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An "OFF/ON" electric current switching protocol was developed as a new strategy for one‐pot organic synthesis. Suzuki‐Miyaura coupling of 2‐bromopyridines with arylboronic acids in an electrochemical cell was performed without applying an electric current, and subsequently, the Pd‐catalyzed electrochemical C−H bromination was conducted using the already‐present Pd catalyst to obtain 2‐(2‐bromoaryl)pyridines as products. The one‐pot synthesis of bromoarenes can also be achieved without adding an external Br source in the second step. Furthermore, an OFF/ON/OFF two‐times switching protocol also realized the formation of an N‐containing teraryl derivative. [ABSTRACT FROM AUTHOR]

A general method is described for asymmetric synthesis of both syn- and anti-1,3-amino alcohols. This method is found to be effective for a variety of substrates incorporating either aromatic or various aliphatic substituents.

Deuterium-labeling experiments were performed for the Fe(PMe3)4-catalyzed C–H/olefin coupling using a deuterium-labeled aromatic ketone with various alkenes. While the reactions with a variety of alkenes provided the linear alkylation products formed via 1,2-insertion of alkene into an Fe–H bond, the reversible 2,1-insertion proceeded during the reaction highly depends on the choice of the alkene. No H/D scrambling resulting from 2,1-insertion/β-elimination was detected for the reactions with a vinylsilane and N -vinylcarbazole, but the reactions- with styrenes are considered to involve rapid 2,1-insertion/ β-elimination processes to cause significant levels of H/D scrambling. [ABSTRACT FROM AUTHOR]

Several mechanistic studies are conducted to explain the mechanisms involved in the reactions taking place between the aromatic ketones with olefins. The rate of C-H/olefin coupling is shown to exhibit a complete dependence on the concentration of the ruthenium complex in the system.

Theoretical and experimental studies are carried out for the three catalyst systems in order to answer a question that is unique for phosphine-sulfonate (P-S[O.sub.3]). The comparison of P-S[O.sub.3] and diphosphine (P-P) has shown that the [pi]-acrylonitrile complex is less stable than the corresponding [sigma]-complex in both the phosphine-sulfonato complex and the diphosphine complex and the comparison between P-S[O.sub.3] and imine-phenolate (N-O) has not shown any energetic difference in both AN insertion and its subsequent ethylene insertion.

Linear polyethylene propagation starting from Pd phosphine-sulfonate complexes is analyzed by using theoretical and experimental studied. The production of linear polyethylene with high molecular weight under ethylene pressure has shown that the cis and trans PdH(alkene)(phosphine-sulfonate) complexes are accessible in the pressure of excess amount of ethylene.

O-Acylanilines and a ruthenium complex are used for achieving the cleavage of unactivated aromatic C-N bonds on a late-transition-metal center. The results have shown that ruthenium-catalyzed C-C bond formation from o-acylaniline and organoboronate has proceeded via direct C-N bond cleavage on the ruthenium center.

Ruthenium-catalyzed regioselective direct amino- and alkoxycarbonylations of aromatic rings via C-H bond cleavage using chlorocarbonyl compounds are described. The generality of amide and ester groups is achieved by using carbonylating agents and alkyl chloroformates are also used for direct catalytic alkoxycarbonylation.

Several experiments are conducted to explain the mechanisms involved in the regiocontrolled copolymerization of a polar vinyl monomer with carbon monoxide (CO) by using methyl acrylate as a comonomer. The approach is shown to be extremely advantageous, as it helps in producing a copolymer with high level of head-to-tail regularity.

The first example of an alternating copolymerization of a polar vinyl monomer and carbon monoxide using vinyl acetate for the synthesis of [gamma]-polyketones is presented. The analysis provides a pathway for polymer synthesis with polar vinyl monomer, a cheap and easily available component.