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1. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, Rachel M, Klein, Marieke, Grasby, Katrina L, Schnack, Hugo G, Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I, Sprooten, Emma, Franz, Carol E, Gogtay, Nitin, Kremen, William S, Panizzon, Matthew S, Olde Loohuis, Loes M, Whelan, Christopher D, Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J, Bastin, Mark E, Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A, Bright, Joanna K, Buimer, Elizabeth EL, Bülow, Robin, Cannon, Dara M, Ciufolini, Simone, Crossley, Nicolas A, Damatac, Christienne G, Dazzan, Paola, de Mol, Casper L, de Zwarte, Sonja MC, Desrivières, Sylvane, Díaz-Caneja, Covadonga M, Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H, Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura KM, Harris, Mathew A, Hartman, Catharina A, Heany, Sarah J, Heindel, Walter, Heslenfeld, Dirk J, Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R, Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn GJC, Lenroot, Rhoshel K, Malchow, Berend, Mandl, René CW, Medel, Vicente, Meinert, Susanne, Morgan, Catherine A, Mühleisen, Thomas W, Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J, Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V, Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje EM, Wardlaw, Joanna M, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H, Zugman, Andre, Armstrong, Nicola J, Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J, and Gonzalez-Peñas, Javier

Subjects
Biological Psychology, Psychology, Genetics, Biomedical Imaging, Mental Health, Biotechnology, Human Genome, Prevention, Aging, Brain Disorders, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Mental health, Neurological, Brain, Genome-Wide Association Study, Humans, Longevity, Magnetic Resonance Imaging, IMAGEN Consortium, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

Published
2022

2. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

van den Heuvel, Martijn P, Scholtens, Lianne H, van der Burgh, Hannelore K, Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon JNL, Beyer, Frauke, Booij, Linda, Braun, Kees PJ, Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M, Chaim-Avancini, Tiffany M, Chan, Sandra SM, Chen, Eric YH, Crespo-Facorro, Benedicto, Crone, Eveline A, Dannlowski, Udo, de Zwarte, Sonja MC, Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Díaz-Caneja, Covadonga M, Díaz-Zuluaga, Ana M, Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M, Holleran, Laurena, Holt, Rosemary, Hopman, Helene J, Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn GJC, Kostic, Vladimir S, Krug, Axel, Lawrie, Stephen M, Lebedeva, Irina S, Lee, Edwin HM, Lett, Tristram A, Lewis, Simon JG, Liem, Franziskus, Lombardo, Michael V, Lopez-Jaramillo, Carlos, Margulies, Daniel S, Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M, McPhilemy, Genevieve, Meinert, Susanne L, Menchón, José M, Montag, Christian, Moreira, Pedro S, Morgado, Pedro, Mothersill, David O, Mérillat, Susan, Müller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, de la Foz, Victor Ortiz-Garcia, Peper, Jiska S, Pineda, Julian A, Rasser, Paul E, Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro GP, Ruigrok, Amber NV, Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S, Tordesillas-Gutierrez, Diana, Valk, Sofie L, and van den Berg, Leonard H

Subjects
Biological Psychology, Psychology, Biomedical Imaging, Brain Disorders, Neurosciences, Neurological, MRI, connectome analysis, diffusion weighted MRI, brain, network, Clinical Sciences, Clinical sciences, Biological psychology
Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.

Published
2019

7. The Association Between Emotion Recognition, Affective Empathy, and Structural Connectivity in Schizophrenia Patients

Author

Koevoets, Martijn G.J.C., Prikken, Merel, Hagenaar, Doesjka A., Kahn, René S., van Haren, Neeltje E.M., and Child and Adolescent Psychiatry / Psychology

Subjects
Psychiatry and Mental health, SDG 3 - Good Health and Well-being
Abstract

IntroductionEmotion processing deficits often occur in patients with schizophrenia. We investigate whether patients and controls differ in the association between facial emotion recognition and experience of affective empathy and whether performance on these emotion processing domains differently relates to white matter connectivity.Materials and MethodsForty-seven patients with schizophrenia and 47 controls performed an emotion recognition and affective empathy task. T1-weighted and diffusion-tensor images (DTI) of the brain were acquired. Using Tracula 5.3, ten fibers were reconstructed and fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were extracted. Groups were compared on task performance, white matter measures and their interactions using ANCOVAs. Correction for multiple comparisons was applied.ResultsPatients scored lower on emotion recognition (p = 0.037) and reported higher levels of affective empathy (p < 0.001) than controls. Patients with poor emotion recognition (PT-low) experienced stronger affective empathy than patients with similar emotion recognition performance as controls (PT-normal; p = 0.011), who in turn reported stronger affective empathy than controls (p = 0.043). We found a significant interaction between emotion recognition, affective empathy and anterior thalamic radiation AD (p = 0.017, d = 0.43). Post hoc analyses revealed that the correlation between AD and empathy differed significantly between all groups (empathy/AD in PT-low < empathy/AD in PT-normal < empathy/AD in controls).DiscussionIn patients with poor emotion recognition, the negative association between anterior thalamic radiation AD and affective empathy was stronger than in patients with normal emotion recognition capacity. Possibly, axonal damage in fronto-thalamic structural connections, as part of a larger frontotemporal network, underlies the association between poor emotion recognition and higher levels of affective empathy in schizophrenia patients.

