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480 results on '"Kobayashi, Natsuko"'

3. Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Author

Murakami, Keiko, Ishikuro, Mami, Obara, Taku, Ueno, Fumihiko, Noda, Aoi, Onuma, Tomomi, Matsuzaki, Fumiko, Takahashi, Ippei, Kikuchi, Saya, Kobayashi, Natsuko, Hamada, Hirotaka, Iwama, Noriyuki, Metoki, Hirohito, Kikuya, Masahiro, Saito, Masatoshi, Sugawara, Junichi, Tomita, Hiroaki, Yaegashi, Nobuo, and Kuriyama, Shinichi

Published
2024
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4. Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Author

Murakami, Keiko, Noda, Aoi, Ishikuro, Mami, Obara, Taku, Ueno, Fumihiko, Onuma, Tomomi, Kikuchi, Saya, Kobayashi, Natsuko, Hamada, Hirotaka, Iwama, Noriyuki, Metoki, Hirohito, Kikuya, Masahiro, Saito, Masatoshi, Sugawara, Junichi, Tomita, Hiroaki, Yaegashi, Nobuo, and Kuriyama, Shinichi

Published
2023
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9. Awareness of Infectious Disease Screening During Early Pregnancy and Knowledge About its Vertical Transmission in Japan: A Report from the Pregnant Women Health Initiative

Author

Odagami, Mizuha, Iwata, Akiko, Kubota, Kazumi, Kurasawa, Kentaro, Okuda, Mika, Aoki, Shigeru, Hirabuki, Tomoo, Tujie, Tomoko, Saji, Haruya, Hasegawa, Tetsuya, Kobayashi, Natsuko, Ueda, Yutaka, Ishioka, Shinichi, Enomoto, Takayuki, Tsuji, Makoto, Shigeta, Hiroyuki, Koike, Kumi, Tanaka, Hiroaki, Tsukinaga, Rie, Hasegawa, Yoshimi, Numazaki, Reiko, Ota, Hajime, Kase, Hiroaki, Ishikawa, Hiroshi, Saito, Yoshihiro, Yamawaki, Takaharu, and Miyagi, Etsuko

Published
2023
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10. Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Author

Murakami, Keiko, Noda, Aoi, Ishikuro, Mami, Obara, Taku, Ueno, Fumihiko, Onuma, Tomomi, Matsuzaki, Fumiko, Kikuchi, Saya, Kobayashi, Natsuko, Hamada, Hirotaka, Iwama, Noriyuki, Metoki, Hirohito, Kikuya, Masahiro, Saito, Masatoshi, Sugawara, Junichi, Tomita, Hiroaki, Yaegashi, Nobuo, and Kuriyama, Shinichi

Published
2023
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12. Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Author

Murakami, Keiko, Ishikuro, Mami, Obara, Taku, Noda, Aoi, Ueno, Fumihiko, Onuma, Tomomi, Matsuzaki, Fumiko, Takahashi, Ippei, Kikuchi, Saya, Kobayashi, Natsuko, Hamada, Hirotaka, Iwama, Noriyuki, Metoki, Hirohito, Kikuya, Masahiro, Saito, Masatoshi, Sugawara, Junichi, Tomita, Hiroaki, Yaegashi, Nobuo, and Kuriyama, Shinichi

Published
2023
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13. Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Author

Murakami, Keiko, Ishikuro, Mami, Obara, Taku, Ueno, Fumihiko, Noda, Aoi, Onuma, Tomomi, Matsuzaki, Fumiko, Kikuchi, Saya, Kobayashi, Natsuko, Hamada, Hirotaka, Iwama, Noriyuki, Metoki, Hirohito, Kikuya, Masahiro, Saito, Masatoshi, Sugawara, Junichi, Tomita, Hiroaki, Yaegashi, Nobuo, and Kuriyama, Shinichi

Published
2023
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14. Plasma metabolic disturbances during pregnancy and postpartum in women with depression

Author

Yu, Zhiqian, Matsukawa, Naomi, Saigusa, Daisuke, Motoike, Ikuko N., Ono, Chiaki, Okamura, Yasunobu, Onuma, Tomomi, Takahashi, Yuta, Sakai, Mai, Kudo, Hisaaki, Obara, Taku, Murakami, Keiko, Shirota, Matusyuki, Kikuchi, Saya, Kobayashi, Natsuko, Kikuchi, Yoshie, Sugawara, Junichi, Minegishi, Naoko, Ogishima, Soichi, Kinoshita, Kengo, Yamamoto, Masayuki, Yaegashi, Nobuo, Kuriyama, Shinichi, Koshiba, Seizo, and Tomita, Hiroaki

