12 results on '"Kocik, L."'
Search Results
2. PO-1473 Effectiveness and tolerability of SARS-CoV-2 vaccination in patients undergoing radiotherapy
- Author
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Geinitz, H., primary, Silberberger, E., additional, Spiegl, K., additional, Feichtinger, J., additional, Track, C., additional, Weis, E., additional, Venhoda, C., additional, Huppert, R., additional, Bräutigam, E., additional, Aschacher, B., additional, Kocik, L., additional, Karasek, N., additional, Fischerlehner, B., additional, Gruber, G., additional, Bihary, D.V., additional, Erdei, M., additional, Kirchner, K., additional, Zauner-Barbor, G., additional, Ecker, M., additional, Spindelbalker-Renner, B., additional, Adler, R., additional, Thöne, P., additional, and Dieplinger, B., additional
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- 2022
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3. Short-Course Hyperfractionated Accelerated Radiation Therapy (SC-HART) for Rectal Cancer Stage UICC II – III (8th Edition). Results from a Single Austrian Institution
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Kocik, L., primary, Track, C., additional, Feichtinger, J., additional, Kaufmann, J., additional, Hammer, J., additional, and Geinitz, H., additional
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- 2018
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4. Feasibility of radiotherapy in nonagenarian patients: a retrospective study
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Kocik, L., primary, Geinitz, H., additional, Track, C., additional, Geier, M., additional, and Nieder, C., additional
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- 2018
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5. Strahlentherapie bei „Nonagenerians“: eine retrospektive Machbarkeitsstudie.
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Kocik, L., Geinitz, H., Track, C., Geier, M., and Nieder, C.
- Subjects
AGE distribution ,GERIATRIC assessment ,COMBINED modality therapy ,LONGITUDINAL method ,PALLIATIVE treatment ,RADIOTHERAPY ,SURVIVAL ,TUMORS ,PILOT projects ,KAPLAN-Meier estimator - Abstract
Purpose: Specific information about radiation therapy in nonagenarians is limited. In order to shed more light on the feasibility of radiotherapy in this challenging subgroup, a retrospective study was performed.Methods: The data of 93 consecutive patients receiving irradiation treatment at the Department of Radiation Oncology, Ordensklinikum Linz Barmherzige Schwestern between June 2005 and December 2016 were analyzed. Patient- and treatment-related factors were extracted from the patient records. Overall survival (OS) was defined as time from irradiation to death or last follow-up. The survival rates were analyzed using the Kaplan-Meier method and log-rank test.Results: The study population of 93 patients was between 90 and 99 years old (median 91 years). It included 59 women (63%) and 34 men (37%). Of these, 38 (41%) received definitive radiotherapy, 14 (15%) received neoadjuvant or adjuvant radiotherapy, whereas a palliative regimen was prescribed in 44% of the cases (n = 41). In all, 79 patients (85%) were able to complete their prescribed course of radiotherapy. While 16 (17%) patients reported grade 2 toxicities or higher, 4 had ≥grade 3 side effects (4%). The median survival was significantly higher in patients treated with adjuvant, neoadjuvant or definitive radiotherapy (13.8 months) compared to patients treated with palliative radiotherapy (3.6 months; p < 0.001).Conclusion: Even in patients managed without preradiotherapy comprehensive geriatric assessment, carefully planned fractionated radiotherapy was feasible and resulted in acceptable rates of acute toxicities. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. De-intensification of postoperative radiotherapy in head and neck cancer irrespective of human papillomavirus status-results of a prospective multicenter phase II trial (DIREKHT Trial).
