136 results on '"Koch, Saskia B. J."'
Search Results
2. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
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Huggins, Ashley A., Baird, C. Lexi, Briggs, Melvin, Laskowitz, Sarah, Hussain, Ahmed, Fouda, Samar, Haswell, Courtney, Sun, Delin, Salminen, Lauren E., Jahanshad, Neda, Thomopoulos, Sophia I., Veltman, Dick J., Frijling, Jessie L., Olff, Miranda, van Zuiden, Mirjam, Koch, Saskia B. J., Nawjin, Laura, Wang, Li, Zhu, Ye, Li, Gen, Stein, Dan J., Ipser, Jonathan, Seedat, Soraya, du Plessis, Stefan, van den Heuvel, Leigh L., Suarez-Jimenez, Benjamin, Zhu, Xi, Kim, Yoojean, He, Xiaofu, Zilcha-Mano, Sigal, Lazarov, Amit, Neria, Yuval, Stevens, Jennifer S., Ressler, Kerry J., Jovanovic, Tanja, van Rooij, Sanne J. H., Fani, Negar, Hudson, Anna R., Mueller, Sven C., Sierk, Anika, Manthey, Antje, Walter, Henrik, Daniels, Judith K., Schmahl, Christian, Herzog, Julia I., Říha, Pavel, Rektor, Ivan, Lebois, Lauren A. M., Kaufman, Milissa L., Olson, Elizabeth A., Baker, Justin T., Rosso, Isabelle M., King, Anthony P., Liberzon, Isreal, Angstadt, Mike, Davenport, Nicholas D., Sponheim, Scott R., Disner, Seth G., Straube, Thomas, Hofmann, David, Qi, Rongfeng, Lu, Guang Ming, Baugh, Lee A., Forster, Gina L., Simons, Raluca M., Simons, Jeffrey S., Magnotta, Vincent A., Fercho, Kelene A., Maron-Katz, Adi, Etkin, Amit, Cotton, Andrew S., O’Leary, Erin N., Xie, Hong, Wang, Xin, Quidé, Yann, El-Hage, Wissam, Lissek, Shmuel, Berg, Hannah, Bruce, Steven, Cisler, Josh, Ross, Marisa, Herringa, Ryan J., Grupe, Daniel W., Nitschke, Jack B., Davidson, Richard J., Larson, Christine L., deRoon-Cassini, Terri A., Tomas, Carissa W., Fitzgerald, Jacklynn M., Blackford, Jennifer Urbano, Olatunji, Bunmi O., Kremen, William S., Lyons, Michael J., Franz, Carol E., Gordon, Evan M., May, Geoffrey, Nelson, Steven M., Abdallah, Chadi G., Levy, Ifat, Harpaz-Rotem, Ilan, Krystal, John H., Dennis, Emily L., Tate, David F., Cifu, David X., Walker, William C., Wilde, Elizabeth A., Harding, Ian H., Kerestes, Rebecca, Thompson, Paul M., and Morey, Rajendra
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- 2024
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3. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
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Yang, Jin, Huggins, Ashley A., Sun, Delin, Baird, C. Lexi, Haswell, Courtney C., Frijling, Jessie L., Olff, Miranda, van Zuiden, Mirjam, Koch, Saskia B. J., Nawijn, Laura, Veltman, Dick J., Suarez-Jimenez, Benjamin, Zhu, Xi, Neria, Yuval, Hudson, Anna R., Mueller, Sven C., Baker, Justin T., Lebois, Lauren A. M., Kaufman, Milissa L., Qi, Rongfeng, Lu, Guang Ming, Říha, Pavel, Rektor, Ivan, Dennis, Emily L., Ching, Christopher R. K., Thomopoulos, Sophia I., Salminen, Lauren E., Jahanshad, Neda, Thompson, Paul M., Stein, Dan J., Koopowitz, Sheri M., Ipser, Jonathan C., Seedat, Soraya, du Plessis, Stefan, van den Heuvel, Leigh L., Wang, Li, Zhu, Ye, Li, Gen, Sierk, Anika, Manthey, Antje, Walter, Henrik, Daniels, Judith K., Schmahl, Christian, Herzog, Julia I., Liberzon, Israel, King, Anthony, Angstadt, Mike, Davenport, Nicholas D., Sponheim, Scott R., Disner, Seth G., Straube, Thomas, Hofmann, David, Grupe, Daniel W., Nitschke, Jack B., Davidson, Richard J., Larson, Christine L., deRoon-Cassini, Terri A., Blackford, Jennifer U., Olatunji, Bunmi O., Gordon, Evan M., May, Geoffrey, Nelson, Steven M., Abdallah, Chadi G., Levy, Ifat, Harpaz-Rotem, Ilan, Krystal, John H., Morey, Rajendra A., and Sotiras, Aristeidis
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- 2024
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4. Acute-stress-induced change in salience network coupling prospectively predicts post-trauma symptom development
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Zhang, Wei, Kaldewaij, Reinoud, Hashemi, Mahur M., Koch, Saskia B. J., Smit, Annika, van Ast, Vanessa A., Beckmann, Christian F., Klumpers, Floris, and Roelofs, Karin
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- 2022
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5. Preserved spontaneous mentalizing amid reduced intersubject variability in autism during a movie narrative
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Mangnus, Margot, primary, Koch, Saskia B. J., additional, Cai, Kexin, additional, Greidanus Romaneli, Miriam, additional, Hagoort, Peter, additional, Bašnáková, Jana, additional, and Stolk, Arjen, additional
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- 2024
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6. Anterior prefrontal brain activity during emotion control predicts resilience to post-traumatic stress symptoms
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Kaldewaij, Reinoud, Koch, Saskia B. J., Hashemi, Mahur M., Zhang, Wei, Klumpers, Floris, and Roelofs, Karin
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- 2021
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7. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
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Wang, Xin, Xie, Hong, Chen, Tian, Cotton, Andrew S., Salminen, Lauren E., Logue, Mark W., Clarke-Rubright, Emily K., Wall, John, Dennis, Emily L., O’Leary, Brian M., Abdallah, Chadi G., Andrew, Elpiniki, Baugh, Lee A., Bomyea, Jessica, Bruce, Steven E., Bryant, Richard, Choi, Kyle, Daniels, Judith K., Davenport, Nicholas D., Davidson, Richard J., DeBellis, Michael, deRoon-Cassini, Terri, Disner, Seth G., Fani, Negar, Fercho, Kelene A., Fitzgerald, Jacklynn, Forster, Gina L., Frijling, Jessie L., Geuze, Elbert, Gomaa, Hassaan, Gordon, Evan M., Grupe, Dan, Harpaz-Rotem, Ilan, Haswell, Courtney C., Herzog, Julia I., Hofmann, David, Hollifield, Michael, Hosseini, Bobak, Hudson, Anna R., Ipser, Jonathan, Jahanshad, Neda, Jovanovic, Tanja, Kaufman, Milissa L., King, Anthony P., Koch, Saskia B. J., Koerte, Inga K., Korgaonkar, Mayuresh S., Krystal, John H., Larson, Christine, Lebois, Lauren A. M., Levy, Ifat, Li, Gen, Magnotta, Vincent A., Manthey, Antje, May, Geoffrey, McLaughlin, Katie A., Mueller, Sven C., Nawijn, Laura, Nelson, Steven M., Neria, Yuval, Nitschke, Jack B., Olff, Miranda, Olson, Elizabeth A., Peverill, Matthew, Luan Phan, K., Rashid, Faisal M., Ressler, Kerry, Rosso, Isabelle M., Sambrook, Kelly, Schmahl, Christian, Shenton, Martha E., Sierk, Anika, Simons, Jeffrey S., Simons, Raluca M., Sponheim, Scott R., Stein, Murray B., Stein, Dan J., Stevens, Jennifer S., Straube, Thomas, Suarez-Jimenez, Benjamin, Tamburrino, Marijo, Thomopoulos, Sophia I., van der Wee, Nic J. A., van der Werff, Steven J. A., van Erp, Theo G. M., van Rooij, Sanne J. H., van Zuiden, Mirjam, Varkevisser, Tim, Veltman, Dick J., Vermeiren, Robert R. J. M., Walter, Henrik, Wang, Li, Zhu, Ye, Zhu, Xi, Thompson, Paul M., Morey, Rajendra A., and Liberzon, Israel
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- 2021
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8. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
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Dennis, Emily L., Disner, Seth G., Fani, Negar, Salminen, Lauren E., Logue, Mark, Clarke, Emily K., Haswell, Courtney C., Averill, Christopher L., Baugh, Lee A., Bomyea, Jessica, Bruce, Steven E., Cha, Jiook, Choi, Kyle, Davenport, Nicholas D., Densmore, Maria, du Plessis, Stefan, Forster, Gina L., Frijling, Jessie L., Gonenc, Atilla, Gruber, Staci, Grupe, Daniel W., Guenette, Jeffrey P., Hayes, Jasmeet, Hofmann, David, Ipser, Jonathan, Jovanovic, Tanja, Kelly, Sinead, Kennis, Mitzy, Kinzel, Philipp, Koch, Saskia B. J., Koerte, Inga, Koopowitz, Sheri, Korgaonkar, Mayuresh, Krystal, John, Lebois, Lauren A. M., Li, Gen, Magnotta, Vincent A., Manthey, Antje, May, Geoff J., Menefee, Deleene S., Nawijn, Laura, Nelson, Steven M., Neufeld, Richard W. J., Nitschke, Jack B., O’Doherty, Daniel, Peverill, Matthew, Ressler, Kerry J., Roos, Annerine, Sheridan, Margaret A., Sierk, Anika, Simmons, Alan, Simons, Raluca M., Simons, Jeffrey S., Stevens, Jennifer, Suarez-Jimenez, Benjamin, Sullivan, Danielle R., Théberge, Jean, Tran, Jana K., van den Heuvel, Leigh, van der Werff, Steven J. A., van Rooij, Sanne J. H., van Zuiden, Mirjam, Velez, Carmen, Verfaellie, Mieke, Vermeiren, Robert R. J. M., Wade, Benjamin S. C., Wager, Tor, Walter, Henrik, Winternitz, Sherry, Wolff, Jonathan, York, Gerald, Zhu, Ye, Zhu, Xi, Abdallah, Chadi G., Bryant, Richard, Daniels, Judith K, Davidson, Richard J, Fercho, Kelene A, Franz, Carol, Geuze, Elbert, Gordon, Evan M, Kaufman, Milissa L, Kremen, William S., Lagopoulos, Jim, Lanius, Ruth A, Lyons, Michael J., McCauley, Stephen R, McGlinchey, Regina, McLaughlin, Katie A., Milberg, William, Neria, Yuval, Olff, Miranda, Seedat, Soraya, Shenton, Martha, Sponheim, Scott R., Stein, Dan J., Stein, Murray B., Straube, Thomas, Tate, David F., van der Wee, Nic J. A., Veltman, Dick J., Wang, Li., Wilde, Elisabeth A., Thompson, Paul M., Kochunov, Peter, Jahanshad, Neda, and Morey, Rajendra A.
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- 2021
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9. Larger dentate gyrus volume as predisposing resilience factor for the development of trauma-related symptoms
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Koch, Saskia B. J., van Ast, Vanessa A., Kaldewaij, Reinoud, Hashemi, Mahur M., Zhang, Wei, Klumpers, Floris, and Roelofs, Karin
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- 2021
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10. Emotion regulation flexibility: EEG/EMG predictors and consequences of switching between reappraisal and distraction strategies.
