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1. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate and risk of breast cancer: a nested case-control study

Author

Koenig, Karen L., Scarmo, Stephanie, Afanasyeva, Yelena, Clendenen, Tess V., Ueland, Per Magne, and Zeleniuch-Jacquotte, Anne

Subjects
Oncology, Experimental -- Health aspects, Folic acid -- Health aspects, Mass spectrometry -- Health aspects, Liquid chromatography -- Health aspects, Breast cancer -- Risk factors, Cancer -- Research, Food/cooking/nutrition, Health
Abstract

Background/Objectives Folates found in natural foods are thought to protect against cancer. However, folic acid (FA), a synthetic form of folate used in supplements and fortified foods, may increase breast cancer risk if present in unmetabolized form (UMFA) in the circulation. This study examined the associations of serum UMFA and 5-methyltetrahydrofolate (5-mTHF), the predominant form of circulating folate, with breast cancer risk. Subjects/Methods We conducted a nested case-control study in a prospective cohort. In total, 553 cases of invasive breast cancer, diagnosed before mandatory FA fortification of grain in the US in 1998, were individually-matched to 1059 controls. Serum UMFA and 5-mTHF were measured using liquid chromatography-tandem mass spectrometry in stored serum samples, and 5-mTHF was corrected for storage degradation. Results Serum UMFA was not associated with breast cancer risk: the percentage of women with detectable levels of UMFA was similar in cases and controls (18% and 20%, respectively; p = 0.46). Two tag-SNPs in the promoter region of the FA-metabolizing gene were also not associated with risk. There was a marginally significant inverse association of 5-mTHF.sub.corrected with breast cancer risk (odds ratio for the highest vs. lowest quintile = 0.69, 95% CI = 0.49 to 0.97; p.sub.trend = 0.08). Conclusions Circulating UMFA was not associated with breast cancer risk. These results apply to countries without mandatory FA food fortification. Studies are needed in countries with mandatory fortification, where levels of UMFA are much higher than in our study., Author(s): Karen L. Koenig [sup.1], Stephanie Scarmo [sup.1], Yelena Afanasyeva [sup.1], Tess V. Clendenen [sup.1], Per Magne Ueland [sup.2], Anne Zeleniuch-Jacquotte [sup.1] [sup.3] Author Affiliations: (1) Departments of Population Health [...]

Published
2020
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2. Mid‐life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late‐life subjective cognitive complaints in women.

Author

Song, Yixiao, Wu, Fen, Sharma, Sneha, Clendenen, Tess V., India‐Aldana, Sandra, Afanasyeva, Yelena, Gu, Yian, Koenig, Karen L., Zeleniuch‐Jacquotte, Anne, and Chen, Yu

Abstract

INTRODUCTION: Evidence is limited on the role of mid‐life Dietary Approaches to Stop Hypertension (DASH) diet in late‐life subjective cognitive complaints (SCCs). METHODS: We included 5116 women (mean age in 1985–1991: 46 years) from the New York University Women's Health Study. SCCs were assessed from 2018 to 2020 (mean age: 79 years) by a 6‐item questionnaire. RESULTS: Compared to women in the bottom quartile of the DASH scores, the odds ratio (OR) for having two or more SCCs was 0.83 (95% confidence interval: 0.70–0.99) for women in the top quartile of DASH scores at baseline (P for trend = 0.019). The association was similar with multiple imputation and inverse probability weighting to account for potential selection bias. The inverse association was stronger in women without a history of cancer (P for interaction = 0.003). DISCUSSION: Greater adherence to the DASH diet in mid‐life was associated with lower prevalence of late‐life SCCs in women. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Long-Term Exposure to Walkable Residential Neighborhoods and Risk of Obesity-Related Cancer in the New York University Women’s Health Study (NYUWHS)

Author

India-Aldana, Sandra, primary, Rundle, Andrew G., additional, Quinn, James W., additional, Clendenen, Tess V., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional

Published
2023
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7. Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model

Author

Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Zeleniuch-Jacquotte, Anne, and Liu, Mengling

Published
2019
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8. Neighborhood walkability and sex steroid hormone levels in women

