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6. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

Author

Abbasciano, Isabella, Abrantes, Catarina, Accarino, Simone, Adler, Sharon, Adoberg, Annika, Afsari, Rouzbeh, Ahmad, Syeda, Ahmed, Jafar, Ahn, Wooin, Ajayi, Bamidele, Aksamit, Dariusz, Al Chalabi, Saif, Alamartine, Eric, Alchi, Bassam, Ali, Mohammad, Aliotta, Roberta, Almaani, Salem, Almeida, Catarina, Almeida, Edgar, Alvarez, Francisco de la Prada, Alves, Patricia, Annese, Francesca, Appel, Gerald, Arduan, Alberto Ortiz, Arena, Maria, Arevalo, Marta Calvo, Arfaania, Dariush, Arias, Carlos, Aristoy, Emma Calatayud, Asakiene, Egle, Ashley, Sarah, Assefi, Ali, Atenza, Alba, Auerbach, Asta, Augustyniak-Bartosik, Hanna, Avella, Monroy, Ayling-Smith, Jonathan, Ayoub, Isabelle, Ayvazyan, Christine, Baccaro, Rocco, Bailey, Asha, Baker, Bruce, Balamuthusamy, Saravanan, Ballarin, Jose, Barata, Rui, Barbic, Jerko, Barisic, Dunja, Barratt, Jonathan, Barreto, Jose Carlos de Jesus, Barrios, Clara, Belingheri, Mirco, Benesova, Anna, Bernabeu, Ana Avila, Bernhardt, Wanja, Bhadra, Shamik, Biancone, Luigi, Blanchard, Anne, Boaglio, Elena, Bolignano, Davide, Bomback, Andrew, Bonilla, Gustavo Andres Useche, Bordoli, Monica, Bose, Bhadran, Boudville, Neil, Brandon, Donald, Brown, Karen, Broyet, Christian, Bucknall, Thomas, Buffet, Alexandre, Bumblyte', Inga Arune, Burdese, Manuel, Burgos, Natalia Allende, Burguet, Laure, Burtey, Stephane, Busch, Martin, Cakiroglu, Figen, Campbell, Victoria, Canetta, Pietro, Capaccio, Flavia, Carbonell, Juan, Cardoso, Filipa, Carro, Clara Garcia, Carroll, Robert, Carron, Pierre-Louis, Carullo, Nazareno, Cassia, Matthias, Caster, Dawn, Castillo, Belen Vizcaino, Catucci, Davide, Cavalli, Andrea, Chae, Dong-Wan, Chakera, Aron, Chan, Doris, Chan, Gary Chi Wang, Chan, Anthony Ting Pong, Chan, Lai Wan, Chang, Jae Hyun, Chang, Ming-Shan, Chapman, Fiona, Charytan, Chaim, Chaudhry, Asghar, Cheetham, Melissa, Chen, Cheng-Hsu, Chen, Hsin-Yu, Chen, Chien-Liang, Chen, Hung-Yuan, Chen, Hung-Chun, Chenine, Leila, Cheung, Siu Fai, Cheung, Chee Kay, Chiche-Jourde, Noemie, Chiu, Hsien-Fu, Chiu, Yen-Ling, Chiu, Yi-Wen, Chiu, Ian, Choi, Hoon Young, Chou, Kang-Ju, Chowdhury, Paramit, Chowdhury, Pradip, Chrysochou, Constantina, Chukwu, Chukwuma, Chun, Ka Yeong, Chung, Wookyung, Cieniawski, Dominik, Claisse, Guillaume, Clayton, Philip, Cleary, Catalina Martín, Clement, Nisha, Coates, Toby, Cogno, Chiara, Colla, Loredana, Collins, Michael, Colucci, Marco, Combe, Christian, Comi, Nicolino, Comunale, Roderick, Contreras, Gabriel, Cooper, Bruce, Coppock, Gaia, Costa, Ana Cortesão, Costanzi, Stefano, Cozzolino, Mario, Crail, Susan, Cunha, Liliana, Curry, Elizabeth, Dai, Tiane, Daina, Erica, Daneshvari, Sam, Dasgupta, Indranil, DaSilva, Louise, Davidson, Robert, De Bhailis, Aine Maire, de Précigout, Valérie, Decupere, Marc, Delmas, Yahsou, Deodato, Francesca, Dhaun, Neeraj, Dhaygude, Ajay, Dhelaria, Ranjit, Di Maio, Federica, Diezhandino, Maria Angeles Goicoechea, Dika, Zivka, Dinic, Miriana, Dittmer, Ian, Dobre, Mirela, Doctor, Gabriel, Donati, Gabriele, Doubel, Peter, Douthit, Nicole, Draganova, Diliana, Drexler, Yelena, Drinkovic, Martin, Drinovska, Klara, Dudreuilh, Caroline, Dumond, Clement, Durlen, Ivan, Dussol, Bertrand, Encarnacion, Montserrat Diaz, Endre, Zoltan, Enrique, Jorge, Eqbal, Yusuf, Erlich, Jonathan, Esposito, Vittoria, Esposito, Ciro, Fakih, Faisal, Fang, Hua-Chang, Farinha, Ana, Fearday, Aaron, Felgueiras, Joana de Sousa Soares, Felicjanczuk, Elzbieta, Fernandes, João Carlos, Fernandes, Sara, Fernandes, Adriana, Fernandez, Jose Luño, Fernandez, Victor, Fernando, Mangalee, Figueiredo, Ana Carolina, Firre, Eric, Floege, Jürgen, Flossmann, Oliver, Floyd, Lauren, Fonseca, Nuno, Fonseca, Jose Nuno de Almeida Agapito, Foote, Celine, Forbes, Suzanne, Forcen, Angel, Fornoni, Alessia, Fouassier, David, Fraser, Ian, Fung, Ka Shun Samuel, Furlano, Monica, Furtado, Teresa, Gadh, Rajdeep, Gaisset, Roxane, Gallagher, Martin, Gameiro, Joana, Gangadharan, Muralikrishna, Garcia, Fabiola Alonso, Garcia, Olga Gracia, Garg, Gunjan, Garrouste, Cyril, Gautam, Archana, Geara, Abdallah, Geddes, Colin, Gellineo, Lana, Germain, Michael, Gesualdo, Loreto, Ghalli, Farid, Giaroni, Francesco, Giles, Harold, Gillies, Alastair, Gimeno, Ana Vilar, Girardet, Annette, Glaze, Jeffrey, Goh, Tze, Gois, Mario, Goldsmith, Christopher, Goma, Elena, Gomes, Ana Marta, Goncalves, Luis Pedro Falcao, Goncalves, Sara, Gontarek-Kacprzak, Julita, Gonzalez, Carlos, Gopu, Arun, Gowda, Nayan, Gray, Nicholas, Greco, Barbara, Green, Heather, Greze, Clarisse, Griffin, Sian, Guldris, Secundino Cigarran, Guzman, Ursula Verdalles, Ha, Jeffrey Tsun Kit, Hall, Amanda, Hamilton, Patrick, Han, Seung Hyeok, Haws, Robert, Hayat, Ashik, Heath, Lauren, Heinrichs, Sven, Henderson, Andrew, Henderson, Amy, Hendren, Elizabeth, Heng, Anne-Elisabeth, Heres, Salia Virxinia Pol, Herfurth, Johann Konstantin, Herrero, Evangelina Merida, Ho, Tzung-Yo, Hogan, Jonathan, Hohenstein, Bernd, Hollett, Peter, Horvatic, Ivica, Hsu, Bang-Gee, Hsu, Chia-Tien, Hsu, Chih-Yang, Hsu, Shih-Ping, Huang, Chien-Wei, Hudson, Amy, Hung, Chi-Chih, Hwang, Shang-Jyh, Hwang, Daw-Yang, Hyun, Young Youl, Ilmoja, Madis, Irish, Georgina, Jacob, Radu, Jahan, Sadia, Jain, Arunima, Jamar, Sofie, Jander, Anna, Jang, Hye Ryoun, Janko, Catherine, Jardine, Meg, Jaskowski, Piotr, Jeantet, Guillaume, Jelakovic, Bojan, Jeon, Junseok, Jeong, Jong Cheol, Jesudason, Shilpanjali, Jittirat, Arksarapuk, Jo, Sang-Kyung, Jones, Rachel, Joo, Narae, Jorge, Sofia, Julian, Bruce, Jung, JiYong, Jyothinagaram, Praveena, Kadakia, Jigar, Kamal, Fahameedah, Kanigicherla, Durga, Karanovic, Sandra, Karras, Alexandre, Kasimatis, Theodoros, Kassem, Mohamad, Kattamanchi, Siddhartha, Keller, Christopher, Kentric, Dubravka Trajbar, Kettner, Christiane, Khalil, Kassem, Kim, Dana, Kim, Se Joong, Kim, Yeong Hoon, Kim, Yunmi, Kim, Hyung Wook, Kim, Sunggyun, Kim, Jwa-Kyung, Kim, Aejin, Kim, Myung-Gyu, Kimber, Cassandra, Klamm, Kathryn, Koch, Annegret, Koester, Eric, Kolvald, Kulli, Kon, Sui, Kooienga, Laura Ann, Kotwal, Sradha, Krajewska, Magdalena, Kratka, Karolina, Krishnan, Anoushka, Krishnasamy, Rathika, Krueger, Thilo, Kruljac, Ivan, Kulka, Simone, Kunzendorf, Ulrich, Kuo, Mei-Chuan, Kuo, Hung-Tien, Kuo, Sheng, Kwan, Lorraine Pui Yuen, Kwella, Norbert, Kwella, Bogna, Kyaw, Kay, Labat, Aurore, Lafayette, Richard, Lagatta, Mark, Lam, Chi Kwan