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27 results on '"Kolb KH"'

1. Intravenöse Cholegraphie mit Chologram®*

Author

Heitzeberg H, Blumenbach L, Wolf R, Taenzer, Kolb Kh, and Ulrich Speck

Subjects
Double blind, Bilivistan, business.industry, Computer science, Radiology, Nuclear Medicine and imaging, Artificial intelligence, business, computer.software_genre, computer, Natural language processing, Trade name
Abstract

A double blind comparison between Ioglycamid (Bilivistan) and the new I-V cholegraphic medium Iotroxamid (proposed trade name Chologram) is reported. Chologram produces better pictures and it is better tolerated. Pharmaco-kinetic data are published for the first time.

Published
1975
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2. ABSORPTION, DISTRIBUTION AND ELIMINATION OF LABELED DIMETHYL SULFOXIDE IN MAN AND ANIMALS

Author

Kolb Kh, Schulze Pe, G. Jaenicke, and Kramer M

Subjects
Chemistry, Dimethyl sulfoxide, Skin Absorption, General Neuroscience, Radiochemistry, Absorption (skin), Isotopes of sulfur, Tritium, General Biochemistry, Genetics and Molecular Biology, Rats, Aqueous Humor, chemistry.chemical_compound, Dogs, History and Philosophy of Science, Injections, Intravenous, Sulfur Isotopes, Animals, Autoradiography, Humans, Distribution (pharmacology), Organic chemistry, Dimethyl Sulfoxide, Rabbits
Published
1967
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4. Victim advocates' perceptions of legal work.

Author

Kolb KH

Subjects
Communication, Confidentiality, Credentialing, Crime Victims, Female, Humans, Male, Prejudice, Professional Role, Public Opinion, Social Support, Women's Health Services, Criminal Law, Empathy, Patient Advocacy legislation & jurisprudence, Perception, Rape legislation & jurisprudence, Social Values, Spouse Abuse legislation & jurisprudence
Abstract

Past scholarship has weighed the risks and rewards of legal remedies for victims of domestic violence and sexual assault. Missing from this debate, however, is an analysis of the social incentives for victim advocates to offer legal options to their clients. Preliminary findings show that victim advocates perceive that outsiders respect legal work more than their care work with clients (listening, caring, and empathizing). This study offers three explanations for this phenomenon: (1) the devaluation of women's care work in general, (2) the confidentiality constraints on communicating the value of their care work, and (3) popular assumptions that care work requires professional credentials in order to be legitimate.

Published
2011
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5. [Measuring the potential difference of gastric mucosa as a means of quantifying the protective effect of Al-acetylglycyrrhetinate after a dose of acetylsalicylic acid (author's transl)].

Author

Altmayer P, Lücker PW, and Kolb KH

Subjects
Adult, Dose-Response Relationship, Drug, Female, Glycyrrhetinic Acid pharmacology, Humans, Male, Membrane Potentials drug effects, Premedication, Aspirin toxicity, Gastric Mucosa drug effects, Glycyrrhetinic Acid analogs & derivatives
Abstract

A clinical pharmacological model to measure the potential difference of the gastric mucosa is reported. The model partially from literature derived has been further developed mathematically. An irritation index is reliable to quantify the protective function of chemical agents. In the reported study Al-acetylsalicylic acid (ASA): The measured parameters (Pdmax, AUB) show that the irritation of the gastric mucosa induced by ASA can be reduced if 100 mg Al-acetylglycyrrhetinate has been predosed. After the instillation of 1000 mg ASA the mean Pdmax amounts to 27.20 [mV] (s = 9.63), the AUB to 930.60 [mV . mins] (s = 311.10). After pre-treatment with Al-acetylglycyrrhetinate the irritation of ASA only produces a Pdmax of 17.80 [mV] (s = 986) and and AUB of 678.60 [mV . min] (s = 374.11). The differences of Pdmax and AUB are significant on the 5% level. The irritation index for 1000 mg ASA amounts to 27.5 [mV2 . min], after pre-treatment with 100 mg Al-acetylglycyrrhetinate it decrease to 14.9 [mV2 . min].

Published
1981

6. [Intravenous cholegraphy with Chologram (a double blind comparison with Bilivistan) (author's transl)].

