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4. Chronic stress primes innate immune responses in mice and humans

Author

Barrett, Tessa J., Corr, Emma M., van Solingen, Coen, Schlamp, Florencia, Brown, Emily J., Koelwyn, Graeme J., Lee, Angela H., Shanley, Lianne C., Spruill, Tanya M., Bozal, Fazli, de Jong, Annika, Newman, Alexandra A.C., Drenkova, Kamelia, Silvestro, Michele, Ramkhelawon, Bhama, Reynolds, Harmony R., Hochman, Judith S., Nahrendorf, Matthias, Swirski, Filip K., Fisher, Edward A., Berger, Jeffrey S., and Moore, Kathryn J.

Published
2021
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5. Myocardial infarction accelerates breast cancer via innate immune reprogramming

Author

Koelwyn, Graeme J., Newman, Alexandra A.C., Afonso, Milessa S., van Solingen, Coen, Corr, Emma M., Brown, Emily J., Albers, Kathleen B., Yamaguchi, Naoko, Narke, Deven, Schlegel, Martin, Sharma, Monika, Shanley, Lianne C., Barrett, Tessa J., Rahman, Karishma, Mezzano, Valeria, Fisher, Edward A., Park, David S., Newman, Jonathan D., Quail, Daniela F., Nelson, Erik R., Caan, Bette J., Jones, Lee W., and Moore, Kathryn J.

Subjects
Complications and side effects, Models, Development and progression, Health aspects, Heart attack -- Models -- Complications and side effects, Immune response -- Health aspects, Breast cancer -- Models -- Development and progression
Abstract

Author(s): Graeme J. Koelwyn [sup.1] , Alexandra A. C. Newman [sup.1] , Milessa S. Afonso [sup.1] , Coen van Solingen [sup.1] , Emma M. Corr [sup.1] , Emily J. Brown [...], Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity.sup.1 or surgery.sup.2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors.sup.3-5. While elevated risk and incidence of cardiovascular events in breast cancer is well established, whether such events impact cancer pathogenesis is not known. Here we show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. In mouse models of breast cancer, MI epigenetically reprogrammed Ly6C.sup.hi monocytes in the bone marrow reservoir to an immunosuppressive phenotype that was maintained at the transcriptional level in monocytes in both the circulation and tumor. In parallel, MI increased circulating Ly6C.sup.hi monocyte levels and recruitment to tumors and depletion of these cells abrogated MI-induced tumor growth. Furthermore, patients with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis had increased risk of recurrence and cancer-specific death. These preclinical and clinical results demonstrate that MI induces alterations in systemic homeostasis, triggering cross-disease communication that accelerates breast cancer. By reprogramming innate immune cells to an immunosuppressive phenotype, myocardial infarction accelerates breast cancer progression in mice, and the clinical relevance of these findings was demonstrated in individuals with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis.

Published
2020
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7. Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID

Author

V.Gerayeli, Firoozeh, primary, Park, Hye Yun, additional, Milne, Stephen, additional, Li, Xuan, additional, Yang, Chen Xi, additional, Tuong, Josie, additional, Eddy, Rachel, additional, Guinto, Elizabeth, additional, Cheung, Chung Y, additional, Yang, Julia Shun-Wei, additional, Gilchrist, Cassie, additional, Yehia, Dina, additional, Stach, Tara, additional, Shaipanich, Tawimas, additional, Leipsic, Jonathon, additional, Koelwyn, Graeme, additional, Leung, Janice, additional, and Sin, Don D, additional

Published
2024
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11. The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Author

Hennessy, Elizabeth J., van Solingen, Coen, Scacalossi, Kaitlyn R., Ouimet, Mireille, Afonso, Milessa S., Prins, Jurrien, Koelwyn, Graeme J., Sharma, Monika, Ramkhelawon, Bhama, Carpenter, Susan, Busch, Albert, Chernogubova, Ekaterina, Matic, Ljubica Perisic, Hedin, Ulf, Maegdefessel, Lars, Caffrey, Brian E., Hussein, Maryem A., Ricci, Emiliano P., Temel, Ryan E., Garabedian, Michael J., Berger, Jeffrey S., Vickers, Kasey C., Kanke, Matthew, Sethupathy, Praveen, Teupser, Daniel, Holdt, Lesca M., and Moore, Kathryn J.

