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527 results on '"Koh, Seong-Beom"'

1. Efficacy and safety of safinamide in Parkinson’s disease patients with motor fluctuations without levodopa dosage escalation over 18 weeks: KEEP study

Author

Oh, Eungseok, Cheon, Sang-Myeong, Cho, Jin Whan, Sung, Young Hee, Kim, Joong-Seok, Shin, Hae-Won, Kim, Jong-Min, Park, Mee Young, Kwon, Do-Young, Ma, II, Hyeo, Park, Jeong-Ho, Koh, Seong-Beom, Choi, Seong-Min, Park, Jinse, Lee, Phil Hyu, Ahn, Tae-Beom, Kim, Sang Jin, Lyoo, Chul Hyoung, Lee, Ho-Won, Kim, Jieun, Lee, Yoona, and Baik, Jong Sam

Published
2024
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10. A prospective multi-centre study of susceptibility map-weighted MRI for the diagnosis of neurodegenerative parkinsonism

Author

Sung, Young Hee, Kim, Joong-Seok, Yoo, Sang-Won, Shin, Na-Young, Nam, Yoonho, Ahn, Tae-Beom, Yoo, Dallah, Lee, Kyung Mi, Kim, Hyug-Gi, Koh, Seong-Beom, Kim, Jinhee, Kim, Ilsoo, Kwon, Do-Young, Lee, Younghen, Kim, Chulhan, Chung, Sun Ju, Jo, Sungyang, Lee, Seung Hyun, Kim, Sang Joon, Kim, Minjae, Lyoo, Chul Hyoung, Baek, Min Seok, Kang, Suk Yun, Chang, Suk Ki, Jo, Sang-Won, Lee, Seun Ah, Ma, Hyeo-il, Kim, Young Eun, Kim, Eun Soo, Kim, Yun Joong, Kim, Hyun Sook, Woo, Min-Hee, Choi, Hye Jeong, and Kim, Eung Yeop

Published
2022
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12. Association Between Body Mass Index Changes and All-Cause Mortality in Parkinson's Disease.

Author

Yoon, Seo Yeon, Choi, Ja Young, Nam, Ga Eun, Jung, Jin-Hyung, Han, Kyungdo, Kang, Sung Hoon, Kim, Chi Kyung, Kim, Yong Wook, and Koh, Seong-Beom

Subjects
BODY mass index, MEDICAL screening, WEIGHT loss, PARKINSON'S disease, WEIGHT gain
Abstract

Background: Whether body weight changes are associated with Parkinson's disease (PD) mortality remains uncertain. Objective: To investigate the association between changes in body mass index (BMI) and all-cause mortality in patients with PD. Methods: This nationwide cohort study enrolled 20,703 individuals with new-onset PD (ICD-10 code: G20 and a rare intractable disease registration code: V124) who underwent health screening program by the Korean National Health Insurance Service within two years from pre- and post-PD diagnosis. We identified nine BMI change groups based on three BMI status: underweight (BMI < 18.5 kg/m2), normal or overweight (18.5 kg/m2≤BMI < 25 kg/m2), and obese (BMI≥25 kg/m2). Results: Of 20,703 individuals, 3,789 (18.0%) died during the follow-up period. Excessive weight loss to underweight in the obese group (hazard ratio [HR] = 3.36, 95% CI:1.60–7.08), weight loss in the normal to overweight group (HR = 2.04, 95% CI:1.75–2.39), sustained underweight status (HR = 2.05, 95% CI:1.67–2.52), and weight gain from underweight to normal or overweight (HR = 1.52, 95% CI:1.15–2.02) were associated with increased mortality. Sustained obese status (HR = 0.80, 95% CI:0.74–0.87) and weight gain in the normal to overweight group (HR = 0.82, 95% CI:0.71–0.95) were associated with reduced mortality. Conclusions: We found that BMI change at diagnosis was associated with mortality in patients with PD. Specifically, being underweight either before or after diagnosis as well as experiencing weight loss, were associated with increased mortality. These findings provide valuable insights for weight management planning in PD, highlighting the importance of individualized approach that consider pre-diagnosis BMI. Plain Language Summary: Whether body weight changes are associated with Parkinson's disease (PD) mortality remains uncertain. This study looked at how changes in body weight affect the chances of survival in people who have recently been diagnosed with PD. We followed 20,703 individuals who were newly diagnosed with this condition and checked their weight changes before and after their diagnosis. We found that people with PD who lost a lot of weight to become underweight had a higher risk of dying during our study. Similarly, those who were already underweight and remained so also had a higher mortality risk. On the other hand, people who maintained a weight or gained a small amount of weight after their diagnosis had the lowest risk of dying. Our research found that weight changes at diagnosis were associated with mortality in PD, with underweight or weight loss being linked to increased risk of death. Each person's situation is different, so weight management should be tailored to each individual, considering their weight before they were diagnosed with PD. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Evaluating the validity and reliability of the Korean version of Scales for Outcomes in Parkinson’s Disease–Cognition

