76 results on '"Kocaturk E"'
Search Results
2. A comparative analysis of chronic inducible urticaria in 423 patients: Clinical and laboratory features and comorbid conditions.
- Author
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Ornek Ozdemir, S., Kuteyla Can, P., Degirmentepe, E. N., Cure, K., Singer, R., and Kocaturk, E.
- Subjects
URTICARIA ,PATHOLOGICAL laboratories ,COMORBIDITY ,COMPARATIVE studies ,ANGIONEUROTIC edema ,IMMUNOGLOBULIN E - Abstract
Background: Chronic inducible urticaria (CIndU) is a subtype of chronic urticaria (CU) which require specific physical or non‐physical triggers to occur. They may be isolated or may coexist with chronic spontaneous urticaria (CSU). Despite their frequent appearance in dermatology clinics, there is scarce information on the distinguishing features among the most common subtypes of CIndU as well as isolated CIndU versus CSU plus CIndU. Objectives: To compare clinical and laboratory characteristics, and comorbid conditions among the most common CIndU types and isolated CIndU versus CSU plus CIndU. Methods: We retrospectively analysed CIndU patients and compared patients' demographic, clinical and laboratory characteristics across isolated CIndU, CSU plus CIndU, symptomatic dermographism (SD), cold urticaria (ColdU) and cholinergic urticaria (ChoU). Results: A total of 423 patients (~70% isolated CIndU, ~30% CSU plus CIndU, ~5% mixed CIndU subtypes) were included in the study. The most frequent CIndU subtypes were SD (68.6%; 290/423), ColdU (11.4%; 48/423) and ChoU (10.9%; 46/423). Isolated CIndU patients were younger than CSU plus CIndU (33.74 ± 12.72 vs. 37.06 ± 11.84, p = 0.010). Angioedema, emergency referrals, need for systemic steroids, comorbid systemic disorders were more frequent and baseline urticaria control test scores were lower in CSU plus CIndU patients (vs. CIndU, p < 0.001, p = 0.008, p < 0.001, p = 0.031, p = 0.036, respectively). Among CIndU subtypes, ChoU patients were younger (24.9 ± 12.2 vs. 34.47 ± 12.12 vs. 31.38 ± 14.95; p < 0.001) and had male predominance (p < 0.001) while SD patients had no angioedema (p < 0.001) and had higher frequency of increased total IgE levels (p = 0.006). Conclusions: Isolated CIndU and CSU plus CIndU seems to be different endotypes of CU where CSU plus CIndU presents a more severe and refractory course. There are distinctive features of each CIndU subtype. These suggest involvement of different pathomechanistic pathways in these subtypes that need to be clarified in future studies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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3. EAACI/GA(2)LEN/EDF/WAO guidelines for the definition, classification, diagnosis and treatment of urticaria
- Author
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Zuberbier, T., Aberer, W., Asero, R., Latiff, A. H. Abdul, Baker, D., Ballmer-Weber, B., Bernstein, J. A., Bindslev-Jensen, C., Brzoza, Z., Bedrikow, R. Buense, Canonica, G. W., Church, M. K., Craig, T., Danilycheva V, I., Dressler, C., Ensina, L. F., Gimenez-Arnau, A., Godse, K., Goncalo, M., Grattan, C., Hebert, J., Hide, M., Kaplan, A., Kapp, A., Katelaris, C. H., Kocaturk, E., Kulthanan, K., Larenas-Linnemann, D., Leslie, T. A., Magerl, M., Mathelier-Fusade, P., Meshkova, R. Y., Metz, M., Nast, A., Nettis, E., Oude-Elberink, H., Rosumeck, S., Saini, S. S., Sanchez-Borges, M., Schmid-Grendelmeier, P., Staubach, P., Sussman, G., Toubi, E., Vena, G. A., Vestergaard, C., Wedi, B., Werner, R. N., Zhao, Z., and Maurer, M.
- Published
- 2020
4. 25-hydroxyvitamin D levels are low but not associated with disease activity in chronic spontaneous urticaria and depression
- Author
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Vurgun, E., primary, Memet, B., additional, Kocaturk, E., additional, and Guntas, G., additional
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- 2020
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5. Microalbuminuria as an early marker of renal involvement in Behcet’s disease: it is associated with neurological involvement and duration of the disease
- Author
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Kavala, M, Menteş, F, Kocaturk, E, Ergin, H, Zindanci, I, Can, B, Turkoglu, Z, and Südogan, S
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- 2010
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6. An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis
- Author
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Kavala, M., Sudogan, S., Can, B., Zindanci, İ., Kuru, İ., Beyhan, S., and Kocaturk, E.
- Published
- 2009
7. PO-02-006 Evaluation of Sexual Functions of Female Patients using Systemic Retinoid for Acne Vulgaris Treatment
- Author
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Culha, M., primary, Sahillioglu, N., additional, Degirmentepe, R., additional, Canat, L., additional, Degirmentepe, E., additional, Kocaturk, E., additional, and Otunctemur, A., additional
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- 2019
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8. Recommendations for assessing patient-reported outcomes and health-related quality of life in patients with urticaria: a GA2LEN taskforce position paper
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Baiardini, I. Braido, F. Bindslev-Jensen, C. Bousquet, P. J. and Brzoza, Z. Canonica, G. W. Compalati, E. Fiocchi, A. and Fokkens, W. van Wijk, R. Gerth Gimenez-Arnau, A. Godse, K. and Grattan, C. Grob, J. J. La Grutta, S. Kalogeromitros, D. and Kocaturk, E. Lombardi, C. Mota-Pinto, A. Ridolo, E. and Saini, S. S. Sanchez-Borges, M. Senna, G. E. Terreehorst, I. and Bom, A. Todo Toubi, E. Bousquet, J. Zuberbier, T. and Maurer, M.
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immune system diseases ,parasitic diseases ,skin and connective tissue diseases ,humanities - Abstract
P>The aim of this Global Allergy and Asthma European Network (GA2LEN) consensus report is to provide recommendations and suggestions for assessing patient-reported outcomes (PROs) including health-related quality of life in patients with urticaria. We recommend that PROs should be used both in clinical trials and routine practice for the evaluation of urticaria patients. We suggest that PROs should be considered as the primary outcome of future clinical trials. Two validated and disease-specific instruments for assessing PROs are available, the urticaria activity score (for symptoms) and the chronic urticaria questionnaire on quality of life CU-Q(2)oL. This latter tool, CU-Q(2)oL, is available in many languages and should be preferred, where available, over more generic instruments for assessing urticaria-specific effects on quality of life. CU-Q(2)oL is only suited for the investigation of patients with chronic spontaneous urticaria. Similar instruments for other forms of urticaria have yet to be developed and validated. Also, tools for assessing other chronic spontaneous urticaria PROs besides quality of life and symptoms are needed.
- Published
- 2011
9. Desmoplastic Spitz Naevus Can Be Mistaken for Desmoplastic Malignant Melanoma and Dermatofibroma
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Koc, M, primary, Sudogan, S, additional, Kavala, M, additional, Kocaturk, E, additional, Büyükbabani, N, additional, and Altintas, S, additional
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- 2011
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10. Microalbuminuria as an early marker of renal involvement in Behcet’s disease: it is associated with neurological involvement and duration of the disease
- Author
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Kavala, M, primary, Menteş, F, additional, Kocaturk, E, additional, Ergin, H, additional, Zindanci, I, additional, Can, B, additional, Turkoglu, Z, additional, and Südogan, S, additional
- Published
- 2009
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11. EVALUATION OF SEXUAL FUNCTIONS OF FEMALE PATIENTS USING SYSTEMIC RETINOID FOR ACNE VULGARIS TREATMENT
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Culha, M., Sahillioglu, N., Degirmentepe, R., Lütfi Canat, Degirmentepe, E., Kocaturk, E., and Otunctemur, A.
12. Pityriasis lichenoides-like mycosis fungoides. A case report.
- Author
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Kavala, M., Zindanci, I., Sudogan, S., Buyukbabani, N., Kocaturk, E., Can, B., and Turkoglu, Z.