Published
2019
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15. Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition

Author

TRAN, KAREN C., primary, LEE, TERRY, additional, LEVIN, ADEERA, additional, RYERSON, CHRISTOPHER J., additional, WONG, ALYSON, additional, SWEET, DAVID, additional, WALLEY, KEITH R., additional, BOYD, JOHN H., additional, SINGER, JOEL, additional, KOELWYN, GRAEME J., additional, Sc, PUNEET MANN M, additional, Sc, KATHRYN DONOHOE B, additional, and Russell, James, additional

Published
2022
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17. The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells

Author

Ma, Liqian, primary, Vidana Gamage, Hashni Epa, additional, Tiwari, Srishti, additional, Han, Chaeyeon, additional, Henn, Madeline A, additional, Krawczynska, Natalia, additional, Dibaeinia, Payam, additional, Koelwyn, Graeme J, additional, Das Gupta, Anasuya, additional, Bautista Rivas, Rafael Ovidio, additional, Wright, Chris L, additional, Xu, Fangxiu, additional, Moore, Kathryn J, additional, Sinha, Saurabh, additional, and Nelson, Erik R, additional

Published
2022
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18. Inhaled Corticosteroids Selectively Alter the Microbiome and Host Transcriptome in the Small Airways of Patients with Chronic Obstructive Pulmonary Disease

Author

Yip, William, primary, Li, Xuan, additional, Koelwyn, Graeme J., additional, Milne, Stephen, additional, Leitao Filho, Fernando Sergio, additional, Yang, Chen Xi, additional, Hernández Cordero, Ana I., additional, Yang, Julia, additional, Yang, Cheng Wei Tony, additional, Shaipanich, Tawimas, additional, van Eeden, Stephan F., additional, Leung, Janice M., additional, Lam, Stephen, additional, McNagny, Kelly M., additional, and Sin, Don D., additional

Published
2022
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22. Abstract 105: Chronic Stress Primes Innate Immune Responses In Mice And Humans

Author

Barrett, Tessa J, primary, Corr, Emma, additional, Solingen, Coen, additional, Schlamp, Florencia, additional, Brown, Emily J, additional, KOELWYN, Graeme J, additional, Lee, Angela, additional, Shanley, Lianne, additional, Spruill, Tanya, additional, Bozal, Fazli, additional, De Jong, Annika, additional, Newman, Alexandra, additional, Drenkova, Kamelia, additional, Silvestro, Michele, additional, Rhamkhelawon, Bhama, additional, Reynolds, Harmony, additional, Hochman, Judith S, additional, Nahrendorf, Matthias, additional, Swirski, Filip K, additional, A Fisher, Edward A, additional, Berger, Jeffrey S, additional, and Moore, Kathryn J, additional

Published
2021
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23. miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

Author

Afonso, Milessa Silva, primary, Sharma, Monika, additional, Schlegel, Martin, additional, van Solingen, Coen, additional, Koelwyn, Graeme J., additional, Shanley, Lianne C., additional, Beckett, Lauren, additional, Peled, Daniel, additional, Rahman, Karishma, additional, Giannarelli, Chiara, additional, Li, Huilin, additional, Brown, Emily J., additional, Khodadadi-Jamayran, Alireza, additional, Fisher, Edward A., additional, and Moore, Kathryn J., additional

Published
2021
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25. Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells.

Author

Ma, Liqian, Gamage, Hashni Epa Vidana, Tiwari, Srishti, Han, Chaeyeon, Henn, Madeline A, Krawczynska, Natalia, Dibaeinia, Payam, Koelwyn, Graeme J, Gupta, Anasuya Das, Rivas, Rafael Ovidio Bautista, Wright, Chris L, Xu, Fangxiu, Moore, Kathryn J, Sinha, Saurabh, and Nelson, Erik R

Subjects
CHOLESTEROL, MYELOID cells, HOMEOSTASIS
Abstract

Dysregulation of cholesterol homeostasis is associated with many diseases such as cardiovascular disease and cancer. Liver X receptors (LXRs) are major upstream regulators of cholesterol homeostasis and are activated by endogenous cholesterol metabolites such as 27-hydroxycholesterol (27HC). LXRs and various LXR ligands such as 27HC have been described to influence several extra-hepatic biological systems. However, disparate reports of LXR function have emerged, especially with respect to immunology and cancer biology. This would suggest that, similar to steroid nuclear receptors, the LXRs can be selectively modulated by different ligands. Here, we use RNA-sequencing of macrophages and single-cell RNA-sequencing of immune cells from metastasis-bearing murine lungs to provide evidence that LXR satisfies the 2 principles of selective nuclear receptor modulation: (1) different LXR ligands result in overlapping but distinct gene expression profiles within the same cell type, and (2) the same LXR ligands differentially regulate gene expression in a highly context-specific manner, depending on the cell or tissue type. The concept that the LXRs can be selectively modulated provides the foundation for developing precision pharmacology LXR ligands that are tailored to promote those activities that are desirable (proimmune), but at the same time minimizing harmful side effects (such as elevated triglyceride levels). [ABSTRACT FROM AUTHOR]