Author

Park, Jinse, primary, Oh, Eung Seok, additional, Koh, Seong-Beom, additional, Song, In-Uk, additional, Ahn, Tae-Beom, additional, Kim, Sang Jin, additional, Cheon, Sang-Myung, additional, Kim, Yun Joong, additional, Cho, Jin Whan, additional, Ma, Hyeo-Il, additional, Park, Mee-Young, additional, Baik, Jong Sam, additional, Lee, Phil Hyu, additional, Chung, Sun Ju, additional, Kim, Jong-Min, additional, Kim, Han-Joon, additional, Sung, Young-Hee, additional, Kwon, Do Young, additional, Lee, Jae-Hyeok, additional, Lee, Jee-Young, additional, Kim, Ji Sun, additional, Yun, Ji Young, additional, Kim, Hee Jin, additional, Hong, Jin Young, additional, Kim, Mi-Jung, additional, Youn, Jinyoung, additional, Kim, Ji Seon, additional, Yang, Hui-Jun, additional, Yoon, Won Tae, additional, You, Sooyeoun, additional, Kwon, Kyum-Yil, additional, Lee, Su-Yun, additional, Kim, Younsoo, additional, Kim, Hee-Tae, additional, Kim, Joong-Seok, additional, and Kim, Ji-Young, additional

Published
2024
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24. Caregiver burden of patients with Huntington’s disease in South Korea

Author

Lee, Chan Young, primary, Shin, Chaewon, additional, Hwang, Yun Su, additional, Oh, Eungseok, additional, Kim, Manho, additional, Kim, Hyun Sook, additional, Chung, Sun Ju, additional, Sung, Young Hee, additional, Yoon, Won Tae, additional, Cho, Jin Whan, additional, Lee, Jae-Hyeok, additional, Kim, Han-Joon, additional, Chang, Hee Jin, additional, Jeon, Beomseok, additional, Woo, Kyung Ah, additional, Koh, Seong-Beom, additional, Kwon, Kyum-Yil, additional, Moon, Jangsup, additional, Kim, Young Eun, additional, and Lee, Jee-Young, additional

Published
2023
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28. Validity and Reliability of the Korean-Translated Version of the International Cooperative Ataxia Rating Scale in Cerebellar Ataxia

Author

Park, Jinse, primary, Cho, Jin Whan, additional, Youn, Jinyoung, additional, Oh, Engseok, additional, Jang, Wooyoung, additional, Kim, Joong-Seok, additional, Oh, Yoon-Sang, additional, Hwang, Hyungyoung, additional, Rhu, Chang-Hwan, additional, Ahn, Jin-Young, additional, Lee, Jee-Young, additional, Koh, Seong-Beom, additional, Park, Jae H., additional, and Kim, Hee-Tae, additional

Published
2023
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30. The Four Square Step Test for Assessing Cognitively Demanding Dynamic Balance in Parkinson’s Disease Patients

Author

Kim, Jinhee, Kim, Ilsoo, Kim, Ye Eun, and Koh, Seong-Beom

Subjects
medicine.medical_specialty, Parkinson's disease, Four square step test, Neurosciences. Biological psychiatry. Neuropsychiatry, Physical medicine and rehabilitation, Executive function, Rating scale, medicine, RC346-429, Dynamic balance, Gait, Balance (ability), business.industry, Cognition, Stride length, medicine.disease, Neurology, Parkinson’s disease, Step test, Original Article, Neurology. Diseases of the nervous system, Neurology (clinical), business, RC321-571
Abstract

