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2. Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Author

Wang, Liewei, Scherer, Steven E., Bielinski, Suzette J., Muzny, Donna M., Jones, Leila A., Black, John Logan, III, Moyer, Ann M., Giri, Jyothsna, Sharp, Richard R., Matey, Eric T., Wright, Jessica A., Oyen, Lance J., Nicholson, Wayne T., Wiepert, Mathieu, Sullard, Terri, Curry, Timothy B., Rohrer Vitek, Carolyn R., McAllister, Tammy M., St. Sauver, Jennifer L., Caraballo, Pedro J., Lazaridis, Konstantinos N., Venner, Eric, Qin, Xiang, Hu, Jianhong, Kovar, Christie L., Korchina, Viktoriya, Walker, Kimberly, Doddapaneni, HarshaVardhan, Wu, Tsung-Jung, Raj, Ritika, Denson, Shawn, Liu, Wen, Chandanavelli, Gauthami, Zhang, Lan, Wang, Qiaoyan, Kalra, Divya, Karow, Mary Beth, Harris, Kimberley J., Sicotte, Hugues, Peterson, Sandra E., Barthel, Amy E., Moore, Brenda E., Skierka, Jennifer M., Kluge, Michelle L., Kotzer, Katrina E., Kloke, Karen, Vander Pol, Jessica M., Marker, Heather, Sutton, Joseph A., Kekic, Adrijana, Ebenhoh, Ashley, Bierle, Dennis M., Schuh, Michael J., Grilli, Christopher, Erickson, Sara, Umbreit, Audrey, Ward, Leah, Crosby, Sheena, Nelson, Eric A., Levey, Sharon, Elliott, Michelle, Peters, Steve G., Pereira, Naveen, Frye, Mark, Shamoun, Fadi, Goetz, Matthew P., Kullo, Iftikhar J., Wermers, Robert, Anderson, Jan A., Formea, Christine M., El Melik, Razan M., Zeuli, John D., Herges, Joseph R., Krieger, Carrie A., Hoel, Robert W., Taraba, Jodi L., St. Thomas, Scott R., Absah, Imad, Bernard, Matthew E., Fink, Stephanie R., Gossard, Andrea, Grubbs, Pamela L., Jacobson, Therese M., Takahashi, Paul, Zehe, Sharon C., Buckles, Susan, Bumgardner, Michelle, Gallagher, Colette, Fee-Schroeder, Kelliann, Nicholas, Nichole R., Powers, Melody L., Ragab, Ahmed K., Richardson, Darcy M., Stai, Anthony, Wilson, Jaymi, Pacyna, Joel E., Olson, Janet E., Sutton, Erica J., Beck, Annika T., Horrow, Caroline, Kalari, Krishna R., Larson, Nicholas B., Liu, Hongfang, Wang, Liwei, Lopes, Guilherme S., Borah, Bijan J., Freimuth, Robert R., Zhu, Ye, Jacobson, Debra J., Hathcock, Matthew A., Armasu, Sebastian M., McGree, Michaela E., Jiang, Ruoxiang, Koep, Tyler H., Ross, Jason L., Hilden, Matthew G., Bosse, Kathleen, Ramey, Bronwyn, Searcy, Isabelle, Boerwinkle, Eric, Gibbs, Richard A., and Weinshilboum, Richard M.

Published
2022
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4. Integrating pharmacogenomics panel testing for supportive care medications in patients with solid tumors.

Author

Kekic, Adrijana, primary, Seetharam, Mahesh, additional, Singh, Parminder, additional, Kunze, Katie, additional, Golafshar, Michael A, additional, Azevedo, Cindy, additional, Welp, Sydney, additional, Bofferding, Anne, additional, Koep, Tyler, additional, Ross, Jason, additional, Nelson, Eric, additional, Grilli, Christopher, additional, and Samadder, Jewel, additional

Published
2020
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5. Supplemental Material, OneOme_sample_comprehensive_report - Feasibility of Integrating Panel-Based Pharmacogenomics Testing for Chemotherapy and Supportive Care in Patients With Colorectal Cancer

Author

Pashtoon Murtaza Kasi, Koep, Tyler, Schnettler, Erica, Shahjehan, Faisal, Vaishnavi Kamatham, Baldeo, Candice, and Hughes, Caren L.

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, Biochemistry, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental Material, OneOme_sample_comprehensive_report for Feasibility of Integrating Panel-Based Pharmacogenomics Testing for Chemotherapy and Supportive Care in Patients With Colorectal Cancer by Pashtoon Murtaza Kasi, Tyler Koep, Erica Schnettler, Faisal Shahjehan, Vaishnavi Kamatham, Candice Baldeo and Caren L. Hughes in Technology in Cancer Research & Treatment

Published
2019
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6. Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools

Author

Koep Tyler H, Enders Felicity T, Pierret Chris, Ekker Stephen C, Krageschmidt Dale, Neff Kevin L, Lipsitch Marc, Shaman Jeffrey, and Huskins W Charles

Subjects
Influenza, Humidity, Schools, Climate, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks. Humidification of indoor environments may mitigate viral transmission and may be an important control strategy, particularly in schools where viral transmission is common and contributes to the spread of influenza in communities. However, the variability and predictors of AH in the indoor school environment and the feasibility of classroom humidification to levels that could decrease viral survival have not been studied. Methods Automated sensors were used to measure temperature, humidity and CO2 levels in two Minnesota grade schools without central humidification during two successive winters. Outdoor AH measurements were derived from the North American Land Data Assimilation System. Variability in indoor AH within classrooms, between classrooms in the same school, and between schools was assessed using concordance correlation coefficients (CCC). Predictors of indoor AH were examined using time-series Auto-Regressive Conditional Heteroskedasticity models. Classroom humidifiers were used when school was not in session to assess the feasibility of increasing indoor AH to levels associated with decreased influenza virus survival, as projected from previously published animal experiments. Results AH varied little within classrooms (CCC >0.90) but was more variable between classrooms in the same school (CCC 0.81 for School 1, 0.88 for School 2) and between schools (CCC 0.81). Indoor AH varied widely during the winter (range 2.60 to 10.34 millibars [mb]) and was strongly associated with changes in outdoor AH (p 2 levels (p Conclusions During winter, indoor AH in non-humidified grade schools varies substantially and often to levels that are very low. Indoor results are predicted by outdoor AH over a season and CO2 levels (which likely reflects human activity) during individual school days. Classroom humidification may be a feasible approach to increase indoor AH to levels that may decrease influenza virus survival and transmission.