Published
2022
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27. ENDOTHELIAL CELL-DERIVED EXTRACELLULAR VESICLES ELICIT NEUTROPHIL DEPLOYMENT FROM THE SPLEEN FOLLOWING ACUTE MYOCARDIAL INFARCTION

Author

Akbar, Naveed, primary, Braithwaite, Adam, additional, Corr, Emma, additional, Koelwyn, Graeme, additional, van Solingen, Coen, additional, Cochain, Clement, additional, Saliba, Antoine-Emmanuel, additional, Corbin, Alastair, additional, Pezzolla, Daniela, additional, Edgar, Laurienne, additional, Gunadasa-Rohling, Mala, additional, Banerjee, Abhirup, additional, Paget, Daan, additional, Lee, Charlotte, additional, Hogg, Eleanor, additional, Costin, Adam, additional, Dhaliwal, Raman, additional, Johnson, Errin, additional, Krausgruber, Thomas, additional, Riepsaame, Joey, additional, Melling, Genevieve, additional, Shanmuganathan, Mayooran, additional, Acute Myocardial Infarction Study, Oxford, additional, Bock, Christoph, additional, Carter, David, additional, Channon, Keith, additional, Riley, Paul, additional, Udalova, Irina, additional, Moore, Kathryn, additional, Anthony, Daniel, additional, and Choudhury, Robin, additional

Published
2020
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29. Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression

Author

Sharma, Monika, primary, Schlegel, Martin P., additional, Afonso, Milessa S., additional, Brown, Emily J., additional, Rahman, Karishma, additional, Weinstock, Ada, additional, Sansbury, Brian E., additional, Corr, Emma M., additional, van Solingen, Coen, additional, Koelwyn, Graeme J., additional, Shanley, Lianne C., additional, Beckett, Lauren, additional, Peled, Daniel, additional, Lafaille, Juan J., additional, Spite, Matthew, additional, Loke, P’ng, additional, Fisher, Edward A., additional, and Moore, Kathryn J., additional

Published
2020
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32. A framework for prescription in exercise-oncology research†

Author

Sasso, John P, Eves, Neil D, Christensen, Jesper F, Koelwyn, Graeme J, Scott, Jessica, and Jones, Lee W

Subjects
Editorials
Abstract

The field of exercise-oncology has increased dramatically over the past two decades, with close to 100 published studies investigating the efficacy of structured exercise training interventions in patients with cancer. Of interest, despite considerable differences in study population and primary study end point, the vast majority of studies have tested the efficacy of an exercise prescription that adhered to traditional guidelines consisting of either supervised or home-based endurance (aerobic) training or endurance training combined with resistance training, prescribed at a moderate intensity (50-75% of a predetermined physiological parameter, typically age-predicted heart rate maximum or reserve), for two to three sessions per week, for 10 to 60 min per exercise session, for 12 to 15 weeks. The use of generic exercise prescriptions may, however, be masking the full therapeutic potential of exercise treatment in the oncology setting. Against this background, this opinion paper provides an overview of the fundamental tenets of human exercise physiology known as the principles of training, with specific application of these principles in the design and conduct of clinical trials in exercise-oncology research. We contend that the application of these guidelines will ensure continued progress in the field while optimizing the safety and efficacy of exercise treatment following a cancer diagnosis.

Published
2015

33. Exercise in regulation of inflammation-immune axis function in cancer initiation and progression

Author

Koelwyn, Graeme J., Wennerberg, Erik, Demaria, Sandra, and Jones, Lee W.

