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12. Morphological and Tissue Alterations in one Papillary Muscle: an Early Sign of Hypertrophic Cardiomyopathy?

Author

Cresti, A., giovanni donato aquaro, Picotti, A., Kocabay, G., and Todiere, G.

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:RC666-701, Hypertrophic Cardiomyopathy, cardiovascular diseases, Papillary Muscles
Abstract

Isolated Papillary Muscle (PM) hypertrophy has been supposed to be a phenotypic variant of hypertrophic cardiomyopathy. Whether this finding may explain an electrocardiographic pattern of left ventricular hypertrophy has to be demonstrated. A cardiac magnetic resonance imaging may add additional crucial information. Our case was a 26-year-old asymptomatic male cyclist who underwent routine sport medicine screening. His cousin had suddenly died during a bicycle race at 40 years of age, and autopsy had revealed a hypertrophic cardiomyopathy. Screening revealed an electrocardiographic pattern of left ventricular hypertrophy. A multimodal imaging examination was also performed and the only abnormal finding was a hypertrophic anterolateral PM and cardiac magnetic resonance imaging showed fibrotic substitution of its head. An otherwise unexplained electrocardiographic pattern of left ventricular hypertrophy can be justified by an isolated PM hypertrophy. Cardiac magnetic resonance imaging is crucial for precise ventricular wall and papillary thickness measurement. In the presence of an isolated PM hypertrophy, postgadolinium T1 mapping can demonstrate the presence of abnormal tissue and probably fibrosis of the papillary head, which can confirm the presence of a strictly localized form of hypertrophic cardiomyopathy.

Published
2016

13. Novel three-dimensional transoesophageal echocardiography platform allows a fast and accurate assessment of aortic annulus size and shape before transcatheter aortic valve implantation

Author

Muraru, D, Napodano, M, Badano, L, Tarantini, G, Sarais, C, Kocabay, G, Isabella, G, D’Onofrio, A, Gerosa, G, Iliceto, S, Muraru Denisa, Napodano Massimo, Badano Luigi, Tarantini Giuseppe, Sarais Cristiano, Kocabay G, Isabella G, D’Onofrio A, Gerosa G, Iliceto S, Muraru, D, Napodano, M, Badano, L, Tarantini, G, Sarais, C, Kocabay, G, Isabella, G, D’Onofrio, A, Gerosa, G, Iliceto, S, Muraru Denisa, Napodano Massimo, Badano Luigi, Tarantini Giuseppe, Sarais Cristiano, Kocabay G, Isabella G, D’Onofrio A, Gerosa G, and Iliceto S

Abstract

Background: In TAVI procedures, accurate sizing of aortic annulus (AA) is paramount to avoid complications. Novel 3D transoesophageal echo (3DTOE) platform enables direct measurements on volume-rendered 3D datasets, speeding up AA sizing in the cath lab. Our aim was to validate AA measurements by novel 3DTOE against computerized tomography (CT). Methods: Minimum (Min) and maximum (Max) AA diameters, and their ratio (ellipticity index, EI) were obtained in 12 consecutive patients (9 men, aged 84 ± 4 y) who underwent pre-TAVI 2D and 3DTOE (Vivid E9 with 6VT-D probe, GE Ultrasound, N) and CT scan less than 1 week apart. Results: AA sizing required 58 ± 20 sec on 3D volume-rendered datasets and 95 ± 17 sec on multislice (MS) views (p < 0.003) (Figure). At CT, Max was 25.4 ± 2 mm, Min was 21.6 ± 2.1 mm, and EI was 1.2 ± 0.07. Accuracy of 3DTOE is reported in Table. Conventional 2D antero-posterior diameters underestimated Max in comparison to both 3D volume-rendered and MS (bias=-2.8 mm and -2.9 mm, respectively). Conclusions: AA sizing can be performed in a fast and reliable way using novel 3DTOE. Direct measurement on 3D volume-rendered seems as accurate as measuring on MS views, but significantly less time-consuming.

Published
2012

14. Two-dimensional assessment of tricuspid annulus dynamics and diameters: study for new reference values

Author

Miglioranza, MH, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, Naso, P, Puma, L, Kocabay, G, Iliceto, S, Badano, L, Miglioranza, M, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, Naso, P, Puma, L, Kocabay, G, Iliceto, S, and Badano, L

Abstract

Background: Tricuspid annulus (TA) size and function plays an important role in decision-making process about the need of associated TA annuloplasty during left sided cardiac surgery. Recommendations about echo assessment of TA don't indicate the view and the timing where TA should be measured. Our aim was to study TA diameters and shortening in different 2D TTE views to assess the extent of their variability. Methods: Cross-sectional study of normal volunteers. TA was measured from 3 2DTTE views (apical 4-CH, LAX-RV inflow, SAX basal) at 5 time points during cardiac cycle. TA fractional shortening diameter was obtained as (TV opening early-filling – Mid-systole) / TV opening early-filling. Result: 100pts; 42%male; 44±13yrs. TA diameters are in the Table. Fractional shortening of TA was 22±7%, 18±8%, 31±16% in 4-CH, LAX-RV inflow and SAX basal views respectively. Conclusion: This study support new references values for TA evaluation using 2D TTE. Values vary according to 2D TTE view and cardiac cycle time, showing the dynamism and complex geometry of TA

Published
2013

15. Novel three-dimensional transoesophageal echocardiography platform allows a fast and accurate assessment of aortic annulus size and shape before transcatheter aortic valve implantation

Author

Muraru Denisa, Napodano Massimo, Badano Luigi, Tarantini Giuseppe, Sarais Cristiano, Kocabay G, Isabella G, D’Onofrio A, Gerosa G, Iliceto S, Muraru, D, Napodano, M, Badano, L, Tarantini, G, Sarais, C, Kocabay, G, Isabella, G, D’Onofrio, A, Gerosa, G, and Iliceto, S

Subjects
three-dimensional echocardiography, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
Abstract

Background: In TAVI procedures, accurate sizing of aortic annulus (AA) is paramount to avoid complications. Novel 3D transoesophageal echo (3DTOE) platform enables direct measurements on volume-rendered 3D datasets, speeding up AA sizing in the cath lab. Our aim was to validate AA measurements by novel 3DTOE against computerized tomography (CT). Methods: Minimum (Min) and maximum (Max) AA diameters, and their ratio (ellipticity index, EI) were obtained in 12 consecutive patients (9 men, aged 84 ± 4 y) who underwent pre-TAVI 2D and 3DTOE (Vivid E9 with 6VT-D probe, GE Ultrasound, N) and CT scan less than 1 week apart. Results: AA sizing required 58 ± 20 sec on 3D volume-rendered datasets and 95 ± 17 sec on multislice (MS) views (p < 0.003) (Figure). At CT, Max was 25.4 ± 2 mm, Min was 21.6 ± 2.1 mm, and EI was 1.2 ± 0.07. Accuracy of 3DTOE is reported in Table. Conventional 2D antero-posterior diameters underestimated Max in comparison to both 3D volume-rendered and MS (bias=-2.8 mm and -2.9 mm, respectively). Conclusions: AA sizing can be performed in a fast and reliable way using novel 3DTOE. Direct measurement on 3D volume-rendered seems as accurate as measuring on MS views, but significantly less time-consuming.

Published
2012

16. Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: A two- and three-dimensional echocardiographic study

Author

Tadic, M, Celic, V, Cuspidi, C, Ilic, S, Pencic, B, Radojkovic, J, Ivanovic, B, Stanisavljevic, D, Kocabay, G, Marjanovic, T, CUSPIDI, CESARE, Marjanovic, T., Tadic, M, Celic, V, Cuspidi, C, Ilic, S, Pencic, B, Radojkovic, J, Ivanovic, B, Stanisavljevic, D, Kocabay, G, Marjanovic, T, CUSPIDI, CESARE, and Marjanovic, T.

Abstract

Background: The aim of this study was to determine right ventricular (RV) and right atrial (RA) deformation assessed by two-dimensional echocardiographic and three-dimensional echocardiographic (3DE) imaging in patients with prediabetes and type 2 diabetes mellitus. Methods: This cross-sectional study included 47 untreated normotensive subjects with prediabetes, 57 recently diagnosed normotensive patients with diabetes, and 54 healthy controls of similar sex and age distributions. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. Results: Three-dimensional echocardiographic RV end-diastolic volume index gradually decreased from controls across patients with diabetes to those with diabetes (69 ± 10 vs 63 ± 8 vs 58 ± 8mL/m2, P < .001), whereas 3DE RV end-systolic volume index was higher in controls compared with patients with diabetes and those with diabetes (25 ± 4 vs 23 ± 4vs 22 ± 4mL/m2, P < .001). However, there was no difference in 3DE RV ejection fraction among the three groups (63 ± 4% vs 62 ± 4% vs 61 ± 5%, P = .063). RV and RA global strain and systolic and early diastolic strain rates were decreased in patients with prediabetes and in those with diabetes compared with controls, whereas RV and RA late diastolic strain rates were increased in these patients. Multivariate regression analysis showed that RV global strain was associated with glycated hemoglobin, independent of left ventricular parameters. Conclusions: RV and RA myocardial deformation and function obtained by 3DE and two-dimensional echocardiographic strain, even in normal ranges, were decreased in patients with prediabetes and in those with diabetes compared with controls. The long-term parameter of glucose control was correlated with the right heart mechanics.

Published
2015

18. Alkaline phosphatase: can it be considered as an indicator of liver fibrosis in non-alcoholic steatohepatitis with type 2 diabetes?

Author

Kocabay, G., Telci, A., YILDIZ TÜTÜNCÜ, Tiryaki, B., Ozel, S., Cevikbas, U., Okten, A., and Satman, I.

