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3. Objective Tumor Response of Hepatocellular Carcinoma Obtained by Transarterial Radioembolization with Iodine-131-Lipiodol Versus Transarterial Chemoembolization for Patients with and without Portal Venous Thrombosis: A Controlled Interventional Trial

Author

Oliveira Ribeiro, Michele Costa de, Moda, Kerolyn Adorne, Alvarez, Matheus, Koga, Katia Hiromoto, Moriguchi, Sônia Marta, Carvalho, Fábio Cardoso, Pinheiro, Rafael Soares Nunes, Qi, Xingshun, and Romeiro, Fernando Gomes

Published
2024
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4. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author

Einstein, Andrew J., Paez, Diana, Dondi, Maurizio, Better, Nathan, Cerci, Rodrigo, Dorbala, Sharmila, Karthikeyan, Ganesan, Pascual, Thomas N.B., Shaw, Leslee J., Villines, Todd C., Vitola, Joao V., Williams, Michelle C., Pynda, Yaroslav, Hinterleitner, Gerd, Lu, Yao, Morozova, Olga, Xu, Zhuoran, Hirschfeld, Cole B., Cohen, Yosef, Erinne, Ikenna, Malkovskiy, Eli, Randazzo, Michael, Sewanan, Lorenzo, Shetty, Mrinali, Choi, Andrew, Lopez-Mattei, Juan, Parwani, Purvi, Goda, Artan, Shirka, Ervina, Bouyoucef, Salah, Chelghoum, Lydia, Mansouri, Farouk, Medjahedi, Abdelkader, Naili, Qais, Ridouh, Mokhtar, Alasia, Diego, Alberghina, Lucia, Aramayo, Natalia, Buchara, Diego, Busso, Franco Gabriel, Bustos Rivadero, Jose Javier, Camilletti, Jorge, Campanelli, Hugo, Campisi, Roxana, Castro, Ricardo Belisario, Daicz, Mariana, del Riego, Horacio, Dragonetti, Laura, Echazarreta, Diego, Erriest, Juan, Faccio, Fernando, Facello, Adolfo, Gallegos, Hugo, Geronazzo, Ricardo, Glait, Horacio, Hasbani, Victor, Jäger, Victor, Lewkowicz, Julio Manuel, Lotti, Jose, Maciel, Neiva, Masoli, Osvaldo, Mastrovito, Edgardo, Medus, Maria, Merani, Maria Fernanda, Molteni, Susana, Montecinos, Marcos, Parisi, Gustavo, Sueldo, Claudio Pereyra, Perez de Arenaza, Diego, Quintana, Luis, Radzinschi, Alejandro, Redruello, Marcela, Rodríguez, Marina, Rojas, Horacio, Acuña, Arturo Romero, Schere, Daniel, Traverso, Sonia, Vazquez, Gustavo, Zeffiro, Susana, Sakanyan, Mari, Beuzeville, Scott, Boktor, Raef, Crowley, Michael, Downie, D'Arne, Dwivedi, Girish, Elison, Barry, Farouque, Omar, Jasper, Kim, Joshi, Subodh, Lee, Joseph, Lee, Kenneth, Lui, Elaine, Mcconachie, Peter, Meaker, Joanne, Nandurkar, Dee, Neill, Johanne, O'Rourke, Edward, O'Sullivan, Patricia, Pandos, George, Premaratne, Manuja, Prior, David, Rutherford, Natalie, Saunders, Connor, Taubman, Kim, Tauro, Andrew, Taylor, Andrew, Theuerle, James, Thomas, Paul, Tow, Jonathan, Upton, Anthony, Vamadevan, Shankar, Wayne, Victor, Wegner, Eva Alina, Wong, David, Younger, John, Beitzke, Dietrich, Feuchtner, Gudrun, Sommer, Oliver, Weiss, Konrad, Maroz-Vadalazhskaya, Natallia, Tserakhau, Uladzimir, Homans, Filip, Van De Heyning, Caroline M., Araujo, Raúl, Soldat-Stankovic, Valentina, Stankovic, Sinisa, Almeida, Augusto, Anselmi, Carlos, Azevedo, Guilherme S.A., Bittencourt, Marcio Sommer, Pianta, Diego Bromfman, Cabeda, Estevan, Carreira, Lara, Coelho, Igor, de Amorim Fernandes, Fernando, de Lorenzo, Andrea, Delgado, Roberta, Erthal, Fernanda, Fernandes, Fabio, Fernandes, Juliano, Ferreira de Souza, Thiago, Foppa, Murilo, Matos Alves, Wilson Furlan, Gontijo, Cibele, Gottlieb, Ilan, Grossman, Gabriel, Albernaz Siqueira, Maria Helena, Nomura, Cesar Higa, Koga, Katia Hiromoto, Lima, Ronaldo, Lopes, Rafael, Marçal Filho, Hugo Humberto, Masiero, Paulo, Mastrocola, Luiz, Menezes de Siqueira, Maria Eduarda, Mesquita, Claudio, Naves, Danilo, Penna, Filipe, Pinto, Ibraim, Rocha, Thércio, Rocha, Juliana Leal, Rodrigues, Alfredo, Salioni, Leila, Sanches, Adelina, Santos, Marcelo, Da Silva, Leonardo Sara, Schvartzman, Paulo, Matushita, Cristina Sebastião, Senra, Tiago, Silva, Marcelo, Soares, Carlos Eduardo, Spiro, Bernardo, Suaide Silva, Carlos Eduardo, Torres, Rafael, Monte, Guilherme Urpia, Vilela, Andrea, Villa, Alexandre Volney, Vitola, Joao, Voss, Themissa, Waltrick, Roberto, Zapparoli, Marcello, Naseer, Hamid, Garcheva-Tsacheva, Marina, Ouattara, Tiémégna Florence, Thou, Sarameth, Varoeun, Soley, Abikhzer, Gad, Beanlands, Rob, Chetrit, Michael, Dabreo, Dominique, Dennie, Carole, Friedrich, Matthias, Hafez, Mohmmed