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Haderlein M, von der Grün J, Balermpas P, Rödel C, Hautmann MG, Steger F, Bohr C, Hehr T, Stromberger C, Budach V, Schymalla M, Engenhart-Cabillic R, Kocik L, Geinitz H, Nestle U, Klautke G, Scherl C, Gall C, Frey B, Schubert P, Semrau S, Ott O, Kesting M, Iro H, Mueller SK, and Fietkau R
- Abstract
Background: Current standard treatment concepts in head and neck squamous cell carcinoma (HNSCC) are based on former studies using 2D and 3D treatment plans. However, modern radiation techniques allow for a more precise and individual dose application. Therefore, in a clearly defined patient population, de-intensified risk-adapted radiation is investigated., Methods: Patients with newly diagnosed HNSCC after surgery (with resection margins ≥1 mm and cM0) with the following tumor stages (TNM 7th Edition) were eligible for the study: oral cavity, oropharynx, or larynx: pT1-3, pN0-pN2b; hypopharynx: pT1-2, pN1. The patients should have either a low risk of local recurrence [≤pT2, resection margin ≥5 mm, no peritumoral lymphangiosis (L0), and no perineural invasion] or contralateral lymph node metastasis (≤3 ipsilateral lymph node metastases, in case of well-lateralized oropharyngeal or oral cavity cancer contralateral cN0, otherwise pN0). Patients were assigned to three different treatment regimes with reduction of the treated volume, radiation dose, or both, according to tumor stage and results of surgery performed. The primary objective was to show an LRR of <10% after 2 years., Findings: A total of 150 patients were enrolled. Tumor localizations were as follows: n = 53 (35.3%), oral cavity; n = 94 (62.7%), oropharynx (82% HPV-positive); n = 2 (1.3%), hypopharynx; and n = 1 (0.7%), larynx. A total of 61 patients (41.0%) were stage IVA, 81 (54.0%) were stage III, and 8 (5.3%) were stage II. Median follow-up was 36 months. Cumulative incidence of 2y-LRR was 5.6% (95% CI: 1.7%-9.2%) in the whole study population and 14.1% (95% CI: 3.8%-23.2%) in patients with oral cavity cancer. Cumulative incidence of 2y-LRR in non-irradiated or dose-reduced regions was 3.5% (95% CI: 0.4%-6.5%). After 2 years, disease-free survival was 92% (95% CI: 87%-96%) and overall survival was 94% (95% CI: 90%-98%) for the complete study cohort. Acute III° toxicity was as follows: dysphagia, 30%; xerostomia, 7%; mucositis, 19%; and dermatitis, 4%. Dysphagia and xerostomia decrease over time. After 27 months, late dysphagia III° and xerostomia II° were 1% and 9%, respectively., Interpretation: The study met its primary objective. De-intensification of postoperative radiotherapy irrespective of HPV status in a predefined patient population is associated with a favorable toxicity profile without compromising LRR. In an unplanned subgroup analysis, a significantly increased risk of LRR was observed in patients with oral cavity cancer. In these patients, de-intensified radiotherapy should be applied with caution., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Haderlein, von der Grün, Balermpas, Rödel, Hautmann, Steger, Bohr, Hehr, Stromberger, Budach, Schymalla, Engenhart-Cabillic, Kocik, Geinitz, Nestle, Klautke, Scherl, Gall, Frey, Schubert, Semrau, Ott, Kesting, Iro, Mueller and Fietkau.)
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- 2024
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7. Immunogenicity Parameters of Cancer Patients Receiving the mRNA Vaccine BNT162b2 While Obtaining Radiotherapy: A Longitudinal Cohort Evaluation.
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Thöne P, Egger M, Geroldinger-Simic M, Kindermann H, Kocik L, Karasek N, Fischerlehner B, Spiegl K, Gruber G, Aschacher B, Dieplinger B, Clodi M, and Geinitz H
- Abstract
Background: Cancer patients are highly prone to infectious diseases. While undergoing antineoplastic treatment, the risk of severe symptoms upon infection increases, necessitating efficient protective measures, such as vaccination. For patients receiving radiotherapy, there is no specific information about humoral immunity. During the COVID-19 pandemic, serial antibody measurements were therefore offered to cancer patients, following SARS-CoV-2 vaccination while obtaining radiotherapy., Methods: Out of 74 enrolled patients, 46 met the inclusion criteria. Two cohorts were allocated, depending on an association with chemotherapy or pure radiotherapy. An additional healthy control cohort of 16 healthcare workers was enrolled. All participants followed a two-fold BNT162b2 vaccine schedule. SARS-CoV-2 binding antibodies were measured serially in a 7-day cycle for 35 days and over the long-term, using the Elecsys
® Anti-SARS-CoV-2 immunoassay., Results: Cancer patients under pure radiotherapy have a comparable humoral vaccination response and long-term persistency of antibodies to healthy controls. Patients receiving additional chemotherapy show a significantly delayed immune response and decreased antibody titers. The vaccine was well tolerated in all cohorts., Conclusions: Pure radiotherapy in cancer patients does not interfere with the vaccine-induced humoral immune response or other immunogenetic aspects, whereas previous or simultaneous chemotherapy does. Findings are of particular relevance for future epidemic or pandemic scenarios.- Published
- 2024
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8. Altered fractionation short-course radiotherapy for stage II-III rectal cancer: a retrospective study.
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Geinitz H, Nieder C, Kocik L, Track C, Feichtinger J, Weingartner T, Spiegl K, Füreder-Kitzmüller B, Kaufmann J, Seewald DH, Függer R, Shamiyeh A, Petzer AL, Kiesl D, and Hammer J
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- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoadjuvant Therapy methods, Neoadjuvant Therapy mortality, Neoplasm Recurrence, Local epidemiology, Radiotherapy, Adjuvant mortality, Rectal Neoplasms mortality, Retrospective Studies, Treatment Outcome, Dose Fractionation, Radiation, Radiotherapy, Adjuvant methods, Rectal Neoplasms radiotherapy
- Abstract
Purpose: To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer., Patients and Methods: This was a retrospective single institution study with median follow-up of 101 months (8.4 years). Patients who were alive at the time of analysis in 2018 were contacted to obtain functional outcome data (phone interview). Radiotherapy consisted of 25 Gy in 10 fractions of 2.5 Gy administered twice daily. Median time interval to surgery was 5 days., Results: Local relapse was observed in 12 patients (4.4%) after a median of 28 months. Overall survival after 5 and 10 years was 73 and 55.5%, respectively (corresponding disease-free survival 65.5 and 51%). Of all patients without permanent stoma, 79% reported no low anterior resection syndrome (LARS; 0-20 points), 9% reported LARS with 21-29 points and 12% serious LARS (30-42 points)., Conclusion: The present radiotherapy regimen was feasible and resulted in low rates of local relapse. Most patients reported good functional outcomes.