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Adamczyk, Agnieszka K., Koch, Saskia B. J., Wyczesany, Miroslaw, Roelofs, Karin, and van Peer, Jacobien M.
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EMOTION regulation , *MENTAL health , *DISTRACTION , *ELECTROMYOGRAPHY , *EXPECTATION (Psychology) - Abstract
Flexible use of emotion regulation (ER) strategies is central to mental health. To advance our understanding of what drives adaptive strategy‐switching decisions, in this preregistered study, we used event‐related potentials (late positive potential, LPP and stimulus preceding negativity, SPN) and facial electromyography (EMG corrugator activity) to test the antecedents and consequences of switching to an alternative ER strategy. Participants (N = 63, Mage = 24.8 years, all female) passively watched and then implemented an instructed ER strategy (reappraisal or distraction) in response to high‐intensity negative pictures that were either easy or difficult to reinterpret (high or low reappraisal affordance, respectively). Next, they decided to "switch from" or "maintain" the instructed strategy and subsequently implemented the chosen strategy. Reappraisal affordance manipulations successfully induced switching. Regarding antecedents, switching was predicted by the reduced ER efficacy of the current strategy (corrugator, but not LPP). Switching to distraction was additionally predicted by increased responses to the stimulus during passive viewing (corrugator and LPP) and increased anticipatory effort in implementing reappraisal (SPN). Concerning consequences, switching to distraction improved, whereas switching to reappraisal impaired post‐choice ER effects (LPP). However, starting with reappraisal was overall more effective than starting with distraction, irrespective of the subsequent decision (corrugator). Our results suggest that switching between ER strategies occurs in accordance with situational demands (stimulus affordances) and is predicted by reduced peripheral physiological ER efficacy. However, only switching to distraction leads to improved regulatory effects. These insights provide neurocognitively grounded starting points for developing interventions targeting ER flexibility. Flexible use of emotion regulation (ER) strategies is central to mental health. This study shows that flexible strategy‐switching decisions can be predicted based on psychophysiological responses that precede the decision to switch to an alternative ER strategy. Moreover, switching between the strategies results in distinctive regulatory effects, depending on the initial and chosen strategy. These insights into antecedents and consequences of strategy‐switching could inspire interventions targeting ER flexibility. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
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Yang, Jin, primary, Huggins, Ashley A., additional, Sun, Delin, additional, Baird, C. Lexi, additional, Haswell, Courtney C., additional, Frijling, Jessie L., additional, Olff, Miranda, additional, van Zuiden, Mirjam, additional, Koch, Saskia B. J., additional, Nawijn, Laura, additional, Veltman, Dick J., additional, Suarez-Jimenez, Benjamin, additional, Zhu, Xi, additional, Neria, Yuval, additional, Hudson, Anna R., additional, Mueller, Sven C., additional, Baker, Justin T., additional, Lebois, Lauren A. M., additional, Kaufman, Milissa L., additional, Qi, Rongfeng, additional, Lu, Guang Ming, additional, Říha, Pavel, additional, Rektor, Ivan, additional, Dennis, Emily L., additional, Ching, Christopher R. K., additional, Thomopoulos, Sophia I., additional, Salminen, Lauren E., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Stein, Dan J., additional, Koopowitz, Sheri M., additional, Ipser, Jonathan C., additional, Seedat, Soraya, additional, du Plessis, Stefan, additional, van den Heuvel, Leigh L., additional, Wang, Li, additional, Zhu, Ye, additional, Li, Gen, additional, Sierk, Anika, additional, Manthey, Antje, additional, Walter, Henrik, additional, Daniels, Judith K., additional, Schmahl, Christian, additional, Herzog, Julia I., additional, Liberzon, Israel, additional, King, Anthony, additional, Angstadt, Mike, additional, Davenport, Nicholas D., additional, Sponheim, Scott R., additional, Disner, Seth G., additional, Straube, Thomas, additional, Hofmann, David, additional, Grupe, Daniel W., additional, Nitschke, Jack B., additional, Davidson, Richard J., additional, Larson, Christine L., additional, deRoon-Cassini, Terri A., additional, Blackford, Jennifer U., additional, Olatunji, Bunmi O., additional, Gordon, Evan M., additional, May, Geoffrey, additional, Nelson, Steven M., additional, Abdallah, Chadi G., additional, Levy, Ifat, additional, Harpaz-Rotem, Ilan, additional, Krystal, John H., additional, Morey, Rajendra A., additional, and Sotiras, Aristeidis, additional
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- 2023
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12. How does it feel? An exploration of neurobiological and clinical correlates of alexithymia in trauma-exposed police-officers with and without PTSD
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van Sleeuwen, Cindy, primary, van Zuiden, Mirjam, additional, Koch, Saskia B. J., additional, Frijling, Jessie L., additional, Veltman, Dick J., additional, Olff, Miranda, additional, and Nawijn, Laura, additional
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- 2023
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13. On the Control of Social Approach–Avoidance Behavior: Neural and Endocrine Mechanisms
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Kaldewaij, Reinoud, Koch, Saskia B. J., Volman, Inge, Toni, Ivan, Roelofs, Karin, Geyer, Mark A., Series editor, Ellenbroek, Bart A., Series editor, Marsden, Charles A., Series editor, Barnes, Thomas R.E., Series editor, Wöhr, Markus, editor, and Krach, Sören, editor
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- 2017
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14. The role of the dentate gyrus in stress-related disorders
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Koch, Saskia B. J., Morey, Rajendra A., and Roelofs, Karin
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- 2020
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15. How does it feel?: An exploration of neurobiological and clinical correlates of alexithymia in trauma-exposed police-officers with and without PTSD
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Leerstoel Engelhard, Experimental psychopathology, van Sleeuwen, Cindy, van Zuiden, Mirjam, Koch, Saskia B J, Frijling, Jessie L, Veltman, Dick J, Olff, Miranda, Nawijn, Laura, Leerstoel Engelhard, Experimental psychopathology, van Sleeuwen, Cindy, van Zuiden, Mirjam, Koch, Saskia B J, Frijling, Jessie L, Veltman, Dick J, Olff, Miranda, and Nawijn, Laura
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- 2023
16. Neural Dynamics of Shooting Decisions and the Switch from Freeze to Fight
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Hashemi, Mahur M., Gladwin, Thomas E., de Valk, Naomi M., Zhang, Wei, Kaldewaij, Reinoud, van Ast, Vanessa, Koch, Saskia B. J., Klumpers, Floris, and Roelofs, Karin
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- 2019
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17. Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium
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Zhu, Xi, primary, Kim, Yoojean, additional, Ravid, Orren, additional, He, Xiaofu, additional, Suarez-Jimenez, Benjamin, additional, Zilcha-Mano, Sigal, additional, Lazarov, Amit, additional, Lee, Seonjoo, additional, Abdallah, Chadi G., additional, Angstadt, Michael, additional, Averill, Christopher L., additional, Baird, C. Lexi, additional, Baugh, Lee A., additional, Blackford, Jennifer U., additional, Bomyea, Jessica, additional, Bruce, Steven E., additional, Bryant, Richard A., additional, Cao, Zhihong, additional, Choi, Kyle, additional, Cisler, Josh, additional, Cotton, Andrew S., additional, Daniels, Judith K., additional, Davenport, Nicholas D., additional, Davidson, Richard J., additional, DeBellis, Michael D., additional, Dennis, Emily L., additional, Densmore, Maria, additional, deRoon-Cassini, Terri, additional, Disner, Seth G., additional, Hage, Wissam El, additional, Etkin, Amit, additional, Fani, Negar, additional, Fercho, Kelene A., additional, Fitzgerald, Jacklynn, additional, Forster, Gina L., additional, Frijling, Jessie L., additional, Geuze, Elbert, additional, Gonenc, Atilla, additional, Gordon, Evan M., additional, Gruber, Staci, additional, Grupe, Daniel W, additional, Guenette, Jeffrey P., additional, Haswell, Courtney C., additional, Herringa, Ryan J., additional, Herzog, Julia, additional, Hofmann, David Bernd, additional, Hosseini, Bobak, additional, Hudson, Anna R., additional, Huggins, Ashley A., additional, Ipser, Jonathan C., additional, Jahanshad, Neda, additional, Jia-Richards, Meilin, additional, Jovanovic, Tanja, additional, Kaufman, Milissa L., additional, Kennis, Mitzy, additional, King, Anthony, additional, Kinzel, Philipp, additional, Koch, Saskia B. J., additional, Koerte, Inga K., additional, Koopowitz, Sheri M., additional, Korgaonkar, Mayuresh S., additional, Krystal, John H., additional, Lanius, Ruth, additional, Larson, Christine L., additional, Lebois, Lauren A. M., additional, Li, Gen, additional, Liberzon, Israel, additional, Lu, Guang Ming, additional, Luo, Yifeng, additional, Magnotta, Vincent A., additional, Manthey, Antje, additional, Maron-Katz, Adi, additional, May, Geoffery, additional, McLaughlin, Katie, additional, Mueller, Sven C., additional, Nawijn, Laura, additional, Nelson, Steven M., additional, Neufeld, Richard W.J., additional, Nitschke, Jack B, additional, O’Leary, Erin M., additional, Olatunji, Bunmi O., additional, Olff, Miranda, additional, Peverill, Matthew, additional, Phan, K. Luan, additional, Qi, Rongfeng, additional, Quidé, Yann, additional, Rektor, Ivan, additional, Ressler, Kerry, additional, Riha, Pavel, additional, Ross, Marisa, additional, Rosso, Isabelle M., additional, Salminen, Lauren E., additional, Sambrook, Kelly, additional, Schmahl, Christian, additional, Shenton, Martha E., additional, Sheridan, Margaret, additional, Shih, Chiahao, additional, Sicorello, Maurizio, additional, Sierk, Anika, additional, Simmons, Alan N., additional, Simons, Raluca M., additional, Simons, Jeffrey S., additional, Sponheim, Scott R., additional, Stein, Murray B., additional, Stein, Dan J., additional, Stevens, Jennifer S., additional, Straube, Thomas, additional, Sun, Delin, additional, Théberge, Jean, additional, Thompson, Paul M., additional, Thomopoulos, Sophia I., additional, van der Wee, Nic J.A., additional, van der Werff, Steven J.A., additional, van Erp, Theo G. M., additional, van Rooij, Sanne J. H., additional, van Zuiden, Mirjam, additional, Varkevisser, Tim, additional, Veltman, Dick J., additional, Vermeiren, Robert R.J.M., additional, Walter, Henrik, additional, Wang, Li, additional, Wang, Xin, additional, Weis, Carissa, additional, Winternitz, Sherry, additional, Xie, Hong, additional, Zhu, Ye, additional, Wall, Melanie, additional, Neria, Yuval, additional, and Morey, Rajendra A., additional
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- 2022
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18. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results from the ENIGMA-PGC PTSD Consortium
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Sun, Delin, Rakesh, Gopalkumar, Clarke-Rubright, Emily K, Haswell, Courtney C, Logue, Mark, O'Leary, Erin N, Cotton, Andrew S, Xie, Hong, Dennis, Emily L, Jahanshad, Neda, Salminen, Lauren E, Thomopoulos, Sophia I, Rashid, Faisal, Ching, Christopher R K, Koch, Saskia B J, Frijling, Jessie L, Nawijn, Laura, van Zuiden, Mirjam, Zhu, Xi, Suarez-Jimenez, Benjamin, Sierk, Anika, Walter, Henrik, Manthey, Antje, Stevens, Jennifer S, Fani, Negar, van Rooij, Sanne J H, Stein, Murray, Bomyea, Jessica, Koerte, Inga, Choi, Kyle, van de Werff, Steven J A, Vermeiren, Robert R J M, Herzog, Julia, Lebois, Lauren A M, Baker, Justin T, Ressler, Kerry J, Olson, Elizabeth A, Straube, Thomas, Korgaonkar, Mayuresh S, Andrew, Elpiniki, Zhu, Ye, Li, Gen, Ipser, Jonathan, Hudson, Anna, Peverill, Matthew, Sambrook, Kelly, Gordon, Evan, Baugh, Lee, Forster, Gina, Simons, Raluca, Simons, Jeffrey, Magnotta, Vincent, Maron-Katz, Adi, du Plessis, Stefan, Disner, Seth, Davenport, Nicholas, Grupe, Dan, Nitschke, Jack, deRoon-Cassini, Terri A, Fitzgerald, Jacklynn, Krystal, John H, Levy, Ifat, Olff, Miranda, Veltman, Dick J, Wang, Li, Neria, Yuval, De Bellis, Michael D, Jovanovic, Tanja, Daniels, Judith K, Shenton, Martha, van de Wee, Nic J A, Schmahl, Christian, Kaufman, Milissa L, Rosso, Isabelle M, Sponheim, Scott R, Hofmann, David Bernd, Bryant, Richard A, Fercho, Kelene A, Stein, Dan J, Mueller, Sven C, Phan, Luan, McLaughlin, Katie A, Davidson, Richard J, Larson, Christine, May, Geoffrey, Nelson, Steven M, Abdallah, Chadi G, Gomaa, Hassaan, Etkin, Amit, Seedat, Soraya, Harpaz-Rotem, Ilan, Liberzon, Israel, Wang, Xin, Thompson, Paul M, Morey, Rajendra A, and Clinical Psychology and Experimental Psychopathology
- Abstract
BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA). METHODS: Neuroimaging and clinical data were aggregated from 29 research sites in >1,300 PTSD cases and >2,000 trauma-exposed controls (age 6.2-85.2 years) by the ENIGMA-PGC PTSD working group. Cortical regions in the network were rank-ordered by effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2 to 148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared to the mean SC of 5,000 randomly generated n-region networks. RESULTS: Patients with PTSD, relative to non-PTSD controls, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex and age modulated covariance differences of PTSD-related structural networks. CONCLUSIONS: Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The structural covariance networks that are perturbed in PTSD comport with converging evidence from resting state functional connectivity networks and networks impacted by inflammatory processes, and stress hormones in PTSD.