- Subjects
- *
MYCOSIS fungoides , *T-cell lymphoma , *SKIN diseases , *IMMUNOHISTOCHEMISTRY - Abstract
Mycosis fungoides represents the large majority of primary cutaneous T-cell lymphomas and usually begins as flat erythematous lesions. Pityriasis lichenoides (PL) is an idiopathic dermatosis consisting of recurrent crops of spontaneously regressing papules. Two clinical forms have been described. The acute form (PLEVA) is characterized by gross -5 to 15 mm in size- infiltrated lesions evolving into necrotic crusts, whereas the chronic form (PLC) is characterized by small scaly papules and macules. Cases with clinical features of pityriasis lichenoides together with histopathological findings of mycosis fungoides have been rarely described. We report an 8-year-old girl showing clinical features of PL, in whom the histological, immunohistochemical and T-cell receptor (TCR) rearrangement findings led to the diagnosis of mycosis fungoides. [ABSTRACT FROM AUTHOR]
- Published
- 2010
13. Generalized eruptive histiocytoma in a 12-year-old boy.
- Author
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Can, B., Zindancı, I., Kavala, M., Kocaturk, E., Turkoglu, Z., Koç, M., and Zemheri, E.
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DERMATOFIBROMA , *HISTIOCYTOSIS , *LANGERHANS cells , *BOYS , *DISEASES - Abstract
Generalized eruptive histiocytoma is a rare, benign, papular, self-healing histiocytosis characterized by recurrent crops of small, firm, tan to reddish papules that appear in a symmetrical fashion on the face, trunk and arms. They resolve over months with residual hyperpigmented macules. Although generally regarded as a disorder of adults, generalized eruptive histiocytoma has been seen in childhood. Here is reported a case of generalized eruptive histiocytoma in a 12-year-old male. [ABSTRACT FROM AUTHOR]
- Published
- 2011
14. Depression scores change significantly after omalizumab treatment in patients with chronic spontaneous urticaria.
- Author
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Can PK, Etikan P, Degirmentepe EN, and Kocaturk E
- Subjects
- Humans, Female, Male, Adult, Middle Aged, Treatment Outcome, Surveys and Questionnaires, Omalizumab therapeutic use, Chronic Urticaria drug therapy, Chronic Urticaria psychology, Depression drug therapy, Depression etiology, Anti-Allergic Agents therapeutic use, Quality of Life
- Abstract
Background: Chronic spontaneous urticaria (CSU) is frequently associated with psychiatric comorbidities., Objective: We aimed to determine if depressive symptoms were present in CSU patients who received omalizumab and if depression scores got better with omalizumab treatment and whether the presence of depressive symptoms impaired treatment responses., Methods: CSU patients who received at least three injections of omalizumab were included in the study. Changes in Urticaria Activity Score (UAS), Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), Beck Depression Inventory (Beck-D) and Urticaria Control Test (UCT) scores were compared before and after treatment., Results: From 49 patients, 20 (40.8%) had depressive symptoms at baseline. After treatment, UAS7, CU-Q2oL, Beck-D scores decreased and UCT-scores increased significantly (p < 0.001, for all). UCT scores were lower at baseline and at 3rd month following treatment in patients with depressive symptoms compared to patients without (baseline median (interquartile range-IQR) 2.5 (1-5) vs 5 (2.5-6.5); p = 0.04 and 3rd month 12 (9-13) vs 14 (12-16); p = 0.006, respectively). Omalizumab non-responders had higher baseline Beck-D-scores [18.5 (15.2-22) vs 12 (6-22.5); p = 0.031]. The number of omalizumab non-responders were significantly higher among patients with depressive symptoms compared to patients without. (40% vs 13.8%; p = 0.048). Only 6 patients scored as having depressive symptoms after treatment; of these 6 patients only one was an omalizumab responder., Conclusions: Omalizumab not only provides symptom control for urticaria but also improves psychological conditions of the patients. Coexistent psychiatric comorbidities should be taken into account in CSU patients since these conditions might impair treatment response.
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- 2024
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15. TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.
- Author
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Örnek S, Ozekinci S, Ipin T, and Kocaturk E
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- Humans, Nuclear Proteins metabolism, Prospective Studies, STAT4 Transcription Factor metabolism, Twist-Related Protein 1 metabolism, Matrix Attachment Region Binding Proteins metabolism, Mycosis Fungoides pathology, Skin Neoplasms pathology
- Abstract
Background: Diagnosis of early mycosis fungoides (eMF) is challenging and often delayed as many of its clinical and histopathologic features may mimic various benign inflammatory dermatoses (BIDs). The products of the thymocyte selection-associated high mobility group box (TOX), twist family BHLH transcription factor 1 (TWIST1), signal transducer and activator of transcription 4 (STAT4), and special AT-rich sequence-binding protein 1 (SATB1) genes function as transcription factors and are involved in the pathogenesis of MF., Objectives: We aim to determine the diagnostic value of TOX, TWIST1, STAT4, and SATB1 protein expressions in eMF., Methods: This non-randomized, controlled, prospective analytic study was conducted by performing immunohistochemistry staining with TOX, TWIST1, STAT4, and SATB1 polyclonal antibodies in lesional skin biopsies of eMF and BID patients. Nuclear staining of lymphocytes was compared between eMF and BIDs, and the capacity of these antibodies to predict eMF was determined., Results: Immunostainings with anti-TWIST1 showed an increase in protein expression (p = 0.003) and showed a decrease with anti-SATB1 antibodies in eMF compared to BIDs (p = 0.005) while anti-TOX and anti-STAT4 antibodies did not exhibit significant differences (p = 0.384; p = 0.150). Receiver operating characteristic analysis showed that immunohistochemical evaluations of TWIST1 and SATB1 protein expressions can differentiate eMF (area under the curve [AUC]: 0.728, 95% confidence interval [CI]: 0.605-0.851, p = 0.002; AUC: 0.686, 95% CI: 0.565-0.807, p = 0.013)., Conclusions: TWIST1 and SATB1 are potential diagnostic markers for the histologic diagnosis of eMF., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2024
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16. Diagnostic Values of Immature Granulocytes Detected by the Sysmex XN 9000 Hematology Analyzer in Children with Urinary Tract Infections.
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Cetin N, Kocaturk E, Tufan AK, Kiraz ZK, and Alatas O
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- Humans, Female, Male, Child, Preschool, Infant, Child, Case-Control Studies, Leukocyte Count, Cystitis diagnosis, Cystitis blood, Biomarkers blood, Cicatrix diagnosis, Cicatrix etiology, Urinary Tract Infections diagnosis, Urinary Tract Infections blood, Granulocytes, Vesico-Ureteral Reflux diagnosis, Vesico-Ureteral Reflux blood, Predictive Value of Tests
- Abstract
Immature granulocytes (IGs) are used as markers of infection and systemic inflammation. We aimed to investigate the diagnostic value of IGs in children with urinary tract infections (UTIs). Children with their first UTIs were included in this observational study. Blood samples were obtained before antibiotic therapy. The blood analysis was repeated 2 weeks after the treatment ended. In total, 194 children (95 with febrile UTI, 58 with cystitis, and 41 controls) were included. The percentage of IGs (IG%) and IG count (IGC) measured at the time of admission were higher in the patients with febrile UTI than in the patients with cystitis and the controls (P = 0.000). The IGC and IG% after treatment were higher in patients with renal scarring than in those without scarring (P = 0.012 and P = 0.021, respectively). Cox's regression analysis showed the significant associations of renal scarring with both IGC and IG% (hazard ratio: 8.181, P = 0.002; hazard ratio: 5.106, P = 0.033, respectively). Both IGC and IG% were positively associated with severe vesicoureteral reflux (VUR) [odds ratio (OR): 22.235, P = 0.025; OR: 15.597, P = 0.038, respectively]. In conclusion, the IG% and IGC, which can be easily measured in a routine complete blood count without the need for additional effort, could be used as biomarkers for predicting febrile UTI, renal scarring, and severe VUR in children., (Copyright © 2023 Copyright: © 2023 Saudi Journal of Kidney Diseases and Transplantation.)
- Published
- 2023
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17. Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases.
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Charles N, Kortekaas-Krohn I, Kocaturk E, Scheffel J, Altrichter S, Steinert C, Xiang YK, Gutermuth J, Reber LL, and Maurer M
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- Humans, Basophils, Omalizumab, Autoimmunity, Receptors, IgE metabolism, Immunoglobulin E, Autoimmune Diseases etiology, Autoimmune Diseases therapy, Autoimmune Diseases metabolism
- Abstract
Autoimmunity is the break of tolerance to self-antigens that leads to organ-specific or systemic diseases often characterized by the presence of pathogenic autoreactive antibodies (AAb) produced by plasmablast and/or plasma cells. AAb are prevalent in the general population and not systematically associated with clinical symptoms. In contrast, in some individuals, these AAb are pathogenic and drive the development of signs and symptoms of antibody-mediated autoimmune diseases (AbAID). AAb production, isotype profiles, and glycosylations are promoted by pro-inflammatory triggers linked to genetic, environmental, and hormonal parameters. Recent evidence supports a role for pathogenic AAb of the IgE isotype in a number of AbAID. Autoreactive IgE can drive the activation of mast cells, basophils, and other types of FcεRI-bearing cells and may play a role in promoting autoantibody production and other pro-inflammatory pathways. In this review, we discuss the current knowledge on the pathogenicity of autoreactive IgE in AbAID and their status as therapeutic targets. We also highlight unresolved issues including the need for assays that reproducibly quantify IgE AAbs, to validate their diagnostic and prognostic value, and to further study their pathophysiological contributions to AbAID., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
- Published
- 2023
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18. The many faces of pediatric urticaria.
