Search

Hyperplastic processes in the endometrium are classified as a common gynecological pathology. The drug chavanprash has been shown to improve general bodily resistance, to enhance vital tone of the body. It is endowed with a manifest hepatotropic and antitoxic activity, which fact permits recommending it for use in the combination therapy of hyperplastic processes in the endometrium as well as during the period of rehabilitation in the wake of the course of hormonotherapy.

43 women with physiologically proceeding pregnancy have been examined during 1st, 2nd and 3d terms. The control group consists of 28 practically healthy non-pregnant women. It is stated that during pregnancy essential changes in the function of endocrine glands of mother take place. the appearance of placenta, a new gland of internal secretion, producing choriogonadotropin (CG) as well as the great amount of other hormones of the steroid and protein nature causes essential changes in the regulatory mechanisms underlying the physiological activity of internal secretion glands in mother. The development and early functioning of the internal secretion glands of a fetus promote the hormonal shifts. With the pregnancy development the number of estrogen increases hundred times, relative to their production in non-pregnant women secretion of progesterone and prolactin increase ten times. The functional activity of anterior lobe of the hypophysis, manifesting itself in hypersecretion of adrenocorticotropic hormone inhibition of follicule-stimulating hormone production changes as well. Changes in the functional state of the adrenal gland cortex: cortisole secretion is high are found.

To improve the efficacy of prelabor treatment of pregnant women with some obstetrical abnormalities, such as over-term pregnancy, AB0- and Rh-isosensitization, anemia, gestosis of the second half of pregnancy, vaginal and intracervical suppositories containing 0.1 mg of enzaprost were administered to 102 women for 1-5 days. In 30 (29.4%) cases such treatment induced spontaneous labor. In 64 (62.7%) women labor was induced by deoxy-amino oxytocin, and in 8 (7.8%) women this latter drug had to be administered repeatedly to induce labor. The babies born to the women under observation had the Apgar score of 6-10, 92 (90.2%) of them had the score of 8-10. No stillbirths or early infant mortality cases were recorded. Therefore prelabor treatment with vaginal or intracervical suppositories with enzaprost is effective and safe for both mother and newborn.

A total of 84 women with normal pregnancy and those with threatened abortions were examined, as were 28 healthy nonpregnant women, to estimate the function of the thymus. The findings evidence enhancement of the endocrine function of the thymus in pregnancy, this function being assessed from the thymic serum factor titer. The function activation is related to pregnancy course and is more marked in threatened abortion. Before labor the thymic serum factor titers are the highest and they persist high after spontaneous delivery. The biological sense of thymic hormonal function activation in pregnancy is discussed, as are the possible mechanisms of this phenomenon.

Literature and the authors' evidence concerning effects of umbilical abnormality on maternal and fetal outcomes has been overviewed. It is emphasized that identification of umbilical abnormality during labor and delivery, but not only during pregnancy, will improve obstetric outcomes.

Hysteroscopic features of preinvasive and invasive uterine cancer as well as the adjacent endometrium were studied in 103 patients. The following types of early cancer were identified with regard to pattern of growth: a single lesion, multiple lesions and diffuse involvement of the endometrium. On the basis of hysteroscopic signs, tumors were classified into polypoid, plaque-shaped, cystic mucin-producing forms and tumors with predominant atypical vasculature. Clinically apparent endometrial tumors were hysteroscopically classified as circumscribed and diffuse. The former were further subdivided into nodular, polypoid, papillary and cystic mucin-producing patterns. The credibility of hysteroscopic diagnosis was 81.8% for preinvasive and 100%--for invasive uterine carcinoma. Hysteroscopy proved instrumental in uterine cancer diagnosis, particularly, for the preinvasive form since it allows aiming sampling for histological examination to be carried out.

The effectiveness of treatment of early cancer of the uterine cervix (TIS, Tla and Tlb) is subject to evaluation of tumor stage, concomitant diseases and patient's age as well as the degree of neoplastic process and immunologic vigor. Complex treatment should be unoffensive for immunity. Immunodepressive agents should be used in conjunction with immunostimulants.

The study is concerned with immunologic status (cell-mediated and humoral immunity) as a factor influencing the choice of scheme of treatment for carcinoma of cervix uteri. The indexes of immunocompetence should be taken into account in planning the differential treatment of precancer and early forms of carcinoma of cervix uteri. Radiation treatment exerts an immunosuppressive effect. However, immunologic indexes are not affected considerably by laser destruction or surgery. Cryodestruction has a beneficial effect on cell-mediated immunity. Considering these effects as well as the long-term results of different procedures of treatment, laser coagulation, cryogenic destruction or diathermoconization should be recommended for management of carcinoma in situ of cervix uteri, and extensive extirpation of the uterus, unattended by radiation, for Tla.

Complex clinico-endoscopic and morphological study of the uterine cervix pathology is performed in more than 20 000 women since 1962 up to now. The possibility of correlation between the results of endoscopic tests and those of cytomorphological study of the uterine cervix and cervical channel pathological processes is shown. The limitations of the endoscopic analysis are noted. Endoscopical-morphological classification is suggested and tactics of the patient examination with the risk, pretumourous conditions and early carcinoma is grounded.

The results of colpocervicoscopic examination of more than 15,000 females suggested cervical carcinoma in 345 cases, which was confirmed histologically in 319 patients. A detailed morphological and cytogenetic investigation carried out in 36 patients with preclinical form of TIaNXMO invasive carcinoma of cervix uteri established a relationship of mitotic activity, pathological mitosis count and fraction of cells with X-chromatin, on the one hand, and the depth of tumor invasion, on the other. The stages of complex examination of patients with pathology of cervix uteri are discussed.