Search

Your search keyword '"Kolb, Hartmuth"' showing total 597 results
Start Over Author "Kolb, Hartmuth"
597 results on '"Kolb, Hartmuth"'

1. Clinical Meaningfulness in Alzheimer’s Disease Clinical Trials. A Report from the EU-US CTAD Task Force

Author

Angioni, D., Cummings, J., Lansdall, C. J., Middleton, L., Sampaio, C., Gauthier, S., Cohen, S., Petersen, R. C., Rentz, D. M., Wessels, A. M., Hendrix, S. B., Jessen, F., Carrillo, M. C., Doody, R. S., Irizarry, M., Andrews, J. S., Vellas, B., Aisen, P., Andrieu, Sandrine, Bateman, Randall, Batrla, Richard, Bell, Joanne, Bosson, Oskar, Bozeat, Sasha, Brooks, Dawn, Haeberlein, Samantha Budd, Buracchio, Teresa, Cho, Min, Choung, Matthew, Cook, Gavin, Crisitello, Darrin, Dangond, Fernando, de Santi, Susan, Dennehy, Ellen, Dhadda, Shobha, Dhillon, Harjeet, Dunn, Billy, Egan, Michael, Elwood, Fiona, Eriksson, Sven, Fagan, Tom, Fillit, Howard, Freskgard, Per-Ola, Gallagher, Diana, Gangi, Gopi, Granda, Carlos, Greeley, David, Gronblad, Anna-Kaija, Hampel, Harald, Hawthorne, Paul, Henley, David, Herring, Joe, Hersch, Steve, Holt, Bill, Iwatsubo, Takeshi, Jones, Daryl, Kahl, Anja, Kinney, Gene, Kolb, Hartmuth, Kramer, Lynn, Kulic, Luka, Kumar, Sanjay, Lannfelt, Lars, Lawson, John, Legrand, Valérie, Lenington, Rachel, Longo, Frank, Matthews, Brandy, Masterman, Donna, McLinden, Kristina, Mikels, Sarah, Miller, Michael, Mintun, Mark, Moebius, Hans, Monteiro, Cecilia, Morken, Mario, Murphy, Jennifer, Odergren, Tomas, Osswald, Gunilla, Parnas, Laura, Patru, Maria-Magdalena, Prazma, Charlene, Raman, Rema, Reyderman, Larisa, Rogers, Sharon, Roman, Lise, Romano, Gary, Roskey, Mark, Rubino, Ivana, Ryan, Laurie, Salloway, Stephen, Schindler, Rachel, Schneider, Lon, Scott, David, Sims, John, Skovronsky, Daniel, Soto, Marion, Sperling, Reisa, Steukers, Lennert, Stoops, Erik, Strittmatter, Stephen, Tahami, Amir, Tamagnan, Gilles, Tariot, Gilles, Toloue, Masoud, Touchon, Jacques, Vanmechelen, Eugeen, Walt, Len, Weinberg, Mark, Weiner, Michael, White, Anne, Wiesel, Iris, Wilson, David, Yarenis, Lisa, Zago, Wagner, and Zhou, Jin

Published
2024
Full Text
View/download PDF

2. Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Author

Sanchez-Rodriguez, Lazaro M, Bezgin, Gleb, Carbonell, Felix, Therriault, Joseph, Fernandez-Arias, Jaime, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Karikari, Thomas K, Ashton, Nicholas J, Benedet, Andréa L, Zetterberg, Henrik, Blennow, Kaj, Triana-Baltzer, Gallen, Kolb, Hartmuth C, Rosa-Neto, Pedro, and Iturria-Medina, Yasser

Subjects
Biochemistry and Cell Biology, Biological Sciences, Clinical Research, Acquired Cognitive Impairment, Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Neurosciences, Biomedical Imaging, Alzheimer's Disease, Neurodegenerative, Dementia, Aetiology, 2.1 Biological and endogenous factors, Neurological, Alzheimer Disease, Humans, tau Proteins, Amyloid beta-Peptides, Brain, Male, Female, Aged, Magnetic Resonance Imaging, Middle Aged, Positron-Emission Tomography, Models, Neurological, Biomarkers, Aged, 80 and over, Electroencephalography, Neurons, Biological sciences, Biomedical and clinical sciences
Abstract

Neuronal dysfunction and cognitive deterioration in Alzheimer's disease (AD) are likely caused by multiple pathophysiological factors. However, mechanistic evidence in humans remains scarce, requiring improved non-invasive techniques and integrative models. We introduce personalized AD computational models built on whole-brain Wilson-Cowan oscillators and incorporating resting-state functional MRI, amyloid-β (Aβ) and tau-PET from 132 individuals in the AD spectrum to evaluate the direct impact of toxic protein deposition on neuronal activity. This subject-specific approach uncovers key patho-mechanistic interactions, including synergistic Aβ and tau effects on cognitive impairment and neuronal excitability increases with disease progression. The data-derived neuronal excitability values strongly predict clinically relevant AD plasma biomarker concentrations (p-tau217, p-tau231, p-tau181, GFAP) and grey matter atrophy obtained through voxel-based morphometry. Furthermore, reconstructed EEG proxy quantities show the hallmark AD electrophysiological alterations (theta band activity enhancement and alpha reductions) which occur with Aβ-positivity and after limbic tau involvement. Microglial activation influences on neuronal activity are less definitive, potentially due to neuroimaging limitations in mapping neuroprotective vs detrimental activation phenotypes. Mechanistic brain activity models can further clarify intricate neurodegenerative processes and accelerate preventive/treatment interventions.