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- 2022
19. On the Control of Social Approach–Avoidance Behavior: Neural and Endocrine Mechanisms
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Kaldewaij, Reinoud, primary, Koch, Saskia B. J., additional, Volman, Inge, additional, Toni, Ivan, additional, and Roelofs, Karin, additional
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- 2016
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20. Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals
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Frijling, Jessie L, van Zuiden, Mirjam, Koch, Saskia B. J., Nawijn, Laura, Veltman, Dick J., and Olff, Miranda
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- 2016
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21. A Comparison of Methods to Harmonize Cortical Thickness Measurements Across Scanners and Sites
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Sun, Delin, primary, Rakesh, Gopalkumar, additional, Haswell, Courtney C., additional, Logue, Mark, additional, Lexi Baird, C., additional, O’Leary, Brian M., additional, Cotton, Andrew S., additional, Xie, Hong, additional, Tamburrino, Marijo, additional, Chen, Tian, additional, Dennis, Emily L., additional, Jahanshad, Neda, additional, Salminen, Lauren E., additional, Thomopoulos, Sophia I., additional, Rashid, Faisal, additional, Ching, Christopher R. K., additional, Koch, Saskia B. J., additional, Frijling, Jessie L., additional, Nawijn, Laura, additional, van Zuiden, Mirjam, additional, Zhu, Xi, additional, Suarez-Jimenez, Benjamin, additional, Sierk, Anika, additional, Walter, Henrik, additional, Manthey, Antje, additional, Stevens, Jennifer S., additional, Fani, Negar, additional, van Rooij, Sanne J.H., additional, Stein, Murray, additional, Bomyea, Jessica, additional, Koerte, Inga K., additional, Choi, Kyle, additional, van der Werff, Steven J.A., additional, Vermeiren, Robert R. J. M., additional, Herzog, Julia, additional, Lebois, Lauren A. M., additional, Baker, Justin T., additional, Olson, Elizabeth A., additional, Straube, Thomas, additional, Korgaonkar, Mayuresh S., additional, Andrew, Elpiniki, additional, Zhu, Ye, additional, Li, Gen, additional, Ipser, Jonathan, additional, Hudson, Anna R., additional, Peverill, Matthew, additional, Sambrook, Kelly, additional, Gordon, Evan, additional, Baugh, Lee, additional, Forster, Gina, additional, Simons, Raluca M., additional, Simons, Jeffrey S., additional, Magnotta, Vincent, additional, Maron-Katz, Adi, additional, du Plessis, Stefan, additional, Disner, Seth G., additional, Davenport, Nicholas, additional, Grupe, Daniel W., additional, Nitschke, Jack B., additional, deRoon-Cassini, Terri A., additional, Fitzgerald, Jacklynn M., additional, Krystal, John H., additional, Levy, Ifat, additional, Olff, Miranda, additional, Veltman, Dick J., additional, Wang, Li, additional, Neria, Yuval, additional, De Bellis, Michael D., additional, Jovanovic, Tanja, additional, Daniels, Judith K., additional, Shenton, Martha, additional, van de Wee, Nic J.A., additional, Schmahl, Christian, additional, Kaufman, Milissa L., additional, Rosso, Isabelle M., additional, Sponheim, Scott R., additional, Hofmann, David Bernd, additional, Bryant, Richard A., additional, Fercho, Kelene A., additional, Stein, Dan J., additional, Mueller, Sven C., additional, Hosseini, Bobak, additional, Luan Phan, K., additional, McLaughlin, Katie A., additional, Davidson, Richard J., additional, Larson, Christine L., additional, May, Geoffrey, additional, Nelson, Steven M., additional, Abdallah, Chadi G., additional, Gomaa, Hassaan, additional, Etkin, Amit, additional, Seedat, Soraya, additional, Harpaz-Rotem, Ilan, additional, Liberzon, Israel, additional, van Erp, Theo G.M., additional, Wang, Xin, additional, Thompson, Paul M., additional, and Morey, Rajendra A., additional
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- 2021
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22. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
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Wang, Xin, primary, Xie, Hong, additional, Chen, Tian, additional, Cotton, Andrew S., additional, Salminen, Lauren E., additional, Logue, Mark W., additional, Clarke-Rubright, Emily K., additional, Wall, John, additional, Dennis, Emily L., additional, O’Leary, Brian M., additional, Abdallah, Chadi G., additional, Andrew, Elpiniki, additional, Baugh, Lee A., additional, Bomyea, Jessica, additional, Bruce, Steven E., additional, Bryant, Richard, additional, Choi, Kyle, additional, Daniels, Judith K., additional, Davenport, Nicholas D., additional, Davidson, Richard J., additional, DeBellis, Michael, additional, deRoon-Cassini, Terri, additional, Disner, Seth G., additional, Fani, Negar, additional, Fercho, Kelene A., additional, Fitzgerald, Jacklynn, additional, Forster, Gina L., additional, Frijling, Jessie L., additional, Geuze, Elbert, additional, Gomaa, Hassaan, additional, Gordon, Evan M., additional, Grupe, Dan, additional, Harpaz-Rotem, Ilan, additional, Haswell, Courtney C., additional, Herzog, Julia I., additional, Hofmann, David, additional, Hollifield, Michael, additional, Hosseini, Bobak, additional, Hudson, Anna R., additional, Ipser, Jonathan, additional, Jahanshad, Neda, additional, Jovanovic, Tanja, additional, Kaufman, Milissa L., additional, King, Anthony P., additional, Koch, Saskia B. J., additional, Koerte, Inga K., additional, Korgaonkar, Mayuresh S., additional, Krystal, John H., additional, Larson, Christine, additional, Lebois, Lauren A. M., additional, Levy, Ifat, additional, Li, Gen, additional, Magnotta, Vincent A., additional, Manthey, Antje, additional, May, Geoffrey, additional, McLaughlin, Katie A., additional, Mueller, Sven C., additional, Nawijn, Laura, additional, Nelson, Steven M., additional, Neria, Yuval, additional, Nitschke, Jack B., additional, Olff, Miranda, additional, Olson, Elizabeth A., additional, Peverill, Matthew, additional, Phan, K. Luan, additional, Rashid, Faisal M., additional, Ressler, Kerry, additional, Rosso, Isabelle M., additional, Sambrook, Kelly, additional, Schmahl, Christian, additional, Shenton, Martha E., additional, Sierk, Anika, additional, Simons, Jeffrey S., additional, Simons, Raluca M., additional, Sponheim, Scott R., additional, Stein, Murray B., additional, Stein, Dan J., additional, Stevens, Jennifer S., additional, Straube, Thomas, additional, Suarez-Jimenez, Benjamin, additional, Tamburrino, Marijo, additional, Thomopoulos, Sophia I., additional, van der Wee, Nic J. A., additional, van der Werff, Steven J. A., additional, van Erp, Theo G. M., additional, van Rooij, Sanne J. H., additional, van Zuiden, Mirjam, additional, Varkevisser, Tim, additional, Veltman, Dick J., additional, Vermeiren, Robert R. J. M., additional, Walter, Henrik, additional, Wang, Li, additional, Zhu, Ye, additional, Zhu, Xi, additional, Thompson, Paul M., additional, Morey, Rajendra A., additional, and Liberzon, Israel, additional
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- 2020
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23. Early posttraumatic autonomic and endocrine markers to predict posttraumatic stress symptoms after a preventive intervention with oxytocin
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Engel, Sinha, primary, van Zuiden, Mirjam, additional, Frijling, Jessie. L., additional, Koch, Saskia B. J., additional, Nawijn, Laura, additional, Yildiz, Rinde L. W., additional, Schumacher, Sarah, additional, Knaevelsrud, Christine, additional, Bosch, Jos A., additional, Veltman, Dick J., additional, and Olff, Miranda, additional
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- 2020
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24. Neural Control of Emotional Actions in Response to Affective Vocalizations
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Koch, Saskia B. J., primary, Galli, Alessandra, additional, Volman, Inge, additional, Kaldewaij, Reinoud, additional, Toni, Ivan, additional, and Roelofs, Karin, additional
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- 2020
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25. Discriminating stress from rest based on resting‐state connectivity of the human brain: A supervised machine learning study
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Zhang, Wei, primary, Llera, Alberto, additional, Hashemi, Mahur M., additional, Kaldewaij, Reinoud, additional, Koch, Saskia B. J., additional, Beckmann, Christian F., additional, Klumpers, Floris, additional, and Roelofs, Karin, additional
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- 2020
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26. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
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Dennis, Emily L., primary, Disner, Seth G., additional, Fani, Negar, additional, Salminen, Lauren E., additional, Logue, Mark, additional, Clarke, Emily K., additional, Haswell, Courtney C., additional, Averill, Christopher L., additional, Baugh, Lee A., additional, Bomyea, Jessica, additional, Bruce, Steven E., additional, Cha, Jiook, additional, Choi, Kyle, additional, Davenport, Nicholas D., additional, Densmore, Maria, additional, du Plessis, Stefan, additional, Forster, Gina L., additional, Frijling, Jessie L., additional, Gonenc, Atilla, additional, Gruber, Staci, additional, Grupe, Daniel W., additional, Guenette, Jeffrey P., additional, Hayes, Jasmeet, additional, Hofmann, David, additional, Ipser, Jonathan, additional, Jovanovic, Tanja, additional, Kelly, Sinead, additional, Kennis, Mitzy, additional, Kinzel, Philipp, additional, Koch, Saskia B. J., additional, Koerte, Inga, additional, Koopowitz, Sheri, additional, Korgaonkar, Mayuresh, additional, Krystal, John, additional, Lebois, Lauren A. M., additional, Li, Gen, additional, Magnotta, Vincent A., additional, Manthey, Antje, additional, May, Geoff J., additional, Menefee, Deleene S., additional, Nawijn, Laura, additional, Nelson, Steven M., additional, Neufeld, Richard W. J., additional, Nitschke, Jack B., additional, O’Doherty, Daniel, additional, Peverill, Matthew, additional, Ressler, Kerry J., additional, Roos, Annerine, additional, Sheridan, Margaret A., additional, Sierk, Anika, additional, Simmons, Alan, additional, Simons, Raluca M., additional, Simons, Jeffrey S., additional, Stevens, Jennifer, additional, Suarez-Jimenez, Benjamin, additional, Sullivan, Danielle R., additional, Théberge, Jean, additional, Tran, Jana K., additional, van den Heuvel, Leigh, additional, van der Werff, Steven J. A., additional, van Rooij, Sanne J. H., additional, van Zuiden, Mirjam, additional, Velez, Carmen, additional, Verfaellie, Mieke, additional, Vermeiren, Robert R. J. M., additional, Wade, Benjamin S. C., additional, Wager, Tor, additional, Walter, Henrik, additional, Winternitz, Sherry, additional, Wolff, Jonathan, additional, York, Gerald, additional, Zhu, Ye, additional, Zhu, Xi, additional, Abdallah, Chadi G., additional, Bryant, Richard, additional, Daniels, Judith K, additional, Davidson, Richard J, additional, Fercho, Kelene A, additional, Franz, Carol, additional, Geuze, Elbert, additional, Gordon, Evan M, additional, Kaufman, Milissa L, additional, Kremen, William S., additional, Lagopoulos, Jim, additional, Lanius, Ruth A, additional, Lyons, Michael J., additional, McCauley, Stephen R, additional, McGlinchey, Regina, additional, McLaughlin, Katie A., additional, Milberg, William, additional, Neria, Yuval, additional, Olff, Miranda, additional, Seedat, Soraya, additional, Shenton, Martha, additional, Sponheim, Scott R., additional, Stein, Dan J., additional, Stein, Murray B., additional, Straube, Thomas, additional, Tate, David F., additional, van der Wee, Nic J. A., additional, Veltman, Dick J., additional, Wang, Li., additional, Wilde, Elisabeth A., additional, Thompson, Paul M., additional, Kochunov, Peter, additional, Jahanshad, Neda, additional, and Morey, Rajendra A., additional
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- 2019
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27. The role of the dentate gyrus in stress-related disorders
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Koch, Saskia B. J., primary, Morey, Rajendra A., additional, and Roelofs, Karin, additional
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- 2019