Published
2022
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8. The Association Between Emotion Recognition, Affective Empathy, and Structural Connectivity in Schizophrenia Patients

Author

Brain, Affectieve & Psychotische Med., Onderzoeksgroep 11, Onderzoeksgroep 1, Koevoets, Martijn G.J.C., Prikken, Merel, Hagenaar, Doesjka A., Kahn, René S., van Haren, Neeltje E.M., Brain, Affectieve & Psychotische Med., Onderzoeksgroep 11, Onderzoeksgroep 1, Koevoets, Martijn G.J.C., Prikken, Merel, Hagenaar, Doesjka A., Kahn, René S., and van Haren, Neeltje E.M.

Published
2022

9. Alcohol use and brain morphology in adolescence: A longitudinal study in three different cohorts

Author

El Marroun, Hanan, primary, Klapwijk, Eduard T., additional, Koevoets, Martijn, additional, Brouwer, Rachel M., additional, Peters, Sabine, additional, van't Ent, Dennis, additional, Boomsma, Dorret I., additional, Muetzel, Ryan L., additional, Crone, Eveline A., additional, Hulshoff Pol, Hilleke E., additional, and Franken, Ingmar H. A., additional

Published
2021
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10. Alcohol use and brain morphology in adolescence:A longitudinal study in three different cohorts

Author

El Marroun, Hanan, Klapwijk, E.T. (Eduard), Koevoets, Martijn, Brouwer, Rachel M., Peters, S. (Sabine), van't Ent, Dennis, Boomsma, Dorret I., Muetzel, Ryan L., Crone, Eveline A., Hulshoff Pol, Hilleke E., Franken, Ingmar H.A., El Marroun, Hanan, Klapwijk, E.T. (Eduard), Koevoets, Martijn, Brouwer, Rachel M., Peters, S. (Sabine), van't Ent, Dennis, Boomsma, Dorret I., Muetzel, Ryan L., Crone, Eveline A., Hulshoff Pol, Hilleke E., and Franken, Ingmar H.A.

Abstract

Alcohol consumption is commonly initiated during adolescence, but the effects on human brain development remain unknown. In this multisite study, we investigated the longitudinal associations of adolescent alcohol use and brain morphology. Three longitudinal cohorts in the Netherlands (BrainScale n = 200, BrainTime n = 239 and a subsample of the Generation R study n = 318) of typically developing participants aged between 8 and 29 years were included. Adolescent alcohol use was self-reported. Longitudinal neuroimaging data were collected for at least two time points. Processing pipelines and statistical analyses were harmonized across cohorts. Main outcomes were global and regional brain volumes, which were a priori selected. Linear mixed effect models were used to test main effects of alcohol use and interaction effects of alcohol use with age in each cohort separately. Alcohol use was associated with adolescent's brain morphology showing accelerated decrease in grey matter volumes, in particular in the frontal and cingulate cortex volumes, and decelerated increase in white matter volumes. No dose–response association was observed. The findings were most prominent and consistent in the older cohorts (BrainScale and BrainTime). In summary, this longitudinal study demonstrated differences in neurodevelopmental trajectories of grey and white matter volume in adolescents who consume alcohol compared with non-users. These findings highlight the importance to further understand underlying neurobiological mechanisms when adolescents initiate alcohol consumption. Therefore, further studies need to determine to what extent this reflects the causal nature of this association, as this longitudinal observational study does not allow for causal inference.