- Author
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Sekerel BE, Ilgun Gurel D, Sahiner UM, Soyer O, and Kocaturk E
- Abstract
Urticaria is a common disease that can affect individuals of all age groups, with approximately one-quarter of the population experiencing it at least once in their lifetime. Lesions characterized by erythema and itchy hives can appear anywhere on the body. These can vary in size ranging from millimeters to centimeters, and typically clear within 24 h. About 40% of patients with urticaria have accompanying angioedema, which involves localized deep tissue swelling. Urticaria usually occurs spontaneously and is classified into acute and chronic forms, with the latter referring to a condition that lasts for more than 6 weeks. The prevalence of chronic urticaria in the general population ranges from 0.5% to 5%, and it can either be inducible or spontaneous. The most common form of pediatric urticaria is acute and is usually self-limiting. However, a broad differential diagnosis should be considered in children with urticaria, particularly if they also have accompanying systemic complaints. Differential diagnoses of pediatric urticaria include chronic spontaneous urticaria, chronic inducible urticaria, serum sickness-like reaction, urticarial vasculitis, and mast cell disorders. Conditions that can mimic urticaria, including but not limited to cryopyrinopathies, hyper IgD syndrome, Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis (PFAPA), Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPs), and Schnitzler syndrome should also be considered. The many faces of pediatric urticaria can be both easy and confusing. A pragmatic approach relies on clinical foresight and understanding the various forms of urticaria and their potential mimickers. This approach can pave the way for an accurate and optimized diagnostic approach in children with urticaria., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2023 Sekerel, Ilgun Gurel, Sahiner, Soyer and Kocaturk.)
- Published
- 2023
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19. Effect of Puberty, Menstruation, Pregnancy, Lactation, and Menopause on Chronic Urticaria Activity.
- Author
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Ornek SA, Suroji Alkilinc A, Kızıltac U, Kızıltac K, and Kocaturk E
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- Pregnancy, Humans, Female, Menstruation, Breast Feeding, Cross-Sectional Studies, Menopause, Puberty, Gonadal Steroid Hormones, Lactation, Chronic Disease, Chronic Urticaria, Urticaria etiology
- Abstract
Background: Chronic urticaria (CU) is a systemic disorder which is characterized by recurrent wheals and/or angioedema lasting more than 6 weeks. Sex hormones have been suggested to play a role in CU pathogenesis, however, their clinical implications have not been adequately described in the literature., Objective: To determine whether conditions that change sex hormone levels such as puberty, menstruation, pregnancy, breastfeeding, and menopause affect the course of CU., Methods: This cross-sectional questionnaire study was conducted on female CU patients at Okmeydani Training and Research Hospital UCARE Center between 2016 and 2017. The open-ended questionnaire consisted of questions evaluating the effects of hormonal changes on disease course., Results: A total of 111 female CU patients were included in the analysis. During the perimenstrual period, CU symptoms worsened in 29% of patients but improved in 4.8%. The disease course did not change in the majority of patients during puberty, pregnancy, lactation, or menopause (100%, 96%, 83.8%, and 95.6%, respectively)., Conclusions: Contrary to expectations, a change in sex hormone levels had no effect on the course of CU in the majority of cases. However, disease activity increased in one-third of CU patients during the perimenstrual period., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2023
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20. Chronic Spontaneous Urticaria: The Role and Relevance of Autoreactivity, Autoimmunity, and Autoallergy.
- Author
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Asero R, Ferrer M, Kocaturk E, and Maurer M
- Subjects
- Humans, Autoimmunity, Chronic Disease, Urticaria, Chronic Urticaria
- Abstract
Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A large number of studies were performed during the last 2 decades to clarify its pathogenesis. These studies shed light on the underlying autoimmune mechanisms of CSU pathogenesis and have led us to understand that different mechanisms may exist and, sometimes, coexist behind the same clinical presentation. The present article reviews the meaning of the terms autoreactivity, autoimmunity, and autoallergy, which have been variably used over the years to define different endotypes of the disease. Furthermore, we discuss the methods potentially able to lead us to the correct classification of CSU patients., (Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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21. Immature granulocytes as biomarkers of inflammation in children with predialysis chronic kidney disease.
- Author
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Cetın N, Kocaturk E, Tufan AK, Kıraz ZK, and Alatas O
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- Humans, Child, Retrospective Studies, Granulocytes, Leukocyte Count, Biomarkers, Inflammation, Neutrophils, C-Reactive Protein, Renal Insufficiency, Chronic complications
- Abstract
Background: Chronic inflammation in patients with predialysis chronic kidney disease (CKD) is quite common. We aimed to investigate the relationship of the percentage of immature granulocytes (IG%) and immature granulocyte count (IGC) with inflammation in children with predialysis CKD., Methods: The data from children with stage 2-4 CKD and a control group of healthy children were evaluated retrospectively. A highly-sensitive C-reactive protein (hs-CRP) level above 5 mg/dL was considered the presence of inflammation. The IGCs were calculated in the white cell differential channel of the Sysmex XN-9000 using the fluorescent flow cytometry method. The IG% was expressed as percentage of total leucocyte concentration., Results: The data from 57 patients (30 stage 2 CKD, 15 stage 3 CKD, 12 stage 4 CKD) and 46 controls were analyzed. hs-CRP levels, IG%, IGC, white blood cell (WBC) and neutrophil counts, and neutrophil-to-lymphocyte ratio (NLR) were higher in patients than the control group (p < 0.000, p < 0.000, p < 0.000, p = 0.001, p = 0.002, p < 0.000, respectively). Both IG% and IGC were positively correlated with hs-CRP, WBC and neutrophil counts, and NLR (r = 0.485, p < 0.000; r = 0.379, p = 0.004; r = 0.543, p < 0.000; r = 0.628, p < 0.000 for IG%; r = 0.379, p = 0.004; r = 0.351, p = 0.007; r = 0.525, p < 0.000; r = 0.601, p < 0.000 for IGC, respectively). A ROC analysis of the relationship between IGC, IG%, and inflammation showed IGC and IG% had predictive value for the presence of inflammation (cut-off value: 0.035 × 10
6 /mL, AUC: 0.799 ± 0.061, sensitivity: 74.2%, specifity: 63%, p < 0.001 for IGC; cut-off value: 0.45%, AUC: 0.838 ± 0.056, sensitivity: 70.8%, specifity: 67.3%, p = 0.001 for IG%)., Conclusions: Immature granulocytes may be used as a biomarker of inflammation in children with predialysis CKD. A higher resolution version of the Graphical abstract is available as Supplementary information., (© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)- Published
- 2023
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22. Existing and Investigational Medications for Refractory Chronic Spontaneous Urticaria: Safety, Adverse Effects, and Monitoring.
- Author
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Kocaturk E, Saini SS, Rubeiz CJ, and Bernstein JA
- Subjects
- Humans, Chronic Disease, Histamine H1 Antagonists therapeutic use, Omalizumab therapeutic use, Urticaria drug therapy, Urticaria chemically induced, Chronic Urticaria drug therapy, Drug-Related Side Effects and Adverse Reactions drug therapy
- Abstract
Treatment of chronic spontaneous urticaria (CSU) is responsive to H1 antihistamines administered up to four times the recommended US Food and Drug Administration dose in approximately 50% of patients. However, when patients do not respond to these first-line agents, evidence-based guidelines using Grading of Recommendations, Assessment, Development, and Evaluations methodology have provided direction for second- and third-line treatments that can effectively treat patients with CSU. Some patients remain refractory to these advanced treatments; therefore, alternative treatments with a lower certainty of evidence may be necessary. Regardless of the therapies used to treat CSU patients, it is essential for clinicians to be knowledgeable about the mechanism of action, efficacy, and safety and monitoring recommendations of the treatments prescribed. This review provides a comprehensive review of the adverse effects and monitoring recommendations for agents in use for CSU treatment as well as those currently undergoing investigation for CSU treatment., (Copyright © 2022 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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23. An evaluation of remission rates with first and second line treatments and indicators of antihistamine refractoriness in chronic urticaria.