Author

India-Aldana, Sandra, primary, Rundle, Andrew G., additional, Clendenen, Tess V., additional, Quinn, James W., additional, Arslan, Alan A., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional

Published
2022
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10. Gut Microbiota and Subjective Memory Complaints in Older Women

Author

Wu, Fen, primary, Davey, Samuel, additional, Clendenen, Tess V., additional, Koenig, Karen L., additional, Afanasyeva, Yelena, additional, Zhou, Boyan, additional, Bedi, Sukhleen, additional, Li, Huilin, additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional

Published
2022
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11. Circulating prolactin levels and risk of epithelial ovarian cancer

Author

Clendenen, Tess V., Arslan, Alan A., Lokshin, Anna E., Liu, Mengling, Lundin, Eva, Koenig, Karen L., Berrino, Franco, Hallmans, Goran, Idahl, Annika, Krogh, Vittorio, Lukanova, Annekatrin, Marrangoni, Adele, Muti, Paola, Nolen, Brian M., Ohlson, Nina, Shore, Roy E., Sieri, Sabina, and Zeleniuch-Jacquotte, Anne

Published
2013

12. Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer

Author

Lundin, Eva, Wirgin, Isaac, Lukanova, Annekatrin, Afanasyeva, Yelena, Krogh, Vittorio, Axelsson, Tomas, Hemminki, Kari, Clendenen, Tess V., Arslan, Alan A., Ohlson, Nina, Sieri, Sabina, Roy, Nirmal, Koenig, Karen L., Idahl, Annika, Berrino, Franco, Toniolo, Paolo, Hallmans, Göran, Försti, Asta, Muti, Paola, Lenner, Per, Shore, Roy E., and Zeleniuch-Jacquotte, Anne

Published
2012
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15. Neighborhood Walkability and Sex Steroid Hormone Levels in Women

Author

India Aldana, Sandra, primary, Rundle, Andrew G., additional, Clendenen, Tess V., additional, Quinn, James W., additional, Arslan, Alan A., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional

Published
2022
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16. A Pooled Analysis of 12 Cohort Studies of Dietary Fat, Cholesterol and Egg Intake and Ovarian Cancer

Author

Genkinger, Jeanine M., Hunter, David J., Spiegelman, Donna, Anderson, Kristin E., Beeson, W. Lawrence, Buring, Julie E., Colditz, Graham A., Fraser, Gary E., Freudenheim, Jo L., Goldbohm, R. Alexandra, Hankinson, Susan E., Koenig, Karen L., Larsson, Susanna C., Leitzmann, Michael, McCullough, Marjorie L., Miller, Anthony B., Rodriguez, Carmen, Rohan, Thomas E., Ross, Julie A., Schatzkin, Arthur, Schouten, Leo J., Smit, Ellen, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zhang, Shumin M., and Smith-Warner, Stephanie A.

Published
2006
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19. Neighborhood Walkability and Mortality in a Prospective Cohort of Women

Author

India Aldana, Sandra, primary, Rundle, Andrew G., additional, Zeleniuch Jacquotte, Anne, additional, Quinn, James W., additional, Kim, Byoungjun, additional, Afanasyeva, Yelena, additional, Clendenen, Tess V., additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, and Chen, Yu, additional

Published
2021
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20. Neighborhood Walkability and Sex Hormone Levels in Women

Author

India Aldana, Sandra, primary, Rundle, Andrew G., additional, Clendenen, Tess V., additional, Quinn, James W., additional, Arslan, Alan A., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Thorpe, Lorna E., additional, Zeleniuch Jacquotte, Anne, additional, and Chen, Yu, additional

Published
2021
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21. Neighborhood Walkability and Mortality in a Prospective Cohort of Women

Author

India-Aldana, Sandra, primary, Rundle, Andrew G., additional, Zeleniuch-Jacquotte, Anne, additional, Quinn, James W., additional, Kim, Byoungjun, additional, Afanasyeva, Yelena, additional, Clendenen, Tess V., additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, and Chen, Yu, additional

Published
2021
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25. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Author

