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Your search keyword '"Kocacan, Suleyman Emre"' showing total 25 results
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25 results on '"Kocacan, Suleyman Emre"'

1. Effect of minocycline on total oxidant-antioxidant levels and penicillin induced epileptiform activity in rats.

Author

Tosun, Sinem, Kocacan, Suleyman Emre, Agar, Erdal, and Ayyildiz, Mustafa

Subjects
*OXIDANT status, *EPILEPTIFORM discharges, *REACTIVE oxygen species, *ANTICONVULSANTS, *FREE groups
Abstract

Involvement of minocycline in stages of infection, neuroprotection, and inflammation is well known. However, the effect of minocycline on various rat brain regions and plasma TAS (total antioxidant status), TOS (total oxidant status) values, and electrophysiology with penicillin-induced epileptiform activity have not been investigated. Here, we examined the electrophysiological effects of different minocycline doses in an experimental epilepsy model that started locally and became generalised. We compared the tissue and plasma TAS-TOS values of the antiepileptic dose of the drug with the control, sham, and drug free epileptic groups. Electrophysiological demonstrations revealed that minocycline has an anticonvulsant effect on penicillin induced epilepsy rats (P<0.05, 0.01 and 0.001) and its effective dose. With biochemical components of the study, it was found that minocycline had an antioxidant effect on serum and brain tissues of rats with penicillin induced epilepsy (P<0.05, 0.01). [ABSTRACT FROM AUTHOR]

Published
2024
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7. Effect of Nesfatin-1 on Oxidative Stress Parameters in Experimental Epilepsy Model

Author

Keloglan, Seval, Yazgan, Burak, Sen, Fatma Banu, Kocacan, Suleyman Emre, Mustafa AYYILDIZ, Agar, Erdal, and Ondokuz Mayıs Üniversitesi

Subjects
Neuropeptide, Oxidative stres, Nesfatin-1, Experimental epilepsy
Abstract

WOS: 000532415800192 … Amasya UniversityAmasya University [FMB-BAP 17-0288] This study was supported by Amasya University (Project number: FMB-BAP 17-0288).

Published
2019

8. The Role of NMDA Receptor Blocker Memamtine in the Effect of P2X7 Receptors on Penicillininduced Epileptiform Activity

Author

Arslan, Gokhan, Kocacan, Suleyman Emre, Mustafa AYYILDIZ, Rzayev, Emil, Avci, Bahattin, Agar, Erdal, Ondokuz Mayıs Üniversitesi, and [Arslan, Gokhan] Cumhuriyet Univ, Dept Physiol, Fac Med, Sivas, Turkey -- [Kocacan, Suleyman Emre -- Ayyildiz, Mustafa -- Agar, Erdal] Ondokuz Mayis Univ, Dept Physiol, Fac Med, Samsun, Turkey -- [Rzayev, Emil -- Avci, Bahattin] Ondokuz Mayis Univ, Dept Biochem, Fac Med, Samsun, Turkey

Abstract

WOS: 000419806200195, …

Published
2017

9. The Effect Of P2X7 Receptors On Penicillin-Induced Epileptiform Activity And The Role Of T-Type Calcium Channel Inhibitor Nnc 55-3069 On This Effect

Author

Arslan, Gokhan, Kocacan, Suleyman Emre, Mustafa AYYILDIZ, Rzayev, Emil, Avci, Bahattin, Agar, Erdal, Ondokuz Mayıs Üniversitesi, and [Arslan, Gokhan] Cumhuriyet Univ, Fac Med, Dept Physiol, Sivas, Turkey -- [Kocacan, Suleyman Emre -- Ayyildiz, Mustafa -- Agar, Erdal] Ondokuz Mayis Univ, Fac Med, Dept Physiol, Samsun, Turkey -- [Rzayev, Emil -- Avci, Bahattin] Ondokuz Mayis Univ, Fac Med, Dept Med Biochem, Samsun, Turkey

Abstract

WOS: 000419806200045, …, TUBITAK [115S361], This study is supported by TUBITAK (Project number: 115S361)

Published
2017

15. Seizures with Pentylenetetrazoll indling Cause a Decrease in the Number of Pyramidal Neurons in the Rat Hippocampus

Author

Kocacan, Suleyman Emre, Sefil, Fatih, Elibol, Ebru, Altunkaynak, Berrin Z., Acar, Meryem Dilek, Bagirici, Faruk, Kaplan, Süleyman, and Ondokuz Mayıs Üniversitesi

