Search

Your search keyword '"Koepler, O."' showing total 11 results
Start Over Author "Koepler, O."
11 results on '"Koepler, O."'

1. Knowledge Annotation within Research Data Management System for Oxygen-Free Production Technologies

Author

Mozgova, I., Altun, O., Sheveleva, T., Castro, A., Oladazimi, P., Koepler, O., Lachmayer, R., and Auer, S.

Subjects
design support system, Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau, research data management, ddc:620, FAIR data principles, knowledge management, Konferenzschrift, semantic modelling
Abstract

The comprehensive implementation of digital technologies in product manufacturing leads to changes in engineering processes and requires new approaches to data management. An important role belongs to the processes of organizing the collection, storage and reuse of research data obtained and used in the process of product, system or technology development, taking into account the FAIR data principles. This article describes a Research Data Management System for the organization of documentation and measurement requests in the research and development of new oxygen-free production technologies.

Published
2022

2. NFDI4Chem - Towards a national research data infrastructure for chemistry in Germany

Author

Steinbeck, C., Koepler, O., Bach, F., Herres-Pawlis, S., Jung, N., Liermann, J.C., Neumann, S., Razum, M., Baldauf, C., Biedermann, F., Bocklitz, T.W., Boehm, F., Broda, F., Czodrowski, P., Engel, T., Hicks, M.G., Kast, S.M., Kettner, C., Koch, W., Lanza, G., Link, A., Mata, R.A., Nagel, W.E., Porzel, A., Schlörer, N., Schulze, Tobias, Weinig, H.-G., Wenzel, W., Wessjohann, L.A., Wulle, S., Steinbeck, C., Koepler, O., Bach, F., Herres-Pawlis, S., Jung, N., Liermann, J.C., Neumann, S., Razum, M., Baldauf, C., Biedermann, F., Bocklitz, T.W., Boehm, F., Broda, F., Czodrowski, P., Engel, T., Hicks, M.G., Kast, S.M., Kettner, C., Koch, W., Lanza, G., Link, A., Mata, R.A., Nagel, W.E., Porzel, A., Schlörer, N., Schulze, Tobias, Weinig, H.-G., Wenzel, W., Wessjohann, L.A., and Wulle, S.

Abstract

The vision of NFDI4Chem is the digitalisation of all key steps in chemical research to support scientists in their efforts to collect, store, process, analyse, disclose and re-use research data. Measures to promote Open Science and Research Data Management (RDM) in agreement with the FAIR data principles are fundamental aims of NFDI4Chem to serve the chemistry community with a holistic concept for access to research data. To this end, the overarching objective is the development and maintenance of a national research data infrastructure for the research domain of chemistry in Germany, and to enable innovative and easy to use services and novel scientific approaches based on re-use of research data. NFDI4Chem intends to represent all disciplines of chemistry in academia. We aim to collaborate closely with thematically related consortia. In the initial phase, NFDI4Chem focuses on data related to molecules and reactions including data for their experimental and theoretical characterisation. This overarching goal is achieved by working towards a number of key objectives: Key Objective 1: Establish a virtual environment of federated repositories for storing, disclosing, searching and re-using research data across distributed data sources. Connect existing data repositories and, based on a requirements analysis, establish domain-specific research data repositories for the national research community, and link them to international repositories. Key Objective 2: Initiate international community processes to establish minimum information (MI) standards for data and machine-readable metadata as well as open data standards in key areas of chemistry. Identify and recommend open data standards in key areas of chemistry, in order to support the FAIR principles for research data. Finally, develop standards, if there is a lack. Key Objective 3: Foster cultural and digital change towards Smart Laboratory Environments by promoting the use of digital tools in all stages of research a

Published
2020

4. Berlin Declaration on NFDI Cross-Cutting Topics. Zenodo. Version 1.0

Author

Glöckner, F.O., Diepenbroek, M., Felden, J., Overmann, J., Bonn, Aletta ; orcid:0000-0002-8345-4600, Gemeinholzer, B., Güntsch, A., König-Ries, B., Seeger, B., Pollex-Krüger, A., Fluck, J., Pigeot, I., Kirsten, T., Mühlhaus, T., Wolf, C., Heinrich, U., Steinbeck, C., Koepler, O., Stegle, O., Weimann, J., Schörner-Sadenius, T., Gutt, C., Stahl, F., Wagemann, K., Schrade, T., Schmitt, R., Eberl, C., Gauterin, F., Schultz, M., Bernard, L., Glöckner, F.O., Diepenbroek, M., Felden, J., Overmann, J., Bonn, Aletta ; orcid:0000-0002-8345-4600, Gemeinholzer, B., Güntsch, A., König-Ries, B., Seeger, B., Pollex-Krüger, A., Fluck, J., Pigeot, I., Kirsten, T., Mühlhaus, T., Wolf, C., Heinrich, U., Steinbeck, C., Koepler, O., Stegle, O., Weimann, J., Schörner-Sadenius, T., Gutt, C., Stahl, F., Wagemann, K., Schrade, T., Schmitt, R., Eberl, C., Gauterin, F., Schultz, M., and Bernard, L.

