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14. Iron-Reduced Graphene Oxide Core–Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light.

Author

Donoso-González, Orlando, Riveros, Ana L., Marco, José F., Venegas-Yazigi, Diego, Paredes-García, Verónica, Olguín, Camila F., Mayorga-Lobos, Cristina, Lobos-González, Lorena, Franco-Campos, Felipe, Wang, Joseph, Kogan, Marcelo J., Bollo, Soledad, Yañez, Claudia, and Báez, Daniela F.

Subjects
MAGNETISM, GRAPHENE oxide, NEAR infrared radiation, PHOTOTHERMAL conversion, PHOTOTHERMAL effect, MICROMOTORS
Abstract

Core–shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to the limited penetration of near-infrared (NIR) light. In this study, we present a novel core–shell micromotor that combines magnetic and photothermal properties. It is synthesized via the template-assisted electrodeposition of iron (Fe) and reduced graphene oxide (rGO) on a microtubular pore-shaped membrane. The resulting Fe-rGO micromotor consists of a core of oval-shaped zero-valent iron nanoparticles with large magnetization. At the same time, the outer layer has a uniform reduced graphene oxide (rGO) topography. Combined, these Fe-rGO core–shell micromotors respond to magnetic forces and near-infrared (NIR) light (1064 nm), achieving a remarkable photothermal conversion efficiency of 78% at a concentration of 434 µg mL−1. They can also carry doxorubicin (DOX) and rapidly release it upon NIR irradiation. Additionally, preliminary results regarding the biocompatibility of these micromotors through in vitro tests on a 3D breast cancer model demonstrate low cytotoxicity and strong accumulation. These promising results suggest that such Fe-rGO core–shell micromotors could hold great potential for combined photothermal therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The cervical and meningeal lymphatic network as a pathway for retrograde nanoparticle transport to the brain

Author

Ramos-Zaldívar, Héctor M., primary, Polakovicova, Iva, additional, Salas-Huenuleo, Edison, additional, Yefi, Claudia P., additional, Silva, David, additional, Jara-Guajardo, Pedro, additional, Oyarzún, Juan Esteban, additional, Neira-Troncoso, Álvaro, additional, Burgos, Patricia V., additional, Cavieres, Viviana A., additional, Arias-Muñoz, Eloisa, additional, Martínez, Carlos, additional, Riveros, Ana L., additional, Corvalán, Alejandro H., additional, Kogan, Marcelo J., additional, and Andia, Marcelo E., additional

Published
2024
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17. Impact of Ligand Exchange on Gold Nanostars’ Reshaping, Stabilization, Photothermal Efficiency, and Cell Viability

Author

Donoso-González, Orlando, primary, Hengsbach, Rebecca, additional, Ohlerth, Thorsten, additional, Noyong, Michael, additional, Sierpe, Rodrigo, additional, Rozas-Castro, Nicolás, additional, Lodeiro, Lucas, additional, Bolaños, Karen, additional, Melo, Francisco, additional, Yutronic, Nicolás, additional, Kogan, Marcelo J., additional, and Simon, Ulrich, additional

Published
2023
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20. β-Cyclodextrin Nanosponges Inclusion Compounds Associated with Silver Nanoparticles to Increase the Antimicrobial Activity of Quercetin

Author

Salazar Sandoval, Sebastián, primary, Bruna, Tamara, additional, Maldonado-Bravo, Francisca, additional, Bolaños, Karen, additional, Adasme-Reyes, Sofía, additional, Riveros, Ana, additional, Caro, Nelson, additional, Yutronic, Nicolás, additional, Silva, Nataly, additional, Kogan, Marcelo J., additional, and Jara, Paul, additional

Published
2023
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21. Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease

Author

Morales-Zavala, Francisco, Arriagada, Hector, Hassan, Natalia, Velasco, Carolina, Riveros, Ana, Álvarez, Alejandra R., Minniti, Alicia N., Rojas-Silva, Ximena, Muñoz, Luis L., Vasquez, Rodrigo, Rodriguez, Katherine, Sanchez-Navarro, Macarena, Giralt, Ernest, Araya, Eyleen, Aldunate, Rebeca, and Kogan, Marcelo J.