Subjects
Care and treatment, Prevention, Complications and side effects, Development and progression, Research, Inflammation -- Care and treatment -- Research -- Complications and side effects, Cancer -- Development and progression -- Research -- Prevention
Abstract

Introduction Over the past 2 decades, a steadily growing and increasingly diverse evidence base has emerged investigating the tolerability and initial efficacy of general physical activity, as well as of [...], Pharmacologic manipulation of the immune system is emerging as a viable and robust treatment for some cancer patients. Exercise-induced modulation of the immune system may be another adjunctive strategy for inhibiting tumor initiation and progression. In healthy individuals, exercise has been shown to modulate a number of cell subsets involved in innate and adaptive immunity. Here, we provide an overview of the current state of knowledge pertaining to exercise modulation of the inflammation-immune axis in cancer. The current evidence suggests that exercise may be a promising adjunctive strategy that can favorably alter numerous components of the immune system, which, in turn, may modulate tumorigenesis. However, many important knowledge gaps are evident. To this end, we propose a framework to guide future research efforts investigating the immune effects of exercise in cancer.

Published
2015

34. The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Author

Hennessy, Elizabeth J., primary, van Solingen, Coen, additional, Scacalossi, Kaitlyn R., additional, Ouimet, Mireille, additional, Afonso, Milessa S., additional, Prins, Jurrien, additional, Koelwyn, Graeme J., additional, Sharma, Monika, additional, Ramkhelawon, Bhama, additional, Carpenter, Susan, additional, Busch, Albert, additional, Chernogubova, Ekaterina, additional, Matic, Ljubica Perisic, additional, Hedin, Ulf, additional, Maegdefessel, Lars, additional, Caffrey, Brian E., additional, Hussein, Maryem A., additional, Ricci, Emiliano P., additional, Temel, Ryan E., additional, Garabedian, Michael J., additional, Berger, Jeffrey S., additional, Vickers, Kasey C., additional, Kanke, Matthew, additional, Sethupathy, Praveen, additional, Teupser, Daniel, additional, Holdt, Lesca M., additional, and Moore, Kathryn J., additional

Published
2018
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35. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis

Author

Scott, Jessica M., primary, Zabor, Emily C., additional, Schwitzer, Emily, additional, Koelwyn, Graeme J., additional, Adams, Scott C., additional, Nilsen, Tormod S., additional, Moskowitz, Chaya S., additional, Matsoukas, Konstantina, additional, Iyengar, Neil M., additional, Dang, Chau T., additional, and Jones, Lee W., additional

Published
2018
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38. Abstract 190: Mir-33 Inhibition Alters Monocyte/macrophage Kinetic Processes to Promote Atherosclerotic Plaque Regression

Author

Afonso, Milessa S, primary, Sharma, Monika, additional, van Solingen, Coen, additional, Koelwyn, Graeme J, additional, Schlegel, P. Martin, additional, Ouimet, Mireille, additional, Beckett, Lauren, additional, Babunovic, Susan, additional, Rahman, Karishma, additional, Fisher, Edward A, additional, and Moore, Kathryn J, additional

Published
2018
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39. miRNA Targeting of Oxysterol Binding Protein-like 6 (OSBPL6) Regulates Cholesterol Trafficking and Efflux

Author

Ouimet, Mireille, Hennessy, Elizabeth J., van Solingen, Coen, Koelwyn, Graeme J., Hussein, Maryem A., Ramkhelawon, Bhama, Rayner, Katey J., Temel, Ryan E., Perisic, Ljubica, Hedin, Ulf, Maegdefessel, Lars, Garabedian, Michael J., Holdt, Lesca M., Teupser, Daniel, and Moore, Kathryn J.

Subjects
Male, Receptors, Steroid, Transcription, Genetic, Endoplasmic Reticulum, Transfection, Article, Chlorocebus aethiops, Animals, Humans, 3' Untranslated Regions, Liver X Receptors, Mice, Knockout, Binding Sites, Macrophages, Cholesterol, HDL, Biological Transport, Hep G2 Cells, Atherosclerosis, Plaque, Atherosclerotic, Mice, Inbred C57BL, Disease Models, Animal, MicroRNAs, Cholesterol, HEK293 Cells, Receptors, LDL, Hepatocytes, RNA Interference, ATP Binding Cassette Transporter 1, Protein Binding
Abstract

