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Your search keyword '"Koenig, Thorsten"' showing total 11 results
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11 results on '"Koenig, Thorsten"'

2. Temporal autoregulation during human PU.1 locus SubTAD formation

Author

Schuetzmann, Daniel, Walter, Carolin, van Riel, Boet, Kruse, Sabrina, König, Thorsten, Erdmann, Tabea, Tönges, Alexander, Bindels, Eric, Weilemann, Andre, Gebhard, Claudia, Wethmar, Klaus, Perrod, Chiara, Minderjahn, Julia, Rehli, Michael, Delwel, Ruud, Lenz, Georg, Gröschel, Stefan, Dugas, Martin, and Rosenbauer, Frank

Published
2018
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4. Dexamethasone‐mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells

Author

Ahmed, Helal Mohammed Mohammed, primary, Nimmagadda, Subbaiah Chary, additional, Al‐Matary, Yahya S., additional, Fiori, Maren, additional, May, Tobias, additional, Frank, Daria, additional, Patnana, Pradeep Kumar, additional, Récher, Christian, additional, Schliemann, Christoph, additional, Mikesch, Jan‐Henrik, additional, Koenig, Thorsten, additional, Rosenbauer, Frank, additional, Hartmann, Wolfgang, additional, Tuckermann, Jan, additional, Dührsen, Ulrich, additional, Lanying, Wei, additional, Dugas, Martin, additional, Opalka, Bertram, additional, Lenz, Georg, additional, and Khandanpour, Cyrus, additional

Published
2021
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6. AML Associated Mesenchymal Stroma Cells Support Growth of AML Cells As a Result of Activated Notch Signaling and This Can be Targeted By Dexamethasone

Author

Ahmed, Helal Mohammed Mohammed Ahmed, primary, Al-Matary, Yahya Saleh, additional, Nimmagadda, Subbaiah Chary, additional, Fiori, Maren, additional, Patnana, Pradeep Kumar, additional, Frank, Daria, additional, Wei, Lanying, additional, Schütte, Judith, additional, May, Tobias, additional, Goethert, Joachim R., additional, Schroeder, Thomas, additional, Buttkereit, Ulrike, additional, Recher, Christian, additional, Rodríguez-Paredes, Manuel, additional, Koenig, Thorsten, additional, Hartmann, Wolfgang, additional, Tuckermann, Jan, additional, Opalka, Bertram, additional, Lenz, Georg, additional, and Khandanpour, Cyrus, additional

Published
2020
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7. Dexamethasone‐mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells.

Author

Ahmed, Helal Mohammed Mohammed, Nimmagadda, Subbaiah Chary, Al‐Matary, Yahya S., Fiori, Maren, May, Tobias, Frank, Daria, Patnana, Pradeep Kumar, Récher, Christian, Schliemann, Christoph, Mikesch, Jan‐Henrik, Koenig, Thorsten, Rosenbauer, Frank, Hartmann, Wolfgang, Tuckermann, Jan, Dührsen, Ulrich, Lanying, Wei, Dugas, Martin, Opalka, Bertram, Lenz, Georg, and Khandanpour, Cyrus

Subjects
MESENCHYMAL stem cells, STROMAL cells, DEXAMETHASONE, ACUTE myeloid leukemia, LEUKEMIA
Abstract

Summary: Acute myeloid leukaemia (AML) is a haematological malignancy characterized by a poor prognosis. Bone marrow mesenchymal stromal cells (BM MSCs) support leukaemic cells in preventing chemotherapy‐induced apoptosis. This encouraged us to investigate leukaemia‐BM niche‐associated signalling and to identify signalling cascades supporting the interaction of leukaemic cells and BM MSC. Our study demonstrated functional differences between MSCs originating from leukaemic (AML MSCs) and healthy donors (HD MSCs). The direct interaction of leukaemic and AML MSCs was indispensable in influencing AML cell proliferation. We further identified an important role for Notch expression and its activation in AML MSCs contributing to the enhanced proliferation of AML cells. Supporting this observation, overexpression of the intracellular Notch domain (Notch ICN) in AML MSCs enhanced AML cells' proliferation. From a therapeutic point of view, dexamethasone treatment impeded Notch signalling in AML MSCs resulting in reduced AML cell proliferation. Concurrent with our data, Notch inhibitors had only a marginal effect on leukaemic cells alone but strongly influenced Notch signalling in AML MSCs and abrogated their cytoprotective function on AML cells. In vivo, dexamethasone treatment impeded Notch signalling in AML MSCs leading to a reduced number of AML MSCs and improved survival of leukaemic mice. In summary, targeting the interaction of leukaemic cells and AML MSCs using dexamethasone or Notch inhibitors might further improve treatment outcomes in AML patients. [ABSTRACT FROM AUTHOR]

Published
2022
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