Subjects
Fatty Liver, Liver Cirrhosis, Male, Diabetes Mellitus, Type 2, Liver, Non-alcoholic Fatty Liver Disease, Biopsy, Needle, Humans, Female, Middle Aged, Alkaline Phosphatase, Biomarkers
Abstract

While isolated hepatosteatosis is a benign disease, in minority of cases non-alcoholic steatohepatitis (NASH) may even lead to cirrhosis in long-term. In order to find the stage of the disease and determine the prognosis, a liver biopsy is indicated. In this study, we studied the relationship of liver histopathological findings with serum levels of hepatic enzymes.We recruited 52 cases of NASH with Type 2 diabetes mellitus. Diagnosis of NASH was made based on biochemical tests, ultrasound images and liver biopsy.Steatosis was mild in 57.7%, moderate in 30.8%, and severe in 11.6% of patients. While no infiltration was found in 78.8% of cases, there was a grade-1 infiltration in 15.4% and a grade-2 infiltration in 5.8% of cases. Similarly, no fibrosis was found in 42.3% of patients, but there was a stage-1 fibrosis in 50%, and a stage-2 fibrosis in 7.7% of cases. In patients with severe steatosis, serum levels of AST were higher than mild or moderate stage steatosis. Accordingly, in patients with no inflammation, serum levels of ALT were higher than in patients with inflammation. However, in patients with fibrosis, triglycerides levels were significantly lower and ALP was significantly higher than in patients without fibrosis. The correlation analysis indicated a positive association between serum levels of ALP and C-peptide.In addition to conventional risk factors such as age, presence of diabetes, female sex; higher levels of ALP may be considered as a risk factor linked to hepatic fibrosis in patients with NASH and type 2 diabetes (Tab. 6, Ref. 8).

Published
2011

19. Normal left ventricular mechanics by two-dimensional speckle-tracking echocardiography. Reference values in healthy adults

Author

Kocabay, G, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, PADAYATTIL JOSE, S, Denas, G, Iliceto, S, Vinereanu, D, Badano, L, Kocabay, Gonenc, MURARU, DENISA, PELUSO, DILETTA MARIA, CUCCHINI, UMBERTO, Mihaila, Sorina, PADAYATTIL JOSE, SEENA, DENAS, GENTIAN, ILICETO, SABINO, Vinereanu, Dragos, BADANO, LUIGI, Kocabay, G, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, PADAYATTIL JOSE, S, Denas, G, Iliceto, S, Vinereanu, D, Badano, L, Kocabay, Gonenc, MURARU, DENISA, PELUSO, DILETTA MARIA, CUCCHINI, UMBERTO, Mihaila, Sorina, PADAYATTIL JOSE, SEENA, DENAS, GENTIAN, ILICETO, SABINO, Vinereanu, Dragos, and BADANO, LUIGI

Abstract

Introduction and objectives Two-dimensional speckle-tracking echocardiography is a novel tool to assess myocardial function. The purpose of this study was to evaluate left ventricular myocardial strain and rotation parameters by two-dimensional speckle-tracking echocardiography in a large group of healthy adults across a wide age range to establish their reference values and to assess the influence of age, sex, and hemodynamic factors. Methods Transthoracic echocardiograms were acquired in 247 healthy volunteers (139 women, 44 years [standard deviation, 16 years old] (range, 18-80 years). We measured longitudinal, circumferential, and radial peak systolic strain values, and left ventricular rotation and twist. Results Average values of global longitudinal, radial, and circumferential strain were -21.5% (standard deviation, 2.0%), 40.1% (standard deviation, 11.8%) and -22.2% (standard deviation, 3.4%), respectively. Longitudinal strain was significantly more negative in women, whereas radial and circumferential strain and rotational parameters were similar in both sexes. Accordingly, lower limits of normality for the strain components were -16.9% in men and -18.5% in women for longitudinal strain, and -15.4% for circumferential and 24.6% for radial strain, irrespective of sex. Longitudinal strain values were more negative at the base than at apical segments. Mean rotational values were -6.9 ° (standard deviation, 3.5 °) for the base, 13.0 ° (standard deviation, 6.5 °) for apical rotation, and 20.0 ° (standard deviation, 7.3 °) for net twist. Conclusions We report the comprehensive assessment of normal myocardial deformation and rotational mechanics in a large cohort of healthy volunteers. We found that women have more negative longitudinal strain, accounting for their higher left ventricular ejection fraction. Availability of reference values for these parameters may foster their implementation in the clinical routine. Full English text available from: www.revespcard

Published
2014

20. Ascending aorta diameters measured by echocardiography using both leading edge-to-leading edge and inner edge-to-inner edge conventions in healthy volunteers

Author

Muraru, D, Maffessanti, F, Kocabay, G, Peluso, D, Bianco Lucia, D, Piasentini, E, Jose Seena, P, Iliceto, S, Badano, L, Muraru Denisa, Maffessanti Francesco, Kocabay Gonenc, Peluso Diletta, Bianco Lucia Dal, Piasentini Eleonora, Jose Seena Padayattil, Iliceto Sabino, Badano Luigi, Muraru, D, Maffessanti, F, Kocabay, G, Peluso, D, Bianco Lucia, D, Piasentini, E, Jose Seena, P, Iliceto, S, Badano, L, Muraru Denisa, Maffessanti Francesco, Kocabay Gonenc, Peluso Diletta, Bianco Lucia Dal, Piasentini Eleonora, Jose Seena Padayattil, Iliceto Sabino, and Badano Luigi

Abstract

AIMS: Reference ranges of ascending aorta diameters (AAoD) for two-dimensional echocardiography (2DE) using inner edge (IE) convention are lacking, preventing the comparison of AAoD measurements by 2DE with those obtained by other imaging modalities. METHODS AND RESULTS: We used harmonic imaging 2DE to prospectively study 218 healthy volunteers (56% women, 42 ± 15 years, 18-80 years). Measurements were performed at the level of aortic root (AoR), sinotubular junction (STJ), and proximal tubular portion (TAo, 1 cm from the STJ) using both leading edge (LE) and IE conventions at end-diastole and end-systole. Feasibility of AAoD measurements between end-diastole and end-systole was similar at AoR and STJ levels, but it was significantly different at TAo level (82 vs. 96%, respectively, P < 0.0001). Ascending aorta diameters indexed to height were larger in men than in women (P < 0.0001). After adjusting for the effect of gender, only age and body surface area (BSA) were independent predictors of AAoD at multivariable analysis. Average end-diastolic AoR, STJ, and TAo diameters measured using IE convention were similar between genders (17 ± 2, 15 ± 2, and 15 ± 2 mm/m(2), respectively). Corresponding AAoD measured using the LE convention were 18 ± 2, 16 ± 2, and 17 ± 4 mm/m(2), respectively. On average, the end-systolic AAoD measured using LE were 2 mm larger than those performed using IE or at end-diastole. Mean aortic wall thickness was 2.4 ± 0.8 mm. CONCLUSION: End-diastolic AAoD measured using IE were significantly smaller than those obtained either using LE convention or at end-systole. Gender-specific reference values for AAoD indexed for BSA should be used to identify ascending aorta pathology.

Published
2014

22. Two-dimensional assessment of tricuspid annulus dynamics and diameters: study for new reference values

Author

Miglioranza, M, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, Naso, P, Puma, L, Kocabay, G, Iliceto, S, Badano, L, Miglioranza, MH, Miglioranza, M, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, Naso, P, Puma, L, Kocabay, G, Iliceto, S, Badano, L, and Miglioranza, MH

Abstract

Background: Tricuspid annulus (TA) size and function plays an important role in decision-making process about the need of associated TA annuloplasty during left sided cardiac surgery. Recommendations about echo assessment of TA don't indicate the view and the timing where TA should be measured. Our aim was to study TA diameters and shortening in different 2D TTE views to assess the extent of their variability. Methods: Cross-sectional study of normal volunteers. TA was measured from 3 2DTTE views (apical 4-CH, LAX-RV inflow, SAX basal) at 5 time points during cardiac cycle. TA fractional shortening diameter was obtained as (TV opening early-filling – Mid-systole) / TV opening early-filling. Result: 100pts; 42%male; 44±13yrs. TA diameters are in the Table. Fractional shortening of TA was 22±7%, 18±8%, 31±16% in 4-CH, LAX-RV inflow and SAX basal views respectively. Conclusion: This study support new references values for TA evaluation using 2D TTE. Values vary according to 2D TTE view and cardiac cycle time, showing the dynamism and complex geometry of TA

Published
2013

23. Diastolic mitral regurgitation in 2:1 atrioventricular block: Insight of the diastolic pressure

Author

Kocabay, G, Peluso, D, Muraru, D, Iliceto, S, Badano, L, Kocabay, Gonenc, Peluso, Diletta, Muraru, Denisa, Iliceto, Sabino, Badano, Luigi, Kocabay, G, Peluso, D, Muraru, D, Iliceto, S, Badano, L, Kocabay, Gonenc, Peluso, Diletta, Muraru, Denisa, Iliceto, Sabino, and Badano, Luigi

Abstract

Mini-Abstract We present a 74-year-old man with a history of hypertension presented to the emergency room with shortness of breath and dizziness. A resting electrocardiogram showed 2:1 atrioventricular block with a wide QRS duration and a rhythm of 35 beats/min. Transthoracic echocardiography was performed and color flow Doppler, color M-mode, and continuous-wave Doppler recordings of the transmitral flow revealed retrograde flow into the left atrium after the blocked P-wave, which indicate holodiastolic mitral regurgitation.