Nassoh, Hanneman, Kate, Miller, Robert, Oikonomou, Anastasia, Roifman, Idan, Small, Gary, Tandon, Vikas, Trivedi, Adwait, White, James, Zukotynski, Katherine, Alay, Rita, Concha, Carmen, Massardo, Teresa, Abad, Pedro, Anzola, Kelly, Arturo, Harold, Benitez, Luis, Cadena, Alberto, Zamudio, Carlos Caicedo, Calderón, Antonio, Gutierrez Villamil, Claudia T., Jaimes, Claudia, Londono, Juan L., Lopez, Nelson, Merlano-Gaitan, Sonia, Murgieitio-Cabrera, Ramon, Valencia, Manuel, Vergel, Damiana, Santamaria, Alejandro Zuluaga, Solis, Felix, Batinic, Tonci, Franceschi, Maja, Paar, Maja Hrabak, Prpic, Marina, Felipe Batista, Cuba: Juan, Cabrera, Lazaro Omar, Peix, Amalia, Peña, Yamilé, Rochela Vázquez, Luis Manuel, Ntalas, Ioannis, Kaminek, Milan, Kincl, Vladimir, Lang, Otto, Abdulla, Jawdat, Bøttcher, Morten, Busk, Martin, Geisler, Uka, Gormsen, Lars C., Hansson, Nicolaj, Hess, Søren, Hove, Jens, Jensen, Lars Thorbjoern, Jensen, Magnus T., Kragholm, Kristian Hay, Nørgaard, Bjarne L., Øvrehus, Kristian, Rasmussen, Jan, Rønnow Sand, Niels Peter, Sondergaard, Hanne, Zaremba, Tomas, Speckter, Herwin, Amores, Nelson, Velez, Mayra Sanchez, Alrahman, Taghreed Abd, Elsamad, Sherif Abd, Abdelfattah, Alia, Allam, Adel, Elkaffas, Sameh, Hassan, Mona, Hussein, Elshaymaa, Ibrahim, Ahmed, Kandeel, Ahmed, Ali, Mohamed Mandour, Shaaban, Mahmoud, Flores, Camila, Gómez Leiva, Verónica Vanesa, Liiver, Anita, Larikka, Martti, Uusitalo, Valtteri, Agostini, Denis, Berger, Clothilde, Dietz, Matthieu, Hyafil, Fabien, Ohana, Mickaël, Prigent, Kevin, Regaieg, Hamza, Sarda-Mantel, Laure, H-Ici, Darach O., Ayetey, Harold, Angelidis, George, Fragkaki, Christina, Fragkiadaki, Chrysoula, Georgoulias, Panagiotis, Koutelou, Maria, Kyrozi, Elena, Lama, Niki, Prassopoulos, Vassilis, Spartalis, Michael, Zaglavara, Theodora, Gonzalez, Carla, Gutierrez, Goleat, Maldonado, Alejandro, Martinez, Yassine, Kovács, Attila, Szilveszter, Bálint, Banthia, Nilesh, Bhat, Vivek, Bhatia, Mona, Choudhury, Partha, Chowdekar, Vijay Sai, Christopher, Johann, Garg, Tushar, Goyal, Naresh Kumar, Gupta, Ripen Kumar, Gupta, Abhishek, Hephzibah, Julie, Jain, Shashank, Krupa, Jesu, Kumar, Parveen, Kumar, Sukriti, Lalchandani, Arati, Mishra, Animesh, Mishra, Vivaswan Dutt, Mohan, Parul, Ozair, Ahmad, Pandey, Shivani, Parameswaran, Ramanathapuram, Patel, Chetan, Patel, Tapan, Patel, Shivani, Vimala, Leena Robinson, Kumar Sarangi, Dr Pradosh, Sengupta, Shantanu, Sethi, Arvind, Sharma, Amit, Sharma, Awadhesh Kumar, Sharma, Punit, Shrigiriwar, Apurva, Singh, Santosh, Singh, Harpreet, Sood, Ashwani, Verma, Atul, Vyas, Ajay, Soeriadi, Erwin Affandi, Bun, Edison, Hutomo, Febby, Syawaluddin, Hilman, Yudistiro, Ryan, Albadr, Amjed, Assadi, Majid, Emami, Farshad, Emami-Ardekani, Alireza, Farzanehfar, Saeed, Jafari, Ramezan, Manafi-Farid, Reyhaneh, Tajik, Maryam, Arnson, Yoav, Fuchs, Shmuel, Goldkorn, Ronen, Kennedy, John, Leitman, Marina, Shalev, Aryeh, Acampa, Wanda, Albano, Domenico, Alongi, Pierpaolo, Arnone, Gaspare, Assante, Roberta, Baritussio, Anna, Bauckneht, Matteo, Bianco, Francesco, Bonfiglioli, Rachele, Bovenzi, Francesco, Bruno, Isabella, Bruno, Andrea, Busnardo, Elena, Califaretti, Elena, Casoni, Roberta, Censullo, Vittorio, Chierichetti, Franca, Chiocchi, Marcello, Cittanti, Corrado, Clemente, Alberto, Cuocolo, Alberto, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Della Tommasina, Veronica, Dellegrottaglie, Santo, Erba, Paola Anna, Evangelista, Laura, Faggi, Lara, Faragasso, Evelina, Florimonte, Luigia, Frantellizzi, Viviana, Gatti, Marco, Gaudiano, Angela, Gelardi, Fabrizia, Gerali, Alberto, Gimelli, Alessia, Guglielmo, Marco, Leccisotti, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Marcassa, Claudio, Matassa, Giovanni, Mele, Donato, Milan, Elisa, Mircoli, Luca, Paccagnella, Andrea, Pacella, Sara, Padovano, Federica, Pellegrini, Dario, Pergola, Valeria, Pugliese, Luca, Quartuccio, Natale, Rampin, Lucia, Ricci, Fabrizio, Rubini, Giuseppe, Russo, Vincenzo, Sambuceti, Gianmario, Scatteia, Alessandra, Sciagrà, Roberto, Spidalieri, Gianluca, Stefanelli, Antonella, Tedeschi, Carlo, Ventroni, Guido, Baugh, Dainia, Madu, Ernest, Aikawa, Tadao, Asano, Hiroshi, Fujimoto, Shinichiro, Fujise, Koichiro, Fukushima, Yoshimitsu, Fukuyama, Kae, Ichikawa, Yasutaka, Ideguchi, Reiko, Iguchi, Nobuo, Imai, Masamichi, Ishimura, Hayato, Isobe, Satoshi, Ito, Kimiteru, Izawa, Yu, Kadokami, Toshiaki, Kasai, Tokuo, Kato, Takao, Kawamoto, Takashi, Kiryu, Shigeru, Kumita, Shinichiro, Manabe, Osamu, Maruno, Hirotaka, Matsumoto, Naoya, Miyagawa, Masao, Moroi, Masao, Nagamachi, Shigeki, Nakajima, Kenichi, Nakazato, Ryo, Nanasato, Mamoru, Naya, Masanao, Norikane, Takashi, Ohta, Yasutoshi, Otomi, Yoichi, Otsuka, Hideki, Oyama-Manabe, Noriko, Saito, Masaki, Sarai, Masayoshi, Sato, Junichi, Sato, Daisuke, Shiraishi, Shinya, Takanami, Kentaro, Takehana, Kazuya, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Dautov, Tairkhan, Makhdomi, Khalid, Abass, Mostafa, Garashi, Masoud, Siraj, Qaisar, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Vajauskas, Donatas, Karim, Noor Khairiah A., Doucoure, Mady, Reichmuth, Luise, Samuel, Anthony, Dieng, Mohamed Lemine, Naojee, Ambedhkar Shantaram, Hernandez, Estrella Aguilera, Alducin Tellez, Cesar Rene, Alexánderson-Rosas, Erick, Barragan, Erika, Cabada, Manuel, Calderón, Daniel, Carvajal-Juarez, Isabel, Esparza, José, Gama-Moreno, Manlio Gerardo, Quinto, Virginia Garcia, Gonzalez, Nelsy Coromoto, Herrera-Zarza, Mary Carmen, Meave, Aloha, Medina Verdugo, Jesus Gregorio, Melendez, Gabriela, Morales Murguia, Rafael Humberto, Navarro Quiroz, Carlos Salvador, Ornelas, Mario, Preciado-Anaya, Andres, Preciado-Gutiérrez, Oscar Ulises, Puente, Adriana, Salazar, Aristóteles Ramírez, Rosales Uvera, Sandra Graciela, Rosales-Uvera, Sandra, Serna Macias, Jose Antonio, Sierra-Galan, Lilia, Sierra-Galan, Lilia M., Tirado Alderete, Juan Carlos, Vallejo, Enrique, Faraggi, Marc, Sereegotov, Erdenechimeg, Ben Rais, Nouzha, Alaoui, Nadia Ismaili, Kyiphyu, Thiri, Oo, Su Thet, Win, Soe Myat, Zar, Htin, Ghimire, Ram, Neupane, Madhu, Glaudemans, Andor, Slart, Riemer, Verschure, Derk, Allen, Berry, Edmond, John, Mckenzie, Clare, Tie, Stuart, Van Pelt, Niels, Worthington, Kirsten, Young, Calum, Soli, Idrissa Adamou, Kana, Shehu, Onubogu, Uchenna, Sani, Mahmoud, Bråten, Anders Tjellaug, Jørgensen, Arve, Vassbotn, Hanne-Elin, Al Dhuhli, Humoud, Jawa, Zabah, Tag, Naima, Fatima, Shazia, Imran, Muhammad Babar, Younis, Muhammad Numair, Saadullah, Mohammad, Malo, Yariela Herrera, Lenturut-Katal, Dora, Castillo, Manuel, Ortellado, José, Akhter, Afroza, Cader, F. Aaysha, Hussain, Raihan, Khan, Saidur Rahman, Mandal, Tapati, Nasreen, Faria, An, Yunqiang, Cao, Dianbo, Gong, Lianggeng, Hou, Yang, Jia, Chongfu, Li, Tao, Li, Caiying, Liu, Hui, Liu, Wenya, Liu, Jinkang, Lu, Bin, Ng, Ming-Yen, Shi, Heshui, Tang, Chunxiang, Wang, Ximing, Wang, Zhaoqian, Wang, Yining, Wu, Jiang, Yi, Yan, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Chavez, Edith, Cruz, Carlos, Llontop, Christian, Morales, Rosanna, Abrihan, Paz, Bustos-Barroso, Asela, Duldulao-Ogbac, Michele, Eduarte, Christopher, Obaldo, Jerry, Quinon, Alvin, San Juan, Belinda, San Juan, Carlo Joe, Sauler-Gomez, Marie Rhiamar, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Teresinska, Anna, Urbanik, Tomasz, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Gavina, Cristina, Gonçalves, Lino, Macedo, Filipe, Moreno, Nuno, Sousa, Carla, Timoteo, Ana Teresa, Vidigal, Maria João, Al Heidous, Mahmoud, Ramanathan, Subramaniyan, Arnous, Samer, Aytani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cheon, Miju, Cheon, Gi Jeong, Cho, Sang-Geon, Hong, Chae Moon, Jeong, Yong Hyu, Kang, Won Jun, Kang, Yeon-Koo, Kim, Ji-Young, Oh, So Won, So, Young, Song, Ho-Chun, Won, Kyoung Sook, Yoo, Soo Woong, Mitevska, Irena, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Pop, Marian, Stan, Claudiu, Ansheles, Alexey, Dariy, Olga, Gagarina, Nina, Itskovich, Irina, Karalkin, Anatoliy, Kokov, Alexander, Marina, Gulya, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Sayfullina, Guzaliya, Sergienko, Vladimir, Shurupova, Irina, Sinitsyn, Valentin, Vakhromeeva, Margarita, Valiullina, Nailia, Zavadovsky, Konstantin, Zhuravlev, Kirill, Abazid, Rami, Al Garni, Turki, Alasnag, Mirvat, Aljizeeri, Ahmed, Amer, Hamid, Amro, Ahmad, Hamdy, Hesham, Smettei, Osama, Saranovic, Dragana