Author

Taenzer V, Blumenbach L, Heitzeberg H, Kolb KH, Speck U, and Wolf R

Subjects
Chemical Phenomena, Chemistry, Cholangiography, Cholecystography, Humans, Biliary Tract diagnostic imaging, Iodobenzoates, Ioglycamic Acid adverse effects, Triiodobenzoic Acids adverse effects, Triiodobenzoic Acids analogs & derivatives, Triiodobenzoic Acids metabolism
Abstract

A double blind comparison between Ioglycamid (Bilivistan) and the new I-V cholegraphic medium Iotroxamid (proposed trade name Chologram) is reported. Chologram produces better pictures and it is better tolerated. Pharmaco-kinetic data are published for the first time.

Published
1975
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7. [Pharmacokinetics and metabolite spectrum of glisoxepide in humans].

Author

Speck U, Mützel W, Kolb KH, Acksteiner B, and Schulze PE

Subjects
Adult, Aged, Carbon Dioxide metabolism, Carbon Radioisotopes, Chromatography, Diabetes Mellitus metabolism, Drug Evaluation, Feces analysis, Female, Half-Life, Humans, Kidney metabolism, Kinetics, Male, Middle Aged, Spectrophotometry, Ultraviolet, Sulfur Radioisotopes, Tritium, Azepines metabolism, Hypoglycemic Agents metabolism, Oxazoles metabolism, Sulfonylurea Compounds metabolism
Published
1974

8. [Pharmacokinetics of radioactively labeled glisoxepide in the animal].

Author

Kolb KH, Schulze PE, Speck U, and Acksteiner B

Subjects
Animals, Bile metabolism, Carbon Radioisotopes, Computers, Dogs, Drug Evaluation, Preclinical, Feces analysis, Female, Half-Life, Haplorhini, Kidney metabolism, Kinetics, Male, Pancreas metabolism, Papio, Rabbits, Rats, Species Specificity, Sulfur Radioisotopes, Time Factors, Tritium, Azepines metabolism, Hypoglycemic Agents metabolism, Oxazoles metabolism, Sulfonylurea Compounds metabolism
Published
1974

9. [Human-pharmacokinetic Studies on Penetration Kinetics of a 6 alpha-Fluoro-9 alpha-chloro-16 alpha-methyl-delta 1,4-pregnadiene-11 beta-dihydroxy-3,20-dione-21-trimethyl-acetic acid (Clocortolone Trimethyl-acetic acid) after e picutaneous application].

Author

Kolb KH, Latza R, Hepp-Latza O, Lücker PW, Rindt W, and Simon B

Subjects
Administration, Topical, Female, Fluocortolone administration & dosage, Fluocortolone analogs & derivatives, Humans, Kinetics, Skin Absorption, Time Factors, Fluocortolone metabolism, Pregnadienediols metabolism
Abstract

Investigation on 6 alpha-fluoro-9 alpha-chloro-16 alpha-methyl-delta 1,4-pregnadiene-11 beta-dihydroxy-3,20-dione-21-trimethylacetic acid (clocortolone trimethylacetic acid) are reported. The aim of the trial was to prove the penetration kinetics of the steriod into the skin. Three healthy female subjects took part in the investigations. They were treated with an oil-water emulsion of the substance on two spots on the back, after having observed alcohol abstinence. One of the treated spots was stripped after 30 min, the second after 60 min using the "Tesafilm" stripping method. The strips were then analysed gaschromatographically on the presence of clocortolone-trimethylacetic acid. It could be shown that the steroid penetrates into the skin up to the 12th-14th strips, building up a certain congestion of the substance at this time because of reaching the stratum corneum, as we suppose. At this place a depot is built of which probably only a very small or no permeation into the system occurs, as clocortolone could not be detected either in the subjects' serum nor in the urine.

Published
1978

13. [RESORPTION, DISTRIBUTION AND EXCRETION OF RADIOACTIVE-LABELLED 2-BENZENESULFONAMIDO-5-(2-METHOXYETHOXY)-PYRIMIDINE (GLYCODIAZIN) IN ANIMAL EXPERIMENTS].

Author

KOLB KH, KRAMER M, and SCHULZE PE

Subjects
Animals, Dogs, Rabbits, Rats, Sulfanilamide, Sulfanilamides, Animal Experimentation, Blood Chemical Analysis, Fluids and Secretions, Hypoglycemic Agents, Intestinal Absorption, Metabolism, Pyrimidines, Radioisotopes, Radionuclide Imaging, Research, Sulfonamides, Sulfur Isotopes, Urine
Published
1964

16. [On benzenesulfonylamino-5-[beta-methoxyethoxy]-pyrimidine (glycodiazine). 3. Glycodiazine plasma concentration and blood sugar lowering effects in humans, as well as the influence of glycodiazine on the hypophyseal-adrenal cortex system].