- Author
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Ayse Ornek S, Orcen C, Church MK, and Kocaturk E
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- Humans, Leukotriene Antagonists therapeutic use, Retrospective Studies, Histamine H1 Antagonists therapeutic use, Histamine Antagonists therapeutic use, Chronic Disease, Omalizumab therapeutic use, Chronic Urticaria drug therapy, Histamine H1 Antagonists, Non-Sedating therapeutic use
- Abstract
Background: Guidelines recommend standard doses of antihistamines as first-line, and updosing of antihistamines as second-line treatment for the management of chronic urticaria (CU). However, remission rates with different types of first- and second-line treatments and indicators of antihistamine response are largely lacking in the literature., Objectives: To examine response rates to first- and second-line treatments in CU, and to identify patient characteristics that can predict antihistamine treatment outcomes., Methods: We retrospectively analyzed treatment outcomes of 657 CU (556 chronic spontaneous urticaria (CSU), 101 chronic inducible urticaria (CIndU)) patients who had at least 3-months of follow-up data., Results: A standard dose of second generation antihistamines (sgAH) was effective in 43.1 % of the patients. An additional 28.8 % of patients were in remission with second-line treatments. Among patients whose disease was in remission with a standard dose of sgAHs, 14.8 % benefited from switching from their current sgAH to another sgAH. Updosing sgAHs, combination of two different sgAHs, sgAH and first generation H
1 -antihistamine combination, and sgAH and leukotriene receptor antagonist combination provided remission in 38.3 %, 35.8 %, 37.5 % and 25 % of patients who were given these treatments, respectively. Baseline UCT score ≤ 4, emergency referral and family history of CSU were found to be risk factors for antihistamine refractoriness in patients with CSU., Conclusions: A step-wise approach to the management of CU is practical as more patients respond to treatment at each step. The presence of baseline UCT score ≤ 4, emergency referral and family history of CSU might be helpful to determine patients who require third-line treatments in advance., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)- Published
- 2022
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24. Serum clusterin levels are not associated with chronic spontaneous urticaria regardless of serum lipids.
- Author
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Vurgun E, Memet B, Etikan P, Guntas G, and Kocaturk E
- Subjects
- Chronic Disease, Clusterin, Humans, Lipids, Chronic Urticaria, Urticaria
- Abstract
Background: Clusterin is related to immunity and inflammation via regulation of complement activation and bidirectional regulation, and by major proinflammatory cytokines. Clusterin levels have been the subject of a few research both in patients with hyperlipidemia and those with chronic spontaneous urticaria (CSU) separately. The aims of this study were to evaluate the levels of clusterin levels and serum lipids and the relationships between them in patients with CSU., Methods: Fifty patients with CSU and 30 healthy controls were enrolled into the study. The activity of urticaria of the patients was determined by urticaria activity score (UAS7). Serum clusterin, total cholesterol, HDL, LDL and triglyceride levels of the participants were measured and compared. The relationships between UAS, lipids and clusterin were examined., Results: There was no difference in clusterin levels between CSU patients and controls. Clusterin level was not related to activity of urticaria. Clusterin levels were not correlated with any of lipid parameters neither in CSU patients nor in controls., Conclusions: Findings of this study show that clusterin levels do not change due to CSU. Serum clusterin levels cannot be used as a diagnostic or a disease activity marker in CSU patients, regardless of the lipid profile.
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- 2022
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25. Cellular immunity in subacute thyroiditis: a new perspective through neopterin.
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Sahin Tekin M, Kocaturk E, Gurcu S, Kayadibi H, Dibeklioglu B, and Yorulmaz G
- Subjects
- Humans, Immunity, Cellular, Interferon-gamma, Neopterin, T-Lymphocytes, Helper-Inducer, Thyroiditis, Subacute
- Abstract
Subacute thyroiditis (SAT) is an inflammatory disorder of the thyroid gland. Although its etiology is not fully understood, it is believed to occur shortly after viral infections and is mostly associated with human leukocyte antigen (HLA)-B*35. Cellular immunity is prominent in SAT. Neopterin is produced by activated monocytes/macrophages and is a marker of cellular immunity. Its production is stimulated by interferon gamma (IFN-γ), provided mainly by activated helper T lymphocytes type 1 (Th1) in the adaptive immune system. Therefore, with these cells' activation, an increase in serum neopterin levels is expected. We aimed to evaluate neopterin levels in demonstrating cellular immunity in SAT and compared 15 SAT patients with 16 healthy controls. Since all SAT patients were in the active thyrotoxic phase, we found a significant difference in thyroid functions. Classical inflammatory markers, erythrocyte sedimentation rate, and C-reactive protein were markedly elevated in the patient group. Although we expected to find an increase considering that cellular immunity is at the forefront in the pathogenesis of SAT, we found serum neopterin levels significantly lower in the patient group than in the control group. There is an increase in CD8+ T cells in the thyroid tissue in SAT. The possible relationship with HLA-B*35- major histocompatibility complex class I in SAT, and the antigen presentation to CD8+ T cells may be the reason why we observed low serum neopterin levels in patients due to the cytokine imbalance. Neopterin provides unique and independent data from classical acute phase response indicators., (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2022
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26. Investigation of the relationship of CO-RADS and CT patterns with laboratory parameters in COVID-19 patients and a new perspective on the total CT scoring system.
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Aydin N, Yildiz P, Cansu DÜ, Gündogdu E, Mutluay R, Yorulmaz G, Tekin MS, Kocaturk E, Alatas IÖ, Kartal ED, Erben N, Durmaz G, Kasifoglu N, Us T, Sahin G, Bal C, Yilmaz S, and Korkmaz C
- Subjects
- Creatinine, Humans, Lung diagnostic imaging, Retrospective Studies, Tomography, X-Ray Computed methods, COVID-19 diagnostic imaging
- Abstract
Background: It is important to determine the correlation of the CO-RADS classification and computed tomography (CT) patterns of the lung with laboratory data. To investigate the relationship of CO-RADS categories and CT patterns with laboratory data in patients with a positive RT-PCR test. We also developed a structured total CT scoring system and investigated its correlation with the total CT scoring system., Method: The CT examinations of the patients were evaluated in terms of the CO-RADS classification, pattern groups and total CT score. Structured total CT score values were obtained by including the total CT score values and pattern values in a regression analysis. The CT data were compared according to the laboratory data., Results: A total of 198 patients were evaluated. There were significant differences between the CO-RADS groups in terms of age, ICU transfer, oxygen saturation, creatinine, LDH, D-dimer, high-sensitivity cardiac troponin-T (hs-TnT), CRP, structured total CT score values, and total CT score values. A significant difference was also observed between the CT pattern groups and oxygen saturation, creatinine and CRP values. When the structured total CT score values and total CT score values were compared they were observed to be correlated., Conclusions: Creatinine can be considered as an important marker for the CO-RADS and pattern classifications in lung involvement. LDH can be considered as an important marker of parenchymal involvement, especially bilateral and diffuse involvement. The structured total CT scoring system is a new system that can be used as an alternative., (© 2022. The Author(s).)
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- 2022
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27. Chronic urticaria and COVID-19 vaccination: Qatar data (preliminary report of COVAC-CU-international).
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Purayil S, Thalappil S, Al-Nesf M, and Kocaturk E
- Abstract
Background: It is a well-known fact that patients with chronic urticaria (CU) are not at a higher risk for a serious allergic reaction such as anaphylaxis from medications. However, there is a fear and some misconceptions regarding allergic reactions to the COVID-19 vaccine among patients and physicians, which might result in resistance to vaccination. Data about the incidence and severity of COVID-19 vaccine reactions in the CU population are scarce. In this study, we aimed to evaluate the real-world (Qatar) experience of the effects of COVID-19 vaccination on patients with CU and analyze the rates of vaccine-associated reactions and risk factors associated., Methods: This is a cross-sectional questionnaire-based study conducted as a part of COVAC-CU international under the GALEN UCARE program. Adult patients with CU who received one or more doses of COVID-19 vaccination were administered a questionnaire regarding their demographic characteristics and any potential unfavorable effect of the vaccination from the November 03 to December 31, 2021., Results: These are preliminary results from an ongoing study. The data were collected from 91 patients with CU, of whom 79.12% had chronic spontaneous urticaria, 15.3% had chronic inducible urticaria, and the remaining had both. Of these patients, 74.7% were women. The average age of the patients was 39.3 (range 15-68) years. The majority (84.6%) of them received 2 vaccine doses, 13.1% received 3 doses, and the remaining received 1 dose. Most (70.3%) of these patients did not experience any worsening in CU after vaccination. A total of 62.6% patients reported some type of side effects to the vaccine (16.4% had CU exacerbation and 46.1% other types of reactions, such as fever and muscle pain). None of the patients reported anaphylaxis. Two patients reported improvement in their symptoms., Conclusion: Our local data suggest that patients with CU in Qatar can safely take the COVID-19 vaccine. Most patients with CU did not experience any worsening in symptoms, and there were no reports of a severe reaction (anaphylaxis). We recommend maximizing symptom control prior to vaccination to minimize the risk of worsening urticarial symptoms., (© 2022 Purayil, Thalappil, Al-Nesf, Kocaturk, licensee HBKU Press.)
