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This guideline applies to non-pregnant patients of ages >18 years with suspected or diagnosed venous thromboembolism (VTE), especially those with severe disease, or those with less common clinical scenarios. This document focuses primarily but not exclusively on inpatient, observation, and emergency department services for patients with suspected or diagnosed VTE. The objective of this guideline is to provide evidence-based recommendations to address special clinical scenarios related to VTE. This guideline covers VTE-related scenarios such as the extremes of severity (eg. incidentally discovered asymptomatic pulmonary embolism (PE); massive PE; obstructive, proximal deep venous thromboembolism (DVT), or scenarios that are less common and, therefore, more likely to involve difficult or nuanced decision-making (eg. calf vein, portal vein, or mesenteric vein thrombosis). The document also addresses upper extremity and catheter-associated VTE, and criteria for admitting and discharging patients with PE., (© Regents of the University of Michigan.)