Clendenen, Tess V, primary, Ge, Wenzhen, additional, Koenig, Karen L, additional, Afanasyeva, Yelena, additional, Agnoli, Claudia, additional, Bertone-Johnson, Elizabeth, additional, Brinton, Louise A, additional, Darvishian, Farbod, additional, Dorgan, Joanne F, additional, Eliassen, A Heather, additional, Falk, Roni T, additional, Hallmans, Göran, additional, Hankinson, Susan E, additional, Hoffman-Bolton, Judith, additional, Key, Timothy J, additional, Krogh, Vittorio, additional, Nichols, Hazel B, additional, Sandler, Dale P, additional, Schoemaker, Minouk J, additional, Sluss, Patrick M, additional, Sund, Malin, additional, Swerdlow, Anthony J, additional, Visvanathan, Kala, additional, Liu, Mengling, additional, and Zeleniuch-Jacquotte, Anne, additional

Published
2021
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26. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Author

Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, Zeleniuch-Jacquotte, Anne, Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, and Zeleniuch-Jacquotte, Anne

Abstract

Context: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. Objective: This study assessed whether risk factors for breast cancer are correlates of AMH concentration. Methods: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population. Results: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05). Conclusion: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

Published
2021
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29. Body-mass index and mortality among 1.46 million white adults

Author

de Gonzalez, Amy Berrington, Hartge, Patricia, Cerhan, James R., Flint, Alan J., Hannan, Lindsay, MacInnis, Robert J., Moore, Steven C., Tobias, Geoffrey S., Anton-Culver, Hoda, Freeman, Laura Beane, Beeson, W. Lawrence, Clipp, Sandra L., English, Dallas R., Folsom, Aaron R., Freedman, Michal, Giles, Graham, Hakansson, Niclas, Henderson, Katherine D., Hoffman-Bolton, Judith, Hoppin, Jane A., Koenig, Karen L., I-Min Lee, Linet, Martha S., Yikyung Park, Sesso, Howard D., Weiderpass, Elisabete, Willcox, Bradley J., Pocobelli, Gaia, Schatzkin, Arthur, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Willett, Walter C., and Thun, Michael J.

Subjects
Mortality -- United States, Mortality -- Risk factors, Obesity -- Risk factors, Body mass index -- Measurement, Body mass index -- Health aspects
Abstract

The optimal body-mass index (BMI) range is assessed and has provided stable estimates of the risks associated with being overweight, obese, and morbidly obese, with minimal confounding due to smoking or prevalent disease. The studies have shown that for non-Hispanic whites, both overweight and obesity are associated with increased all-cause mortality and also underweight.

Published
2010

30. Circulating 25-Hydroxyvitamin D and Risk of Kidney Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Gallicchio, Lisa, Moore, Lee E., Stevens, Victoria L., Ahn, Jiyoung, Albanes, Demetrius, Hartmuller, Virginia, Setiawan, V. Wendy, Helzlsouer, Kathy J., Yang, Gong, Xiang, Yong-Bing, Shu, Xiao-Ou, Snyder, Kirk, Weinstein, Stephanie J., Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Cai, Qiuyin, Campbell, David S., Chen, Yu, Chow, Wong-Ho, Horst, Ronald L., Kolonel, Laurence N., McCullough, Marjorie L., Purdue, Mark P., and Koenig, Karen L.

Published
2010
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31. Circulating 25-Hydroxyvitamin D and the Risk of Rarer Cancers: Design and Methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Gallicchio, Lisa, Helzlsouer, Kathy J., Chow, Wong-Ho, Freedman, D. Michal, Hankinson, Susan E., Hartge, Patricia, Hartmuller, Virginia, Harvey, Chinonye, Hayes, Richard B., Horst, Ronald L., Koenig, Karen L., Kolonel, Laurence N., Laden, Francine, McCullough, Marjorie L., Parisi, Dominick, Purdue, Mark P., Shu, Xiao-Ou, Snyder, Kirk, Stolzenberg-Solomon, Rachael Z., Tworoger, Shelley S., Varanasi, Arti, Virtamo, Jarmo, Wilkens, Lynne R., Xiang, Yong-Bing, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Bertrand, Kimberly, and Weinstein, Stephanie J.