Published
2021

11. Alcohol use and brain morphology in adolescence: a longitudinal study in three different cohorts

Author

Brain, Onderzoeksgroep 1, El Marroun, Hanan, Klapwijk, Eduard T, Koevoets, Martijn, Brouwer, Rachel M, Peters, Sabine, van 't Ent, Dennis, Boomsma, Dorret I, Muetzel, Ryan, Crone, Eveline A, Hulshoff Pol, Hilleke E, Franken, Ingmar H A, Brain, Onderzoeksgroep 1, El Marroun, Hanan, Klapwijk, Eduard T, Koevoets, Martijn, Brouwer, Rachel M, Peters, Sabine, van 't Ent, Dennis, Boomsma, Dorret I, Muetzel, Ryan, Crone, Eveline A, Hulshoff Pol, Hilleke E, and Franken, Ingmar H A

Published
2021

12. Brain structure, IQ, and psychopathology in young offspring of patients with schizophrenia or bipolar disorder

Author

Onderzoeksgroep 1, Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Diagnostiek & Vroege Psychose Medisch, van Haren, Neeltje E M, Setiaman, Nikita, Koevoets, Martijn G J C, Baalbergen, Heleen, Kahn, Rene S, Hillegers, Manon H J, Onderzoeksgroep 1, Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Diagnostiek & Vroege Psychose Medisch, van Haren, Neeltje E M, Setiaman, Nikita, Koevoets, Martijn G J C, Baalbergen, Heleen, Kahn, Rene S, and Hillegers, Manon H J

Published
2020

14. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, de Lange, Siemon C., van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, and de Lange, Siemon C.

Published
2019

15. Visualizing mental representations in schizophrenia patients: A reverse correlation approach

Author

Leerstoel Aarts, Social-cognitive and interpersonal determinants of behaviour, Brinkman, Loek, Dotsch, Ron, Zondergeld, Jelmer, Koevoets, Martijn G.J.C., Aarts, Henk, van Haren, Neeltje E.M., Leerstoel Aarts, Social-cognitive and interpersonal determinants of behaviour, Brinkman, Loek, Dotsch, Ron, Zondergeld, Jelmer, Koevoets, Martijn G.J.C., Aarts, Henk, and van Haren, Neeltje E.M.

Published
2019

17. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

Onderzoeksgroep 6, Projectafdeling ALS, Brain, MS Neonatologie, Child Health, ZL Kinder Ner en Nec Medisch, Onderzoek, Ontwikkelingsstoornissen Ond., Onderzoek Bob Oranje, Onderzoeksgroep 1, ZL Neuromusculaire Ziekten Medisch, Regenerative Medicine and Stem Cells, Psychiatrie_Medisch, van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, de Lange, Siemon C., Onderzoeksgroep 6, Projectafdeling ALS, Brain, MS Neonatologie, Child Health, ZL Kinder Ner en Nec Medisch, Onderzoek, Ontwikkelingsstoornissen Ond., Onderzoek Bob Oranje, Onderzoeksgroep 1, ZL Neuromusculaire Ziekten Medisch, Regenerative Medicine and Stem Cells, Psychiatrie_Medisch, van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, and de Lange, Siemon C.

Published
2019

18. 10kin1day:A bottom-up neuroimaging initiative

Author

Van Den Heuvel, Martijn P., Scholtens, Lianne H., Van Der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J.N.L., Beyer, Frauke, Booij, Linda, Braun, Kees P.J., Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S.M., Chen, Eric Y.H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, De Zwarte, Sonja M.C., Dietsche, Bruno, Donohoe, Gary, Plessis, Stefan Du, Durston, Sarah, Díaz-Caneja, Covadonga M., Díaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G.J.C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H.M., Lett, Tristram A., Lewis, Simon J.G., Liem, Franziskus, Lombardo, Michael V., Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchón, José M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Mérillat, Susan, Müller, Hans Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, De la Foz, Victor Ortiz Garcia, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G.P., Ruigrok, Amber N.V., Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., Van Den Berg, Leonard H., Van Erp, Theo G.M., Van Haren, Neeltje E.M., Van Leeuwen, Judith M.C., Villringer, Arno, Vinkers, Christiaan H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, De Lange, Siemon C., Van Den Heuvel, Martijn P., Scholtens, Lianne H., Van Der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J.N.L., Beyer, Frauke, Booij, Linda, Braun, Kees P.J., Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S.M., Chen, Eric Y.H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, De Zwarte, Sonja M.C., Dietsche, Bruno, Donohoe, Gary, Plessis, Stefan Du, Durston, Sarah, Díaz-Caneja, Covadonga M., Díaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G.J.C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H.M., Lett, Tristram A., Lewis, Simon J.G., Liem, Franziskus, Lombardo, Michael V., Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchón, José M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Mérillat, Susan, Müller, Hans Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, De la Foz, Victor Ortiz Garcia, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G.P., Ruigrok, Amber N.V., Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., Van Den Berg, Leonard H., Van Erp, Theo G.M., Van Haren, Neeltje E.M., Van Leeuwen, Judith M.C., Villringer, Arno, Vinkers, Christiaan H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, and De Lange, Siemon C.

Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain. Ongoing grand-scale projects like the European Human Brain Project (1), the US Brain Initiative (2), the Human Connectome Project (3), the Chinese Brainnetome (4) and exciting world-wide neuroimaging collaborations such as ENIGMA (5) herald the new era of big neuroscience. In conjunction with these major undertakings, there is an emerging trend for bottom-up initiatives, starting with small-scale projects built upon existing collaborations and infrastructures. As described by Mainen et al. (6), these initiatives are centralized around self-organized groups of researchers working on the same challenges and sharing interests and specialized expertise. These projects could scale and open up to a larger audience and other disciplines over time, eventually lining up and merging their findings with other programs to make the bigger picture.

Published
2019

19. 10Kin1day: A bottom-up neuroimaging initiative

Author

Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Merillat, Susan, Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Naumczyk, Patrycja, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rosa, Pedro G. P., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Serpa, Mauricio H., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, van Erp, Theo G. M., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Valk, Sofie L., van den Berg, Leonard H., Vollmar, Christian, van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Waller, Lea, Walter, Henrik, Whalley, Heather, Witkowska, Marta, Booij, Linda, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, de Lange, Siemon C., Chaim-Avancini, Tiffany M., Braun, Kees P. J., Busatto, Geraldo F., Cahn, Wiepke, Cannon, Dara M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Filippi, Massimo, Durston, Sarah, Díaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Kaleda, Vasiliy G., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina, Lee, Edwin H. M., Lopez-Jaramillo, Carlos, Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V., Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Merillat, Susan, Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Naumczyk, Patrycja, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rosa, Pedro G. P., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Serpa, Mauricio H., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, van Erp, Theo G. M., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Valk, Sofie L., van den Berg, Leonard H., Vollmar, Christian, van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Waller, Lea, Walter, Henrik, Whalley, Heather, Witkowska, Marta, Booij, Linda, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, de Lange, Siemon C., Chaim-Avancini, Tiffany M., Braun, Kees P. J., Busatto, Geraldo F., Cahn, Wiepke, Cannon, Dara M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Filippi, Massimo, Durston, Sarah, Díaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Kaleda, Vasiliy G., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina, Lee, Edwin H. M., Lopez-Jaramillo, Carlos, Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V., Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, and Martínez-Zalacaín, Ignacio

Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.

Published
2019

22. Abnormal agency experiences in schizophrenia patients: examining the role of psychotic symptoms and familial risk

Author

Leerstoel Ridder, Leerstoel Aarts, Stress and self-regulation, Social-cognitive and interpersonal determinants of behaviour, Prikken, Merel, van der Weiden, A., Renes, R.A., Koevoets, Martijn G J C, Heering, H.D., Kahn, R.R., Aarts, H., Haren, N.E.M., Leerstoel Ridder, Leerstoel Aarts, Stress and self-regulation, Social-cognitive and interpersonal determinants of behaviour, Prikken, Merel, van der Weiden, A., Renes, R.A., Koevoets, Martijn G J C, Heering, H.D., Kahn, R.R., Aarts, H., and Haren, N.E.M.

Published
2017

23. Brain GABA levels across psychiatric disorders : A systematic literature review and meta-analysis of 1H-MRS studies

Author

Schür, Remmelt R., Draisma, Luc W R, Wijnen, Jannie P., Boks, Marco P., Koevoets, Martijn G J C, Joëls, Marian, Klomp, Dennis W., Kahn, René S., and Vinkers, Christiaan H.

Subjects
MDD, 1H-MRS, Radiological and Ultrasound Technology, Clinical Neurology, Review, psychopathology, behavioral disciplines and activities, ASD, meta-analysis, GABA, Neurology, Radiology Nuclear Medicine and imaging, mental disorders, Journal Article, Anatomy
Abstract