Published
2013

24. Right atrial size and function assessed with three-dimensional and speckle-tracking echocardiography in 200 healthy volunteers

Author

Peluso, D, Badano, L, Muraru, D, DAL BIANCO, L, Cucchini, U, Kocabay, G, Kovàcs, A, Casablanca, S, Iliceto, S, PELUSO, DILETTA MARIA, BADANO, LUIGI, MURARU, DENISA, DAL BIANCO, LUCIA, CUCCHINI, UMBERTO, Kocabay, Gonenc, Kovàcs, Attila, Casablanca, Simona, ILICETO, SABINO, Peluso, D, Badano, L, Muraru, D, DAL BIANCO, L, Cucchini, U, Kocabay, G, Kovàcs, A, Casablanca, S, Iliceto, S, PELUSO, DILETTA MARIA, BADANO, LUIGI, MURARU, DENISA, DAL BIANCO, LUCIA, CUCCHINI, UMBERTO, Kocabay, Gonenc, Kovàcs, Attila, Casablanca, Simona, and ILICETO, SABINO

Abstract

AIMS: Right atrial (RA) size predicts the outcome in some pathological conditions but reference values for RA volumes and myocardial function remain to be defined. Thus, we used two-dimensional speckle-tracking echocardiography (2D-STE) and three-dimensional echocardiography (3DE) to define normative reference values of RA volumes and function. METHODS AND RESULTS: Two hundreds healthy volunteers (43 ± 15 years, range 18-75; 44% men) underwent two-dimensional echocardiography (2DE) to obtain RA volumes and longitudinal strain (LS) of RA wall using 2D-STE, and 3DE to measure maximal (Vmax), minimal, and preA volumes to calculate total, passive, and active emptying volumes (TotEV, PassEV, and ActEV) and emptying fractions (TotEF, PassEF, and ActEF). Three-dimensional echocardiography volumes (Vmax, 52 ± 15 mL vs. 41 ± 14 mL), EVs (TotEV, 33 ± 10 mL vs. 24 ± 9 mL), and EFs (TotEF, 63 ± 9 vs. 58 ± 9%) were larger than 2DE ones (all P < 0.0001). Indexed 3D volumes were significantly larger in men than in women. RA TotEF correlated with total LS (r = 0.24, P = 0.025) and PassEF with positive LS (LSpos; r = 0.34, P < 0.0001). Ageing was associated with a decrease in passive (LSpos, r = -041; PassEV, r = -0.26; PassEF, r = -0.38; all P < 0.0001) and an increase in active RA function (negative LS, r = 0.34; ActEV, r = 0.25; all P < 0.0001; and ActEF, r = 0.15; P = 0.035) in order to maintain TotEV (r = -0.14, P = 0.05). CONCLUSION:Our study provides normative values for RA volumes and function measured by 3DE and 2D-STE in a relatively large cohort of healthy subjects with a wide age range. These data will help clinicians to identify RA remodelling and dysfunction.

Published
2013

25. Comprehensive analysis of left ventricular geometry and function by three-dimensional echocardiography in healthy adults

Author

Muraru, D, Badano, L, Peluso, D, DAL BIANCO, L, Casablanca, S, Kocabay, G, Zoppellaro, G, Iliceto, S, MURARU, DENISA, BADANO, LUIGI, PELUSO, DILETTA MARIA, DAL BIANCO, LUCIA, Casablanca, Simona, Kocabay, Gonenc, ZOPPELLARO, GIACOMO, ILICETO, SABINO, Muraru, D, Badano, L, Peluso, D, DAL BIANCO, L, Casablanca, S, Kocabay, G, Zoppellaro, G, Iliceto, S, MURARU, DENISA, BADANO, LUIGI, PELUSO, DILETTA MARIA, DAL BIANCO, LUCIA, Casablanca, Simona, Kocabay, Gonenc, ZOPPELLARO, GIACOMO, and ILICETO, SABINO

Abstract

BACKGROUND: Recent European Association of Echocardiography and American Society of Echocardiography guidelines on three-dimensional echocardiography state that normal values of left ventricular (LV) parameters for age and body size remain to be established. METHODS: In 226 consecutive healthy subjects (125 women; age range, 18-76 years), comprehensive three-dimensional echocardiographic analyses of LV parameters were performed, and values were compared with those obtained by conventional echocardiography. RESULTS: Upper reference values (mean+ 2 SDs) for three-dimensional LV end-diastolic and end-systolic volumes were 85 and 34 mL/m(2) in men and 72 and 28 mL/m(2) in women, respectively. Indexing LV volumes to body surface area did not eliminate gender differences. Lower reference values (mean - 2 SDs) for ejection fraction were 54% in men and 57% in women and for stroke volume were 25 and 24 mL/m(2), respectively. Upper reference values for LV mass were 97 g/m(2) in men and 90 g/m(2) in women and for end-diastolic sphericity index were 0.49 and 0.48, respectively. Significant age dependency of LV parameters was identified and reported across age groups. Three-dimensional echocardiographic LV volumes were larger, ejection fraction was similar, and LV stroke volume and mass were significantly smaller in comparison with the corresponding values obtained by conventional echocardiography. CONCLUSIONS: The investigators report a comprehensive analysis of LV geometry and function using three-dimensional echocardiography in a relatively large cohort of healthy Caucasian subjects with a wide age range. These may serve to establish age-specific and gender-specific reference ranges, which are crucial for the routine implementation of three-dimensional echocardiography to detect LV remodeling and dysfunction in clinical practice.

Published
2013

27. Club 35 Moderated Poster Session - Part B: 11/12/2013, 09:30-16:00 * Location: Moderated Poster area

Author

Tuluce, K., primary, Yakar Tuluce, S., additional, Isayev, E., additional, Bilgin, M., additional, Yavuzgil, O., additional, Gurgun, C., additional, Nalbantgil, S., additional, Soydas Cinar, C., additional, Ozerkan, F., additional, Brandao Da Silva, D., additional, Lehmann, R., additional, Prinz, C., additional, Horstkotte, D., additional, Faber, L., additional, Assabiny, A., additional, Apor, A., additional, Nagy, A., additional, Vago, H., additional, Toth, A., additional, Merkely, B., additional, Kovacs, A., additional, Miglioranza, M., additional, Muraru, D., additional, Peluso, D., additional, Cucchini, U., additional, Mihaila, S., additional, Naso, P., additional, Puma, L., additional, Kocabay, G., additional, Iliceto, S., additional, Badano, L., additional, Marek, J., additional, Ahmed, M., additional, Ryo, K., additional, Haugaa, K., additional, Saba, S., additional, and Gorcsan, J., additional

Published
2013
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29. Reference values for aortic diameters obtained using both inner-­edge-­to-­inner-­edge and leading­-edge-­to-­leading-­edge methods in 190 healthy subjects

Author

Kocabay, G, Dal Bianco, L, Muraru, D, Peluso, D, Segafredo, B, Iliceto, S, Badano, L, Kocabay GK, Dal Bianco L, Muraru D, Peluso D, Segafredo B, Iliceto S, Badano L, Kocabay, G, Dal Bianco, L, Muraru, D, Peluso, D, Segafredo, B, Iliceto, S, Badano, L, Kocabay GK, Dal Bianco L, Muraru D, Peluso D, Segafredo B, Iliceto S, and Badano L

Abstract

ASE/EAE guidelines suggest to measure aortic diameters (AoD) using the leading edge-to-leading edge method (LEM), whereas ACC/AHA ones favor the inner edge-to-inner edge method (IEM) to increase reproducibility and consistency with MRI and CT. To obtain reference values of the AoD by transthoracic echocardiography using both LEM and IEM and to compare them, we prospectively studied 190 healthy volunteers (82 men, 44 + 14 years, range 18-80 years), using a Vivid E9 (GE Healthcare, Horten, Norway) with M5S probe and 2nd-harmonic imaging. On 2D images optimized for the aortic root and ascending aorta, a single observer performed offline measurements using LEM and IEM at the level of the aortic root (Ao-R), sino-tubular junction (STJ) and ascending aorta (AscAo, 1 cm from the STJ) at end-diastole (at R-wave on ECG). Reference AoD with both methods are reported in Table. As expected, at Bland-Altman’s analysis all AoD measured using LEM were significantly larger than those measured using IEM: Ao-R (bias= 3.1 mm; 95% LOA 0.9 – 5.3); STJ (bias=3.5 mm; 95% LOA 0.7 – 6.3), and AscAo (bias= 3.2 mm; 95% LOA 0.7 – 5.7). At multivariable regression analysis (including age, gender, body surface area (BSA), height, systolic blood pressure), age and BSA (adjusted R2= 0.42), were independent predictors of Ao-R diameters with both methods, while age, BSA and gender (adjusted R2 = 0.44) were independent predictors of AscAo diameter. Intra- and inter-observer variability was similar between LEM and IEM methods (2% vs 2%, p= 0.63, and 4% vs 5%, p=0.23 for AoR, respectively; and 3% vs 2%, p= 0.26, and 4% vs 6%, p= 0.15 for AscAo, respectively). This is the first report about reference values of the AoD obtained using both LEM and IEM, the difference in diameter measurement between the two methods, and the independent determinants of them in a largee population of healthy subjects.