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28. High Endogenous Testosterone Levels Are Associated With Diminished Neural Emotional Control in Aggressive Police Recruits
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Kaldewaij, Reinoud, primary, Koch, Saskia B. J., additional, Zhang, Wei, additional, Hashemi, Mahur M., additional, Klumpers, Floris, additional, and Roelofs, Karin, additional
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- 2019
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29. ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW
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Koch, Saskia B. J., van Zuiden, Mirjam, Nawijn, Laura, Frijling, Jessie L., Veltman, Dick J., Olff, Miranda, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, and Anatomy and neurosciences
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BackgroundAbout 10% of trauma‐exposed individuals develop PTSD. Although a growing number of studies have investigated resting‐state abnormalities in PTSD, inconsistent results suggest a need for a meta‐analysis and a systematic review.MethodsWe conducted a systematic literature search in four online databases using keywords for PTSD, functional neuroimaging, and resting‐state. In total, 23 studies matched our eligibility criteria. For the meta‐analysis, we included 14 whole‐brain resting‐state studies, reporting data on 663 participants (298 PTSD patients and 365 controls). We used the activation likelihood estimation approach to identify concurrence of whole‐brain hypo‐ and hyperactivations in PTSD patients during rest. Seed‐based studies could not be included in the quantitative meta‐analysis. Therefore, a separate qualitative systematic review was conducted on nine seed‐based functional connectivity studies.ResultsThe meta‐analysis showed consistent hyperactivity in the ventral anterior cingulate cortex and the parahippocampus/amygdala, but hypoactivity in the (posterior) insula, cerebellar pyramis and middle frontal gyrus in PTSD patients, compared to healthy controls. Partly concordant with these findings, the systematic review on seed‐based functional connectivity studies showed enhanced salience network (SN) connectivity, but decreased default mode network (DMN) connectivity in PTSD.ConclusionsCombined, these altered resting‐state connectivity and activity patterns could represent neurobiological correlates of increased salience processing and hypervigilance (SN), at the cost of awareness of internal thoughts and autobiographical memory (DMN) in PTSD. However, several discrepancies between findings of the meta‐analysis and systematic review were observed, stressing the need for future studies on resting‐state abnormalities in PTSD patients.
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- 2016
30. Boosting oxytocin after trauma: Effects of oxytocin on fear neurocircuitry in patients with post-traumatic stress disorder
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Koch, Saskia B. J., Olff, Miranda, Veltman, D. J., van Zuiden, Mirjam, and Adult Psychiatry
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- 2016
31. The role of automatic defensive responses in the development of posttraumatic stress symptoms in police recruits: protocol of a prospective study
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Koch, Saskia B. J., primary, Klumpers, Floris, additional, Zhang, Wei, additional, Hashemi, Mahur M., additional, Kaldewaij, Reinoud, additional, van Ast, Vanessa A., additional, Smit, Annika S., additional, and Roelofs, Karin, additional
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- 2017
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32. The place of trauma in the treatment of personality disorders
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Olff, Miranda, Hendriks, Gert-Jan, De Kleine, Rianne, Van Minnen, Agnes, Ingenhoven, Theo J. M., Lindauer, Ramón J. L., Van Zuiden, Mirjam, Koch, Saskia B. J., Nawijn, Laura, Frijling, Jessie L., Veltman, Dick J., Van den Brink, Wim, van Marle, Hein, and Vermetten, Eric
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Editorial ,Supplement 1, 2015 - Published
- 2015
33. Social support, oxytocin, and PTSD
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Olff, Miranda, Tan, Zhonglin, Koch, Saskia B. J., Nawijn, Laura, Frijling, Jessie L., Van Zuiden, Mirjam, Veltman, Dick J., Kudler, Harold, Kim, Yoshiharu, O'Donnell, Meaghan, Wu, Kitty K., Kaysen, Debra, Stappenbeck, Cynthia, Rhew, Issac, Simpson, Tracy, Wang, Jian-Ping, Maercker, Andreas, Schnyder, Ulrich, Bao, Ai-Min, Swaab, Dick F., Jongedijk, Ruud A., Zhang, Yong-Hua, Zhang, Sujuan, Wang, Zhiyun, Reifels, Lennart, Bassilios, Bridget, Spittal, Matthew, King, Kylie, Fletcher, Justine, Pirkis, Jane, Teng, Pan, Hall, Brian J., Li, Ling, Chen, Wen, Wu, Yan, Zhou, Fangjing, Latkin, Carl, Cao, Chengqi, Wang, Li, Wang, Richu, Qing, Yulan, Zhang, Jianxin, Hong, Chunlan, Cao, Jingming, Efferth, Thomas, Xu, Kai, Chen, Liuxi, Fu, Lingyun, Mao, Hongjing, Liu, Jian, and Wang, Wei
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psychosocial support ,diagnosis ,alcohol abuse ,molecular mechanisms ,migration ,EMDR ,phenotypic model ,narratives ,spiritual pain ,grief ,genetics ,adherence ,family relationships ,intervention ,psychosocial recovery ,neuroimaging ,emotional disturbance ,fMRI ,loss ,PTSD ,amygdala ,flood ,refugees ,TCM ,Editorial ,trauma ,social resources ,transdiagnostic ,depression ,painful period ,psychological trauma ,self-efficacy ,primary mental healthcare ,China ,online interventions ,online self-help ,substance use ,CBT ,neurotransmitters ,neuromodulators ,oxytocin ,countertransference ,Chinese My Trauma Recovery ,resilience ,primary dysmenorrhea ,attachment ,screening ,HPA axis ,parental bonding ,evidence-based interventions ,early intervention ,Internet interventions ,orexin ,exposure ,earthquake ,Meeting Abstract ,cognitive therapy ,e-health ,tsunami ,BEPP ,psychosocial care ,efficacy ,psychotrauma ,disasters ,sexual trauma ,access to care ,treatment ,disaster relief ,drinking behavior ,transference ,anxiety ,evidence-based treatment ,comorbidity ,complex trauma ,emergency response ,culturally sensitive ,disaster ,biomarker ,RCT ,injury ,brain ,prevalence ,web-based ,association study ,agoraphobia ,sex steroids ,theory ,service use ,research ,bushfire ,victimization ,phytotherapy ,social support ,trauma-focused CBT ,Intimate partner violence ,NET ,mental health policy ,mini-interventions ,prolonged exposure ,CPT - Abstract
Background A lack of social support and recognition by the environment is one of the most consistent risk factors for posttraumatic stress disorder (PTSD), and PTSD patients will recover faster with proper social support. The oxytocin system has been proposed to underlie beneficial effects of social support as it is implicated in both social bonding behavior and reducing stress responsivity, notably amygdala reactivity (Koch et al., 2014; Olff et al., 2010; Olff, 2012). The amygdala is found to be hypersensitive in people with PTSD. Method In order to investigate neurobiological mechanisms underlying potential preventive and therapeutic effects of intranasal oxytocin, we performed a series of fMRI studies (funded with a prestigious NWO TOP grant): BONDS standing for “Boosting Oxytocin after trauma: Neurobiology and the Development of Stress-related psychopathology” in acutely traumatized persons admitted to the emergency department (Frijling et al., 2014); BOOSTER “Boosting oxytocin after trauma: the effects of intranasal oxytocin administration on emotional and motivational processing and neural activity in PTSD” in police officers with and without PTSD. Results In this presentation, we present the BOOSTER results on the effects of a single oxytocin administration on amygdala reactivity in response to emotional faces in PTSD patients versus traumatized controls. We found significantly decreased bilateral amygdala reactivity towards emotional faces in PTSD patients compared to traumatized controls. Conclusions These promising results call for intervention studies such as studying the effects of medication (oxytocin) enhanced psychotherapy in PTSD patients., Despite a large and rapidly expanding literature on psychological trauma, many fundamental questions remain about its basic nature: Is it a psychological problem or a biological one?; Is it a past event somehow stuck in the present or is it something new which has been triggered and shaped by that event?; Does it reside only within the patient or does it live between the patient and other people (including within the therapeutic relationship)? This presentation will review the history of the concept of psychological trauma and explore the theoretical bases for current evidence-based psychotherapies for PTSD, each of which will be shown to describe psychological trauma as a problem in bringing the past and the present together in memory and cognition. These theories primarily differ on the question of whether a traumatic memory becomes pathogenic, because it cannot be biologically processed or because it must be psychologically avoided. Psychoanalytic concepts of transference and countertransference will be shown to be of practical importance regardless of the type of treatment chosen. If researchers and clinicians can build on what they hold in common rather than become divided by their differences, we can improve our ability to understand and alleviate the effects of psychological trauma., On 11 March 2011, a devastating earthquake struck off the coast of Japan, causing blustering tsunami that swept over the northeast coast of the country. Many struggled to evacuate from their homes, schools, and workplaces as 8- to 9-m-tall tsunami rapidly reached the coast within half an hour after the earthquake (Emergency Disaster Response Headquarters). The officials reported a record-breaking magnitude of 9.0 Mw, which made this earthquake the most devastating earthquake in the Japan's history. It had not been long since the previous massive earthquake had hit Kobe in 1995, killing 6,434 people (Japan Meteorological Agency). The author presents the outline of the initial mental-health-care responses at various levels. It has focused on the comprehensive strategies and policies that were intended to cover all the affected areas but has not described the individual countermeasures and reactions in each prefecture and city. The psychological effects of the atomic plant accident in Fukushima has not been mentioned in detail, because the scope of the physiological effect of the accident has not been settled yet and the society is not necessarily ready to deal with the accident as a psychological matter rather than a sociopolitical one. A number of psychiatric professionals are deeply concerned with the psychological and prolonged impact of the accident, including those who are in the Fukushima prefecture and conducting heroic efforts to care for the residents., Background The 2010 iteration of the Global Burden of Disease statistics (Murray et al., 2012) points to the growing impact of injury and highlights the mounting burden of psychiatric disorder. It is essential to examine the intersection between these two contributors to disease burden. Methods The Australian Injury Vulnerability Study collected data of over 1,000 injury patients from their initial hospitalization to 6 years post-injury. Structured clinical interviews were used to diagnose psychiatric disorder and self-report measures for disability and symptom severity. Results A wide range of psychiatric disorders developed following injury, which included posttraumatic stress disorder, agoraphobia, depression, and substance use disorders (Bryant, O'Donnell, Creamer, Silove, & McFarlane, 2010). Although prevalence rates for these disorders were generally consistent over time, examination of trajectory data showed that different people had the disorders at different times. Importantly, the data showed that early anxiety, depression, and PTSD symptoms played a significant role in the development of long term disability after injury (Carty, O'Donnell, Evans, Kazantzis, & Creamer, 2011; O'Donnell et al., 2013). Conclusions These data support the view that transdiagnostic models for early intervention may be required to address the complex psychiatric disorder trajectories that develop after