Cholesterol homeostasis is fundamental to human health and is, thus, tightly regulated. MicroRNAs exert potent effects on biological pathways, including cholesterol metabolism, by repressing genes with related functions. We reasoned that this mode of pathway regulation could be exploited to identify novel genes involved in cholesterol homeostasis.Here, we identify oxysterol-binding protein-like 6 (OSBPL6) as a novel target of 2 miRNA hubs regulating cholesterol homeostasis: miR-33 and miR-27b. Characterization of OSBPL6 revealed that it is transcriptionally regulated in macrophages and hepatocytes by liver X receptor and in response to cholesterol loading and in mice and nonhuman primates by Western diet feeding. OSBPL6 encodes the OSBPL-related protein 6 (ORP6), which contains dual membrane- and endoplasmic reticulum-targeting motifs. Subcellular localization studies showed that ORP6 is associated with the endolysosomal network and endoplasmic reticulum, suggesting a role for ORP6 in cholesterol trafficking between these compartments. Accordingly, knockdown of OSBPL6 results in aberrant clustering of endosomes and promotes the accumulation of free cholesterol in these structures, resulting in reduced cholesterol esterification at the endoplasmic reticulum. Conversely, ORP6 overexpression enhances cholesterol trafficking and efflux in macrophages and hepatocytes. Moreover, we show that hepatic expression of OSBPL6 is positively correlated with plasma levels of high-density lipoprotein cholesterol in a cohort of 200 healthy individuals, whereas its expression is reduced in human atherosclerotic plaques.These studies identify ORP6 as a novel regulator of cholesterol trafficking that is part of the miR-33 and miR-27b target gene networks that contribute to the maintenance of cholesterol homeostasis.