Published
2012

35. Poster session Thursday 6 December - AM: Other myocardial diseases

Author

Ojaghi-Haghighi, Z., primary, Mostafavi, A., additional, Moladoust, H., additional, Noohi, F., additional, Maleki, M., additional, Esmaeilzadeh, M., additional, Samiei, N., additional, Hosseini, S., additional, Jasaityte, R., additional, Teske, A., additional, Claus, P., additional, Verheyden, B., additional, Rademakers, F., additional, D'hooge, J., additional, Patrianakos, A., additional, Zacharaki, A., additional, Kalogerakis, A., additional, Nyktari, E., additional, Maniatakis, P., additional, Parthenakis, F., additional, Vardas, P., additional, Hilde, J. M., additional, Skjoerten, I., additional, Humerfelt, S., additional, Hansteen, V., additional, Melsom, M., additional, Hisdal, J., additional, Steine, K., additional, Ippolito, R., additional, Gripari, P., additional, Muraru, D., additional, Esposito, R., additional, Kocabay, G., additional, Tamborini, G., additional, Galderisi, M., additional, Maffessanti, F., additional, Badano, L., additional, Pepi, M., additional, Yurdakul, S., additional, Oner, F., additional, Sahin, T., additional, Avci, B., additional, Tayyareci, Y., additional, Direskeneli, H., additional, Aytekin, S., additional, Filali, T., additional, Jedaida, B., additional, Lahidheb, D., additional, Gommidh, M., additional, Mahfoudhi, H., additional, Hajlaoui, N., additional, Dahmani, R., additional, Fehri, W., additional, Haouala, H., additional, Andova, V., additional, Georgievska-Ismail, L., additional, Srbinovska-Kostovska, E., additional, Gardinger, Y., additional, Joanna Hlebowicz, J., additional, Ola Bjorgell, O., additional, Magnus Dencker, M., additional, Liao, M.-T., additional, Tsai, C.-T., additional, Lin, J.-L., additional, Piestrzeniewicz, K., additional, Luczak, K., additional, Maciejewski, M., additional, Komorowski, J., additional, Jankiewicz-Wika, J., additional, Drozdz, J., additional, Ismail, M. F., additional, Alasfar, A., additional, Elassal, M., additional, El-Sayed, S., additional, Ibraheim, M., additional, Dobrowolski, P., additional, Klisiewicz, A., additional, Florczak, E., additional, Prejbisz, A., additional, Szwench, E., additional, Rybicka, J., additional, Januszewicz, A., additional, Hoffman, P., additional, Santos Furtado, M., additional, Nogueira, K., additional, Arruda, A., additional, Rodrigues, A. C., additional, Carvalho, F., additional, Silva, M., additional, Cardoso, A., additional, Lira-Filho, E., additional, Pinheiro, J., additional, Andrade, J. L., additional, Mohammed, M., additional, Zito, C., additional, Cusma-Piccione, M., additional, Di Bella, G., additional, Taha, N., additional, Zagari, D., additional, Oteri, A., additional, Quattrone, A., additional, Boretti, I., additional, Carerj, S., additional, Obremska, O., additional, Boratynska, B., additional, Poczatek, P., additional, Zon, Z., additional, Magott, M., additional, Klinger, K., additional, Szenczi, O., additional, Szelid, Z., additional, Soos, P., additional, Bagyura, Z., additional, Edes, E., additional, Jozan, P., additional, Merkely, B., additional, Ahn, J., additional, Kim, D., additional, Jeon, D., additional, Kim, I., additional, Baeza Garzon, F., additional, Delgado, M., additional, Mesa, D., additional, Ruiz, M., additional, De Lezo, J. S., additional, Pan, M., additional, Leon, C., additional, Castillo, F., additional, Morenate, M., additional, Toledano, F., additional, Zhong, L., additional, Lim, E., additional, Shanmugam, N., additional, Law, S., additional, Ong, B., additional, Katwadi, K., additional, Tan, R., additional, Chua, Y., additional, Liew, R., additional, Ding, Z., additional, Von Bibra, H., additional, Leclerque, C., additional, Schuster, T., additional, Schumm-Draeger, P.-M., additional, Bonios, M., additional, Kaladaridou, A., additional, Papadopoulou, O., additional, Tasoulis, A., additional, Pamboucas, C., additional, Ntalianis, A., additional, Nanas, J., additional, Toumanidis, S., additional, Silva, D., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Placido, R., additional, Jorge, C., additional, Calisto, C., additional, Robalo Martins, S., additional, Carvalho De Sousa, J., additional, Pinto, F., additional, Nunes Diogo, A., additional, Przewlocka-Kosmala, M., additional, Orda, A., additional, Karolko, B., additional, Mysiak, A., additional, Kosmala, W., additional, Moral Torres, S., additional, Rodriguez-Palomares, J., additional, Pineda, V., additional, Gruosso, D., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Figueras, J., additional, Cambronero, E., additional, Corbi, M. J., additional, Valle, A., additional, Cordoba, J., additional, Llanos, C., additional, Fernandez, M., additional, Lopez, I., additional, Hidalgo, V., additional, Barambio, M., additional, Jimenez, J., additional, D'andrea, A., additional, Riegler, L., additional, Cocchia, R., additional, Russo, M., additional, Bossone, E., additional, Calabro, R., additional, Iniesta Manjavacas, A., additional, Valbuena Lopez, S., additional, Lopez Fernandez, T., additional, Garcia-Blas, S., additional, De Torres Alba, F., additional, De Diego, J. G., additional, Ramirez Valdiris, U., additional, Mesa Garcia, J., additional, Moreno Yanguela, M., additional, Lopez-Sendon, J., additional, Logstrup, B., additional, Andersen, H., additional, Thuesen, L., additional, Christiansen, E., additional, Terp, K., additional, Klaaborg, K., additional, Poulsen, S., additional, Cacicedo, A., additional, Velasco, S., additional, Aguirre, U., additional, Onaindia, J., additional, Rodriguez, I., additional, Oria, G., additional, Subinas, A., additional, Zugazabeitia, G., additional, Romero, A., additional, Laraudogoitia Zaldumbide, E., additional, Weisz, S., additional, Magne, J., additional, Dulgheru, R., additional, Rosca, M., additional, Pierard, L., additional, Lancellotti, P., additional, Auffret, V., additional, Donal, E., additional, Bedossa, M., additional, Boulmier, D., additional, Laurent, M., additional, Verhoye, J., additional, Le Breton, H., additional, Van Hall, S., additional, Herbrand, T., additional, Ketterer, U., additional, Keymel, S., additional, Boering, Y., additional, Rassaf, T., additional, Meyer, C., additional, Zeus, T., additional, Kelm, M., additional, Balzer, J., additional, Floria, M., additional, Seldrum, S., additional, Mariciuc, M., additional, Laurence, G., additional, Buche, M., additional, Eucher, P., additional, Louagie, Y., additional, Jamart, J., additional, Marchandise, B., additional, Schroeder, E., additional, Venkatesh, A., additional, Sahlen, A., additional, Johnson, J., additional, Brodin, L., additional, Winter, R., additional, Shahgaldi, K., additional, Manouras, A., additional, Fusini, L., additional, Muratori, M., additional, Alamanni, F., additional, Bartorelli, A., additional, Ferrari, C., additional, Caiani, E., additional, Yaroslavskaya, E., additional, Kuznetsov, V., additional, Pushkarev, G., additional, Krinochkin, D., additional, Zyrianov, I., additional, Ciobotaru, C., additional, Kobayashi, Y., additional, Yamamoto, K., additional, Hirose, E., additional, Hirohata, A., additional, Ohe, T., additional, Jhund, P., additional, Cunningham, T., additional, Murday, V., additional, Findlay, I., additional, Sonecki, P., additional, Rangel, I., additional, Sousa, C., additional, Goncalves, A., additional, Correia, A., additional, Vigario, A., additional, Martins, E., additional, Silva-Cardoso, J., additional, Macedo, F., additional, Maciel, M., additional, Lovric, D., additional, Samardzic, J., additional, Milicic, D., additional, Reskovic, V., additional, Baricevic, Z., additional, Ivanac, I., additional, Separovic Hanzevacki, J., additional, Kim, K., additional, Song, J., additional, Jeong, H., additional, Yoon, H., additional, Ahn, Y., additional, Jeong, M., additional, Cho, J., additional, Park, J., additional, Kang, J., additional, Iorio, A., additional, Pinamonti, B., additional, Bobbo, M., additional, Merlo, M., additional, Barbati, G., additional, Massa, L., additional, Faganello, G., additional, Di Lenarda, A., additional, Sinagra, G., additional, Heggemann, F., additional, Hamm, K., additional, Streitner, F., additional, Sueselbeck, T., additional, Papavassiliu, T., additional, Borggrefe, M., additional, Haghi, D., additional, Ferreira, F., additional, Galrinho, A., additional, Soares, R., additional, Branco, L., additional, Abreu, J., additional, Feliciano, J., additional, Papoila, A., additional, Alves, M., additional, Leal, A., additional, Ferreira, R., additional, Reynaud, A., additional, Lund, L. H., additional, Oger, E., additional, Drouet, E., additional, Hage, C., additional, Bauer, F., additional, Linde, C., additional, Daubert, J., additional, Schnell, F., additional, Lentz, P., additional, Kervio, G., additional, Leurent, G., additional, Mabo, P., additional, Carre, F., additional, Rodrigues, A., additional, Roque, M., additional, Becker, D., additional, Barros, S., additional, Kay, F., additional, Emerick, T., additional, Sampaio-Barros, P., additional, Andrade, J., additional, Yamada, S., additional, Okada, K., additional, Iwano, H., additional, Nishino, H., additional, Nakabachi, M., additional, Yokoyama, S., additional, Kaga, S., additional, Mikami, T., additional, Tsutsui, H., additional, Mincu, R., additional, Magda, S., additional, Dumitrache Rujinski, S., additional, Constantinescu, T., additional, Mihaila, S., additional, Ciobanu, A., additional, Florescu, M., additional, Vinereanu, D., additional, Ashcheulova, T., additional, Kovalyova, O., additional, Ardeleanu, E., additional, Gurgus, D., additional, Gruici, A., additional, Suciu, R., additional, Ana, I., additional, Bergenzaun, L., additional, Ohlin, H., additional, Gudmundsson, P., additional, Willenheimer, R., additional, Chew, M., additional, Charalampopoulos, A., additional, Howard, L., additional, Davies, R., additional, Gin-Sing, W., additional, Tzoulaki, I., additional, Grapsa, I., additional, Gibbs, S., additional, Massabuau, P., additional, Weinert, L., additional, Lairez, O., additional, Berry, M., additional, Sotaquira, M., additional, Vaida, P., additional, Lang, R., additional, Khan, I., additional, Waterhouse, D., additional, Asegdom, S., additional, Alqaseer, M., additional, Foley, D., additional, Mcadam, B., additional, Colonna, P., additional, Michelotto, E., additional, Genco, W., additional, Rubino, M., additional, Pugliese, S., additional, Belfiore, A., additional, Sorino, M., additional, Trisorio Liuzzi, M., additional, Antonelli, G., additional, Palasciano, G., additional, Duszanska, A., additional, Skoczylas, I., additional, Streb, W., additional, Kukulski, T., additional, Polonski, L., additional, Kalarus, Z., additional, Fleig, A., additional, Seitz, K., additional, Secades, S., additional, Martin, M., additional, Corros, C., additional, Rodriguez, M., additional, De La Hera, J., additional, Garcia, A., additional, Velasco, E., additional, Fernandez, E., additional, Barriales, V., additional, Lambert, J., additional, Zwas, D. R., additional, Hoss, S., additional, Leibowitz, D., additional, Beeri, R., additional, Lotan, C., additional, Gilon, D., additional, Wierzbowska-Drabik, K., additional, Roszczyk, N., additional, Sobczak, M., additional, Plewka, M., additional, Chrzanowski, L., additional, Lipiec, P., additional, Kasprzak, J., additional, Wita, K., additional, Mizia-Stec, K., additional, Wrobel, W., additional, Plonska-Gosciniak, E., additional, Pinho, T., additional, Wang, Y., additional, Houle, H., additional, Madureira, A. J., additional, Zamorano, J., additional, Maciel, M. J., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Coppola, M., additional, Rapisarda, O., additional, Calabro', R., additional, Cadenas Chamorro, R., additional, Lopez, T., additional, Gomez, J., additional, Moreno, M., additional, Salinas, P., additional, Jimenez Rubio, C., additional, Valbuena, S., additional, Manjavacas, A., additional, De Torres, F., additional, Vaugrenard, T., additional, Huttin, O., additional, Rouge, A., additional, Schwartz, J., additional, Zinzius, P., additional, Popovic, B., additional, Sellal, J., additional, Aliot, E., additional, Juilliere, Y., additional, Selton-Suty, C., additional, Looi, J., additional, Lee, A., additional, Hsiung, M., additional, Song, W., additional, Wong, R., additional, Underwood, M. J., additional, Fang, F., additional, Lin, Q., additional, Lam, Y., additional, Yu, C., additional, Vitarelli, A., additional, Nguyen, B., additional, Capotosto, L., additional, D-Alessandro, G., additional, D-Ascanio, M., additional, Rafique, A., additional, Gang, E., additional, Barilla, F., additional, Siegel, R., additional, Kydd, A., additional, Khan, F., additional, Watson, W., additional, Mccormick, L., additional, Virdee, M., additional, Dutka, D., additional, Ranjbar, S., additional, Karvandi, M., additional, Hassantash, S., additional, Grapsa, J., additional, Efthimiadis, I., additional, Pakrashi, T., additional, Dawson, D., additional, Punjabi, P., additional, Nihoyannopoulos, P., additional, Henein, M., additional, Soderberg, S., additional, Tossavainen, E., additional, Lindqvist, P., additional, Bellsham-Revell, H., additional, Bell, A., additional, Miller, O., additional, Simpson, J., additional, Altekin, E., additional, Kucuk, M., additional, Yanikoglu, A., additional, Karakas, S., additional, Er, A., additional, Ozel, D., additional, Ermis, C., additional, Demir, I., additional, Bajraktari, G., additional, Di Salvo, G., additional, Baldini, L., additional, Del Gaizo, F., additional, Rea, A., additional, Pergola, V., additional, Pacileo, G., additional, Fadel, B., additional, Seo, J.-S., additional, Choi, G.-N., additional, Jin, H.-Y., additional, Seol, S.-H., additional, Jang, J.-S., additional, Yang, T.-H., additional, Kim, D.-K., additional, Kim, D.-S., additional, Papadopoulou, E., additional, Hatzidou, S., additional, Agrios, J., additional, Pamboukas, C., additional, Antoniou, A., additional, Gargiulo, P., additional, Dellegrottaglie, S., additional, Bruzzese, D., additional, Scala, O., additional, D'amore, C., additional, Ruggiero, D., additional, Marciano, C., additional, Vassallo, E., additional, Pirozzi, E., additional, Perrone Filardi, P., additional, Mor-Avi, V., additional, Kachenoura, N., additional, Lodato, J., additional, Port, S., additional, Chandra, S., additional, Freed, B., additional, Bhave, N., additional, Newby, B., additional, Patel, A., additional, Dwivedi, G., additional, Alam, M., additional, Boczar, K., additional, Chow, B., additional, Staskiewicz, G., additional, Czekajska-Chehab, E., additional, Uhlig, S., additional, Tomaszewski, A., additional, Przegalinski, J., additional, Maciejewski, R., additional, Drop, A., additional, Di Giammarco, G., additional, Canosa, C., additional, Foschi, M., additional, Liberti, G., additional, Bedir, M., additional, Marinelli, D., additional, Masuyama, S., additional, Rabozzi, R., additional, Vijayan, S., additional, Miller, H., additional, Muthusamy, R., additional, Smith, S., additional, Gargani, L., additional, Pang, P., additional, Davis, E., additional, Schumacher, A., additional, Sicari, R., additional, Picano, E., additional, Chmiel, A., additional, Mizia, M., additional, Haberka, M., additional, Gieszczyk, K., additional, Sikora - Puz, A., additional, Lasota, B., additional, Trojnarska, O., additional, Grajek, S., additional, Gasior, Z., additional, Koumoulidis, A., additional, Vlasseros, I., additional, Tousoulis, D., additional, Katsi, V., additional, Avgeropoulou, A., additional, Divani, M., additional, Stefanadis, C., additional, and Kallikazaros, I., additional