Published
2024

3. Novel avenues of tau research

Author

Sexton, Claire E, Bitan, Gal, Bowles, Kathryn R, Brys, Miroslaw, Buée, Luc, Maina, Mahmoud Bukar, Clelland, Claire D, Cohen, Ann D, Crary, John F, Dage, Jeffrey L, Diaz, Kristophe, Frost, Bess, Gan, Li, Goate, Alison M, Golbe, Lawrence I, Hansson, Oskar, Karch, Celeste M, Kolb, Hartmuth C, La Joie, Renaud, Lee, Suzee E, Matallana, Diana, Miller, Bruce L, Onyike, Chiadi U, Quiroz, Yakeel T, Rexach, Jessica E, Rohrer, Jonathan D, Rommel, Amy, Sadri‐Vakili, Ghazaleh, Schindler, Suzanne E, Schneider, Julie A, Sperling, Reisa A, Teunissen, Charlotte E, Weninger, Stacie C, Worley, Susan L, Zheng, Hui, and Carrillo, Maria C

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Brain Disorders, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Neurodegenerative, Alzheimer's Disease, Dementia, biomarkers, tau, tau-PET, tauopathies, therapeutics, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionThe pace of innovation has accelerated in virtually every area of tau research in just the past few years.MethodsIn February 2022, leading international tau experts convened to share selected highlights of this work during Tau 2022, the second international tau conference co-organized and co-sponsored by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation.ResultsRepresenting academia, industry, and the philanthropic sector, presenters joined more than 1700 registered attendees from 59 countries, spanning six continents, to share recent advances and exciting new directions in tau research.DiscussionThe virtual meeting provided an opportunity to foster cross-sector collaboration and partnerships as well as a forum for updating colleagues on research-advancing tools and programs that are steadily moving the field forward.

Published
2024

4. APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Author

Ferrari-Souza, João Pedro, Bellaver, Bruna, Ferreira, Pâmela C. L., Benedet, Andréa L., Povala, Guilherme, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Soares, Carolina, Wang, Yi-Ting, Chamoun, Mira, Servaes, Stijn, Macedo, Arthur C., Vermeiren, Marie, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Cohen, Ann, Lopez, Oscar L., Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O., Triana-Baltzer, Gallen, Saad, Ziad S., Kolb, Hartmuth C., Karikari, Thomas K., Villemagne, Victor L., Tudorascu, Dana L., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
Full Text
View/download PDF

5. A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases

Author

Brum, Wagner S., Cullen, Nicholas C., Janelidze, Shorena, Ashton, Nicholas J., Zimmer, Eduardo R., Therriault, Joseph, Benedet, Andrea L., Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Servaes, Stijn, Triana-Baltzer, Gallen, Kolb, Hartmuth C., Palmqvist, Sebastian, Stomrud, Erik, Rosa-Neto, Pedro, Blennow, Kaj, and Hansson, Oskar

Published
2023
Full Text
View/download PDF

6. Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Author

Bellaver, Bruna, Povala, Guilherme, Ferreira, Pamela C. L., Ferrari-Souza, João Pedro, Leffa, Douglas T., Lussier, Firoza Z., Benedet, Andréa L., Ashton, Nicholas J., Triana-Baltzer, Gallen, Kolb, Hartmuth C., Tissot, Cécile, Therriault, Joseph, Servaes, Stijn, Stevenson, Jenna, Rahmouni, Nesrine, Lopez, Oscar L., Tudorascu, Dana L., Villemagne, Victor L., Ikonomovic, Milos D., Gauthier, Serge, Zimmer, Eduardo R., Zetterberg, Henrik, Blennow, Kaj, Aizenstein, Howard J., Klunk, William E., Snitz, Beth E., Maki, Pauline, Thurston, Rebecca C., Cohen, Ann D., Ganguli, Mary, Karikari, Thomas K., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
Full Text
View/download PDF

7. Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer’s pathology

Author

Therriault, Joseph, Ashton, Nicholas James, Pola, Ilaria, Triana-Baltzer, Gallen, Brum, Wagner Scheeren, Di Molfetta, Guglielmo, Arslan, Burak, Rahmouni, Nesrine, Tissot, Cecile, Servaes, Stijn, Stevenson, Jenna, Macedo, Arthur Cassa, Pascoal, Tharick Ali, Kolb, Hartmuth Christian, Jeromin, Andreas, Blennow, Kaj, Zetterberg, Henrik, Rosa-Neto, Pedro, and Benedet, Andrea Lessa

Published
2024
Full Text
View/download PDF

8. Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans

Author

Baker, Suzanne L, Provost, Karine, Thomas, Wesley, Whitman, AJ, Janabi, Mustafa, Schmidt, Mark E, Timmers, Maarten, Kolb, Hartmuth C, Rabinovici, Gil D, and Jagust, William J

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Acquired Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Brain Disorders, Neurodegenerative, Biomedical Imaging, Dementia, Neurological, Good Health and Well Being, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Fluorine Radioisotopes, Humans, Isoquinolines, Male, Positron-Emission Tomography, Pyridines, Radiopharmaceuticals, tau Proteins, Alzheimer's disease, [F-18]-JNJ-067, PET, tau, Alzheimer’s disease, [18F]-JNJ-067
Abstract

The [18F]-JNJ-64326067-AAA ([18F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [11C]-PIB amyloid PET scan, and a tau [18F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. The simplified reference tissue model, Logan graphical analysis distribution volume ratio, and SUVR were evaluated for quantification. The [18F]-JNJ-067 tau signal relative to the reference region continued to increase to 90 min, indicating the tracer had not reached steady state. There was no significant difference in any bilateral ROIs for MCIs or PSPs relative to HCs; AD participants showed elevated tracer relative to controls in most cortical ROIs (P

Published
2021

9. Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

Author

Janelidze, Shorena, Stomrud, Erik, Smith, Ruben, Palmqvist, Sebastian, Mattsson, Niklas, Airey, David C, Proctor, Nicholas K, Chai, Xiyun, Shcherbinin, Sergey, Sims, John R, Triana-Baltzer, Gallen, Theunis, Clara, Slemmon, Randy, Mercken, Marc, Kolb, Hartmuth, Dage, Jeffrey L, and Hansson, Oskar