Published
2022
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17. Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Author

Takahashi, Ippei, Murakami, Keiko, Kobayashi, Mika, Kikuchi, Saya, Igarashi, Ayaka, Obara, Taku, Ishikuro, Mami, Ueno, Fumihiko, Noda, Aoi, Onuma, Tomomi, Matsuzaki, Fumiko, Kobayashi, Natsuko, Hamada, Hirotaka, Iwama, Noriyuki, Saito, Masatoshi, Sugawara, Junichi, Tomita, Hiroaki, Yaegashi, Nobuo, Kure, Shigeo, and Kuriyama, Shinichi

Published
2022
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18. Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study.

Author

Takahashi, Ippei, Obara, Taku, Kikuchi, Saya, Kobayashi, Natsuko, Obara, Ryo, Noda, Aoi, Ohsawa, Minoru, Ishikawa, Tomofumi, Mano, Nariyasu, Nishigori, Hidekazu, Ueno, Fumihiko, Shinoda, Genki, Murakami, Keiko, Orui, Masatsugu, Ishikuro, Mami, Tomita, Hiroaki, and Kuriyama, Shinichi

Published
2024
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22. Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Author

Ohseto, Hisashi, primary, Takahashi, Ippei, additional, Narita, Akira, additional, Obara, Taku, additional, Ishikuro, Mami, additional, Kobayashi, Natsuko, additional, Kikuchi, Saya, additional, Li, Xue, additional, Noda, Aoi, additional, Murakami, Keiko, additional, Tamiya, Gen, additional, Sugawara, Junichi, additional, Tomita, Hiroaki, additional, and Kuriyama, Shinichi, additional

Published
2024
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24. A New Ultrasonographic “Fluttering Sign” for Hepatic Hemangioma

Author

Kobayashi, Natsuko, Iijima, Hiroko, Tada, Toshifumi, Shibata, Yoko, Nishimura, Takashi, Kumada, Takashi, Hashimoto, Mariko, Higashiura, Akiko, Yoshida, Masahiro, Nishimura, Junko, Aizawa, Nobuhiro, Ikeda, Naoto, Takashima, Tomoyuki, Takata, Ryo, Nishikawa, Hiroki, Iwata, Yoshinori, Enomoto, Hirayuki, Hirota, Seiichi, and Hatano, Etsuro

Published
2021
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25. OsHKT1;4-mediated Na+ transport in stems contributes to Na+ exclusion from leaf blades of rice at the reproductive growth stage upon salt stress

Author

Suzuki, Kei, Yamaji, Naoki, Costa, Alex, Okuma, Eiji, Kobayashi, Natsuko I, Kashiwagi, Tatsuhiko, Katsuhara, Maki, Wang, Cun, Tanoi, Keitaro, Murata, Yoshiyuki, Schroeder, Julian I, Ma, Jian Feng, and Horie, Tomoaki

Subjects
Agricultural, Veterinary and Food Sciences, Crop and Pasture Production, Animals, Cation Transport Proteins, Gene Expression Profiling, Genes, Plant, Ion Transport, Oocytes, Oryza, Phenotype, Plant Leaves, Plant Proteins, Plant Stems, Protoplasts, RNA Interference, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Sodium, Sodium Chloride, Stress, Physiological, Symporters, Xenopus laevis, Salinity stress, Na+ transport, HKT, Rice, Microbiology, Plant Biology, Plant Biology & Botany, Crop and pasture production, Plant biology
Abstract