Published
2012
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36. Oral Abstract Sessions * Do we really need 3D echo to access heart valve?: 3D-TTE

Author

Stankovic, I., primary, Jasaityte, R., additional, Claus, P., additional, Voigt, J., additional, Muraru, D., additional, Cattarina, M., additional, Dal Bianco, L., additional, Peluso, D., additional, Zoppellaro, G., additional, Segafredo, B., additional, Calore, C., additional, Cucchini, U., additional, Iliceto, S., additional, Badano, L., additional, Tamborini, G., additional, Gripari, P., additional, Muratori, M., additional, Ghulam Ali, S., additional, Maffessanti, F., additional, Fusini, L., additional, Ferrari, C., additional, Alamanni, F., additional, Bartorelli, A., additional, Pepi, M., additional, Napodano, M., additional, Tarantini, G., additional, Sarais, C., additional, Kocabay, G., additional, Isabella, G., additional, Onofrio, A., additional, Gerosa, G., additional, Tsang, W., additional, Meineri, M., additional, Hahn, R., additional, Veronesi, F., additional, Osten, M., additional, Horlick, E., additional, and Lang, R., additional

Published
2012
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46. Club 35 Moderated Poster Session - Part B: 11/12/2013, 09:30-16:00 * Location: Moderated Poster area

Author

Tuluce, Kamil, Yakar Tuluce, Selcen, Isayev, Elnur, Bilgin, Murat, Yavuzgil, Oguz, Gurgun, Cemil, Nalbantgil, Sanem, Soydas Cinar, Cahide, Ozerkan, Filiz, Brandao Da Silva, D, Lehmann, R, Prinz, C, Horstkotte, D, Faber, L, Assabiny, A, Apor, A, Nagy, A, Vago, H, Toth, A, Merkely, B, Kovacs, A, Miglioranza, MH, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, Naso, P, Puma, L, Kocabay, G, Iliceto, S, Badano, LP, Marek, J, Ahmed, M, Ryo, K, Haugaa, K, Saba, S, and Gorcsan, J