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- 2022
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28. A patient-oriented approach to long-term use of omalizumab in chronic spontaneous urticaria.
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Ornek S and Kocaturk E
- Subjects
- Adult, Anti-Allergic Agents adverse effects, Chronic Urticaria diagnosis, Chronic Urticaria immunology, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Omalizumab adverse effects, Retrospective Studies, Skin Tests, Treatment Outcome, Young Adult, Anti-Allergic Agents administration & dosage, Chronic Urticaria drug therapy, Omalizumab administration & dosage
- Abstract
Background: Omalizumab is an effective and safe treatment for antihistamine resistant chronic spontaneous urticaria (CSU), however, long-term efficacy and safety remains unclear., Objective: To evaluate the efficacy and safety of omalizumab in CSU patients treated for long term and to identify long-term management strategies., Methods: We retrospectively analyzed demographic characteristics, clinical features, laboratory parameters and treatment outcomes of 41 CSU patients who received omalizumab for at least 3 years. Treatment responses were evaluated with urticaria control test (UCT). Treatment safety was evaluated by comparing laboratory findings before and three years after omalizumab initiation as well as considering patients' adverse event reports., Results: The patients (mean age 40.46 years; 63.4% women) received omalizumab for an average of 41.93 months (mean 31.68 injections/patient). The mean baseline UCT score was 5.56 and average number of injections to reach UCT score ≥12 was 3.3. Nine patients (22%) responded insufficiently to 300 mg/4 weeks omalizumab and required updosing. Thirty-eight patients (92.7%) could tolerate longer dose intervals (>4 weeks) and the dose interval was increased after a mean of 11.53 injections. There was no loss of efficacy of omalizumab. Sixteen patients (39%) had been retreated with omalizumab after a mean discontinuation time of 24 weeks. Five patients (12.2%) reported mild and transient adverse effects. Liver and renal function tests as well as full blood count before and after omalizumab were in normal ranges., Conclusion: For the long-term management of CSU, omalizumab is a safe and effective treatment which can be tailored according to patients' disease activity.
- Published
- 2021
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29. Patch Test Results to European Baseline Series in Turkey: A Prospective and Multicenter Study.
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Koca R, Kocaturk E, Savk E, Baskan EB, Aydin F, Yalcin B, Gul U, Akdeniz S, Bilen H, Alper S, Aktan S, Utas S, and Kokturk F
- Subjects
- Allergens adverse effects, Humans, Prevalence, Prospective Studies, Turkey, Allergens administration & dosage, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact epidemiology, Patch Tests standards
- Abstract
Background: Patch testing with the European Baseline Series (EBS) is an essential diagnostic tool for the assessment of allergic contact dermatitis., Objective: The aims of the study were to describe the most common contact allergens identified with patch testing in Turkey and to establish the distribution of contact allergens among different regions in Turkey., Patients and Methods: Twelve centers consisting of tertiary health care institutions were included in the study. A total of 1169 patients were patch tested with the EBS from 2015 to 2017., Results: A total of 596 patients (51.0%) had 1 or more positive patch test reactions to the EBS. A total of 30.2% (n = 353) of those tested had clinical relevance. Contact sensitivity was more common in young patients. The most common 10 allergens were nickel sulfate (20.4%), followed by textile dye mix (8.6%), cobalt chloride (8.3%), potassium dichromate (8.0%), p-phenylenediamine base (4.5%), balsam of Peru (4.3%), methylchloroisothiazolinone/methylisothiazolinone (3.8%), thiuram mix (3.6%), fragrance mix I (3.0%), and methylisothiazolinone (2.9%)., Conclusions: This study provides a comprehensive profile of patch test results with the EBS in Turkey. An ongoing decrease in contact allergy to methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone was observed. Textile dye mix and p-phenylenediamine are beginning to pose a new risk in Turkey., Competing Interests: The authors have no funding or conflicts of interest to declare., (Copyright © 2021 American Contact Dermatitis Society. All Rights Reserved.)
- Published
- 2021
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30. Assessment of disease activity and quality of life in patients with recurrent bradykinin-mediated versus mast cell-mediated angioedema.
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Can PK, Degi Rmentepe EN, Etikan P, Kiziltaç K, Gelincik A, Demir S, Buyukozturk S, Haşal E, Bülbül Başkan E, Aydin Ö, Maurer M, Weller K, and Kocaturk E
- Abstract
Objective: Recurrent Angioedema (RAE) is characterized by sudden swelling of mucosal surfaces or deep dermis and is either mast cell-(MMAE) or bradykinin-mediated (BMAE). How patients with BMAE and MMAE differ in terms of disease activity and impact remains largely unknown. Here, we determined validity, reliability, and sensitivity to change of Turkish versions of angioedema activity score (AAS) and quality of life questionnaire (AE-QoL) and used both instruments to investigate and compare patients with BMAE and MMAE., Methods: Turkish versions of AAS28 and AE-QoL were applied to 94 patients with RAE (18-72 years). Patients' global self-assessment of QoL (PGA-QoL), disease activity (PGA-DA-VRS, PatGA-DA-VAS), and 12-Item-Short Form Survey were used at week 4 (visit 2), and week 8 (visit 3). Demographic characteristics, clinical features, and AAS28 and AE-QoL values were compared between 31 patients with BMAE and 63 patients with MMAE., Results: Turkish AAS28 and AE-QoL showed excellent internal consistency, high reproducibility and known-groups validity. Compared to patients with MMAE, BMAE patients were younger (34.6 ± 10.7 vs. 40.7 ± 13.3 years), had longer disease duration (236 ± 178 vs. 51 ± 78 months), high prevalence of family history (63% vs 14%), longer duration of attacks (65 ± 20 vs. 40 ± 25 h), and they were more commonly affected by upper airway angioedema (70% vs 23%). Disease activity (AAS28) was lower (29.3 ± 24.6 vs 55.2 ± 52.9), but AE-QoL was higher (44.2 ± 16.1 vs 34.5 ± 22.5) in BMAE patients as compared to MMAE patients., Conclusions: Patients with BMAE and MMAE have distinct disease characteristics. Recurrent bradykinin-mediated angioedema impacts quality of life more than mast cell-mediated angioedema. The discriminating characteristics of patients with BMAE and MMAE may help to improve the diagnosis and management of patients with RAE., Competing Interests: Emek Kocaturk reports advisory board fees from 10.13039/100004336Novartis, and has served as a medical advisor for 10.13039/100004326Bayer, Menarini and 10.13039/100004339Sanofi. Marcus Maurer is or recently was a speaker and/or advisor for and/or has received research funding from Allakos, 10.13039/100002429Amgen, Aralez, ArgenX, Astra Zeneca, 10.13039/100012431Celldex, Centogene, 10.13039/100008322CSL Behring, 10.13039/100016525FAES, 10.13039/100004328Genentech, GIInnovation, Innate Pharma, 10.13039/100016348Kyowa Kirin, Leo Pharma, 10.13039/100004312Lilly, Menarini, Moxie, 10.13039/100004336Novartis, 10.13039/100004337Roche, 10.13039/100004339Sanofi/10.13039/100009857Regeneron, Third HarmonicBio, 10.13039/100011110UCB, and Uriach. Karsten Weller is or recently was a speaker and/or advisor for and/or has received research funding from Biocryst, 10.13039/100008322CSL Behring, Moxie, 10.13039/100004336Novartis, Shire/10.13039/100007723Takeda, and Uriach. The other authors have no conflict of interest to declare., (© 2021 The Authors.)
- Published
- 2021
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31. A new approach for diagnosing hematological malignancies using monocytosis workflow optimization and abnormal lymphocyte/blast flag of Sysmex XN series of blood count analyzers.