Darwin, Lambie, Mark, Lanaret, Camille, Latif, Farah, Laute, Margo, Law, Wai Ping, Lawman, Sarah, Lazo, Mercedes Salgueira, Lee, Hajeong, Lee, Moon Hyoung, Lee, Kyu-Beck, Lee, Hyung-seok, Lee, JungEun, Lee, Hyun Hee, Lee, Po-Tsang, Leis, Liisi, Lemahieu, Wim, Leung, Janson, Li, Yan, Lie, Davina Ngoi Wah, Lifland, Howard, Lilienthal, Kadri, Lim, Wai, Limardo, Monica, Livrozet, Marine, Longhi, Selena, Lopes, Daniela, Lopes, Jose Antonio, Lorde, Nathan, Luxton, Grant, Ma, Mingyao, Madhrira, Machaiah, Madonia, Phillip, Maes, Bart, Mahadevan, Kumaradevan, Mahdi, Amar, Mahdi, Eamon, Maillard, Nicolas, Maixnerova, Dita, Majstorovic Barac, Karolina, Malecki, Robert, Malfait, Thomas, Malvica, Silvia, Mandayam, Sreedhar, Manley, Paul, Mansfield, Nick, Marcantoni, Carmelita, Mariat, Christophe, Marin, Tamara Malek, Marin, Lida Maria Rodas, Mark, Patrick, Marques, Joana, Martinez, Eduardo Gutierrez, Martinez, Stacy, Masset, Catherine, Masson, Ingrid, Mather, Amanda, Maung Myint, Thida Maung, Mayet, Valentin, McCafferty, Kieran, McCarthy, Ellen, McDonald, Stephen, McGreal, Kerri, McMahon, Kellyn, McNally, Andrew, McQuarrie, Emily, Medina, Allyson, Meeus, Gert, Mehta, Kshama, Mendoza, Elder, Menezes, Maria, Meng, Jerry, Messa, Piergiorgio, Messias, Ana, Miarka, Przemyslaw, Miglinas, Marius, Mikacic, Ivana, Mikhail, Ashraf, Milicevic, Martina, Minasian, Raffi, Moeller, Marcus, Mohey, Hesham, Mojarrab, Javad, Mok, Maggie Ming Yee, Moncasi, Eduardo Parra, Moonen, Martial, Morales, Wenceslao Adrian Aguilera, Moreno, Eduardo Verde, Moreno, Antolina, Morris, Adam, Moutzouris, Dimitrios, Moya, Mercedes Gonzalez, Mucha, Simon, Musolino, Michela, Napodano, Pietro, Natario, Ana, Negrea, Lavinia, Nelson, Bradley, Neuen, Brendon, Newsome, Britt, Ng, Kit Chung Jack, Nguyen, Thu, Nguyen, Viet, Nicolo, Clementine, Nitschke, Martin, Noble, Euan, Nolasco, Fernando, O'Lone, Emma, Ochoa, Adriana Sierra, Oh, Kook-Hwan, Oh, SeWon, Okoh, Pedro, Ombelet, Sara, O'Shaughnessy, Michelle, Ou, Shih-Hsiang, Packham, David, Padiyar, Aparna, Pai, Mei-Fen, Pamplona, Irene Agraz, Pan, Szu-Yu, Pandya, Bhavna, Papadia, Federica, Pardinhas, Clara, Parikh, Nishita, Parikh, Samir, Park, Hyeong Cheon, Park, Jung Tak, Parreira, Lucia, Passerini, Patrizia, Patak, Ramachandra, Patecki, Margret, Patel, Rajan, Patel, Jusmin, Patel Suthar, Meera, Patella, Gemma, Patrikyan, Artashes, Pavlovic, Drasko, Paxton, William, Peh, Chen, Peleg, Yonatan, Pelicano, Josep Miquel Blasco, Peng, Yu-Sen, Pereira de Vicente, Manuel, Perez, Jonay Pantoja, Perez, Erika, Perez de Jose, Ana, Pérez Gómez, María Vanessa, Perez Lluna, Leticia, Peri, Usha, Perico, Norberto, Philipponnet, Carole, Phua, Elaine, Piel, Julia, Pillai, Unnikrishnan, Pilmore, Helen, Plavljanic, Djuro, Plaza, Mercedes Velo, Pollock, Carol, Ponnusamy, Arvind, Ponti, Serena, Powell, Thomas, Pradhan, Nishigandha, Prado, Raul Fernandez, Prkacin, Ingrid, Pruthi, Rishi, Pugh, Dan, Quinn, Sarah, Quintana, Luis F, Raakesh, Lathika, Rabindranath, Kannaiyan, Radermacher, Luc, Radhakrishnan, Jai, Ragy, Omar Sherin Ibrahim, Raichoudhury, Ritesh, Raimundo, Mario, Randone, Paolo, Razavian, Mona, Reichel, Helmut, Reis, Marina, Remuzzi, Giuseppe, Reynolds, Annie, Ricchiuto, Anna, Rico, Ivon Maritza Bobadilla, Rigothier, Claire, Ritchie, Angus, Rivero, Maria Antonieta Azancot, Rizk, Dana, Ro, Han, Rodriguez, Alfred, Rodriguez Garcia, Eva, Roger, Simon, Rony, Mohammad, Rosenberg, Mai, Roueff, Stephane, Rovin, Brad, Roxburgh, Sarah, Ruiz, Mario, Rusinol, Helena Marco, Rychlik, Ivan, Sá, Helena, Salehi, Tania, Sánchez de la Nieta, Maria Dolores, Sanden, Silja, Santockiene, Lina, Santos, Patricia Valerio, Santos, Iara Da Silva, Sargsyan, Mari, Sarnow, Franziska, Sat, Sebahat, Satora, Ewa, Savuk, Ana, Sayer, Matthew, Schlieper, Georg, Schlosser, Mandy, Schmidt-Guertler, Hans, Schockaert, Olivier, Schulte, Kevin, Schulz, Lisa, Selvaskandan, Haresh, Semple, David, Sen, Shaundeep, Seppet, Elviira, Serrano, Antonio Galan, Serre, Jean-Emmanuel, Sevillano, Angel, Shah, Sapna, Shen, Yvonne, Sheridan, Brittany, Shu, Kai-Hsiang, Sightler, Ford, Silva, Sónia, Silva, Arnold, Sinha, Smeeta, Siriwardana, Amanda, Sitas, Zvonimir, Sivo, Carmen, Sizeland, Peter, Sly, Cathylee, Smith, Priscilla, Snow, Brian, Soares, Elsa Sofia Quadrado, Solazzo, Andrea, Solis, Elena Gutierrez, Solomon, Laurence, Song, Young Rim, Sousa, Helena, Spinowitz, Bruce, Stallworthy, Elizabeth, Stamellou, Eleni, Stanczyk, Malgorzata, Stangenberg, Stefanie, Stankovic, Marija, Stankuviene, Asta, Stea, Emma Diletta, Stompor, Tomasz, Storrar, Joshua, Sullivan, James, Sulowicz, Wladyslaw, Suyumova, Irina, Szeto, Cheuk Chun, Tamarit, Esther, Tan, Eddie, Tan, May, Tang, Sydney Chi Wai, Tang, Hon, Teixeira, Catarina, Telling, Kadri, Terrades, Natalia Ramos, Tesar, Vladimir, Tez, Didem, Thervet, Eric, Thibaudin, Damien, Thomas, Mark, Thyagarajan, Nikhil, Tkaczyk, Marcin, Torreggiani, Massimo, Trillini, Matias, Tsai, Shang-Feng, Tsai, Wan-Chuan, Tsai, Jer-Chia, Tseng, Po-Yu, Tumlin, James, Tung, Kuei-Ting, Turnbull, Angus, Udani, Suneel, Uhlinova, Jana, Unt, Kristin, Urciuolo, Federica, Vanacker, An, Vandewiele, Bert, Vaz, Alvaro, Veermae, Kristi, Viaene, Liesbeth, Vickiene, Alvita, Vigano, Sara, Vila, Maria Antonia Munar, Vilayur, Eswari, Villanueva, Caridad Martinez, Villarroya, Cristina Medrano, Villen, Alejandro Soria, Viramontes, Veronica, Vita, Caterina, Vujcic, Dunja, Wahba, Mona, Wan, Susan, Wang, Chih-Hsien, Warling, Xavier, Waters, Gerald, Waugh, Jane, Weiland, Lea, Weiner, Stefan, Weinreich, Thomas, Werth, Stephan Christian, Wickens, Olivia, Wijeratne, Vidu, Wilder, Karen, Willcocks, Lisa, Williams, Allister, Winiarska, Agata, Wirtz, Nikolaus, Wolf, Lothar, Wolf, Gunter, Wong, Muh Geot, Wong, Yick Hei, Wong, Sze Ho Sunny, Workeneh, Biruh, Wu, Ming-Ju, Wu, Hon-Yen, Wyndham, Roger, Yang, Jihyun, Yang, Ju-Yeh, Yeap, Chii, Yim, Ka Fai, Yong, Kenneth, Yoo, Tae-Hyun, Yoon, Songuk, Yu, Tung-Min, Yue, Tak Tai Andrew, Zakari, Michel, Zakauskiene, Urte, Zaoui, Philippe, Zbrzezniak, Justyna, Zielinska, Dorota, Zizzi, Carlotta Federica, Rovin, Brad H, Heerspink, Hiddo J L, Alpers, Charles E, Bieler, Stewart, Diva, Ulysses A, Inrig, Jula K, Kohan, Donald E, Komers, Radko, Małecki, Robert, Mercer, Alex, Noronha, Irene L, Oh, Se Won, Peh, Chen Au, Praga, Manuel, Preciado, Priscila, Rheault, Michelle N, Rote, William E, Tang, Sydney C W, Trachtman, Howard, Trimarchi, Hernán, Tumlin, James A, and Perkovic, Vlado