Abstract

Background: Left atrial (LA) dysfunction and conduction alterations are observed in hypertrophic cardiomyopathy (HCM). P wave dispersion (PWD) reflects heterogenous atrial conduction. Another non-invasive method of assessing electrical events is the measurement of intra- and interatrial conduction times by tissue Doppler imaging (TDI). The aim of this study was to evaluate PWD, the intra- and interatrial asynchrony and their relations with LA volume index (LAVI), LA ejection fraction (LAEF) and plasma NT-proBNP levels in patients with HCM. Methods: Seventy patients with HCM and age and sex matched 70 subjects were enrolled. PWD was calculated on a high resolution computer screen after the magnification of ECG recordings. LA volume at end-ventricular systole (LAVmax) and end-atrial emptying (LAVmin) was assessed by TTE. LAEF was calculated as [(LAVmax-LAVmin)/LAVmax x 100]. Intra- and interatrial electromechanical conduction times were calculated by TDI. The time intervals from initiation of the P wave on ECG to the peak of the late diastolic TDI signal (A□) at the lateral border of the mitral (mitral PA□), septal (septal PA□) and the tricuspid annulus (tricuspid PA□) were measured. Interatrial asynchrony was defined as the difference between the mitral PA□ and tricuspid PA□ intervals, while intraatrial asynchrony as the difference between septal PA□ and tricuspid PA□ intervals. Plasma NT-proBNP levels were determined. Results: PWD was significantly higher in HCM group than in controls (43.5 ± 16.29 vs 37.07 ±10.61 ms, p=0.006). PWD correlated with LAVI (r=0.348, p=0.003) and LAEF (r=-0.242, p=0.044) but not related with log NT-proBNP levels (p=0.927). In HCM group interatrial electromechanical delay (42.29 ± 17.87 vs 27.64 ± 12.27 ms, p<0.001) and intraatrial electromechanical delay (25.43 ± 17.33 vs 13.57 ± 8.43 ms, p<0.001) were longer . Both intra- and interatrial asynchrony were not associated with LAVI, but significantly correlated with LAEF (r=-0.336, p=0.004 and r=-0.256, p=0.03, respectively). Intraatrial asynchrony was directly correlated with log NT-proBNP (r=0.309, p=0.012) in HCM group, while no association was detected between interatrial asynchrony and log NT-proBNP levels (p=0.102). Conclusion: Prolonged PWD, intra- and interatrial asynchrony were observed in patients with HCM and these parameters inversely correlated with LAEF. Intraatrial asynchrony was related to NT–proBNP levels. These observations seem to be related with fragmentation and slowing of atrial conduction activity which might be a result of atrial myopathy detected in HCM.

Published
2013
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47. Poster session Friday 13 December - AM: 13/12/2013, 08:30-12:30 * Location: Poster area