The inhibitory gamma-aminobutyric acid (GABA) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major depressive disorder (MDD). It is therefore not surprising that proton magnetic resonance spectroscopy (1H-MRS) is increasingly used to investigate in vivo brain GABA levels. However, integration of the evidence for altered in vivo GABA levels across psychiatric disorders is lacking. We therefore systematically searched the clinical 1H-MRS literature and performed a meta-analysis. A total of 40 studies (N = 1,591) in seven different psychiatric disorders were included in the meta-analysis: MDD (N = 437), schizophrenia (N = 517), ASD (N = 150), bipolar disorder (N = 129), panic disorder (N = 81), posttraumatic stress disorder (PTSD) (N = 104), and attention deficit/hyperactivity disorder (ADHD) (N = 173). Brain GABA levels were lower in ASD (standardized mean difference [SMD] = −0.74, P = 0.001) and in depressed MDD patients (SMD = −0.52, P = 0.005), but not in remitted MDD patients (SMD = −0.24, P = 0.310) compared with controls. In schizophrenia this finding did not reach statistical significance (SMD = −0.23, P = 0.089). No significant differences in GABA levels were found in bipolar disorder, panic disorder, PTSD, and ADHD compared with controls. In conclusion, this meta-analysis provided evidence for lower brain GABA levels in ASD and in depressed (but not remitted) MDD patients compared with healthy controls. Findings in schizophrenia were more equivocal. Even though future 1H-MRS studies could greatly benefit from a longitudinal design and consensus on the preferred analytical approach, it is apparent that 1H-MRS studies have great potential in advancing our understanding of the role of the GABA system in the pathogenesis of psychiatric disorders.

Published
2016

27. Trajectories of subcortical volume change in schizophrenia: A 5-year follow-up

Author

Onderzoeksgroep 4, Brain, Onderzoek, Onderzoeksgroep 1, van Haren, Neeltje E M, Schnack, Hugo G, Koevoets, Martijn G J C, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Onderzoeksgroep 4, Brain, Onderzoek, Onderzoeksgroep 1, van Haren, Neeltje E M, Schnack, Hugo G, Koevoets, Martijn G J C, Cahn, Wiepke, Hulshoff Pol, Hilleke E, and Kahn, René S

Published
2016

28. Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of 1H-MRS studies

Author

AIOS Psychiatrie, Brain, Highfield Research Group, Infection & Immunity, Onderzoeksgroep 2, Onderzoeksgroep 4, TN groep Joëls, Regenerative Medicine and Stem Cells, Cancer, Circulatory Health, Onderzoek, Diagnostiek & Vroege Psychose Medisch, Schür, Remmelt R., Draisma, Luc W R, Wijnen, Jannie P., Boks, Marco P., Koevoets, Martijn G J C, Joëls, Marian, Klomp, Dennis W., Kahn, René S., Vinkers, Christiaan H., AIOS Psychiatrie, Brain, Highfield Research Group, Infection & Immunity, Onderzoeksgroep 2, Onderzoeksgroep 4, TN groep Joëls, Regenerative Medicine and Stem Cells, Cancer, Circulatory Health, Onderzoek, Diagnostiek & Vroege Psychose Medisch, Schür, Remmelt R., Draisma, Luc W R, Wijnen, Jannie P., Boks, Marco P., Koevoets, Martijn G J C, Joëls, Marian, Klomp, Dennis W., Kahn, René S., and Vinkers, Christiaan H.

Published
2016

29. Impaired frontal processing during agency inferences in schizophrenia

Author

Onderzoeksgroep 4, Brain, Onderzoek, Renes, Robert A., Vink, Matthijs, van der Weiden, Anouk, Prikken, Merel, Koevoets, Martijn G J C, Kahn, René S., Aarts, Henk, van Haren, Neeltje E M, Onderzoeksgroep 4, Brain, Onderzoek, Renes, Robert A., Vink, Matthijs, van der Weiden, Anouk, Prikken, Merel, Koevoets, Martijn G J C, Kahn, René S., Aarts, Henk, and van Haren, Neeltje E M

Published
2016

31. Impaired frontal processing during agency inferences in schizophrenia

Author

Renes, Robert A, Vink, Matthijs, van der Weiden, Anouk, Prikken, Merel, Koevoets, Martijn G J C, Kahn, René S, Aarts, Henk, van Haren, Neeltje E M, Renes, Robert A, Vink, Matthijs, van der Weiden, Anouk, Prikken, Merel, Koevoets, Martijn G J C, Kahn, René S, Aarts, Henk, and van Haren, Neeltje E M

Abstract

People generally experience themselves as the cause of outcomes following from their own actions. Such agency inferences occur fluently and are essential to social interaction. However, schizophrenia patients often experience difficulties in distinguishing their own actions from those of others. Building on recent research into the neural substrates underlying agency inferences in healthy individuals, the present study investigates how these inferences are represented on a neural level in patients with schizophrenia. Thirty-one schizophrenia patients and 31 healthy controls performed an agency inference task while functional magnetic resonance images were obtained. Participants were presented with a task wherein the relationship between their actions and the subsequent outcomes was ambiguous. They received instructions to cause specific outcomes to occur by pressing a key, but the task was designed to match or mismatch the color outcome with the participants' goal. Both groups experienced stronger agency when their goal matched (vs. mismatched) the outcome. However, region of interest analyses revealed that only controls showed the expected involvement of the medial prefrontal cortex and superior frontal gyrus, whereas in patients the agency experience was not related to brain activation. These findings are discussed in light of a hypofrontality model of schizophrenia.

