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3. Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Zeng, Xiankun, additional, Reyes, Leticia, additional, Simmons, Heather A., additional, Morgan, Terry K., additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Schmidt, Jenna A., additional, Ren, Emily, additional, Leyva Jaimes, Fernanda B., additional, Winston, Eva, additional, Basu, Puja, additional, Weiler, Andrea M., additional, Friedrich, Thomas C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2023
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5. Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Simmons, Heather A., additional, Mejia, Andres, additional, Leyva Jaimes, Fernanda, additional, Keding, Logan T., additional, Crooks, Chelsea M., additional, Weiler, Andrea M., additional, Bohm, Ellie K., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2023
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6. Fetal Tissues Reflect Decidual-Placental Inflammation

Author

Vazquez, Jessica, primary, Keding, Logan, additional, Koenig, Michelle R, additional, Schotzko, Michele, additional, Antony, Kathleen, additional, Racine, Jenna, additional, Simmons, Heather A, additional, Shah, Dinesh M, additional, Wieben, Oliver, additional, and Golos, Thaddeus, additional

Published
2023
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7. Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

Author

Dudley, Dawn M., primary, Koenig, Michelle R., additional, Stewart, Laurel M., additional, Semler, Matthew R., additional, Newman, Christina M., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Breitbach, Meghan E., additional, Schotzko, Michele, additional, Kohn, Sarah, additional, Antony, Kathleen M., additional, Qiu, Hongyu, additional, Tunga, Priyadarshini, additional, Anderson, Deborah M., additional, Guo, Wendi, additional, Dennis, Maria, additional, Singh, Tulika, additional, Rybarczyk, Sierra, additional, Weiler, Andrea M., additional, Razo, Elaina, additional, Mitzey, Ann, additional, Zeng, Xiankun, additional, Eickhoff, Jens C., additional, Mohr, Emma L., additional, Simmons, Heather A., additional, Fritsch, Michael K., additional, Mejia, Andres, additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, Kodihalli, Shantha, additional, Permar, Sallie R., additional, and O’Connor, David H., additional

Published
2022
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8. Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Simmons, Heather A., additional, Mejia, Andres, additional, Jaimes, Fernanda Leyva, additional, Keding, Logan T., additional, Crooks, Chelsea M., additional, Weiler, Andrea M., additional, Bohm, Ellie K., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2022
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9. #20: Modeling Zika virus tissue tropism in rhesus macaques to define the risk of donor derived transmission

Author

Treadway, Taylor A, primary, Shepherd, Phoenix M, additional, Newman, Christina M, additional, Mohr, Emma L, additional, Dudley, Dawn M, additional, Breitbach, Meghan E, additional, Yamamoto, Keisuke, additional, Stewart, Laurel M, additional, Koenig, Michelle R, additional, Bliss, Mason, additional, Rybarczyk, Sierra L, additional, Weiler, Andrea M, additional, Semler, Matthew R, additional, Mitzey, Ann, additional, Razo, Elaina, additional, Schotzko, Michele, additional, Peterson, Eric, additional, Simmons, Heather A, additional, Mejia, Andres, additional, Golos, Thaddeus G, additional, Friedrich, Thomas C, additional, and O’Connor, David H, additional

Published
2021
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10. #79: Modeling Zika Virus Tissue Tropism in Rhesus Macaques to Define the Risk of Donor-derived Transmission

Author

Treadway, Taylor A, primary, Shepherd, Phoenix M, additional, Newman, Christina M, additional, Mohr, Emma L, additional, Dudley, Dawn M, additional, Breitbach, Meghan E, additional, Yamamoto, Keisuke, additional, Stewart, Laurel M, additional, Koenig, Michelle R, additional, Bliss, Mason, additional, Rybarczyk, Sierra L, additional, Weiler, Andrea M, additional, Semler, Matthew R, additional, Mitzey, Ann, additional, Razo, Elaina, additional, Schotzko, Michele, additional, Peterson, Eric, additional, Simmons, Heather A, additional, Mejia, Andres, additional, Golos, Thaddeus G, additional, Friedrich, Thomas C, additional, and O’Connor, David H, additional

Published
2021
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11. Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

Author

Koenig, Michelle R., primary, Razo, Elaina, additional, Mitzey, Ann, additional, Newman, Christina M., additional, Dudley, Dawn M., additional, Breitbach, Meghan E., additional, Semler, Matthew R., additional, Stewart, Laurel M., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Bach, Kathryn M., additional, Mohns, Mariel S., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Fritsch, Michael, additional, Dennis, Maria, additional, Teixeira, Leandro B. C., additional, Schotzko, Michele L., additional, Nork, T. Michael, additional, Rasmussen, Carol A., additional, Katz, Alex, additional, Nair, Veena, additional, Hou, Jiancheng, additional, Hartman, Amy, additional, Ver Hoeve, James, additional, Kim, Charlene, additional, Schneider, Mary L., additional, Ausderau, Karla, additional, Kohn, Sarah, additional, Jaeger, Anna S., additional, Aliota, Matthew T., additional, Hayes, Jennifer M., additional, Schultz-Darken, Nancy, additional, Eickhoff, Jens, additional, Antony, Kathleen M., additional, Noguchi, Kevin, additional, Zeng, Xiankun, additional, Permar, Sallie, additional, Prabhakaran, Vivek, additional, Capuano, Saverio, additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, O’Connor, David H., additional, and Mohr, Emma L., additional