Abstract

In the spirit of our common interest to build what could become an international beacon for sharing the benefits of high-quality research data and research data management, the signing NFDI consortia strongly support the idea that NFDI must build on a coordinated and inclusive effort fostering the FAIR data principles. Recalling the challenges that interoperability and sharing of data faces, the 21 consortia signing this declaration agreed on a common list of cross-cutting topics.

Published
2019

5. Berlin Declaration on NFDI Cross-Cutting Topics (Version 1)

Author

Glöckner, F.O., Diepenbroek, M., Felden, J., Overmann, J., Bonn, Aletta, Gemeinholzer, B., Güntsch, A., König-Ries, B., Seeger, B., Pollex-Krüger, A., Fluck, J., Pigeot, I., Kirsten, T., Mühlhaus, T., Wolf, C., Heinrich, U., Steinbeck, C., Koepler, O., Stegle, O., Weimann, J., Schörner-Sadenius, T., Gutt, C., Stahl, F., Wagemann, K., Schrade, T., Schmitt, R., Eberl, C., Gauterin, F., Schultz, M., Bernard, L., Glöckner, F.O., Diepenbroek, M., Felden, J., Overmann, J., Bonn, Aletta, Gemeinholzer, B., Güntsch, A., König-Ries, B., Seeger, B., Pollex-Krüger, A., Fluck, J., Pigeot, I., Kirsten, T., Mühlhaus, T., Wolf, C., Heinrich, U., Steinbeck, C., Koepler, O., Stegle, O., Weimann, J., Schörner-Sadenius, T., Gutt, C., Stahl, F., Wagemann, K., Schrade, T., Schmitt, R., Eberl, C., Gauterin, F., Schultz, M., and Bernard, L.

Abstract

In the spirit of our common interest to build what could become an international beacon for sharing the benefits of high-quality research data and research data management, the signing NFDI consortia strongly support the idea that NFDI must build on a coordinated and inclusive effort fostering the FAIR data principles. Recalling the challenges that interoperability and sharing of data faces, the 21 consortia signing this declaration agreed on a common list of cross-cutting topics.

Published
2019

9. Minimum Information Standards in Chemistry: A Call for Better Research Data Management Practices.

Author

Herres-Pawlis S, Bach F, Bruno IJ, Chalk SJ, Jung N, Liermann JC, McEwen LR, Neumann S, Steinbeck C, Razum M, and Koepler O

Subjects
Data Management, Laboratories
Abstract

Research data management (RDM) is needed to assist experimental advances and data collection in the chemical sciences. Many funders require RDM because experiments are often paid for by taxpayers and the resulting data should be deposited sustainably for posterity. However, paper notebooks are still common in laboratories and research data is often stored in proprietary and/or dead-end file formats without experimental context. Data must mature beyond a mere supplement to a research paper. Electronic lab notebooks (ELN) and laboratory information management systems (LIMS) allow researchers to manage data better and they simplify research and publication. Thus, an agreement is needed on minimum information standards for data handling to support structured approaches to data reporting. As digitalization becomes part of curricular teaching, future generations of digital native chemists will embrace RDM and ELN as an organic part of their research., (© 2022 Wiley-VCH GmbH.)

Published
2022
Full Text
View/download PDF

10. NFDI4Chem: Shaping a Digital and Cultural Change in Chemistry.

Author

Herres-Pawlis S, Koepler O, and Steinbeck C

Abstract

"The formation of a National Research Data Infrastructure for Chemistry (NFDI4Chem), integrated into a National Research Data Infrastructure for all scientific disciplines, is a great opportunity for our discipline. Proper research data management is the basis for good scientific practice and opens up new fields of research …" Read more in the Guest Editorial by S. Herres-Pawlis et al., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2019
Full Text
View/download PDF

11. Synthesis and DNA binding properties of novel benzo[b]isoquino[2,3-h]-naphthyridines.

Author

Koepler O, Mazzini S, Bellucci MC, Mondelli R, Baro A, Laschat S, Hotfilder M, Viseur C, and Frey W

Subjects
Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Models, Molecular, Naphthyridines pharmacology, Spectrometry, Mass, Electrospray Ionization, DNA chemistry, Naphthyridines chemical synthesis, Naphthyridines chemistry
Abstract

Several benzo[b]isoquino[2,3-h]-naphthyridines have been prepared via formal hetero-Diels Alder reaction of N-aryl imines as a key step. These compounds have different side chains at C-11, and a cis or trans configuration at the C-8a,C-14a ring junction. Binding constants for the interaction with oligonucleotides and polynucleotides were determined by UV absorption and melting experiments. NMR experiments (NOE) revealed that the cis isomers, showing a slightly folded structure, preferentially bind to the minor groove of AT-rich oligomers. In contrast, the trans isomers prefer the CG-rich sequences, leading to cap-complexes with the isoquinoline moiety stacked at the top of the double helix, in agreement with the flatter shape, and with a preference for the 3'-terminals, as found for camptothecins. Models of the complexes were built up by molecular dynamics (MD) calculations, by using the inter-proton distances derived from the NOE values. Cytotoxicity assays against human Ewing sarcoma cell lines RD-ES and CAD-ES1 were performed.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results