results on '"Kolben, Theresa Maria"'

4. POSTER 19Regulation of epigenetic modifications in the placenta during preeclampsia: PPARγ influences H3K4me3 and H3K9ac in extravillous trophoblast cells

Author

Meister, Sarah, primary, Hahn, Laura, additional, Beyer, Susanne, additional, Paul, Corinna, additional, Mitter, Sophie, additional, Kuhn, Christina, additional, von Schönfeldt, Viktoria, additional, Corradini, Stefanie, additional, Sudan, Kritika, additional, Schulz, Christian, additional, Kolben, Theresa Maria, additional, Mahner, Sven, additional, Jeschke, Udo, additional, and Kolben, Thomas, additional

Published
2023
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9. Epigenetic changes occur in placentas of spontaneous and recurrent miscarriages

Author

Meister, Sarah, primary, Kellner, Isabel, additional, Beyer, Susanne, additional, Corradini, Stefanie, additional, Schulz, Christian, additional, Rogenhofer, Nina, additional, Keilmann, Lucia, additional, Kolben, Theresa Maria, additional, Mahner, Sven, additional, Kessler, Mirjana, additional, Jeschke, Udo, additional, and Kolben, Thomas, additional

Published
2022
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10. Regulation of Epigenetic Modifications in the Placenta during Preeclampsia: PPARγ Influences H3K4me3 and H3K9ac in Extravillous Trophoblast Cells

Author

Meister, Sarah, primary, Hahn, Laura, additional, Beyer, Susanne, additional, Paul, Corinna, additional, Mitter, Sophie, additional, Kuhn, Christina, additional, von Schönfeldt, Viktoria, additional, Corradini, Stefanie, additional, Sudan, Kritika, additional, Schulz, Christian, additional, Kolben, Theresa Maria, additional, Mahner, Sven, additional, Jeschke, Udo, additional, and Kolben, Thomas, additional

Published
2021
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11. The role of E-Cadherin expression in primary site of breast cancer

Author

Karsten, Nora, primary, Kolben, Thomas, additional, Mahner, Sven, additional, Beyer, Susanne, additional, Meister, Sarah, additional, Kuhn, Christina, additional, Schmoeckel, Elisa, additional, Wuerstlein, Rachel, additional, Harbeck, Nadia, additional, Ditsch, Nina, additional, Jeschke, Udo, additional, Friese, Klaus, additional, and Kolben, Theresa Maria, additional

Published
2021
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12. Epigenetic modification via H3K4me3 and H3K9ac in human placenta is reduced in preeclampsia

Author

Meister, Sarah, primary, Hahn, Laura, additional, Beyer, Susanne, additional, Kuhn, Christina, additional, Jegen, Magdalena, additional, von Schönfeldt, Viktoria, additional, Corradini, Stefanie, additional, Schulz, Christian, additional, Kolben, Theresa Maria, additional, Hester, Anna, additional, Appelt, Tamara, additional, Mahner, Sven, additional, Jeschke, Udo, additional, and Kolben, Thomas, additional

Published
2021
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14. Involvement of ILR4α and TLR4 in miscarriages

Author

Kolben, Theresa Maria, primary, Rogatsch, Elisabeth, additional, Hester, Anna, additional, Kuhn, Christina, additional, Schmoeckel, Elisa, additional, Czogalla, Bastian, additional, Mahner, Sven, additional, Jeschke, Udo, additional, and Kolben, Thomas, additional

Published
2019
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15. A randomized trial comparing limited-excision conisation to Large Loop Excision of the Transformation Zone (LLETZ) in cervical dysplasia patients

Author

Kolben, Theresa Maria, primary, Etzel, Lea T, additional, Bergauer, Florian, additional, Hagemann, Ingke, additional, Hillemanns, Peter, additional, Repper, Monika, additional, Kaufmann, Andreas M, additional, Sotlar, Karl, additional, Kolben, Thomas, additional, Helms, Hans-Joachim, additional, Gallwas, Julia, additional, Mahner, Sven, additional, and Dannecker, Christian, additional

Published
2019
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16. The role of EP3-receptor expression in cervical dysplasia

Author

Hester, Anna, primary, Ritzer, Manuel, additional, Kuhn, Christina, additional, Schmoeckel, Elisa, additional, Mayr, Doris, additional, Kolben, Thomas, additional, Dannecker, Christian, additional, Mahner, Sven, additional, Jeschke, Udo, additional, and Kolben, Theresa Maria, additional

Published
2018
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17. Delayed interval delivery in multiple gestations: the Munich experience

Author

Kolben, Thomas, primary, Fischer, Daniel, additional, Ruehl, Ina, additional, Franz, Marie, additional, Hester, Anna, additional, Kolben, Theresa Maria, additional, Deppe, Charlotte, additional, Delius, Maria, additional, Friese, Klaus, additional, Mahner, Sven, additional, Hasbargen, Uwe, additional, and Hübener, Christoph, additional

Published
2018
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20. A randomized trial comparing limitedexcision conisation to Large Loop Excision of the Transformation Zone (LLETZ) in cervical dysplasia patients.