Published
2016

41. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Author

Althammer, Sonja, primary, Steele, Keith, additional, Rebelatto, Marlon, additional, Tan, Tze Heng, additional, Wiestler, Tobias, additional, Schmidt, Guenter, additional, Higgs, Brandon, additional, Li, Xia, additional, Shi, Li, additional, Jin, Xiaoping, additional, Antal, Joyce, additional, Gupta, Ashok, additional, Ranade, Koustubh, additional, Binning, Gerd, additional, Bellmunt, Joaquim, additional, de Wit, Ronald, additional, Vaughn, David J., additional, Fradet, Yves, additional, Lee, Jae Lyun, additional, Fong, Lawrence, additional, Vogelzang, Nicholas J., additional, Climent, Miguel A., additional, Petrylak, Daniel P., additional, Choueiri, Toni K., additional, Necchi, Andrea, additional, Gerritsen, Winald, additional, Gurney, Howard, additional, Quinn, David I., additional, Culine, Stéphane, additional, Sternberg, Cora N., additional, Mai, Yabing, additional, Puhlmann, Markus, additional, Perini, Rodolfo F., additional, Bajorin, Dean F., additional, Sharma, Padmanee, additional, Callahan, Margaret K., additional, Calvo, Emiliano, additional, Kim, Joseph W., additional, de Braud, Filipo, additional, Ott, Patrick A., additional, Bono, Petri, additional, Pillai, Rathi N., additional, Morse, Michael, additional, Le, Dung T., additional, Taylor, Matthew, additional, Spilliopoulou, Pavlina, additional, Bendell, Johanna, additional, Jaeger, Dirk, additional, Chan, Emily, additional, Antonia, Scott J., additional, Ascierto, Paolo A., additional, Hennicken, Delphine, additional, Tschaika, Marina, additional, Azrilevich, Alex, additional, Rosenberg, Jonathan, additional, Levy, Ofer, additional, Chan, Christopher, additional, Cojocaru, Gady, additional, Liang, Spencer, additional, Ophir, Eran, additional, Ganguly, Sudipto, additional, Toporik, Amir, additional, Kotturi, Maya, additional, Kfir, Tal Fridman, additional, Murter, Benjamin M., additional, Logronio, Kathryn, additional, Dassa, Liat, additional, Leung, Ling, additional, Greenwald, Shirley, additional, Azulay, Meir, additional, Kumar, Sandeep, additional, Alteber, Zoya, additional, Pan, Xiaoyu, additional, Machlenkin, Arthur, additional, Benita, Yair, additional, Drake, Andrew W., additional, Chajut, Ayelet, additional, Salomon, Ran, additional, Vankin, Ilan, additional, Safyon, Einav, additional, Hunter, John, additional, Levine, Zurit, additional, White, Mark, additional, Leidner, Rom, additional, Kang, Hyunseok, additional, Haddad, Robert, additional, Segal, Neil H., additional, Wirth, Lori J., additional, Ferris, Robert L., additional, Hodi, F. Stephen, additional, Sanborn, Rachel E., additional, Gajewski, Thomas F., additional, Sharfman, William, additional, McDonald, Dan, additional, Srivastava, Shivani, additional, Gu, Xuemin, additional, Phillips, Penny, additional, Passey, Chaitali, additional, Seiwert, Tanguy, additional, Habtetsion, Tsadik, additional, Zhou, Gang, additional, Sakellariou-Thompson, Donastas, additional, Haymaker, Cara, additional, Creasy, Caitlin, additional, Hurd, Mark, additional, Uraoka, Naohiro, additional, Canales, Jaime Rodriguez, additional, Koptez, Scott, additional, Hwu, Patrick, additional, Maitra, Anirban, additional, Bernatchez, Chantale, additional, Coyle, Scott M., additional, Roybel, Kole T., additional, Rupp, Levi J., additional, Santoro, Stephen P., additional, Secrest, Stephanie, additional, Spelman, Michael, additional, Ho, Hanson, additional, Gomes, Tina, additional, Tse, Tiffany, additional, Yung-Wu, Chia, additional, Taunton, Jack, additional, Lim, Wendell, additional, Emtage, Peter, additional, Moudgil, Tarsem, additional, Ballesteros-Merino, Carmen, additional, Hilton, Traci, additional, Paustian, Christopher, additional, Page, David, additional, Urba, Walter, additional, Fox, Bernard, additional, Bell, Bryan, additional, Patel, Ashish, additional, Olafsen, Tove, additional, Satpayev, Daulet, additional, Torgov, Michael, additional, Marchioni, Filippo, additional, Romero, Jason, additional, Jiang, Ziyue Karen, additional, Zamilpa, Charles, additional, Keppler, Jennifer S., additional, Mascioni, Alessandro, additional, Jia, Fang, additional, Lee, Chen-Yu, additional, Gudas, Jean, additional, Sullivan, Ryan J., additional, Hoshida, Yujin, additional, Logan, Theodore, additional, Khushalani, Nikhil, additional, Giobbie-Hurder, Anita, additional, Margolin, Kim, additional, Roder, Joanna, additional, Bhatt, Rupal, additional, Koon, Henry, additional, Olencki, Thomas, additional, Hutson, Thomas, additional, Curti, Brendan, additional, Blackmon, Shauna, additional, Mier, James W., additional, Puzanov, Igor, additional, Roder, Heinrich, additional, Stewart, John, additional, Amin, Asim, additional, Ernstoff, Marc S., additional, Clark, Joseph I., additional, Atkins, Michael B., additional, Kaufman, Howard L., additional, Sosman, Jeffrey, additional, Signoretti, Sabina, additional, McDermott, David F., additional, Anderson, Abraham A., additional, Milhem, Mohammed M., additional, Andtbacka, Robert H. I., additional, Minor, David, additional, Gorski, Kevin S., additional, Baker, Daniel M., additional, Hamid, Omid, additional, Akporiaye, Emmanuel, additional, Koguchi, Yoshinobu, additional, Sutcliffe, Kim, additional, Conder, Kristie, additional, Marron, Thomas, additional, Bhardwaj, Nina, additional, Hammerich, Linda, additional, George, Fiby, additional, Kim-Schulze, Seunghee, additional, Keler, Tibor, additional, Davis, Tom, additional, Crowley, Elizabeth, additional, Salazar, Andres, additional, Brody, Joshua, additional, Monjazeb, Arta, additional, Daly, Megan E., additional, Riess, Jonathan, additional, Li, Tianhong, additional, Murphy, William J., additional, Kelly, Karen, additional, Hu, Zhiwei, additional, Shen, Rulong, additional, Campbell, Amanda, additional, McMichael, Elizabeth, additional, Yu, Lianbo, additional, Ramaswam, Bhuvaneswari, additional, London, Cheryl A., additional, Xu, Tian, additional, Carson, William, additional, Kokolus, Kathleen M., additional, Repasky, Elizabeth A., additional, Schell, Todd D., additional, Drabick, Joseph