Published
2023
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10. Lack of renoprotective effects of targeting the endothelin A receptor and (or) sodium glucose transporter 2 in a mouse model of Type 2 diabetic kidney disease

Author

Stuart, Deborah, Peterson, Caitlin S., Hu, Chunyan, Revelo, Monica P., Huang, Yufeng, Kohan, Donald E., and Ramkumar, Nirupama

Subjects
Prevention, Models, Methods, Health aspects, Cell receptors -- Health aspects, Drug targeting -- Methods, Glucose -- Health aspects, Transport proteins -- Health aspects, Endothelin -- Health aspects, Diabetic nephropathies -- Models -- Prevention, Dextrose -- Health aspects, Carrier proteins -- Health aspects
Abstract

Introduction Diabetes mellitus is the leading cause of end-stage kidney disease worldwide (Diabetic Kidney Disease 2021). Until 2019, the only known efficacious therapies for diabetic kidney disease (DKD) were renin [...], Two recent clinical trials, using sodium glucose cotransporter (SGLT2) or endothelin-A receptor (ET-A) blocker, reported the first efficacious treatments in 18 years to slow progression of diabetic kidney disease (DKD). We hypothesized that combined inhibition of SGLT2 and ET-A receptor may confer greater protection against renal injury than either agent alone. Uninephrectomized male db/db mice were randomized to four groups: vehicle, SGLT2 inhibitor (dapagliflozin (dapa), 1 mg/kg/day), ET-A blocker (atrasentan (atra), 5 mg/kg/day), or dual treatment from 10 weeks until 22 weeks of age. At 10 weeks of age, no differences were observed in body weight, blood glucose or urinary albumin excretion among the four groups. At 16 and 22 weeks of age, body weight was lower and blood glucose levels higher in the vehicle and atra groups compared with dapa- and dualtreated groups. No notable differences were observed among the four groups in urinary albumin excretion at weeks 16 and 22. Histological analysis showed mild glomerulosclerosis and tubular injury ( Key words: diabetic kidney disease, SGLT2, endothelin-A receptor, combined therapy A l&apos;aide d&apos;inhibiteurs du cotransporteur sodium-glucose (SGLT2) ou du recepteur A de l&apos;endotheline (ET-A), deux essais cliniques recents ont rapporte les premiers traitements efficaces permettant de ralentir l&apos;evolution de l&apos;insuffisance renale diabetique depuis 18 ans. Nous avons formule une hypothese selon laquelle l&apos;inhibition combinee du SGLT2 et des recepteurs ET-A pourrait apporter une meilleure protection contre les lesions renales que chacun des agents pris isolement. Nous avons reparti des souris db/db males nephrectomisees unilateralement dans 4 groupes : vehicule, dapa (dapaglifozine comme inhibiteur du SGLT2 a 1 mg/kg/jour), atra (atrasentane comme inhibiteur des recepteurs ET-A a 5 mg/kg/jour) ou traitement d&apos;association de l&apos;age de 10 a 22 semaines. A l&apos;age de 10 semaines, nous n&apos;avons observe aucune difference entre les 4 groupes en matiere de masse corporelle, de glycemie ou d&apos;excretion urinaire d&apos;albumine. Aux ages de 16 et de 22 semaines, la masse corporelle etait moins elevee et la glycemie etait plus elevee dans les groupes vehicule et atra que dans le groupe dapa et avec le traitement d&apos;association. Aux semaines 16 et 22, nous n&apos;avons pas observe de difference marquee entre les 4 groupes quant a l&apos;excretion urinaire d&apos;albumine. L&apos;etude histologique a revele la presence d&apos;une legere sclerose glomerulaire et de legeres lesions tubulaires (< 5 %) dans chacun des 4 groupes, malgre une sclerose glomerulaire moins importante avec le traitement d&apos;association qu&apos;avec le vehicule. Dans ce modele, les inhibiteurs du SGLT2 et/ou des recepteurs ET-A n&apos;avaient pas d&apos;effets nephropotecteurs isolement ou en association l&apos;un avec l&apos;autre. [Traduit par la Redaction] Mots-cles : insuffisance renale diabetique, SGLT2, recepteurs A de l&apos;endotheline, traitement d&apos;association

Published
2022

12. Endothelin-targeted new treatments for proteinuric and inflammatory glomerular diseases: focus on the added value to anti-renin-angiotensin system inhibition

Author

Benigni, Ariela, Buelli, Simona, and Kohan, Donald E

Subjects
Drug therapy, Physiological aspects, Development and progression, Health aspects, Pediatric research, Endothelin -- Health aspects -- Physiological aspects, Renin-angiotensin system -- Health aspects -- Physiological aspects, Kidney diseases -- Drug therapy -- Development and progression
Abstract

Author(s): Ariela Benigni [sup.1] , Simona Buelli [sup.1] , Donald E Kohan [sup.2] Author Affiliations: (1) grid.4527.4, 0000000106678902, Istituto di Ricerche Farmacologiche Mario Negri IRCCS Centro Anna Maria Astori, , [...], Chronic kidney disease (CKD) is the main cause of end-stage renal disease worldwide arising as a frequent complication of diabetes, obesity, and hypertension. Current therapeutic options, mainly based of inhibition of the renin-angiotensin system (RAS), provide imperfect renoprotection if started at an advanced phase of the disease, and treatments that show or even reverse the progression of CKD are needed. The endothelin (ET) system contributes to the normal renal physiology; however, robust evidence suggests a key role of ET-1 and its cognate receptors, in the progression of CKD. The effectiveness of ET receptor antagonists in ameliorating renal hemodynamics and fibrosis has been largely demonstrated in different experimental models. A significant antiproteinuric effect of ET receptor antagonists has been found in diabetic and non-diabetic CKD patients even on top of RAS blockade, and emerging evidence from ongoing clinical trials highlights their beneficial effects on a wide range of kidney disorders.

Published
2021
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15. WCN24-2099 BASELINE CHARACTERISTICS OF THE ALIGN TRIAL: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF ATRASENTAN IN PATIENTS WITH IGAN

Author

Heerspink, Hiddo J.L., primary, Jardine, Meg, additional, Kohan, Donald E., additional, Lafayette, Richard A., additional, Levin, Adeera, additional, Liew, Adrian, additional, Zhang, Hong, additional, Gray, Todd, additional, Sheth, Khushboo, additional, Camargo, Marianne, additional, Renfurm, Ronny, additional, King, Andrew, additional, and Barratt, Jonathan, additional

Published
2024
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17. Effects of Sevelamer Carbonate in Patients With CKD and Proteinuria: The ANSWER Randomized Trial

Author

Perico, N., Ruggenenti, P., Remuzzi, G., Ruggiero, B., Trillini, M., Aparicio, C., Tartaglione, L., Rotondi, S., Prandini, S., Lecchi, V., Cugini, D., Gherardi, G., Zoccali, C., Mallamaci, F., Parlongo, G., Panuccio, V., Caridi, G., Tripepi, R., Rubis, N., Diadei, O., Villa, D., Carminati, S., Martinetti, D., Giuliano, G.A., Perna, A., Peraro, F., Celeste, A., Gaspari, F., Carrara, F., Ferrari, S., Stucchi, N., Cannata, A., Mazzaferro, S., Fassino, V., Boccardo, P., Peracchi, S., Ruggiero, Barbara, Trillini, Matias, Tartaglione, Lida, Rotondi, Silverio, Perticucci, Elena, Tripepi, Rocco, Aparicio, Carolina, Lecchi, Veruska, Perna, Annalisa, Peraro, Francesco, Villa, Davide, Ferrari, Silvia, Cannata, Antonio, Mazzaferro, Sandro, Mallamaci, Francesca, Zoccali, Carmine, Bellasi, Antonio, Cozzolino, Mario, Remuzzi, Giuseppe, Ruggenenti, Piero, and Kohan, Donald E.