Published
2013
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7. Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol)

Author

Bielinski, Suzette J, primary, St Sauver, Jennifer L, primary, Olson, Janet E, primary, Larson, Nicholas B, primary, Black, John L, primary, Scherer, Steven E, primary, Bernard, Matthew E, primary, Boerwinkle, Eric, primary, Borah, Bijan J, primary, Caraballo, Pedro J, primary, Curry, Timothy B, primary, Doddapaneni, HarshaVardhan, primary, Formea, Christine M, primary, Freimuth, Robert R, primary, Gibbs, Richard A, primary, Giri, Jyothsna, primary, Hathcock, Matthew A, primary, Hu, Jianhong, primary, Jacobson, Debra J, primary, Jones, Leila A, primary, Kalla, Sara, primary, Koep, Tyler H, primary, Korchina, Viktoriya, primary, Kovar, Christie L, primary, Lee, Sandra, primary, Liu, Hongfang, primary, Matey, Eric T, primary, McGree, Michaela E, primary, McAllister, Tammy M, primary, Moyer, Ann M, primary, Muzny, Donna M, primary, Nicholson, Wayne T, primary, Oyen, Lance J, primary, Qin, Xiang, primary, Raj, Ritika, primary, Roger, Véronique L, primary, Rohrer Vitek, Carolyn R, primary, Ross, Jason L, primary, Sharp, Richard R, primary, Takahashi, Paul Y, primary, Venner, Eric, primary, Walker, Kimberly, primary, Wang, Liwei, primary, Wang, Qiaoyan, primary, Wright, Jessica A, primary, Wu, Tsung-Jung, primary, Wang, Liewei, primary, and Weinshilboum, Richard M, primary

Published
2019
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11. Humidity as a non-pharmaceutical intervention for influenza A

Author

Reiman, Jennifer M., primary, Das, Biswadeep, additional, Sindberg, Gregory M., additional, Urban, Mark D., additional, Hammerlund, Madeleine E. M., additional, Lee, Han B., additional, Spring, Katie M., additional, Lyman-Gingerich, Jamie, additional, Generous, Alex R., additional, Koep, Tyler H., additional, Ewing, Kevin, additional, Lilja, Phil, additional, Enders, Felicity T., additional, Ekker, Stephen C., additional, Huskins, W. Charles, additional, Fadel, Hind J., additional, and Pierret, Chris, additional

Published
2018
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14. Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools

Author

Koep, Tyler H., Enders, Felicity T., Pierret, Chris, Ekker, Stephen C., Krageschmidt, Dale, Neff, Kevin L., Lipsitch, Marc, Shaman, Jeffrey L., and Huskins, W. Charles

Subjects
Environmental health, 13. Climate action, education, Medical sciences
Abstract

Background: Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks. Humidification of indoor environments may mitigate viral transmission and may be an important control strategy, particularly in schools where viral transmission is common and contributes to the spread of influenza in communities. However, the variability and predictors of AH in the indoor school environment and the feasibility of classroom humidification to levels that could decrease viral survival have not been studied. Methods: Automated sensors were used to measure temperature, humidity and CO2 levels in two Minnesota grade schools without central humidification during two successive winters. Outdoor AH measurements were derived from the North American Land Data Assimilation System. Variability in indoor AH within classrooms, between classrooms in the same school, and between schools was assessed using concordance correlation coefficients (CCC). Predictors of indoor AH were examined using time-series Auto-Regressive Conditional Heteroskedasticity models. Classroom humidifiers were used when school was not in session to assess the feasibility of increasing indoor AH to levels associated with decreased influenza virus survival, as projected from previously published animal experiments. Results: AH varied little within classrooms (CCC >0.90) but was more variable between classrooms in the same school (CCC 0.81 for School 1, 0.88 for School 2) and between schools (CCC 0.81). Indoor AH varied widely during the winter (range 2.60 to 10.34 millibars [mb]) and was strongly associated with changes in outdoor AH (p

15. Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol).

Author

Bielinski SJ, St Sauver JL, Olson JE, Larson NB, Black JL, Scherer SE, Bernard ME, Boerwinkle E, Borah BJ, Caraballo PJ, Curry TB, Doddapaneni H, Formea CM, Freimuth RR, Gibbs RA, Giri J, Hathcock MA, Hu J, Jacobson DJ, Jones LA, Kalla S, Koep TH, Korchina V, Kovar CL, Lee S, Liu H, Matey ET, McGree ME, McAllister TM, Moyer AM, Muzny DM, Nicholson WT, Oyen LJ, Qin X, Raj R, Roger VL, Rohrer Vitek CR, Ross JL, Sharp RR, Takahashi PY, Venner E, Walker K, Wang L, Wang Q, Wright JA, Wu TJ, Wang L, and Weinshilboum RM

Subjects
Cohort Studies, Female, Humans, Male, Precision Medicine, Clinical Protocols, Genomics, Pharmacogenetics
Published
2020
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