injury., Background The study examined the prevalence of trauma and posttraumatic stress disorder (PTSD) symptoms among community dwelling Chinese adults in Hong Kong. The relationship of traumatic life events (including loss) and mental health has been investigated. Methods The sampling of the collaborative study (HKMMS: Hong Kong Mental Morbidity Survey) adopts a multi-stage stratification approach with the distribution of residential premises in different geographical districts and the relative proportion of private versus public housing units taken into consideration. In Phase I of this study, 4,644 adults were screened for PTSD with the Trauma Screening Questionnaire (TSQ) and Life Event Checklist (LEC), Beck's scales and CIS-R (Revised Clinical Interview Schedule). In Phase II of the study, clinical psychologists conducted the Structured Clinical Interview for DSM Disorders (SCID) for 92 participants (results not reported here). Results Among Phase I participants, 65% reported traumatic experience (including 18% who reported personal experience of sudden death of significant others). Age and gender make a difference in traumatic experience. When compared to participants who reported no traumatic experience in the past, participants who reported to have personal experience of sudden death of significant others or other traumatic experiences were found to have higher TSQ scores, higher psychological distress, lower social support (PSS: Multidimensional Scale of Perceived Social Support), and lower life functioning (SOFAS: Social and Occupational Functioning Assessment Scale), p, Co-morbid PTSD and alcohol use disorders are both common and debilitating. However, many of these studies rely on cross-sectional studies that obscure more complex relationships between PTSD and drinking. Event-level studies allow for examination of proximal relationships between PTSD and drinking. Among women (n=136 with past sexual victimization, n=40 no past trauma history), a two-part mixed hurdle model was used to examine daily PTSD and drinking. On days women experienced more intrusive and behavioral avoidance symptoms, they were more likely to drink. For a 2 SD increase in symptoms, there was a 5% increased likelihood of drinking, and for a 2 SD increase in dysphoric symptoms or negative affect, women drank approximately half drink less. Daily-level coping self-efficacy moderated the association between distress and drinking (IRR=0.91, p, Background The Internet is now becoming a new channel for delivering psychological interventions. Method This paper reported a first application of web-based intervention in mainland China. It first summarized primary barriers to mental health help-seeking behavior in Chinese society. Then, it introduced the current utilization of the Internet within mental health services in mainland China and discussed how the Internet would help to improve people's help-seeking behaviors. More importantly, it presented main empirical findings from a randomized controlled trial (RCT) which investigated the efficacy of a web-based self-help intervention program (Chinese My Trauma Recovery website, CMTR) for 103 urban and 93 rural traumatized Chinese persons. Results The data revealed that 59% urban and 97% rural participants completed the posttest. In the urban sample, data showed a significant group×time interaction in Posttraumatic Diagnostic Scale (PDS) scores (F1,88=7.65, p=0.007). CMTR reduced posttraumatic symptoms significantly with high effect size after intervention (F1,45=15.13, Cohen's d=0.81, p, The efficacy of psychotherapeutic approaches in the treatment of posttraumatic stress disorder (PTSD) can be regarded as empirically demonstrated. Overall, effect sizes appear to be higher for psychotherapy than for medication. Many well-controlled trials with a mixed variety of trauma survivors have demonstrated that trauma-focused cognitive-behavioral therapy (TF-CBT) is effective in treating PTSD. Prolonged exposure therapy (PE) is currently seen as the treatment with the strongest evidence for its efficacy. Cognitive therapy (CT) and cognitive processing therapy (CPT), with their stronger emphasis on cognitive techniques, and Eye Movement Desensitization and Reprocessing (EMDR) seem equally effective. More recent developments include brief eclectic psychotherapy for PTSD (BEPP) and narrative exposure therapy (NET). Emerging evidence shows that TF-CBT can successfully be applied in PTSD patients suffering from severe comorbidities such as borderline personality disorder or substance abuse disorder (Schnyder & Cloitre, 2015). There is also a trend towards developing “mini-interventions,” that is, short modules tailored to approach specific problems. Moreover, evidence-based approaches should be complemented by interventions that aim at promoting human resilience to stress. Finally, given the globalization of our societies (Schnyder, 2013), culture-sensitive psychotherapists should try to understand the cultural components of a patient's illness and help-seeking behaviors, as well as their expectations with regard to treatment., After trauma, depressive disorders are among the most frequent emerging diagnoses. However, although the symptoms of depression are well characterized, the molecular mechanisms underlying this disorder are largely unknown. Factors involved in the heterogeneous pathogenesis of depression include polymorphisms in stress-related genes, gender, age, developmental history, and environmental (traumatic) stressors such as epigenetic factors. These factors may make different parts of the stress-related brain systems more vulnerable to different stressful or traumatic life events or psychological stresses, causing alterations in a network of neurotransmitters and neuromodulators including amines, amino acids, nitric oxide (NO), and neuropeptides, and finally make individuals at risk for depression. The hypothalamo–pituitary–adrenal (HPA) axis has a prominent position in this network. With the postmortem brain material obtained from the Netherlands Brain Bank, we have carried on a series of studies with the aim to elucidate the specific changes in these systems in relation to special subtypes of depression. Our final destination is to set up tailor-made treatment for depressive patients on the basis of his/her developmental history, genetic and epigenetic background, and the vulnerability in particular neurobiological systems. This presentation is a review of our findings of changes in systems of sex steroids, receptors in the hypothalamic paraventricular nucleus, corticotrophin-releasing hormone, orexin, γ-aminobutyric acid, and NO in the etiology of depression, in relation to HPA activity, sex differences, and suicide., Narrative exposure therapy (NET) is a recently developed, short-term treatment for patients with a posttraumatic stress disorder (PTSD) as a result of multiple trauma. NET can be applied very successfully in patients with complex trauma complaints (Jongedijk, 2014; Schauer, Neuner, & Elbert, 2011). An important feature of NET is that trauma processing is never an isolated event but is always embedded in the context of a traumatic event and in the life history as a whole. At the start, the lifeline is laid. The lifeline is made up of a rope, with flowers (happy events), stones (traumatic events), sometimes candles (grief), or recently also sticks for aggressive acts (NET for offenders; see Stenmark, Cuneyt Guzey, Elbert, & Holen, 2014). These symbols are laid down along the rope, in chronological order. Subsequently, in the subsequent therapy sessions the lifeline is processed in chronological order, giving attention to all the important events a person has experienced in his or her life, both the adverse as well as the pleasurable ones. The narration ends with a written testimony. To date, there is good evidence NET is effective in the treatment of PTSD patients, with support from 18 RCTs (N=950). For culturally diverse populations, NET is recommended as the most evidence-based trauma treatment, besides culturally adapted CBT. NET has been investigated in different populations in Africa, Europe, and Asia. In Asia, research has been carried out in Sri Lanka as well as in China. In China, NET was conducted and investigated with survivors of the Sichuan earthquake (Zang, Hunt, & Cox, 2013, 2014). NET is understandable, even appealing and also supportive for patients with multiple trauma. In this presentation, the treatment principles and the practice of NET will be explained., There is no disease called posttraumatic stress disorder (PTSD) in traditional Chinese medicine (TCM). However, Huangdi's Canon of Medicine written in about 200 BC, one of the most famous TCM classics, recorded diseases with similar etiology, pathogenesis, and clinical symptoms. Moreover, contemporary TCM also attaches great importance to diseases caused by trauma. Especially after 2008, there is a mini-rush of study on PTSD as a result of Sichuan earthquake. Referring to ancient and modern literature, we summarize the TCM treatment of PTSD and wish to contribute to the further study on TCM remedy for PTSD., Disaster is not independent of society and culture and always happens in specific cultural and social contexts. Cultural and social characteristics influence the responses of people affected by disaster, as well as the process of disaster relief. As one of the countries in the world that suffer most from natural disasters, various ethnic groups in China vary greatly in psychology and behavior characteristics after major disasters due to different geographical environments and economic and political conditions. To launch an effective post-disaster psychosocial care, 1) it is necessary to consider how to satisfy material, health, and other fundamental biological needs of affected people; 2) it is necessary to relieve disaster victims of their mental pain (spiritual in Chinese) and help them restore their psychological health; 3) it is necessary to revitalize the seriously unbalanced communities affected by disasters so that these communities would burst with vitality again. In addition, it is necessary to take specific ethnic and regional culture into account when helping people in these areas gradually achieve social adaptation and cultural identification. All these require us to intensify our efforts in the following four aspects: 1) to strengthen legislation and institutional construction in this field; 2) to help citizens master the most fundamental psychological principles and methods of coping with disasters to enable timely self-aid and mutual-aid; 3) to build a national database of the post-disaster psychosocial care teams; 4) to continue the research on disaster psychology, so as to provide a scientific basis as well as techniques and methods for implementing disaster relief efforts in a scientific way., Background This paper investigated adherence to a self-help web-based intervention for PTSD (Chinese My Trauma Recovery, CMTR) in mainland China and evaluated the association between adherence measures and potential predictors, for example, traumatic symptoms and self-efficacy. Methods Data from 56 urban and 90 rural trauma survivors were reported who used at least one of the seven recovery modules of CMTR. Results The results showed that 80% urban users visited CMTR four or less days and 87% rural users visited CMTR for 5 or 6 days. On average, urban users visited 2.54 (SD=1.99) modules on the first visiting day and less from the second day; rural users visited 1.10 (SD=0.54) modules on the first visiting day, and it became stable in the following days. In both samples, depression scores at pre-test were significantly or trend significantly associated with the number of visited web pages in the relaxation and professional help modules (r=0.20–0.26, all p, Background Mental health care services play an important role following disasters (Reifels et al., 2013). The aim of this study is to examine patterns and predictors of primary mental health care service use, following two major Australian natural disaster events. Method Utilizing referral and session data from a national minimum dataset, descriptive and regression analyses were conducted to identify levels and predictors of the use of the Access to Allied Psychological Services (ATAPS) program over a 2-year period following two major Australian bushfire