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Kocaturk E, Kusku Kiraz Z, Uskudar Teke H, Demir SS, and Alatas IO
- Subjects
- Aged, Automation, Laboratory, Female, Humans, Leukocyte Count instrumentation, Leukocyte Count methods, Leukocyte Count standards, Male, Middle Aged, Prospective Studies, Hematologic Neoplasms blood, Hematologic Neoplasms diagnosis, Lymphocytes metabolism
- Abstract
Introduction: Monocytosis Workflow Optimization rule set has been developed by using mono-dysplasia-score to determine reactive monocytosis and prevent unnecessary blood smear of these patients and for detection of chronic myelomonocytic leukemia cases during complete blood count. In our study, we aimed to examine the contribution of Monocytosis Workflow Optimization rule set., Methods: Adult patients with monocyte count ≥1.0 10
3 /µL and monocyte percentage ≥10% were included in our study. Blood smears were made from the samples in our laboratory. These smears were examined and patients were divided into two groups as reactive monocytosis or hematological malignancy. The groups were compared in terms of Monocytosis Workflow Optimization rule set and device flags., Results: Twenty-one patients had hematological malignancies of 155 patients who were included in our study. Monocytosis Workflow Optimization rule set suggested performing blood smear in 19 of the patients with hematological malignancy, and evaluated two patients as reactive monocytosis with 90.5% sensitivity and 76.9% specificity. There was an "abnormal lymphocyte/ blast" flag in 90.5% of patients with hematological malignancies and in patients whose Monocytosis Workflow Optimization rule set defined as reactive monocytosis and it was found that sensitivity and negative predictive value reached 100%., Conclusion: Automated validation support systems and softwares developed especially for these systems make it possible to classify patients with their non-specific findings, as a result both contributing to the reduction of laboratory workload and costs and assisting laboratory specialists and clinicians with adding value to laboratory results., (© 2020 John Wiley & Sons Ltd.)- Published
- 2020
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32. 25-hydroxyvitamin D levels are low but not associated with disease activity in chronic spontaneous urticaria and depression.
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Vurgun E, Memet B, Kocaturk E, and Guntas G
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- Calcifediol, Case-Control Studies, Humans, Vitamin D metabolism, Vitamin D Deficiency, Chronic Urticaria metabolism, Depression metabolism, Vitamin D analogs & derivatives
- Abstract
Aim: To evaluate vitamin D levels in patients with chronic spontaneous urticaria (CSU), depression and both of them, thus to find out whether vitamin D may be a common causative factor of CSU and depression., Methods: Thirty patients with CSU, 30 patients with depression, 30 patients with both CSU and depression and 30 healthy volunteers as control group were involved in the study. Serum 25-hydroxyvitamin D (25(OH)D) levels of these groups were measured and compared. Correlations between 25(OH)D levels and the activity of CSU and depression were analyzed., Results: Healthy controls' 25(OH)D levels (17.2±8.8 ng/mL) were higher than patients with CSU (9.1±5.1 ng/mL), depression (8.9±6.1 ng/mL) and CSU with depression (7.7±4.7 ng/mL) (p<0.001, p<0.001 and p<0.001, respectively). There were no differences in 25(OH)D levels between CSU patients with and without depression, between depression patients and CSU patients with and without depression (p=0.43, p=0.82 and p=0.92, respectively). There were no correlations between 25(OH)D levels and the activity of CSU or depression (p=0.99 and p=0.76, respectively)., Conclusion: Lower 25(OH)D levels in CSU and/or depression may appear as a secondary phenomenon, which means being result of these diseases rather than the cause (Tab. 1, Fig. 2, Ref. 41). Text in PDFwww.elis.sk Keywords: vitamin D, vitamin D deficiency, chronic urticaria, depression.
- Published
- 2020
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33. Omalizumab as a Succesfull Therapy in Normocomplementemic Urticarial Vasculitis: A Series of Four Patients and Review of the Literature.
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Degirmentepe EN, Kızıltac K, Etikan P, Singer R, Memet B, and Kocaturk E
- Abstract
Urticarial vasculitis is an eruption characterized by inflamed itchy or painful red papules or plaques that resemble urticaria but last longer than 24 hours and heal with residual pigmentation or purpura. Histopathologically, urticarial vasculitis presents as leukocytoclastic vasculitis with perivascular infiltrate and fibrin deposits. The treatment options are oral antihistamines, oral corticosteroids, dapsone, colchicine and hydroxychloroquine. We report four cases with normocomplementemic urticarial vasculitis who were treated with omalizumab and a brief review of the literature on the use of omalizumab in normocomplementemic urticarial vasculitis., Competing Interests: CONFLICTS OF INTEREST: The authors have nothing to disclose., (Copyright © 2019 The Korean Dermatological Association and The Korean Society for Investigative Dermatology.)
- Published
- 2019
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34. Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index.
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Can PK, Etikan P, Kızıltaç U, Kızıltaç K, Singer R, and Kocaturk E
- Subjects
- Adolescent, Adult, Aged, Diagnostic Tests, Routine, Disease Management, Female, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Severity of Illness Index, Urticaria therapy, Young Adult, Quality of Life, Urticaria diagnosis, Urticaria epidemiology
- Abstract
Background: Fric test is a useful tool for the diagnosis and threshold testing for symptomatic dermographism. When threshold testing is not available, Urticaria Control Test (UCT) and Dermatology Life Quality Index (DLQI) might be used to assess disease control and quality of life (QoL) impairment, respectively., Objectives: In this study, we aimed to describe a new scoring system for the Fric test and evaluate the correlations of Fric scores with UCT, DLQI, and other disease activity assessment scores., Method: Provocation test with Fric Test 4.0 was performed in all patients at referral and at the 4th week. We considered a 4-grade rating score for Fric Test (0-4) [Total Fric Score (TFS)]. A positive response with all of the four pins suggested severe dermographism (TFS = 4), while a wheal with only the largest pin (4.5 mm) was considered as milder disease (TFS = 1). Treatment responses were evaluated with Fric Test 4.0, UCT, patient's global assessment of disease severity (PatGA-VAS), the physician's global assessment of disease control (PhyGA-VAS), and DLQI at baseline and at the 4th week of treatment. The correlations of TFS with UCT, DLQI, PatGA-VAS, PhyGA-VAS at baseline as well as the changes in the mean scores after treatment (week 4) were performed., Results: The mean UCT and DLQI scores were 8.69 ± 3.40 and 7.88 ± 6.02 at the first visit. At the second visit, TFS decreased from a mean of 2.79 ± 1.68 to 1.91 ± 1.85 (p < 0.001), and UCT scores and PhyGA-VAS were increased (p < 0.001), while DLQI scores, PatGA-VAS, and pruritus scores decreased significantly (p = 0.002; p = 0.001; p = 0.012). There was a positive correlation between TFS and pruritus scores (r = 0.378) and DLQI scores (r = 0.392). TFS was found to have a negative correlation with UCT score (r = -0.283) and PhyGA-VAS (r = -0.347)., Conclusions: This new Fric scoring system allows comparison with other tools and shows moderate correlations with most of the tools. Using disease-specific tools is recommended since they provide a subjective evaluation of disease severity, QoL impairment, and disease control., (© 2018 S. Karger AG, Basel.)
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- 2019
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35. Assessment of quality of life in Turkish children with psoriasis and their caregivers.
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Tekin B, Gurel MS, Topkarci Z, Topaloglu Demir F, Aytekin S, Cebeci Kahraman F, Singer R, Erdemir VA, Uzuncakmak TK, Yasar S, Akdeniz N, Altunay IK, Kocaturk E, Turkoglu Z, and Erdogan B
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Male, Surveys and Questionnaires, Turkey, Caregivers psychology, Patients psychology, Psoriasis psychology, Quality of Life psychology
- Abstract
Background/objectives: The effect of pediatric psoriasis on quality of life has been demonstrated, but data regarding its influence on caregiver quality of life are scarce. The objective was to investigate how psoriasis affects quality of life of children and their caregivers., Methods: This multicenter study included 129 children with psoriasis and their caregivers, who were family members accompanying patients to the clinic. Patient quality of life was measured using the Child Dermatology Life Quality Index. Caregiver quality of life was assessed using Dermatological Family Impact Scale, a 15-item questionnaire validated for use in the Turkish language., Results: Mean Child Dermatology Life Quality Index score was 7.6, indicating a moderate effect on patient quality of life. Symptoms and feelings were the most severely impaired domains of patient quality of life, and emotions was the most severely impaired domain of caregiver quality of life. Dermatological Family Impact Scale score was significantly correlated with Child Dermatology Life Quality Index (correlation coefficient [r] = .554, P < .001) and Psoriasis Area and Severity Index (r = .350, P < .001). Caregivers of patients receiving systemic agents or phototherapy had relative impairment of multiple domains of quality of life compared to caregivers of patients receiving topical treatment only., Conclusion: Psychosocial effect of pediatric psoriasis was shown to extend beyond the individual, highlighting the importance of addressing patient and caregiver quality of life concerns in an integrated approach., (© 2018 Wiley Periodicals, Inc.)