D., additional, Messenheimer, David J., additional, Jensen, Shawn, additional, Rubinstein, Mark, additional, Andrijauskaite, Kristina, additional, Swiderska-syn, Marzena, additional, Lind, Kristin, additional, Choppin, Agnes, additional, Roell, Marina K., additional, Wrangle, John, additional, Rhode, Peter, additional, Wong, Hing, additional, Ahmad, Shamim, additional, Webb, Mason, additional, Abu-Eid, Rasha, additional, Shrimali, Rajeev, additional, Verma, Vivek, additional, Doroodchi, Atbin, additional, Berrong, Zuzana, additional, Yashar, David, additional, Samara, Raed, additional, Mkrtichyan, Mikayel, additional, Khleif, Samir, additional, Powell, Steven, additional, Gitau, Mark, additional, Sumey, Christopher, additional, Terrell, Andrew, additional, Lohr, Michele, additional, Nowak, Ryan K., additional, McGraw, Steven, additional, Jensen, Ash, additional, Blanchard, Miran, additional, Gold, Kathryn A., additional, Cohen, Ezra E. W., additional, Ellison, Christie, additional, Black, Lora, additional, Lee, John, additional, Spanos, William Chad, additional, Wennerberg, Erik, additional, Schwitzer, Emily, additional, Lhuillier, Claire, additional, Koelwyn, Graeme, additional, Hiner, Rebecca, additional, Jones, Lee, additional, Demaria, Sandra, additional, Amanda, Vandeveer, additional, Greiner, John W., additional, Schlom, Jeffrey, additional, Bookstaver, Michelle, additional, Jewell, Christopher M., additional, Gunderson, Andrew, additional, Boulmay, Brian, additional, Li, Rui, additional, Spieler, Bradley, additional, Happel, Kyle, additional, Feng, Zipei, additional, Dubay, Christopher, additional, Fisher, Brenda, additional, Aung, Sandra, additional, Mederos, Eileen, additional, Bifulco, Carlo B., additional, McNamara, Michael, additional, Bahjat, Keith, additional, Redmond, William, additional, Ochoa, Augusto, additional, Hu, Hong-Ming, additional, Mehta, Adi, additional, Lund-Johansen, Fridtjof, additional, Bedu-Addo, Frank, additional, Conn, Greg, additional, King, Michael, additional, Dutta, Panna, additional, Shepard, Robert, additional, Einstein, Mark, additional, Adams, Sylvia, additional, Wang, Ena, additional, Jin, Ping, additional, Novik, Yelena, additional, Morrison, Debra, additional, Oratz, Ruth, additional, Marincola, Franco M., additional, Stroncek, David, additional, Goldberg, Judith, additional, Formenti, Silvia C., additional, Galon, Jérôme, additional, Mlecnik, Bernhard, additional, Marliot, Florence, additional, Ou, Fang-Shu, additional, Lugli, Alessandro, additional, Zlobec, Inti, additional, Rau, Tilman T., additional, Nagtegaal, Iris D., additional, Vink-Borger, Elisa, additional, Hartmann, Arndt, additional, Geppert, Carol, additional, Roehrl, Michael H., additional, Bavi, Prashant, additional, Ohashi, Pamela S., additional, Wang, Julia Y., additional, Nguyen, Linh T., additional, Han, SeongJun, additional, MacGregor, Heather L., additional, Hafezi-Bakhtiari, Sara, additional, Wouters, Bradley G., additional, Kawakami, Yutaka, additional, Papivanova, Boryana, additional, Xu, Mingli, additional, Fujita, Tomonobu, additional, Hazama, Shoichi, additional, Suzuki, Nobuaki, additional, Nagano, Hiroaki, additional, Okuno, Kiyotaka, additional, Itoh, Kyogo, additional, Zavadova, Eva, additional, Vocka, Michal, additional, Spacek, Jan, additional, Petruzelka, Lubos, additional, Konopasek, Bohuslav, additional, Dundr, Pavel, additional, Skalova, Helena, additional, Torigoe, Toshihiko, additional, Sato, Noriyuki, additional, Furuhata, Tomohisa, additional, Takemasa, Ichiro, additional, Van den Eynde, Marc, additional, Jouret-Mourin, Anne, additional, Machiels, Jean-Pascal, additional, Fredriksen, Tessa, additional, Lafontaine, Lucie, additional, Buttard, Bénédicte, additional, Church, Sarah, additional, Maby, Pauline, additional, Angell, Helen, additional, Angelova, Mihaela, additional, Vasaturo, Angela, additional, Bindea, Gabriela, additional, Berger, Anne, additional, Lagorce, Christine, additional, Patel, Prabhu S., additional, Vora, Hemangini H., additional, Shah, Birva, additional, Patel, Jayendrakumar B., additional, Rajvik, Kruti N., additional, Pandya, Shashank J., additional, Shukla, Shilin N., additional, Wang, Yili, additional, Zhang, Guanjun, additional, Masucci, Giuseppe V., additional, Andersson, Emilia K., additional, Grizzi, Fabio, additional, Laghi, Luigi, additional, Botti, Gerardo, additional, Tatangelo, Fabiana, additional, Delrio, Paolo, additional, Cilberto, Gennaro, additional, Marincola, Franco, additional, Sargent, Daniel J., additional, Fox, Bernard A., additional, Algazi, Alain, additional, Tsai, Katy, additional, Rosenblum, Michael, additional, Nandoskar, Prachi, additional, Li, Amy, additional, Nonomura, John, additional, Takamura, Kathryn, additional, Dwyer, Mary, additional, Browning, Erica, additional, Talia, Reneta, additional, Twitty, Chris, additional, Gargosky, Sharron, additional, Campbell, Jean, additional, Le, Mai, additional, Pierce, Robert H., additional, Daud, Adil, additional, Gartrell, Robyn, additional, Marks, Douglas, additional, Stack, Edward, additional, Lu, Yan, additional, Izaki, Daisuke, additional, Beck, Kristen, additional, Jia, Dan Tong, additional, Armenta, Paul, additional, White-Stern, Ashley, additional, Fu, Yichun, additional, Blake, Zoe, additional, Taback, Bret, additional, Horst, Basil, additional, Saenger, Yvonne M., additional, Leonardo, Steven, additional, Gorden, Keith, additional, Fulton, Ross B., additional, Fraser, Kathryn, additional, Kangas, Takashi O., additional, Walsh, Richard, additional, Ertelt, Kathleen, additional, Graff, Jeremy, additional, Uhlik, Mark, additional, Sims, Jennifer S., additional, Lei, Liang, additional, Tsujiuchi, Takashi, additional, Bruce, Jeffrey N., additional, Canoll, Peter, additional, Tolcher, Anthony W, additional, Alley, Evan W, additional, Chichili, Gurunadh, additional, Canoll, Jan E, additional, Moore, Paul, additional, Bonvini, Ezio, additional, Johnson, Syd, additional, Shankar, Sadhna, additional, Vasselli, James, additional, Wigginton, Jon, additional, and Powderly, John, additional