Author

Gertsen, M, Nemes, A, Szolnoky, G, Altmayer, A, Gavaller, H, Kemeny, L, Forster, T, Park, J R, Jo, SY, Kim, KH, Kho, JS, Kwack, CH, Hwang, JY, Popovic, D, Ostojic, MC, Petrovic, M, Vujisic-Tesic, B, Arandjelovic, A, Banovic, M, Vukcevic, V, Petrovic, I, Popovic, B, Damjanovic, S, Placido, R, Marta, L, Ramalho, AR, Nobre Menezes, M, Cortez-Dias, N, Martins, S, Goncalves, S, Almeida, AG, Silva-Marques, J, Nunes-Diogo, A, Germanakis, I, Kakouri, P, Karachaliou, M, Vassilaki, M, Chatzi, L, Roumeliotaki, T, Kogevinas, M, Horst, J-P, Kelter-Kloepping, A, Koerperich, H, Barth, P, Haas, NA, Kececioglu, D, Laser, KT, Laser, KT, Horst, J-P, Kelter-Kloepping, A, Barth, P, Haas, NA, Kececioglu, D, Koerperich, H, Samiei, N, Nabati, M, Azari-Jafari, M, Vakili-Zarch, A, Parsaee, M, Haghjoo, M, Ahmed, A J, Val-Mejias, J E, Von Bulow, F M, Baltussen, E J M, Darban, AM, Claus, P, Voigt, JU, Rodriguez Munoz, DA, Moya Mur, JL, Gonzalez, A, Garcia Martin, A, Becker Filho, D, Fernandez Santos, S, Lazaro Rivera, C, Recio Vazquez, M, Fernandez Golfin, C, Zamorano Gomez, JL, Bandera, F, Pellegrino, M, Generati, G, Alfonzetti, E, Donghi, V, Castelvecchio, S, Garatti, A, Menicanti, L, Guazzi, M, Kowalik, E, Klisiewicz, A, Hoffman, P, Kim, EJ, Cho, I J, Oh, J, Chang, HJ, Park, J, Shin, S, Shim, CY, Hong, GR, Ha, JW, Chung, N, Park, JH, Lee, HS, Kim, HS, Ahn, KT, Kim, JH, Lee, JH, Choi, SW, Jeong, JO, Seong, IW, Holzendorf, V, Gelbrich, G, Wachter, R, Loeffler, M, Pieske, BM, Broda, A, Edelmann, F, Failure, German Competence Network for Heart, Kim, YH, Kim, DH, Kim, SH, Ahn, JC, Song, WH, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Kusunose, Y, Nakamura, M, Sugi, K, De Knegt, M C, Biering-Sorensen, T, Sogaard, P, Sivertsen, J, Jensen, JS, Mogelvang, R, Murbraech, K, Smeland, KH, Holte, H, Loge, JH, Kiserud, CE, Aakhus, S, Peteiro, J, Gargallo-Fernandez, P, Garcia-Guimaraes, M, Bouzas-Mosquera, A, Yanez-Wronenburger, JC, Martinez-Ruiz, D, Castro-Beiras, A, Trzcinski, PT, Jaskowski, MJ, Nowak, JN, Pawlus, MP, Figiel, LF, Kasprzak, JDK, Lipiec, PL, Zhong, L, Su, Y, Teo, SK, Le, TT, Tan, RS, Tesic, M, Djordjevic-Dikic, A, Giga, V, Jovanovic, I, Paunovic, I, Petrovic, MT, Trifunovic, D, Beleslin, B, Stepanovic, J, Vujisic-Tesic, B, Parato, V M, Partemi, M, Nardini, E, Pasanisi, E, Park, T-H, Lee, J-E, Lee, D-H, Park, J-S, Park, K, Kim, M-H, Kim, Y-D, Vegsundvag, J, Holte, E, Wiseth, R, Hegbom, K, Hole, T, Fusini, L, Tamborini, G, Ghulam Ali, S, Muratori, M, Gripari, P, Cefalu, C, Maffessanti, F, Celeste, F, Alamanni, F, Pepi, M, Negrea, SL, Alexandrescu, C, Rossi, P, Iacuzio, L, Dreyfus, G, Moatemri, F, Mahdhaoui, A, Bouraoui, H, Ernez, S, Jeridi, G, Yuan, L, Feng, JL, Jin, X Y, Seoane Garcia, T, Delgado Ortega, M, Mesa Rubio, D, Ruiz Ortiz, M, Martin Hidalgo, M, Carrasco Avalos, F, Casares Mediavilla, J, Alados, P, Lopez Granados, A, Suarez De Lezo Cruz Conde, J, Mutuberria Urdaniz, M, Rodriguez-Palomares, JF, Baneras-Rius, JF, Acosta-Velez, JG, Buera-Surribas, I, Gonzalez-Alujas, MT, Teixido, G, Evangelista, A, Tornos, P, Garcia-Dorado, D, Iliuta, L, Boerlage-Van Dijk, K, Van Riel, ACMJ, De Bruin-Bon, HACM, Wiegerinck, EMA, Koch, KT, Vis, MM, Meregalli, PG, Piek, JJ, Bouma, BJ, Baan, J, Enache, R, Muraru, D, Piazza, R, Popescu, BA, Coman, M, Calin, A, Rosca, M, Beladan, CC, Nicolosi, GL, Ginghina, C, Song, JM, Kim, JJ, Ha, TY, Jung, SH, Hwang, IS, Lee, IC, Sun, BJ, Kim, DH, Kang, DH, Song, JK, Sturmberger, T, Ebner, CE, Aichinger, J, Tkalec, W, Niel, J, Steringer-Mascherbauer, R, Kabicher, G, Winter, S, Nesser, HJ, Hofmann-Bowman, M, Lin Yan, LY, Puri, TP, Chin, C W L, Doris, M, Shah, A, Mills, N, Semple, S, Prasad, S, White, A, Dweck, M, Newby, D, Debonnaire, P, Al Amri, I, Leong, DP, Joyce, E, Katsanos, S, Kamperidis, V, Schalij, MJ, Bax, JJ, Ajmone Marsan, N, Delgado, V, Cerin, G, Popa, B A, Lanzillo, G, Benea, D, Karazanishvili, L, Diena, M, Dedobbeleer, C, Schnell, F, Jotrand, E, El Mourad, M, Thebault, C, Plein, D, Donal, E, Unger, P, Spampinato, RA, Tasca, M, Da Rocha E Silva, JG, Strotdrees, E, Schloma, V, Dmitrieva, Y, Mende, M, Borger, MA, Mohr, FW, Veronesi, F, Muraru, D, Addetia, K, Corsi, C, Lamberti, C, Lang, RM, Mor-Avi, V, Badano, LP, Zemanek, D, Tomasov, P, Belehrad, M, Kara, T, Veselka, J, Igual Munoz, B, Estornell Erill, JORDI, Maceira Gonzalez Alicia, AMG, Monmeneu Menadas, JVMM, Lopez Lereu Pilar, PLL, Molina Aguilar, PMA, Domingo-Valero, DDV, Osca Asensi, JOA, Zorio Grima, EZG, Salvador Sanz Antonio, ASS, Ibrahimi, P, Bajraktari, G, Poniku, A, Hysenaj, V, Ahmeti, A, Jashari, F, Haliti, E, Henein, MY, Maramao, F, Conde, Y, Maramao, L, Rulli, F, Roussin, I, Drakopoulou, M, Bhattacharyya, S, Simpkin, V, Sharma, R, Rosen, S, Prasad, S, Senior, R, Lyon, AR, Kimura, K, Tanimoto, T, Akasaka, T, Fijalkowski, M, Jaguszewski, M, Fijalkowska, M, Nowak, R, Galaska, R, Rojek, A, Narkiewicz, K, Rynkiewicz, A, Azevedo, O, Marques, N, Cruz, I, Picarra, B, Lima, R, Amado, J, Pereira, V, Almeida, AR, SUNSHINE, Zito, C, Crea, P, Cusma Piccione, M, Vriz, O, Bitto, A, Minisini, R, Madaffari, A, Acri, E, Oteri, A, Carerj, S, Leggio, S, Buccheri, S, Tamburino, C, Monte, I P, Mihalcea, D, Florescu, M, Enescu, OA, Magda, LS, Radu, E, Acasandrei, AM, Balanescu, P, Rimbas, RC, Jinga, D, Vinereanu, D, 112/2011, Research grant, Miyoshi, T, Tanaka, H, Kaneko, A, Matsumoto, K, Imanishi, J, Motoji, Y, Mochizuki, Y, Minami, H, Kawai, H, Hirata, K, Ryu, SK, Shin, DG, Son, JW, Choi, JH, Goh, CW, Choi, JW, Park, JY, Hong, GR, Le Page, P, Mitchell, ARJ, Maclachlan, HI, Hurry, RW, Villagraz Tecedor, L, Jimenez Lopez Guarch, C, Alonso Chaterina, S, Mayordomo Gomez, S, Blazquez Arrollo, L, Lombera Romero, F, Lopez Melgar, B, Escribano Subias, MP, Lichodziejewska, B, Kurnicka, K, Goliszek, S, Kostrubiec, M, Dzikowska Diduch, O, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Lovric, D, Carmona, C, Bergerot, C, Schnell, F, Thibault, H, Barthelet, M, Ninet, J, Revel, D, Croisille, P, Derumeaux, G, Jensen, MT, Rossing, P, Sogaard, P, Andersen, HU, Bech, J, Hansen, TF, Gustafsson, I, Galatius, S, Jensen, JS, Shang, Q, Zhang, Q, Sanderson, JE, Tam, LS, Lee, A PW, Fang, F, Li, E KM, Yu, CM, Bruin De- Bon, HACM, Tan, HL, Hardziyenka, M, Symersky, P, Bonta, PI, Brink Van Den, RBA, Bouma, BJ, Bader, RS, Punn, R, Silverman, N, Cruz, C, Pinho, T, Lebreiro, A, Dias, CC, Silva Cardoso, J, Julia Maciel, M, Melao, F, Ribeiro, V, Cruz, C, Maciel, MJ, Attenhofer Jost, C H, Schmidt, D, Pfyffer, M, Biaggi, P, Seifert, B, Weber, R, De Pasquale, G, Kretschmar, O, Seeliger, T, Greutmann, M, Johansson, M C, Mirzada, N, Ladenvall, P, Besiroglu, F, Samadov, F, Atas, H, Sari, I, Tufekcioglu, O, Birincioglu, CL, Acar, B, Duman, I, Colak, A, Zagatina, A, Krylova, L, Zhuravskaya, N, Vareldzhyan, Y, Tyurina, TV, Clitsenko, O, Castro, M, Dores, H, Carvalho, MS, Reis, C, Horta, E, Trabulo, MS, Andrade, MJ, Mendes, M, Gasior, Z, Plonska-Gosciniak, E, Wita, K, Mizia-Stec, K, Kulach, A, Szwed, H, Chrzanowski, L, Tomaszewski, A, Sinkiewicz, W, Wojciechowska, C, Aggeli, C, Felekos, I, Stergiou, P, Roussakis, G, Kakiouzi, V, Kastellanos, S, Koutagiar, I, Stefanadis, C, Bouzas Mosquera, A, Peteiro, J, Alvarez-Garcia, N, Broullon, FJ, Garcia-Guimaraes, MM, Martinez-Ruiz, D, Yanez-Wonenburger, JC, Bouzas-Zubeldia, B, Fabregas, R, Castro-Beiras, A, Brugger, N, Huerzeler, M, Wustmann, K, Wahl, A, Steck, H, Seiler, C, Sarwar, R, Malhotra, A, Wong, KC, Betts, TR, Bashir, Y, Rajappan, K, Newton, JD, Casanova Rodriguez, C, Cano Carrizal, R, Iglesias Del Valle, D, Martin Penato Molina, A, Garcia Garcia, A, Prieto Moriche, E, Alvarez Rubio, J, Paredes Gonzalez, B, De Juan Baguda, J, Plaza Perez, I, Van Den Oord, SCH, Akkus, Z, Roeters Van Lennep, JE, Bosch, JG, Van Der Steen, AFW, Sijbrands, EJG, Schinkel, AFL, Muraru, D, Calore, C, Badano, LP, Melacini, C, Mihaila, S, Peluso, D, Puma, L, Kocabay, G, Rizzon, G, Iliceto, S, Bochard Villanueva, B, Paya-Serrano, R, Garcia-Gonzalez, P, Fabregat-Andres, O, Perez-Bosca, JL, Cubillos-Arango, A, Ferrando-Beltran, M, Chacon-Hernandez, N, Albiach-Montanana, C, Ridocci-Soriano, F, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Tarr, A, Stoebe, S, Pfeiffer, D, Hagendorff, A, Hollekim, SM, Bjorgaas, MR, Tjonna, AE, Wisloff, U, Ingul, CB, (CERG), Cardiac Exercise Research Group, Oreto, L, Zito, C, Cusma-Piccione, M, Calabro, MP, Todaro, MC, Vita, GL, Messina, S, Vita, G, Sframeli, M, Carerj, S, Remoli, R, Lamberti, F, Bellini, C, Mercurio, M, Dottori, S, Bellusci, F, Mazzuca, V, Gaspardone, A, Rimbas, RC, Enescu, OA, Mihaila, S, Ciobanu, A, Vinereanu, D, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Wellnhofer, E, Kriatselis, C, Gerds-Li, H, Furundzija, VESNA, Thanabalasingam, U, Fleck, E, Graefe, M, Kouris, N, Keramida, K, Karidas, V, Kostopoulos, V, Kostakou, P, Mprempos, G, Olympios, CD, Duchateau, N, Giraldeau, G, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Bernard, A, Donal, E, Reynaud, A, Schnell, F, Daubert, JC, Leclercq, C, Hernandez, A, Keramida, K, Kouris, N, Kostopoulos, V, Karidas, V, Dagre, A, Ntarladimas, I, Damaskos, D, Stamatelatou, M, Olympios, CD, Panetta, G L, Peraldo Neja, C, Urbano Moral, JA, Evangelista, A, Azzolini, P, Gaudio, C, Pandian, NG, Barbier, P, Mirea, O, Savioli, G, Cefalu, C, Guglielmo, M, Fusini, L, Maltagliati, A, Hamdy, AM, Fereig, HM, Nabih, MA, Abdel-Aziz, A, Ali, AA, Buccheri, S, Mangiafico, S, Leggio, S, B, VE, Tropea, L, Tamburino, C, Monte, I P, Garcia-Gonzalez, P, Chacon-Hernandez, N, Cozar-Santiago, P, Fabregat-Andres, O, Sanchez-Jurado, R, Higueras-Ortega, L, Albiach-Motanana, C, Perez-Bosca, JL, Paya-Serrano, R, Ridocci-Soriano, F, Flori, M, Valette, F, Guijarro, D, Pallardy, A, Le Tourneau, T, Kraeber-Bodere, F, Piriou, N, Saxena, A, Ramakrishnan, S, Tulunay Kaya, C, Ongun, A, Kilickap, M, Candemir, B, Altin, AT, Gerede, M, Ozcan, OU, Erol, C, Yue, WS, Yang, F, Huang, D, Gu, P, Luo, Y, Lv, Z, Siu, CW, Tse, HF, Yiu, KH, Saura Espin, D, Lopez Cuenca, A, Espinosa Garcia, MD, Oliva Sandoval, MJ, Lopez Ruiz, M, Gonzalez Carrillo, J, Garcia Navarro, MJ, Valdes Chavarri, M, De La Morena Valenzuela, G, Gustafsson, U, Spuhler, JH, Hoffman, J, Brodin, LÅ, Kisko, A, Dernarova, L, Hudakova, A, Santova, T, Jakubikova, M, Mikulak, M, Horlenko, O, Kishko, N, Svystak, V, Shyp, A, Faden, G, Gaibazzi, N, Rigo, F, Mureddu, GF, Moreo, A, Bussadori, G, Facchetti, R, Cesana, F, Giannattasio, C, Faggiano, P, and group, APRES collaborative

Abstract

Pulmonary vascular dysfunction is claimed to be a contributor to the development of pulmonary hypertension (PH). Impaired systemic vascular reactivity is one of the essential factors in the pathogenesis of cardiovascular disease. The aim of the investigation was to study whether there is any association between systemic vascular function and pulmonary artery pressure (PAP) in patients who have associated causes for PH development, such as coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD). Methods: The brachial artery vasodilator responses were measured by the ultrasound technique in twenty patients with mild to moderate COPD (group I) and twenty age–matched and COPD stage-matched patients who had past history of myocardial infarction (NYHA II) (group II).Conventional echocardiographic variables were measured in the said patients too. Results: Both flow-mediated dilatation (FMD) and nitrate-mediated dilatation (NMD) were significantly lower, and PAP was significantly higher in the group II patients compared to the same parameters of group I patients. NMD was inversely correlated with PAP (r=-0.7, p=0.02) in group I patients. There was no interrelation between FMD and PAP in patients from group I. Neither FMD nor NMD were correlated with PAP in group II patients. A significant positive correlation between PAP and left ventricular mass index (r=0.8, p=0.003) was revealed in the said patients as well. Conclusions: Attenuated vasodilator response of brachial artery to nitroglycerine is associated with PAP elevation in COPD patients. PH is closely related to cardiac remodeling in COPD patients in whom CHD developed. These data suggest different "stages" of vascular and cardiac remodeling in patients with COPD alone and in coexistence with CHD. The obtained data can be useful in the selection of treatment as regards these patient categories.