BackgroundNa(+) exclusion from leaf blades is one of the key mechanisms for glycophytes to cope with salinity stress. Certain class I transporters of the high-affinity K(+) transporter (HKT) family have been demonstrated to mediate leaf blade-Na(+) exclusion upon salinity stress via Na(+)-selective transport. Multiple HKT1 transporters are known to function in rice (Oryza sativa). However, the ion transport function of OsHKT1;4 and its contribution to the Na(+) exclusion mechanism in rice remain to be elucidated.ResultsHere, we report results of the functional characterization of the OsHKT1;4 transporter in rice. OsHKT1;4 mediated robust Na(+) transport in Saccharomyces cerevisiae and Xenopus laevis oocytes. Electrophysiological experiments demonstrated that OsHKT1;4 shows strong Na(+) selectivity among cations tested, including Li(+), Na(+), K(+), Rb(+), Cs(+), and NH4 (+), in oocytes. A chimeric protein, EGFP-OsHKT1;4, was found to be functional in oocytes and targeted to the plasma membrane of rice protoplasts. The level of OsHKT1;4 transcripts was prominent in leaf sheaths throughout the growth stages. Unexpectedly however, we demonstrate here accumulation of OsHKT1;4 transcripts in the stem including internode II and peduncle in the reproductive growth stage. Moreover, phenotypic analysis of OsHKT1;4 RNAi plants in the vegetative growth stage revealed no profound influence on the growth and ion accumulation in comparison with WT plants upon salinity stress. However, imposition of salinity stress on the RNAi plants in the reproductive growth stage caused significant Na(+) overaccumulation in aerial organs, in particular, leaf blades and sheaths. In addition, (22)Na(+) tracer experiments using peduncles of RNAi and WT plants suggested xylem Na(+) unloading by OsHKT1;4.ConclusionsTaken together, our results indicate a newly recognized function of OsHKT1;4 in Na(+) exclusion in stems together with leaf sheaths, thus excluding Na(+) from leaf blades of a japonica rice cultivar in the reproductive growth stage, but the contribution is low when the plants are in the vegetative growth stage.

Published
2016

26. Experiences of perinatal women and public healthcare providers in a community affected by the great east Japan earthquake and tsunami: Concerns that must be considered for the mental healthcare of perinatal women in postdisaster settings

Author

Kobayashi, Natsuko, Nemoto, Harumi, Seto, Moe, Sato, Shosuke, Kikuchi, Saya, Honda, Nami, Suzuki, Tomomi, Sato, Kineko, Sugawara, Junichi, Ito, Kiyoshi, Kayano, Ryoma, Ozaki, Norio, Beadling, Charles W., Kelman, Ilan, Imamura, Fumihiko, Matsuoka, Hiroo, and Tomita, Hiroaki

Published
2020
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27. An Observational Study of Pigs Exposed to Radiation

Author

Li, Junyou, Piao, Chunxiang, Iitsuka, Hirohiko, Ikeda, Masanori, Takahashi, Tomotsugu, Kobayashi, Natsuko, Hirose, Atsushi, Tanoi, Keitaro, Nakanishi, Tomoko, Kuwahara, Masayoshi, Nakanishi, Tomoko M., editor, O`Brien, Martin, editor, and Tanoi, Keitaro, editor

Published
2019
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29. Cesium Translocation in Rice

Author

Tanoi, Keitaro, Nobori, Tatsuya, Shiomi, Shuto, Saito, Takumi, Kobayashi, Natsuko I., Leonhardt, Nathalie, Nakanishi, Tomoko M., Nakanishi, Tomoko M., editor, O`Brien, Martin, editor, and Tanoi, Keitaro, editor

Published
2019
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36. Usefulness of Attenuation Imaging with an Ultrasound Scanner for the Evaluation of Hepatic Steatosis

Author

Tada, Toshifumi, Iijima, Hiroko, Kobayashi, Natsuko, Yoshida, Masahiro, Nishimura, Takashi, Kumada, Takashi, Kondo, Reiichiro, Yano, Hirohisa, Kage, Masayoshi, Nakano, Chikage, Aoki, Tomoko, Aizawa, Nobuhiro, Ikeda, Naoto, Takashima, Tomoyuki, Yuri, Yukihisa, Ishii, Noriko, Hasegawa, Kunihiro, Takata, Ryo, Yoh, Kazunori, Sakai, Yoshiyuki, Nishikawa, Hiroki, Iwata, Yoshinori, Enomoto, Hirayuki, Hirota, Seiichi, Fujimoto, Jiro, and Nishiguchi, Shuhei

Published
2019
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37. Metabolic dysfunction‐associated steatotic liver disease criteria may underestimate the number of lean female nonalcoholic fatty liver disease patients with significant liver fibrosis.