Published
2019
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18. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Elbert, Alicia, Vallejos, Augusto, Alvarisqueta, Andres, Maffei, Laura, Juncos, Luis, de Arteaga, Javier, Greloni, Gustavo, Farias, Eduardo, Zucchini, Alfredo, Vogel, Daniel, Cusumano, Ana, Santos, Juan, Fraenkel, Margaret, Gallagher, Martin, Davis, Tim, Acharya, Shamasunder, Cooke, Duncan, Suranyi, Michael, Roger, Simon, Toussaint, Nigel, Pollock, Carol, Chan, Doris, Stranks, Stephen, MacIsaac, Richard, Endre, Zoltan, Schmidt, Alice, Prager, Rudolf, Mayer, Gert, Warling, Xavier, Jadoul, Michel, Hougardy, Jean, Vercammen, Chris, Van Vlem, Bruno, Gillard, Pieter, Costa e Forti, Adriana, Borges, Joao Lindolfo, Santos Canani, Luis, Eliaschewitz, Freddy, Leite, Silmara, Fraige Filho, Fadlo, Paschoalin, Raphael, Moura Neto, Jose Andrade, Deboni, Luciane, de Lourdes Noronha, Irene, Cercato, Cintia, Prompt, Carlos Alberto, Zanella, Maria, Rassi, Nelson, D'Avila, Domingos, Milagres, Rosangela, Felicio, Joao, Pecoits Filho, Roberto, Riella, Miguel Carlos, Salles, Joao, Keitel, Elizete, Draibe, Sergio, Amodeo, Celso, Youmbissi, Joseph, Roy, Louise, Cournoyer, Serge, Jolly, Shivinder, Pichette, Vincent, Nesrallah, Gihad, Bajaj, Harpreet Singh, Khandwala, Hasnain, Aronson, Ronnie, Goluch, Richard, Tam, Paul, Rabbat, Christian, Tobe, Sheldon, Bailey, Gordon, Chow, Stephen, Castillo, Alvaro, Danin Vargas, Alfredo, Gonzalez, Fernando, Munoz, Rodrigo, Gutierrez, Vicente, Godoy, Gonzalo, Zhao, Hongwen, Liu, Zhangsuo, Zhao, Minghui, Guo, Xiaohui, Su, Benli, Fu, Shuxia, Xu, Yan, Yang, Jinkui, Shi, Bingyin, Xiao, Guanqing, Shi, Wei, Hao, Chuanming, Xing, Changying, Hou, Fanfan, Luo, Qun, Li, Yuxiu, Ji, Linong, Zuo, Li, Wang, Song, Ni, Zhaohui, Ding, Guohua, Chen, Nan, Zhao, Jiajun, Jia, Weiping, Yu, Shengqiang, Weng, Jian, Xu, Gang, Fu, Ping, Sun, Shiren, Liu, Bicheng, Ding, Xiaoqiang, Rychlik, Ivan, Oplustilova, Alexandra, Bartaskova, Dagmar, Honova, Vaclava, Chmelickova, Hana, Petr, Martin, Bucek, Petr, Tesar, Vladimir, Zahumensky, Emil, Povlsen, Johan, Egstrup, Kenneth, Oczachowska-Kulik, Anna, Rossing, Peter, Lahtela, Jorma, Strand, Jorma, Kantola, Ilkka, Petit, Catherine, Combe, Christian, Zaoui, Philippe, Esnault, Vincent, Urena Torres, Pablo, Halimi, Jean-Michel, Dussol, Bertrand, Bieler, Tasso, Budde, Klemens, Dellanna, Frank, Segiet, Thomas, Kosch, Christine, Schmidt-Guertler, Hans, Schenkenberger, Isabelle, Vielhauer, Volker, Pistrosch, Frank, Alscher, Mark, Hasslacher, Christoph, Hugo, Christian, Muehlfeld, Anja, Wanner, Christoph, Passadakis, Ploumis, Apostolou, Theofanis, Tentolouris, Nikolaos, Stefanidis, Ioannis, Mavromatidis, Konstantinos, Liakopoulos, Vasilios, Goumenos, Dimitrios, Siamopoulos, Konstantinos, Yeung, Vincent, Ozaki, Risa, Fung, Samuel, Tan, Kathryn, Tang, Sydney, Lui, Sing Leung, Cheung, Siu Fai, Sreenan, Seamus, Eustace, Joseph, O'Shea, Donal, Lavin, Peter, Stack, Austin, Yagil, Yoram, Wainstein, Julio, Knobler, Hilla, Cohen, Josef, Kenis, Irina, Daoud, Deeb, Bar-Dayan, Yosefa, Frajewicki, Victor, Adawi, Faiad, Gesualdo, Loreto, Santoro, Domenico, Marino, Francesco, Galfre, Andrea, Brunati, Chiara, Ruggenenti, Piero, Rombola, Giuseppe, Pugliese, Giuseppe, Ravera, Maura, Malberti, Fabio, Pontoriero, Giuseppe, Rampino, Teresa, De Cosmo, Salvatore, Esposito, Ciro, Nappi, Felice, Abaterusso, Cataldo, Conte, Giuseppe, Panichi, Vincenzo, Lauro, Davide, Capasso, Giovambattista, Russo, Domenico, Anzai, Jiichi, Naka, Motoji, Ato, Keita, Tsujimoto, Tetsuro, Nimura, Toshinori, Nakashima, Eitaro, Takeda, Tetsuro, Fujii, Shinya, Kobayashi, Kunihisa, Iwaoka, Hideaki, Nagayama, Koji, Harada, Hiroyuki, Maeda, Hajime, Kishimoto, Rui, Iitsuka, Tadashi, Itabashi, Naoki, Furuya, Ryuichi, Maeda, Yoshitaka, Yamada, Daishiro, Sasaki, Nobuhiro, Sasaki, Hiromitsu, Ueda, Shinichiro, Kashihara, Naoki, Watanabe, Shuichi, Nakamura, Takehiro, Kanai, Hidetoshi, Makita, Yuichiro, Ono, Keiko, Iehara, Noriyuki, Goto, Daisuke, Kosuge, Keiichiro, Tsuchida, Kenichi, Sato, Toshiaki, Sekikawa, Takashi, Okamoto, Hideki, Tanaka, Tsuyoshi, Ikeda, Naoko, Tadika, Takenobu, Mukasa, Koji, Osonoi, Takeshi, Hirano, Fuminori, Nishimura, Motonobu, Yambe, Yuko, Tanaka, Yukio, Ujihara, Makoto, Sakai, Takashi, Imura, Mitsuo, Umayahara, Yutaka, Makino, Shinya, Nakazawa, Jun, Yamaguchi, Yukinari, Kashine, Susumu, Miyaoka, Hiroaki, Suzuki, Katsunori, Inoue, Toshihiko, Nagai, Sou, Sato, Nobuyuki, Yamamoto, Masahiro, Taya, Noriyasu, Fujita, Akira, Matsutani, Akira, Shibagaki, Yugo, Sato, Yuichi, Yamauchi, Akira, Tsutsui, Masahiro, Ishiko, Tamayo, Kaneko, Shizuka, Azuma, Nobuyuki, Matsuda, Hirofumi, Hashiguchi, Yasuhiro, Onishi, Yukiko, Tokui, Mikiya, Matsuhisa, Munehide, Kiyosue, Arihiro, Shinoda, Junji, Ishikawa, Kazuo, Ahmad, Ghazali, Vijayasingham, Shalini, Aziz, Nor Azizah, Hussein, Zanariah, Fung, Yin Khet, Hassan, Wan Hasnul Halimi Wan, Wong, Hin Seng, Goh, Bak Leong, Ali, Norhaliza Mohd, Merican, Nor Shaffinaz Yusuf Azmi, Vaithilingam, Indralingam, Nik Ahmad, Nik Nur Fatnoon, Adam, Noor, Sukor, Norlela, Vengadasalam, V Paranthaman P, Abdul Kadir, Khalid, Mohamed, Mafauzy, Renoirte Lopez, Karina, Leguizamo-Dimas, Aniceto, Chew Wong, Alfredo, Chevaile-Ramos, Jose, Gonzalez Gonzalez, Jose, Rico Hernandez, Raul, Nino-Cruz, Jose, Sauque Reyna, Leobardo, Gonzalez-Galvez, Guillermo, Madero Rovalo, Magdalena, Bochicchio-Ricardelli, Tomasso, Aldrete, Jorge, Carranza-Madrigal, Jaime, Vogt, Liffert, Smak Gregoor, Peter, Barendregt, JNM, Luik, Peter, Gansevoort, Ronald, Laverman, Gozewijn, Pilmore, Helen, Lunt, Helen, Baker, John, Miller, Steven, Rabindranath, Kannaiyan, Zapata-Rincon, Luis, Vargas-Gonzales, Rolando, Calderon Ticona, Jorge, Dextre Espinoza, Augusto, Burga Nunez, Jose, Zea-Nunez, Carlos Antonio, Herrada Orue, Benjamin, Medina-Santander, Boris, Delgado-Butron, Cesar, Farfan-Aspilcueta, Julio, Mazur, Stanislaw, Necki, Miroslaw, Wruk, Michal, Klodawska, Katarzyna, Popenda, Grazyna, Skokowska, Ewa, Arciszewska, Malgorzata, Wiecek, Andrzej, Ciechanowski, Kazimierz, Nowicki, Michal, Birne, Rita, Cabrita, Antonio, Ramos, Aura, Antunes Ferreira, Manuel Anibal, Matta Fontanet, Evelyn, Alcantara-Gonzalez, Altagracia Aurora, Comulada-Rivera, Angel, Galindo Ramos, Eugenia, Cangiano, Jose, Quesada-Suarez, Luis, Calderon Ortiz, Ricardo, Vazquez-Tanus, Jose, Burgos-Calderon, Rafael, Rosado, Carlos, Hancu, Nicolae, Pintilei, Ella, Mistodie, Cristina, Bako, Gabriel, Ionutiu, Lavinia, Petrica, Ligia, Timar, Romulus, Tuta, Liliana, Duma, Livia, Tutescu, Adriana, Ivanova, Svetlana, Essaian, Ashot, Zrazhevskiy, Konstantin, Tomilina, Natalia, Smolyarchuk, Elena, Kuzin, Anatoly, Lantseva, Olga, Karpova, Irina, Shamkhalova, Minara, Liberanskaya, Natalia, Yavdosyuk, Andrey, Shvarts, Yuri, Bardymova, Tatiana, Blagoveshchenskaya, Olga, Solovev, Oleg, Rechkova, Elena, Pikalova, Natalia, Pavlova, Maria, Kolmakova, Elena, Sayfutdinov, Rustam, Villevalde, Svetlana, Koziolova, Natalya, Martynenko, Vladimir, Marasaev, Vyacheslav, Maksudova, Adelya, Sigitova, Olga, Mordovin, Viktor, Klimontov, Vadim, Samoylova, Yulia, Karonova, Tatiana, Yeoh, Lee Ying, Teo, Boon Wee, Foo, Marjorie Wai Yin, Liew, Adrian, Tkac, Ivan, Oroszova, Aniko, Fekete, Jozef, Rosenberger, Jaroslav, Obetkova, Ida, Fulopova, Alla, Kolesarova, Eva, Raslova, Katarina, Smolko, Peter, Oksa, Adrian, Distiller, Larry, Trokis, Julien, Adams, Luthando, Makan, Hemant, Ramlachan, Padaruth, Mitha, Essack, Coetzee, Kathleen, Punt, Zelda, Bhorat, Qasim, Naiker, Puvenesvari, Ellis, Graham, Van Zyl, Louis, Lee, Kwan Woo, Kim, Min Seon, Yoo, Soon-Jib, Yoon, Kun Ho, Cho, Yong-Wook, Park, Tae-Sun, Kim, Sang Yong, Choi, Moon-Gi, Oh, Tae Keun, Lee, Kang-Wook, Shon, Ho Sang, Suh, Sung Hwan, Kim, Byung-Joon, Doo-Man, Kim, Yi, Joo Hark, Lee, Sang Ah, Cho, Ho Chan, Kim, Sin-Gon, Cha, Dae-Ryong, Seo, Ji A, Choi, Kyung Mook, Woo, Jeong-Taek, Ahn, Kyu Jeung, Lee, Jae Hyuk, Kim, In-Joo, Lee, Moon-Kyu, Jang, Hak Chul, Park, Kyong-Soo, Kim, Beom Seok, Mok, Ji Oh, Shin, Mijung, Yoon, Sun Ae, Nam-Goong, Il-Seong, Chung, Choon Hee, Yu, Tae Yang, Lee, Hyoung Woo, Soto Gonzalez, Alfonso, Almirall, Jaume, Egido, Jesus, Calero Gonzalez, Francesca, Fernandez Fresnedo, Gema, Valera Cortes, Ildefonso, Praga Terente, Manuel, Garcia Mendez, Isabel, Navarro Gonzalez, Juan, Herrero Calvo, Jose, Cigarran Guldris, Secundino, Prieto Velasco, Mario, Minguela Pesquera, Jose Ignacio, Galan, Antonio, Pascual, Julio, Marques Vidas, Maria, Martins Munoz, Judith, Rodriguez-Perez, Jose, Castro-Alonso, Cristina, Bonet Sol, Josep, Seron, Daniel, Fernandez Giraldez, Elvira, Arrieta Lezama, Javier, Montero, Nuria, Hernandez-Jaras, Julio, Santamaria Olmo, Rafael, Molas Coten, Jose Ramon, Hellberg, Olof, Fellstrom, Bengt, Bock, Andreas, Pei, Dee, Lin, Ching-Ling, Tien, Kai-Jen, Chen, Ching-Chu, Huang, Chien-Ning, Jiang, Ju-Ying, Wu, Du-An, Chu, Chih-Hsun, Tseng, Shih-Ting, Chen, Jung-Fu, Bau, Cho-Tsan, Sheu, Wayne, Wu, Mai-Szu, Sari, Ramazan, Sezer, Siren, Yildiz, Alaattin, Satman, Ilhan, Kalender, Betul, Mankovskyy, Borys, Fushtey, Ivan, Stanislavchuk, Mykola, Kolenyk, Mykola, Dudar, Iryna, Zolotaikina, Viktoriia, Abrahamovych, Orest, Kostynenko, Tetyana, Petrosyan, Olena, Kuskalo, Petro, Galushchak, Olga, Legun, Oleg, Topchii, Ivan, Martynyuk, Liliya, Stryzhak, Vasyl, Panina, Svitlana, Tkach, Sergii, Korpachev, Vadym, Maxwell, Peter, Gnudi, Luigi, Kon, Sui Phin, Tindall, Hilary, Kalra, Phillip, Mark, Patrick, Patel, Dipesh, El-Shahawy, Mohamed, Bai, Liqun, Nica, Romanita, Lien, Yeong-Hau, Menefee, Judson, Busch, Robert, Miller, Alan, Ahmed, Azazuddin, Arif, Ahmed, Lee, Joseph, Desai, Sachin, Bansal, Shweta, Bentsianov, Marie, Belledonne, Mario, Jere, Charles, Gaona, Raul, Greenwood, Gregory, Brusco, Osvaldo, Boiskin, Mark, Belo, Diogo, Minasian, Raffi, Atray, Naveen, Lawrence, Mary, Taliercio, John, Pergola, Pablo, Scott, David, Alvarez, German, Marder, Bradley, Powell, Thomas, Bakdash, Wa'el, Stoica, George, McFadden, Christopher, Rendell, Marc, Wise, Jonathan, Jones, Audrey, Jardula, Michael, Madu, Ivy-Joan, Varghese, Freemu, Tulloch, Brian, Ahmed, Ziauddin, Hames, Melanie, Nazeer, Imran, Shahid, Newman, John, Rekha, Montero, Manuel, Fitz-Patrick, David, Phillips, Lawrence, Guasch, Antonio, Christofides, Elena, Gundroo, Aijaz, Amin, Mohammad, Bowman-Stroud, Cynthia, Link, Michael, Mulloy, Laura, Nammour, Michael, Lalwani, Tarik, Hanson, Lenita, Whaley-Connell, Adam, Herman, Lee, Chatha, Rupi, Osama, Sayed, Liss, Kenneth, Kayali, Zeid, Bhargava, Anuj, Israel, Ezra, Peguero-Rivera, Alfredo, Fang, Michael, Slover, Judith, Barengolts, Elena, Flores, Jose, Muoneke, Rosemary, Savin, Virginia, Awua-Larbi, Stella, Levine, Andrew, Newman, George, Golestaneh, Laden, Bohm, Guillermo, Reisin, Efrain, Cruz, Lucita, Weiss, Robert, Zieve, Franklin, Horwitz, Edward, Chuang, Peale, Mersey, James, Manley, John, Graf, Ronald, Bedros, Fadi, Joshi, Sudhir, Frias, Juan, Assefi, Ali, O'Shaughnessy, Andrew, Brantley, Roman, Minga, Todd, Tietjen, David, Kantor, Samuel, Jamal, Aamir, Guadiz, Ramon, Hershon, Kenneth, Bressler, Peter, Kopyt, Nelson, Cathcart, Harold, Bloom, Scott, Reichel, Ronald, Nakhle, Samer, Dulude, Emily, Tarkan, Joshua, Baker, Penelope, Zeig, Steven, Moya Hechevarria, Jaynier, Ropero-Cartier, Armando, De la Calle, Gilda, Doshi, Ankur, Saba, Fadi, Sligh, Teresa, Shaw, Sylvia, Kumar, Jayant, Szerlip, Harold, Bayliss, George, Perlman, Alan, Sakhrani, Lakhi, Gouge, Steven, Argoud, Georges, Acosta, Idalia, Elder, John, Joshi, Sucharit, Sensenbrenner, John, Vicks, Steven, Mangoo-Karim, Roberto, Galphin, Claude, Leon-Forero, Carlos, Gilbert, John, Brown, Eric, Ijaz, Adeel, Butt, Salman, Markell, Mariana, Arauz-Pacheco, Carlos, Sloan, Lance, Alvarado, Odilon, Jabbour, Serge, Simon, Eric, Rastogi, Anjay, James, Sam, Bakris, George, Hall, Karen, Melish, John, Dixon, Brad, Adolphe, Allen, Kovesdy, Csaba, Beddhu, Srinivasan, Solomon, Richard, Fernando, Ronald, Levin, Ellis, Thakar, Charuhas, Robey, Brooks, Goldfarb, David, Fried, Linda, Maddukuri, Geetha, Thomson, Stephen, Annand, Andrew, Kronfli, Saeed, Kalirao, Paramjit, Schmidt, Rebecca, Dahl, Neera, Blumenthal, Samuel, Weinstein, Debra, Ostergaard, Ove, Weinstein, Talia, Ono, Yasuhiro, Yalcin, Murat, Karim, Shahana, Heerspink, Hiddo J L, Parving, Hans-Henrik, Andress, Dennis L, Correa-Rotter, Ricardo, Hou, Fan-Fan, Kitzman, Dalane W, Kohan, Donald, Makino, Hirofumi, McMurray, John J V, Melnick, Joel Z, Miller, Michael G, Pergola, Pablo E, Perkovic, Vlado, Yi, Tingting, Wigderson, Melissa, and de Zeeuw, Dick