Objective The Four Square Step Test (FSST) is a tool that assesses dynamic balance during obstacle step-over. To date, few studies have used the FSST to measure balance in patients with Parkinson’s disease (PD). This study aimed to verify that patients with PD, even at the de novo early stage, take more time to perform the FSST and identify which factors, cognitive status or cardinal motor symptoms, are related most to FSST scores.Methods Thirty-five newly diagnosed drug-naïve patients with PD and 17 controls completed the FSST. The Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) stage, spatiotemporal gait parameters, and neuropsychological test battery were also assessed in the PD group.Results Mean FSST performance time was 8.20 ± 1.61 seconds in patients with PD, which was significantly more than the control group (7.13 ± 1.10 seconds, p = 0.018). UPDRS part III total score and H&Y stage were not significantly associated with FSST, but among the UPDRS subscores, only the postural instability/gait disturbance subscore showed a significant association. Regarding the association between FSST and cognition, the Trail Making Test-B and the Color Word Stroop Test showed strongly inverse correlations with FSST (rho = -0.598 and -0.590, respectively). With respect to gait parameters, double support time was significantly associated with FSST score (rho = 0.342, p = 0.044); however, other parameters, including velocity and step length, were not associated with the FSST.Conclusion The FSST can be used in the clinic to assess dynamic balance with cognitive demands even in the early stages of PD.

Published
2021
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36. Movement Disorders Associated With Cerebral Artery Stenosis: A Nationwide Study

Author

Park, Kye Won, primary, Choi, Nari, additional, Oh, Eungseok, additional, Lyoo, Chul Hyoung, additional, Baek, Min Seok, additional, Kim, Han-Joon, additional, Yoo, Dalla, additional, Lee, Jee-Young, additional, Choi, Ji-Hyun, additional, Lee, Jae Hyeok, additional, Koh, Seong-Beom, additional, Sung, Young Hee, additional, Cho, Jin Whan, additional, Yang, Hui-Jun, additional, Park, Jinse, additional, Shin, Hae-Won, additional, Ahn, Tae-Beom, additional, Ryu, Ho-Sung, additional, You, Sooyeoun, additional, Choi, Seong-Min, additional, Kim, Bum Joon, additional, Lee, Seung Hyun, additional, and Chung, Sun Ju, additional

Published
2022
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45. Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer’s Disease Biomarkers

Author

Kang, Sung Hoon, primary, Cho, Hanna, additional, Shin, Jiho, additional, Kim, Hang-Rai, additional, Noh, Young, additional, Kim, Eun-Joo, additional, Lyoo, Chul Hyoung, additional, Jang, Hyemin, additional, Kim, Hee Jin, additional, Koh, Seong-Beom, additional, Na, Duk L., additional, Suh, Mee Kyung, additional, and Seo, Sang Won, additional

Published
2021
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46. Hippocampal volume is related to olfactory impairment in Parkinson's disease.

Author

Roh, Haewon, Kang, June, Koh, Seong‐Beom, Kim, Jong Hyun, and Koh, Seong-Beom

Subjects
PARKINSON'S disease, SMELL, HIPPOCAMPUS (Brain), COGNITION disorders, OLFACTOMETRY
Abstract

Background and Purpose: Recent evidence has suggested that hyposmia in patients with Parkinson's disease (PD) may be due to impaired central processing. Furthermore, the hippocampus has been regarded as a critical structure linking olfactory impairment and cognitive impairment in PD patients. This study aimed to identify significant structural alterations of the hippocampus in PD patients with hyposmia, and to determine whether these structural changes are significantly associated with olfactory impairment severity.Methods: Eighteen idiopathic PD patients with hyposmia and 18 age- and sex-matched PD patients without hyposmia were enrolled. Hippocampal volume and its subfields were measured using FreeSurfer software and compared between hyposmic and normosmic PD patients. We also compared hippocampal substructures' volumes and correlated the hippocampal volumes with hyposmia severity.Results: PD patients with hyposmia had significantly smaller hippocampal volumes. Among the three components of the hippocampus, the hippocampal body showed a markedly lower volume, which correlated significantly with the cross-cultural smell identification test score that represents olfactory function status. Hippocampal subfield analysis showed that substructures (subiculum, molecular layer) that constitute the hippocampal body showed the most significant volume difference.Conclusions: We suggest that atrophy of the bilateral hippocampus implies underlying problems in the central olfaction process in PD patients. In particular, the hippocampus might not only play a critical role in olfaction but could also be important for elucidating possible mechanisms of broad nonmotor symptoms in PD patients. [ABSTRACT FROM AUTHOR]

Published
2021
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