Author

Kobayashi, Natsuko, Tada, Toshifumi, Nishimura, Takashi, Matono, Tomomitsu, Yuri, Yukihisa, Takashima, Tomoyuki, Aizawa, Nobuhiro, Ikeda, Naoto, Fukunishi, Shinya, Hashimoto, Mariko, Ohyanagi, Mitsumasa, Enomoto, Hirayuki, and Iijima, Hiroko

Subjects
*NON-alcoholic fatty liver disease, *HEPATIC fibrosis, *LIVER diseases, *DIAGNOSTIC ultrasonic imaging, *BODY mass index
Abstract

Aim: It remains unclear whether the newly defined concept of metabolic dysfunction‐associated steatotic liver disease (MASLD) appropriately includes patients with nonalcoholic fatty liver disease with significant liver fibrosis. Methods: A total of 4112 patients in whom nonalcoholic fatty liver disease was diagnosed by ultrasonography during medical checkups were enrolled. We defined a fibrosis‐4 index ≥1.3 in patients aged <65 years and ≥2.0 in patients aged ≥65 years as significant liver fibrosis. Results: The numbers of patients with a low, intermediate, and high probability of advanced fibrosis based on the fibrosis‐4 index were 3360 (81.7%), 668 (16.2%), and 84 (2.0%). There were 3828 (93.1%) and 284 (6.9%) patients diagnosed with MASLD and non‐MASLD. The non‐MASLD group, compared with the MASLD group, was significantly younger (44 vs. 55 years) and had a higher percentage of women (62.3% vs. 27.7%). Significant fibrosis, defined based on the fibrosis‐4 index, was present in 18.5% of the MASLD group and 15.5% of the non‐MASLD group. In a multivariable analysis, female sex (OR 6.170, 95% CI 3.180–12.000; p < 0.001) was independently associated with non‐MASLD in patients with a significant fibrosis. Among non‐MASLD patients with a significant fibrosis (n = 44), body mass index was significantly lower in females than in males (p < 0.001). In a multivariable analysis of patients aged <65 years, female sex (OR, 7.700; 95% CI, 3.750–15.800; p < 0.001) remained independently associated with non‐MASLD in patients with a significant fibrosis. Conclusions: MASLD may inappropriately exclude patients with significant fibrosis, especially lean females with nonalcoholic fatty liver disease. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Four cases of non‐Helicobacter pylori Helicobacter‐infected gastritis with duodenal spiral bacilli.

Author

Agawa, Hiroyuki, Tsukadaira, Toshihisa, Kobayashi, Natsuko, Kodaira, Himiko, Ota, Hiroyoshi, Matsumoto, Takehisa, Horiuchi, Kazuki, Negishi, Tatsuya, and Tada, Toshifumi

Subjects
DUODENAL tumors, HELICOBACTER pylori infections, GASTRITIS, HELICOBACTER pylori, GASTRIC mucosa, GASTRIC juice, POLYMERASE chain reaction
Abstract

Background: Non‐Helicobacter pylori Helicobacter (NHPH) is rarely detected in duodenal mucosa due to its preference for slightly acidic environments. Here, we report four cases of NHPH‐infected gastritis with duodenal spiral bacilli, potentially NHPH, indicating the possibility of duodenal mucosal infection. Case Presentation: In every case, gastric mucosa showed endoscopic findings characteristic of NHPH‐infected gastritis, and a mucosal biopsy was taken from the duodenal bulb; spiral bacilli were identified under microscopy using Giemsa staining. Case 1, a 46‐year‐old man, had diffuse spotty redness, mucosal edema, and multiple tiny erosions in the duodenal bulb, along with larger erosions in the second portion of the duodenum upon endoscopic examination. Histopathologically, moderate infiltration of mononuclear cells and neutrophils in the lamina propria and gastric epithelial metaplasia were observed. Case 2, a 54‐year‐old man, showed an elevated lesion, 1 cm in diameter, with multiple red spots and a few tiny erosions in the duodenal bulb. Histopathologically, mild inflammatory cell infiltration and gastric epithelial metaplasia were observed. In Case 3, a 52‐year‐old man, endoscopy revealed a flat elevated lesion, 7 mm in diameter, with multiple red spots and a few tiny erosions in the anterior wall of the duodenal bulb. Histopathologically, we observed moderate inflammatory cell infiltration in the gastric antrum and gastric epithelial metaplasia in the duodenal bulb. Case 4, a 40‐year‐old man, showed mild spotty redness in the duodenal bulb. Histopathologically, mild mononucleocyte infiltration and gastric epithelial metaplasia were observed. A single spiral bacillus was observed in Case 4 by microscopy. In all but Case 2, Helicobacter suis was identified in the gastric juice by polymerase chain reaction analysis. Conclusions: Spiral bacilli resembling NHPH may infect the duodenal mucosa, particularly the bulb, causing inflammation. Gastric contents entering the duodenum may reduce the intraduodenal pH, promoting NHPH survival and proliferation. [ABSTRACT FROM AUTHOR]

Published
2024
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39. MASLD may inappropriately exclude lean female NAFLD patients with significant liver fibrosis.