Published
2019
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20. Collecting Duct Principal Cell Transport Processes and Their Regulation

Author

Pearce, David, Soundararajan, Rama, Trimpert, Christiane, Kashlan, Ossama B, Deen, Peter MT, and Kohan, Donald E

Subjects
Kidney Disease, 1.1 Normal biological development and functioning, Underpinning research, Animals, Aquaporin 2, Body Water, Epithelial Cells, Epithelial Sodium Channels, Humans, Ion Transport, Kidney Tubules, Collecting, Potassium, Potassium Channels, Inwardly Rectifying, Signal Transduction, Sodium, Sodium-Potassium-Exchanging ATPase, Water-Electrolyte Balance, renal physiology, collecting duct, principal cell, epithelial cell, Clinical Sciences, Urology & Nephrology
Abstract

The principal cell of the kidney collecting duct is one of the most highly regulated epithelial cell types in vertebrates. The effects of hormonal, autocrine, and paracrine factors to regulate principal cell transport processes are central to the maintenance of fluid and electrolyte balance in the face of wide variations in food and water intake. In marked contrast with the epithelial cells lining the proximal tubule, the collecting duct is electrically tight, and ion and osmotic gradients can be very high. The central role of principal cells in salt and water transport is reflected by their defining transporters-the epithelial Na(+) channel (ENaC), the renal outer medullary K(+) channel, and the aquaporin 2 (AQP2) water channel. The coordinated regulation of ENaC by aldosterone, and AQP2 by arginine vasopressin (AVP) in principal cells is essential for the control of plasma Na(+) and K(+) concentrations, extracellular fluid volume, and BP. In addition to these essential hormones, additional neuronal, physical, and chemical factors influence Na(+), K(+), and water homeostasis. Notably, a variety of secreted paracrine and autocrine agents such as bradykinin, ATP, endothelin, nitric oxide, and prostaglandin E2 counterbalance and limit the natriferic effects of aldosterone and the water-retaining effects of AVP. Considerable recent progress has improved our understanding of the transporters, receptors, second messengers, and signaling events that mediate principal cell responses to changing environments in health and disease. This review primarily addresses the structure and function of the key transporters and the complex interplay of regulatory factors that modulate principal cell ion and water transport.