Sobic, Vlajkovic, Marina, Keng, Felix, See, Jason, Berecova, Zuzana, Mistinova, Jana Polakova, Evbuomwan, Osayande, Govender, Nerisha, Hack, Jonathan, Hadebe, Bawinile, Hlongwa, Khanyisile, Kaplan, Mitchell, Lakhi, Hoosen, Milos, Katarina, Modiselle, Moshe, More, Stuart, Muambadzi, Ntanganedzeni, Scholtz, Leonie, Barreiro-Perez, Manuel, Blanco, Isabel, Broncano, Jordi, Camarero, Alicia, Casáns-Tormo, Irene, De Haro, Javier, Flotats, Albert, García, Elia, Mendiguchia, Ceferino Gutierrez, Jimenez-Heffernan, Amelia, Leta, Ruben, Diaz, Javier Lopez, Vega, Luis Lumbreras, Manovel-Sánchez, Ana, Monzonis, Amparo Martinez, Patrut, Bianca, Pubul, Virginia, Perez, Ricardo Ruano, Zeidan, Nahla, Nanayakkara, Damayanthi, Suliman, Ahmed, Engblom, Henrik, Murtadha, Mustafa, Ostenfeld, Ellen, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Gräni, Christoph, Kamani, Christel, Kawel-Böhm, Nadine, Klaeser, Bernd, Manka, Robert, Prior, John, Kaewchur, Tawika, Khiewvan, Benjapa, Kositwattanarerk, Arpakorn, Namwongprom, Sirianong, Thientunyakit, Tanyaluck, Sayman, Haluk Burcak, Yüksel, Mahmut, Sebikali, Mugisha Julius, Okello, Emmy, Korol, Pavlo, Noverko, Iryna, Satyr, Maryna, Ahmad, Tahir, Alfakih, Khaled, Andrade, Ivo, Buckingham, Susan, Bularga, Anda, Carpenter, John-Paul, Cole, Graham, Cusack, David, David, Sarojini, Davis, Patrick, Fairbairn, Timothy, Ghosh, Arjun, Ramkumar, Prasad Guntur, Hamilton, Mark, Haque, Faisal, Hudson, Benjamin, Johnstone, Annette, Karthikeyan, V.J., Kay, Mike, Khan, Mohammad Ali, Kitt, Jamie, Low, Chen Sheng, Mcalindon, Elisa, Mccreavy, David, Morrissey, Brian, Motwani, Manish, Na, Dilip, Nicol, Edward, Patel, Dilip, Rodrigues, Jonathan, Rofe, Chris, Schofield, Rebecca, Semple, Thomas, Sheikh, Azeem, Sinha, Apurva, Subedi, Deepak, Topping, William, Tweed, Katherine, Underwood, Stephen Richard, Weir-Mccall, Jonathan, Zuhairy, Hamed, Abbasi, Taimur, Abohashem, Shady, Abramson, Sandra, Al-Mallah, Mouaz, Kumar, Mohan Ashok, Balmer-Swain, Mallory, Berman, Daniel, Bernheim, Adam, Bhatti, Sabha, Biederman, Robert, Bieging, Erik, Bingham, Scott, Bloom, Stephen, Blue, Sean, Borges, Andressa, Branch, Kelley, Bravo, Paco, Buddhe, Sujatha, Budoff, Matthew, Bullock-Palmer, Renée, Cahill, Michael, Candela, Candace, Cao, Jane, Chatterjee, Saurav, Chatzizisis, Yiannis, Chaudhuri, Nita Ray, Cheezum, Michael, Chelliah, Anjali, Chen, Tiffany, Chen, Marcus, Chen, Lu, Chokshi, Aalap, Chung, Jina, Danciu, Sorin, DeSisto, William, Dilorenzo, Michael, Doukky, Rami, Duvall, William, Ferencik, Maros, Foster, Cameron, Fuisz, Anthon, Gannon, Michael, German, David, Gerson, Myron, Geske, Jeffrey, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hendel, Robert, Henkel, Jacqueline, Horgan, Stephen, Hyun, Mark, Janardhanan, Rajesh, Jerome, Scott, Kalra, Dinesh, Kassop, David, Kinkhabwala, Mona, Kinzfogl, George, Koch, Bernard, Koweek, Lynne, Krepp, Joseph, Kwon, Younghoon, Layer, Jay, Lesser, John, Leung, Steve, Lisske, Bernadette, Magurany, Kathleen, Markowitz, Jeremy, Mccullough, Brenda, Moalemi, Azita, Moffitt, Chanan, Montanez, Juan, Moore, Warren, Morayati, Shamil, Mossa-Basha, Mahmud, Mrsic, Zorana, Murthy, Venkatesh, Nagpal, Prashant, Nelson, Katarina, Nijjar, Prabhjot, O’Quinn, Rupal, Passen, Edward, Patel, Toral, Patil, Pravin, Pursnani, Amit, Quachang, Nancy, Rabbat, Mark, Ranjan, Pragya, Lozano, Patricia Rodriguez, Schemmer, Mary, Seifried, Rebecca, Shah, Nishant, Shah, Amee, Shanbhag, Sujata, Sharma, Gaurav, Skotnicki, Robert, Sobczak, Michael, Soman, Prem, Sorrell, Vincent, Srichai, Monvadi, Streeter, Jim, Strickland, Leah, Suliman, Suliman, Tebyanian, Naghmeh, Thomas, Dustin, Thompson, Randall, Uretsky, Seth, Vallurupalli, Srikanth, Vandyck-Acquah, Marian, Verma, Vikas, Villines, Todd, Weinstein, Joseph, Wolinsky, David, Zareba, Karolina, Zgaljardic, Michael, Beretta, Mario, Ferrando, Rodolfo, Kapitan, Miguel, Mut, Fernando, Djuraev, Omoa, Rozikhodjaeva, Gulnora, Vera, Luisa, Duc, Binh Duong, Nguyen, Xuan Canh, Hiep Nguyen, Phuoc Minh, Hirschfeld, Cole, Choi, Andrew D., Ansheles, Alexey A., Kudo, Takashi, Bucciarelli-Ducci, Chiara, Nørgaard, Bjarne Linde, Maurovich-Horvat, Pál, Louw, Lizette, Allam, Adel H., and Narula, Jagat