and flood/cyclone disasters. Predictor variables examined in negative binomial regression analysis included consumer (age, gender, household structure, previous mental health care history, and diagnosis) and event characteristics (disaster type). Results The bushfire disaster resulted in significantly greater service volume, with more than twice the number of referrals and nearly three times the number of sessions. Service delivery for both disasters peaked in the third quarter. Consumers affected by bushfires, diagnosed with depression, anxiety, or both of these disorders utilized sessions at significantly higher rates. Conclusions The substantial demand for primary mental health services following disaster can vary with disaster type. Disaster type and need-based variables as key drivers of service use intensity indicate an equitable level of service use. Established usage patterns assist with estimating future service capacity requirements. Flexible referral pathways can enhance access to disaster mental health care. Future research should examine the impact of program- and agency-level factors on mental health service use and factors underpinning treatment non-adherence following disaster., Background Interpersonal violence (IPV) is associated with higher risk of depression. Female Chinese rural-to-urban migrants may experience greater depression following exposure to IPV due to lack of social support and integration within their receiving communities. The current study estimated the prevalence of IPV among rural-to-urban migrants in Guangzhou, China, and evaluated the moderating effects of social resources on migrant's depression symptoms. Method We recruited 1,368 women (1,003 migrants and 365 local-born) of childbearing age from population and family planning centers in two districts using a quota sampling method matched to the 2012 population census. Chinese versions of the Conflict Tactics Scale 2 Short Form, Center for Epidemiological Studies Depression Scale and the Social Support Rating Scale measured IPV, depression, and social support. Social integration was measured with a locally derived scale. Results Migrants reported a similar prevalence for IPV (41.20%) to local women (39.20%). Bivariate comparisons demonstrated that migrants reported greater depression (11.8±8.9 vs. 10.0±8.8, t=−3.27, p, Background Addressing the health needs of Chinese migrants is a critical public health concern. Epidemiological studies are needed to establish the prevalence of potentially traumatic events (PTEs) and common mental disorders among Chinese migrants and identify protective community and social resources. Method Utilizing random household sampling, we are in the process of recruiting a representative sample of Chinese adults (N=1,000) in two districts home to a large number of internal migrants. Data are collected using face-to-face interviews and participant self-report methods. Chinese versions of the Life Events Checklist, Alcohol Use Disorders Identification Test, Patient Health Questionnaire and the Social Support Rating Scale measured exposure to PTEs, alcohol use disorder, depression, and social support networks. Results Preliminary results indicate a high proportion (68%) of the sample was exposed directly or indirectly to at least one PTE. The most commonly reported events were transportation accidents (43%), natural disasters (39%), and physical assault (26%). A total of 17% of the sample reported drinking consistent with having an alcohol use disorder. Moderate or severe depression was reported by 9% of the sample. The majority (75%) reported having three or more people to rely on for support, and 41% reported active participation in civic groups. Despite these strengths, only half the sample reported having trust in their community. Conclusion Preliminary evidence from this population-level survey indicates high exposure to PTEs and a high potential burden of alcohol use disorders. The role of social networks will be explored as potentially useful for community-based intervention development., Background Posttraumatic stress disorder (PTSD) is a complex and severe mental disorder triggered by exposure to an extraordinarily traumatic event. Human and animal studies have implied the functional role of the oxytocin system in the development of PTSD (Cochran, Fallon, Hill, & Frazier, 2013; Koch et al., 2014; Olff, 2012). Specification of the role of the oxytocin system in the emergence and progression of PTSD symptomatology would provide evidence to inform both theory and clinical practice. Methods This study examined the association between oxytocin serum levels and PTSD symptoms. A total of 106 Chinese male adults who suffered from the deadly 2008 Wenchuan earthquake participated in this study. PTSD symptoms were measured with PTSD Checklist for DSM-5 (PCL-5), and serum oxytocin level was determined with ELISA oxytocin kits. Results The mean score on the PCL-5 was 19.30 (SD=14.50, range: 1–65) in this sample. The mean oxytocin level was 101.59 pg/ml (SD=55.89, range: 31.50–286.71). The results indicated that although the oxytocin was not associated with total PTSD symptoms, it was associated with PTSD's anxious arousal symptoms. Conclusion These findings support that the oxytocin may play an important functional role in the development of PTSD and contribute to the extant knowledge on the genetic basis of the PTSD symptoms., Background On May 12, 2008, an earthquake with a power of 8.0 M on the Richter scale occurred in the Wenchuan County of Sichuan Province in southwest China, which was unprecedented in magnitude and aftermath. Approximately 70,000 people were killed and nearly 20,000 went missing. The earthquake caused a wide number of mental and physical health outcomes among survivors, and posttraumatic stress disorder (PTSD) was one of the most commonly studied. Methods We conducted a systematic overview to assess research achievements about PTSD in the past 6 years after the Wenchuan earthquake, including symptoms and risk factors about PTSD among Wenchuan earthquake survivors, as well as research developments in genetics, molecular biology, and treatment of PTSD. Results The large body of research conducted after the Wenchuan earthquake suggests that the burden of PTSD among persons with high exposure was substantial. Adolescents and adults were among the most studied populations with high prevalence rates. Phytotherapy with Chinese herbs as well as acupuncture were rarely studied as of yet, although published data indicated promising therapy effects. Genome-wide microarray technologies are widely used in experimental mice and rat models to study PTSD mechanisms as well as in patients suffering from PTSD and other psychosomatic disorders to search for novel biomarkers and to monitor the effectiveness of treatment interventions. Conclusion Using genomic and transcriptomic technologies, our future research will focus on the efficacy and safety of Chinese medicine to find potential interventions and effective treatments of PTSD., Background Some evidence suggests that women with primary dysmenorrhea (or painful period) often have traumatic experience with parental attachments, but the exact relationship between styles of the parental bonding and the detailed aspects of the disorder is unclear. Methods From university-student women, we invited 50 primary dysmenorrhea patients and 111 healthy volunteers to undergo tests of the functional and emotional measure of dysmenorrhea (FEMD), the Family Relationship Questionnaire (FRQ), and the visual analog scale for the pain intensity experienced. Results Besides the high scores of the FEMD functional and emotional scales, the dysmenorrhea patients also scored significantly higher than the healthy controls on the FRQ scales of paternal dominance and maternal abuse. In patients, the FEMD Emotional scale was negatively predicted by the Paternal Freedom Release scale and the FEMD functional scale was positively predicted by the Maternal Dominance scale. Conclusion Inappropriate parental bonding or chronic traumatic attachment styles have respective relationships with the functional and emotional disturbances experienced by the primary dysmenorrhea patients.
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- 2014
34. Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
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Koch, Saskia B J, primary, van Zuiden, Mirjam, additional, Nawijn, Laura, additional, Frijling, Jessie L, additional, Veltman, Dick J, additional, and Olff, Miranda, additional
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- 2016
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35. Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals
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Frijling, Jessie L, primary, van Zuiden, Mirjam, additional, Koch, Saskia B. J., additional, Nawijn, Laura, additional, Veltman, Dick J., additional, and Olff, Miranda, additional
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- 2015
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36. Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals
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Frijling, Jessie L, primary, van Zuiden, Mirjam, additional, Koch, Saskia B J, additional, Nawijn, Laura, additional, Veltman, Dick J, additional, and Olff, Miranda, additional
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- 2015
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37. Intranasal oxytocin: miracle cure after trauma?
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Olff, Miranda, primary, Van Zuiden, Mirjam, additional, Koch, Saskia B. J., additional, Nawijn, Laura, additional, Frijling, Jessie L., additional, and Veltman, Dick J., additional
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- 2015
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38. Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial
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Frijling, Jessie L, van Zuiden, Mirjam, Koch, Saskia B J, Nawijn, Laura, Goslings, J Carel, Luitse, Jan S, Biesheuvel, Tessa H, Honig, Adriaan, Bakker, Fred C, Denys, D., Veltman, Dick J, Olff, Miranda, Frijling, Jessie L, van Zuiden, Mirjam, Koch, Saskia B J, Nawijn, Laura, Goslings, J Carel, Luitse, Jan S, Biesheuvel, Tessa H, Honig, Adriaan, Bakker, Fred C, Denys, D., Veltman, Dick J, and Olff, Miranda
- Abstract
BACKGROUND: Currently few evidence based interventions are available for the prevention of PTSD within the first weeks after trauma. Increased risk for PTSD development is associated with dysregulated fear and stress responses prior to and shortly after trauma, as well as with a lack of perceived social support early after trauma. Oxytocin is a potent regulator of these processes. Therefore, we propose that oxytocin may be important in reducing adverse consequences of trauma. The 'BONDS' study is conducted in order to assess the efficacy of an early intervention with intranasal oxytocin for the prevention of PTSD.METHODS/DESIGN: In this multicenter double-blind randomized placebo-controlled trial we will recruit 220 Emergency Department patients at increased risk of PTSD. Trauma-exposed patients are screened for increased PTSD risk with questionnaires assessing peri-traumatic distress and acute PTSD symptoms within 7 days after trauma. Baseline PTSD symptom severity scores and neuroendocrine and psychophysiological measures will be collected within 10 days after trauma. Participants will be randomized to 7.5 days of intranasal oxytocin (40 IU) or placebo twice a day. Follow-up measurements at 1.5, 3 and 6 months post-trauma are collected to assess PTSD symptom severity (the primary outcome measure). Other measures of symptoms of psychopathology, and neuroendocrine and psychophysiological disorders are secondary outcome measures.DISCUSSION: We hypothesize that intranasal oxytocin administered early after trauma is an effective pharmacological strategy to prevent PTSD in individuals at increased risk, which is both safe and easily applicable. Interindividual and contextual factors that may influence the effects of oxytocin treatment will be considered in the analysis of the results.TRIAL REGISTRATION: Netherlands Trial Registry: NTR3190.
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- 2014
39. Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study.