Published
2013
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48. Normal Left Ventricular Mechanics by Two-dimensional Speckle-tracking Echocardiography. Reference Values in Healthy Adults

Author

Sabino Iliceto, Gonenc Kocabay, Sorina Mihaila, Umberto Cucchini, Diletta Peluso, Luigi P. Badano, Denas Gentian, Dragos Vinereanu, Denisa Muraru, Seena Padayattil-Jose, Kocabay, G, Muraru, D, Peluso, D, Cucchini, U, Mihaila, S, PADAYATTIL JOSE, S, Denas, G, Iliceto, S, Vinereanu, D, and Badano, L

Subjects
Male, Left, Hemodynamics, Speckle tracking echocardiography, Ventricular Function, Left, Standard deviation, Heart Ventricle, Normal participants, Reference Values, Deformación miocárdica, Healthy volunteers, 80 and over, Ecocardiografía speckle tracking, Giro, Healthy participants, Individuos normales, Individuos sanos, Left ventricle, Myocardial deformation, Reference values, Speckle-tracking echocardiography, Strain bidimensional, Twist, Two-dimensional strain, Valores de referencia, Ventrículo izquierdo, Adolescent, Adult, Aged, Aged, 80 and over, Echocardiography, Female, Healthy Volunteers, Heart Ventricles, Humans, Middle Aged, Young Adult, Cardiology and Cardiovascular Medicine, Ventricular Function, Reference Value, Ejection fraction, Strain (chemistry), General Medicine, Healthy Volunteer, Cardiology, Radial stress, Human, medicine.medical_specialty, Internal medicine, medicine, Normal participant, business.industry, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Surgery, Strain bi-dimensional, business
Abstract

Introduction and objectives Two-dimensional speckle-tracking echocardiography is a novel tool to assess myocardial function. The purpose of this study was to evaluate left ventricular myocardial strain and rotation parameters by two-dimensional speckle-tracking echocardiography in a large group of healthy adults across a wide age range to establish their reference values and to assess the influence of age, sex, and hemodynamic factors. Methods Transthoracic echocardiograms were acquired in 247 healthy volunteers (139 women, 44 years [standard deviation, 16 years old] (range, 18-80 years). We measured longitudinal, circumferential, and radial peak systolic strain values, and left ventricular rotation and twist. Results Average values of global longitudinal, radial, and circumferential strain were -21.5% (standard deviation, 2.0%), 40.1% (standard deviation, 11.8%) and -22.2% (standard deviation, 3.4%), respectively. Longitudinal strain was significantly more negative in women, whereas radial and circumferential strain and rotational parameters were similar in both sexes. Accordingly, lower limits of normality for the strain components were -16.9% in men and -18.5% in women for longitudinal strain, and -15.4% for circumferential and 24.6% for radial strain, irrespective of sex. Longitudinal strain values were more negative at the base than at apical segments. Mean rotational values were -6.9 ° (standard deviation, 3.5 °) for the base, 13.0 ° (standard deviation, 6.5 °) for apical rotation, and 20.0 ° (standard deviation, 7.3 °) for net twist. Conclusions We report the comprehensive assessment of normal myocardial deformation and rotational mechanics in a large cohort of healthy volunteers. We found that women have more negative longitudinal strain, accounting for their higher left ventricular ejection fraction. Availability of reference values for these parameters may foster their implementation in the clinical routine. Full English text available from: www.revespcardiol.org/en. © 2013 Sociedad Española de Cardiología. Published by Elsevier España, S.L. All rights reserved.

Published
2014

49. Ascending aorta diameters measured by echocardiography using both leading edge-to-leading edge and inner edge-to-inner edge conventions in healthy volunteers

Author

Diletta Peluso, Lucia Dal Bianco, Eleonora Piasentini, Denisa Muraru, Francesco Maffessanti, Seena Padayattil Jose, Sabino Iliceto, Gonenc Kocabay, Luigi P. Badano, Muraru, D, Maffessanti, F, Kocabay, G, Peluso, D, Bianco Lucia, D, Piasentini, E, Jose Seena, P, Iliceto, S, and Badano, L

Subjects
Male, Normal limit, Diastole, Risk Factors, Cardiovascular Disease, Nuclear Medicine and Imaging, 80 and over, Aortic root, Reference Value, Prospective Studies, Aorta, Aged, 80 and over, Body surface area, Medicine (all), Sinotubular Junction, Aortic stiffness, Body size, General Medicine, Anatomy, Middle Aged, Healthy Volunteer, Sinotubular junction, Healthy Volunteers, Aortic stiffne, Echocardiography, Cardiovascular Diseases, Tubular aorta, Female, Radiology, Cardiology and Cardiovascular Medicine, Human, Adult, Leading edge, Adolescent, Systole, Reproducibility of Result, Risk Assessment, Reference values, Age, medicine.artery, Ascending aorta, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Normal limits, business.industry, Risk Factor, Gender, Reproducibility of Results, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Reference Values, Radiology, Nuclear Medicine and Imaging, Prospective Studie, Nuclear medicine, business
Abstract

AIMS: Reference ranges of ascending aorta diameters (AAoD) for two-dimensional echocardiography (2DE) using inner edge (IE) convention are lacking, preventing the comparison of AAoD measurements by 2DE with those obtained by other imaging modalities. METHODS AND RESULTS: We used harmonic imaging 2DE to prospectively study 218 healthy volunteers (56% women, 42 ± 15 years, 18-80 years). Measurements were performed at the level of aortic root (AoR), sinotubular junction (STJ), and proximal tubular portion (TAo, 1 cm from the STJ) using both leading edge (LE) and IE conventions at end-diastole and end-systole. Feasibility of AAoD measurements between end-diastole and end-systole was similar at AoR and STJ levels, but it was significantly different at TAo level (82 vs. 96%, respectively, P < 0.0001). Ascending aorta diameters indexed to height were larger in men than in women (P < 0.0001). After adjusting for the effect of gender, only age and body surface area (BSA) were independent predictors of AAoD at multivariable analysis. Average end-diastolic AoR, STJ, and TAo diameters measured using IE convention were similar between genders (17 ± 2, 15 ± 2, and 15 ± 2 mm/m(2), respectively). Corresponding AAoD measured using the LE convention were 18 ± 2, 16 ± 2, and 17 ± 4 mm/m(2), respectively. On average, the end-systolic AAoD measured using LE were 2 mm larger than those performed using IE or at end-diastole. Mean aortic wall thickness was 2.4 ± 0.8 mm. CONCLUSION: End-diastolic AAoD measured using IE were significantly smaller than those obtained either using LE convention or at end-systole. Gender-specific reference values for AAoD indexed for BSA should be used to identify ascending aorta pathology.

Published
2013

50. Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: a two- and three-dimensional echocardiographic study

Author

Cesare Cuspidi, Branislava Ivanovic, Tamara Marjanovic, Sanja Ilic, Vera Celic, Dejana Stanisavljevic, Gonenc Kocabay, Marijana Tadic, Biljana Pencic, Jana Radojkovic, Tadic, M, Celic, V, Cuspidi, C, Ilic, S, Pencic, B, Radojkovic, J, Ivanovic, B, Stanisavljevic, D, Kocabay, G, and Marjanovic, T

Subjects
Male, medicine.medical_specialty, Diabetes mellitu, Ventricular Dysfunction, Right, Echocardiography, Three-Dimensional, Speckle-tracking imaging, Three-dimensional echocardiography, Right atrial, Sensitivity and Specificity, Prediabetic State, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, Image Interpretation, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prediabetes, Body surface area, Right atrium, business.industry, Type 2 Diabetes Mellitus, Reproducibility of Results, Stroke Volume, Mechanics, Middle Aged, medicine.disease, chemistry, Diabetes Mellitus, Type 2, Right heart, Prediabete, Cardiology, Right ventricle, Elasticity Imaging Techniques, Female, Glycated hemoglobin, MED/09 - MEDICINA INTERNA, Cardiology and Cardiovascular Medicine, business, Body mass index
Abstract

Background: The aim of this study was to determine right ventricular (RV) and right atrial (RA) deformation assessed by two-dimensional echocardiographic and three-dimensional echocardiographic (3DE) imaging in patients with prediabetes and type 2 diabetes mellitus. Methods: This cross-sectional study included 47 untreated normotensive subjects with prediabetes, 57 recently diagnosed normotensive patients with diabetes, and 54 healthy controls of similar sex and age distributions. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. Results: Three-dimensional echocardiographic RV end-diastolic volume index gradually decreased from controls across patients with diabetes to those with diabetes (69 ± 10 vs 63 ± 8 vs 58 ± 8mL/m2, P < .001), whereas 3DE RV end-systolic volume index was higher in controls compared with patients with diabetes and those with diabetes (25 ± 4 vs 23 ± 4vs 22 ± 4mL/m2, P < .001). However, there was no difference in 3DE RV ejection fraction among the three groups (63 ± 4% vs 62 ± 4% vs 61 ± 5%, P = .063). RV and RA global strain and systolic and early diastolic strain rates were decreased in patients with prediabetes and in those with diabetes compared with controls, whereas RV and RA late diastolic strain rates were increased in these patients. Multivariate regression analysis showed that RV global strain was associated with glycated hemoglobin, independent of left ventricular parameters. Conclusions: RV and RA myocardial deformation and function obtained by 3DE and two-dimensional echocardiographic strain, even in normal ranges, were decreased in patients with prediabetes and in those with diabetes compared with controls. The long-term parameter of glucose control was correlated with the right heart mechanics.

Published
2014

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