Published
2022
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5. Basal or stimulated thyroglobulin in evaluating response to treatment in papillary thyroid carcinoma? A retrospective cohort study

Author

Barreto, Leticia, primary, Ferreira, Deborah Cristina Goulart, additional, Corrente, José Eduardo, additional, Soares, Carlos Segundo Paiva, additional, Oliveira, Cristiano Claudino, additional, Terra, Simone Antunes, additional, Moriguchi, Sonia Marta, additional, Koga, Katia Hiromoto, additional, Tagliarini, José Vicente, additional, and da Silva Mazeto, Gláucia Maria Ferreira, additional

Published
2023
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6. Objective Tumor Response of Hepatocellular Carcinoma Obtained by Transarterial Radioembolization with Iodine-131-Lipiodol Versus Transarterial Chemoembolization for Patients with and without Portal Venous Thrombosis: A Controlled Interventional Trial

Author

Oliveira Ribeiro, Michele Costa de, primary, Moda, Kerolyn Adorne, additional, Alvarez, Matheus, additional, Koga, Katia Hiromoto, additional, Moriguchi, Sônia Marta, additional, Carvalho, Fábio Cardoso, additional, Pinheiro, Rafael Soares Nunes, additional, Qi, Xingshun, additional, and Romeiro, Fernando Gomes, additional

Published
2023
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8. Cintilografia de mamas em câncer de mama triplo negativo – Avaliação do padrão e da predição de resposta quimioterápica/ Breast scintigraphy in triple negative breast cancer - Assessment of the pattern and prediction of chemotherapy response

Author

Koga, Katia Hiromoto, Moriguchi, Sonia Marta, Oikawa, Karina Hiromoto, Pessoa, Carla Priscila Kamiya Carvalho, Pessoa, Eduardo Carvalho, Tinóis, Eduardo, Vespoli, Heloisa Maria de Luca, and Filho, Benedito de Sousa Almeida

Subjects
triplo negativo, sestamibi-99mTc, General Medicine, quimioterapia neoadjuvante, carcinoma de mama, cintilografia de mamas
Abstract

Com intuito de detectar a predição da resposta ao tratamento quimioterápico em carcinoma de mama triplo negativo (CMTN), assim como, um padrão específico, propusemos a cintilografia de mamas com sestamibi-99mTc como método de diagnóstico para avaliação. Foram estudadas 49 pacientes, no período de 2011 a 2016, com diagnóstico de CMTN submetidas à cintilografia de mamas pré-quimioterapia neoadjuvante e avaliação do espécime cirúrgico. Na cintilografia de mamas foram avaliadas características qualitativas como intensidade de concentração do sestamibi-99mTc na lesão da mama e presença de acúmulo do mesmo em linfonodo axilar e quantitativa pela relação da área de interesse na lesão tumoral pela mesma área em espelho em tecido mamário sem alterações na mesma mama. A análise descritiva mostrou a idade 54,24 + 11,39 anos, com variação de 26 a 79 anos e mediana de 55 anos. A mama acometida pelo tumor foi 25 (51,0%) na mama direita e 24 (49,0%) esquerda. O esquema quimioterápico empregado nas pacientes foi de 36 (73,5%) com cloridrato de doxorrubicina, ciclofosfamida e placlitaxel e 13 (26,5%) com cloridrato de doxorrubicina e ciclofosfamida. Vinte e sete pacientes (55,1%) foram submetidas a mastectomia e 22 (44,9%) a quadrantectomia. A resposta patológica completa (RPC) foi presente em 18(36,7%) e ausente 31(63,3%). Na cintilografia, a análise quantitativa mostrou índice com média e desvio padrão de 2,58 + 1,01, com mínimo de 1,17 e máximo de 5,60 e mediana de 2,29. A análise qualitativa revelou intensidade de concentração em lesões na mama: discreta em 3(6,1%), moderada em 26(53,1) e acentuada em 20(40,8%). A concentração axilar foi visualizada na cintilografia de mamas em 41 pacientes (83,7%) e ausente em 8(16,3%). As associações dos dados cintilográficos quantitativo e qualitativo não mostraram significância estatística em predizer a resposta patológica completa. Em nosso estudo observamos uma predominância de lesões com maior intensidade de concentração do sestamibi-99mTc, o que ocorre em carcinomas de mama mais agressivos. No entanto, as análises quantitativa e qualitativa da cintilografia de mamas não puderam predizer a resposta patológica completa.

Published
2021

9. Escore preditor da eficácia da quimioterapia pré-operatório em carcinoma de mama localmente avançado / Predictive score of preoperative chemotherapy effectiveness in locally advanced breast carcinoma

Author

Koga, Katia Hiromoto, primary, Filho, Benedito de Sousa Almeida, additional, Rodrigues, Napoleão Ramalho, additional, Oikawa, Karina Hiromoto, additional, Moriguchi, Sonia Marta, additional, Pessoa, Eduardo Carvalho, additional, and Vespoli, Heloisa Maria De Luca, additional

Published
2021
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10. Thyroglobulin/thyrotropin ratio for predicting long-term response in differentiated thyroid carcinoma: a retrospective study

Author

Marchi, Adriano Francisco De, primary, Macedo, Ana Bárbara Trizzotti de, additional, Soares, Carlos Segundo Paiva, additional, Bolfi, Fernanda, additional, Iessi, Mariana Riello Gomes, additional, Oliveira, Cristiano Claudino de, additional, Koga, Katia Hiromoto, additional, Moriguchi, Sonia Marta, additional, Tagliarini, José Vicente, additional, and Mazeto, Gláucia Maria Ferreira da Silva, additional

Published
2021
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13. Desenvolvimento de um escore preditor da eficácia do tratamento quimioterápico pré-operatório em mulheres com carcinoma de mama localmente avançado

Author

Koga, Katia Hiromoto [UNESP], Universidade Estadual Paulista (Unesp), Nahas Neto, Jorge [UNESP], and Moriguchi, Sônia Marta [UNESP]

Subjects
Câncer - Quimioterapia, Mamas - Cancer - Tratamento, Breast Cancer, Diagnóstico imunohistoquímico, Tumores
Abstract