Published
2015

32. Impaired frontal processing during agency inferences in schizophrenia

Author

Social-cognitive and interpersonal determinants of behaviour, Leerstoel Aarts, Leerstoel Ridder, Renes, Robert A, Vink, Matthijs, van der Weiden, Anouk, Prikken, Merel, Koevoets, Martijn G J C, Kahn, René S, Aarts, Henk, van Haren, Neeltje E M, Social-cognitive and interpersonal determinants of behaviour, Leerstoel Aarts, Leerstoel Ridder, Renes, Robert A, Vink, Matthijs, van der Weiden, Anouk, Prikken, Merel, Koevoets, Martijn G J C, Kahn, René S, Aarts, Henk, and van Haren, Neeltje E M

Published
2015

33. Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of 1H-MRS studies.

Author

Schür, Remmelt R., Draisma, Luc W.R., Wijnen, Jannie P., Boks, Marco P., Koevoets, Martijn G.J.C., Joëls, Marian, Klomp, Dennis W., Kahn, René S., and Vinkers, Christiaan H.

Abstract

The inhibitory gamma-aminobutyric acid (GABA) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major depressive disorder (MDD). It is therefore not surprising that proton magnetic resonance spectroscopy (1H-MRS) is increasingly used to investigate in vivo brain GABA levels. However, integration of the evidence for altered in vivo GABA levels across psychiatric disorders is lacking. We therefore systematically searched the clinical 1H-MRS literature and performed a meta-analysis. A total of 40 studies ( N = 1,591) in seven different psychiatric disorders were included in the meta-analysis: MDD ( N = 437), schizophrenia ( N = 517), ASD ( N = 150), bipolar disorder ( N = 129), panic disorder ( N = 81), posttraumatic stress disorder (PTSD) ( N = 104), and attention deficit/hyperactivity disorder (ADHD) ( N = 173). Brain GABA levels were lower in ASD ( standardized mean difference [SMD] = −0.74, P = 0.001) and in depressed MDD patients ( SMD = −0.52, P = 0.005), but not in remitted MDD patients ( SMD = −0.24, P = 0.310) compared with controls. In schizophrenia this finding did not reach statistical significance ( SMD = −0.23, P = 0.089). No significant differences in GABA levels were found in bipolar disorder, panic disorder, PTSD, and ADHD compared with controls. In conclusion, this meta-analysis provided evidence for lower brain GABA levels in ASD and in depressed (but not remitted) MDD patients compared with healthy controls. Findings in schizophrenia were more equivocal. Even though future 1H-MRS studies could greatly benefit from a longitudinal design and consensus on the preferred analytical approach, it is apparent that 1H-MRS studies have great potential in advancing our understanding of the role of the GABA system in the pathogenesis of psychiatric disorders. Hum Brain Mapp 37:3337-3352, 2016. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2016
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34. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

Van Den Heuvel, Martijn P, Scholtens, Lianne H, Van Der Burgh, Hannelore K, Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon JNL, Beyer, Frauke, Booij, Linda, Braun, Kees PJ, Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M, Chaim-Avancini, Tiffany M, Chan, Sandra SM, Chen, Eric YH, Crespo-Facorro, Benedicto, Crone, Eveline A, Dannlowski, Udo, De Zwarte, Sonja MC, Dietsche, Bruno, Donohoe, Gary, Plessis, Stefan Du, Durston, Sarah, Díaz-Caneja, Covadonga M, Díaz-Zuluaga, Ana M, Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M, Holleran, Laurena, Holt, Rosemary, Hopman, Helene J, Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn GJC, Kostic, Vladimir S, Krug, Axel, Lawrie, Stephen M, Lebedeva, Irina S, Lee, Edwin HM, Lett, Tristram A, Lewis, Simon JG, Liem, Franziskus, Lombardo, Michael V, Lopez-Jaramillo, Carlos, Margulies, Daniel S, Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M, McPhilemy, Genevieve, Meinert, Susanne L, Menchón, José M, Montag, Christian, Moreira, Pedro S, Morgado, Pedro, Mothersill, David O, Mérillat, Susan, Müller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia De La Foz, Victor, Peper, Jiska S, Pineda, Julian A, Rasser, Paul E, Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro GP, Ruigrok, Amber NV, Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S, Tordesillas-Gutierrez, Diana, Valk, Sofie L, Van Den Berg, Leonard H, Van Erp, Theo GM, Van Haren, Neeltje EM, Van Leeuwen, Judith MC, Villringer, Arno, Vinkers, Christiaan H, Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C, Witkowska, Marta, Witte, A Veronica, Zanetti, Marcus V, Zhang, Rui, and De Lange, Siemon C