Subjects
Biochemistry and Cell Biology, Biological Sciences, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Brain Disorders, Biomedical Imaging, Acquired Cognitive Impairment, Neurodegenerative, Clinical Research, Alzheimer's Disease, Aging, Neurosciences, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Neurological, Aged, Aged, 80 and over, Alzheimer Disease, Biomarkers, Brain, Carbolines, Contrast Media, Diagnosis, Differential, Feasibility Studies, Female, Humans, Male, Middle Aged, Phosphorylation, Positron-Emission Tomography, Sweden, tau Proteins, Alzheimer's disease, Tauopathy, Small molecule, Mouse model, Immunohistochemistry, Seeding, Neurofibrillary Tangles, Animals, Mice, Transgenic, Mice, Disease Models, Animal, Amyloid beta-Peptides, Alzheimer’s disease, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundMolecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein aggregation. A lead MT, called CLR01, has been demonstrated to inhibit the aggregation and toxicity of multiple amyloidogenic proteins in vitro and in vivo. Previously, we evaluated the effect of CLR01 in the 3 × Tg mouse model of Alzheimer's disease, which overexpresses mutant human presenilin 1, amyloid β-protein precursor, and tau and found that subcutaneous administration of the compound for 1 month led to a robust reduction of amyloid plaques, neurofibrillary tangles, and microgliosis. CLR01 also has been demonstrated to inhibit tau aggregation in vitro and tau seeding in cell culture, yet because in Alzheimer's disease (AD) and in the 3 × Tg model, tau hyperphosphorylation and aggregation are thought to be downstream of Aβ insults, the study in this model left open the question whether CLR01 affected tau in vivo directly or indirectly.MethodsTo determine if CLR01 could ameliorate tau pathology directly in vivo, we tested the compound similarly using the P301S-tau (line PS19) mouse model. Mice were administered 0.3 or 1.0 mg/kg per day CLR01 and tested for muscle strength and behavioral deficits, including anxiety- and disinhibition-like behavior. Their brains then were analyzed by immunohistochemical and biochemical assays for pathological forms of tau, neurodegeneration, and glial pathology.ResultsCLR01 treatment ameliorated muscle-strength deterioration, anxiety-, and disinhibition-like behavior. Improved phenotype was associated with decreased levels of pathologic tau forms, suggesting that CLR01 exerts a direct effect on tau in vivo. Limitations of the study included a relatively short treatment period of the mice at an age in which full pathology is not yet developed. In addition, high variability in this model lowered the statistical significance of the findings of some outcome measures.ConclusionsThe findings suggest that CLR01 is a particularly attractive candidate for the treatment of AD because it targets simultaneously the two major pathogenic proteins instigating and propagating the disease, amyloid β-protein (Aβ), and tau, respectively. In addition, our study suggests that CLR01 can be used for the treatment of other tauopathies in the absence of amyloid pathology.

Published
2021

13. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author

Wlazly, Dominika, Dickinson, Amber, Foster, Andy, Knight, Clare, Leckey, Claire, Morgan, Paul, Morgan, Angharad, O'Hagan, Caroline, Touchard, Samuel, Khan, Shahid, Murphy, Phil, Parker, Christine, Patel, Jai, Richardson, Jill, Acton, Paul, Austin, Nigel, Bhattacharya, Anindya, Carruthers, Nick, de Boer, Peter, Drevets, Wayne, Isaac, John, Jones, Declan, Kemp, John, Kolb, Hartmuth, Nye, Jeff, Wittenberg, Gayle, Barker, Gareth, Bogdanova, Anna, Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Enache, Daniela, Gee, Tony, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Pariante, Carmine, Randall, Karen, Schubert, Julia, Sforzini, Luca, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Turkheimer, Federico, Van Loo, Vicky, Veronese, Mattia, Rodriguez, Marta Vicente, Wood, Toby, Worrell, Courtney, Zajkowska, Zuzanna, Campbell, Brian, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Moeller, Thomas, Nelson, Bob, Plath, Niels, Thomsen, Christian, Pederson, Jan Torleif, Zorn, Stevin, Deith, Catherine, Farmer, Scott, McClean, John, McPherson, Andrew, Penandes, Nagore, Scouller, Paul, Sutherland, Murray, Attenburrow, Mary Jane, Benjamin, Jithen, Jones, Helen, Mada, Fran, Oladejo, Akintayo, Smith, Katy, Balice-Gordon, Rita, Binneman, Brendon, Duerr, James, Fullerton, Terence, Goli, Veeru, Hughes, Zoe, Piro, Justin, Samad, Tarek, Sporn, Jonathan, Hoskins, Liz, Kohn, Charmaine, Wilcock, Lauren, Aigbirhio, Franklin, Bhatti, Junaid, Bullmore, Ed, Chamberlain, Sam, Correia, Marta, Crofts, Anna, Fryer, Tim, Graves, Martin, Hatton, Alex, Kitzbichler, Manfred, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy, Cavanagh, Jonathan, McColl, Alison, Shaw, Robin, Boddeke, Erik, Baird, Alison, Clare, Stuart, Cowen, Phil, Huang, I-Shu (Dante), Hurley, Sam, Lovestone, Simon, Nevado-Holgado, Alejo, Ribe, Elena, Vyas, Anviti, Winchester, Laura, Cleal, Madeleine, Gomez-Nicola, Diego, Mancuso, Renzo, Perry, Hugh, Cercignani, Mara, Clarke, Charlotte, Colasanti, Alessandro, Harrison, Neil, Murray, Rosemary, O'Connor, Jason, Mount, Howard, Schubert, Julia J., Fryer, Tim D., Manavaki, Roido, Kitzbichler, Manfred G., Nettis, Maria A., Pariante, Carmine M., Bullmore, Edward T., and Turkheimer, Federico E.