Published
2017
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24. Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors

Author

Lara, Pablo, Palma-Florez, Sujey, Salas-Huenuleo, Edison, Polakovicova, Iva, Guerrero, Simón, Lobos-Gonzalez, Lorena, Campos, America, Muñoz, Luis, Jorquera-Cordero, Carla, Varas-Godoy, Manuel, Cancino, Jorge, Arias, Eloísa, Villegas, Jaime, Cruz, Luis J., Albericio, Fernando, Araya, Eyleen, Corvalan, Alejandro H., Quest, Andrew F. G., and Kogan, Marcelo J.

Published
2020
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25. Impact of Ligand Exchange on Gold Nanostars' Reshaping, Stabilization, Photothermal Efficiency, and Cell Viability.

Author

Donoso-González, Orlando, Hengsbach, Rebecca, Ohlerth, Thorsten, Noyong, Michael, Sierpe, Rodrigo, Rozas-Castro, Nicolás, Lodeiro, Lucas, Bolaños, Karen, Melo, Francisco, Yutronic, Nicolás, Kogan, Marcelo J., and Simon, Ulrich

Abstract

Gold nanostars (AuNSs) have achieved special relevance for potential biomedical applications, e.g., in theranostics. In relation to this, some authors have explored controlling the conditions that trigger structural and morphological changes in these structures. In this work, we studied conditions that can trigger morphological changes of AuNSs or maintain their stability, such as ligand exchange to nonthiolated and thiolated species. First, the synthesis stabilizing ligand of AuNS, 4-(2-hydroxyethyl)-1-piperazinapropanesulfonic acid (EPPS), was exchanged for nonthiolated species to trigger or prevent morphological changes. One of these species, triphenylphosphine-monosulfonate (TPPMS), generated a stable and unexplored nanostructure even at acidic pH, with interaction mediated mainly by aromatic groups and the phosphine moiety, in comparison to hexadecyltrimethylammonium bromide (CTAB) and citrate, which are ligands that trigger morphological changes of AuNS. Moreover, TPPMS-coated AuNSs can be exchanged by thiolated species, such as carboxylated poly-(ethylene glycol) (HS-PEG-COOH), offering more versatility through covalent strategies. In addition, properties related to the application of these stabilized AuNSs were explored, such as photothermia and biocompatibility. The photothermal transduction efficiency and cell viability of AuNSs coated with EPPS, TPPMS, and PEG-COOH were evaluated, showing a temperature increment of the colloidal solutions and optimal mitochondrial activity. We believe that this work contributes to understanding the phenomena and conditions that trigger changes in the morphology or stability of AuNSs and that AuNSs coated with TPPMS and PEG-COOH possess optimal properties for potential biomedical applications. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Additional file 1 of Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model

Author

Palacios, Esteban, Lobos-González, Lorena, Guerrero, Simón, Kogan, Marcelo J., Shao, Baohai, Heinecke, Jay W., Quest, Andrew F. G., Leyton, Lisette, and Valenzuela-Valderrama, Manuel