Published
2010
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32. Circulating 25-Hydroxyvitamin D and Risk of Endometrial Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Author

Zeleniuch-Jacquotte, Anne, Gallicchio, Lisa, Hartmuller, Virginia, Helzlsouer, Kathy J., McCullough, Marjorie L., Setiawan, V. Wendy, Shu, Xiao-Ou, Weinstein, Stephanie J., Weiss, Jocelyn M., Arslan, Alan A., De Vivo, Immaculata, Gao, Yu-Tang, Hayes, Richard B., Henderson, Brian E., Horst, Ronald L., Koenig, Karen L., Patel, Alpa V., Purdue, Mark P., Snyder, Kirk, Steplowski, Emily, Yu, Kai, Zheng, Wei, and Hankinson, Susan E.

Published
2010
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33. Job strain in physical therapists

Author

Campo, Marc A., Weiser, Sherri, and Koenig, Karen L.

Subjects
Job stress -- Risk factors -- Patient outcomes -- Surveys -- Psychological aspects -- Health aspects, Physical therapists -- Health aspects -- Psychological aspects -- Surveys, Health
Abstract

Background. Job stress has been associated with poor outcomes. In focus groups and small-sample surveys, physical therapists have reported high levels of job stress. Studies of job stress in physical therapy with larger samples are needed. Objective. The purposes of this study were: (1) to determine the levels of psychological job demands and job control reported by physical therapists in a national sample, (2) to compare those levels with national norms, and (3) to determine whether high demands, low control, or a combination of both (job strain) increases the risk for turnover or work-related pain. Design. This was a prospective cohort study with a 1-year follow-up period. Methods. Participants were randomly selected members of the American Physical Therapy Association (n=882). Exposure assessments included the Job Content Questionnaire (JCQ), a commonly used instrument for evaluation of the psychosocial work environment. Outcomes included job turnover and work-related musculoskeletal disorders. Results. Compared with national averages, the physical therapists reported moderate job demands and high levels of job control. About 16% of the therapists reported changing jobs during follow-up. Risk factors for turnover included high job demands, low job control, job strain, female sex, and younger age. More than one haft of the therapists reported work-related pain. Risk factors for work-related pain included low job control and job strain. Limitations. The JCQ measures only limited dimensions of the psychosocial work environment. All data were self-reported and subject to associated bias. Conclusions. Physical therapists' views of their work environments were positive, including moderate levels of demands and high levels of control. Those therapists with high levels of demands and low levels of control, however, were at increased risk for both turnover and work-related pain. Physical therapists should consider the psychosocial work environment, along with other factors, when choosing a job., Job stress increases the risk for a variety of adverse outcomes. These outcomes include burnout, (1,2) turnover, (3) sickness absence, (4) and work-related musculoskeletal disorders (WMSDs). (5) Job stress has [...]

Published
2009

36. Work-related musculoskeletal disorders in physical therapists: a prospective cohort study with 1-year follow-up

Author

Campo, Marc, Weiser, Sherri, Koenig, Karen L., and Nordin, Margareta

Subjects
Occupational diseases -- Risk factors -- Diagnosis, Musculoskeletal diseases -- Risk factors -- Diagnosis, Physical therapists -- Practice -- Health aspects, Health
Abstract