Author

Gerhards E, Gibian H, and Kolb KH

Subjects
Adrenal Glands physiology, Adrenocorticotropic Hormone, Animals, Blood, Humans, Hypoglycemia, In Vitro Techniques, Rats, Adrenal Cortex Hormones, Adrenal Glands drug effects, Blood Glucose, Hypoglycemic Agents pharmacology, Pituitary Gland drug effects
Published
1965

18. [Studies on the intestinal absorption of sympathomimetics in man].

Author

Petry R and Kolb KH

Subjects
Amines metabolism, Carbon Radioisotopes, Humans, Norepinephrine metabolism, Sulfonic Acids metabolism, Time Factors, Ethanolamines metabolism, Intestinal Absorption, Phenethylamines metabolism, Sympathomimetics metabolism
Published
1973

19. [Distribution of 1-butyl-biguanide- 14 C in rats and guinea pigs].

Author

Losert W, Kolb KH, and Bitterling G

Subjects
Administration, Oral, Animals, Biguanides administration & dosage, Biguanides blood, Biguanides urine, Blood Glucose metabolism, Carbon Isotopes, Feces analysis, Guinea Pigs, Injections, Subcutaneous, Liver metabolism, Male, Muscles metabolism, Protein Binding, Rats, Rats, Inbred Strains, Biguanides metabolism
Published
1972

20. [Simulation of the biodynamics of glycodiazine with the analog computer].

Author

Riemann J, Röpke H, Gerhards E, Kolb KH, and Gibian H

Subjects
Acids metabolism, Alcohols blood, Alcohols metabolism, Alcohols urine, Digestive System metabolism, Hypoglycemic Agents blood, Hypoglycemic Agents urine, Kinetics, Computers, Analog, Hypoglycemic Agents metabolism, Models, Biological, Sulfonamides metabolism
Published
1968

23. [Pharmacokinetics of cyproterone acetate. A comparative study in humans and baboons].

Author

Kolb KH and Roepke H

Subjects
Adipose Tissue metabolism, Adrenal Glands metabolism, Animals, Biotransformation, Brain metabolism, Carbon Isotopes, Computers, Analog, Digestive System metabolism, Eye metabolism, Gallbladder metabolism, Haplorhini, Humans, Kidney metabolism, Kinetics, Liver metabolism, Lung metabolism, Lymph Nodes metabolism, Mesentery metabolism, Models, Biological, Muscles metabolism, Myocardium metabolism, Pancreas metabolism, Skin metabolism, Species Specificity, Spleen metabolism, Thymus Gland metabolism, Thyroid Gland metabolism, Tritium, Urinary Bladder metabolism, Androgen Antagonists, Pregnanes metabolism
Published
1968

25. [On metabolism of 17-beta-acetoxy-1-methyl-delta-1-5-alpha-androstenone-(3) (methenolone acetate) in man. II. Isolation and identification of 3-alpha-hydroxy-1-methylene-5-alpha-androstanone-(17) and other metabolites and on mechanism of ring-A-reduction].

Author

Gerhards E, Kolb KH, and Schulze PE

Subjects
Adult, Androgens analysis, Carbon Isotopes, Chromatography, Electrophoresis, Feces analysis, Glucuronates analysis, Humans, Male, Methenolone blood, Methenolone urine, Tritium, Androgens metabolism, Methenolone administration & dosage, Methenolone metabolism
Published
1965

26. Recent aspects of pharmacokinetics.

Author

Kolb KH

Subjects
Animals, Humans, Methods, Models, Biological, Radioisotopes, Pharmaceutical Preparations metabolism
Published
1968

27. [On 2-benzolsulfonylamino-5(beta-methoxy-ethoxy)-pyrimidine (glycodiazine. V. In vitro and in vivo experiments on the action of phenylethylbarbituric acid (Luminal) on the metabolism and blood sugar reducing effect of glycodiazine].

Author

Gerhards E, Kolb KH, and Schulze PE

Subjects
Adult, Animals, Blood Glucose analysis, Dogs, Humans, In Vitro Techniques, Liver enzymology, Male, Perfusion, Pyrimidines metabolism, Rats, Reticulum metabolism, Tritium, Liver metabolism, Phenobarbital pharmacology, Pyrimidines pharmacology, Tolbutamide metabolism
Published
1966

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