Abstract

Additional file 1. Table S1. Identification of proteins with unique peptides in Helicobacter pylori (Hp) 60190 OMVs. The results of the LC–MS/MS analysis and the search using the Hp UniProtKB database (UP000000429.fasta) allowed to identify the total protein content of OMVs and the parental bacteria Hp 60190. The table shows the protein ID and the average number of unique peptides of proteins found in OMVs. Figure S1. Evaluation of the dose-response of the reactivity markers in DITNC1 ATCC astrocytes treated with different concentrations of OMVs from Helicobacter pylori (Hp) 60190. DITNC1 ATCC cells were incubated in the absence or presence of OMVs (1.25 to 20 µg/ml) from Hp 60190, at 37 °C for 24 h. As a positive reactivity control, the astrocytes were incubated with TNF (10 ng/ml, 48 h). After treatment, whole cell lysates were evaluated by immunoblot analysis of total connexin 43 (A), β3 integrin (B), GFAP (C), and vimentin (D), normalized to β-actin. Values in the graphs were obtained by averaging the immune-specific band intensity normalized to β-actin from 3 independent experiments (mean ± S.E.M). *p < 0.05 and **p < 0.01, compared to controls (Ctrl). Figure S2. Dose-response of the reactivity markers in DITNC1 ATCC astrocytes treated with 2.5 µg/ml of Helicobacter pylori (Hp) OMVs at different times. DITNC1 ATCC cells were incubated in the absence or presence of 2.5 µg/ml of Hp 60190 OMVs at 37 °C, from 3 to 72 h. As a positive reactivity control, the astrocytes were incubated with TNF (10 ng/ml, 48 h). After treatment, whole cell lysates were evaluated by immunoblot analysis of total connexin 43 (A), β3 integrin (B), GFAP (C), and vimentin (D), normalized to β-actin. Values in the graphs were obtained by averaging the immune-specific band intensity, normalized to β-actin, from 3 independent experiments (mean ± S.E.M). *p < 0,05, **p < 0.01, and ***p < 0.001, compared to controls (Ctrl). Figure S3. Effect of Helicobacter pylori (Hp) OMVs on astrocyte cell viability. Primary astrocytes (post 17 days in vitro) were incubated in the absence or presence of 2.5 µg/ml of OMVs for 12 h. Cell viability was evaluated with the Trypan blue assay in a Neubauer chamber. Values in the graph represent the average of the percentage of negative trypan blue cells from 3 independent experiments (mean ± S.E.M.). Figure S4. Effect of Helicobacter pylori (Hp) OMVs on p65 NF-ĸB subunit protein levels in DITNC1 ATCC astrocytes, following different times of exposure. DITNC1 ATCC cells were incubated in the absence or presence of 2.5 µg/ml of OMVs from 3 to 72 h, at 37 °C. As a positive reactivity control, the astrocytes were incubated with TNF (10 ng/ml, 48 h). After treatment, whole cell lysates were evaluated by immunoblot analysis of p65 NF-ĸB total levels. Values in the graph were obtained by averaging the immune-specific band intensity, normalized to β-actin, from 3 independent experiments (mean ± S.E.M). *p < 0.05, **p < 0.01, and ***p < 0.001, compared to controls (Ctrl). Table S2. Research Resource IdentifiersList of reagents, antibodies, inhibitors, kits, experimental models used in this study. Tee catalog number is included when available.

Published
2023
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37. Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer’s disease

Author

Morales-Zavala, Francisco, Casanova-Morales, Nathalie, Gonzalez, Raúl B., Chandía-Cristi, América, Estrada, Lisbell D., Alvizú, Ignacio, Waselowski, Victor, Guzman, Fanny, Guerrero, Simón, Oyarzún-Olave, Marisol, Rebolledo, Cristian, Rodriguez, Enrique, Armijo, Julien, Bhuyan, Heman, Favre, Mario, Alvarez, Alejandra R., Kogan, Marcelo J., and Maze, Jerónimo R.

Published
2018
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39. Gold nanostructures : synthesis, properties, and neurological applications

Author

Zare, Iman, Yaraki, Mohammad Tavakkoli, Speranza, Giorgio, Najafabadi, Alireza Hassani, Haghighi, Alireza Shourangiz, Nik, Amirala Bakhshian, Manshian, Bella B., Saraiva, Claudia, Soenen, Stefaan J., Kogan, Marcelo J., Lee, Jee Woong, Apollo, Nicholas V., Bernardino, Liliana, Araya, Eyleen, Mayer, Dirk, Mao, Guangzhao, Hamblin, Michael R., Zare, Iman, Yaraki, Mohammad Tavakkoli, Speranza, Giorgio, Najafabadi, Alireza Hassani, Haghighi, Alireza Shourangiz, Nik, Amirala Bakhshian, Manshian, Bella B., Saraiva, Claudia, Soenen, Stefaan J., Kogan, Marcelo J., Lee, Jee Woong, Apollo, Nicholas V., Bernardino, Liliana, Araya, Eyleen, Mayer, Dirk, Mao, Guangzhao, and Hamblin, Michael R.