Published
2021
Full Text
View/download PDF

15. Alzheimer's Disease biological PET staging using plasma p217+tau

Author

Feizpour, Azadeh, primary, Dore, Vincent, additional, Krishnadas, Natasha, additional, Bourgeat, Pierrick, additional, Doecke, James D., additional, Saad, Ziad, additional, Triana-Baltzer, Gallen, additional, Laws, Simon M., additional, Shishegar, Rosita, additional, Huang, Kun, additional, Fowler, Christopher, additional, Ward, Larry, additional, Masters, Colin L., additional, Mejan-Fripp, Jurgen, additional, Kolb, Hartmuth C., additional, Villemagne, Victor L., additional, and Rowe, Christopher C., additional

Published
2024
Full Text
View/download PDF

16. Novel avenues of tau research

Author

Sexton, Claire E., primary, Bitan, Gal, additional, Bowles, Kathryn R., additional, Brys, Miroslaw, additional, Buée, Luc, additional, Maina, Mahmoud Bukar, additional, Clelland, Claire D., additional, Cohen, Ann D., additional, Crary, John F., additional, Dage, Jeffrey L., additional, Diaz, Kristophe, additional, Frost, Bess, additional, Gan, Li, additional, Goate, Alison M, additional, Golbe, Lawrence I., additional, Hansson, Oskar, additional, Karch, Celeste M., additional, Kolb, Hartmuth C., additional, La Joie, Renaud, additional, Lee, Suzee E., additional, Matallana, Diana, additional, Miller, Bruce L., additional, Onyike, Chiadi U., additional, Quiroz, Yakeel T., additional, Rexach, Jessica E., additional, Rohrer, Jonathan D., additional, Rommel, Amy, additional, Sadri‐Vakili, Ghazaleh, additional, Schindler, Suzanne E., additional, Schneider, Julie A., additional, Sperling, Reisa A., additional, Teunissen, Charlotte E., additional, Weninger, Stacie C., additional, Worley, Susan L., additional, Zheng, Hui, additional, and Carrillo, Maria C., additional

Published
2024
Full Text
View/download PDF

17. Plasma pTau217: single vs multiple phospho‐site assays.

Author

Benedet, Andrea L., primary, Pola, Ilaria, additional, Triana‐Baltzer, Gallen, additional, Molfetta, Guglielmo Di, additional, Arslan, Burak, additional, Rahmouni, Nesrine, additional, Tissot, Cécile, additional, Therriault, Joseph, additional, Servaes, Stijn, additional, Pascoal, Tharick A., additional, Kolb, Hartmuth C., additional, Jeromin, Andreas, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Ashton, Nicholas J., additional, and Rosa‐Neto, Pedro, additional

Published
2023
Full Text
View/download PDF

18. Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer’s disease

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Benedet, Andrea Lessa, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Souza, Diogo O., additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Pascoal, Tharick A., additional, and Zimmer, Eduardo R, additional

Published
2023
Full Text
View/download PDF

19. Update to the comparative analytical performance of plasma Aβ assays and their relationship to amyloid PET

Author

Zicha, Stephen, primary, Saad, Ziad S., additional, Shaw, Leslie M., additional, Bannon, Anthony W., additional, Rubel, Carrie E., additional, Schindler, Suzanne E., additional, Dobler, Iwona, additional, Du‐Cuny, Lei, additional, Giardina, Sarah F., additional, Kolb, Hartmuth C., additional, Meyers, Emily A., additional, Mordashova, Yulia, additional, Raunig, David L., additional, Rosenbaugh, Erin G., additional, Weber, Christopher J., additional, Zhang, Hang, additional, Zetterberg, Henrik, additional, and Potter, William Z., additional

Published
2023
Full Text
View/download PDF

20. APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Benedet, Andrea Lessa, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Klunk, William E, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Karikari, Thomas K, additional, Villemagne, Victor L, additional, Tudorascu, Dana, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
Full Text
View/download PDF

21. Fast accumulators of tau have higher levels of plasma pTau and stronger associations with amyloid in later Braak regions at baseline

Author

Servaes, Stijn, primary, Tissot, Cécile, additional, Therriault, Joseph, additional, Lussier, Firoza Z, additional, Ashton, Nicholas J., additional, Benedet, Andrea Lessa, additional, Karikari, Thomas K, additional, Wang, Yi‐Ting, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Stevenson, Alyssa, additional, Pallen, Vanessa, additional, Arias, Jaime Fernandez, additional, Macedo, Arthur C., additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa‐Neto, Pedro, additional

Published
2023
Full Text
View/download PDF

23. Plasma biomarkers of tau for the differentiation between slow and fast tau‐PET accumulators

Author

Tissot, Cécile, primary, Therriault, Joseph, additional, Rahmouni, Nesrine, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Wang, Yi‐Ting, additional, Stevenson, Jenna, additional, Snellman, Anniina, additional, Rodriguez, Juan Lantero, additional, Stevenson, Alyssa, additional, Arias, Jaime Fernandez, additional, Lussier, Firoza Z, additional, Chamoun, Mira, additional, Mathotaarachchi, Sulantha, additional, Bezgin, Gleb, additional, Kunach, Peter, additional, Triana‐Baltzer, Gallen, additional, Gauthier, Serge, additional, Karikari, Thomas K, additional, Kolb, Hartmuth C., additional, Benedet, Andrea Lessa, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Pascoal, Tharick Ali, additional, Ashton, Nicholas J., additional, and Rosa‐Neto, Pedro, additional

Published
2023
Full Text
View/download PDF

24. Prognostic utility of plasma p217+tau vs amyloid and tau PET in the Alzheimer’s continuum

Author

Feizpour, Azadeh, primary, Dore, Vincent, additional, Doecke, James D, additional, Saad, Ziad S., additional, Triana‐Baltzer, Gallen, additional, Krishnadas, Natasha, additional, Fowler, Christopher J, additional, Ward, Larry, additional, Martins, Ralph N, additional, Masters, Colin L, additional, Villemagne, Victor L, additional, Fripp, Jurgen, additional, Kolb, Hartmuth C., additional, and Rowe, Christopher C, additional