Made available in DSpace on 2014-08-13T14:50:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-11-01Bitstream added on 2014-08-13T18:01:06Z : No. of bitstreams: 1 000739118_20141101.pdf: 517878 bytes, checksum: 4a69194af4a75d682d3b9a625e2ead90 (MD5) Com intuito de desenvolver um escore preditor da resposta quimioterápica neoadjuvante, propusemos a cintilografia de mamas com sestamibi-99mTc, associada a fatores prognósticos como método preditor. Foram estudadas 65 pacientes com diagnóstico de carcinoma ductal submetidas à cintilografia de mamas préquimioterapia neoadjuvante (QT neo), painel imunohistoquímico e avaliação do espécime cirúrgico. A análise cintilográfica compreendeu a elaboração do índice de concentração, com áreas de interesse com contagens/pixels geradas sobre a lesão e na mama contralateral e cálculo da área tumoral. A analise estatística foi realizada para o grupo total de pacientes e separadamente para os grupos de esquema quimioterápico AC e ACT. Construiu-se um modelo de regressão logística utilizando como variáveis, idade, índice, localização do tumor, painel imunohistoquímico e comprometimento axilar, obtendo-se valores preditos que em função da resposta patológica completa foi elaborada uma curva ROC, para conseguir um escore de maior sensibilidade e especificidade. A área da curva ROC foi significativa para todos os grupos e o escore obtido foi de 0,728, 0,834 e 0,667 para o grupos total, AC e ACT, respectivamente. A sensibilidade, especificidade e valores preditivos positivo e negativo foram 81,6%, 81,2%, 93% e 59%, para o grupo total, 75,8%, 90%, 96,1% e 52,9%, para o grupo AC e 81,3%, 83,3%, 92,8% e 62,5%, para o grupo ACT. O escore preditor multifatorial é um método eficaz na predição da resposta quimioterápica neoadjuvante, uma vez, que reflete a biologia do tumor frente ao esquema quimioterápico, identificando precocemente as pacientes que não se beneficiariam deste tratamento In order to develop a prediction score of neoadjuvant chemotherapy response, we proposed the breast scintigraphy with 99mTc-sestamibi associated prognostic factors as predictor method. We studied 65 patients diagnosed with ductal carcinoma undergoing breast scintigraphy before neoadjuvant chemotherapy (QT neo), immunohistochemical panel and surgical specimens. The scintigraphic analysis included the development of uptake index made by counts/pixels in identical region of interest under tumor lesion and the reference region in the contra lateral breast and area calculation. The statistical analysis was performed for the total group of patients and separately for groups of AC chemotherapy regimen and ACT. Built a logistic regression model using variables, age, index, tumor location, immunohistochemical panel and axillary nodes, obtaining values predicted according to the complete pathologic response, ROC curve was drawn up, to get score a higher sensitivity and specificity. The area under the ROC curve was significant for all groups and the score obtained was 0.728, 0.834 and 0.667 for the groups total, AC and ACT, respectively. The sensitivity, specificity, and positive and negative predictive values were 81.6%, 81.2%, 93% and 59% for the total group, 75.8%, 90%, 96.1% and 52.9%, for the AC group and 81.3%, 83.3%, 92.8% and 62.5% for the ACT group. The multifactorial prediction score is an effective method for the prediction of neoadjuvant chemotherapy response, since that reflects the biology of the tumor against chemotherapy regimen, early identification of patients who would not benefit from this treatment

Published
2013

15. Cintilografia de mamas com sestamibi-99mTc na avaliação da resposta quimioterápica pré-operatória: análise quantitativa

Author

Koga, Katia Hiromoto [UNESP], Universidade Estadual Paulista (Unesp), Nahas Neto, Jorge [UNESP], and Moriguchi, Sônia Marta [UNESP]

Subjects
Exploração por radioisotopos, Breast cancer, Câncer - Quimioterapia, Cintilografia de mamas, Quimioterapia, Mamas - Cancer
Abstract

Made available in DSpace on 2014-06-11T19:29:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-19Bitstream added on 2014-06-13T19:25:50Z : No. of bitstreams: 1 koga_kh_me_botfm.pdf: 810706 bytes, checksum: 90f612f948b480a63317106b315ae4b6 (MD5) Avon Este estudo teve como objetivo principal avaliar a resposta tumoral ao tratamento quimioterápico neoadjuvante (QT neo) por meio da cintilografia de mamas com sestamibi-99mTc (CM) pelo método quantitativo. Estudo com 55 portadoras de CMLA, submetidas à QT neo que realizaram CM e o exame clínico (EC) pré e pós-quimioterapia e estudo do espécime cirúrgico. A quantificação da intensidade de concentração do sestamibi-99mTc foi realizada com cálculo de índice, de contagens/píxels de áreas de interesse idênticas criadas na lesão tumoral, sobre área de referência na mama contra-lateral. A resposta tumoral pela CM, pelo método quantitativo, foi determinada pela redução do índice entre os estudos pré e pós QT neo. O EC avaliou a redução da dimensão tumoral durante o tratamento, classificando-se a resposta em boa, parcial e inadequada. Houve correlação positiva, estatisticamente significativa, entre a redução do índice pela CM com a redução da dimensão tumoral pelo EC (p=O,001). Comparação de médias entre as ariáveis, redução do índice entre resposta clínica e tipo histológico, redução clínica tumor e resposta clínica e, índice pré-QT neo e redução do índice, apresentou-se significativa. Os achados da variação da concentração do sestamibi-99mTc na cintilografia de mamas pré e pós quimioterapia neoadjuvante nos permite utilizá-Ia mo método eficaz na avaliação da resposta quimioterápica neoadjuvante, uma vez, que esta quantificação reflete a biologia do tumor frente ao esquema quimioterápico. Além disso, a análise adicional do índice pré-quimioterápico sugere a utilidade para predizer a resposta ao tratamento quimioterápico. The main aim of this study was to evaluate the neoadjuvant chemotherapy (Neo QT) response by 99mTc-sestamibi scintimammography (SMM) through quantitative analysis. Fifty five bearers with locally advanced breast carcinoma (LABC) were undergone to Neo QT and had to SMM and clinical exam (CE) before and after chemotherapy and surgical specimen study. The 99mTc-sestamibi uptake index was made by counts/pixels in identical region of interest under tumor lesion and the refence region in the contra lateral breast. The tumour response by the index was determined by the rate reduction between the before and after Neo QT studies. The CE has evaluated the tumour size reduction during the treatment describing them as good response, partial and inadequate. Comparison of the means between variables reducing the rate of clinical response and histological type, clinical reduction of tumour and clinical response, and the pre Neo QT rate and reduction of the rate, proved to be significant. The findings of 99mTc-sestamibi uptake range on SMM before and after neoadjuvant chemotherapy allows us to use it as an effective method in the evaluation of neoadjuvant chemotherapy response once this quantification shows the biology of tumour before the chemotherapy treatment. The adictional analysis of pre chemotherapy index suggests the utility to predict the chemotherapy treatment response.

Published
2009

16. Lymphoscintigraphy detecting alterations of upper limb lymphatic flow following early sentinel lymph node biopsy in breast cancer.