Published
2015

21. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

Author

Rovin, Brad H, primary, Barratt, Jonathan, additional, Heerspink, Hiddo J L, additional, Alpers, Charles E, additional, Bieler, Stewart, additional, Chae, Dong-Wan, additional, Diva, Ulysses A, additional, Floege, Jürgen, additional, Gesualdo, Loreto, additional, Inrig, Jula K, additional, Kohan, Donald E, additional, Komers, Radko, additional, Kooienga, Laura Ann, additional, Lafayette, Richard, additional, Maes, Bart, additional, Małecki, Robert, additional, Mercer, Alex, additional, Noronha, Irene L, additional, Oh, Se Won, additional, Peh, Chen Au, additional, Praga, Manuel, additional, Preciado, Priscila, additional, Radhakrishnan, Jai, additional, Rheault, Michelle N, additional, Rote, William E, additional, Tang, Sydney C W, additional, Tesar, Vladimir, additional, Trachtman, Howard, additional, Trimarchi, Hernán, additional, Tumlin, James A, additional, Wong, Muh Geot, additional, Perkovic, Vlado, additional, Abbasciano, Isabella, additional, Abrantes, Catarina, additional, Accarino, Simone, additional, Adler, Sharon, additional, Adoberg, Annika, additional, Afsari, Rouzbeh, additional, Ahmad, Syeda, additional, Ahmed, Jafar, additional, Ahn, Wooin, additional, Ajayi, Bamidele, additional, Aksamit, Dariusz, additional, Al Chalabi, Saif, additional, Alamartine, Eric, additional, Alchi, Bassam, additional, Ali, Mohammad, additional, Aliotta, Roberta, additional, Almaani, Salem, additional, Almeida, Catarina, additional, Almeida, Edgar, additional, Alvarez, Francisco de la Prada, additional, Alves, Patricia, additional, Annese, Francesca, additional, Appel, Gerald, additional, Arduan, Alberto Ortiz, additional, Arena, Maria, additional, Arevalo, Marta Calvo, additional, Arfaania, Dariush, additional, Arias, Carlos, additional, Aristoy, Emma Calatayud, additional, Asakiene, Egle, additional, Ashley, Sarah, additional, Assefi, Ali, additional, Atenza, Alba, additional, Auerbach, Asta, additional, Augustyniak-Bartosik, Hanna, additional, Avella, Monroy, additional, Ayling-Smith, Jonathan, additional, Ayoub, Isabelle, additional, Ayvazyan, Christine, additional, Baccaro, Rocco, additional, Bailey, Asha, additional, Baker, Bruce, additional, Balamuthusamy, Saravanan, additional, Ballarin, Jose, additional, Barata, Rui, additional, Barbic, Jerko, additional, Barisic, Dunja, additional, Barreto, Jose Carlos de Jesus, additional, Barrios, Clara, additional, Belingheri, Mirco, additional, Benesova, Anna, additional, Bernabeu, Ana Avila, additional, Bernhardt, Wanja, additional, Bhadra, Shamik, additional, Biancone, Luigi, additional, Blanchard, Anne, additional, Boaglio, Elena, additional, Bolignano, Davide, additional, Bomback, Andrew, additional, Bonilla, Gustavo Andres Useche, additional, Bordoli, Monica, additional, Bose, Bhadran, additional, Boudville, Neil, additional, Brandon, Donald, additional, Brown, Karen, additional, Broyet, Christian, additional, Bucknall, Thomas, additional, Buffet, Alexandre, additional, Bumblyte', Inga Arune, additional, Burdese, Manuel, additional, Burgos, Natalia Allende, additional, Burguet, Laure, additional, Burtey, Stephane, additional, Busch, Martin, additional, Cakiroglu, Figen, additional, Campbell, Victoria, additional, Canetta, Pietro, additional, Capaccio, Flavia, additional, Carbonell, Juan, additional, Cardoso, Filipa, additional, Carro, Clara Garcia, additional, Carroll, Robert, additional, Carron, Pierre-Louis, additional, Carullo, Nazareno, additional, Cassia, Matthias, additional, Caster, Dawn, additional, Castillo, Belen Vizcaino, additional, Catucci, Davide, additional, Cavalli, Andrea, additional, Chakera, Aron, additional, Chan, Doris, additional, Chan, Gary Chi Wang, additional, Chan, Anthony Ting Pong, additional, Chan, Lai Wan, additional, Chang, Jae Hyun, additional, Chang, Ming-Shan, additional, Chapman, Fiona, additional, Charytan, Chaim, additional, Chaudhry, Asghar, additional, Cheetham, Melissa, additional, Chen, Cheng-Hsu, additional, Chen, Hsin-Yu, additional, Chen, Chien-Liang, additional, Chen, Hung-Yuan, additional, Chen, Hung-Chun, additional, Chenine, Leila, additional, Cheung, Siu Fai, additional, Cheung, Chee Kay, additional, Chiche-Jourde, Noemie, additional, Chiu, Hsien-Fu, additional, Chiu, Yen-Ling, additional, Chiu, Yi-Wen, additional, Chiu, Ian, additional, Choi, Hoon Young, additional, Chou, Kang-Ju, additional, Chowdhury, Paramit, additional, Chowdhury, Pradip, additional, Chrysochou, Constantina, additional, Chukwu, Chukwuma, additional, Chun, Ka Yeong, additional, Chung, Wookyung, additional, Cieniawski, Dominik, additional, Claisse, Guillaume, additional, Clayton, Philip, additional, Cleary, Catalina Martín, additional, Clement, Nisha, additional, Coates, Toby, additional, Cogno, Chiara, additional, Colla, Loredana, additional, Collins, Michael, additional, Colucci, Marco, additional, Combe, Christian, additional, Comi, Nicolino, additional, Comunale, Roderick, additional, Contreras, Gabriel, additional, Cooper, Bruce, additional, Coppock, Gaia, additional, Costa, Ana Cortesão, additional, Costanzi, Stefano, additional, Cozzolino, Mario, additional, Crail, Susan, additional, Cunha, Liliana, additional, Curry, Elizabeth, additional, Dai, Tiane, additional, Daina, Erica, additional, Daneshvari, Sam, additional, Dasgupta, Indranil, additional, DaSilva, Louise, additional, Davidson, Robert, additional, De Bhailis, Aine Maire, additional, de Précigout, Valérie, additional, Decupere, Marc, additional, Delmas, Yahsou, additional, Deodato, Francesca, additional, Dhaun, Neeraj, additional, Dhaygude, Ajay, additional, Dhelaria, Ranjit, additional, Di Maio, Federica, additional, Diezhandino, Maria Angeles Goicoechea, additional, Dika, Zivka, additional, Dinic, Miriana, additional, Dittmer, Ian, additional, Dobre, Mirela, additional, Doctor, Gabriel, additional, Donati, Gabriele, additional, Doubel, Peter, additional, Douthit, Nicole, additional, Draganova, Diliana, additional, Drexler, Yelena, additional, Drinkovic, Martin, additional, Drinovska, Klara, additional, Dudreuilh, Caroline, additional, Dumond, Clement, additional, Durlen, Ivan, additional, Dussol, Bertrand, additional, Encarnacion, Montserrat Diaz, additional, Endre, Zoltan, additional, Enrique, Jorge, additional, Eqbal, Yusuf, additional, Erlich, Jonathan, additional, Esposito, Vittoria, additional, Esposito, Ciro, additional, Fakih, Faisal, additional, Fang, Hua-Chang, additional, Farinha, Ana, additional, Fearday, Aaron, additional, Felgueiras, Joana de Sousa Soares, additional, Felicjanczuk, Elzbieta, additional, Fernandes, João Carlos, additional, Fernandes, Sara, additional, Fernandes, Adriana, additional, Fernandez, Jose Luño, additional, Fernandez, Victor, additional, Fernando, Mangalee, additional, Figueiredo, Ana Carolina, additional, Firre, Eric, additional, Flossmann, Oliver, additional, Floyd, Lauren, additional, Fonseca, Nuno, additional, Fonseca, Jose Nuno de Almeida Agapito, additional, Foote, Celine, additional, Forbes, Suzanne, additional, Forcen, Angel, additional, Fornoni, Alessia, additional, Fouassier, David, additional, Fraser, Ian, additional, Fung, Ka Shun Samuel, additional, Furlano, Monica, additional, Furtado, Teresa, additional, Gadh, Rajdeep, additional, Gaisset, Roxane, additional, Gallagher, Martin, additional, Gameiro, Joana, additional, Gangadharan, Muralikrishna, additional, Garcia, Fabiola Alonso, additional, Garcia, Olga Gracia, additional, Garg, Gunjan, additional, Garrouste, Cyril, additional, Gautam, Archana, additional, Geara, Abdallah, additional, Geddes, Colin, additional, Gellineo, Lana, additional, Germain, Michael, additional, Ghalli, Farid, additional, Giaroni, Francesco, additional, Giles, Harold, additional, Gillies, Alastair, additional, Gimeno, Ana Vilar, additional, Girardet, Annette, additional, Glaze, Jeffrey, additional, Goh, Tze, additional, Gois, Mario, additional, Goldsmith, Christopher, additional, Goma, Elena, additional, Gomes, Ana Marta, additional, Goncalves, Luis Pedro Falcao, additional, Goncalves, Sara, additional, Gontarek-Kacprzak, Julita, additional, Gonzalez, Carlos, additional, Gopu, Arun, additional, Gowda, Nayan, additional, Gray, Nicholas, additional, Greco, Barbara, additional, Green, Heather, additional, Greze, Clarisse, additional, Griffin, Sian, additional, Guldris, Secundino Cigarran, additional, Guzman, Ursula Verdalles, additional, Ha, Jeffrey Tsun Kit, additional, Hall, Amanda, additional, Hamilton, Patrick, additional, Han, Seung Hyeok, additional, Haws, Robert, additional, Hayat, Ashik, additional, Heath, Lauren, additional, Heinrichs, Sven, additional, Henderson, Andrew, additional, Henderson, Amy, additional, Hendren, Elizabeth, additional, Heng, Anne-Elisabeth, additional, Heres, Salia Virxinia Pol, additional, Herfurth, Johann Konstantin, additional, Herrero, Evangelina Merida, additional, Ho, Tzung-Yo, additional, Hogan, Jonathan, additional, Hohenstein, Bernd, additional, Hollett, 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Praveena, additional, Kadakia, Jigar, additional, Kamal, Fahameedah, additional, Kanigicherla, Durga, additional, Karanovic, Sandra, additional, Karras, Alexandre, additional, Kasimatis, Theodoros, additional, Kassem, Mohamad, additional, Kattamanchi, Siddhartha, additional, Keller, Christopher, additional, Kentric, Dubravka