Background. Work-related musculoskeletal disorders (WMSDs) have a significant impact on physical therapists, but few studies have addressed the issue. Research is needed to determine the scope of the problem and the effects of specific risk factors. Objectives. The objectives of this study were: (1) to determine the 1-year incidence rate of WMSDs in physical therapists and (2) to determine the effects of specific risk factors. Design. This was a prospective cohort study with 1-year follow-up. Methods. Subjects were randomly selected American Physical Therapy Association members (N=882). Exposure assessment included demographic data, physical risk factors, job strain, and specific physical therapy tasks. The primary outcome was WMSDs, with a severity rating of at least 4/10 and present at least once a month or lasting longer than a week. Results. The response rate to the baseline questionnaire was 67%. Ninety-three percent of the subjects who responded to the baseline questionnaire responded to the follow-up questionnaire. The 1-year incidence rate of WMSDs was 20.7%. Factors that increased the risk for WMSDs included patient transfers, patient repositioning, bent or twisted postures, joint mobilization, soft tissue work, and job strain. Limitations. The primary limitation of this study was the number of therapists who had a change in their job situation during the follow-up year. Conclusions. Work-related musculoskeletal disorders are prevalent in physical therapists. Physical therapy exposures, patient handling, and manual therapy, in particular, increase the risk for WMSDs., There is evidence that work-related musculoskeletal disorders (WMSDs) have a significant impact on physical therapists. In prior studies, (1-6) physical therapists reported taking sick time, changing practice habits, changing work [...]

Published
2008

37. Circulating enterolactone and risk of endometrial cancer

Author

Zeleniuch-Jacquotte, Anne, Lundin, Eva, Micheli, Andrea, Koenig, Karen L., Lenner, Per, Muti, Paola, Shore, Roy E., Johansson, Ingegerd, Krogh, Vittorio, Lukanova, Annekatrin, Stattin, Pär, Afanasyeva, Yelena, Rinaldi, Sabina, Arslan, Alan A., Kaaks, Rudolf, Berrino, Franco, Hallmans, Göran, Toniolo, Paolo, and Adlercreutz, Herman

Published
2006
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42. Temporal reliability of cytokines and growth factors in EDTA plasma

Author

Marrangoni Adele M, Koenig Karen L, Hallmans Göran, Idahl Annika, Lokshin Anna E, Arslan Alan A, Clendenen Tess V, Nolen Brian M, Ohlson Nina, Zeleniuch-Jacquotte Anne, and Lundin Eva

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Cytokines are involved in the development of chronic diseases, including cancer. It is important to evaluate the temporal reproducibility of cytokines in plasma prior to conducting epidemiologic studies utilizing these markers. Findings We assessed the temporal reliability of CRP, 22 cytokines and their soluble receptors (IL-1α, IL-1β, IL-1RA, IL-2, sIL-2R, IL-4, IL-5, IL-6, sIL-6R, IL-7, IL-8, IL-10, IL-12p40, IL-12p70, IL-13, IL-15, IL-17, TNFα, sTNF-R1, sTNF-R2, IFNα, IFNγ) and eight growth factors (GM-CSF, EGF, bFGF, G-CSF, HGF, VEGF, EGFR, ErbB2) in repeated EDTA plasma samples collected an average of two years apart from 18 healthy women (age range: 42-62) enrolled in a prospective cohort study. We also estimated the correlation between serum and plasma biomarker levels using 18 paired clinical samples from postmenopausal women (age range: 75-86). Twenty-six assays were able to detect their analytes in at least 70% of samples. Of those 26 assays, we observed moderate to high intra-class correlation coefficients (ICCs)(ranging from 0.53-0.89) for 22 assays, and low ICCs (0-0.47) for four assays. Serum and plasma levels were highly correlated (r > 0.6) for most markers, except for seven assays (r < 0.5). Conclusions For 22 of the 31 biomarkers, a single plasma measurement is a reliable estimate of a woman's average level over a two-year period.

Published
2010
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44. Circulating anti-Müllerian hormone and breast cancer risk : a study in ten prospective cohorts

Author

Ge, Wenzhen, Clendenen, Tess V., Afanasyeva, Yelena, Koenig, Karen L., Agnoli, Claudia, Brinton, Louise A., Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, Zeleniuch-Jacquotte, Anne, Ge, Wenzhen, Clendenen, Tess V., Afanasyeva, Yelena, Koenig, Karen L., Agnoli, Claudia, Brinton, Louise A., Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, and Zeleniuch-Jacquotte, Anne