Author

Kolben, Theresa Maria, Etzel, Lea T., Bergauer, Florian, Hagemann, Ingke, Hillemanns, Peter, Repper, Monika, Kaufmann, Andreas M., Sotlar, Karl, Kolben, Thomas, Helms, Hans-Joachim, Gallwas, Julia, Mahner, Sven, and Dannecker, Christian

Subjects
*CONIZATION, *CERVICAL intraepithelial neoplasia, *SURGICAL excision
Abstract

Objective: To show noninferiority of a limited-excision (resection of the dysplastic lesion only) vs. classical Large Loop Excision of the Transformation Zone (LLETZ). Methods: In this prospective, randomized, multicenter trial, women with human papillomavirus (HPV) positive cervical intraepithelial neoplasia grade 3 were randomized into two groups (1:1). Primary outcome was the rate of negative HPV tests after 6 months, secondary outcomes included cone size, complete resection rates as well as cytological and histological results after 6 and 12 months. A sample size of 1,000 was calculated to show noninferiority of the limited-excision compared to the LLETZ group using a noninferiority margin of 5%. Enrollment was stopped after 100 patients due to slow accrual. Results: Patients in the limited-excision group did not show a lower number of negative HPV tests (78% [LLETZ]-80% [limited-excision]=-2%; 90% confidence interval=-15%, 12%). The limited-excision resulted in a substantially lower cone size (LLETZ: 1.97 mL vs. limitedexcision: 1.02 mL; p<0.001) but higher numbers of involved margins (LLETZ: 8% vs. limitedexcision: 20%). Although postoperative cytological results slightly differed, histological results were similar in both groups. One limited-excision patient received immediate re-conisation, whereas one patient in each group was scheduled for re-conisation after 6 months. Conclusion: The limited-excision could represent a promising option to reduce the surgical extent of conisations while maintaining oncological safety. The trial was not sufficiently powered to reach statistical significance due to early termination. Nevertheless, the study provides important insights in the feasibility of a limited-excision and could serve as a pilot study for future trials. [ABSTRACT FROM AUTHOR]

Published
2019
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21. PPARγ Expression Is Diminished in Macrophages of Recurrent Miscarriage Placentas.

Author

Kolben TM, Rogatsch E, Vattai A, Hester A, Kuhn C, Schmoeckel E, Mahner S, Jeschke U, and Kolben T

Subjects
Adolescent, Adult, Antigens, CD metabolism, Antigens, Differentiation, Myelomonocytic metabolism, CX3C Chemokine Receptor 1 metabolism, Chemokine CCL1 metabolism, Decidua metabolism, Decidua pathology, Demography, Female, Humans, Nitric Oxide Synthase Type II metabolism, PPAR gamma metabolism, Pregnancy, RNA, Messenger genetics, RNA, Messenger metabolism, Toll-Like Receptor 2 metabolism, Trophoblasts metabolism, Trophoblasts pathology, Young Adult, Abortion, Habitual genetics, Abortion, Habitual pathology, Macrophages metabolism, PPAR gamma genetics, Placenta metabolism, Placenta pathology
Abstract

PPARγ belongs to the group of nuclear receptors which is expressed in the trophoblast and together with other factors is responsible for the maintenance of pregnancy. Apart from that PPARγ is also a main factor for macrophage polarization. The aim of this study was to investigate the combined expression pattern and frequency of PPARγ under physiological circumstances and in spontaneous and recurrent miscarriages in the trophoblast and in maternal macrophages of the decidua. Human placental tissues of the first trimester (15 physiologic pregnancies, 15 spontaneous abortion and 16 recurrent miscarriage placentas) were analyzed for expression of the nuclear receptor PPARγ. Expression changes were evaluated by immunohistochemistry and real time PCR (RT-PCR) in trophoblast and in maternal macrophages of the decidua. Maternal macrophages were identified by double immunofluorescence using cluster of differentiation 68 (CD68) as marker for macrophages and further characterized regarding their M1/M2 polarization status. The intermediate villous trophoblast revealed a significantly lower PPARγ expression in spontaneous and recurrent abortion. Maternal macrophages express PPARγ. Their number is significantly enhanced in the decidua of spontaneous miscarriages whereas in recurrent miscarriages maternal macrophages seem to express PPARγ only in very few cases. PPARγ is associated with an M2 polarization state that is common for decidual macrophages. The lack of PPARγ in recurrent miscarriage decidual macrophages seems to be associated with a specific inflammatory response against the fetus.

Published
2018
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