Trajbar, additional, Kettner, Christiane, additional, Khalil, Kassem, additional, Kim, Dana, additional, Kim, Se Joong, additional, Kim, Yeong Hoon, additional, Kim, Yunmi, additional, Kim, Hyung Wook, additional, Kim, Sunggyun, additional, Kim, Jwa-Kyung, additional, Kim, Aejin, additional, Kim, Myung-Gyu, additional, Kimber, Cassandra, additional, Klamm, Kathryn, additional, Koch, Annegret, additional, Koester, Eric, additional, Kolvald, Kulli, additional, Kon, Sui, additional, Kotwal, Sradha, additional, Krajewska, Magdalena, additional, Kratka, Karolina, additional, Krishnan, Anoushka, additional, Krishnasamy, Rathika, additional, Krueger, Thilo, additional, Kruljac, Ivan, additional, Kulka, Simone, additional, Kunzendorf, Ulrich, additional, Kuo, Mei-Chuan, additional, Kuo, Hung-Tien, additional, Kuo, Sheng, additional, Kwan, Lorraine Pui Yuen, additional, Kwella, Norbert, additional, Kwella, Bogna, additional, Kyaw, Kay, additional, Labat, Aurore, additional, Lagatta, Mark, additional, Lam, Chi Kwan Darwin, additional, Lambie, Mark, additional, Lanaret, Camille, additional, Latif, Farah, additional, Laute, Margo, additional, Law, Wai Ping, additional, Lawman, Sarah, additional, Lazo, Mercedes Salgueira, additional, Lee, Hajeong, additional, Lee, Moon Hyoung, additional, Lee, Kyu-Beck, additional, Lee, Hyung-seok, additional, Lee, JungEun, additional, Lee, Hyun Hee, additional, Lee, Po-Tsang, additional, Leis, Liisi, additional, Lemahieu, Wim, additional, Leung, Janson, additional, Li, Yan, additional, Lie, Davina Ngoi Wah, additional, Lifland, Howard, additional, Lilienthal, Kadri, additional, Lim, Wai, additional, Limardo, Monica, additional, Livrozet, Marine, additional, Longhi, Selena, additional, Lopes, Daniela, additional, Lopes, Jose Antonio, additional, Lorde, Nathan, additional, Luxton, Grant, additional, Ma, Mingyao, additional, Madhrira, Machaiah, additional, Madonia, Phillip, additional, Mahadevan, Kumaradevan, additional, Mahdi, Amar, additional, Mahdi, Eamon, additional, Maillard, Nicolas, additional, Maixnerova, Dita, additional, Majstorovic Barac, Karolina, additional, Malecki, Robert, additional, Malfait, Thomas, additional, Malvica, Silvia, additional, Mandayam, Sreedhar, additional, Manley, Paul, additional, Mansfield, Nick, additional, Marcantoni, Carmelita, additional, Mariat, Christophe, additional, Marin, Tamara Malek, additional, Marin, Lida Maria Rodas, additional, Mark, Patrick, additional, Marques, Joana, additional, Martinez, Eduardo Gutierrez, additional, Martinez, Stacy, additional, Masset, Catherine, additional, Masson, Ingrid, additional, Mather, Amanda, additional, Maung Myint, Thida Maung, additional, Mayet, Valentin, additional, McCafferty, Kieran, additional, McCarthy, Ellen, additional, McDonald, Stephen, additional, McGreal, Kerri, additional, McMahon, Kellyn, additional, McNally, Andrew, additional, McQuarrie, Emily, additional, Medina, Allyson, additional, Meeus, Gert, additional, Mehta, Kshama, additional, Mendoza, Elder, additional, Menezes, Maria, additional, Meng, Jerry, additional, Messa, Piergiorgio, additional, Messias, Ana, additional, Miarka, Przemyslaw, additional, Miglinas, Marius, additional, Mikacic, Ivana, additional, Mikhail, Ashraf, additional, Milicevic, Martina, additional, Minasian, Raffi, additional, Moeller, Marcus, additional, Mohey, Hesham, additional, Mojarrab, Javad, additional, Mok, Maggie Ming Yee, additional, Moncasi, Eduardo Parra, additional, Moonen, Martial, additional, Morales, Wenceslao Adrian Aguilera, additional, Moreno, Eduardo Verde, additional, Moreno, Antolina, additional, Morris, Adam, additional, Moutzouris, Dimitrios, additional, Moya, Mercedes Gonzalez, additional, Mucha, Simon, additional, Musolino, Michela, additional, Napodano, Pietro, additional, Natario, Ana, additional, Negrea, Lavinia, additional, Nelson, Bradley, additional, Neuen, Brendon, additional, Newsome, Britt, additional, Ng, Kit Chung Jack, additional, Nguyen, Thu, additional, Nguyen, Viet, additional, Nicolo, Clementine, additional, Nitschke, Martin, additional, Noble, Euan, additional, Nolasco, Fernando, additional, O'Lone, Emma, additional, Ochoa, Adriana Sierra, additional, Oh, Kook-Hwan, additional, Oh, SeWon, additional, Okoh, Pedro, additional, Ombelet, Sara, additional, O'Shaughnessy, Michelle, additional, Ou, Shih-Hsiang, additional, Packham, David, additional, Padiyar, Aparna, additional, Pai, Mei-Fen, additional, Pamplona, Irene Agraz, additional, Pan, Szu-Yu, additional, Pandya, Bhavna, additional, Papadia, Federica, additional, Pardinhas, Clara, additional, Parikh, Nishita, additional, Parikh, Samir, additional, Park, Hyeong Cheon, additional, Park, Jung Tak, additional, Parreira, Lucia, additional, Passerini, Patrizia, additional, Patak, Ramachandra, additional, Patecki, Margret, additional, Patel, Rajan, additional, Patel, Jusmin, additional, Patel Suthar, Meera, additional, Patella, Gemma, additional, Patrikyan, Artashes, additional, Pavlovic, Drasko, additional, Paxton, William, additional, Peh, Chen, additional, Peleg, Yonatan, additional, Pelicano, Josep Miquel Blasco, additional, Peng, Yu-Sen, additional, Pereira de Vicente, Manuel, additional, Perez, Jonay Pantoja, additional, Perez, Erika, additional, Perez de Jose, Ana, additional, Pérez Gómez, María Vanessa, additional, Perez Lluna, Leticia, additional, Peri, Usha, additional, Perico, Norberto, additional, Philipponnet, Carole, additional, Phua, Elaine, additional, Piel, Julia, additional, Pillai, Unnikrishnan, additional, Pilmore, Helen, additional, Plavljanic, Djuro, additional, Plaza, Mercedes Velo, additional, 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Rony, Mohammad, additional, Rosenberg, Mai, additional, Roueff, Stephane, additional, Rovin, Brad, additional, Roxburgh, Sarah, additional, Ruiz, Mario, additional, Rusinol, Helena Marco, additional, Rychlik, Ivan, additional, Sá, Helena, additional, Salehi, Tania, additional, Sánchez de la Nieta, Maria Dolores, additional, Sanden, Silja, additional, Santockiene, Lina, additional, Santos, Patricia Valerio, additional, Santos, Iara Da Silva, additional, Sargsyan, Mari, additional, Sarnow, Franziska, additional, Sat, Sebahat, additional, Satora, Ewa, additional, Savuk, Ana, additional, Sayer, Matthew, additional, Schlieper, Georg, additional, Schlosser, Mandy, additional, Schmidt-Guertler, Hans, additional, Schockaert, Olivier, additional, Schulte, Kevin, additional, Schulz, Lisa, additional, Selvaskandan, Haresh, additional, Semple, David, additional, Sen, Shaundeep, additional, Seppet, Elviira, additional, Serrano, Antonio Galan, additional, Serre, Jean-Emmanuel, additional, Sevillano, 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additional, Suyumova, Irina, additional, Szeto, Cheuk Chun, additional, Tamarit, Esther, additional, Tan, Eddie, additional, Tan, May, additional, Tang, Sydney Chi Wai, additional, Tang, Hon, additional, Teixeira, Catarina, additional, Telling, Kadri, additional, Terrades, Natalia Ramos, additional, Tez, Didem, additional, Thervet, Eric, additional, Thibaudin, Damien, additional, Thomas, Mark, additional, Thyagarajan, Nikhil, additional, Tkaczyk, Marcin, additional, Torreggiani, Massimo, additional, Trillini, Matias, additional, Tsai, Shang-Feng, additional, Tsai, Wan-Chuan, additional, Tsai, Jer-Chia, additional, Tseng, Po-Yu, additional, Tumlin, James, additional, Tung, Kuei-Ting, additional, Turnbull, Angus, additional, Udani, Suneel, additional, Uhlinova, Jana, additional, Unt, Kristin, additional, Urciuolo, Federica, additional, Vanacker, An, additional, Vandewiele, Bert, additional, Vaz, Alvaro, additional, Veermae, Kristi, additional, Viaene, Liesbeth, additional, Vickiene, Alvita, additional, Vigano, Sara, additional, Vila, Maria Antonia Munar, additional, Vilayur, Eswari, additional, Villanueva, Caridad Martinez, additional, Villarroya, Cristina Medrano, additional, Villen, Alejandro Soria, additional, Viramontes, Veronica, additional, Vita, Caterina, additional, Vujcic, Dunja, additional, Wahba, Mona, additional, Wan, Susan, additional, Wang, Chih-Hsien, additional, Warling, Xavier, additional, Waters, Gerald, additional, Waugh, Jane, additional, Weiland, Lea, additional, Weiner, Stefan, additional, Weinreich, Thomas, additional, Werth, Stephan Christian, additional, Wickens, Olivia, additional, Wijeratne, Vidu, additional, Wilder, Karen, additional, Willcocks, Lisa, additional, Williams, Allister, additional, Winiarska, Agata, additional, Wirtz, Nikolaus, additional, Wolf, Lothar, additional, Wolf, Gunter, additional, Wong, Yick Hei, additional, Wong, Sze Ho Sunny, additional, Workeneh, Biruh, additional, Wu, Ming-Ju, additional, Wu, Hon-Yen, additional, Wyndham, Roger, additional, Yang, Jihyun, additional, Yang, Ju-Yeh, additional, Yeap, Chii, additional, Yim, Ka Fai, additional, Yong, Kenneth, additional, Yoo, Tae-Hyun, additional, Yoon, Songuk, additional, Yu, Tung-Min, additional, Yue, Tak Tai Andrew, additional, Zakari, Michel, additional, Zakauskiene, Urte, additional, Zaoui, Philippe, additional, Zbrzezniak, Justyna, additional, Zielinska, Dorota, additional, and Zizzi, Carlotta Federica, additional