Abstract

A strong positive association has been observed between circulating anti‐Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the paucity of biomarkers of breast cancer risk in premenopausal women. We conducted a consortium study including ten prospective cohorts that had collected blood from premenopausal women. A nested case–control design was implemented within each cohort. A total of 2,835 invasive (80%) and in situ (20%) breast cancer cases were individually matched to controls (n = 3,122) on age at blood donation. AMH was measured using a high sensitivity enzyme‐linked immunoabsorbent assay. Conditional logistic regression was applied to the aggregated dataset. There was a statistically significant trend of increasing breast cancer risk with increasing AMH concentration (ptrend across quartiles <0.0001) after adjusting for breast cancer risk factors. The odds ratio (OR) for breast cancer in the top vs. bottom quartile of AMH was 1.60 (95% CI = 1.31–1.94). Though the test for interaction was not statistically significant (pinteraction = 0.15), the trend was statistically significant only for tumors positive for both estrogen receptor (ER) and progesterone receptor (PR): ER+/PR+: ORQ4–Q1 = 1.96, 95% CI = 1.46–2.64, ptrend <0.0001; ER+/PR−: ORQ4–Q1 = 0.82, 95% CI = 0.40–1.68, ptrend = 0.51; ER−/PR+: ORQ4–Q1 = 3.23, 95% CI = 0.48–21.9, ptrend = 0.26; ER−/PR−: ORQ4–Q1 = 1.15, 95% CI = 0.63–2.09, ptrend = 0.60. The association was observed for both pre‐ (ORQ4–Q1= 1.35, 95% CI = 1.05–1.73) and post‐menopausal (ORQ4–Q1 = 1.61, 95% CI = 1.03–2.53) breast cancer (pinteraction = 0.34). In this large consortium study, we confirmed that AMH is associated with breast cancer risk, with a 60% increase in risk for women in the top vs. bottom quartile of AMH. What's new? To make informed decisions about screening and prevention, women need tools to accurately asses

Published
2018
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45. A prospective study of endogenous estrogens and breast cancer in postmenopausal women

Author

Toniolo, Paolo G., Levitz, Mortimer, Zeleniuch-Jacquotte, Anne, Banerjee, Sila, Koenig, Karen L., Shore, Roy E., Strax, Philip, and Pasternack, Bernard S.

Subjects
Breast cancer -- Risk factors, Estrogen -- Health aspects, Postmenopausal women -- Health aspects, Health
Abstract

Background. Circumstantial evidence links endogenous estrogens to increased risk of breast cancer in women, but direct epidemiologic support is limited. In particular, only a few small prospective studies have addressed this issue. Purpose: Our purpose was to assess breast cancer risk in relation to circulating levels of the two major endogenous estrogens, estrone and estradiol, measured before the clinical onset of the disease. Methods: The association between serum levels of estrogens and the risk of breast cancer was examined in a prospective cohort study of 14 291 New York City women, 35-65 years of age, who received screening for breast cancer at the time of blood sampling and who had not been diagnosed with breast cancer. During the first 5 1\2 years of study, we identified 130 breast cancers among the postmenopausal group (7063 women, 35 509 person-years). The case subjects and twice as many postmenopausal control subjects were included in a case-control study nested within the cohort. Biochemical analyses for percent free estradiol, percent estradiol bound to sex hormone-binding globulin (SHBG), total estradiol, estrone, and follicle-stimulating hormone were performed on sera that had been kept at -80[degrees] since sampling. Results: For increasing quartiles of total estradiol, the odds ratio (ORs) of breast cancer, as adjusted for Quetelet index (weight in kilograms divided by the square of the height in meters), were 1.0, 0.9, 1.8, and 1.8 (P value for trend = .06); the ORs for increasing quartiles of estrone were 1.0, 2.2, 3.7, and 2.5 (P value for trend = .06). For increasing quartiles of free estradiol, defined as the fraction of estradiol that is not bound to proteins, the Quetelet index-adjusted ORs of breast cancer were 1.0, 1.4, 3.0, and 2.9 (P value for trend

