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185 results on '"Koch, Karl M."'

3. Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

Author

Kurts, Christian, Carbone, Francis R., Krummel, Matthew F., Koch, Karl M., Miller, Jacques F.A.P., and Heath, William R.

Subjects
Autoimmunity -- Research, T cells -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A new mechanism protects against autoimmunity and involves CD30. CD30-deficient islet-specific CD8-positive T cells are about 6,000 times more autoaggresive than wild-type cells. In the absence of CD30 signalling, cells activated by the CD95 dependent cross-tolerance mechanism, are able to proliferate on secondary encounter with antigen on pancreatic islets. CD30 signalling thus restricts the proliferative potential of CD8 effector T cells.

Published
1999

5. Urodilatin is involved in sodium homeostasis and exerts sodium-state-dependent natriuretic and diuretic effects

Author

Meyer, Markus, Richter, Rudolf, Brunkhorst, Reinhard, Wrenger, Eike, Schulz-Knappe, Peter, Kist, Andreas, Mentz, Peter, Brabant, Ernst G., Koch, Karl M., Rechkemmer, Gerhard, and Forssmann, Wolf-Georg

Subjects
Sodium metabolism -- Physiological aspects, Natriuresis -- Regulation, Diuresis -- Physiological aspects, Peptide hormones -- Physiological aspects, Biological sciences
Abstract

Urodilatin is a member of the natriuretic peptide family synthesized by the kidney to regulate renal function. In a study of eight healthy, male subjects, ingestion of 52, 172.6 and 347.8 mmol sodium/day for seven days resulted in increased urodilatin and sodium excretion at the end of the diet. Infusion of urodilatin at the end of each diet caused a marked increase in natriuresis and diuresis. These results suggest that urodilatin contributes to the regulation of sodium fluid balance and that renal function in response to urodilatin is modulated by sodium balance.

Published
1996

47. Replacement of Renal Function by Dialysis.

Author

Jacobs, C., Kjellstrand, C. M., Koch, K. M., Winchester, J. F., Lonnemann, Gerhard, and Koch, Karl M.

Abstract

In this review we will discuss the importance of bacterial contamination of dialysate fluid and the associated risk of pyrogenic reactions for patients on hemodialysis therapy. The degree of bacterial contamination of dialysate, relevant bacterial species and pyrogenic substances released from these microorganisms will be described. In addition, information about bacteriological methods to determine bacterial growth as well as assays to measure the pyrogenic activity of bacteria-derived substances will be given. Furthermore, we will describe in vitro studies testing the permeability of dialyzer membranes to pyrogenic substances derived from dialysate-born bacteria. We will discuss recent investigations suggesting that bacterial contamination of dialysate may cause repeated stimulation of immuno-competent cells including monocytes, lymphocytes and neutrophils, resulting in increased production of inflammatory mediators in end-stage renal disease (ESRD) patients. Finally, we will describe an effective approach to reduce the bacterial contamination of dialysis and the associated risk of pyrogenic reactions during hemodialysis [ABSTRACT FROM AUTHOR]

Published
1996
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