Abstract

Recent advances in technology are expected to increase our current understanding of neuroscience. Nanotechnology and nanomaterials can alter and control neural functionality in both in vitro and in vivo experimental setups. The intersection between neuroscience and nanoscience may generate long-term neural interfaces adapted at the molecular level. Owing to their intrinsic physicochemical characteristics, gold nanostructures (GNSs) have received much attention in neuroscience, especially for combined diagnostic and therapeutic (theragnostic) purposes. GNSs have been successfully employed to stimulate and monitor neurophysiological signals. Hence, GNSs could provide a promising solution for the regeneration and recovery of neural tissue, novel neuroprotective strategies, and integrated implantable materials. This review covers the broad range of neurological applications of GNS-based materials to improve clinical diagnosis and therapy. Sub-topics include neurotoxicity, targeted delivery of therapeutics to the central nervous system (CNS), neurochemical sensing, neuromodulation, neuroimaging, neurotherapy, tissue engineering, and neural regeneration. It focuses on core concepts of GNSs in neurology, to circumvent the limitations and significant obstacles of innovative approaches in neurobiology and neurochemistry, including theragnostics. We will discuss recent advances in the use of GNSs to overcome current bottlenecks and tackle technical and conceptual challenges.

Published
2022
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45. Gold nanostructures: synthesis, properties, and neurological applications

Author

Zare, Iman, primary, Yaraki, Mohammad Tavakkoli, additional, Speranza, Giorgio, additional, Najafabadi, Alireza Hassani, additional, Shourangiz-Haghighi, Alireza, additional, Nik, Amirala Bakhshian, additional, Manshian, Bella B., additional, Saraiva, Cláudia, additional, Soenen, Stefaan J., additional, Kogan, Marcelo J., additional, Lee, Jee Woong, additional, Apollo, Nicholas V., additional, Bernardino, Liliana, additional, Araya, Eyleen, additional, Mayer, Dirk, additional, Mao, Guangzhao, additional, and Hamblin, Michael R., additional

Published
2022
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50. The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases

Author

Báez,Daniela F, Gallardo-Toledo,Eduardo, Oyarzún,María Paz, Araya,Eyleen, and Kogan,Marcelo J

Subjects
International Journal of Nanomedicine
Abstract

Daniela F Báez,1– 3,* Eduardo Gallardo-Toledo,1,2,* María Paz Oyarzún,1,2 Eyleen Araya,2,4 Marcelo J Kogan1,2 1Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile; 2Advanced Center for Chronic Diseases (ACCDIS), Santiago, Chile; 3Redox Process Research Center, CIPRex, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile; 4Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, Chile*These authors contributed equally to this workCorrespondence: Eyleen ArayaDepartamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, 8370035, ChileEmail eyleen.araya@unab.clMarcelo J KoganDepartamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, 8380494, ChileEmail mkogan@ciq.uchile.clAbstract: The physicochemical and optical properties of silver nanoparticles (SNPs) and gold nanoparticles (GNPs) have allowed them to be employed for various biomedical applications, including delivery, therapy, imaging, and as theranostic agents. However, since they are foreign body systems, they are usually redistributed and accumulated in some vital organs, which can produce toxic effects; therefore, this a crucial issue that should be considered for potential clinical trials. This review aimed to summarize the reports from the past ten years that have used SNPs and GNPs for in vivo studies on the diagnosis and treatment of brain diseases and those related to the central nervous system, emphasizing their toxicity as a crucial topic address. The article focuses on the effect of the nanoparticle´s size and chemical composition as relevant parameters for in vivo toxicity. At the beginning of this review, the general toxicity and distribution studies are discussed separately for SNPs and GNPs. Subsequently, this manuscript analyzes the principal applications of both kinds of nanoparticles for glioma, neurodegenerative, and other brain diseases, and discusses the advances in clinical trials. Finally, we analyze research prospects towards clinical applications for both types of metallic nanoparticles.Keywords: silver nanoparticles, gold nanoparticles, brain diseases, central nervous system, toxicity, in vivo applications

Published
2021

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