Published
2020
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12. Derivation of macaque trophoblast stem cells

Author

Schmidt, Jenna Kropp, primary, Meyer, Michael G., additional, Wiepz, Gregory J., additional, Block, Lindsey N., additional, Dusek, Brittany M., additional, Kroner, Kamryn M., additional, Bertogliat, Mario J., additional, Keding, Logan T., additional, Koenig, Michelle R., additional, Mean, Katherine D., additional, and Golos, Thaddeus G., additional

Published
2020
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13. Long-Term Protection of Rhesus Macaques from Zika Virus Reinfection

Author

Moreno, Gage K., primary, Newman, Christina M., additional, Koenig, Michelle R., additional, Mohns, Mariel S., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Weisgrau, Kim L., additional, Vosler, Logan J., additional, Pomplun, Nicholas, additional, Schultz-Darken, Nancy, additional, Rakasz, Eva, additional, Dudley, Dawn M., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2020
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14. Pharyngeal motor cortex grey matter abnormalities and retinal photoreceptor layer dysfunction in macaques exposed to Zika virus in utero

Author

Koenig, Michelle R., Razo, Elaina, Mitzey, Ann, Semler, Matthew R., Stewart, Laurel M., Breitbach, Meghan E., Newman, Christina M., Dudley, Dawn M., Weiler, Andrea M., Rybarczyk, Sierra, Bach, Kathryn M., Mohns, Mariel S., Simmons, Heather A., Mejia, Andres, Dennis, Maria, Teixeira, Leandro B. C., Schotzko, Michele L., Nork, T. Michael, Rasmussen, Carol A., Katz, Alex, Hou, Jiancheng, Hartman, Amy, Ver Hoeve, James, Kim, Charlene, Schneider, Mary L., Ausderau, Karla, Kohn, Sarah, Jaeger, Anna S., Aliota, Matthew T., Salamat, M. Shahriar, Hayes, Jennifer M., Schultz-Darken, Nancy, Eickhoff, Jens, Antony, Kathleen M., Noguchi, Kevin, Zeng, Xiankun, Permar, Sallie, Ikonomidou, Chrysanthy, Prabhakaran, Vivek, Capuano III, Saverio, Friedrich, Thomas C., Golos, Thaddeus G., O’Connor, David H., and Mohr, Emma L.

Abstract

One third of infants who have prenatal Zika virus (ZIKV) exposure and lack significant defects consistent with congenital Zika syndrome (CZS) manifest neurodevelopmental deficits in their second year of life. We hypothesized that prenatal ZIKV exposure would lead to brain abnormalities and neurodevelopmental delays in infant macaques, as measured by quantitative hearing, neurodevelopmental, ocular and brain imaging studies. We inoculated 5 pregnant rhesus macaques with ZIKV during the first trimester, monitored pregnancies with serial ultrasounds, determined plasma viral RNA (vRNA) loads, and evaluated the infants for birth defects and neurodevelopmental deficits during their first week of life. ZIKV-exposed and control infants (n=16) were evaluated with neurobehavioral assessments, ophthalmic examinations, optical coherence tomography, electroretinography with visual evoked potentials, hearing examinations, magnetic resonance imaging (MRI) of the brain, gross post mortem examination, and histopathological and vRNA analyses of approximately 40 tissues and fluids. All 5 dams had ZIKV vRNA in plasma and seroconverted following ZIKV inoculation. One pregnancy resulted in a stillbirth. The ZIKV-exposed infants had decreased cumulative feeding volumes and weight gains compared with control infants, and also had grey matter abnormalities in the pharyngeal motor cortex identified by quantitative voxel-based morphometric comparisons. Quantitative ocular studies identified differences between ZIKV-exposed and control infants in retinal layer thicknesses and electroretinograms that were not identified in qualitative ophthalmic evaluations. Despite these findings of neuropathology, no ZIKV vRNA or IgM was detected in the infants. This suggests that ZIKV exposure without measurable vertical transmission can affect brain development in utero and that subtle neurodevelopmental delays may be detected with quantitative analyses in early infancy. Quantitative brain analyses, such as these, may predict neurodevelopmental delays that manifest later in childhood and allow early intervention and targeted therapies to improve functional outcomes of ZIKV exposed children. Author Summary Human infants with born to women with Zika virus infection during pregnancy are at risk for neurodevelopmental deficits later in childhood. We hypothesized that we could identify brain abnormalities associated with neurodevelopmental deficits in infant macaques exposed to Zika virus during pregnancy. We identified brain and retinal abnormalities in Zika virus-exposed infant macaques during their first week of life, which may be related to their findings of decreased feeding and slower weight gain. None of the infants had direct evidence of Zika virus infection in their tissues, body fluids or by detection of IgM antibodies. This suggests that Zika virus exposure during pregnancy can affect brain development in utero and that quantitative brain imaging analyses may predict neurodevelopmental delays. Early identification of Zika virus-exposed children at risk of neurodevelopmental deficits would promote targeted therapies in this population and improve the functional outcome of all Zika virus exposed children.