Published
2016
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42. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux

Author

Ouimet, Mireille, primary, Hennessy, Elizabeth J., additional, van Solingen, Coen, additional, Koelwyn, Graeme J., additional, Hussein, Maryem A., additional, Ramkhelawon, Bhama, additional, Rayner, Katey J., additional, Temel, Ryan E., additional, Perisic, Ljubica, additional, Hedin, Ulf, additional, Maegdefessel, Lars, additional, Garabedian, Michael J., additional, Holdt, Lesca M., additional, Teupser, Daniel, additional, and Moore, Kathryn J., additional

Published
2016
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43. Abstract 402: miRNA Targeting of Oxysterol Binding Protein-like 6 (OSBPL6) Regulates Cholesterol Trafficking and Efflux

Author

Ouimet, Mireille, primary, Hennessy, Elizabeth, additional, Koelwyn, Graeme, additional, van Solingen, Coen, additional, Hussein, Maryem, additional, Ramkhelawon, Bhama, additional, Rayner, Katey, additional, Garabedian, Michael, additional, Temel, Ryan, additional, Holdt, Lesca, additional, Tupser, Daniel, additional, and Moore, Kathryn, additional

Published
2016
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45. Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy

Author

Koelwyn, Graeme J., primary, Lewis, Nia C., additional, Ellard, Susan L., additional, Jones, Lee W., additional, Gelinas, Jinelle C., additional, Rolf, J. Douglass, additional, Melzer, Bernie, additional, Thomas, Samantha M., additional, Douglas, Pamela S., additional, Khouri, Michel G., additional, and Eves, Neil D., additional

Published
2016
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48. Ventricular arterial coupling in early breast cancer patients following treatment with anthracycline-containing adjuvant chemotherapy.

Author

Koelwyn, Graeme J, primary, Lewis, Nia C, additional, Ellard, Susan, additional, Jones, Lee, additional, Gelinas, Jinelle C, additional, Rolf, Douglass J, additional, Melzer, Bernie, additional, Thomas, Samantha, additional, Douglas, Pamela S., additional, Khouri, Michel, additional, and Eves, Neil D, additional

Published
2014
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