Published
2023
Full Text
View/download PDF

26. Harmonization of tau‐PET in Alzheimer’s disease: comparison of methods to derive CenTauR units for [18F]RO948, [18F]Flortaucipir, and [18F]MK‐6240

Author

Leuzy, Antoine, primary, Dore, Vincent, additional, Raket, Lars Lau, additional, Klein, Gregory, additional, Baker, Suzanne L., additional, Carrillo, Maria C., additional, Charil, Arnaud, additional, Collins, Emily C., additional, Collins, Jessica A., additional, Haeberlein, Samantha Budd, additional, Higuchi, Makoto, additional, Hostetler, Eric D., additional, Hutchison, R. Matthew, additional, Iaccarino, Leonardo, additional, Irizarry, Michael C., additional, Jagust, William J., additional, Johnson, Keith A., additional, Karten, Yashmin, additional, Kolb, Hartmuth C., additional, Lopresti, Brian J., additional, Mathotaarachchi, Sulantha, additional, Mintun, Mark A., additional, Ossenkoppele, Rik, additional, Pappas, Ioannis, additional, Pascoal, Tharick A., additional, Pontecorvo, Michael J., additional, Rabinovici, Gil D., additional, Rosa‐Neto, Pedro, additional, Saad, Ziad S., additional, Bohorquez, Sandra Sanabria, additional, Stephens, Andrew W., additional, Sivakumaran, Sudhir, additional, Tonietto, Matteo, additional, Smith, Ruben, additional, Rowe, Christopher C, additional, Villemagne, Victor L, additional, and Hansson, Oskar, additional

Published
2023
Full Text
View/download PDF

27. Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer’s disease individuals

Author

Ferreira, Pamela C.L., primary, Bellaver, Bruna, additional, Povala, Guilherme, additional, Therriault, Joseph, additional, Ferrari‐Souza, João Pedro, additional, Tissot, Cécile, additional, Leffa, Douglas Teixeira, additional, Brum, Wagner S., additional, Benedet, Andrea Lessa, additional, Lussier, Firoza Z, additional, Cabrera, Arlec, additional, Zalzale, Hussein, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Stevenson, Jenna, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Cohen, Ann D., additional, Gauthier, Serge, additional, Zimmer, Eduardo R., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Karikari, Thomas K, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
Full Text
View/download PDF

28. Plasma ALZpath p‐tau217 for the identification of amyloid and tau positivity

Author

Ashton, Nicholas J., primary, Molfetta, Guglielmo Di, additional, Brum, Wagner Scheeren, additional, Benedet, Andrea Lessa, additional, Arslan, Burak, additional, Jonaitis, Erin M., additional, Langhough, Rebecca E, additional, Cody, Karly Alex, additional, Betthauser, Tobey J, additional, Hogan, Kirk J., additional, Christian, Bradley T., additional, Rahmouni, Nesrine, additional, Stevenson, Jenna, additional, Montoliu‐Gaya, Laia, additional, Rodriguez, Juan Lantero, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Vanbrabant, Jeroen, additional, Stoops, Erik, additional, Jeromin, Andreas, additional, Rosa‐Neto, Pedro, additional, Johnson, Sterling C, additional, Blennow, Kaj, additional, and Zetterberg, Henrik, additional

Published
2023
Full Text
View/download PDF

30. Inflammatory biomarkers in Alzheimer's disease plasma

Author

Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Correia, Marta M., Crofts, Anna L., Dickinson, Amber, Foster, Andrew C., Kitzbichler, Manfred G., Knight, Clare, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda J., St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Touchard, Samuel, Cavanagh, Jonathan, Deith, Catherine, Farmer, Scott, McClean, John, McColl, Alison, McPherson, Andrew, Scouller, Paul, Sutherland, Murray, Boddeke, H.W.G.M., Richardson, Jill C., Khan, Shahid, Murphy, Phil, Parker, Christine A., Patel, Jai, Jones, Declan, de Boer, Peter, Kemp, John, Drevets, Wayne C., Nye, Jeffrey S., Wittenberg, Gayle, Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Turkheimer, Federico, Barker, Gareth J., Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Gee, Antony, Hastings, Caitlin, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Randall, Karen, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Wood, Tobias C., Worrell, Courtney, Zajkowska, Zuzanna, Plath, Niels, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Thomsen, Christian, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Hurley, Samuel, Jones, Helen, Lovestone, Simon, Mada, Francisca, Nevado-Holgado, Alejo, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Hughes, Zoe, Balice-Gordon, Rita, Duerr, James, Piro, Justin R., Sporn, Jonathan, Perry, V. Hugh, Cleal, Madeleine, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Harrison, Neil A., Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Kohn, Charmaine, Murray, Rosemary, Wilcock, Lauren, Wlazly, Dominika, Mount, Howard, Leckey, Claire, Nevado-Holgado, Alejo J., Barkhof, Frederik, Bertram, Lars, Blin, Olivier, Bos, Isabelle, Dobricic, Valerija, Engelborghs, Sebastiaan, Frisoni, Giovanni, Frölich, Lutz, Gabel, Silvey, Johannsen, Peter, Kettunen, Petronella, Kłoszewska, Iwona, Legido-Quigley, Cristina, Lleó, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Molinuevo, José Luis, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Sala, Isabel, Scheltens, Philip, Streffer, Johannes, Soininen, Hikka, Tainta-Cuezva, Mikel, Teunissen, Charlotte, Tsolaki, Magda, Vandenberghe, Rik, Visser, Pieter Jelle, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, and Zetterberg, Henrik

Published
2019
Full Text
View/download PDF

31. Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

Author

Chien, David T, Szardenings, A Katrin, Bahri, Shadfar, Walsh, Joseph C, Mu, Fanrong, Xia, Chunfang, Shankle, William R, Lerner, Alan J, Su, Min-Ying, Elizarov, Arkadij, and Kolb, Hartmuth C

Subjects
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Neurodegenerative, Alzheimer's Disease Related Dementias (ADRD), Aging, Brain Disorders, Neurosciences, Acquired Cognitive Impairment, Frontotemporal Dementia (FTD), Dementia, Biomedical Imaging, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Neurological, Aged, Aged, 80 and over, Alzheimer Disease, Benzimidazoles, Brain, Brain Mapping, Female, Fluorodeoxyglucose F18, Humans, Male, Mental Status Schedule, Middle Aged, Positron-Emission Tomography, Pyrimidines, Time Factors, tau Proteins, Alzheimer's disease, amyloid-beta, brain imaging, mild cognitive impairment, molecular imaging, neurofibrillary tangles, PHF-tau, tau, tau aggregates, tauopathy, amyloid-β, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.