Published
2019
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15. Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

Author

Koenig, Michelle R., primary, Razo, Elaina, additional, Mitzey, Ann, additional, Newman, Christina M., additional, Dudley, Dawn M., additional, Breitbach, Meghan E., additional, Semler, Matthew R., additional, Stewart, Laurel M., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Bach, Kathryn M., additional, Mohns, Mariel S., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Fritsch, Michael, additional, Dennis, Maria, additional, Teixeira, Leandro B. C., additional, Schotzko, Michele L., additional, Nork, T. Michael, additional, Rasmussen, Carol A., additional, Katz, Alex, additional, Nair, Veena, additional, Hou, Jiancheng, additional, Hartman, Amy, additional, Hoeve, James Ver, additional, Kim, Charlene, additional, Schneider, Mary L., additional, Ausderau, Karla, additional, Kohn, Sarah, additional, Jaeger, Anna S., additional, Aliota, Matthew T., additional, Hayes, Jennifer M., additional, Schultz-Darken, Nancy, additional, Eickhoff, Jens, additional, Antony, Kathleen M., additional, Noguchi, Kevin, additional, Zeng, Xiankun, additional, Permar, Sallie, additional, Prabhakaran, Vivek, additional, Capuano, Saverio, additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, O’Connor, David H., additional, and Mohr, Emma L., additional

Published
2019
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16. Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques

Author

Breitbach, Meghan E., primary, Newman, Christina M., additional, Dudley, Dawn M., additional, Stewart, Laurel M., additional, Aliota, Matthew T., additional, Koenig, Michelle R., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Crooks, Chelsea M., additional, Young, Ginger, additional, Semler, Matthew R., additional, Weiler, Andrea M., additional, Barry, Gabrielle L., additional, Heimsath, Holly, additional, Mohr, Emma L., additional, Eichkoff, Jens, additional, Newton, Wendy, additional, Peterson, Eric, additional, Schultz-Darken, Nancy, additional, Permar, Sallie R., additional, Dean, Hansi, additional, Capuano, Saverio, additional, Osorio, Jorge E., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2019
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17. Long-term protection of rhesus macaques from Zika virus reinfection

Author

Moreno, Gage K., primary, Newman, Christina M., additional, Koenig, Michelle R., additional, Mohns, Mariel S., additional, Weiler, Andrea M., additional, Rybarczyk, Sierra, additional, Vosler, Logan J., additional, Pomplun, Nicholas, additional, Schultz-Darken, Nancy, additional, Rakasz, Eva, additional, Dudley, Dawn M., additional, Friedrich, Thomas C., additional, and O’Connor, David H., additional

Published
2019
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19. Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

Author

Aliota, Matthew T., primary, Dudley, Dawn M., additional, Newman, Christina M., additional, Weger-Lucarelli, James, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Breitbach, Meghan E., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Haj, Amelia K., additional, Moriarty, Ryan V., additional, Mohns, Mariel S., additional, Mohr, Emma L., additional, Venturi, Vanessa, additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Schotzko, Michele L., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Hayes, Jennifer M., additional, Capuano, Saverio, additional, Davenport, Miles P., additional, Friedrich, Thomas C., additional, Ebel, Gregory D., additional, O’Connor, Shelby L., additional, and O’Connor, David H., additional

Published
2018
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20. Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Author

Dudley, Dawn M., primary, Newman, Christina M., additional, Lalli, Joseph, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Mohns, Mariel S., additional, Breitbach, Meghan E., additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Mohr, Emma L., additional, Capuano III, Saverio, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, O’Connor, David H., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2017
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21. Molecularly barcoded Zika virus libraries to probein vivoevolutionary dynamics