Published
2023
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24. Endothelin

Author

Davenport, Anthony P., Hyndman, Kelly A., Dhaun, Neeraj, Southan, Christopher, Kohan, Donald E., Pollock, Jennifer S., Pollock, David M., Webb, David J., and Maguire, Janet J.

Published
2016
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29. Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial

Author

Webb, David J., Coll, Blai, Heerspink, Hiddo J. L., Andress, Dennis, Pritchett, Yili, Brennan, John J., Houser, Mark, Correa-Rotter, Ricardo, Kohan, Donald, Makino, Hirofumi, Perkovic, Vlado, Remuzzi, Giuseppe, Tobe, Sheldon W., Toto, Robert, Busch, Robert, Pergola, Pablo, Parving, Hans-Henrik, and de Zeeuw, Dick

Published
2017
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42. Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long‐Term Response to Atrasentan in Patients With Diabetic Kidney Disease

Author

Smeijer, J. David, primary, Koomen, Jeroen V., additional, Kohan, Donald E., additional, McMurray, John J. V., additional, Bakris, George L., additional, Correa‐Rotter, Ricardo, additional, Hou, Fan‐Fan, additional, Kitzman, Dalane W., additional, Makino, Hirofumi, additional, Mayer, Gert, additional, Nowicki, Michal, additional, Perkovic, Vlado, additional, Rossing, Peter, additional, Tobe, Sheldon, additional, Parving, Hans‐Henrik, additional, de Zeeuw, Dick, additional, and Heerspink, Hiddo J. L., additional

Published
2022
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44. Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long-Term Response to Atrasentan in Patients With Diabetic Kidney Disease

Author

Smeijer, J. David, Koomen, Jeroen V., Kohan, Donald E., McMurray, John J.V., Bakris, George L., Correa-Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Makino, Hirofumi, Mayer, Gert, Nowicki, Michal, Perkovic, Vlado, Rossing, Peter, Tobe, Sheldon, Parving, Hans Henrik, de Zeeuw, Dick, Heerspink, Hiddo J.L., Smeijer, J. David, Koomen, Jeroen V., Kohan, Donald E., McMurray, John J.V., Bakris, George L., Correa-Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Makino, Hirofumi, Mayer, Gert, Nowicki, Michal, Perkovic, Vlado, Rossing, Peter, Tobe, Sheldon, Parving, Hans Henrik, de Zeeuw, Dick, and Heerspink, Hiddo J.L.

Abstract

Plasma exposure of the endothelin receptor antagonist atrasentan varies between individuals and is associated with nephroprotective effects and the risk of heart failure. We examined the influence of genetic polymorphisms on atrasentan plasma exposure and pharmacodynamic effects. We performed a substudy of the Study of Diabetic Nephropathy With Atrasentan (SONAR) trial which enrolled adults with type 2 diabetes and chronic kidney disease (estimated glomerular filtration rate: 25–75 mL/min/1.73 m2, and a urine albumin-to-creatinine ratio of 300–5,000 mg/g). Single nucleotide polymorphisms (SNPs) were determined for prespecified membrane transporters, metabolizing enzymes, and the endothelin-1 peptide. The associations among genotype, atrasentan plasma exposure, and the effect of atrasentan on the prespecified kidney and heart failure hospitalization (HHF) outcomes was assessed with Cox proportional hazards regression models. Of 3,668 patients randomized, 2,329 (63.5%) consented to genotype analysis. Two SNPs in the SLCO1B1 gene (rs4149056 and rs2306283), encoding the hepatic organic anion transporter 1B1 (OATP1B1), showed the strongest association with atrasentan plasma exposure. Based on their SLCO1B1 genotype, patients were classified into normal (atrasentan area under the plasma-concentration time curve from zero to infinity (AUC0−inf) 41.3 ng·h/mL) or slow (atrasentan AUC0−inf 49.7 ng·h/mL, P < 0.001) OATP1B1 transporter phenotypes. Among patients with a normal OATP1B1 phenotype, the hazard ratio (HR) with atrasentan for the primary kidney and HHF outcomes were 0.61 (95% confidence interval (CI): 0.45–0.81) and 1.35 (95% CI: 0.84–2.13), respectively. In the slow transporter phenotype, HRs for kidney and HHF outcomes were 1.95 (95% CI: 0.95–4.03, P-interaction normal phenotype = 0.004), and 4.18 (95% CI: 1.37–12.7, P-interaction normal phenotype = 0.060), respectively. OATP1B1 gene polymorphisms are associated with significan

Published
2022

47. Prediction of the effect of atrasentan on renal and heart failure outcomes based on short-term changes in multiple risk markers

Author

Schievink, Bauke, de Zeeuw, Dick, Smink, Paul A, Andress, Dennis, Brennan, John J, Coll, Blai, Correa-Rotter, Ricardo, Hou, Fan Fan, Kohan, Donald, Kitzman, Dalane W, Makino, Hirofumi, Parving, Hans-Henrik, Perkovic, Vlado, Remuzzi, Giuseppe, Tobe, Sheldon, Toto, Robert, Hoekman, Jarno, and Heerspink, Hiddo Lambers J

Published
2016
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