Published
2014

32. The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Author

Knopman, David S., Haeberlein, Samantha Budd, Carrillo, Maria C., Hendrix, James A., Kerchner, Geoff, Margolin, Richard, Maruff, Paul, Miller, David S., Tong, Gary, Tome, Maria B., Murray, Melissa E., Nelson, Peter T., Sano, Mary, Mattsson, Niklas, Sultzer, David L., Montine, Thomas J., Jack, Clifford R., Jr., Kolb, Hartmuth, Petersen, Ronald C., Vemuri, Prashanthi, Canniere, Megan Zoschg, Schneider, Julie A., Resnick, Susan M., Romano, Gary, van Harten, Argonde Corien, Wolk, David A., Bain, Lisa J., and Siemers, Eric

Published
2018
Full Text
View/download PDF

34. Flow optimization study of a batch microfluidics PET tracer synthesizing device

Author

Elizarov, Arkadij M, Meinhart, Carl, Miraghaie, Reza, van Dam, R Michael, Huang, Jiang, Daridon, Antoine, Heath, James R, and Kolb, Hartmuth C

Subjects
Fluid Mechanics and Thermal Engineering, Engineering, Biomedical Imaging, Bioengineering, Indicators and Reagents, Microfluidic Analytical Techniques, Microtechnology, Models, Theoretical, Positron-Emission Tomography, Radioactive Tracers, Flow optimization, Microfluidic, Positron emission tomography, Fluorescence imaging, Microreactor, Numerical modeling, Biomedical Engineering, Materials Engineering, Analytical Chemistry, Biomedical engineering, Nanotechnology
Abstract

We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.

Published
2011

35. Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics

Author

Lee, Chung-Cheng, Sui, Guodong, Elizarov, Arkadij, Shu, Chengyi Jenny, Shin, Young-Shik, Dooley, Alek N., Huang, Jiang, Daridon, Antoine, Wyatt, Paul, Stout, David, Kolb, Hartmuth C., Witte, Owen N., Satyamurthy, Nagichettiar, Heath, James R., Phelps, Michael E., Quake, Stephen R., and Tseng, Hsian-Rong

Published
2005

37. Plasma phosphorylated tau‐217 exhibits sex‐specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults

Author

Saloner, Rowan, primary, VandeVrede, Lawren, additional, Asken, Breton M., additional, Paolillo, Emily W., additional, Gontrum, Eva Q., additional, Wolf, Amy, additional, Lario‐Lago, Argentina, additional, Milà‐Alomà, Marta, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Dubal, Dena B., additional, Rabinovici, Gil D., additional, Miller, Bruce L., additional, Boxer, Adam L., additional, Casaletto, Kaitlin B., additional, and Kramer, Joel H., additional

Published
2023
Full Text
View/download PDF

38. Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individuals

Author

Ferreira, Pamela C. L., primary, Therriault, Joseph, additional, Tissot, Cécile, additional, Ferrari‐Souza, João Pedro, additional, Benedet, Andréa L., additional, Povala, Guilherme, additional, Bellaver, Bruna, additional, Leffa, Douglas T., additional, Brum, Wagner S., additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Vermeiren, Marie, additional, Macedo, Arthur C., additional, Cabrera, Arlec, additional, Stevenson, Jenna, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth, additional, Rahmouni, Nesrine, additional, Klunk, William E., additional, Lopez, Oscar L., additional, Villemagne, Victor L., additional, Cohen, Ann, additional, Tudorascu, Dana L., additional, Zimmer, Eduardo R., additional, Karikari, Thomas K., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Gauthier, Serge, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
Full Text
View/download PDF

40. Plasma pTau‐217 and N‐terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid‐β positive individuals.

Author

Woo, Marcel S., Tissot, Cécile, Lantero‐Rodriguez, Juan, Snellman, Anniina, Therriault, Joseph, Rahmouni, Nesrine, Macedo, Arthur C., Servaes, Stijn, Wang, Yi‐Ting, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Chamoun, Mira, Lussier, Firoza Z., Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Triana‐Baltzer, Gallen, Kolb, Hartmuth C., Stevenson, Jenna, and Mayer, Christina

Abstract

INTRODUCTION: We set out to identify tau PET‐positive (A+T+) individuals among amyloid‐beta (Aβ) positive participants using plasma biomarkers. METHODS: In this cross‐sectional study we assessed 234 participants across the AD continuum who were evaluated by amyloid PET with [18F]AZD4694 and tau‐PET with [18F]MK6240 and measured plasma levels of total tau, pTau‐181, pTau‐217, pTau‐231, and N‐terminal tau (NTA‐tau). We evaluated the performances of plasma biomarkers to predict tau positivity in Aβ+ individuals. RESULTS: Highest associations with tau positivity in Aβ+ individuals were found for plasma pTau‐217 (AUC [CI95%] = 0.89 [0.82, 0.96]) and NTA‐tau (AUC [CI95%] = 0.88 [0.91, 0.95]). Combining pTau‐217 and NTA‐tau resulted in the strongest agreement (Cohen's Kappa = 0.74, CI95% = 0.57/0.90, sensitivity = 92%, specificity = 81%) with PET for classifying tau positivity. DISCUSSION: The potential for identifying tau accumulation in later Braak stages will be useful for patient stratification and prognostication in treatment trials and in clinical practice. Highlights: We found that in a cohort without pre‐selection pTau‐181, pTau‐217, and NTA‐tau showed the highest association with tau PET positivity.We found that in Aβ+ individuals pTau‐217 and NTA‐tau showed the highest association with tau PET positivity.Combining pTau‐217 and NTA‐tau resulted in the strongest agreement with the tau PET‐based classification. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