Author

Aliota, Matthew T., primary, Dudley, Dawn M., additional, Newman, Christina M., additional, Weger-Lucarelli, James, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Breitbach, Meghan E., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Mohns, Mariel S., additional, Mohr, Emma L., additional, Venturi, Vanessa, additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Schotzko, Michele L., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Hayes, Jennifer M., additional, Capuano, Saverio, additional, Davenport, Miles P., additional, Friedrich, Thomas C., additional, Ebel, Gregory D., additional, O’Connor, Shelby L., additional, and O’Connor, David H., additional

Published
2017
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22. Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection

Author

Bailey, Adam L., primary, Buechler, Connor R., additional, Matson, Daniel R., additional, Peterson, Eric J., additional, Brunner, Kevin G., additional, Mohns, Mariel S., additional, Breitbach, Meghan, additional, Stewart, Laurel M., additional, Ericsen, Adam J., additional, Newman, Christina M., additional, Koenig, Michelle R., additional, Mohr, Emma, additional, Tan, John, additional, Capuano, Saverio, additional, Simmons, Heather A., additional, Yang, David T., additional, and O’Connor, David H., additional

Published
2017
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23. Plasma miRNA, an emerging biomarker for pancreatic cancer

Author

Yu, Xiazhen, Koenig, Michelle R., and Zhu, Yuwen

Subjects
Perspective
Abstract

Pancreatic cancer (PC) is one of the most dangerous types of cancer, much due to the lack of clinical symptoms in early stages. Early, noninvasive methods of detecting PC remain a great challenge in clinical practices. MicroRNAs (miRNAs), small and non-coding single-strand RNAs, emerge as potential biomarkers for PC. MiRNAs are involved in PC progression and abnormal level of miRNAs in plasma has been observed in PC patients. A multi-center study recently conducted by Xu and colleagues demonstrated the potential value of using circulating miRNAs to distinguish PC from normal donors and other pancreas-related diseases.

Published
2015

24. Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

Author

Dudley, Dawn M., primary, Newman, Christina M., additional, Lalli, Joseph, additional, Stewart, Laurel M., additional, Koenig, Michelle R., additional, Weiler, Andrea M., additional, Semler, Matthew R., additional, Barry, Gabrielle L., additional, Zarbock, Katie R., additional, Mohns, Mariel S., additional, Breitbach, Meghan E., additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Newton, Wendy, additional, Mohr, Emma L., additional, Capuano, Saverio, additional, Osorio, Jorge E., additional, O’Connor, Shelby L., additional, O’Connor, David H., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2017
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25. Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer

Author

Bastman, Jill J., primary, Serracino, Hilary S., additional, Zhu, Yuwen, additional, Koenig, Michelle R., additional, Mateescu, Valerica, additional, Sams, Sharon B., additional, Davies, Kurtis D., additional, Raeburn, Christopher D., additional, McIntyre, Robert C., additional, Haugen, Bryan R., additional, and French, Jena D., additional

Published
2016
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28. CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers.

Author

Tian, Yu, Sun, Yi, Gao, Fan, Koenig, Michelle R., Sunderland, Alexander, Fujiwara, Yuki, Torphy, Robert J., Chen, Lieping, Edil, Barish H., Schulick, Richard D., and Zhu, Yuwen

Subjects
T cells, EPITHELIUM, MEMORY, CELLS, TISSUES
Abstract

The CD28H/B7-H5 pathway is a newly identified pathway of the B7 family. In human peripheral blood, the receptor CD28H is preferentially expressed on naïve T cells and repetitive stimulation of T cells leads to the loss of CD28H expression. Here we examined the expression of the CD28H/B7-H5 pathway in human peripheral tissues, as well as in human cancers. We found that CD28H is preferentially expressed on T cells with tissue-resident phenotypes (TRM). Supporting that, stimulation via IL-15 and TGF-β, presumably major cytokines essential for TRM cell homeostasis, sustains CD28H expression on T cells. The ligand B7-H5 is constitutively expressed on normal epithelium of human oral-gastrointestinal tracts. In human cancers, CD28H is preferentially present on tumor infiltrating lymphocytes (TILs) with TRM features and identifies a TRM subset with less cytotoxicity. Taken together, our studies suggest that the CD28H/B7-H5 pathway involves the interactions between TRM cells and epithelium, and could be important for human TRM homeostasis and function. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Plasma miRNA, an emerging biomarker for pancreatic cancer.

Author

Yu X, Koenig MR, and Zhu Y

Abstract

Pancreatic cancer (PC) is one of the most dangerous types of cancer, much due to the lack of clinical symptoms in early stages. Early, noninvasive methods of detecting PC remain a great challenge in clinical practices. MicroRNAs (miRNAs), small and non-coding single-strand RNAs, emerge as potential biomarkers for PC. MiRNAs are involved in PC progression and abnormal level of miRNAs in plasma has been observed in PC patients. A multi-center study recently conducted by Xu and colleagues demonstrated the potential value of using circulating miRNAs to distinguish PC from normal donors and other pancreas-related diseases.

Published
2015
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