- Published
- 2018
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36. Evaluation of the quality of life in patients with arsenic keratosis.
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Namdar ND, Arikan I, Kahraman C, Kocaturk E, Dagci M, and Ece E
- Subjects
- Adult, Aged, Aged, 80 and over, Anxiety, Depression, Female, Humans, Male, Middle Aged, Pain Measurement, Young Adult, Arsenic Poisoning, Keratosis, Quality of Life
- Abstract
Background: Chronic exposure to inorganic arsenic is an important public health problem and leads to hyperpigmentation, hyperkeratosis, Bowen's disease and non-melanoma skin cancers in humans. Arsenic keratosis is the most common skin change that is associated with arsenic exposure. It may be an indicator of arsenic induced health hazards., Objective: To determine the needs of patients with arsenic keratosis by evaluating the impact of disease on the quality of life with respect to treatment and provide rehabilitation services., Methods: A total of 47 subjects with arsenic hyperkeratosis, were enrolled in this crossover study. The demographics, smoking status and the presence of chronic diseases diagnosed by the physician were recorded. Weight and height of the subjects were measured and BMI was calculated. The patients were asked to respond the visual analogue scale and EuroQoL-5D scales for assessing the pain and quality of life impairment associated with arsenic hyperkeratosis., Results: In the study group, moderate to severe problems were reported in 78.7% of patients for pain/uncomfortable condition domains and in 91.5% in anxiety/depression domains. Lower quality of life was reported in those with associated chronic disorders, at an advanced age, in thin patients and in those with severe lesions., Conclusion: According to our knowledge, our study is the first one measuring the quality of life in patients with arsenic keratosis in the literature. By this study, we tried to underline the guidance of health services to be developed towards the needs of patients and the need for the development of new health policies by determining the requirements of these patients.
- Published
- 2018
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37. Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea.
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Erdogan HK, Bulur I, Kocaturk E, Saracoglu ZN, Alatas O, and Bilgin M
- Abstract
Introduction: Rosacea is a chronic, inflammatory dermatosis which develops due to the effect of genetic and environmental factors., Aim: To evaluate the oxidative stress in rosacea patients by measuring serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and advanced oxidation protein products (AOPP) levels in our study., Material and Methods: Our study included rosacea patients and healthy volunteers aged between 18 and 65 years. Total antioxidant status, TOS and AOPP levels were measured and OSI was calculated., Results: The study included 70 rosacea patients and 30 healthy volunteers as a control group. When TAS, TOS, OSI and AOPP levels were compared between rosacea and control groups, there was no difference for OSI levels; while TAS, TOS and AOPP levels were significantly higher in the rosacea group ( p = 0.151, p = 0.013, p = 0.034, p = 0.017, respectively). In the rosacea group, there was no correlation between TAS, TOS, OSI and AOPP levels and disease duration. Besides there was no difference between family history, rosacea type, symptom frequency and ocular involvement and TAS, TOS, OSI and AOPP levels in the rosacea group., Conclusions: We observed that serum TAS, TOS and AOPP levels were significantly higher in rosacea patients, but there was no significant difference among the disease activity parameters. These results can support the role of oxidative stress in the pathogenesis of rosacea., Competing Interests: The authors declare no conflict of interest.
- Published
- 2018
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38. The role of oxidative stress in early-onset androgenetic alopecia.
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Kaya Erdogan H, Bulur I, Kocaturk E, Yildiz B, Saracoglu ZN, and Alatas O
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- Adult, Age of Onset, Case-Control Studies, Humans, Male, Young Adult, Alopecia blood, Antioxidants metabolism, Oxidants blood, Oxidative Stress
- Abstract
Background: Androgenetic alopecia (AGA) is the most common cause of alopecia in men. In the literature, although there are in vitro studies investigating the relationship between oxidative stress and AGA, any in vivo study does not exist., Aim: Our aim was to evaluate the oxidative stress status in male patients with early-onset AGA by measuring total oxidant levels (TOS), total antioxidant levels (TAS), and oxidative stress index (OSI)., Methods: Our study included 33 male patients with early-onset AGA and 30 healthy men between ages of 18 and 30 years old. TAS and TOS measurements were taken, and OSI was calculated., Results: When TAS, TOS, and OSI levels were compared between patient and control groups, there was no difference for TAS level, while TOS and OSI were significantly higher in patient group. In patient group, correlation between TAS, TOS, and OSI levels and age, and disease onset age and disease duration was evaluated. Highly significant negative correlation was determined between TAS level and both age and disease duration. When TAS, TOS, and OSI levels were assessed according to AGA stage, there was no significant difference between groups, while OSI level was significantly higher in patients with family history., Conclusions: We found increased oxidative stress in younger patients with early-onset AGA. There is need for further molecular studies on the role of oxidative stress in the etiopathogenesis of AGA. We also think that topical or systemic antioxidants can be promising in treatment of AGA, especially for young patients., (© 2016 Wiley Periodicals, Inc.)
- Published
- 2017
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39. Dermatologic manifestations of acromegaly: A case in point and a focused review.
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Degirmentepe EN, Gungor S, Kocaturk E, Kiziltac U, Adas M, Ozekinci S, and Khachemoune A
- Subjects
- Acanthosis Nigricans etiology, Adult, Growth Hormone metabolism, Growth Hormone-Secreting Pituitary Adenoma metabolism, Hidradenitis Suppurativa etiology, Humans, Insulin-Like Growth Factor I metabolism, Male, Scalp Dermatoses etiology, Skin Diseases physiopathology, Acromegaly etiology, Growth Hormone-Secreting Pituitary Adenoma complications, Skin Diseases etiology
- Abstract
Acromegaly is a systemic syndrome caused by overproduction of growth hormone. Cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems are affected. Cutaneous changes in acromegaly relate to overexpression of growth hormone and insulin-like growth factor 1 on skin cells and adnexa. Dermal glycosaminoglycan accumulation and edema cause skin distention that is most prominent in the face, hands, and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered. Cutaneous manifestations of acromegaly are various and prominent, and are an important clue for the early diagnosis and treatment of this high-morbidity disorder.
- Published
- 2017
40. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation.
- Author
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Duman H, Topal IO, Kocaturk E, Cure K, and Mansuroglu I
- Subjects
- Acute Generalized Exanthematous Pustulosis diagnosis, Adult, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Female, Humans, Hydroxychloroquine therapeutic use, Acute Generalized Exanthematous Pustulosis etiology, Antirheumatic Agents adverse effects, Hydroxychloroquine adverse effects
- Abstract
Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. A 42-year-old female presented with pustular lesions on the skin surface with erythema, facial edema, and occasional atypical target-like lesions after 21 days of treatment with 200mg/day hydroxychloroquine for rheumatoid arthritis, diagnosed one month previously. We report a case with acute generalized exanthematous pustulosis induced by hydroxychloroquine and treated with dapsone and systemic corticosteroid.
- Published
- 2017
- Full Text
- View/download PDF
41. Follicular traction urticaria.
- Author
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Duman H, Topal IO, and Kocaturk E
- Subjects
- Adult, Chronic Disease, Female, Humans, Time Factors, Hair Follicle pathology, Hair Removal adverse effects, Urticaria etiology, Urticaria pathology
- Abstract
Inducible urticaria is a heterogeneous subgroup of chronic urticarias caused by a wide variety of environmental stimuli, such as exercise, cold, heat, pressure, sunlight, vibration, and water. A new term, follicular traction urticaria, was suggested as an unusual form of inducible urticarias. We report a patient who was diagnosed with follicular traction urticaria.
- Published
- 2016
- Full Text
- View/download PDF
42. Oleogranulomas of the breast treated with hydroxychloroquine.
- Author
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Topal IO, Kocaturk E, Duman H, and Topal Y
- Subjects
- Adult, Antirheumatic Agents therapeutic use, Granuloma, Foreign-Body chemically induced, Humans, Male, Plant Oils administration & dosage, Sunflower Oil, Treatment Outcome, Breast drug effects, Breast pathology, Granuloma, Foreign-Body diagnosis, Granuloma, Foreign-Body drug therapy, Hydroxychloroquine therapeutic use, Plant Oils adverse effects
- Published
- 2016
- Full Text
- View/download PDF
43. Coexistence of granuloma annulare and chronic spontaneous urticaria.
- Author
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Topal IO, Gungor S, Nayır PO, Kocaturk E, and Yuksel T
- Subjects
- Biopsy, Chronic Disease, Female, Granuloma Annulare immunology, Humans, Middle Aged, Skin pathology, Urticaria immunology, Granuloma Annulare complications, Granuloma Annulare pathology, Urticaria complications, Urticaria pathology
- Abstract
Competing Interests: None.