Author

Sarri, Almir Jose, da Silva, Eduardo Tinois, da Costa Vieira, Rene Aloisio, Koga, Katia Hiromoto, Moriguchi Cação, Pedro Henrique, Sarri, Vitor Coca, and Moriguchi, Sonia Marta

Subjects
BREAST cancer, SENTINEL lymph node biopsy, BREAST surgery, LYMPHEDEMA, NUCLEAR medicine
Abstract

Purpose: To evaluate early variations in lymphatic circulation of the arm pre- and post-sentinel lymph node biopsy (SLNB) and conservative breast surgery by lymphoscintigraphy (LS). Patients and methods: Between 2005 and 2012, 15 patients underwent LS before and after the SLNB (total=30 studies). The pre-SLNB study was considered the control. Early images within twenty minutes (dynamic and static images) and delayed images within ninety minutes of arms and armpits were acquired using a gamma camera. The LS images before and after the SLNB of each patient were paired and compared to each other, evaluating the site of lymphatic flow (in the early phase) and identifying the number of lymph nodes (in the late phase). These dynamic images were subjected to additional quantitative analysis to assess the lymphatic flow rate using the slope assessed by the angular coefficient of the radioactivity × time curves in areas of interest recorded in the axillary region. The variations of lymphatic flow and the number of lymph nodes in the post-SLNB LS compared to the pre-SLNB LS of each patient were classified as decreased, sustained or increased. The clinical variables analyzed included the period between performing the SLNB and the subsequent LS imaging, age, body mass index, number of removed lymph nodes, type of surgery and whether immediate oncoplastic surgery was performed. Results: The mean age was 54.53±9.03 years (36-73 years), the mean BMI was 27.16±4.16 kg/m² (19.3-34.42), and the mean number of lymph nodes removed from each patient was 1.6±0.74 (1-3). There was significant difference in the time between surgery and the realization of LS (p=0.002; Mann-Whitney U test), but in an inverse relationship, the higher was the range, the smaller was the lymphatic flow, indicating a gradual reduction of lymphatic flow after surgery (Spearman's p=0.498, with p=0.013). Conclusion: Upper limb lymphatic flow gradually decreased after the SLNB and conservative breast surgery in this study, but these results are exploratory because of the small sample size. Further studies are needed to confirm and to investigate more in depth these findings. [ABSTRACT FROM AUTHOR]

Published
2017
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17. 99mTc-sestamibi scintigraphy used to evaluate tumor response to neoadjuvant chemotherapy in locally advanced breast cancer: A quantitative analysis

Author

KOGA, KATIA HIROMOTO, primary, MORIGUCHI, SONIA MARTA, additional, NETO, JORGE NAHÁS, additional, PERES, STELA VERZINHASSE, additional, SILVA, EDUARDO TINÓIS DA, additional, SARRI, ALMIR JOSÉ, additional, MICHELIN, ODAIR CARLITO, additional, MARQUES, MARIANGELA ESTHER ALENCAR, additional, and GRIVA, BEATRIZ LOTUFO, additional

Published
2010
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18. Evaluation of solid gastric emptying in obese patients

Author

Ribeiro, Daniela Furuzawa, Universidade Estadual Paulista (Unesp), Nogueira, Célia Regina [UNESP], and Koga, Katia Hiromoto [UNESP]

Subjects
obesidade, sistema gastrointestinal motilidade, índice de massa corporal, obesidade em mulheres
Abstract

Submitted by DANIELA FURUZAWA RIBEIRO (dani_furuzawa@yahoo.com.br) on 2019-07-30T21:04:11Z No. of bitstreams: 1 Dissertação mestrado pdf.pdf: 1328258 bytes, checksum: 4280224dd288eccf829cad9b2e739643 (MD5) Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2019-07-31T16:44:20Z (GMT) No. of bitstreams: 1 ribeiro_df_me_bot_par.pdf: 914931 bytes, checksum: 4483904cdfbc6b421e6c0d2ba58ae8dd (MD5) Made available in DSpace on 2019-07-31T16:44:20Z (GMT). No. of bitstreams: 1 ribeiro_df_me_bot_par.pdf: 914931 bytes, checksum: 4483904cdfbc6b421e6c0d2ba58ae8dd (MD5) Previous issue date: 2019-07-29 Estudos epidemiológicos demonstram um acelerado aumento do número de indivíduos com obesidade em quase todo o mundo. A fisiopatologia da obesidade ainda não está bem elucidada, mas sabe-se que o controle do peso corporal está relacionado a diversos hormônios, sinalizadores celulares e neurônios do Sistema Nervoso Central que regulam o apetite e o balanço energético. Nesse contexto, o tempo de esvaziamento gástrico (TEG) poderia influenciar na fisiopatologia da doença, visto estar relacionado à secreção de hormônios reguladores da fome e da saciedade. Considera-se, a cintilografia como diagnóstico padrão-ouro de anormalidades no TEG. Esse procedimento ocorre com a ingestão de fonte radioativa não selada. Diante disso, avaliamos o TEG sólido em pacientes obesos por meio da cintilografia de esvaziamento gástrico sólido e sua relação com o índice de massa corporal (IMC) dos pacientes. Fizeram parte do estudo 45 mulheres com idade entre 18 e 50 anos, IMC > 35 kg/m2, acompanhadas no ambulatório de gastrocirurgia da Faculdade de Medicina de Botucatu. Foram obtidos dados antropométricos e exames laboratoriais com amostras de sangue, sendo dosados transaminase glutâmico-oxalacética (TGO), transaminase glutâmico pirúvica (TGP), glicemia de jejum, hemoglobina glicada, hormônio tireoestimulante (TSH) e hormônio tiroxina livre (T4 livre). Os resultados mostraram que a maioria dessa população era constituída por mulheres brancas (80%), não tabagistas (91,1%), não etilistas (95,6%), com idade média de 38,27 anos, peso médio de 125,92 kg, altura média de 1,63 metros, IMC médio de 47,56 kg/m2, escolaridade até ensino médio (37,8%), com perfil lipídico e glicêmico normal, sem alteração da função renal, hepática ou tireoideana. Em relação à cintilografia de esvaziamento gástrico sólido, foram realizados 36 exames, a maioria (n=24) apresentou resultado normal e as demais, resultado acelerado (n=12), sem correlação entre o IMC e o resultado da cintilografia. O esvaziamento gástrico acelerado poderia estar relacionado com uma sensação de saciedade menor, o que aumentaria a frequência de ingestão de refeições. Não houve diferença entre os resultados com relação à cor da pele, escolaridade, tabagismo e etilismo. Os dados obtidos foram concordantes com os já descritos na literatura. Concluímos que o IMC não está relacionado com o TEG sólido e que são necessários mais estudos sobre o tema para elucidar melhor essa questão. Epidemiological studies have shown an accelerated increase in the number of obese individuals in almost the entire world. The pathophysiology of obesity has not yet been fully elucidated, but it is known that body weight control is related to several hormones, cellular signals and neurons of the Central Nervous System that regulate appetite and energy balance. In this context, gastric emptying time (GET) could influence the pathophysiology of the disease, since it is related to the secretion of hormones regulating hunger and satiety. Scintigraphy is considered the gold standard diagnosis of TEG abnormalities. This procedure occurs with ingestion of unsealed radioactive source. Therefore, we evaluated solid GET in obese patients through solid gastric emptying scintigraphy and its relation to the patient's body mass index (BMI). The study included 43 women aged between 18 and 50 years, BMI> 35 kg / m2, accompanied at the gastro-surgery outpatient clinic of the Botucatu Medical School. Anthropometric data and laboratory tests were obtained with blood samples, being measured glutamic-oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), fasting glycemia, glycated hemoglobin, thyroid stimulating hormone (TSH) and free thyroxine (free T4). The results showed that the majority of this population consisted of white women (80%), non-smokers (91.1%), non-alcoholics (95.6%), mean age 38.27 years, mean weight 125, 92 kg, mean height of 1.63 meters, mean BMI of 47.56 kg / m2, schooling until high school (37.8%), with normal lipid and glycemic profile, without alteration of renal, hepatic or thyroid function. Regarding solid gastric emptying scintigraphy, 36 examinations were performed, the majority (n = 24) presented a normal result and the others had an accelerated result (n = 12), with no correlation between BMI and scintigraphy results. Accelerated gastric emptying may be related to a lower satiety, which would increase the frequency of meal intake. There were no differences between results regarding skin color, schooling, smoking and alcohol consumption. The data obtained were in agreement with those already described in the literature. We conclude that BMI is not related to solid GET and that further studies are needed to elucidate this issue better.