Subjects
connectome analysis, diffusion weighted MRI, brain, network, 3. Good health, MRI
Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.

35. Dynamics of Brain Structure and its Genetic Architecture over the Lifespan

Author

Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S., Loohuis, Loes M. Olde, Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E. L., Bülow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, Mol, Casper L. de, Zwarte, Sonja M. C. de, Desrivières, Sylvane, Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K. M., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, René C. W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A., Mühleisen, Thomas W., Nabulsi, Leila, Opel, Nils, Ortiz-García de la Foz, Víctor, Overs, Bronwyn J., Paillère Martinot, Marie-Laure, Quinlan, Erin B., Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V., Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E. M., Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zugman, Andre, Armstrong, Nicola J., Bralten, Janita, Dalvie, Shareefa, Forti, Marta Di, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Gonzalez-Peñas, Javier, Guimaraes, Joao P. O. F. T., Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J., Kwok, John B. J., Hellard, Stephanie Le, Mather, Karen A., Milaneschi, Yuri, Morris, Derek W., Nöthen, Markus M., Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L., Steen, Vidar M., Stein, Jason L., Streit, Fabian, Tankard, Rick M., Teumer, Alexander, van ’t Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H., Adams, Hieab H. H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A., Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L. W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Buitelaar, Jan K., Cahn, Wiepke, Caspers, Svenja, Cichon, Sven, Facorro, Benedicto Crespo, Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter G., Fisher, Simon E., Flor, Herta, Fullerton, Janice M., Garavan, Hugh, Gowland, Penny A., Grabe, Hans J., Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J., Ikram, Mohammad A., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Korgaonkar, Mayuresh S., Krug, Axel, Lemaitre, Herve, Malt, Ulrik F., Martinot, Jean-Luc, McDonald, Colm, Mitchell, Philip B., Muetzel, Ryan L., Murray, Robin M., Nees, Frauke, Nenadic, Igor, Oosterlaan, Jaap, Ophoff, Roel A., Pan, Pedro M., Penninx, Brenda W. J. H., Poustka, Luise, Sachdev, Perminder S., Salum, Giovanni A., Schofield, Peter R., Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N., Stein, Dan J., Trollor, Julian, van den Berg, Leonard H., Veldink, Jan H., Walter, Henrik, Westlye, Lars T., Whelan, Robert, White, Tonya, Wright, Margaret J., Medland, Sarah E., Franke, Barbara, Thompson, Paul M., and Pol, Hilleke E. Hulshoff

Subjects
ddc:570
Abstract

Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. While heritable, specific loci in the genome that influence these rates are largely unknown. Here, we sought to find common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association analysis of longitudinal changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 10,163 individuals aged 4 to 99 years, on average 3.5 years apart, were used to compute rates of morphological change for 15 brain structures. We discovered 5 genome-wide significant loci and 15 genes associated with brain structural changes. Most individual variants exerted age-dependent effects. All identified genes are expressed in fetal and adult brain tissue, and some exhibit developmentally regulated expression across the lifespan. We demonstrate genetic overlap with depression, schizophrenia, cognitive functioning, height, body mass index and smoking. Several of the discovered loci are implicated in early brain development and point to involvement of metabolic processes. Gene-set findings also implicate immune processes in the rates of brain changes. Taken together, in the world’s largest longitudinal imaging genetics dataset we identified genetic variants that alter age-dependent brain growth and atrophy throughout our lives. One-sentence summary We identified common genetic variants associated with the rate of brain development and aging, in longitudinal MRI scans worldwide.