Published
1995

46. Circulating anti‐Müllerian hormone and breast cancer risk: A study in ten prospective cohorts

Author

Ge, Wenzhen, primary, Clendenen, Tess V., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Agnoli, Claudia, additional, Brinton, Louise A., additional, Dorgan, Joanne F., additional, Eliassen, A. Heather, additional, Falk, Roni T., additional, Hallmans, Göran, additional, Hankinson, Susan E., additional, Hoffman‐Bolton, Judith, additional, Key, Timothy J., additional, Krogh, Vittorio, additional, Nichols, Hazel B., additional, Sandler, Dale P., additional, Schoemaker, Minouk J., additional, Sluss, Patrick M., additional, Sund, Malin, additional, Swerdlow, Anthony J., additional, Visvanathan, Kala, additional, Liu, Mengling, additional, and Zeleniuch‐Jacquotte, Anne, additional

Published
2018
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48. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study

Author

Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Axelsson, Tomas, Liu, Mengling, Afanasyeva, Yelena, Andersson, Anne, Arslan, Alan A., Chen, Yu, Hallmans, Göran, Lenner, Per, Kirchhoff, Tomas, Lundin, Eva, Shore, Roy E., Sund, Malin, Zeleniuch-Jacquotte, Anne, Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Axelsson, Tomas, Liu, Mengling, Afanasyeva, Yelena, Andersson, Anne, Arslan, Alan A., Chen, Yu, Hallmans, Göran, Lenner, Per, Kirchhoff, Tomas, Lundin, Eva, Shore, Roy E., Sund, Malin, and Zeleniuch-Jacquotte, Anne

Abstract

Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH) D concentration in GWAS were also associated with plasma 25(OH) D in our study (p-trend < 0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH) D with breast cancer risk, do not support an association between vitamin D and breast cancer risk.

Published
2015
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49. Endogenous hormones in mid‐life and later‐life subjective memory impairment in women.

Author

Sharma, Sneha, Clendenen, Tess V, Wu, Fen, Afanasyeva, Yelena, Koenig, Karen L, Zeleniuch‐Jacquotte, Anne, and Chen, Yu

Abstract

Background: Reproductive hormones may impact cognition in women. Recent literature suggests that subjective memory complaints (SMCs) can be an early indicator of cognitive impairment. However, epidemiologic data are mixed, with few prospective studies exploring endogenous sex hormones in relation to later‐life SMCs. Assessing this potential association may elucidate an etiology of risk for cognitive impairment in women. Method: We included 616 premenopausal and 102 postmenopausal women from the New York University Women's Health Study (NYUWHS), a prospective cohort study with blood samples collected at enrollment (1985‐91) and over 35 years of follow‐up to collect health and lifestyle information. Women were ineligible for inclusion in the cohort if they used hormone medications or were pregnant 6 months prior to enrollment. Healthy controls from prior NYUWHS case‐control studies were eligible for participation in this study if their baseline blood sample had already been used to measure circulating hormones, and they responded to at least one of two follow‐up questionnaires (2018‐present) featuring 6 questions about SMCs. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of baseline hormones with subsequent SMCs, adjusting for age, race, education, original case‐control study, and body mass index (BMI) in a separate model. Result: Androstenedione, testosterone, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) were measured in samples collected at baseline for pre‐ and post‐menopausal women; estradiol and estrone were also measured in postmenopausal women. There were no significant associations between premenopausal circulating hormones or SHBG and SMCs. Postmenopausal hormones were inversely associated with SMCs, including in age and BMI‐adjusted models: ORs (95% CIs) for SMCs associated with doubling in testosterone and estradiol were 0.58 (0.35‐0.95) and 0.39 (0.17‐0.90), respectively. Conclusion: Higher postmenopausal concentrations of testosterone and estradiol are inversely associated with risk of later‐life SMCs in women. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study

Author

Clendenen, Tess V., primary, Ge, Wenzhen, additional, Koenig, Karen L., additional, Axelsson, Tomas, additional, Liu, Mengling, additional, Afanasyeva, Yelena, additional, Andersson, Anne, additional, Arslan, Alan A., additional, Chen, Yu, additional, Hallmans, Göran, additional, Lenner, Per, additional, Kirchhoff, Tomas, additional, Lundin, Eva, additional, Shore, Roy E., additional, Sund, Malin, additional, and Zeleniuch-Jacquotte, Anne, additional

Published
2015
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