Author

Kobayashi, Natsuko, primary, Tada, Toshifumi, additional, Nishimura, Takashi, additional, Matono, Tomomitsu, additional, Yuri, Yukihisa, additional, Takashima, Tomoyuki, additional, Aizawa, Nobuhiro, additional, Ikeda, Naoto, additional, Fukunishi, Shinya, additional, Hashimoto, Mariko, additional, Ohyanagi, Mitsumasa, additional, Enomoto, Hirayuki, additional, and Iijima, Hiroko, additional

Published
2023
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41. Triple-drug combination therapy versus six-month proton pump inhibitor monotherapy in non-Helicobacter pylori Helicobacter eradication: a clinical study.

Author

TSUKADAIRA, Toshihisa, primary, HAYASHI, Seiichi, additional, OTA, Hiroyoshi, additional, KOBAYASHI, Natsuko, additional, AGAWA, Hiroyuki, additional, KODAIRA, Himiko, additional, SEKIGUCHI, Yasuhiro, additional, MATSUMOTO, Takehisa, additional, HORIUCHI, Kazuki, additional, NEGISHI, Tatsuya, additional, and TADA, Toshifumi, additional

Published
2023
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45. Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability

Author

Li, Xue, primary, Ono, Chiaki, additional, Warita, Noriko, additional, Shoji, Tomoka, additional, Nakagawa, Takashi, additional, Usukura, Hitomi, additional, Yu, Zhiqian, additional, Takahashi, Yuta, additional, Ichiji, Kei, additional, Sugita, Norihiro, additional, Kobayashi, Natsuko, additional, Kikuchi, Saya, additional, Kimura, Ryoko, additional, Hamaie, Yumiko, additional, Hino, Mizuki, additional, Kunii, Yasuto, additional, Murakami, Keiko, additional, Ishikuro, Mami, additional, Obara, Taku, additional, Nakamura, Tomohiro, additional, Nagami, Fuji, additional, Takai, Takako, additional, Ogishima, Soichi, additional, Sugawara, Junichi, additional, Hoshiai, Tetsuro, additional, Saito, Masatoshi, additional, Tamiya, Gen, additional, Fuse, Nobuo, additional, Fujii, Susumu, additional, Nakayama, Masaharu, additional, Kuriyama, Shinichi, additional, Yamamoto, Masayuki, additional, Yaegashi, Nobuo, additional, Homma, Noriyasu, additional, and Tomita, Hiroaki, additional

Published
2023
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49. Cadmium accumulation dynamics in the rice endosperm during grain filling revealed by autoradiography.

Author

Hirose, Atsushi, Tanoi, Keitaro, Nakanishi, Tomoko M., and Kobayashi, Natsuko I.

Subjects
ENDOSPERM, BROWN rice, AUTORADIOGRAPHY, RICE, POLLUTANTS, CADMIUM, GRAIN, RICE straw
Abstract

Cadmium (Cd) is one of the environmental pollutants contaminated in our food. Several previous reports showed that rice polishing cannot be efficient to reduce Cd content in white rice, implying the characteristic Cd distribution in rice grain. However, Cd distribution has not been fully elucidated so far. Herein, 109Cd radiotracer experiment was performed using the rice seedlings at various time points after flowering to obtain autoradiographs of the brown rice to visually understand the Cd transport and distribution during the grain‐filling process. It was shown that 109Cd accumulated in the outermost area of the brown rice, and also in the middle part of the starchy endosperm, resulting in the appearance of the double circle distribution pattern, which was not observed in the autoradiographs of 65Zn. The inner circle of 109Cd located around the center of the endosperm was developed particularly at around 8 and 10 days after flowering. After this period, 109Cd started to deposit at the outer part of the endosperm, which was also found in the autoradiograph of 14C‐sucrose. Considering the physiology of grain development, the contribution of water transport and protein synthesis in the endosperm on the characteristic Cd distribution pattern was hypothesized. [ABSTRACT FROM AUTHOR]

Published
2024
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