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Koch, Saskia B. J., van Zuiden, Mirjam, Nawijn, Laura, Frijling, Jessie L., Veltman, Dick J., and Olff, Miranda
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- *
AMYGDALOID body , *BIOLOGICAL models , *FRONTAL lobe , *MAGNETIC resonance imaging , *POLICE psychology , *POST-traumatic stress disorder , *PROBABILITY theory , *CONTROL groups , *NEURAL pathways - Abstract
Background: Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that has been associated with lower white matter integrity of tracts connecting the prefrontal cortex with limbic regions. However, previous diffusion tensor imaging (DTI) findings have been inconsistent, showing high variability in the exact location and direction of effects. Methods: We performed probabilistic tractography of the bilateral uncinate fasciculus, cingulum and superior longitudinal fasciculus (both temporal and parietal projections) in male and female police officers with and without PTSD. Results: We included 38 (21 men) police officers with and 39 (20 men) without PTSD in our analyses. Compared with trauma-exposed controls, patients with PTSD showed significantly higher mean diffusivity of the right uncinate fasciculus, the major white matter tract connecting the amygdala to the prefrontal cortex (p = 0.012). No other significant between- group or group x sex differences were observed. Mean diffusivity of the right uncinate fasciculus was positively associated with anxiety symptoms (r = 0.410, p = 0.013) in patients with PTSD as well as with amygdala activity (r = 0.247, p = 0.038) and ventromedial prefrontal cortex (vmPFC) activity (r = 0.283, p = 0.016) in all participants in response to happy and neutral faces. Limitations: Our specific sample of trauma-exposed police officers limits the generalizability of our findings to other PTSD patient groups (e.g., civilian trauma). Conclusion: Patients with PTSD showed diminished structural connectivity between the amygdala and vmPFC, which was correlated with higher anxiety symptoms and increased functional activity of these brain regions. Our findings provide additional evidence for the prevailing neurocircuitry model of PTSD, postulating that ineffective communication between the amygdala and vmPFC underlies decreased top--down control over fear responses. [ABSTRACT FROM AUTHOR]
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- 2017
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40. Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder.
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Nawijn, Laura, van Zuiden, Mirjam, Koch, Saskia B. J., Frijling, Jessie L., Veltman, Dick J., and Olff, Miranda
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TREATMENT of post-traumatic stress disorder ,OXYTOCIN ,REWARD (Psychology) ,SOCIAL support ,CLINICAL trials - Abstract
Therapeutic alliance and perceived social support are important predictors of treatment response for post-traumatic stress disorder (PTSD). Intranasal oxytocin administration may enhance treatment response by increasing sensitivity for social reward and thereby therapeutic alliance and perceived social support. As a first step to investigate this therapeutical potential, we investigated whether intranasal oxytocin enhances neural sensitivity to social reward in PTSD patients. Male and female police officers with (n = 35) and without PTSD (n = 37) were included in a double-blind, randomized, placebocontrolled cross-over fMRI study. After intranasal oxytocin (40 IU) and placebo administration, a social incentive delay task was conducted to investigate neural responses during social reward and punishment anticipation and feedback. Under placebo, PTSD patients showed reduced left anterior insula (AI) responses to social rewards (i.e. happy faces) compared with controls. Oxytocin administration increased left AI responses during social reward in PTSD patients, such that PTSD patients no longer differed from controls under placebo. Furthermore, in PTSD patients, oxytocin increased responses to social reward in the right putamen. By normalizing abberant insula responses and increasing putamen responses to social reward, oxytocin administration may enhance sensitivity for social support and therapeutic alliance in PTSD patients. Future studies are needed to investigate clinical effects of oxytocin. [ABSTRACT FROM AUTHOR]
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- 2017
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41. Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals
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Frijling, Jessie L, van Zuiden, Mirjam, Koch, Saskia B J, Nawijn, Laura, Veltman, Dick J, and Olff, Miranda
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Approximately 10% of trauma-exposed individuals go on to develop post-traumatic stress disorder (PTSD). Neural emotion regulation may be etiologically involved in PTSD development. Oxytocin administration early post-trauma may be a promising avenue for PTSD prevention, as intranasal oxytocin has previously been found to affect emotion regulation networks in healthy individuals and psychiatric patients. In a randomized double-blind placebo-controlled between-subjects functional magnetic resonance (fMRI) study, we assessed the effects of a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individuals within 11 days post trauma. Two resting-state scans were acquired; one after neutral- and one after trauma-script-driven imagery. We found that oxytocin administration reduced amygdala-left vlPFC FC after trauma script-driven imagery, compared with neutral script-driven imagery, whereas in PL-treated participants enhanced amygdala-left vlPFC FC was observed following trauma script-driven imagery. Irrespective of script condition, oxytocin increased amygdala–insula FC and decreased amygdala–vmPFC FC. These neural effects were accompanied by lower levels of sleepiness and higher flashback intensity in the oxytocin group after the trauma script. Together, our findings show that oxytocin administration may impede emotion regulation network functioning in response to trauma reminders in recently trauma-exposed individuals. Therefore, caution may be warranted in administering oxytocin to prevent PTSD in distressed, recently trauma-exposed individuals.
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- 2016
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42. Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial.
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Frijling, Jessie L., van Zuiden, Mirjam, Koch, Saskia B. J., Nawijn, Laura, Goslings, J. Carel, Luitse, Jan S., Biesheuvel, Tessa H., Honig, Adriaan, Bakker, Fred C., Denys, Damiaan, Veltman, Dick J., and Olff, Miranda
- Abstract
Background: Currently few evidence based interventions are available for the prevention of PTSD within the first weeks after trauma. Increased risk for PTSD development is associated with dysregulated fear and stress responses prior to and shortly after trauma, as well as with a lack of perceived social support early after trauma. Oxytocin is a potent regulator of these processes. Therefore, we propose that oxytocin may be important in reducing adverse consequences of trauma. The ‘BONDS’ study is conducted in order to assess the efficacy of an early intervention with intranasal oxytocin for the prevention of PTSD. Methods/Design: In this multicenter double-blind randomized placebo-controlled trial we will recruit 220 Emergency Department patients at increased risk of PTSD. Trauma-exposed patients are screened for increased PTSD risk with questionnaires assessing peri-traumatic distress and acute PTSD symptoms within 7 days after trauma. Baseline PTSD symptom severity scores and neuroendocrine and psychophysiological measures will be collected within 10 days after trauma. Participants will be randomized to 7.5 days of intranasal oxytocin (40 IU) or placebo twice a day. Follow-up measurements at 1.5, 3 and 6 months post-trauma are collected to assess PTSD symptom severity (the primary outcome measure). Other measures of symptoms of psychopathology, and neuroendocrine and psychophysiological disorders are secondary outcome measures. Discussion: We hypothesize that intranasal oxytocin administered early after trauma is an effective pharmacological strategy to prevent PTSD in individuals at increased risk, which is both safe and easily applicable. Interindividual and contextual factors that may influence the effects of oxytocin treatment will be considered in the analysis of the results. [ABSTRACT FROM AUTHOR]
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- 2014
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43. Pre-trauma sleep difficulties and fatigue predict trauma-induced changes in mental health symptoms in recruit police officers.
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Wolkow AP, Kaldewaij R, Klumpers F, Koch SBJ, Smit A, Drummond SPA, and Roelofs K
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- Humans, Adult, Male, Female, Middle Aged, Stress Disorders, Post-Traumatic psychology, Stress Disorders, Post-Traumatic epidemiology, Sleep Wake Disorders etiology, Police psychology, Fatigue etiology, Fatigue psychology
- Abstract
Competing Interests: Declaration of competing interest APW reports grants from the NHMRC (APP1138322), during the conduct of the study; grants from the Australian Research Council, outside the submitted work; and being a board member of the Sleep Health Foundation.
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- 2024
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44. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.
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Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah CG, Angstadt M, Averill CL, Baird CL, Baugh LA, Blackford JU, Bomyea J, Bruce SE, Bryant RA, Cao Z, Choi K, Cisler J, Cotton AS, Daniels JK, Davenport ND, Davidson RJ, DeBellis MD, Dennis EL, Densmore M, deRoon-Cassini T, Disner SG, Hage WE, Etkin A, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gonenc A, Gordon EM, Gruber S, Grupe DW, Guenette JP, Haswell CC, Herringa RJ, Herzog J, Hofmann DB, Hosseini B, Hudson AR, Huggins AA, Ipser JC, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman ML, Kennis M, King A, Kinzel P, Koch SBJ, Koerte IK, Koopowitz SM, Korgaonkar MS, Krystal JH, Lanius R, Larson CL, Lebois LAM, Li G, Liberzon I, Lu GM, Luo Y, Magnotta VA, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller SC, Nawijn L, Nelson SM, Neufeld RWJ, Nitschke JB, O'Leary EM, Olatunji BO, Olff M, Peverill M, Phan KL, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso IM, Salminen LE, Sambrook K, Schmahl C, Shenton ME, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons AN, Simons RM, Simons JS, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Sun D, Théberge J, Thompson PM, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, and Morey RA
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- Humans, Reproducibility of Results, Big Data, Neuroimaging, Magnetic Resonance Imaging methods, Brain diagnostic imaging, Stress Disorders, Post-Traumatic diagnostic imaging
- Abstract
Background: Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group., Methods: We analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls using traditional machine learning methods. Second, we assessed the utility of the denoising variational autoencoder (DVAE) and evaluated its classification performance. Third, we assessed the generalizability and reproducibility of both models using leave-one-site-out cross-validation procedure for each modality., Results: We found lower performance in classifying PTSD vs. controls with data from over 20 sites (60 % test AUC for s-MRI, 59 % for rs-fMRI and 56 % for d-MRI), as compared to other studies run on single-site data. The performance increased when classifying PTSD from HC without trauma history in each modality (75 % AUC). The classification performance remained intact when applying the DVAE framework, which reduced the number of features. Finally, we found that the DVAE framework achieved better generalization to unseen datasets compared with the traditional machine learning frameworks, albeit performance was slightly above chance., Conclusion: These results have the potential to provide a baseline classification performance for PTSD when using large scale neuroimaging datasets. Our findings show that the control group used can heavily affect classification performance. The DVAE framework provided better generalizability for the multi-site data. This may be more significant in clinical practice since the neuroimaging-based diagnostic DVAE classification models are much less site-specific, rendering them more generalizable., Competing Interests: Declaration of Competing Interest Dr. Thompson received partial grant support from Biogen, Inc., and Amazon, Inc., for work unrelated to the current study; Dr. Lebois reports unpaid membership on the Scientific Committee for International Society for the Study of Trauma and Dissociation (ISSTD), grant support from the National Institute of Mental Health, K01 MH118467 and the Julia Kasparian Fund for Neuroscience Research, McLean Hospital. Dr. Lebois also reports spousal IP payments from Vanderbilt University for technology licensed to Acadia Pharmaceuticals unrelated to the present work. ISSTD and NIMH were not involved in the analysis or preparation of the manuscript; Dr. Etkin reports salary and equity from Alto Neuroscience, equity from Mindstrong Health and Akili Interactive. Other authors have no conflicts of interest to declare., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2023
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45. Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium.