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36. Dynamics of Brain Structure and its Genetic Architecture over the Lifespan

Author

Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S, Olde Loohuis, Loes M., Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alnaes, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E.L., Bülow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, de Mol, Casper L., de Zwarte, Sonja M.C., Desrivières, Sylvane, Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K.M., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianya, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, Rene C.W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A., Mühleisen, Thomas W., Nabulsi, Leila, Opel, Nils, Ortiz-García de la Foz, Victor, Overs, Bronwyn J., Paillère Martinot, Marie Laure, Quinlan, Erin B., Redlich, Ronny, Reis Marques, Tiago, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V., Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E.M., Wen, Wei, Westeneng, Henk-Jan, Wittfield, Katharina, Zugman, Andre, Armstrong, Nicola J., Bralten, Janita, Dalvie, Shareefa, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Gonzalez-Peñas, Javier, Guimaraes, Joao P. O. F. T., Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J., Kwok, John B.J., Le Hellard, Stephanie, Mather, Karen A., Milaneschi, Yuri, Morris, Derek W., Nöthen, Markus M., Papiol, Sergi, Rietsche, Marcella, Santoro, Marcus L., Steen, Vidar M., Stein, Jason L., Streit, Fabian, Tankard, Rick M., Teumer, Alexander, van't Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H., Alzheimer's Disease Neuroimaging Initiative, Adams, Hieab H.H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A., Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L.W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Buitelaar, Jan K., Cahn, Wiepke, Caspers, Svenja, Cichon, Sven, Crespo Facorro, Benedicto, Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter G., Fisher, Simon E., Flor, Herta, Fullerton, Janice M., Garavan, Hugh, Gowland, Penny A., Grabe, Hans J., Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J., Ikram, Mohammad A., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Korgaonkar, Mayuresh S., Krug, Axel, Lemaitre, Herve, Malt, Ulrik F., Martinot, Jean-Luc, McDonald, Colm, Mitchell, Philip B., Muetzel, Ryan L., Murray, Robin M., Nees, Frauke, Nenadic, Igor, Oosterlaan, Jaap, Ophoff, Roel A., Pan, Pedro M., Penninx, Brenda W.J.H., Poustka, Luise, Sachdev, Perminder S., Salum, Giovanni A., Schofield, Peter R., Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N., Stein, Dan J., Trollor, Julian, van den Berg, Leonard H., Veldink, Jan H., Walter, Henrik, Westlye, Lars T., Whelan, Robert, White, Tonya, Wright, Margaret J., Medland, Sarah E., Franke, Barbara, Thompson, Paul M., and Hulshoff Pol, Hilleke E

Subjects
3. Good health
Abstract

The results leading to this publication have received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. Any views expressed are those of the author(s) and not necessarily those of the funders.

37. Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of (1) H-MRS studies.

Author

Schür RR, Draisma LW, Wijnen JP, Boks MP, Koevoets MG, Joëls M, Klomp DW, Kahn RS, and Vinkers CH

Subjects
Humans, Proton Magnetic Resonance Spectroscopy methods, Brain metabolism, Mental Disorders metabolism, gamma-Aminobutyric Acid biosynthesis
Abstract

The inhibitory gamma-aminobutyric acid (GABA) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major depressive disorder (MDD). It is therefore not surprising that proton magnetic resonance spectroscopy ((1) H-MRS) is increasingly used to investigate in vivo brain GABA levels. However, integration of the evidence for altered in vivo GABA levels across psychiatric disorders is lacking. We therefore systematically searched the clinical (1) H-MRS literature and performed a meta-analysis. A total of 40 studies (N = 1,591) in seven different psychiatric disorders were included in the meta-analysis: MDD (N = 437), schizophrenia (N = 517), ASD (N = 150), bipolar disorder (N = 129), panic disorder (N = 81), posttraumatic stress disorder (PTSD) (N = 104), and attention deficit/hyperactivity disorder (ADHD) (N = 173). Brain GABA levels were lower in ASD (standardized mean difference [SMD] = -0.74, P = 0.001) and in depressed MDD patients (SMD = -0.52, P = 0.005), but not in remitted MDD patients (SMD = -0.24, P = 0.310) compared with controls. In schizophrenia this finding did not reach statistical significance (SMD = -0.23, P = 0.089). No significant differences in GABA levels were found in bipolar disorder, panic disorder, PTSD, and ADHD compared with controls. In conclusion, this meta-analysis provided evidence for lower brain GABA levels in ASD and in depressed (but not remitted) MDD patients compared with healthy controls. Findings in schizophrenia were more equivocal. Even though future (1) H-MRS studies could greatly benefit from a longitudinal design and consensus on the preferred analytical approach, it is apparent that (1) H-MRS studies have great potential in advancing our understanding of the role of the GABA system in the pathogenesis of psychiatric disorders. Hum Brain Mapp 37:3337-3352, 2016. © 2016 Wiley Periodicals, Inc., (© 2016 Wiley Periodicals, Inc.)

Published
2016
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