Published
2019

19. Thyroglobulin/thyrotropin ratio for predicting long-term response in differentiated thyroid carcinoma: a retrospective study.

Author

De Marchi AF Junior, de Macedo ABT, Soares CSP, Bolfi F, Iessi MRG, de Oliveira CC, Koga KH, Moriguchi SM, Tagliarini JV, and da Silva Mazeto GMF

Subjects
Humans, Prognosis, Retrospective Studies, Thyroidectomy, Thyrotropin, Treatment Outcome, Thyroglobulin, Thyroid Neoplasms surgery
Abstract

Objective: Thyrotropin-stimulated thyroglobulin (STg) after total thyroidectomy is a prognosis marker for differentiated thyroid carcinoma (DTC). As Tg level is influenced by thyrotropin (TSH), perhaps the STg/TSH ratio is also a prognosis marker for these tumours. We aimed to compare STg/TSH ratio and first STg level in differentiated thyroid carcinoma patients for their ability to predict the long-term response to initial treatment., Methods: This retrospective study evaluated data from 181 DTC patients for first (1 st ) STg and STg/TSH ratio, at 1-3 months post-total thyroidectomy and before iodine-131 therapy, according to response to initial therapy [Excellent/Indeterminate or Incomplete (Biochemical/Structural)] observed at final evaluation, and with the survival time with excellent/indeterminate response., Results: Cases with incomplete response presented higher STg level [225.13 ± 585.26 ng/mL versus (vs) 20.4 ± 192.9 ng/mL; p < 0.001] and STg/TSH ratio (3.01 ± 7.8 vs 0.27 ± 2.58; p < 0.001). Cutoffs of 5 ng/mL for STg and 0.085 for STg/TSH displayed sensitivities of 76.7% and 76.9%, and specificities of 79.2% and 82.6%, respectively, in predicting response to therapy. Values below these cutoffs were associated with longer survival time in excellent/indeterminate response (140.4 vs 15.9 and 144.6 vs 15.9 months, respectively)., Conclusion: STg/TSH ratio has a similar performance to the 1 st STg in predicting long-term response to initial therapy.

Published
2021
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20. Lymphoscintigraphy detecting alterations of upper limb lymphatic flow following early sentinel lymph node biopsy in breast cancer.

Author

Sarri AJ, Tinois da Silva E, Vieira RADC, Koga KH, Cação PHM, Sarri VC, and Moriguchi SM

Abstract

Purpose: To evaluate early variations in lymphatic circulation of the arm pre- and post-sentinel lymph node biopsy (SLNB) and conservative breast surgery by lymphoscintigraphy (LS)., Patients and Methods: Between 2005 and 2012, 15 patients underwent LS before and after the SLNB (total=30 studies). The pre-SLNB study was considered the control. Early images within twenty minutes (dynamic and static images) and delayed images within ninety minutes of arms and armpits were acquired using a gamma camera. The LS images before and after the SLNB of each patient were paired and compared to each other, evaluating the site of lymphatic flow (in the early phase) and identifying the number of lymph nodes (in the late phase). These dynamic images were subjected to additional quantitative analysis to assess the lymphatic flow rate using the slope assessed by the angular coefficient of the radioactivity × time curves in areas of interest recorded in the axillary region. The variations of lymphatic flow and the number of lymph nodes in the post-SLNB LS compared to the pre-SLNB LS of each patient were classified as decreased, sustained or increased. The clinical variables analyzed included the period between performing the SLNB and the subsequent LS imaging, age, body mass index, number of removed lymph nodes, type of surgery and whether immediate oncoplastic surgery was performed., Results: The mean age was 54.53±9.03 years (36-73 years), the mean BMI was 27.16±4.16 kg/m 2 (19.3-34.42), and the mean number of lymph nodes removed from each patient was 1.6±0.74 (1-3). There was significant difference in the time between surgery and the realization of LS ( p =0.002; Mann-Whitney U test), but in an inverse relationship, the higher was the range, the smaller was the lymphatic flow, indicating a gradual reduction of lymphatic flow after surgery (Spearman's p =0.498, with p =0.013)., Conclusion: Upper limb lymphatic flow gradually decreased after the SLNB and conservative breast surgery in this study, but these results are exploratory because of the small sample size. Further studies are needed to confirm and to investigate more in depth these findings., Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Published
2017
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