41. Plasma phosphorylated tau‐217 exhibits sex‐specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.

Author

Saloner, Rowan, VandeVrede, Lawren, Asken, Breton M., Paolillo, Emily W., Gontrum, Eva Q., Wolf, Amy, Lario‐Lago, Argentina, Milà‐Alomà, Marta, Triana‐Baltzer, Gallen, Kolb, Hartmuth C., Dubal, Dena B., Rabinovici, Gil D., Miller, Bruce L., Boxer, Adam L., Casaletto, Kaitlin B., and Kramer, Joel H.

Abstract

INTRODUCTION: Accumulating evidence indicates disproportionate tau burden and tau‐related clinical progression in females. However, sex differences in plasma phosphorylated tau (p‐tau)217 prediction of subclinical cognitive and brain changes are unknown. METHODS: We measured baseline plasma p‐tau217, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) in 163 participants (85 cognitively unimpaired [CU], 78 mild cognitive impairment [MCI]). In CU, linear mixed effects models examined sex differences in plasma biomarker prediction of longitudinal domain‐specific cognitive decline and brain atrophy. Cognitive models were repeated in MCI. RESULTS: In CU females, baseline plasma p‐tau217 predicted verbal memory and medial temporal lobe trajectories such that trajectories significantly declined once p‐tau217 concentrations surpassed 0.053 pg/ml, a threshold that corresponded to early levels of cortical amyloid aggregation in secondary amyloid positron emission tomography analyses. CU males exhibited similar rates of cognitive decline and brain atrophy, but these trajectories were not dependent on plasma p‐tau217. Plasma GFAP and NfL exhibited similar female‐specific prediction of medial temporal lobe atrophy in CU. Plasma p‐tau217 exhibited comparable prediction of cognitive decline across sex in MCI. DISCUSSION: Plasma p‐tau217 may capture earlier Alzheimer's disease (AD)‐related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

42. Harmonization of tau‐PET in Alzheimer's disease: comparison of methods to derive CenTauR units for [18F]RO948, [18F]Flortaucipir, and [18F]MK‐6240.

Author

Leuzy, Antoine, Dore, Vincent, Raket, Lars Lau, Klein, Gregory, Baker, Suzanne L., Carrillo, Maria C., Charil, Arnaud, Collins, Emily C., Collins, Jessica A., Haeberlein, Samantha Budd, Higuchi, Makoto, Hostetler, Eric D., Hutchison, R. Matthew, Iaccarino, Leonardo, Irizarry, Michael C., Jagust, William J., Johnson, Keith A., Karten, Yashmin, Kolb, Hartmuth C., and Lopresti, Brian J.

Abstract

Background: Tau positron emission tomography (PET) is increasingly used in the clinical evaluation of patients and as an outcome measure in Alzheimer's disease (AD) clinical trials. Due to differences in tracer properties, instrumentation, and methods of analysis, however, tau‐PET outcome data cannot currently be meaningfully compared or combined. Here, we tested i) the feasibility of adapting the Centiloid method—an approach originally developed to standardize amyloid PET—to harmonize tau‐PET quantification (CenTauRs); ii) the performance of a non‐linear mixed model‐based approach (Joint Propagation Model) that does not require the use of a reference tracer. Methods: Head‐to‐head tau‐PET data (Table 1) was included from two cohorts ([18F]RO948 vs [18F]flortaucipir, n = 37 [BioFINDER‐2]; [18F]flortaucipir [Avid A05] vs [18F]MK‐6240, n = 15, University of Pittsburgh) in which each participant was scanned with two tau‐PET tracers. Standardized uptake value ratio (SUVR) values were calculated using the inferior cerebellar cortex as the reference region. Anchor point data (Table 1) was derived for each tracer using the following criteria: CenTauR‐0, cognitively unimpaired (CU), amyloid PET negative (<10 Centiloids); CenTauR‐100, amyloid PET positive (>50 Centiloids), typical (temporoparietal) AD pattern on tau‐PET visual read, age<65 andMMSE>20. Regions‐of‐interest (ROIs) included a universal tau‐PET ROI—based on the intersection of tracer specific ([18F]flortaucipir, [18F]MK‐6240, [18F]PI‐2620, [18F]PM‐PBB3, [18F]GTP1 and [18F]RO948) masks that had been derived by subtracting average of amyloid‐negative CU images from the average AD image—as well as four subregions delineated within this ROI (medial temporal, meta‐temporal, temporoparietal and frontal) (Figure 1A). An overview of the adapted Centiloid‐like approach and the joint propagation model is shown in Figure 1B. Results: High R2 values were observed between tracers across all ROIs: [18F]RO948 vs [18F]flortaucipir, average 0.965 [range 0.923 (frontal) to 0.986 (universal)]; [18F]MK‐6240 vs [18F]flortaucipir, average 0.985 [range, 0.923 (medial temporal) to 0.991 (frontal)]. The Centiloid‐like and joint propagation model approaches provided near identical CenTauR values (Figure 2). Conclusions: Preliminary findings support the development of standardized scale for tau‐PET using both a Centiloid‐like or joint propagation model approach. Additional data and consideration of the advantages and disadvantages of each will be needed to recommend one approach over the other. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

43. Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease

Author

Therriault, Joseph, primary, Servaes, Stijn, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Ashton, Nicholas J., additional, Benedet, Andréa Lessa, additional, Karikari, Thomas K., additional, Macedo, Arthur C., additional, Lussier, Firoza Z., additional, Stevenson, Jenna, additional, Wang, Yi‐Ting, additional, Fernandez‐Arias, Jaime, additional, Stevenson, Alyssa, additional, Socualaya, Kely Quispialaya, additional, Haeger, Arlette, additional, Nazneen, Tahnia, additional, Aumont, Étienne, additional, Hosseini, Ali, additional, Rej, Soham, additional, Vitali, Paolo, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Soucy, Jean‐Paul, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa‐Neto, Pedro, additional

Published
2023
Full Text
View/download PDF

45. Revealing the combined roles of Aβ and tau in Alzheimer’s disease via a pathophysiological activity decoder

Author

Sanchez-Rodriguez, Lazaro M., primary, Bezgin, Gleb, additional, Carbonell, Felix, additional, Therriault, Joseph, additional, Fernandez-Arias, Jaime, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Tissot, Cecile, additional, Stevenson, Jenna, additional, Karikari, Thomas K., additional, Ashton, Nicholas J., additional, Benedet, Andréa L., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Triana-Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Rosa-Neto, Pedro, additional, and Iturria-Medina, Yasser, additional

Published
2023
Full Text
View/download PDF

46. Two-year prognostic utility of plasma p217+tau across the Alzheimer’s continuum

Author

Feizpour, Azadeh, primary, Doré, Vincent, additional, Doecke, James D., additional, Saad, Ziad S., additional, Triana-Baltzer, Gallen, additional, Slemmon, Randy, additional, Maruff, Paul, additional, Krishnadas, Natasha, additional, Bourgeat, Pierrick, additional, Huang, Kun, additional, Fowler, Christopher, additional, Rainey-Smith, Stephanie R., additional, Bush, Ashley I., additional, Ward, Larry, additional, Robertson, Joanne, additional, Martins, Ralph N., additional, Masters, Colin L., additional, Villemagne, Victor L., additional, Fripp, Jurgen, additional, Kolb, Hartmuth C., additional, and Rowe, Christopher C., additional

Published
2023
Full Text
View/download PDF

47. Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography

Author

Therriault, Joseph, primary, Vermeiren, Marie, additional, Servaes, Stijn, additional, Tissot, Cécile, additional, Ashton, Nicholas J., additional, Benedet, Andréa Lessa, additional, Karikari, Thomas K., additional, Lantero-Rodriguez, Juan, additional, Brum, Wagner S., additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Kunach, Peter, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Socualaya, Kely Quispialaya, additional, Macedo, Arthur C., additional, Ferrari-Souza, João Pedro, additional, Ferreira, Pâmela C. L., additional, Bellaver, Bruna, additional, Leffa, Douglas T., additional, Zimmer, Eduardo R., additional, Vitali, Paolo, additional, Soucy, Jean-Paul, additional, Triana-Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Pascoal, Tharick A., additional, Saha-Chaudhuri, Paramita, additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2023
Full Text
View/download PDF

48. APOEε4 potentiates Aβ effects on longitudinal tangle accumulation via tau phosphorylation

Author

Ferrari-Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pâmela, additional, Benedet, Andrea, additional, Povala, Guilherme, additional, Lussier, Firoza, additional, Leffa, Douglas, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Wang, Yi-Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur, additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina, additional, Cohen, Ann, additional, Lopez, Oscar, additional, Klunk, William, additional, Soucy, Jean-Paul, additional, Gauthier, Serge, additional, Souza, Diogo, additional, Triana-Baltzer, Gallen, additional, Saad, Ziad, additional, Kolb, Hartmuth, additional, Karikari, Thomas, additional, Villemagne, Victor, additional, Tudorascu, Dana, additional, Ashton, Nicholas, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo, additional, Rosa-Neto, Pedro, additional, and Pascoal, Tharick, additional

Published
2023
Full Text
View/download PDF

49. Comparison of Two Plasma P-Tau217 Assays to Detect and Monitor Alzheimer's Pathology

Author

Therriault, Joseph, primary, Ashton, Nicholas J., additional, Pola, Ilaria, additional, Triana-Baltzer, Gallen, additional, Di Molfetta, Guglielmo, additional, Arslan, Burak, additional, Rahmouni, Nesrine, additional, Tissot, Cecile, additional, Servaes, Stijn, additional, Stevensson, Jenna, additional, Macedo, Arthur C., additional, Pascoal, Tharick A., additional, Kolb, Hartmuth C., additional, Jeromin, Andreas, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Rosa-Neto, Pedro, additional, and Benedet, Andrea L., additional

Published
2023
Full Text
View/download PDF

50. A head‐to‐head comparison of plasma phosphorylated tau assays in the real‐world memory clinic

Author

Suárez‐Calvet, Marc, primary, Ashton, Nicholas J., additional, Puig‐Pijoan, Albert, additional, Milà‐Alomà, Marta, additional, Fernández‐Lebrero, Aida, additional, García‐Escobar, Greta, additional, González‐Ortiz, Fernándo, additional, Kac, Przemyslaw Radoslaw, additional, Brum, Wagner Scheeren, additional, Benedet, Andréa Lessa, additional, Rodriguez, Juan Lantero, additional, Day, Theresa A., additional, Dage, Jeffrey L., additional, Vanbrabant, Jeroen, additional, Stoops, Erik, additional, Vanmechelen, Eugeen, additional, Triana‐Baltzer, Gallen, additional, Moughadam, Setareh, additional, Kolb, Hartmuth C., additional, Ortiz‐Romero, Paula, additional, Karikari, Thomas K, additional, Minguillón, Carolina, additional, Sánchez, Juan José Hernández, additional, Navalpotro‐Gómez, Irene, additional, Grau‐Rivera, Oriol, additional, Manero, Rosa María, additional, Puente‐Periz, Víctor, additional, de la Torre, Rafael, additional, Roquer, Jaume, additional, Zetterberg, Henrik, additional, and Blennow, Kaj, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results