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Suarez-Jimenez B, Lazarov A, Zhu X, Zilcha-Mano S, Kim Y, Marino CE, Rjabtsenkov P, Bavdekar SY, Pine DS, Bar-Haim Y, Larson CL, Huggins AA, Terri deRoon-Cassini, Tomas C, Fitzgerald J, Kennis M, Varkevisser T, Geuze E, Quidé Y, El Hage W, Wang X, O'Leary EN, Cotton AS, Xie H, Shih C, Disner SG, Davenport ND, Sponheim SR, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Olff M, Veltman DJ, Gordon EM, May G, Nelson SM, Jia-Richards M, Neria Y, and Morey RA
- Abstract
Background: Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and involuntary re-experiencing of the trauma, namely, intrusive memories, nightmares, and flashbacks. The aim of the present study was to explore ITRED from a neural network connectivity perspective., Methods: Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium ( n = 584) and included itemized PTSD symptom scores and resting-state functional connectivity (rsFC) data. We assessed the utility of rsFC in classifying PTSD, ITRED-only (no PTSD diagnosis), and trauma-exposed (TE)-only (no PTSD or ITRED) groups using a machine learning approach, examining well-known networks implicated in PTSD. A random forest classification model was built on a training set using cross-validation, and the averaged cross-validation model performance for classification was evaluated using the area under the curve. The model was tested using a fully independent portion of the data (test dataset), and the test area under the curve was evaluated., Results: rsFC signatures differentiated TE-only participants from PTSD and ITRED-only participants at about 60% accuracy. Conversely, rsFC signatures did not differentiate PTSD from ITRED-only individuals (45% accuracy). Common features differentiating TE-only participants from PTSD and ITRED-only participants mainly involved default mode network-related pathways. Some unique features, such as connectivity within the frontoparietal network, differentiated TE-only participants from one group (PTSD or ITRED-only) but to a lesser extent from the other group., Conclusions: Neural network connectivity supports ITRED as a novel neurobiologically based approach to classifying posttrauma psychopathology., (© 2023 The Authors.)
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- 2023
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46. Trauma-induced human glucocorticoid receptor expression increases predict subsequent HPA-axis blunting in a prospective longitudinal design.
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de Voogd LD, Kampen RA, Kaldewaij R, Zhang W, Hashemi MM, Koch SBJ, Klumpers F, Glennon JC, and Roelofs K
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One of the hallmarks of post-traumatic stress disorder (PTSD) is abnormalities in the HPA-axis. This includes alterations in its negative feedback regulation. Although altered glucocorticoid receptor (GR) mRNA expression is thought to play a crucial role herein, direct longitudinal evidence in humans is lacking to support this assumption. The current prospective longitudinal study assessed the consequence of repeated trauma exposure on GR mRNA expression from saliva samples in early-career police recruits (n = 112) by assessing them before and after trauma exposure. We did not observe a relationship between change in GR mRNA expression and development of PTSD symptom severity. However, the more traumatic events were experienced during police training the stronger GR mRNA expression was increased. Moreover, increases in GR mRNA expression were associated with blunted HPA-axis stress-reactivity at follow-up compared to baseline. This study provides the first longitudinal evidence of a dose-response relationship between trauma and human GR mRNA expression (extracted from saliva) changes; therefore, replication is warranted. Our finding might contribute a possible explanatory framework for blunted HPA-axis function associated with PTSD., Competing Interests: Competing interest All authors declared no competing interests., (Copyright © 2022. Published by Elsevier Ltd.)
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- 2022
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47. A comparison of methods to harmonize cortical thickness measurements across scanners and sites.
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Sun D, Rakesh G, Haswell CC, Logue M, Baird CL, O'Leary EN, Cotton AS, Xie H, Tamburrino M, Chen T, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte IK, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons RM, Simons JS, Magnotta V, Maron-Katz A, du Plessis S, Disner SG, Davenport N, Grupe DW, Nitschke JB, deRoon-Cassini TA, Fitzgerald JM, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Hosseini B, Phan KL, McLaughlin KA, Davidson RJ, Larson CL, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, van Erp TGM, Quidé Y, Wang X, Thompson PM, and Morey RA
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- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Female, Humans, Male, Middle Aged, Neuroimaging, Young Adult, Magnetic Resonance Imaging methods, Stress Disorders, Post-Traumatic
- Abstract
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LME
INT ), (2) LME that models both site-specific random intercepts and age-related random slopes (LMEINT+SLP ), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 cases with posttraumatic stress disorder (PTSD) (6.2-81.8 years old) and 2,057 trauma-exposed controls without PTSD (6.3-85.2 years old). We found that, compared to the other data harmonization methods, data processed with ComBat-GAM was more sensitive to the detection of significant case-control differences (Χ2 (3) = 63.704, p < 0.001) as well as case-control differences in age-related cortical thinning (Χ2 (3) = 12.082, p = 0.007). Both ComBat and ComBat-GAM outperformed LME methods in detecting sex differences (Χ2 (3) = 9.114, p = 0.028) in regional cortical thickness. ComBat-GAM also led to stronger estimates of age-related declines in cortical thickness (corrected p-values < 0.001), stronger estimates of case-related cortical thickness reduction (corrected p-values < 0.001), weaker estimates of age-related declines in cortical thickness in cases than controls (corrected p-values < 0.001), stronger estimates of cortical thickness reduction in females than males (corrected p-values < 0.001), and stronger estimates of cortical thickness reduction in females relative to males in cases than controls (corrected p-values < 0.001). Our results support the use of ComBat-GAM to minimize confounds and increase statistical power when harmonizing data with non-linear effects, and the use of either ComBat or ComBat-GAM for harmonizing data with linear effects., Competing Interests: Conflicts of Interest Dr. Abdallah has served as a consultant, speaker and/or on advisory boards for FSV7, Lundbeck, Psilocybin Labs, Genentech and Janssen, and editor of Chronic Stress for Sage Publications, Inc.; he has filed a patent for using mTOR inhibitors to augment the effects of antidepressants (filed on August 20, 2018). Dr. Davidson is the founder and president of, and serves on the board of directors for, the non-profit organization Healthy Minds Innovations, Inc. Dr. Jahanshad, Dr. Thompson and Dr. Ching received partial research support from Biogen, Inc. (Boston, USA) for research unrelated to the content of this manuscript. Dr. Krystal is a consultant for AbbVie, Inc., Amgen, Astellas Pharma Global Development, Inc., AstraZeneca Pharmaceuticals, Biomedisyn Corporation, Bristol-Myers Squibb, Eli Lilly and Company, Euthymics Bioscience, Inc., Neurovance, Inc., FORUM Pharmaceuticals, Janssen Research & Development, Lundbeck Research USA, Novartis Pharma AG, Otsuka America Pharmaceutical, Inc., Sage Therapeutics, Inc., Sunovion Pharmaceuticals, Inc., and Takeda Industries; is on the Scientific Advisory Board for Lohocla Research Corporation, Mnemosyne Pharmaceuticals, Inc., Naurex, Inc., and Pfizer; is a stockholder in Biohaven Pharmaceuticals; holds stock options in Mnemosyne Pharmaceuticals, Inc.; holds patents for Dopamine and Noradrenergic Reuptake Inhibitors in Treatment of Schizophrenia, US Patent No. 5,447,948 (issued September 5, 1995), and Glutamate Modulating Agents in the Treatment of Mental Disorders, U.S. Patent No. 8,778,979 (issued July 15, 2014); and filed a patent for Intranasal Administration of Ketamine to Treat Depression. U.S. Application No. 14/197,767 (filed on March 5, 2014); US application or Patent Cooperation Treaty international application No. 14/306,382 (filed on June 17, 2014); Filed a patent for using mTOR inhibitors to augment the effects of antidepressants (filed on August 20, 2018). Dr. Schmahl is a consultant for Boehringer Ingelheim International GmbH. Dr. Stein has received research grants and/or consultancy honoraria from Lundbeck and Sun. Dr. Lebois reports unpaid membership on the Scientific Committee for the International Society for the Study of Trauma and Dissociation (ISSTD) and spousal license payment for Vanderbilt IP from Acadia Pharmaceuticals unrelated to the topic of this manuscript. All other authors have no conflicts of interest to declare., (Copyright © 2022. Published by Elsevier Inc.)- Published
- 2022
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48. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.
- Author
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Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, and Morey RA
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Humans, Magnetic Resonance Imaging methods, Middle Aged, Neuroimaging, Young Adult, Connectome methods, Stress Disorders, Post-Traumatic
- Abstract
Background: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA)., Methods: Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2-148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks., Results: Patients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks., Conclusions: Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD., (Copyright © 2022 Society of Biological Psychiatry. All rights reserved.)
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- 2022
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49. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.
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Clausen AN, Fercho KA, Monsour M, Disner S, Salminen L, Haswell CC, Rubright EC, Watts AA, Buckley MN, Maron-Katz A, Sierk A, Manthey A, Suarez-Jimenez B, Olatunji BO, Averill CL, Hofmann D, Veltman DJ, Olson EA, Li G, Forster GL, Walter H, Fitzgerald J, Théberge J, Simons JS, Bomyea JA, Frijling JL, Krystal JH, Baker JT, Phan KL, Ressler K, Han LKM, Nawijn L, Lebois LAM, Schmaal L, Densmore M, Shenton ME, van Zuiden M, Stein M, Fani N, Simons RM, Neufeld RWJ, Lanius R, van Rooij S, Koch SBJ, Bonomo S, Jovanovic T, deRoon-Cassini T, Ely TD, Magnotta VA, He X, Abdallah CG, Etkin A, Schmahl C, Larson C, Rosso IM, Blackford JU, Stevens JS, Daniels JK, Herzog J, Kaufman ML, Olff M, Davidson RJ, Sponheim SR, Mueller SC, Straube T, Zhu X, Neria Y, Baugh LA, Cole JH, Thompson PM, and Morey RA
- Subjects
- Adolescent, Adult, Aged, Aging, Brain diagnostic imaging, Brain pathology, Female, Humans, Machine Learning, Magnetic Resonance Imaging methods, Male, Middle Aged, Young Adult, Stress Disorders, Post-Traumatic diagnostic imaging
- Abstract
Background: Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD., Method: Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA-PGC PTSD sites underwent T1-weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel-wise (brainageR) and region-of-interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age - chronological age) controlling for chronological age, sex, and scan site., Results: BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three-way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages., Discussion: Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age-related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan., (© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
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- 2022
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50. Human defensive freezing: Associations with hair cortisol and trait anxiety.
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Hashemi MM, Zhang W, Kaldewaij R, Koch SBJ, Smit A, Figner B, Jonker R, Klumpers F, and Roelofs K
- Subjects
- Adult, Female, Humans, Hypothalamo-Hypophyseal System physiology, Male, Pituitary-Adrenal System physiology, Young Adult, Anxiety physiopathology, Fear physiology, Fear psychology, Hair chemistry, Hydrocortisone metabolism
- Abstract
The anticipation of threat facilitates innate defensive behaviours including freezing reactions. Freezing in humans is characterised by reductions in body sway and heart rate. Limited evidence suggests that individual differences in freezing reactions are associated with predictors of anxiety-related psychopathology including trait anxiety and hypothalamic-pituitary-adrenal (HPA) axis activity. However, previous human studies focused on acutely circulating cortisol levels, leaving the link between freezing and more stable, individual trait markers of HPA axis activity unclear. We investigated whether individual differences in anticipatory freezing reactions are predicted by accumulated hair cortisol concentrations (HCC) and trait anxiety, in a well-powered mixed sample of police recruits at the start of the police training, and age, sex and education matched controls (total N = 419, mean age = 24, N
women = 106, Npolice recruits = 337). Freezing-related reactions were assessed with posturographic and heart rate measurements during an active shooting task under threat of shock. The anticipation of threat of shock elicited the expected reductions in body sway and heart rate, indicative of human freezing. Individual differences in threat-related reductions in body sway, but not heart rate, were related to lower HCC and higher trait anxiety. The observed links between postural freezing and predictors of anxiety-related psychopathology suggest the potential value of defensive freezing as a somatic marker for individual differences in stress-vulnerability and resilience. DATA AVAILABILITY: The datasets analysed during the current study are available from the corresponding authors upon reasonable request., (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2021
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