- Published
- 2016
- Full Text
- View/download PDF
44. Benign Nerve Sheath Myxoma in an Infant Misdiagnosed as Infantile Digital Fibromatosis.
- Author
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Güngör Ş, Şişman S, Kocaturk E, Oguz Topal I, and Yıldırım S
- Subjects
- Diagnosis, Differential, Diagnostic Errors, Humans, Infant, Male, Neurothekeoma surgery, Skin Neoplasms surgery, Toes pathology, Fibroma diagnosis, Neurothekeoma diagnosis, Skin Neoplasms diagnosis
- Abstract
Herein we present the case of a 16-month boy, clinically diagnosed with infantile digital fibromatosis, but 9 months after continued growth, the mass was excised and the histopathologic diagnosis was that of a benign nerve sheath myxoma. We present this case to emphasize that nerve sheath myxomas (also known as myxoid neurothekeoma) should be included in the differential diagnosis of dermal nodules in infants., (© 2016 Wiley Periodicals, Inc.)
- Published
- 2016
- Full Text
- View/download PDF
45. Evaluation of the Clinical and Sociodemographic Features of Turkish Patients with Vitiligo.
- Author
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Oguz Topal I, Duman H, Gungor S, Kocaturk E, and Kuteyla Can P
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Cohort Studies, Female, Humans, Male, Middle Aged, Socioeconomic Factors, Turkey, Vitiligo complications, Young Adult, Vitiligo epidemiology, Vitiligo psychology
- Abstract
Vitiligo is an acquired, pigmentary skin disorder that affects about 0.1-4.0% of the population. In this study, we aimed to investigate the disease features such as age of onset, disease duration, clinical and sociodemographic characteristics, and laboratory parameters of patients with vitiligo. A hundred patients who were in follow-up for vitiligo between the period of June 2013 and May 2014 were included in the study. The clinical features and laboratory parameters were retrospectively obtained from the records of the patients. The mean age was 34.9±16.8 years. The most common clinical types were focal and acrofacial. Facial involvement was the most common localization. Forty-five (45%) patients had an associated systemic disease. Autoimmune thyroid disease, essential hypertension, and alopecia areata, which were observed in 28%, 8%, and 5% of patients, respectively, were the most common associated diseases. Twenty-one percent of the patients had low ferritin levels, 20% had low iron levels, 12% had low vitamin B12 levels, and 1% had low folic acid levels. The prevalence of anti-TG (anti-thyroglobulin) and anti-TPO (anti-thyroid peroxidase) antibodies were found 17% and 27% of the patients, respectively. We found that the clinical characteristics of vitiligo in our patients were similar to those in other studies. We observed laboratory abnormalities and accompanying diseases associated with vitiligo. Therefore we conclude that laboratory examinations including thyroid antibodies and regular follow-up of these patients are essential.
- Published
- 2016
46. Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria?
- Author
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Oguz Topal I, Kocaturk E, Gungor S, Durmuscan M, Sucu V, and Yıldırmak S
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Chronic Disease, Dietary Supplements, Female, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Vitamin D analogs & derivatives, Vitamin D blood, Vitamin D Deficiency complications, Vitamins therapeutic use, Young Adult, Cholecalciferol administration & dosage, Quality of Life, Urticaria drug therapy, Vitamin D Deficiency drug therapy
- Abstract
Background: Vitamin D plays a key role in the immune responses generated by lymphocytes and antigen-presenting cells. Decreased vitamin 25-hydroxyvitamin D (25(OH)D) levels have been implicated in several allergic disorders and association between 25(OH)D levels and chronic urticaria (CU) symptom scores has been evaluated in a few studies. This study was performed to assess the effects of vitamin D supplementation on the symptoms and quality of life scores in chronic spontaneous urticaria (CSU) and to vitamin D levels in CSU patients in comparison with controls., Patients and Methods: Fifty-eight CSU patients and forty-five controls were included in the study. The patients were divided into two groups according to severity of the disease; as mild/moderate and severe urticaria. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured in serum of CSU patients and compared with the control groups. In patients with 25(OH)D concentrations lower than 30 µg/L, 300 000 IU/month of vitamin D3 supplementation was added to standard therapy. The clinical improvement was evaluated after 3 months with urticaria activity score (UAS4) and Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL)., Results: Serum 25(OH)D concentration was significantly lower in CSU group compared to healthy subjects (p < 0.001). The prevalence of vitamin D deficiency (<20 (µg/L) and insufficiency (<30 µg/L) was significantly higher in CSU patients than control groups. In addition, 25(OH)D concentrations were significantly lower in both mild-moderate and severe CSU patients than those of the controls (p = 0.011 and p < 0.001, respectively). Ninety eight percent of patients (25(OH)D < 30 µg/L) were treated with vitamin D3 (300 000 IU/month) supplementation, and after 12 weeks, these patients showed significant improvements in UAS4 and CU-Q2oL scores., Conclusion: This study support the contributing and beneficial effects of vitamin D in the treatment of CU. Replacement of vitamin D may provide improvement in both the severity of symptoms and the quality of life scores in these patients.
- Published
- 2016
- Full Text
- View/download PDF
47. Pediatric Dermatology Photoquiz: Refractory Purulent Paronychia in a Young Girl. Paronychial cutaneous leishmaniasis.
- Author
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Oguz Topal I, Duman H, Baz V, Gungor S, Kocaturk E, and Özekinci S
- Subjects
- Antiprotozoal Agents therapeutic use, Child, Female, Humans, Leishmaniasis, Cutaneous complications, Leishmaniasis, Cutaneous drug therapy, Meglumine therapeutic use, Meglumine Antimoniate, Nails pathology, Organometallic Compounds therapeutic use, Paronychia drug therapy, Leishmaniasis, Cutaneous diagnosis, Paronychia diagnosis
- Published
- 2016
- Full Text
- View/download PDF
48. Successful treatment of a bullous urticaria with omalizumab.
- Author
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Ozturk AB, Kocaturk E, and Ozturk E
- Subjects
- Adrenal Cortex Hormones administration & dosage, Aged, Drug Resistance, Eosinophils immunology, Humans, Immunoglobulin E blood, Immunoglobulin E immunology, Lymphocytes immunology, Male, Omalizumab, Recurrence, Anti-Allergic Agents administration & dosage, Antibodies, Anti-Idiotypic administration & dosage, Antibodies, Monoclonal, Humanized administration & dosage, Skin immunology, Skin Diseases, Vesiculobullous drug therapy, Urticaria drug therapy
- Published
- 2014
- Full Text
- View/download PDF
49. Omalizumab in recurring larynx angioedema: a case report.
- Author
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Ozturk AB and Kocaturk E
- Abstract
Angioedema with swelling of larynx is a serious allergic reaction and can be life-threatening. It can occur after exposure to various triggers and usually it is very difficult for the patient and the doctor to find the trigger and maintain complete remission. In idiopathic recurring angioedema presenting with frequent attacks, prophylaxis with H1 antihistamines recommended. However, not all patients respond to antihistamines. Omalizumab is an anti-immunoglobulin (Ig)-E-Ig-G antibody approved for the treatment of asthma and also effective treatment in chronic spontaneous urticaria. We report a 47-year-old male patient with severe idiopathic angioedema controlled by corticosteroid and proggressed after discontining of corticosteroid because of its side effects. Omalizumab at a dose of 300 mg every 4 weeks was administrated and omalizumab provided a rapid clinical response after first injection. During the 4 months of omalizumab therapy, he had no further attacks and any other treatment needs. After 3 months of stopping omalizumab therapy, during the 4-week period he had two mild lip swelling in his lips that resolved with antihistamines.
- Published
- 2014
- Full Text
- View/download PDF
50. A neonate with a challenging diagnosis (discussion and diagnosis).
- Author
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Mungan Akin I, Ozumut SS, Kocaturk E, Zemheri IE, Buyukkayhan D, and Ozdemir O
- Subjects
- Acyclovir administration & dosage, Aminoglycosides administration & dosage, Ampicillin administration & dosage, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Antiviral Agents administration & dosage, Antiviral Agents therapeutic use, Biopsy, Diagnosis, Differential, Drug Therapy, Combination, France, Histiocytosis, Langerhans-Cell congenital, Humans, Infant, Newborn, Skin Diseases, Vesiculobullous drug therapy, Acyclovir therapeutic use, Aminoglycosides therapeutic use, Ampicillin therapeutic use, Histiocytosis, Langerhans-Cell diagnosis, Skin Diseases, Vesiculobullous diagnosis
- Published
- 2013
- Full Text
- View/download PDF
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