Subjects
nervous system, convulsants, pentylenetetrazole, kindling, neurologic, neurological disorders, neurotoxicity, stereology, food and beverages, epilepsy, neurotoxicity syndromes, neurotoxin diseases, seizures
Abstract

Kaplan, Suleyman/0000-0003-1477-5002 WOS: 000387093200007 OBJECTIVE: To investigate the effects of pentylenetetra-zole (PTZ) kindling on the number of pyramidal neurons in the rat hippocampus. STUDY DESIGN: Using unbiased stereology, we calculated total pyramidal neuron numbers in the CA1, CA2, and CA3 areas and the whole hippocampus after PTZ-induced kindling. The estimation and the analysis of the number of hippocampal pyramidal cells (areas of CA1-3) were done with the optical fractionator technique, which is a stereological counting technique. RESULTS: Stereological analysis showed that the total number of pyramidal neurons in the whole hippocampus and the number of pyramidal neurons in CA1 were significantly lower in kindled rats as compared to the controls (p0.05). CONCLUSION: PTZ-induced seizures cause a decrease in the amount of pyramidal neurons in the CA area of the rat hippocampus.

Published
2016

19. The Effect of P2X7 Receptor Antagonist A-438079 on Penicillin-induced Epileptiform Activity

Author

Arslan, Gokhan, Kocacan, Suleyman Emre, Mustafa AYYILDIZ, Rzayev, Emil, Avci, Bahattin, Agar, Erdal, Ondokuz Mayıs Üniversitesi, [Arslan, Gokhan] Cumhuriyet Univ, Dept Physiol, Fac Med, Sivas, Turkey -- [Kocacan, Suleyman Emre -- Ayyildiz, Mustafa -- Agar, Erdal] Ondokuz Mayis Univ, Dept Physiol, Fac Med, Samsun, Turkey -- [Rzayev, Emil -- Avci, Bahattin] Ondokuz Mayis Univ, Dept Med Biochem, Fac Med, Samsun, Turkey, Arslan, Gokhan -- 0000-0003-4186-2478, and AVCI, Bahattin -- 0000-0001-6471-6495

Abstract

WOS: 000383578300203, …

25. Postlaminectomy Bone and Scar Formations in Presence of Ankaferd Blood Stopper and Bitter Melon (Momordica Charantia): An Experimental Study.

Author

Kuruoglu E, Onger ME, Marangoz AH, Kocacan SE, Cokluk C, and Kaplan S

Subjects
Animals, Cicatrix pathology, Fibrosis drug therapy, Fibrosis pathology, Laminectomy trends, Lumbar Vertebrae surgery, Male, Osteogenesis physiology, Plant Extracts pharmacology, Postoperative Complications drug therapy, Postoperative Complications pathology, Random Allocation, Rats, Rats, Wistar, Cicatrix drug therapy, Laminectomy adverse effects, Momordica charantia, Osteogenesis drug effects, Plant Extracts therapeutic use
Abstract

Aim: A quantitative model of postlaminectomy was designed in rats. The effects of Momordica Charantia (MC) and Ankaferd blood stopper (ABS) on the bone and scar formation after laminectomy were concurrently evaluated., Material and Methods: Eighteen adult Wistar albino rats underwent lumbar laminectomy at L2-L3 vertebral levels, and were randomly assigned to one of three groups of six rats each. The Treatment group received MC and ABS treatment and the Control group was left untreated. Rats were sacrificed 4 weeks after treatment. Then; the lumbar spine was excised en-block, fixed and decalcified. Sections were stained with hematoxylin and eosin (H&E) and Masson"s trichrome, and evaluated for peridural fibrosis (PF), new bone formation, and vascular proliferation., Results: Total volume of new bone in the MC group was significantly increased in comparison to the Control group (p < 0.05). Also; there was highly significant increase in terms of the total volume of fibrous tissue in the MC and ABS groups when compared with the Control group (p < 0.01). Besides; there was a highly significant difference between the MC and the Control groups (p < 0.01) in point of total volume of vessel., Conclusion: Both MC and ABS are not convenient to prevent the PF formation and MC may promote new bone formation and angiogenesis after lumbar laminectomy in rats.

Published
2017
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