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- 2020
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9. Orientation of internal signal-anchor sequences at the Sec61 translocon.
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Kocik L, Junne T, and Spiess M
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- Animals, COS Cells, Chlorocebus aethiops, Models, Biological, Protein Transport, SEC Translocation Channels, Membrane Proteins chemistry, Membrane Proteins metabolism, Protein Sorting Signals
- Abstract
Translocation and insertion of secretory and membrane proteins at the endoplasmic reticulum are mediated by the Sec61 translocon. Evidence from in vivo as well as in vitro experiments indicates that N-terminal signal-anchor sequences initially insert N-first before they invert their orientation to translocate the C-terminus. Inversion is driven by flanking charges according to the positive-inside rule and inhibited by increased signal hydrophobicity. Here, we show that upon extending the N-terminal hydrophilic domain preceding the signal core to more than ~20 residues, the insertion behavior changes. Apparent signal inversion and the effect of hydrophobicity are largely lost, suggesting that N-first insertion is limited to N-terminal signal anchors. Extended N-domains sterically hinder N-translocation in a length-dependent manner also for reverse signal anchors with inverted flanking charges. The results indicate a mechanistic difference in the insertion process of N-terminal and internal signal sequences., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
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- 2012
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10. The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration.
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Junne T, Kocik L, and Spiess M
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- Amino Acids analysis, Amino Acids genetics, Amino Acids metabolism, Animals, Aspartic Acid analysis, Aspartic Acid genetics, Aspartic Acid metabolism, Base Sequence, Cellular Structures metabolism, Endoplasmic Reticulum, Rough genetics, Endoplasmic Reticulum, Rough metabolism, Hydrophobic and Hydrophilic Interactions, Lipid Bilayers analysis, Lipid Bilayers metabolism, Membranes metabolism, Mutation, Protein Transport genetics, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Virion genetics, Virion metabolism, Endoplasmic Reticulum chemistry, Endoplasmic Reticulum metabolism
- Abstract
The Sec61 translocon mediates the translocation of proteins across the endoplasmic reticulum membrane and the lateral integration of transmembrane segments into the lipid bilayer. The structure of the idle translocon is closed by a lumenal plug domain and a hydrophobic constriction ring. To test the function of the apolar constriction, we have mutated all six ring residues of yeast Sec61p to more hydrophilic, bulky, or even charged amino acids (alanines, glycines, serines, tryptophans, lysines, or aspartates). The translocon was found to be surprisingly tolerant even to the charge mutations in the constriction ring, because growth and translocation efficiency were not drastically affected. Most interestingly, ring mutants were found to affect the integration of hydrophobic sequences into the lipid bilayer, indicating that the translocon does not simply catalyze the partitioning of potential transmembrane segments between an aqueous environment and the lipid bilayer but that it also plays an active role in setting the hydrophobicity threshold for membrane integration.
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- 2010
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11. [Injuries of the peripheral blood vessels].
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Kocik L and Crnjakovic D
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- Erythromycin therapeutic use, Heparin therapeutic use, Humans, Postoperative Complications prevention & control, Suture Techniques, Vascular Surgical Procedures, Blood Vessels injuries
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Success in surgical intervention depends primarily on the general practicioner who makes the early diagnosis, who also makes the temporary bandages against clotting and who quickly transports the patient to the nearest surgical hospital. The arrival of patient in the shortest time period; within 6 hours after the injury, could give a guarantee for a successful surgical intervention. At a combined injury of veins and arteries, it is necessary to give, besides the minuteness surgical technic, an anti-coagulative (anti-clotting therapy during the post-operative period. We are of the opinion that every surgical department should be able to handle injuries on the outer blood vessels, which means they should have a good knowledge of basic principles on the vascular surgery.
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- 1976
12. [Our views and experience with 80 thromboendarterectomies].
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Kocik L, Crnjaković D, and Vukov J
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- Adult, Aged, Female, Femoral Artery surgery, Humans, Iliac Artery surgery, Leg blood supply, Male, Middle Aged, Popliteal Artery surgery, Endarterectomy, Thrombosis surgery
- Abstract
In three years' period 80 trombendarteriotomies on iliacae and femoralis arteris were made in our department. The decision for surgical measures was made on the basis of clinical state as well as aorto--graphies. With us, the basic principal of obliteration removing, was the initial gangren extremities and stronger rest pains. Analyzing our results we found out that 60 per cent of patients were good and in the 6 per cent cases the surgical measures didn't give the expected result. The aim of this exposition is to represent the way of our work, experience and encouraging results trombendarteriotomy which propose further efforts in the field of vascular surgery.
- Published
- 1978
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